11128-1-AP

antibody from Proteintech Group

Targeting: MYH9 DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHCA

Provider product page for 11128-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [33]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 11128-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11128-1-AP, RRID:AB_2147294
Product name: MYH9 antibody
Antibody type: Polyclonal
Description: KD/KO validated MYH9 antibody (Cat. #11128-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MYH9 protein structure - 11128-1-AP shown in red.

Submitted references PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes.

Pang R, Sun W, Yang Y, Wen D, Lin F, Wang D, Li K, Zhang N, Liang J, Xiong C, Liu Y
Nature biomedical engineering 2024 Sep;8(9):1162-1176

NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.

Wang Y, Liu X, Zuo X, Wang C, Zhang Z, Zhang H, Zeng T, Chen S, Liu M, Chen H, Song Q, Li Q, Yang C, Le Y, Xing J, Zhang H, An J, Jia W, Kang L, Zhang H, Xie H, Ye J, Wu T, He F, Zhang X, Li Y, Zhou G
Cell genomics 2024 May 8;4(5):100550

Pseudorabies virus usurps non-muscle myosin heavy chain IIA to dampen viral DNA recognition by cGAS for antagonism of host antiviral innate immunity.

Liu Y, Qin Y, Yang B, Zheng H, Qiao S, Luo Z, Li R
Journal of virology 2024 May 14;98(5):e0048324

Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity.

Zhang X, Pant SM, Ritch CC, Tang HY, Shao H, Dweep H, Gong YY, Brooks R, Brafford P, Wolpaw AJ, Lee Y, Weeraratna A, Sehgal A, Herlyn M, Kossenkov A, Speicher D, Sorger PK, Santagata S, Dang CV
Nature communications 2024 Jan 20;15(1):633

Ruscogenin Alleviates Myocardial Ischemia via Myosin IIA-Dependent Mitochondrial Fusion and Fission Balance.

Liu JC, Zhao QF, Zhang L, Yu BY, Li F, Kou JP
The American journal of Chinese medicine 2023;51(7):1879-1904

Comprehensive analysis of transcriptome-wide N6-methyladenosine methylomes in the Barrett's esophagus in rats.

Zou K, Dong H, Li M, Zhang Y, Zhang K, Song D, Chu C
Genomics 2023 Sep;115(5):110687

Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells.

Liu Y, Yao X, Zhao Y, Fang D, Shi L, Yang L, Song G, Cai K, Li L, Deng Q, Li M, Luo Z
Cell reports 2023 Oct 31;42(10):113213

DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation.

Zhang Q, Feng P, Zhu XH, Zhou SQ, Ye ML, Yang XJ, Gong S, Huang SY, Tan XR, He SW, Li YQ
Cell death & disease 2023 Oct 24;14(10):697

Chiral Cell Nanomechanics Originated in Clockwise/Counterclockwise Biofunctional Microarrays to Govern the Nuclear Mechanotransduction of Mesenchymal Stem Cells.

Wang Y, Tong X, Shi X, Keswani T, Chatterjee E, Chen L, Li G, Lee K, Guo T, Yu Y
ACS applied materials & interfaces 2023 Oct 18;15(41):48038-48049

Pyruvate kinase M2 regulates mitochondrial homeostasis in cisplatin-induced acute kidney injury.

Xie W, He Q, Zhang Y, Xu X, Wen P, Cao H, Zhou Y, Luo J, Yang J, Jiang L
Cell death & disease 2023 Oct 10;14(10):663

Improved in situ characterization of protein complex dynamics at scale with thermal proximity co-aggregation.

Sun S, Zheng Z, Wang J, Li F, He A, Lai K, Zhang S, Lu JH, Tian R, Tan CSH
Nature communications 2023 Nov 24;14(1):7697

Characterization of huntingtin interactomes and their dynamic responses in living cells by proximity proteomics.

Xu H, Bensalel J, Raju S, Capobianco E, Lu ML, Wei J
Journal of neurochemistry 2023 Feb;164(4):512-528

ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.

Cui L, Lu Y, Zheng J, Guo B, Zhao X
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335

The myosin II inhibitor, blebbistatin, ameliorates pulmonary endothelial barrier dysfunction in acute lung injury induced by LPS via NMMHC IIA/Wnt5a/β-catenin pathway.

Zhang J, Pan Z, Zhou J, Zhang L, Tang J, Gong S, Li F, Yu B, Zhang Y, Kou J
Toxicology and applied pharmacology 2022 Sep 1;450:116132

Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-β-catenin-STAT3 signaling.

Hu S, Ren S, Cai Y, Liu J, Han Y, Zhao Y, Yang J, Zhou X, Wang X
Cell death and differentiation 2022 Mar;29(3):642-656

SRSF3 facilitates replication of influenza A virus via binding and promoting the transport of viral mRNA.

Zhao L, Li Y, Zhao Y, Liu Q, Lu Y, Ping J
Veterinary microbiology 2022 Mar;266:109343

YiQiFuMai lyophilized injection attenuates cerebral ischemic injury with inhibition of neuronal autophagy through intervention in the NMMHC IIA-actin-ATG9A interaction.

Su L, Liu Y, Ma H, Zheng F, Daia Y, Wang T, Wang G, Li F, Zhang Y, Yu B, Gong S, Kou J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153882

A functional role of S100A4/non-muscle myosin IIA axis for pro-tumorigenic vascular functions in glioblastoma.

Inukai M, Yokoi A, Ishizuka Y, Hashimura M, Matsumoto T, Oguri Y, Nakagawa M, Ishibashi Y, Ito T, Kumabe T, Saegusa M
Cell communication and signaling : CCS 2022 Apr 7;20(1):46

Naringin Promotes Skeletal Muscle Fiber Remodeling by the AdipoR1-APPL1-AMPK Signaling Pathway.

Li P, Zhang S, Song H, Traore SS, Li J, Raubenheimer D, Cui Z, Kou G
Journal of agricultural and food chemistry 2021 Oct 13;69(40):11890-11899

Ginsenoside Rg1 ameliorates blood-brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release.

Zhai K, Duan H, Wang W, Zhao S, Khan GJ, Wang M, Zhang Y, Thakur K, Fang X, Wu C, Xiao J, Wei Z
Acta pharmaceutica Sinica. B 2021 Nov;11(11):3493-3507

HBx-upregulated MAFG-AS1 promotes cell proliferation and migration of hepatoma cells by enhancing MAFG expression and stabilizing nonmuscle myosin IIA.

Zhang F, Li Y, Gan L, Tong X, Qi D, Wang Q, Ye X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21529

Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formation.

Wang S, Li S, Li Y, Jiang Q, Li X, Wang Y, Han JD, Liu Y, Chen YG
Stem cell reports 2021 May 11;16(5):1290-1301

Immunolocalization of protease-activated receptors in endothelial cells of splenic sinuses.

Uehara K, Uehara A
Cell and tissue research 2021 Dec;386(3):605-615

In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events.

Goering JP, Wenger LW, Stetsiv M, Moedritzer M, Hall EG, Isai DG, Jack BM, Umar Z, Rickabaugh MK, Czirok A, Saadi I
Human molecular genetics 2021 Dec 17;31(1):18-31

Salvia miltiorrhiza-derived miRNAs suppress vascular remodeling through regulating OTUD7B/KLF4/NMHC IIA axis.

Yang GS, Zheng B, Qin Y, Zhou J, Yang Z, Zhang XH, Zhao HY, Yang HJ, Wen JK
Theranostics 2020;10(17):7787-7811

S100A4/Nonmuscle Myosin IIA/p53 Axis Contributes to Aggressive Features in Ovarian High-Grade Serous Carcinoma.

Hiruta A, Oguri Y, Yokoi A, Matsumoto T, Oda Y, Tomohiro M, Hashimura M, Jiang Z, Tochimoto M, Nakagawa M, Saegusa M
The American journal of pathology 2020 Nov;190(11):2304-2316

S100A4/non-muscle myosin II signaling regulates epithelial-mesenchymal transition and stemness in uterine carcinosarcoma.

Tochimoto M, Oguri Y, Hashimura M, Konno R, Matsumoto T, Yokoi A, Kodera Y, Saegusa M
Laboratory investigation; a journal of technical methods and pathology 2020 May;100(5):682-695

FNDC3B 3'-UTR shortening escapes from microRNA-mediated gene repression and promotes nasopharyngeal carcinoma progression.

Li YQ, Chen Y, Xu YF, He QM, Yang XJ, Li YQ, Hong XH, Huang SY, Tang LL, Liu N
Cancer science 2020 Jun;111(6):1991-2003

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

Chen W, Wang W, Sun X, Xie S, Xu X, Liu M, Yang C, Li M, Zhang W, Liu W, Wang L, Zhou T, Yang Y
Cell death & disease 2020 Jul 14;11(7):534

MYH9 overexpression correlates with clinicopathological parameters and poor prognosis of epithelial ovarian cancer.

Liu L, Yi J, Deng X, Yuan J, Zhou B, Lin Z, Zeng Z
Oncology letters 2019 Aug;18(2):1049-1056

SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets.

Vähätupa M, Nättinen J, Jylhä A, Aapola U, Kataja M, Kööbi P, Järvinen TAH, Uusitalo H, Uusitalo-Järvinen H
Investigative ophthalmology & visual science 2018 Jul 2;59(8):3294-3306

The actomyosin network is influenced by NMHC IIA and regulated by Crp(F46), which is involved in controlling cell migration.

Cao Y, Lei Y, Luo Y, Tan T, Du B, Zheng Y, Sun L, Liang Q
Experimental cell research 2018 Dec 15;373(1-2):119-131

Deep RNA sequencing analysis of syncytialization-related genes during BeWo cell fusion.

Zheng R, Li Y, Sun H, Lu X, Sun BF, Wang R, Cui L, Zhu C, Lin HY, Wang H
Reproduction (Cambridge, England) 2016 Oct 14;

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 11128-1-AP(MYH9 antibody) at dilution of 1:3000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using MYH9 antibody 11128-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 11128-1-AP(MYH9 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue