BS60759

antibody from Bioworld Technology, Inc
Targeting: PPP1R13B ASPP1, KIAA0771, p53BP2-like, p85
Provider product page for BS60759

Antibody data

Product number
BS60759 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PPP1R13B polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human PPP1R13B
Description
ASPP proteins interact with p53 and are responsible for enhancing p53-induced apoptosis but not cell cycle arrest. Inhibition of endogenous ASPP1 (PPP1R13B) function inhibits the apoptotic function of endogenous p53 in response to apoptotic stimuli. ASPP1 amplifies DNA binding and transactivation function of p53 on the promoters of proapoptotic genes in vivo. Expres-sion of ASPP1 is often downregulated in human breast carcinomas expressing wildtype p53, but not in those expressing mutant p53. This research indicates that ASPP1 regulates the tumor suppression function of p53 in vivo. ASPP1 is predominantly a cytoplasmic protein, although some fraction of the polypeptide is nuclear. Defects in PPP1R13B, the gene which encodes ASPP1, may be a cause of breast cancers. The deduced ASPP1 protein contains 1,090 amino acid residues.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PPP1R13B protein structure - BS60759 shown in red.