66534-1-Ig

antibody from Proteintech Group

Targeting: CTSD CLN10, CPSD

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

66534-1-Ig

Provider

Proteintech Group

Product name

Cathepsin D antibody

Antibody type

Monoclonal

Description

Cathepsin D antibody (Cat. #66534-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: FC, IF, IHC, WB, ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2F6F7

Vial size

20ul, 150ul

References

Submitted references

Proteomic Characterization Identifies Clinically Relevant Subgroups of Gastrointestinal Stromal Tumors.

Sun M, Tong Y, Yuan W, Wang Y, Pu Y, Huang W, Lv B, Xu C, Jiang W, Luo R, Fang R, Tang S, Ren L, Wang J, Feng J, Sun C, Shen K, He F, Hou Y, Ding C
Gastroenterology 2024 Mar;166(3):450-465.e33

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Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation.

Ma Y, Xu P, Xing H, Zhang Y, Li T, Ding X, Liu L, Niu Q
Ecotoxicology and environmental safety 2024 Apr 1;274:116195

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TFE3-mediated impairment of lysosomal biogenesis and defective autophagy contribute to fluoride-induced hepatotoxicity.

Hu Z, Xu W, Zhang J, Tang Y, Xing H, Xu P, Ma Y, Niu Q
Ecotoxicology and environmental safety 2023 Mar 15;253:114674

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The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity.

Zhang J, Tang Y, Hu Z, Xu W, Ma Y, Xu P, Xing H, Niu Q
Ecotoxicology and environmental safety 2023 Jan 15;250:114511

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Senile plaques in Alzheimer's disease arise from Aβ- and Cathepsin D-enriched mixtures leaking out during intravascular haemolysis and microaneurysm rupture.

Fu H, Li J, Du P, Jin W, Gao G, Cui D
FEBS letters 2023 Apr;597(7):1007-1040

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Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis.

Ding P, Xu Y, Li L, Lv X, Li L, Chen J, Zhou D, Wang X, Wang Q, Zhang W, Liao T, Ji QH, Lei QY, Hu W
Cell reports 2022 May 31;39(9):110851

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Melibiose Confers a Neuroprotection against Cerebral Ischemia/Reperfusion Injury by Ameliorating Autophagy Flux via Facilitation of TFEB Nuclear Translocation in Neurons.

Wu Z, Zhang Y, Liu Y, Chen X, Huang Z, Zhao X, He H, Deng Y
Life (Basel, Switzerland) 2021 Sep 10;11(9)

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Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation.

Okuyama K, Kitajima Y, Egawa N, Kitagawa H, Ito K, Aishima S, Yanagihara K, Tanaka T, Noshiro H
Scientific reports 2019 Feb 26;9(1):2822