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- References [185]
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- Product number
- 21327-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21327-1-AP, RRID:AB_10733646
- Product name
- Cathepsin D antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Cathepsin D antibody (Cat. #21327-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integration of Single-cell and Bulk Transcriptome Analyses Unravels a Macrophage-based Gene Signature for Prognostication and Treatment in Triple-negative Breast Cancer.
Phosphatidylethanolamine Alleviates Osteoarthritis Progression by Inhibiting Oxidative Stress-Induced Chondrocyte Ferroptosis in a Lysosomal-Dependent Manner.
Schisandrin B enhances autophagy and random flaps survival through the PPARG-mediated PI3K/AKT/mTOR signaling pathway.
NPC2 suppresses osteolytic metastasis in lung adenocarcinoma via the AKT/mTOR pathway and tumor-osteoclast crosstalk.
Inhibition of PLA2G15 Alleviates Palmitic Acid-Induced Lysosomal Membrane Permeabilization in Human Nucleus Pulposus Cells During Intervertebral Disc Degeneration.
Sphinganine-induced lysosomal membrane permeabilization: Interplay with subcellular oxidative levels.
Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer.
Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis.
A novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation.
Differential roles of the type I and II secretion systems for the intracellular ABC141 Acinetobacter baumannii infection, which elicits an atypical hypoxia response in endothelial cells.
CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7-Positive Vesicle Fusion with Target Membranes.
Ubiquitination degradation of GATA4 by CUL4B promotes ovarian cancer metastasis by inducing lysosomal acidification.
FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.
Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma.
GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi.
Exploring plasticisers-osteoporosis links and mechanisms: a cohort and network toxicology study.
Autophagy cargo profiles in skeletal muscle during starvation and exercise.
Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson's disease pathogenesis.
Flufenamic acid inhibits pyroptosis in ischemic flaps via the AMPK-TRPML1-Calcineurin signaling pathway.
Bioinformatics analyses reveal the autophagy-related feature biomarkers in dilated cardiomyopathy with heart failure.
LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2.
A role for CASM in the repair of damaged Golgi architecture.
TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation.
The lysosome-associated SLAMF7 inhibits the development of ovarian cancer by promoting lysosomal damage.
UQCRC1 is a Key Pathogenic Determinant and Potential Therapeutic Target for Cognitive Impairment in Alzheimer's Disease.
SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca(2+) Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.
Evaluating Parkinson's disease biomarkers in substantia nigra following sublethal γ-radiation exposure in a large animal model.
Modular Nanoassemblies Mimicking p62 Aggregates for Targeted Organelle Sequestration and Degradation against Breast Cancer.
Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo.
Mechanisms of Intermittent Theta-Burst Stimulation Upregulates TFEB and Restores Autophagy to Play a Neuroprotective Role in the Acute Phase After Cerebral Ischemia Reperfusion.
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70-LAMP2A interaction in non-small cell lung cancer cells.
Liensinine overcomes EGFR-TKI resistance in lung adenocarcinoma through DRP1-mediated autophagy.
Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low-Temperature Photothermal Therapy via Targeting HSP90-TXNDC9 Interactions.
Recovery of Lysosomal Acidification and Autophagy Flux by Attapulgite Nanorods: Therapeutic Potential for Lysosomal Disorders.
Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2α.
Exploring Exosome Contributions to Gouty Arthritis: A Proteomics and Experimental Study.
Visualizing bulk autophagy in vivo by tagging endogenous LC3B.
Poldip2 Aggravates inflammation in diabetic retinopathy by impairing mitophagy via the AMPK/ULK1/Pink1 pathway.
Loss of FMRP in microglia promotes degeneration of parvalbumin neurons and audiogenic seizures via progranulin insufficiency.
TFE3-mediated lysosomal biogenesis and homeostasis alleviates arsenic-induced lysosomal and immune dysfunction in macrophages.
Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy.
20-Deoxyingenol Activates Mitophagy Through TFEB and Promotes Functional Recovery After Spinal Cord Injury.
Repressing cytokine storm-like response in macrophages by targeting the eIF2α-integrated stress response pathway.
Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease.
Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.
Hypoxia-induced secretory autophagy in cancer-associated fibroblasts promotes ECM remodelling through serglycin secretion in oral squamous cell carcinoma.
PI3K/mTOR Inhibitor Induces Context-Dependent Apoptosis and Methuosis in Cancer Cells.
STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy-lysosome machinery.
BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes.
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux.
MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2.
Syntaxin-2 balances phagocytic uptake and phagolysosomal clearance in macrophages.
Design, Synthesis, and Biological Evaluation of Naphthalimide-Polyamine Conjugate as a Potential Anti-Colorectal Cancer Agent.
The therapeutic potential of (R)-carvedilol in Huntington's disease through enhancement of autophagy-lysosomal pathway via GSK-3β inhibition.
Tetrandrine alleviates macrophage activation syndrome after CAR-T cell therapy.
TFEB-dependent autophagy-lysosomal pathway is required for NRF2-driven antioxidative action in obstructive sleep apnea-induced neuronal injury.
Early endolysosomal dysfunction is a contributing factor to gadolinium-based contrast agent mouse renal proximal tubule epithelial cell injury.
Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells.
RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation.
St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo.
Transforming growth factor-β1 protects mechanically injured cortical murine neurons by reducing trauma-induced autophagy and apoptosis.
Inhibition of PLA2G4A attenuated valproic acid- induced lysosomal membrane permeabilization and restored impaired autophagic flux: Implications for hepatotoxicity.
Trehalose Rescues Postmenopausal Osteoporosis Induced by Ovariectomy through Alleviating Osteoblast Pyroptosis via Promoting Autophagy.
miR-93-5p impairs autophagy-lysosomal pathway via TET3 after subarachnoid hemorrhage.
An initial HOPS-mediated fusion event is critical for autophagosome transport initiation from the axon terminal.
NEMO-Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase-Induced Lysosome Membrane Permeabilization.
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.
Study on low concentration deltamethrin toxicity mediated by phospholipase D in Chinese mitten crab (Eriocheir sinensis) ovary.
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Itaconate uptake via SLC13A3 improves hepatic antibacterial innate immunity.
Evaluation of hepatic AMPK, mTORC1, and autophagy-lysosomal pathway in cows with mild or moderate fatty liver.
Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy.
DADLE promotes motor function recovery by inhibiting cytosolic phospholipase A(2) mediated lysosomal membrane permeabilization after spinal cord injury.
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion.
Loss of the Golgi-localized v-ATPase subunit does not alter insulin granule formation or pancreatic islet β-cell function.
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions.
scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network.
Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3.
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps.
Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745(T) induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in non-small cell lung cancer cell lines.
Exploring the inhibitory impact of Mongolian medicinal He-Zi-3 soup on mammary gland hyperplasia in rats induced by estrogen and progestogen.
FGF-18 Protects the Injured Spinal cord in mice by Suppressing Pyroptosis and Promoting Autophagy via the AKT-mTOR-TRPML1 axis.
Acetylation of MOB1 mediates polyphyllin II-reduced lysosome biogenesis in breast cancer by promoting the cytoplasmic retention of the YAP/TFEB coactivator complex.
Coxiella burnetii effector CvpE maintains biogenesis of Coxiella-containing vacuoles by suppressing lysosome tubulation through binding PI(3)P and perturbing PIKfyve activity on lysosomes.
Molecular Insights into the Regulation of GNPTAB by TMEM251.
PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease.
A snake cathelicidin enhances transcription factor EB-mediated autophagy and alleviates ROS-induced pyroptosis after ischaemia-reperfusion injury of island skin flaps.
Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury.
Common Markers and Small Molecule Inhibitors in Golgi Studies.
Immunofluorescence Microscopy of the Mammalian Golgi Apparatus.
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.
Astrocytic AT1R deficiency ameliorates Aβ-induced cognitive deficits and synaptotoxicity through β-arrestin2 signaling.
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
Rosuvastatin promotes survival of random skin flaps through AMPK-mTOR pathway-induced autophagy.
Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health.
Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect.
A novel selective estrogen receptor degrader induces cell cycle arrest in breast cancer via ERα degradation and the autophagy-lysosome pathway.
Exercise pretreatment alleviates neuroinflammation and oxidative stress by TFEB-mediated autophagic flux in mice with ischemic stroke.
Nuciferine improves random skin flap survival via TFEB-mediated activation of autophagy-lysosomal pathway.
Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization.
Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement.
Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons.
Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells.
HD-sEVs in bovine follicular fluid regulate granulosa cell apoptosis and estradiol secretion through the autophagy pathway.
Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury.
Narirutin activates TFEB (transcription factor EB) to protect against Acetaminophen-induced liver injury by targeting PPP3/calcineurin.
Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma.
Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain.
Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy.
Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.
Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo.
Moderate Treadmill Exercise Alleviates NAFLD by Regulating the Biogenesis and Autophagy of Lipid Droplet.
Paeonol protects renal tubular cells against cadmium-induced cytotoxicity via alleviating oxidative stress, inhibiting inflammatory responses and restoring autophagy.
Wolframin is a novel regulator of tau pathology and neurodegeneration.
Overactivation of hepatic mechanistic target of rapamycin kinase complex 1 (mTORC1) is associated with low transcriptional activity of transcription factor EB and lysosomal dysfunction in dairy cows with clinical ketosis.
Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.
GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke.
Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway.
EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer.
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress.
mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species.
Activated autophagy-lysosomal pathway in dairy cows with hyperketonemia is associated with lipolysis of adipose tissues.
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses.
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca(2+)-PPP3/calcineurin-TFEB axis.
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.
Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media.
Curcumin promotes the survival of ischemic random skin flaps via autophagy.
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Prenatal-onset of congenital neuronal ceroid lipofuscinosis with a novel CTSD mutation.
Exopolysaccharides from Bifidobacterium animalis Ameliorate Escherichia coli-Induced IPEC-J2 Cell Damage via Inhibiting Apoptosis and Restoring Autophagy.
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models.
Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD.
Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.
DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.
TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7.
Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.
Detrimental Effect of Sitagliptin Induced Autophagy on Multiterritory Perforator Flap Survival.
Staphylococcus aureus Avoids Autophagy Clearance of Bovine Mammary Epithelial Cells by Impairing Lysosomal Function.
Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.
Notoginsenoside R1 Protects Against the Acrylamide-Induced Neurotoxicity via Upregulating Trx-1-Mediated ITGAV Expression: Involvement of Autophagy.
Baicalein Attenuates Pyroptosis and Endoplasmic Reticulum Stress Following Spinal Cord Ischemia-Reperfusion Injury via Autophagy Enhancement.
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.
Autophagic blockage by bismuth sulfide nanoparticles inhibits migration and invasion of HepG2 cells.
Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens.
An Experimental Model of Neurodegenerative Disease Based on Porcine Hemagglutinating Encephalomyelitis Virus-Related Lysosomal Abnormalities.
Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis.
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting.
Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.
27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells.
Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.
Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk.
ERβ promotes Aβ degradation via the modulation of autophagy.
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy.
Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux.
TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.
Epigallocatechin-3-gallate inhibits H(2)O(2)-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor.
Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species.
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
Citreoviridin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis in Human Liver HepG2 Cells.
Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells.
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.
Proteomic features of potential tumor suppressor NESG1 in nasopharyngeal carcinoma.
Huang Y, Yu Y, Zhu Y, Lu Q, Zhang Z, Wang X, Wang X, Zheng Y
International journal of medical sciences 2026;23(1):253-270
International journal of medical sciences 2026;23(1):253-270
Phosphatidylethanolamine Alleviates Osteoarthritis Progression by Inhibiting Oxidative Stress-Induced Chondrocyte Ferroptosis in a Lysosomal-Dependent Manner.
Zheng H, Zhu Z, Zhu J, Chen D, Ruan R, Ning R
International journal of general medicine 2026;19:581128
International journal of general medicine 2026;19:581128
Schisandrin B enhances autophagy and random flaps survival through the PPARG-mediated PI3K/AKT/mTOR signaling pathway.
Li Y, Zhang J, Yang J, Gao J, Jin Y, Zhang Y, Chen H, Cai L
Free radical biology & medicine 2026 May;248:92-108
Free radical biology & medicine 2026 May;248:92-108
NPC2 suppresses osteolytic metastasis in lung adenocarcinoma via the AKT/mTOR pathway and tumor-osteoclast crosstalk.
Zhou S, Li N, Li R, Ding Y, Zhu Y, Pan Y, Liu Y, Zhang Y, Yang H, Wang Q
iScience 2026 Mar 20;29(3):115017
iScience 2026 Mar 20;29(3):115017
Inhibition of PLA2G15 Alleviates Palmitic Acid-Induced Lysosomal Membrane Permeabilization in Human Nucleus Pulposus Cells During Intervertebral Disc Degeneration.
Duan L, Jiang J, Tu S, Li C, Dong Y, Li Y, Zhang W, Chen X
JOR spine 2026 Jun;9(2):e70178
JOR spine 2026 Jun;9(2):e70178
Sphinganine-induced lysosomal membrane permeabilization: Interplay with subcellular oxidative levels.
Cheng G, Qi C, Xu H, Wang X, Li M, Chen H, Zheng P, Liu Y, Liu J, Zhao X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Jan;1871(1):159705
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Jan;1871(1):159705
Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer.
Zhan W, Fu Y, Liu Y, Cai R, Bai F, Guo C, Cheng Y, Wu Z, Qin G, Xie Y, Zhang J, Deng Y
Cell reports. Medicine 2026 Jan 20;7(1):102534
Cell reports. Medicine 2026 Jan 20;7(1):102534
Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis.
Lane AR, Gonzalez N, Gokhale A, Zlatic SA, Allen BM, Scher NE, Roberts AM, Duong DM, Roberts BR, Vrailas-Mortimer AD, Werner E, Faundez V
bioRxiv : the preprint server for biology 2026 Jan 14;
bioRxiv : the preprint server for biology 2026 Jan 14;
A novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation.
Wang S, Han W, Zhao B, Hong Y, Li J, Miao J, Lin Z
PLoS pathogens 2026 Feb;22(2):e1013932
PLoS pathogens 2026 Feb;22(2):e1013932
Differential roles of the type I and II secretion systems for the intracellular ABC141 Acinetobacter baumannii infection, which elicits an atypical hypoxia response in endothelial cells.
Debruyne C, Hodge L, Hokamp K, Ershova AS, Kröger C, Salcedo SP
PLoS pathogens 2026 Feb;22(2):e1013265
PLoS pathogens 2026 Feb;22(2):e1013265
CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7-Positive Vesicle Fusion with Target Membranes.
Tian Y, Li J, Kang J, Xu X, Wang B, Lou S, Li J, Yang Y, Zhang Y, Zheng Y, Weng J, Liang Y, Ma W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e04665
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e04665
Ubiquitination degradation of GATA4 by CUL4B promotes ovarian cancer metastasis by inducing lysosomal acidification.
Yin X, Gao R, Geng Y, Mu X, Zhang Y, Ma Y, Chen X, Han F, Chen Z, Li F, He J
Genome biology 2026 Feb 9;27(1)
Genome biology 2026 Feb 9;27(1)
FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.
Lu W, Jiang M, Zhuang J, Song J, Zhou C, Zhou Y, Zhu Z, Wu A, Sheng S, Zhu S, Wang Z
Journal of neuroinflammation 2026 Feb 23;23(1)
Journal of neuroinflammation 2026 Feb 23;23(1)
Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma.
Han M, Guan Q, Yan F, Wang M, Xi D, Ning Q
Cell communication and signaling : CCS 2026 Feb 2;24(1)
Cell communication and signaling : CCS 2026 Feb 2;24(1)
GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi.
Nüchel J, Omidi M, Fernandes SA, Tauber M, Pohl S, Plomann M, Demetriades C
EMBO reports 2026 Apr 16;
EMBO reports 2026 Apr 16;
Exploring plasticisers-osteoporosis links and mechanisms: a cohort and network toxicology study.
Yang X, Wang X, Bao S, Li Z, Xing S, Du Z
Frontiers in toxicology 2025;7:1617663
Frontiers in toxicology 2025;7:1617663
Autophagy cargo profiles in skeletal muscle during starvation and exercise.
Farhan M, Lyu S, Nguyen TP, Zhang D, Liang H, Zhou Y, An YA, Wang J, Yang H, Du G, Liu Y
Autophagy reports 2025;4(1):2593060
Autophagy reports 2025;4(1):2593060
Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson's disease pathogenesis.
Cheng C, Yang H, Tian L, Ni Y, Jia C, Le W, Wang Q
Frontiers in aging neuroscience 2025;17:1612389
Frontiers in aging neuroscience 2025;17:1612389
Flufenamic acid inhibits pyroptosis in ischemic flaps via the AMPK-TRPML1-Calcineurin signaling pathway.
Chen L, Yang N, Chen K, Huang Y, Liu X, Yu G, Wang F, Gou Y, Wang Y, Lu X, Wang Y, Zhu L, Gao W, Ding J
Burns & trauma 2025;13:tkaf007
Burns & trauma 2025;13:tkaf007
Bioinformatics analyses reveal the autophagy-related feature biomarkers in dilated cardiomyopathy with heart failure.
Ren J, Li Z, Wang Y, Wang Y, Li J
Frontiers in cardiovascular medicine 2025;12:1692768
Frontiers in cardiovascular medicine 2025;12:1692768
LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2.
Shao R, Liu W, Feng Y, Guo X, Ren Z, Hou X, He B
Autophagy 2025 Sep;21(9):1888-1910
Autophagy 2025 Sep;21(9):1888-1910
A role for CASM in the repair of damaged Golgi architecture.
Oh S, Ullah S, Saha B, Mandell MA
bioRxiv : the preprint server for biology 2025 Sep 4;
bioRxiv : the preprint server for biology 2025 Sep 4;
TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation.
Ren W, Jiang H, Song Q, Chen Y, Tang C, Wang F, Zhu J, Ren J, Zhao Y, He Y, Cai J, Zhang T, Wang Z, Zhu C, Xue W, Peng A, Feng X, Liu Y, Yu J, Liu ZG, Cai Z
Cell reports 2025 Sep 23;44(9):116186
Cell reports 2025 Sep 23;44(9):116186
The lysosome-associated SLAMF7 inhibits the development of ovarian cancer by promoting lysosomal damage.
Zou W, Fang X, Qian Z, Nie L
Molecular and cellular endocrinology 2025 Sep 1;606:112586
Molecular and cellular endocrinology 2025 Sep 1;606:112586
UQCRC1 is a Key Pathogenic Determinant and Potential Therapeutic Target for Cognitive Impairment in Alzheimer's Disease.
Zhang J, Wu Z, Long Z, Feng C, Bai F, Li H
Molecular neurobiology 2025 Oct;62(10):13786-13806
Molecular neurobiology 2025 Oct;62(10):13786-13806
SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.
Yaxian L, Xiaodong W, Futao M, Huizhen W, Chuansheng W, Mengdi M, Bo Y, Yida L, Xin X, Ziqing F, Mingdian L, Yuxian S, Yongxiang L
International journal of biological macromolecules 2025 Oct;327(Pt 1):147188
International journal of biological macromolecules 2025 Oct;327(Pt 1):147188
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca(2+) Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.
Zhu MY, Guo YJ, Zhu YQ, Wang HZ, Wang HD, Chen HY, Jiang YX, Li H, Hui H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e15313
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e15313
Evaluating Parkinson's disease biomarkers in substantia nigra following sublethal γ-radiation exposure in a large animal model.
Murphy EK, Perl DP, Day RM, Iacono D
NPJ Parkinson's disease 2025 Oct 3;11(1):286
NPJ Parkinson's disease 2025 Oct 3;11(1):286
Modular Nanoassemblies Mimicking p62 Aggregates for Targeted Organelle Sequestration and Degradation against Breast Cancer.
Li Y, Zhang Y, Wang J, Che Y, Gong T, Zhang Z, Liu R, Fu Y
ACS nano 2025 Oct 21;19(41):36478-36495
ACS nano 2025 Oct 21;19(41):36478-36495
Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo.
Shao W, Albagli EA, Jansen-West K, Daughrity LM, Tong J, Hysi A, Jiang P, Todd TW, Lee E, Alepuz DZ, Carlomagno Y, Yue M, Dunmore JA, Castanedes-Casey M, Otero PC, Kurti A, Prudencio M, Cook CN, Dickson DW, Gendron TF, Petrucelli L, Zhang YJ
iScience 2025 Oct 17;28(10):113460
iScience 2025 Oct 17;28(10):113460
Mechanisms of Intermittent Theta-Burst Stimulation Upregulates TFEB and Restores Autophagy to Play a Neuroprotective Role in the Acute Phase After Cerebral Ischemia Reperfusion.
Zhang XY, Zhao YN, Gui LH, Han PP, Huang YY, Bi X
Neurochemical research 2025 Nov 27;51(1):4
Neurochemical research 2025 Nov 27;51(1):4
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Zhu Y, Yang S, Su S, Huang Y, Chen Y, Liang H, Miao J, Wu Z, Li X, Xiao J, Wang X
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70-LAMP2A interaction in non-small cell lung cancer cells.
Dong RF, Qin CJ, Yin Y, Han LL, Xiao CM, Wang KD, Wei RY, Xia YZ, Kong LY
British journal of pharmacology 2025 May;182(10):2287-2309
British journal of pharmacology 2025 May;182(10):2287-2309
Liensinine overcomes EGFR-TKI resistance in lung adenocarcinoma through DRP1-mediated autophagy.
Chen Y, Shu C, Yan Z, Zhang S, Zhang W, Zhao J, Wang A, Li J, Zeng Y, Zhu J, Huang JA, Liu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156593
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156593
Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low-Temperature Photothermal Therapy via Targeting HSP90-TXNDC9 Interactions.
He D, Chen S, Wang X, Wen X, Gong C, Liu L, He G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2412953
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2412953
Recovery of Lysosomal Acidification and Autophagy Flux by Attapulgite Nanorods: Therapeutic Potential for Lysosomal Disorders.
Hao Y, Fan X, Huang X, Li Z, Jing Z, Zhang G, Xu Y, Zhang N, Wei P
Biomolecules 2025 May 16;15(5)
Biomolecules 2025 May 16;15(5)
Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2α.
Li Q, Zeng K, Chen Q, Han C, Wang X, Li B, Miao J, Zheng B, Liu J, Yuan X, Liu B
Autophagy 2025 Mar;21(3):619-638
Autophagy 2025 Mar;21(3):619-638
Exploring Exosome Contributions to Gouty Arthritis: A Proteomics and Experimental Study.
Lu C, Yang X, Wang X, Wang Y, Zhang B, Lin Z
International journal of molecular sciences 2025 Jun 1;26(11)
International journal of molecular sciences 2025 Jun 1;26(11)
Visualizing bulk autophagy in vivo by tagging endogenous LC3B.
Gao X, Xiong Y, Ma H, Zhou H, Liu W, Sun Q
Autophagy 2025 Jul;21(7):1591-1607
Autophagy 2025 Jul;21(7):1591-1607
Poldip2 Aggravates inflammation in diabetic retinopathy by impairing mitophagy via the AMPK/ULK1/Pink1 pathway.
Lin S, Ji Z, Gao J, Fan J, Hou J, Liu S, Wang C, Chen K, Tao L, Jiang Z
Life sciences 2025 Jul 15;373:123681
Life sciences 2025 Jul 15;373:123681
Loss of FMRP in microglia promotes degeneration of parvalbumin neurons and audiogenic seizures via progranulin insufficiency.
Li H, Choi JJ, Huang EJ, Xu B
bioRxiv : the preprint server for biology 2025 Jul 12;
bioRxiv : the preprint server for biology 2025 Jul 12;
TFE3-mediated lysosomal biogenesis and homeostasis alleviates arsenic-induced lysosomal and immune dysfunction in macrophages.
Xu G, Chen H, Cong Z, Zhou L, Zhao N, Yang Y, Li T, Liu X, Wang Y, Li B
Ecotoxicology and environmental safety 2025 Jul 1;299:118374
Ecotoxicology and environmental safety 2025 Jul 1;299:118374
Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy.
Si M, Fu J, Fang M, Lu Y, Huang J, Li H, Wang P, Liao M, Zhu J, Li P, Zhong W, Guo Z, Yang W, Ye Z, Hu H, Yu X
Nature communications 2025 Jul 1;16(1):5536
Nature communications 2025 Jul 1;16(1):5536
20-Deoxyingenol Activates Mitophagy Through TFEB and Promotes Functional Recovery After Spinal Cord Injury.
Wu C, Chen Y, Chen X, Zhang Y, Zhao X, Deng Y, Li C, Zhang D, Zhang X, Wang S
Molecular neurobiology 2025 Jan;62(1):445-460
Molecular neurobiology 2025 Jan;62(1):445-460
Repressing cytokine storm-like response in macrophages by targeting the eIF2α-integrated stress response pathway.
Wang X, Dai C, Cheng W, Wang J, Cui X, Pan G, Chen Y, Han Y, Guo X, Jiang F
International immunopharmacology 2025 Feb 6;147:113965
International immunopharmacology 2025 Feb 6;147:113965
Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease.
Dan X, Croteau DL, Liu W, Chu X, Robbins PD, Bohr VA
bioRxiv : the preprint server for biology 2025 Feb 20;
bioRxiv : the preprint server for biology 2025 Feb 20;
Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.
Chen H, Zhu M, Zhao Z, Jiang Y, Wang H, Liu Y, Chen Y, Li H, Xun C, Hui H
Pharmacological research 2025 Dec;222:108050
Pharmacological research 2025 Dec;222:108050
Hypoxia-induced secretory autophagy in cancer-associated fibroblasts promotes ECM remodelling through serglycin secretion in oral squamous cell carcinoma.
Zhang Y, Tao C, Yin X, Wang Z, Zhang Y, Yu J, Wang Y, Han W
Clinical and translational medicine 2025 Dec;15(12):e70556
Clinical and translational medicine 2025 Dec;15(12):e70556
PI3K/mTOR Inhibitor Induces Context-Dependent Apoptosis and Methuosis in Cancer Cells.
Hua X, Chen P, Zeng W, Han Y, Guo Y, Chen Y, Li C, Du Y, Ma M, Dong S
Pharmaceuticals (Basel, Switzerland) 2025 Dec 4;18(12)
Pharmaceuticals (Basel, Switzerland) 2025 Dec 4;18(12)
STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy-lysosome machinery.
Shen QH, Xia JY, Ma Y, Xu SS
European journal of medical research 2025 Dec 30;31(1):173
European journal of medical research 2025 Dec 30;31(1):173
BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes.
Rodwell-Bullock J, Blau E, Ganguly A, Deaton C, Johnson GVW
bioRxiv : the preprint server for biology 2025 Dec 17;
bioRxiv : the preprint server for biology 2025 Dec 17;
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux.
Wu F, Li C, Song X, Xie L
Cellular signalling 2025 Aug;132:111834
Cellular signalling 2025 Aug;132:111834
MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2.
Gao X, Jia S, Gao L, Chen S, Zhang Y, Liang X, Zhang L, Zhang B, Meng C
Free radical biology & medicine 2025 Aug 1;235:213-230
Free radical biology & medicine 2025 Aug 1;235:213-230
Syntaxin-2 balances phagocytic uptake and phagolysosomal clearance in macrophages.
Samanta S, Nandi A, Datta R, Dolai S
Journal of cell science 2025 Aug 1;138(15)
Journal of cell science 2025 Aug 1;138(15)
Design, Synthesis, and Biological Evaluation of Naphthalimide-Polyamine Conjugate as a Potential Anti-Colorectal Cancer Agent.
Dai F, Cao Y, Zhu C, Li Y, Ma X, Wang S, Liu H, Xie X, Gao L, Wang Y, Wang C
Chemistry & biodiversity 2025 Apr;22(4):e202401873
Chemistry & biodiversity 2025 Apr;22(4):e202401873
The therapeutic potential of (R)-carvedilol in Huntington's disease through enhancement of autophagy-lysosomal pathway via GSK-3β inhibition.
Cheng CY, Chen KP, Tseng TS, Hua KF, Ju TC
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2025 Apr;22(3):e00557
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2025 Apr;22(3):e00557
Tetrandrine alleviates macrophage activation syndrome after CAR-T cell therapy.
Wang Y, Ding L, Wang Y, Li H, Wu M, Li S, Xu Q, Chen Y, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156483
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156483
TFEB-dependent autophagy-lysosomal pathway is required for NRF2-driven antioxidative action in obstructive sleep apnea-induced neuronal injury.
Song J, Wang T, Hong JS, Wang Y, Feng J
Cellular signalling 2025 Apr;128:111630
Cellular signalling 2025 Apr;128:111630
Early endolysosomal dysfunction is a contributing factor to gadolinium-based contrast agent mouse renal proximal tubule epithelial cell injury.
DeAguero J, Howard T, Escobar GP, Dokladny K, Wagner B
Cell biology and toxicology 2025 Apr 3;41(1):65
Cell biology and toxicology 2025 Apr 3;41(1):65
Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells.
He X, Tian S, Bu L, Zhao X, Zheng L, Zhang P, Guo R, Ma M
Scientific reports 2025 Apr 3;15(1):11502
Scientific reports 2025 Apr 3;15(1):11502
RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation.
Rosell A, Krygowska AA, Alcón Pérez M, Cuesta C, Voisin MB, de Paz J, Sanz-Fraile H, Rajeeve V, Carreras-González A, Berral-González A, Swinyard O, Gabandé-Rodríguez E, Downward J, Alcaraz J, Anguita J, García-Macías C, De Las Rivas J, Cutillas PR, Castellano Sanchez E
eLife 2025 Apr 24;13
eLife 2025 Apr 24;13
St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo.
Guo Y, Wang S, Liu Q, Dong Y, Liu Y
PloS one 2024;19(12):e0316268
PloS one 2024;19(12):e0316268
Transforming growth factor-β1 protects mechanically injured cortical murine neurons by reducing trauma-induced autophagy and apoptosis.
Li Y, Deng H, Zhang H, Yang L, Wang S, Wang H, Zhu J, Li X, Chen X, Lin Y, Li R, Wang G, Li K
Frontiers in cellular neuroscience 2024;18:1381279
Frontiers in cellular neuroscience 2024;18:1381279
Inhibition of PLA2G4A attenuated valproic acid- induced lysosomal membrane permeabilization and restored impaired autophagic flux: Implications for hepatotoxicity.
Wang ML, Zhang YJ, He DL, Li T, Zhao MM, Zhao LM
Biochemical pharmacology 2024 Sep;227:116438
Biochemical pharmacology 2024 Sep;227:116438
Trehalose Rescues Postmenopausal Osteoporosis Induced by Ovariectomy through Alleviating Osteoblast Pyroptosis via Promoting Autophagy.
Hu X, Wang W, Chen X, Kong C, Zhao X, Wang Z, Zhang H, Lu S
Biomedicines 2024 Sep 29;12(10)
Biomedicines 2024 Sep 29;12(10)
miR-93-5p impairs autophagy-lysosomal pathway via TET3 after subarachnoid hemorrhage.
Ding PF, Liu XZ, Peng Z, Cui Y, Liu Y, Zhang JT, Zhu Q, Wang J, Zhou Y, Gao YY, Hang CH, Li W
Experimental neurology 2024 Oct;380:114904
Experimental neurology 2024 Oct;380:114904
An initial HOPS-mediated fusion event is critical for autophagosome transport initiation from the axon terminal.
Wisner SR, Chlebowski M, Mandal A, Mai D, Stein C, Petralia RS, Wang YX, Drerup CM
Autophagy 2024 Oct;20(10):2275-2296
Autophagy 2024 Oct;20(10):2275-2296
NEMO-Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase-Induced Lysosome Membrane Permeabilization.
Geng Y, Lou J, Wu J, Tao Z, Yang N, Kuang J, Wu Y, Zhang J, Xiang L, Shi J, Cai Y, Wang X, Chen J, Xiao J, Zhou K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2405759
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2405759
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.
Sweeney N, Kim TY, Morrison CT, Li L, Acosta D, Liang J, Datla NV, Fitzgerald JA, Huang H, Liu X, Tan GH, Wu M, Karelina K, Bray CE, Weil ZM, Scharre DW, Serrano GE, Saito T, Saido TC, Beach TG, Kokiko-Cochran ON, Godbout JP, Johnson GVW, Fu H
Acta neuropathologica 2024 Oct 11;148(1):52
Acta neuropathologica 2024 Oct 11;148(1):52
Study on low concentration deltamethrin toxicity mediated by phospholipase D in Chinese mitten crab (Eriocheir sinensis) ovary.
Sun Q, Dong J, Su Z, Huang X, Gao X, Hu K, Gong X
Aquatic toxicology (Amsterdam, Netherlands) 2024 Nov;276:107090
Aquatic toxicology (Amsterdam, Netherlands) 2024 Nov;276:107090
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Wang Y, Yang Y, Cai Y, Aobulikasimu A, Wang Y, Hu C, Miao Z, Shao Y, Zhao M, Hu Y, Xu C, Chen X, Li Z, Chen J, Wang L, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Itaconate uptake via SLC13A3 improves hepatic antibacterial innate immunity.
Chen C, Liu C, Sun P, Zhang Z, Wang Z, Liu P, Li X
Developmental cell 2024 Nov 4;59(21):2807-2817.e8
Developmental cell 2024 Nov 4;59(21):2807-2817.e8
Evaluation of hepatic AMPK, mTORC1, and autophagy-lysosomal pathway in cows with mild or moderate fatty liver.
Du X, Chen M, Fang Z, Shao Q, Yu H, Hao X, Gao X, Ju L, Li C, Yang Y, Song Y, Lei L, Liu G, Li X
Journal of dairy science 2024 May;107(5):3269-3279
Journal of dairy science 2024 May;107(5):3269-3279
Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy.
Lin ZH, Xiang HQ, Yu YW, Xue YJ, Wu C, Lin C, Ji KT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23677
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23677
DADLE promotes motor function recovery by inhibiting cytosolic phospholipase A(2) mediated lysosomal membrane permeabilization after spinal cord injury.
Chen Y, Zhang H, Jiang L, Cai W, Kuang J, Geng Y, Xu H, Li Y, Yang L, Cai Y, Wang X, Xiao J, Ni W, Zhou K
British journal of pharmacology 2024 Mar;181(5):712-734
British journal of pharmacology 2024 Mar;181(5):712-734
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
Chen C, Zhang Z, Liu C, Sun P, Liu P, Li X
Cell metabolism 2024 Mar 5;36(3):498-510.e11
Cell metabolism 2024 Mar 5;36(3):498-510.e11
SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion.
Zhang J, Kennedy A, de Melo Jorge DM, Xing L, Reid W, Bui S, Joppich J, Rose M, Ercan S, Tang Q, Tai AW, Wang Y
bioRxiv : the preprint server for biology 2024 Mar 15;
bioRxiv : the preprint server for biology 2024 Mar 15;
Loss of the Golgi-localized v-ATPase subunit does not alter insulin granule formation or pancreatic islet β-cell function.
Boyer CK, Blom SE, Machado AE, Rohli KE, Maxson ME, Stephens SB
American journal of physiology. Endocrinology and metabolism 2024 Mar 1;326(3):E245-E257
American journal of physiology. Endocrinology and metabolism 2024 Mar 1;326(3):E245-E257
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Gu M, Li C, Deng Q, Chen X, Lei R
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions.
Hou Y, Chu X, Park JH, Zhu Q, Hussain M, Li Z, Madsen HB, Yang B, Wei Y, Wang Y, Fang EF, Croteau DL, Bohr VA
Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Jun;20(6):4212-4233
Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Jun;20(6):4212-4233
scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network.
Li C, Shao X, Zhang S, Wang Y, Jin K, Yang P, Lu X, Fan X, Wang Y
Cell reports. Medicine 2024 Jun 18;5(6):101568
Cell reports. Medicine 2024 Jun 18;5(6):101568
Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3.
Abe M, Masuda M, Mizukami Y, Inoue S, Mizutani Y
The Journal of biological chemistry 2024 Jul;300(7):107449
The Journal of biological chemistry 2024 Jul;300(7):107449
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps.
Lai Y, Yang N, Shi D, Ma X, Huang Y, Lu J, Zhang X, Zhou H, Gao W, Mao C, Wang L
European journal of pharmacology 2024 Jul 5;974:176621
European journal of pharmacology 2024 Jul 5;974:176621
Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745(T) induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in non-small cell lung cancer cell lines.
Lin X, Dong L, Miao Q, Huang Z, Wang F
European journal of pharmacology 2024 Jul 5;974:176608
European journal of pharmacology 2024 Jul 5;974:176608
Exploring the inhibitory impact of Mongolian medicinal He-Zi-3 soup on mammary gland hyperplasia in rats induced by estrogen and progestogen.
Liang C, Mu X, Bao Q, Borzigin P, Sheng H, Han X, Chen Y, Wang T
Journal of ethnopharmacology 2024 Jul 15;329:117854
Journal of ethnopharmacology 2024 Jul 15;329:117854
FGF-18 Protects the Injured Spinal cord in mice by Suppressing Pyroptosis and Promoting Autophagy via the AKT-mTOR-TRPML1 axis.
Li F, Cai T, Yu L, Yu G, Zhang H, Geng Y, Kuang J, Wang Y, Cai Y, Xiao J, Wang X, Ding J, Xu H, Ni W, Zhou K
Molecular neurobiology 2024 Jan;61(1):55-73
Molecular neurobiology 2024 Jan;61(1):55-73
Acetylation of MOB1 mediates polyphyllin II-reduced lysosome biogenesis in breast cancer by promoting the cytoplasmic retention of the YAP/TFEB coactivator complex.
Ren Y, Wu H, Tan M, Chen J, Duan Z, Zhu B, Ruan X, Yu Q, Li S, Liu X, Liu Y, Si Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155152
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155152
Coxiella burnetii effector CvpE maintains biogenesis of Coxiella-containing vacuoles by suppressing lysosome tubulation through binding PI(3)P and perturbing PIKfyve activity on lysosomes.
Zhao M, Zhang S, Wan W, Zhou C, Li N, Cheng R, Yu Y, Ouyang X, Zhou D, Jiao J, Xiong X
Virulence 2024 Dec;15(1):2350893
Virulence 2024 Dec;15(1):2350893
Molecular Insights into the Regulation of GNPTAB by TMEM251.
Yang X, Doray B, Venkatarangan V, Jennings BC, Henn D, Liang J, Zhao H, Zhang W, Zhang B, Yu L, Chen L, Kornfeld S, Li M
bioRxiv : the preprint server for biology 2024 Dec 5;
bioRxiv : the preprint server for biology 2024 Dec 5;
PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease.
Cao B, Chen X, Li Y, Zhou T, Chen N, Guo Y, Zhao M, Guo C, Shi Y, Wang Q, Du X, Zhang L, Li Y
NPJ Parkinson's disease 2024 Aug 6;10(1):146
NPJ Parkinson's disease 2024 Aug 6;10(1):146
A snake cathelicidin enhances transcription factor EB-mediated autophagy and alleviates ROS-induced pyroptosis after ischaemia-reperfusion injury of island skin flaps.
Yang N, Yu G, Lai Y, Zhao J, Chen Z, Chen L, Fu Y, Fang P, Gao W, Cai Y, Li Z, Xiao J, Zhou K, Ding J
British journal of pharmacology 2024 Apr;181(7):1068-1090
British journal of pharmacology 2024 Apr;181(7):1068-1090
Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury.
Zheng B, He Y, Yin S, Zhu X, Zhao Q, Yang H, Wang Z, Zhu R, Cheng L
Research (Washington, D.C.) 2023;6:0135
Research (Washington, D.C.) 2023;6:0135
Common Markers and Small Molecule Inhibitors in Golgi Studies.
Bui S, Stark D, Li J, Zhang J, Wang Y
Methods in molecular biology (Clifton, N.J.) 2023;2557:453-493
Methods in molecular biology (Clifton, N.J.) 2023;2557:453-493
Immunofluorescence Microscopy of the Mammalian Golgi Apparatus.
Arab M, Nayak SC, Vitali T, Lowe M
Methods in molecular biology (Clifton, N.J.) 2023;2557:101-111
Methods in molecular biology (Clifton, N.J.) 2023;2557:101-111
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, Wei HL, Zhang C, Wang Z, Kong LM, Chen ZN, Bian H
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.
Yu H, Hao Z, Liu X, Wei Z, Tan R, Liu X, Chen Q, Chen Y, Zhou H, Liu Y, Fu Z
Environmental toxicology 2023 Sep;38(9):2100-2110
Environmental toxicology 2023 Sep;38(9):2100-2110
Astrocytic AT1R deficiency ameliorates Aβ-induced cognitive deficits and synaptotoxicity through β-arrestin2 signaling.
Chen X, Gao R, Song Y, Xu T, Jin L, Zhang W, Chen Z, Wang H, Wu W, Zhang S, Zhang G, Zhang N, Chang L, Liu H, Li H, Wu Y
Progress in neurobiology 2023 Sep;228:102489
Progress in neurobiology 2023 Sep;228:102489
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
Song D, Tao W, Liu F, Wu X, Bi H, Shu J, Wang D, Li X
Molecular immunology 2023 Nov;163:127-135
Molecular immunology 2023 Nov;163:127-135
Rosuvastatin promotes survival of random skin flaps through AMPK-mTOR pathway-induced autophagy.
Ye H, Li F, Shen Y, Wu X, Zhao L, Zhang H, Yang J, Shui X
International immunopharmacology 2023 May;118:110059
International immunopharmacology 2023 May;118:110059
Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health.
Daly JL, Danson CM, Lewis PA, Zhao L, Riccardo S, Di Filippo L, Cacchiarelli D, Lee D, Cross SJ, Heesom KJ, Xiong WC, Ballabio A, Edgar JR, Cullen PJ
Nature communications 2023 May 29;14(1):3086
Nature communications 2023 May 29;14(1):3086
Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect.
Hao Y, Song T, Wang M, Li T, Zhao C, Li T, Hou Y, He H
International journal of oncology 2023 Mar;62(3)
International journal of oncology 2023 Mar;62(3)
A novel selective estrogen receptor degrader induces cell cycle arrest in breast cancer via ERα degradation and the autophagy-lysosome pathway.
Zhou J, Shen R, Liu J, Deng X, Xin L, Zhou HB, Huang J
Bioorganic & medicinal chemistry 2023 Mar 15;82:117235
Bioorganic & medicinal chemistry 2023 Mar 15;82:117235
Exercise pretreatment alleviates neuroinflammation and oxidative stress by TFEB-mediated autophagic flux in mice with ischemic stroke.
Zhao Y, Hong Z, Lin Y, Shen W, Yang Y, Zuo Z, Hu X
Experimental neurology 2023 Jun;364:114380
Experimental neurology 2023 Jun;364:114380
Nuciferine improves random skin flap survival via TFEB-mediated activation of autophagy-lysosomal pathway.
Xue K, Zhang G, Zhou Y, Wang K, Yao Z, Chen J, Zhang Y, Li Z, Li Z, Zheng Z, Feng Y, Mao C, Lin C, Xia W
International immunopharmacology 2023 Jun;119:110204
International immunopharmacology 2023 Jun;119:110204
Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization.
Zhang H, Chen Y, Li F, Wu C, Cai W, Ye H, Su H, He M, Yang L, Wang X, Zhou K, Ni W
Journal of neuroinflammation 2023 Jan 7;20(1):6
Journal of neuroinflammation 2023 Jan 7;20(1):6
Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement.
Zhang H, Wu C, Yu DD, Su H, Chen Y, Ni W
Phytotherapy research : PTR 2023 Feb;37(2):438-451
Phytotherapy research : PTR 2023 Feb;37(2):438-451
Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons.
Hasan S, Fernandopulle MS, Humble SW, Frankenfield AM, Li H, Prestil R, Johnson KR, Ryan BJ, Wade-Martins R, Ward ME, Hao L
bioRxiv : the preprint server for biology 2023 Feb 24;
bioRxiv : the preprint server for biology 2023 Feb 24;
Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells.
Liu Y, Sun Y, Xu Y, Dong T, Qian L, Zheng H, Gao Y, Chu Z, Fu X, Zhang H, Xie F, Zhang C, Tang Y, Lou H
Cell chemical biology 2023 Feb 16;30(2):130-143.e5
Cell chemical biology 2023 Feb 16;30(2):130-143.e5
HD-sEVs in bovine follicular fluid regulate granulosa cell apoptosis and estradiol secretion through the autophagy pathway.
Wang Y, Zhao Y, Ling Z, Luan D, Kang J, Dong X, Quan F
Theriogenology 2023 Dec;212:91-103
Theriogenology 2023 Dec;212:91-103
Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury.
Xu Y, Geng Y, Wang H, Zhang H, Qi J, Li F, Hu X, Chen Y, Si H, Li Y, Wang X, Xu H, Kong J, Cai Y, Wu A, Ni W, Xiao J, Zhou K
Redox biology 2023 Aug;64:102767
Redox biology 2023 Aug;64:102767
Narirutin activates TFEB (transcription factor EB) to protect against Acetaminophen-induced liver injury by targeting PPP3/calcineurin.
Fang Z, Xu Y, Liu G, Shao Q, Niu X, Tai W, Shen T, Fan M, Chen M, Lei L, Gao W, Song Y, Wang Z, Du X, Li X
Autophagy 2023 Aug;19(8):2240-2256
Autophagy 2023 Aug;19(8):2240-2256
Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma.
Zhang Z, Shi Y, Zhu Z, Fu J, Liu D, Liu X, Dang J, Tao H, Fan H
Cancer science 2023 Apr;114(4):1240-1255
Cancer science 2023 Apr;114(4):1240-1255
Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain.
Suk TR, Nguyen TT, Fisk ZA, Mitkovski M, Geertsma HM, Parmasad JA, Heer MM, Callaghan SM, Benseler F, Brose N, Tirard M, Rousseaux MWC
iScience 2023 Apr 21;26(4):106350
iScience 2023 Apr 21;26(4):106350
Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy.
Jiang RH, Dong CJ, Chen ZL, Cheng S, Yang JX, Gao WY
Oxidative medicine and cellular longevity 2022;2022:5668226
Oxidative medicine and cellular longevity 2022;2022:5668226
Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.
Li Z, Wang T, Xin C, Song Y, Kong J, Xu J, Liu Q, Teng Y, Hou N, Cheng X, Yang G, Liu W, Zhou B, Zhang Y, Yang X, Wang J
International journal of biological sciences 2022;18(5):2018-2031
International journal of biological sciences 2022;18(5):2018-2031
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
Nature communications 2022 Sep 12;13(1):5351
Nature communications 2022 Sep 12;13(1):5351
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.
Zhou Z, Wang H, Zhang X, Song M, Yao S, Jiang P, Liu D, Wang Z, Lv H, Li R, Hong Y, Dai J, Hu Y, Zhao G
Autophagy 2022 Oct;18(10):2427-2442
Autophagy 2022 Oct;18(10):2427-2442
Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo.
Singh J, Elhabashy H, Muthukottiappan P, Stepath M, Eisenacher M, Kohlbacher O, Gieselmann V, Winter D
Nature communications 2022 Oct 20;13(1):6212
Nature communications 2022 Oct 20;13(1):6212
Moderate Treadmill Exercise Alleviates NAFLD by Regulating the Biogenesis and Autophagy of Lipid Droplet.
Yang Y, Li X, Liu Z, Ruan X, Wang H, Zhang Q, Cao L, Song L, Chen Y, Sun Y
Nutrients 2022 Nov 20;14(22)
Nutrients 2022 Nov 20;14(22)
Paeonol protects renal tubular cells against cadmium-induced cytotoxicity via alleviating oxidative stress, inhibiting inflammatory responses and restoring autophagy.
Liu W, Gong Z, Zhang K, Dong W, Zou H, Song R, Bian J, Zhu J, Liu G, Liu Z
Journal of inorganic biochemistry 2022 May;230:111733
Journal of inorganic biochemistry 2022 May;230:111733
Wolframin is a novel regulator of tau pathology and neurodegeneration.
Chen S, Acosta D, Li L, Liang J, Chang Y, Wang C, Fitzgerald J, Morrison C, Goulbourne CN, Nakano Y, Villegas NCH, Venkataraman L, Brown C, Serrano GE, Bell E, Wemlinger T, Wu M, Kokiko-Cochran ON, Popovich P, Flowers XE, Honig LS, Vonsattel JP, Scharre DW, Beach TG, Ma Q, Kuret J, Kõks S, Urano F, Duff KE, Fu H
Acta neuropathologica 2022 May;143(5):547-569
Acta neuropathologica 2022 May;143(5):547-569
Overactivation of hepatic mechanistic target of rapamycin kinase complex 1 (mTORC1) is associated with low transcriptional activity of transcription factor EB and lysosomal dysfunction in dairy cows with clinical ketosis.
Fang Z, Li X, Wang S, Jiang Q, Loor JJ, Jiang X, Ju L, Yu H, Shen T, Chen M, Song Y, Wang Z, Du X, Liu G
Journal of dairy science 2022 May;105(5):4520-4533
Journal of dairy science 2022 May;105(5):4520-4533
Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.
Han X, Tang Y, Zhang Y, Zhang J, Hu Z, Xu W, Xu S, Niu Q
Ecotoxicology and environmental safety 2022 May 1;236:113500
Ecotoxicology and environmental safety 2022 May 1;236:113500
GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke.
Zhang Y, Wu Z, Huang Z, Liu Y, Chen X, Zhao X, He H, Deng Y
Brain research 2022 Mar 1;1778:147768
Brain research 2022 Mar 1;1778:147768
Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway.
Du X, Di Malta C, Fang Z, Shen T, Niu X, Chen M, Jin B, Yu H, Lei L, Gao W, Song Y, Wang Z, Xu C, Cao Z, Liu G, Li X
Acta pharmaceutica Sinica. B 2022 Jun;12(6):2869-2886
Acta pharmaceutica Sinica. B 2022 Jun;12(6):2869-2886
EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer.
Wang J, Wren JD, Ding Y, Chen J, Mittal N, Xu C, Li X, Zeng C, Wang M, Shi J, Zhang YH, Han SJ, Zhang XA
Cancer letters 2022 Jun 28;536:215641
Cancer letters 2022 Jun 28;536:215641
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Simonetti B, Daly JL, Simón-Gracia L, Klein K, Weeratunga S, Antón-Plágaro C, Tobi A, Hodgson L, Lewis PA, Heesom KJ, Shoemark DK, Davidson AD, Collins BM, Teesalu T, Yamauchi Y, Cullen PJ
Proceedings of the National Academy of Sciences of the United States of America 2022 Jun 21;119(25):e2201980119
Proceedings of the National Academy of Sciences of the United States of America 2022 Jun 21;119(25):e2201980119
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Lou J, Zhang H, Qi J, Xu Y, Wang X, Jiang J, Hu X, Ni L, Cai Y, Wang X, Gao W, Xiao J, Zhou K
British journal of pharmacology 2022 Jan;179(2):301-321
British journal of pharmacology 2022 Jan;179(2):301-321
Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress.
Gong ZG, Zhao Y, Wang ZY, Fan RF, Liu ZP, Wang L
Journal of hazardous materials 2022 Feb 5;423(Pt A):127110
Journal of hazardous materials 2022 Feb 5;423(Pt A):127110
mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species.
Hosios AM, Wilkinson ME, McNamara MC, Kalafut KC, Torrence ME, Asara JM, Manning BD
Nature metabolism 2022 Dec;4(12):1792-1811
Nature metabolism 2022 Dec;4(12):1792-1811
Activated autophagy-lysosomal pathway in dairy cows with hyperketonemia is associated with lipolysis of adipose tissues.
Yu H, Fan M, Chen X, Jiang X, Loor JJ, Aboragah A, Zhang C, Bai H, Fang Z, Shen T, Wang Z, Song Y, Li X, Liu G, Li X, Du X
Journal of dairy science 2022 Aug;105(8):6997-7010
Journal of dairy science 2022 Aug;105(8):6997-7010
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
Zhang Z, Chen C, Yang F, Zeng YX, Sun P, Liu P, Li X
Molecular cell 2022 Aug 4;82(15):2844-2857.e10
Molecular cell 2022 Aug 4;82(15):2844-2857.e10
Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses.
Luo Q, Liu Q, Cheng H, Wang J, Zhao T, Zhang J, Mu C, Meng Y, Chen L, Zhou C, Lei H, Yang J, Chen G, Li Y, Pan L, Chen Q, Zhu Y
Cell reports 2022 Aug 16;40(7):111195
Cell reports 2022 Aug 16;40(7):111195
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca(2+)-PPP3/calcineurin-TFEB axis.
Zummo FP, Krishnanda SI, Georgiou M, O'Harte FP, Parthsarathy V, Cullen KS, Honkanen-Scott M, Shaw JA, Lovat PE, Arden C
Autophagy 2022 Apr;18(4):799-815
Autophagy 2022 Apr;18(4):799-815
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.
Yu YW, Que JQ, Liu S, Huang KY, Qian L, Weng YB, Rong FN, Wang L, Zhou YY, Xue YJ, Ji KT
Frontiers in cardiovascular medicine 2021;8:768214
Frontiers in cardiovascular medicine 2021;8:768214
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Xu Y, Hu X, Li F, Zhang H, Lou J, Wang X, Wang H, Yin L, Ni W, Kong J, Wang X, Li Y, Zhou K, Xu H
Oxidative medicine and cellular longevity 2021;2021:8186877
Oxidative medicine and cellular longevity 2021;2021:8186877
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Zhu X, Hu X, Lou J, Li J, Xu Y, Yu G, Wu C, Ding J, Gao W, Xiao J, Zhou K, Jia C
Oxidative medicine and cellular longevity 2021;2021:6610603
Oxidative medicine and cellular longevity 2021;2021:6610603
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.
Wu C, Chen H, Zhuang R, Zhang H, Wang Y, Hu X, Xu Y, Li J, Li Y, Wang X, Xu H, Ni W, Zhou K
International journal of biological sciences 2021;17(4):1138-1152
International journal of biological sciences 2021;17(4):1138-1152
Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media.
Xie D, Zhao T, Zhang X, Kui L, Wang Q, Wu Y, Zheng T, Ma P, Zhang Y, Molteni H, Geng R, Yang Y, Li B, Zheng QY
Frontiers in cellular neuroscience 2021;15:753369
Frontiers in cellular neuroscience 2021;15:753369
Curcumin promotes the survival of ischemic random skin flaps via autophagy.
Tu Z, Jiang X, Li Y, Yang S, Lin D, Shi Y, Mao C, Zhang X, Lin C
American journal of translational research 2021;13(3):1337-1351
American journal of translational research 2021;13(3):1337-1351
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
Zhou F, Zhang X, Jiang L, Li S, Chen Y, Wu J
Frontiers in pharmacology 2021;12:667524
Frontiers in pharmacology 2021;12:667524
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Wang J, Su Q, Wu Q, Chen K, Ullah A, Ghauri MA, Zhang Y
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Archives of pharmacal research 2021 Nov;44(11):1025-1036
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Fan Y, Lu J, Liu J, Zhang R, Yu Z, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Prenatal-onset of congenital neuronal ceroid lipofuscinosis with a novel CTSD mutation.
Chartier S, Boutaud L, Le Guillou E, Alby C, Billon C, Millischer AE, Caillaud C, Galmiche L, Mechler C, Sonigo P, Boddaert N, Lyonnet S, Rondeau S, Bole-Feysot C, Masson C, Ville Y, Roth P, Desguerre I, Encha-Razavi F, Attie-Bitach T
Birth defects research 2021 Nov;113(18):1324-1332
Birth defects research 2021 Nov;113(18):1324-1332
Exopolysaccharides from Bifidobacterium animalis Ameliorate Escherichia coli-Induced IPEC-J2 Cell Damage via Inhibiting Apoptosis and Restoring Autophagy.
Yuan L, Chu B, Chen S, Li Y, Liu N, Zhu Y, Zhou D
Microorganisms 2021 Nov 16;9(11)
Microorganisms 2021 Nov 16;9(11)
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Li J, Chen H, Lou J, Bao G, Wu C, Lou Z, Wang X, Ding J, Li Z, Xiao J, Xu H, Gao W, Zhou K
Journal of cellular physiology 2021 May;236(5):3641-3659
Journal of cellular physiology 2021 May;236(5):3641-3659
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Zhang X, Wei M, Fan J, Yan W, Zha X, Song H, Wan R, Yin Y, Wang W
Autophagy 2021 Jun;17(6):1519-1542
Autophagy 2021 Jun;17(6):1519-1542
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Hossain MI, Marcus JM, Lee JH, Garcia PL, Singh V, Shacka JJ, Zhang J, Gropen TI, Falany CN, Andrabi SA
Autophagy 2021 Jun;17(6):1330-1348
Autophagy 2021 Jun;17(6):1330-1348
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models.
Dong WL, Zhong JH, Chen YQ, Xie JF, Qin YY, Xu JP, Cai NB, Li MF, Liu L, Wang HT
Acta pharmacologica Sinica 2021 Dec;42(12):1991-2003
Acta pharmacologica Sinica 2021 Dec;42(12):1991-2003
Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD.
Wu Y, Shao W, Todd TW, Tong J, Yue M, Koga S, Castanedes-Casey M, Librero AL, Lee CW, Mackenzie IR, Dickson DW, Zhang YJ, Petrucelli L, Prudencio M
Cell reports 2021 Aug 24;36(8):109581
Cell reports 2021 Aug 24;36(8):109581
Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.
Chen X, Guan Y, Zhang Y, Jia Y, Li W, Guo C, Li Y, Wang X, Shi Y, Wang Q, Zhu F, Li Y, Zhang L
Cell death and differentiation 2021 Apr;28(4):1237-1250
Cell death and differentiation 2021 Apr;28(4):1237-1250
DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.
Cao Y, Li R, Shen M, Li C, Zou Y, Jiang Q, Liu S, Lu C, Li H, Liu H, Cai Y
Cell death & disease 2021 Apr 20;12(5):416
Cell death & disease 2021 Apr 20;12(5):416
TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7.
Hu J, Ding X, Tian S, Chu Y, Liu Z, Li Y, Li X, Wang G, Wang L, Wang Z
Cell death & disease 2021 Apr 12;12(4):391
Cell death & disease 2021 Apr 12;12(4):391
Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.
Zhang C, Shao Z, Chen Z, Lin C, Hu S, Lou Z, Li J, Zheng X, Lin N, Gao W
American journal of translational research 2020;12(8):4781-4794
American journal of translational research 2020;12(8):4781-4794
Detrimental Effect of Sitagliptin Induced Autophagy on Multiterritory Perforator Flap Survival.
Chen Z, Zhang C, Ma H, Huang Z, Li J, Lou J, Li B, Tu Q, Gao W
Frontiers in pharmacology 2020;11:951
Frontiers in pharmacology 2020;11:951
Staphylococcus aureus Avoids Autophagy Clearance of Bovine Mammary Epithelial Cells by Impairing Lysosomal Function.
Geng N, Wang X, Yu X, Wang R, Zhu Y, Zhang M, Liu J, Liu Y
Frontiers in immunology 2020;11:746
Frontiers in immunology 2020;11:746
Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.
Li B, Chen Z, Luo X, Zhang C, Chen H, Wang S, Zhao M, Ma H, Liu J, Cheng M, Yang Y, Yan H
Frontiers in pharmacology 2020;11:612932
Frontiers in pharmacology 2020;11:612932
Notoginsenoside R1 Protects Against the Acrylamide-Induced Neurotoxicity via Upregulating Trx-1-Mediated ITGAV Expression: Involvement of Autophagy.
Wang W, Huang L, Thomas ER, Hu Y, Zeng F, Li X
Frontiers in pharmacology 2020;11:559046
Frontiers in pharmacology 2020;11:559046
Baicalein Attenuates Pyroptosis and Endoplasmic Reticulum Stress Following Spinal Cord Ischemia-Reperfusion Injury via Autophagy Enhancement.
Wu C, Xu H, Li J, Hu X, Wang X, Huang Y, Li Y, Sheng S, Wang Y, Xu H, Ni W, Zhou K
Frontiers in pharmacology 2020;11:1076
Frontiers in pharmacology 2020;11:1076
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W, Liu M, Xie L, Zhang H, Xu H, Xiao J
Theranostics 2020;10(20):9280-9302
Theranostics 2020;10(20):9280-9302
Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.
Yang Y, Wang Q, Song D, Zen R, Zhang L, Wang Y, Yang H, Zhang D, Jia J, Zhang J, Wang J
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):197
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):197
Autophagic blockage by bismuth sulfide nanoparticles inhibits migration and invasion of HepG2 cells.
Hao BM, Liu YN, Zhang CY, Li GQ, Wang WN, Xu WD, Zha ZB, Wang F, Li C, Miao ZH, Yang XX, Chen YL, Qian HS, Zhou W
Nanotechnology 2020 Nov 13;31(46):465102
Nanotechnology 2020 Nov 13;31(46):465102
Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens.
Cui X, Feng R, Wang J, Du C, Pi X, Chen D, Li J, Li H, Zhang J, Zhang J, Mu H, Zhang F, Liu M, Hu Y
Biochimica et biophysica acta. General subjects 2020 Mar;1864(3):129496
Biochimica et biophysica acta. General subjects 2020 Mar;1864(3):129496
An Experimental Model of Neurodegenerative Disease Based on Porcine Hemagglutinating Encephalomyelitis Virus-Related Lysosomal Abnormalities.
Lan Y, Li Z, Wang Z, Wang X, Wang G, Zhang J, Hu S, Zhao K, Xu B, Gao F, He W
Molecular neurobiology 2020 Dec;57(12):5299-5306
Molecular neurobiology 2020 Dec;57(12):5299-5306
Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis.
Chen M, Ding Y, Ke Y, Zeng Y, Liu N, Zhong Y, Hua X, Li Z, Xiong Y, Wu C, Yu H
Artificial cells, nanomedicine, and biotechnology 2020 Dec;48(1):824-833
Artificial cells, nanomedicine, and biotechnology 2020 Dec;48(1):824-833
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Guan S, Tao S, Huang Y, Jin Y, Hu Y, Lu J
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting.
Evans AJ, Daly JL, Anuar ANK, Simonetti B, Cullen PJ
Journal of cell science 2020 Aug 3;133(15)
Journal of cell science 2020 Aug 3;133(15)
Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.
Wu H, Ding J, Li S, Lin J, Jiang R, Lin C, Dai L, Xie C, Lin D, Xu H, Gao W, Zhou K
International journal of biological sciences 2019;15(2):325-340
International journal of biological sciences 2019;15(2):325-340
27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells.
Chen S, Zhou C, Yu H, Tao L, An Y, Zhang X, Wang Y, Wang Y, Xiao R
Frontiers in molecular neuroscience 2019;12:14
Frontiers in molecular neuroscience 2019;12:14
Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, Li S, Wang Y, Lin D, Gao W, Kong J, Xu H, Zhou K
American journal of translational research 2019;11(1):379-392
American journal of translational research 2019;11(1):379-392
Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.
Li J, Bao G, ALyafeai E, Ding J, Li S, Sheng S, Shen Z, Jia Z, Lin C, Zhang C, Lou Z, Xu H, Gao W, Zhou K
Frontiers in pharmacology 2019;10:1017
Frontiers in pharmacology 2019;10:1017
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
Zhou K, Chen H, Lin J, Xu H, Wu H, Bao G, Li J, Deng X, Shui X, Gao W, Ding J, Xiao J, Xu H
Cell death & disease 2019 Nov 18;10(12):872
Cell death & disease 2019 Nov 18;10(12):872
Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk.
Sheng J, Shen L, Sun L, Zhang X, Cui R, Wang L
Cell proliferation 2019 May;52(3):e12609
Cell proliferation 2019 May;52(3):e12609
ERβ promotes Aβ degradation via the modulation of autophagy.
Wei Y, Zhou J, Wu J, Huang J
Cell death & disease 2019 Jul 22;10(8):565
Cell death & disease 2019 Jul 22;10(8):565
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, Li S, Wang Y, Lin D, Gao W, Kong J, Xu H, Zhou K
Frontiers in pharmacology 2018;9:1178
Frontiers in pharmacology 2018;9:1178
NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy.
Wang H, Li W, Xu J, Zhang T, Zuo D, Zhou Z, Lin B, Wang G, Wang Z, Sun W, Sun M, Chang S, Cai Z, Hua Y
Cell death & disease 2017 Sep 14;8(9):e3048
Cell death & disease 2017 Sep 14;8(9):e3048
Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux.
Xie X, Yi W, Zhang P, Wu N, Yan Q, Yang H, Tian C, Xiang S, Du M, Getachew Assefa E, Zuo X, Ying C
Nutrients 2017 May 14;9(5)
Nutrients 2017 May 14;9(5)
TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.
Jinn S, Drolet RE, Cramer PE, Wong AH, Toolan DM, Gretzula CA, Voleti B, Vassileva G, Disa J, Tadin-Strapps M, Stone DJ
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 28;114(9):2389-2394
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 28;114(9):2389-2394
Epigallocatechin-3-gallate inhibits H(2)O(2)-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor.
Yan X, Li Y, Yu H, Wang W, Wu C, Yang Y, Hu Y, Shi X, Li J
Scientific reports 2017 Aug 10;7(1):7774
Scientific reports 2017 Aug 10;7(1):7774
Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species.
Wang H, Liu T, Li L, Wang Q, Yu C, Liu X, Li W
Cell & bioscience 2015;5:4
Cell & bioscience 2015;5:4
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, Liu X, Li W
British journal of pharmacology 2015 May;172(9):2232-45
British journal of pharmacology 2015 May;172(9):2232-45
Citreoviridin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis in Human Liver HepG2 Cells.
Wang Y, Liu Y, Liu X, Jiang L, Yang G, Sun X, Geng C, Li Q, Yao X, Chen M
Toxins 2015 Aug 6;7(8):3030-44
Toxins 2015 Aug 6;7(8):3030-44
Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells.
Liu T, Men Q, Wu G, Yu C, Huang Z, Liu X, Li W
Oncotarget 2015 Apr 10;6(10):7992-8006
Oncotarget 2015 Apr 10;6(10):7992-8006
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.
Shu G, Mi X, Cai J, Zhang X, Yin W, Yang X, Li Y, Chen L, Deng X
Toxicology letters 2013 Oct 24;222(2):91-101
Toxicology letters 2013 Oct 24;222(2):91-101
Proteomic features of potential tumor suppressor NESG1 in nasopharyngeal carcinoma.
Liu Z, Chen C, Yang H, Zhang Y, Long J, Long X, Fang W
Proteomics 2012 Nov;12(22):3416-25
Proteomics 2012 Nov;12(22):3416-25
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 21327-1-AP(CTSD antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CTSD antibody 21327-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human hepatocirrhosis using 21327-1-AP(CTSD antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human hepatocirrhosis using 21327-1-AP(CTSD antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
