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- Antigen structure
- References [17]
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- Product number
- 19888-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19888-1-AP, RRID:AB_10639363
- Product name
- NPC2 antibody
- Antibody type
- Polyclonal
- Description
- NPC2 antibody (Cat. #19888-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A pH-driven receptor switch from ACE2 to NPC1 enables endosomal entry of SARS-CoV-2.
NPC2 suppresses osteolytic metastasis in lung adenocarcinoma via the AKT/mTOR pathway and tumor-osteoclast crosstalk.
Reprogramming of cholesterol sensing in epithelial cells supports pancreatic inflammation.
Integrative Machine Learning Analysis of Programmed Cell Death Pathways Identifies Novel Diagnostic Biomarkers for Atrial Fibrillation.
GDF15 promotes the resistance of epithelial ovarian cancer cells to gemcitabine via DHCR24-mediated cholesterol metabolism to elevate ABCB1 and ABCC1 levels in lipid rafts.
A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction.
COL6A1, LAPTM5, and ZFAND2A as Crucial Biomolecules Driving Immunoregulation in Human Nucleus Pulposus Degeneration.
ALKBH5-mediated NPC2 mRNA m(6)A demethylation promotes resistance to oxaliplatin in colorectal cancer.
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
The Aging Lacrimal Gland of Female C57BL/6J Mice Exhibits Multinucleate Macrophage Infiltration Associated With Lipid Dysregulation.
The ORP9-ORP11 dimer promotes sphingomyelin synthesis.
Large-Scale CRISPR Screen of LDLR Pathogenic Variants.
Multi-Cell Line Analysis of Lysosomal Proteomes Reveals Unique Features and Novel Lysosomal Proteins.
Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells.
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses.
Zheng YH, Liu Z, Pang Y, Khan I, Ou L, Hu Y, Li S, Richner J, Zhou T
Research square 2026 Mar 4;
Research square 2026 Mar 4;
NPC2 suppresses osteolytic metastasis in lung adenocarcinoma via the AKT/mTOR pathway and tumor-osteoclast crosstalk.
Zhou S, Li N, Li R, Ding Y, Zhu Y, Pan Y, Liu Y, Zhang Y, Yang H, Wang Q
iScience 2026 Mar 20;29(3):115017
iScience 2026 Mar 20;29(3):115017
Reprogramming of cholesterol sensing in epithelial cells supports pancreatic inflammation.
Milan G, Mareninova OA, Fantuz M, Spacci M, Paoli C, Pineda JA, Noè R, Calciolari B, Zoncu R, Gukovskaya AS, Carrer A
Molecular metabolism 2026 Jan;103:102292
Molecular metabolism 2026 Jan;103:102292
Integrative Machine Learning Analysis of Programmed Cell Death Pathways Identifies Novel Diagnostic Biomarkers for Atrial Fibrillation.
Peng H, Xia Z, Zhao Y, Xie D
Journal of inflammation research 2025;18:18247-18266
Journal of inflammation research 2025;18:18247-18266
GDF15 promotes the resistance of epithelial ovarian cancer cells to gemcitabine via DHCR24-mediated cholesterol metabolism to elevate ABCB1 and ABCC1 levels in lipid rafts.
Guo L, He Y, Xin H
American journal of cancer research 2025;15(2):452-469
American journal of cancer research 2025;15(2):452-469
A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction.
Davis OB, Kung JE, Davis SS, Ghosh R, Andrews SV, Gould NS, Kluss JH, Thomsen E, Agam M, Coan JP, Maloney MT, Nguyen AH, Nguyen HN, Propson NE, Lozano EI, Yuan T, Xa K, Sperberg RAP, Jain S, Lawrence R, Ullman JC, Balasundar S, Benton HP, Petkovic M, Qerqez AN, Wang X, Zhu S, Di Paolo G, Kariolis MS, Mahon CS, Arguello A, Vocadlo DJ, Cookson MR, Suh JH, Rougé L, Henry AG
bioRxiv : the preprint server for biology 2025 Sep 2;
bioRxiv : the preprint server for biology 2025 Sep 2;
COL6A1, LAPTM5, and ZFAND2A as Crucial Biomolecules Driving Immunoregulation in Human Nucleus Pulposus Degeneration.
Lu ZY, Chen PB, Xu QY, Mardan M, You MJ, Li B, Jiang SD, Jiang LS, Zheng XF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71145
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71145
ALKBH5-mediated NPC2 mRNA m(6)A demethylation promotes resistance to oxaliplatin in colorectal cancer.
Wan P, Ren Y, Li HT
Functional & integrative genomics 2025 Jul 19;25(1):158
Functional & integrative genomics 2025 Jul 19;25(1):158
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
Du J, Ji X, Xu B, Du Q, Li Y, Zhou B, Liu X, Xu Z, Jiang Y, Kou B, Li Z, Cui C, Lin J
Metabolism: clinical and experimental 2024 Mar;152:155769
Metabolism: clinical and experimental 2024 Mar;152:155769
The Aging Lacrimal Gland of Female C57BL/6J Mice Exhibits Multinucleate Macrophage Infiltration Associated With Lipid Dysregulation.
Choi M, Toscano C, Edman MC, de Paiva CS, Hamm-Alvarez SF
Investigative ophthalmology & visual science 2024 Jun 3;65(6):1
Investigative ophthalmology & visual science 2024 Jun 3;65(6):1
The ORP9-ORP11 dimer promotes sphingomyelin synthesis.
Cabukusta B, Borst Pauwels S, Akkermans JJLL, Blomberg N, Mulder AA, Koning RI, Giera M, Neefjes J
eLife 2024 Aug 6;12
eLife 2024 Aug 6;12
Large-Scale CRISPR Screen of LDLR Pathogenic Variants.
Li M, Ma L, Chen Y, Li J, Wang Y, You W, Yuan H, Tang X, Ouyang H, Pang D
Research (Washington, D.C.) 2023;6:0203
Research (Washington, D.C.) 2023;6:0203
Multi-Cell Line Analysis of Lysosomal Proteomes Reveals Unique Features and Novel Lysosomal Proteins.
Akter F, Bonini S, Ponnaiyan S, Kögler-Mohrbacher B, Bleibaum F, Damme M, Renard BY, Winter D
Molecular & cellular proteomics : MCP 2023 Mar;22(3):100509
Molecular & cellular proteomics : MCP 2023 Mar;22(3):100509
Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells.
Xu D, Ma R, Ju Y, Song X, Niu B, Hong W, Wang R, Yang Q, Zhao Z, Zhang Y, Zheng Y, Bai Q, Lv M, Sun N, Li X
Nature communications 2022 Jul 30;13(1):4428
Nature communications 2022 Jul 30;13(1):4428
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Davis OB, Shin HR, Lim CY, Wu EY, Kukurugya M, Maher CF, Perera RM, Ordonez MP, Zoncu R
Developmental cell 2021 Feb 8;56(3):260-276.e7
Developmental cell 2021 Feb 8;56(3):260-276.e7
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.
Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R
Nature communications 2021 Feb 11;12(1):961
Nature communications 2021 Feb 11;12(1):961
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses.
Zhang R, Miner JJ, Gorman MJ, Rausch K, Ramage H, White JP, Zuiani A, Zhang P, Fernandez E, Zhang Q, Dowd KA, Pierson TC, Cherry S, Diamond MS
Nature 2016 Jul 7;535(7610):164-8
Nature 2016 Jul 7;535(7610):164-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NPC2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human NPC2. This antibody recognizes human, mouse, rat antigen. The NPC2 antibody has been validated for the following applications: ELISA, WB analysis.
