AGTO-L010S

antibody from Creative Biolabs

Targeting: DBH DBM

Functional assay (Recommended by provider)

Antibody Data

Product number

AGTO-L010S

Provider

Creative Biolabs

Product name

anti-DBH immunotoxin 4F10.2 (IgG)-Sap

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-DBH monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to neuronal cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of neuroblastoma.

Reactivity

Human

Host

Mouse