Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10684-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10684-1-AP, RRID:AB_2100984
- Product name
- ETV4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ETV4 antibody (Cat. #10684-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ETV4 promotes the progression of cholangiocarcinoma by regulating glycolysis via the TGF-β signaling.
hnRNPU is required for spermatogonial stem cell pool establishment in mice.
Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma.
Ki67-targeted oncolytic adenovirus expressing IL-15 improves intratumoral T cell infiltration and PD-L1 expression in glioblastoma.
CIC reduces xCT/SLC7A11 expression and glutamate release in glioma.
HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.
ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer.
ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth.
Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.
ETV4 transcriptionally activates HES1 and promotes Stat3 phosphorylation to promote malignant behaviors of colon adenocarcinoma.
The CAM Model for CIC-DUX4 Sarcoma and Its Potential Use for Precision Medicine.
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.
RHOX10 drives mouse spermatogonial stem cell establishment through a transcription factor signaling cascade.
Targeting Pan-ETS Factors Inhibits Melanoma Progression.
Capicua suppresses colorectal cancer progression via repression of ETV4 expression.
Knockdown of P3H4 inhibits proliferation and invasion of bladder cancer.
Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates.
Capicua restricts cancer stem cell-like properties in breast cancer cells.
Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.
Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5.
ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.
Liu F, Wang Q, Wang Z, Zhang S, Ni Q, Chang H
Translational oncology 2024 Sep;47:102035
Translational oncology 2024 Sep;47:102035
hnRNPU is required for spermatogonial stem cell pool establishment in mice.
Wen Y, Zhou S, Gui Y, Li Z, Yin L, Xu W, Feng S, Ma X, Gan S, Xiong M, Dong J, Cheng K, Wang X, Yuan S
Cell reports 2024 Apr 23;43(4):114113
Cell reports 2024 Apr 23;43(4):114113
Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma.
Flint AC, Mitchell DK, Angus SP, Smith AE, Bessler W, Jiang L, Mang H, Li X, Lu Q, Rodriguez B, Sandusky GE, Masters AR, Zhang C, Dang P, Koenig J, Johnson GL, Shen W, Liu J, Aggarwal A, Donoho GP, Willard MD, Bhagwat SV, Clapp DW, Rhodes SD
Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Sep 1;29(17):3438-3456
Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Sep 1;29(17):3438-3456
Ki67-targeted oncolytic adenovirus expressing IL-15 improves intratumoral T cell infiltration and PD-L1 expression in glioblastoma.
Zhang Q, Zhang J, Tian Y, Wang J, Jin G, Liu F
Virology 2023 Oct;587:109885
Virology 2023 Oct;587:109885
CIC reduces xCT/SLC7A11 expression and glutamate release in glioma.
Park JW, Kilic O, Deo M, Jimenez-Cowell K, Demirdizen E, Kim H, Turcan Ş
Acta neuropathologica communications 2023 Jan 16;11(1):13
Acta neuropathologica communications 2023 Jan 16;11(1):13
HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.
Liu B, Zhang J, Meng X, Xie SM, Liu F, Chen H, Yao D, Li M, Guo M, Shen H, Zhang X, Xing L
Oncogene 2023 Apr;42(15):1181-1195
Oncogene 2023 Apr;42(15):1181-1195
ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer.
Li D, Zhan Y, Wang N, Tang F, Lee CJ, Bayshtok G, Moore AR, Wong EWP, Pachai MR, Xie Y, Sher J, Zhao JL, Khudoynazarova M, Gopalan A, Chan J, Khurana E, Shepherd P, Navone NM, Chi P, Chen Y
Science advances 2023 Apr 5;9(14):eadc9446
Science advances 2023 Apr 5;9(14):eadc9446
ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth.
Park J, Park GY, Lee J, Park J, Kim S, Kim E, Park SY, Yoon JH, Lee Y
Frontiers in molecular biosciences 2022;9:1030725
Frontiers in molecular biosciences 2022;9:1030725
Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.
Yang G, Lu S, Jiang J, Weng J, Zeng X
International journal of molecular sciences 2022 May 27;23(11)
International journal of molecular sciences 2022 May 27;23(11)
ETV4 transcriptionally activates HES1 and promotes Stat3 phosphorylation to promote malignant behaviors of colon adenocarcinoma.
Yao D, Bao Z, Qian X, Yang Y, Mao Z
Cell biology international 2021 Oct;45(10):2129-2139
Cell biology international 2021 Oct;45(10):2129-2139
The CAM Model for CIC-DUX4 Sarcoma and Its Potential Use for Precision Medicine.
Komatsu A, Matsumoto K, Yoshimatsu Y, Sin Y, Kubota A, Saito T, Mizumoto A, Ohashi S, Muto M, Noguchi R, Kondo T, Tamanoi F
Cells 2021 Oct 1;10(10)
Cells 2021 Oct 1;10(10)
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.
Cho E, Lou HJ, Kuruvilla L, Calderwood DA, Turk BE
Cell reports 2021 Mar 30;34(13):108928
Cell reports 2021 Mar 30;34(13):108928
RHOX10 drives mouse spermatogonial stem cell establishment through a transcription factor signaling cascade.
Tan K, Song HW, Wilkinson MF
Cell reports 2021 Jul 20;36(3):109423
Cell reports 2021 Jul 20;36(3):109423
Targeting Pan-ETS Factors Inhibits Melanoma Progression.
Huang L, Zhai Y, La J, Lui JW, Moore SPG, Little EC, Xiao S, Haresi AJ, Brem C, Bhawan J, Lang D
Cancer research 2021 Apr 15;81(8):2071-2085
Cancer research 2021 Apr 15;81(8):2071-2085
Capicua suppresses colorectal cancer progression via repression of ETV4 expression.
Lee JS, Kim E, Lee J, Kim D, Kim H, Kim CJ, Kim S, Jeong D, Lee Y
Cancer cell international 2020;20:42
Cancer cell international 2020;20:42
Knockdown of P3H4 inhibits proliferation and invasion of bladder cancer.
Hao L, Pang K, Pang H, Zhang J, Zhang Z, He H, Zhou R, Shi Z, Han C
Aging 2020 Feb 4;12(3):2156-2168
Aging 2020 Feb 4;12(3):2156-2168
Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates.
Ouyang W, Guo P, Takeda K, Fu Q, Fang H, Frucht DM
Proceedings of the National Academy of Sciences of the United States of America 2020 Feb 25;117(8):4078-4087
Proceedings of the National Academy of Sciences of the United States of America 2020 Feb 25;117(8):4078-4087
Capicua restricts cancer stem cell-like properties in breast cancer cells.
Yoe J, Kim D, Kim S, Lee Y
Oncogene 2020 Apr;39(17):3489-3506
Oncogene 2020 Apr;39(17):3489-3506
Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, Zoghbi HY, Tanzi RE
Cell 2019 Aug 22;178(5):1159-1175.e17
Cell 2019 Aug 22;178(5):1159-1175.e17
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.
Menon R, Otto EA, Kokoruda A, Zhou J, Zhang Z, Yoon E, Chen YC, Troyanskaya O, Spence JR, Kretzler M, Cebrián C
Development (Cambridge, England) 2018 Aug 30;145(16)
Development (Cambridge, England) 2018 Aug 30;145(16)
Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5.
Park S, Lee S, Lee CG, Park GY, Hong H, Lee JS, Kim YM, Lee SB, Hwang D, Choi YS, Fryer JD, Im SH, Lee SW, Lee Y
Nature communications 2017 Jul 12;8:16037
Nature communications 2017 Jul 12;8:16037
ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.
Lee Y, Fryer JD, Kang H, Crespo-Barreto J, Bowman AB, Gao Y, Kahle JJ, Hong JS, Kheradmand F, Orr HT, Finegold MJ, Zoghbi HY
Developmental cell 2011 Oct 18;21(4):746-57
Developmental cell 2011 Oct 18;21(4):746-57
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 10684-1-AP(ETV4 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ETV4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ETV4. This antibody recognizes human,mouse,rat antigen. The ETV4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.