10684-1-AP

antibody from Proteintech Group

Targeting: ETV4 E1A-F, E1AF, PEA3

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

10684-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10684-1-AP, RRID:AB_2100984

Product name

ETV4 antibody

Antibody type

Polyclonal

Description

KD/KO validated ETV4 antibody (Cat. #10684-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Fgf8/18 antagonizes Shh expression in lingual ventral-dorsal patterning.

Yang S, Xue J, Liu H, Zhou N, Feng H, Li N, Liu B, Zhu L, Xiao J, Liu C
Frontiers in cell and developmental biology 2026;14:1724475

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ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment.

Fu D, Zhang M, Cai M, Wang M, Huang Z, Lin Z, Liu Y, Qian W, Chen G, Liang Y, Wei D, Xie J, Yan P, Qu Y, Wei Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(26):e16557

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Aumolertinib combined with targeting ETV4 in the treatment of non-small cell lung cancer.

Lu Y, Tang D, Zhang H, Yang Z, Wang J, Gao W
Journal of thoracic disease 2026 Feb 28;18(2):125

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METTL3 inhibition alleviates neuroinflammation and apoptosis by reducing ETV4 m6A modification.

He D, Jiang X, Guo G, Ma J, Chen J, Zhang Y, Zhuang J, Xie P, Zhang Z
Frontiers in immunology 2025;16:1717319

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Comprehensive analysis of the functional and immunological significance of ETV4 in pan-cancer and its validation in digestive tumors.

Huang L, Li X, Huang S, Jiang Q, Jiang C, He W, Cai Y, Guo G
Frontiers in immunology 2025;16:1595850

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Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.

Zhang J, Wang Y, Cao S, Xie SM, Liu B, Li Y, Hou Y, Meng X, Ruan M, Bu D, Kang J, Li R, Lou L, Wang J, Xing L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e09307

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Efficacy of Minnelide in a Next-Generation Dual-Recombinase Regulated Genetically Engineered Mouse Model of CIC::DUX4 Sarcoma.

Browne MR, Silver AV, Banerjee R, Aquino B, Oristian KM, Himes JE, Hendrickson PG, Kirsch DG
bioRxiv : the preprint server for biology 2025 Nov 8;

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Identification and validation of SUN modification-related anti-PD-1 immunotherapy-resistance signatures to predict prognosis and immune microenvironment status in glioblastoma.

Zhang H, Gao M, Gao Z, Yao L, Sun H, Wang H, Zhang R, Zhan S
BMC cancer 2025 Nov 29;26(1):7

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Proteogenomic characterization of molecular and cellular targets for treatment-resistant subtypes in locally advanced cervical cancers.

Hyeon DY, Nam D, Shin HJ, Jeong J, Jung E, Cho SY, Shin DH, Ku JL, Baek HJ, Yoo CW, Hong EK, Lim MC, Lee SJ, Bae YK, Kim JK, Bae J, Choi W, Kim SJ, Back S, Kang C, Madar IH, Kim H, Kim S, Kim DK, Kang J, Park GW, Park KS, Shin Y, Kim SS, Jung K, Hwang D, Lee SW, Kim JY
Molecular cancer 2025 Mar 14;24(1):77

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ETV4 promotes the growth, metastasis, glycolysis, and oxaliplatin resistance of colorectal cancer by transcription activation-mediated SLC38A5 upregulation.

Huang Y, He J, Chen N, Du X, Peng J
Pathology, research and practice 2025 Jul;271:156033

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METTL14-mediated m6A modification of ETV4 inhibits tumor development in colorectal cancer.

Liao X, Hu T
Mutation research 2025 Jul-Dec;831:111910

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Cervical vertebrae fusion in elbow knee synostosis (Eks)-mutant mice with fibroblast growth factor 9 N143T mutation.

Djameh G, Harada M, Akita K
Congenital anomalies 2025 Jan-Dec;65(1):e70016

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Identification of ETV4 as a prognostic biomarker and correlates with immune cell infiltration in head and neck squamous cell carcinoma.

Tang Y, Xie W, Hu T, Huang C, Yin W, Wei S, Lai F, Tang L
Scientific reports 2025 Feb 27;15(1):7044

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The repressor Capicua is a barrier to lung tumor development driven by Kras/Trp53 mutations.

Ballesteros-González I, Hernández-Navas I, Brehey O, Lechuga CG, Salmón M, Scotece M, Velasco-Vicente R, Flores-Gómez AA, Cebriá A, Simón-Carrasco L, Jiménez G, Musteanu M, Guerra C, Domínguez O, Caleiras E, Blanco-Aparicio C, Pons T, Ferrer I, Paz-Ares L, Torres-Ruiz R, Rodríguez-Perales S, Barbacid M, Drosten M
EMBO molecular medicine 2025 Dec;17(12):3377-3406

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ETV4 promotes the progression of cholangiocarcinoma by regulating glycolysis via the TGF-β signaling.

Liu F, Wang Q, Wang Z, Zhang S, Ni Q, Chang H
Translational oncology 2024 Sep;47:102035

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Case of a CIC::DUX4 fusion gene in a vascular neoplasm extends the spectrum of CIC-rearranged sarcomas.

Jeck WR, Rapisardo S, Anderson BA, Hendrickson P, Jour G, Riedel RF, Brigman BE, Al-Rohil RN
Journal of cutaneous pathology 2024 Nov;51(11):840-846

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α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway.

He R, Wei Y, Peng Z, Yang J, Zhou Z, Li A, Wu Y, Wang M, Li X, Zhao D, Liu Z, Dong H, Leng X
Cellular & molecular biology letters 2024 Jun 14;29(1):88

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The capicua-ataxin-1-like complex regulates Notch-driven marginal zone B cell development and sepsis progression.

Park JS, Kang M, Kim HB, Hong H, Lee J, Song Y, Hur Y, Kim S, Kim TK, Lee Y
Nature communications 2024 Dec 4;15(1):10579

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hnRNPU is required for spermatogonial stem cell pool establishment in mice.

Wen Y, Zhou S, Gui Y, Li Z, Yin L, Xu W, Feng S, Ma X, Gan S, Xiong M, Dong J, Cheng K, Wang X, Yuan S
Cell reports 2024 Apr 23;43(4):114113

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Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma.

Flint AC, Mitchell DK, Angus SP, Smith AE, Bessler W, Jiang L, Mang H, Li X, Lu Q, Rodriguez B, Sandusky GE, Masters AR, Zhang C, Dang P, Koenig J, Johnson GL, Shen W, Liu J, Aggarwal A, Donoho GP, Willard MD, Bhagwat SV, Clapp DW, Rhodes SD
Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Sep 1;29(17):3438-3456

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Ki67-targeted oncolytic adenovirus expressing IL-15 improves intratumoral T cell infiltration and PD-L1 expression in glioblastoma.

Zhang Q, Zhang J, Tian Y, Wang J, Jin G, Liu F
Virology 2023 Oct;587:109885

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CIC reduces xCT/SLC7A11 expression and glutamate release in glioma.

Park JW, Kilic O, Deo M, Jimenez-Cowell K, Demirdizen E, Kim H, Turcan Ş
Acta neuropathologica communications 2023 Jan 16;11(1):13

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HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.

Liu B, Zhang J, Meng X, Xie SM, Liu F, Chen H, Yao D, Li M, Guo M, Shen H, Zhang X, Xing L
Oncogene 2023 Apr;42(15):1181-1195

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ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer.

Li D, Zhan Y, Wang N, Tang F, Lee CJ, Bayshtok G, Moore AR, Wong EWP, Pachai MR, Xie Y, Sher J, Zhao JL, Khudoynazarova M, Gopalan A, Chan J, Khurana E, Shepherd P, Navone NM, Chi P, Chen Y
Science advances 2023 Apr 5;9(14):eadc9446

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ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth.

Park J, Park GY, Lee J, Park J, Kim S, Kim E, Park SY, Yoon JH, Lee Y
Frontiers in molecular biosciences 2022;9:1030725

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Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.

Yang G, Lu S, Jiang J, Weng J, Zeng X
International journal of molecular sciences 2022 May 27;23(11)

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ETV4 transcriptionally activates HES1 and promotes Stat3 phosphorylation to promote malignant behaviors of colon adenocarcinoma.

Yao D, Bao Z, Qian X, Yang Y, Mao Z
Cell biology international 2021 Oct;45(10):2129-2139

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The CAM Model for CIC-DUX4 Sarcoma and Its Potential Use for Precision Medicine.

Komatsu A, Matsumoto K, Yoshimatsu Y, Sin Y, Kubota A, Saito T, Mizumoto A, Ohashi S, Muto M, Noguchi R, Kondo T, Tamanoi F
Cells 2021 Oct 1;10(10)

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PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.

Cho E, Lou HJ, Kuruvilla L, Calderwood DA, Turk BE
Cell reports 2021 Mar 30;34(13):108928

---

RHOX10 drives mouse spermatogonial stem cell establishment through a transcription factor signaling cascade.

Tan K, Song HW, Wilkinson MF
Cell reports 2021 Jul 20;36(3):109423

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Targeting Pan-ETS Factors Inhibits Melanoma Progression.

Huang L, Zhai Y, La J, Lui JW, Moore SPG, Little EC, Xiao S, Haresi AJ, Brem C, Bhawan J, Lang D
Cancer research 2021 Apr 15;81(8):2071-2085

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Capicua suppresses colorectal cancer progression via repression of ETV4 expression.

Lee JS, Kim E, Lee J, Kim D, Kim H, Kim CJ, Kim S, Jeong D, Lee Y
Cancer cell international 2020;20:42

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Knockdown of P3H4 inhibits proliferation and invasion of bladder cancer.

Hao L, Pang K, Pang H, Zhang J, Zhang Z, He H, Zhou R, Shi Z, Han C
Aging 2020 Feb 4;12(3):2156-2168

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Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates.

Ouyang W, Guo P, Takeda K, Fu Q, Fang H, Frucht DM
Proceedings of the National Academy of Sciences of the United States of America 2020 Feb 25;117(8):4078-4087

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Capicua restricts cancer stem cell-like properties in breast cancer cells.

Yoe J, Kim D, Kim S, Lee Y
Oncogene 2020 Apr;39(17):3489-3506

---

Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.

Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, Zoghbi HY, Tanzi RE
Cell 2019 Aug 22;178(5):1159-1175.e17

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Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.

Menon R, Otto EA, Kokoruda A, Zhou J, Zhang Z, Yoon E, Chen YC, Troyanskaya O, Spence JR, Kretzler M, Cebrián C
Development (Cambridge, England) 2018 Aug 30;145(16)

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Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5.

Park S, Lee S, Lee CG, Park GY, Hong H, Lee JS, Kim YM, Lee SB, Hwang D, Choi YS, Fryer JD, Im SH, Lee SW, Lee Y
Nature communications 2017 Jul 12;8:16037

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ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.

Lee Y, Fryer JD, Kang H, Crespo-Barreto J, Bowman AB, Gao Y, Kahle JJ, Hong JS, Kheradmand F, Orr HT, Finegold MJ, Zoghbi HY
Developmental cell 2011 Oct 18;21(4):746-57

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse heart tissue were subjected to SDS PAGE followed by western blot with 10684-1-AP(ETV4 antibody) at dilution of 1:500

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The ETV4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ETV4. This antibody recognizes human,mouse,rat antigen. The ETV4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

10684-1-AP.pdf

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