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- References [188]
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- Western blot [1]
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- Product number
- 21962-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21962-1-AP, RRID:AB_10898171
- Product name
- SP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SP1 antibody (Cat. #21962-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, monkey and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Potential Anti-Cancer Drug 6RK73 Suppresses Ovarian Cancer Growth by Inactivating the AKT1/Sp1 Induced c-Myc Signaling Pathway.
Tumor-Resident Streptococcus pneumoniae Promotes Malignant Progression and Pazopanib Resistance in Clear Cell Renal Cell Carcinoma.
NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2.
Angiotensin II-Induced Ferroptosis in Epithelial Cells Contributes to Kidney Injury via SP1-DPEP1-Mediated SLC3A2 Degradation.
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.
LAMA4, regulated by the transcription factor SP1 or the ubiquitin ligase NEDD4, mediates HUVEC dysfunction under hypoxia/reoxygenation conditions.
ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer.
SP1 recruits TET1 to mediate Kif1a demethylation and synaptic remodeling in a mouse model of chronic migraine.
Apoptotic metabolites synthesize and inherit unique de novo L2a/L2b RNAs to prevent virus infection.
A Metabolism-Driven Prognostic Model and PSMD14-SP1-GYS1 Axis Reveal Therapeutic Vulnerabilities in Melanoma.
Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression.
The positive feedback loop between SP1 and MAP2K2 significantly drives resistance to VEGFR inhibitors in clear cell renal cell carcinoma.
SIK2 activates the autophagy‒apoptosis pathway through SP1 regulation to inhibit the progression of hepatocellular carcinoma.
Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment.
Bone marrow mesenchymal stem cell-derived exosomal microRNA-335 alleviates vascular calcification by targeting SP1.
Sinomenine Suppresses Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting O-GlcNAcylation of SP1.
Deletion of EP3 prostaglandin receptor in murine macrophages aggravates diet-induced obesity by suppressing SPARC.
Nuclear localization of platelet activating factor receptor accounts for microglial phagocytosis in ischemic stroke.
Design, synthesis and antitumor activity of pentacyclic triterpenoid Asiatic acid derivatives as Sp1 inhibitors.
A Preliminary Study of the Relationship Between Zinc and the AhR Signaling Pathway During Palatal Development.
Botulinum Toxin Type A Inhibits Submandibular Secretion via the ERK/miR-124-3p/Specificity Protein 1/Claudin-1 Axis.
Doublecortin-like kinase 1, regulated by STIP1 homology and U-box containing protein 1 or Sp1 transcription factor, affects the malignant behaviors and drug sensitivity in adriamycin-resistant breast cancer cells.
Design, synthesis and antitumor activity of pentacyclic triterpenoid ursolic acid derivatives and oleanolic acid derivatives based on multi-target.
Single-cell landscape of mouse lungs exposed to intermittent hypoxia.
The SP1-SuperEnhancer-SPHK1 Axis Mediates Niraparib Resistance in TNBC.
SP1-Mediated upregulation of CLEC18B promotes the proliferation and metastasis of glioma through regulation of the Wnt/β-Catenin/EMT Pathway.
Kaempferol ameliorates BMSCs senescence in postmenopausal osteoporosis by targeting Sp1 to activate FUNDC1-mediated mitophagy.
Effects of p53 on the Regulation of Carbonic Anhydrase 8 in Human Colorectal Cancer Cells: Interaction Between p53 and Sp1.
10-Hydroxydec-2-enoic acid reduces vascular smooth muscle cell inflammation via interacting with Toll-like receptor 4.
SP1 promotes triple-negative breast cancer progression by targeting USP5.
ATR Deficiency Impairs DNA Damage Repair and Accelerates Cellular Senescence in Bovine Mammary Epithelial Cells, Leading to Lactation Dysfunction.
The elevated expression of ORF75, a KSHV lytic gene, in Kaposi sarcoma lesions is driven by a GC-rich DNA cis element in its promoter region.
Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML.
Reticulophagy promotes EMT-induced fibrosis in offspring's lung tissue after maternal exposure to carbon black nanoparticles during gestation by a m(5)C-dependent manner.
FASN promotes lipid metabolism and progression in colorectal cancer via the SP1/PLA2G4B axis.
Oleanolic acid activates the JNK-Sp1-DJ-1 axis to promote mitophagy-mediated neuroprotection in dopaminergic neurons for Parkinson's disease treatment.
MicroRNA-9-3p inhibits endothelial pyroptosis in atherosclerosis by targeting the PTEN/AKT axis.
DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers.
Apelin Alleviated Endothelial-To-Mesenchymal Transition via Increasing BKCa in Diabetic Nephropathy.
MYC promotes group 3 medulloblastoma cell proliferation and alleviates ROS-induced cell death by upregulating transketolase.
ETS1 promotes the expression of Ctsb and Mmp13 during the differentiation of septoclasts from pericytes.
MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation.
KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy.
Inhibition of SREBP-1c rescues hepatic CYP7B1 expression and bile acid synthesis in malnourished mice.
The MIR181A2HG/miR-5680/VCAN-CD44 Axis Regulates Gastric Cancer Lymph Node Metastasis by Promoting M2 Macrophage Polarization.
C1GALT1 high expression enhances the progression of glioblastoma through the EGFR-AKT/ERK cascade.
Chronic Stress-Induced and Tumor Derived SP1(+) Exosomes Polarizing IL-1β(+) Neutrophils to Increase Lung Metastasis of Breast Cancer.
Enhancing immunotherapy efficacy in colorectal cancer: targeting the FGR-AKT-SP1-DKK1 axis with DCC-2036 (Rebastinib).
ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation.
Pan-cancer drivers of metastasis.
Acetylation-enhanced Sp1 transcriptional activity suppresses Mlph expression.
Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation.
FADS1 inhibition protects retinal pigment epithelium cells from ferroptosis in age related macular degeneration.
AURKB inhibition induces rhabdomyosarcoma apoptosis and ferroptosis through NPM1/SP1/ACSL5 axis.
ChREBP-Mediated Choline Deprivation and Chemokine Secretion Shape Tumor-Associated Macrophages to Promote Immune Evasion.
Effect of miR-6767-5p on breast cancer cell phenotype and its regulatory mechanism.
Heparanase, a host gene that potently restricts retrovirus transcription.
4-Methylesculetin attenuates inflammatory pain via inhibition of Sp1-TRPV1 and inflammation related signaling pathways.
Effects of Different Light Environments with Varying Spectral Composition on the Axial Lengths and Scleral Specificity Protein 1 and Collagen Type I Expression in Juvenile Guinea Pigs.
Characterization of the molecular role that ST3GAL1 plays in porcine susceptibility to E. coli F18 infection.
HADHA promotes esophageal cancer progression by activating mTOR signaling and the SP1/MDM2 axis.
The Elevated Expression of ORF75, a Lytic KSHV Gene, in Kaposi Sarcoma Lesions is Driven by a GC-rich DNA cis Element in its Promoter Region.
Cyclopeptide Inhibitors Target the N-Terminal Tail of STING and Alleviate Autoinflammation.
Magnolol Inhibits High Fructose-Induced Podocyte Inflammation via Downregulation of TKFC/Sp1/HDAC4/Notch1 Activation.
Identification of senescence-related genes for potential therapeutic biomarkers of atrial fibrillation by bioinformatics, human histological validation, and molecular docking.
ΔNp63α promotes radioresistance in esophageal squamous cell carcinoma through the PLEC-KEAP1-NRF2 feedback loop.
Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis.
Renal denervation improves mitochondrial oxidative stress and cardiac hypertrophy through inactivating SP1/BACH1-PACS2 signaling.
Hepatocyte growth factor promotes melanoma metastasis through ubiquitin-specific peptidase 22-mediated integrins upregulation.
Integrative analysis of transcriptome, DNA methylome, and chromatin accessibility reveals candidate therapeutic targets in hypertrophic cardiomyopathy.
Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection.
Ferrostatin-1 improves neurological impairment induced by ischemia/reperfusion injury in the spinal cord through ERK1/2/SP1/GPX4.
High TPX2 expression results in poor prognosis, and Sp1 mediates the coupling of the CX3CR1/CXCL10 chemokine pathway to the PI3K/Akt pathway through targeted inhibition of TPX2 in endometrial cancer.
DNA hypomethylation of Syk induces oxidative stress and apoptosis via the PKCβ/P66shc signaling pathway in diabetic kidney disease.
Eucalyptol, limonene and pinene enteric capsules attenuate airway inflammation and obstruction in lipopolysaccharide-induced chronic bronchitis rat model via TLR4 signaling inhibition.
GITR exacerbates lysophosphatidylcholine-induced macrophage pyroptosis in sepsis via posttranslational regulation of NLRP3.
SMYD5 is a regulator of the mild hypothermia response.
HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis.
Neuron Derived Cold-Inducible RNA-Binding Protein Promotes NETs Formation to Exacerbate Brain Endothelial Barrier Disruption after Ischemic Stroke.
Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma.
Dysregulation of Glucocorticoid Receptor Homeostasis and Glucocorticoid-Associated Genes in Umbilical Cord Endothelial Cells of Diet-Induced Obese Pregnant Sheep.
Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent models.
Jia Wei Qingxin Lotus Seed Drink ameliorates epithelial mesenchymal transition injury in diabetic kidney disease via inhibition of JMJD1C/SP1/ZEB1 signaling pathway.
Eukaryotic translation initiation factor 6-mediated ribosome biogenesis promotes synovial aggression and inflammation by increasing the translation of SP1 in rheumatoid arthritis.
Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke.
Extracellular vesicles miR-31-5p promotes pancreatic cancer chemoresistance via regulating LATS2-Hippo pathway and promoting SPARC secretion from pancreatic stellate cells.
The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-β catenin-p300 Interactions in Hepatocellular Carcinoma.
OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression.
ZDHHC9-mediated Bip/GRP78 S-palmitoylation inhibits unfolded protein response and promotes bladder cancer progression.
SMYD5 is a regulator of the mild hypothermia response.
Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis.
PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen Receptor-Negative Breast Cancer Cell.
Canagliflozin protects against hyperglycemia-induced cerebrovascular injury by preventing blood-brain barrier (BBB) disruption via AMPK/Sp1/adenosine A2A receptor.
Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8(+) T cells.
Sp1 Regulates the M1 Polarization of Microglia Through the HuR/NF-κB Axis after Spinal Cord Injury.
hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1-mediated THBS1 transcription.
Sichen Formula Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Blocking the TLR4 Signaling Pathways.
Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer.
MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease.
Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.
Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation.
Xuelian injection ameliorates complete Freund's adjuvant-induced acute arthritis in rats via inhibiting TLR4 signaling.
Elevated high-mannose N-glycans hamper endometrial decidualization.
SP1 transcriptionally regulates UBE2N expression to promote lung adenocarcinoma progression.
Sp1 Upregulation Bolsters the Radioresistance of Glioblastoma Cells by Promoting Double Strand Breaks Repair.
Downregulation of miR‑7 and miR‑153 is involved in Helicobacter pylori CagA induced gastric carcinogenesis and progression.
The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy.
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes.
JWA inhibits nicotine-induced lung cancer stemness and progression through CHRNA5/AKT-mediated JWA/SP1/CD44 axis.
Association analysis of DNA methylation and the tissue/developmental expression of the FUT3 gene in Meishan pigs.
Sp1 Controls the Basal Level of Interleukin-34 Transcription.
DNMT1-mediated lncRNA IFFD controls the follicular development via targeting GLI1 by sponging miR-370.
Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage.
LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis.
SP1-Induced Upregulation of LncRNA AFAP1-AS1 Promotes Tumor Progression in Triple-Negative Breast Cancer by Regulating mTOR Pathway.
Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.
JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice.
Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory activity on the transcription of CDH1 to promote the progression of prostate cancer.
Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis.
Proteomic analysis reveals that ACSL4 activation during reflux esophagitis contributes to ferroptosis-mediated esophageal mucosal damage.
SP1/miR-92a-1-5p/SOCS5: A novel regulatory axis in feline panleukopenia virus replication.
Macrophage-derived exosomal miR-4532 promotes endothelial cells injury by targeting SP1 and NF-κB P65 signalling activation.
Analysis of RIOK2 Functions in Mediating the Toxic Effects of Deoxynivalenol in Porcine Intestinal Epithelial Cells.
NLRP3 Inflammasome Activation Enhances ADK Expression to Accelerate Epilepsy in Mice.
O-GlcNAc modification mediates aquaporin 3 to coordinate endometrial cell glycolysis and affects embryo implantation.
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
Differential expression of placental 11β-HSD2 induced by high maternal glucocorticoid exposure mediates sex differences in placental and fetal development.
High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein.
Intronic miR-140-5p contributes to beta-cypermethrin-mediated testosterone decline.
FBXL6 depletion restrains clear cell renal cell carcinoma progression.
Sp1 Inhibits PGC-1α via HDAC2-Catalyzed Histone Deacetylation in Chronic Constriction Injury-Induced Neuropathic Pain.
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice.
Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis.
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland.
Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling.
KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.
Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
Long non-coding RNA SNHG1 promotes fibroblast-to-myofibroblast transition during the development of pulmonary fibrosis induced by silica particles exposure.
The function of BAP18 on modulation of androgen receptor action in luteinized granulosa cells from normal weight women with and without PCOS.
Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer.
FHL1 promotes glioblastoma aggressiveness through regulating EGFR expression.
PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism.
Abnormal nitration and S-sulfhydration modification of Sp1-CSE-H(2)S pathway trap the progress of hyperhomocysteinemia into a vicious cycle.
Triptolide impairs glycolysis by suppressing GATA4/Sp1/PFKP signaling axis in mouse Sertoli cells.
SP1/AKT/FOXO3 Signaling Is Involved in miR-362-3p-Mediated Inhibition of Cell-Cycle Pathway and EMT Progression in Renal Cell Carcinoma.
High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression.
Blocking circ_0000520 Suppressed Breast Cancer Cell Growth, Migration and Invasion Partially via miR-1296/SP1 Axis Both in vitro and in vivo.
The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells.
JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin αvβ3 signaling.
Porcine Reproductive and Respiratory Syndrome Virus Structural Protein GP3 Regulates Claudin 4 To Facilitate the Early Stages of Infection.
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss.
miR-142-5p/DAX1-dependent regulation of P450c17 contributes to triclosan-mediated testosterone suppression.
JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis.
The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis.
RETRACTED: METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing.
MiRNA-130a-3p inhibits cell proliferation, migration, and TMZ resistance in glioblastoma by targeting Sp1.
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells.
The mechanism of SP1/p300 complex promotes proliferation of multiple myeloma cells through regulating IQGAP1 transcription.
HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I.
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Involvement of multiple transcription factors in regulation of IL-β-induced MCP-1 expression in alveolar type II epithelial cells.
Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.
MIR-300 in the imprinted DLK1-DIO3 domain suppresses the migration of bladder cancer by regulating the SP1/MMP9 pathway.
Sp1 Suppresses miR-3178 to Promote the Metastasis Invasion Cascade via Upregulation of TRIOBP.
2-(2-nitrobenzylidene) indolin-3-one compound inhibits transmembrane prostate androgen-induced protein (TMEPAI) expression and cancer cell proliferation.
Long non-coding RNA FTH1P3 regulated metastasis and invasion of esophageal squamous cell carcinoma through SP1/NF-kB pathway.
Sp1-regulated transcription of RasGRP1 promotes hepatocellular carcinoma (HCC) proliferation.
Fatty acid elongase7 is regulated via SP1 and is involved in lipid accumulation in bovine mammary epithelial cells.
Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma.
Improved Sp1 and Betaine Homocysteine-S-Methyltransferase Expression and Homocysteine Clearance Are Involved in the Effects of Zinc on Oxidative Stress in High-Fat-Diet-Pretreated Mice.
Glucocorticoids regulate MiR-29c levels in vascular smooth muscle cells through transcriptional and epigenetic mechanisms.
ICAM-1 regulates macrophage polarization by suppressing MCP-1 expression via miR-124 upregulation.
A G-quadruplex structure at the 5' end of the H19 coding region regulates H19 transcription.
Hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance and Replication through Two Distinct Mechanisms.
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Hepatitis B virus X protein up-regulates C4b-binding protein α through activating transcription factor Sp1 in protection of hepatoma cells from complement attack.
Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.
MiR-24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1.
Mechanisms underlying aberrant expression of miR-29c in uterine leiomyoma.
The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells.
SP1-mediated microRNA-520d-5p suppresses tumor growth and metastasis in colorectal cancer by targeting CTHRC1.
Mature miR-183, negatively regulated by transcription factor GATA3, promotes 3T3-L1 adipogenesis through inhibition of the canonical Wnt/β-catenin signaling pathway by targeting LRP6.
UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.
Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth.
Kuang S, Feng W, He S, Meng W, Yang C, Ning Y
Journal of Cancer 2026;17(2):245-256
Journal of Cancer 2026;17(2):245-256
Tumor-Resident Streptococcus pneumoniae Promotes Malignant Progression and Pazopanib Resistance in Clear Cell Renal Cell Carcinoma.
Wang J, Nan Y, Liu Q, Ding T, Liu D, Duo L, Zhao J, Gao S, Zhang Y, Dai Z, Yan S, Zhang W, Li Z, Liu W, Han B, Zhao Y, Yu Y, Zhao E, Li X, You B
Cancer research 2026 May 4;86(9):2237-2252
Cancer research 2026 May 4;86(9):2237-2252
NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2.
Zhang L, Zhang Y, Wen D, Guo S, Qi X, Wang H, Sun Y, Yang G, Wang Y, Xue S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e05240
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e05240
Angiotensin II-Induced Ferroptosis in Epithelial Cells Contributes to Kidney Injury via SP1-DPEP1-Mediated SLC3A2 Degradation.
Tian Y, Yang G, Zhang Q, Dong C, Li Y, Lv S, Li S, Zhang H, Jiang X, Xin Y
Diabetes 2026 Mar 1;75(3):548-562
Diabetes 2026 Mar 1;75(3):548-562
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.
Zhang N, Zhao R, Zhong X, Dong Q, Liu Y, Yu K, Han L, Meng F, Wu J, Chen Q, Li X, Chen Q, Zhang K, Huang H, Zhang J, Wu S, Ren Y, Wang W, Liu Y
Nature communications 2026 Jan 8;17(1):1406
Nature communications 2026 Jan 8;17(1):1406
LAMA4, regulated by the transcription factor SP1 or the ubiquitin ligase NEDD4, mediates HUVEC dysfunction under hypoxia/reoxygenation conditions.
Zhang W, Lu D
Cytotechnology 2026 Feb;78(1):4
Cytotechnology 2026 Feb;78(1):4
ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer.
Tang XC, Chen ZJ, Chen CY, Qiu J, Huang JT, Tan RC, Li WY, Chen H, Yang ZL
World journal of gastroenterology 2026 Feb 7;32(5):115301
World journal of gastroenterology 2026 Feb 7;32(5):115301
SP1 recruits TET1 to mediate Kif1a demethylation and synaptic remodeling in a mouse model of chronic migraine.
Jiang W, Yu P, Liang GH, Tian WB, Li YF, Cai MT, Zhang LX, Yang Y, Dong M
The journal of headache and pain 2026 Feb 21;27(1)
The journal of headache and pain 2026 Feb 21;27(1)
Apoptotic metabolites synthesize and inherit unique de novo L2a/L2b RNAs to prevent virus infection.
Li P, Lan Y, Yan X, Cao Z, Ji J, Deng M, He D, Huang R, Qu Y, Wu Y, Zhang X, Cui J, Luo G, Bao X, Shi S
Bioactive materials 2026 Apr;58:236-251
Bioactive materials 2026 Apr;58:236-251
A Metabolism-Driven Prognostic Model and PSMD14-SP1-GYS1 Axis Reveal Therapeutic Vulnerabilities in Melanoma.
Xie J, Zhao S, Wu D, Ma C, Yan W, Zhang P, Lu Q, Wan Z, Tang Q, Li L, Wang M, He Y
The Journal of investigative dermatology 2026 Apr;146(4):1074-1088.e5
The Journal of investigative dermatology 2026 Apr;146(4):1074-1088.e5
Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression.
Peng S, Lin W, Li Z, Zhuang R, Peng S, Li B, Chen B, Luo Y, Ou Y, Zhuang W, Du T, Li K, Huang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e08588
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e08588
The positive feedback loop between SP1 and MAP2K2 significantly drives resistance to VEGFR inhibitors in clear cell renal cell carcinoma.
Xia Z, Yang Z, Dong Y, Hao X, Wang K, Xia W, Ren L, Li T, Xu M, Zhu G, Zhang C
International journal of biological sciences 2025;21(2):860-873
International journal of biological sciences 2025;21(2):860-873
SIK2 activates the autophagy‒apoptosis pathway through SP1 regulation to inhibit the progression of hepatocellular carcinoma.
Fan S, Zhang Y, Ma P, Hou H, Niu R, Wang Z, Zhang J, Xia Y, Pan Y
Frontiers in pharmacology 2025;16:1635953
Frontiers in pharmacology 2025;16:1635953
Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment.
Wei Z, Mu H, Qiu F, Zhao M, Zhang X, Li W, Jia H, Wang R
Frontiers in physiology 2025;16:1520246
Frontiers in physiology 2025;16:1520246
Bone marrow mesenchymal stem cell-derived exosomal microRNA-335 alleviates vascular calcification by targeting SP1.
Li Y, Chen C, Kong J, Huang J, Liu L, Liu C, Dai B, Huang M
Frontiers in cardiovascular medicine 2025;12:1572045
Frontiers in cardiovascular medicine 2025;12:1572045
Sinomenine Suppresses Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting O-GlcNAcylation of SP1.
Liu L, Peng J, Chen H, Chen J, Xu W, Han Y
Clinical and experimental pharmacology & physiology 2025 Sep;52(9):e70057
Clinical and experimental pharmacology & physiology 2025 Sep;52(9):e70057
Deletion of EP3 prostaglandin receptor in murine macrophages aggravates diet-induced obesity by suppressing SPARC.
Shang W, Li Y, Wang L, Liu J, Ren H, Liu Q, Guo S, Wang Y, Ma Y, You T, Shen Y, Zhou Y, Tian D, Yu Y
The EMBO journal 2025 Sep;44(18):4962-4983
The EMBO journal 2025 Sep;44(18):4962-4983
Nuclear localization of platelet activating factor receptor accounts for microglial phagocytosis in ischemic stroke.
Zhang XY, Xu H, Ren XW, Li QX, Hong C, Chen YF, Yang J, Ji J, Guo RB, Sun XL
Neurobiology of disease 2025 Sep;213:107020
Neurobiology of disease 2025 Sep;213:107020
Design, synthesis and antitumor activity of pentacyclic triterpenoid Asiatic acid derivatives as Sp1 inhibitors.
Lu XH, Yu XR, Zhang LF, Han YT, Wu H, Wang Z, Meng YQ
Bioorganic & medicinal chemistry letters 2025 Sep 8;130:130398
Bioorganic & medicinal chemistry letters 2025 Sep 8;130:130398
A Preliminary Study of the Relationship Between Zinc and the AhR Signaling Pathway During Palatal Development.
Liang S, Zhai Y, Chen Z, Yang J, Shu X, Luo J, Wang N, Wang F, Song Q
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2025 Sep 8;:10556656251375952
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2025 Sep 8;:10556656251375952
Botulinum Toxin Type A Inhibits Submandibular Secretion via the ERK/miR-124-3p/Specificity Protein 1/Claudin-1 Axis.
Mao QY, Huang Y, Chen Z, Shan XF, Xie S, Wu LL, Xiang RL, Cai ZG
Cells 2025 Sep 2;14(17)
Cells 2025 Sep 2;14(17)
Doublecortin-like kinase 1, regulated by STIP1 homology and U-box containing protein 1 or Sp1 transcription factor, affects the malignant behaviors and drug sensitivity in adriamycin-resistant breast cancer cells.
Cheng L, Qi P, Guo W, Gao S
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):13995-14008
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):13995-14008
Design, synthesis and antitumor activity of pentacyclic triterpenoid ursolic acid derivatives and oleanolic acid derivatives based on multi-target.
Ma JJ, Zhang LF, Xu DP, Wang Z, Meng YQ
Journal of Asian natural products research 2025 Oct;27(10):1429-1446
Journal of Asian natural products research 2025 Oct;27(10):1429-1446
Single-cell landscape of mouse lungs exposed to intermittent hypoxia.
Zheng P, Wang L, Zhu X, Mao Z, Zhang F, Zi G, Chen L, Liu H, Zhou L, Liu W
Respiratory research 2025 Oct 28;26(1):300
Respiratory research 2025 Oct 28;26(1):300
The SP1-SuperEnhancer-SPHK1 Axis Mediates Niraparib Resistance in TNBC.
Yuan YX, Chen RJ, Tu GH, Li CQ, Xu LL, Lu YL, Wu LX
Pharmaceuticals (Basel, Switzerland) 2025 Oct 27;18(11)
Pharmaceuticals (Basel, Switzerland) 2025 Oct 27;18(11)
SP1-Mediated upregulation of CLEC18B promotes the proliferation and metastasis of glioma through regulation of the Wnt/β-Catenin/EMT Pathway.
Liu H, Zhu B, Cui Y, Liu W, Xu Q, Lu X, Tan Z, Tian Y, Xu W
Translational oncology 2025 Nov;61:102515
Translational oncology 2025 Nov;61:102515
Kaempferol ameliorates BMSCs senescence in postmenopausal osteoporosis by targeting Sp1 to activate FUNDC1-mediated mitophagy.
Wang L, Qu Y, Hu Z, Lei P, Tian X, Yang X, Chen S, Li C, Wei B, Li L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157456
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157456
Effects of p53 on the Regulation of Carbonic Anhydrase 8 in Human Colorectal Cancer Cells: Interaction Between p53 and Sp1.
Yu JY, Hsieh BY, Tsai SF, Hsieh M
Cell biochemistry and function 2025 May;43(5):e70081
Cell biochemistry and function 2025 May;43(5):e70081
10-Hydroxydec-2-enoic acid reduces vascular smooth muscle cell inflammation via interacting with Toll-like receptor 4.
Jia F, Wang Y, Chen Z, Jin J, Zeng L, Zhang L, Tang H, Wang Y, Fan P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156534
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156534
SP1 promotes triple-negative breast cancer progression by targeting USP5.
Wu SY, Peng ZM, Deng FY, Xiong JY, Luo PY, Han XJ, Zhang Z
Cancer cell international 2025 May 15;25(1):177
Cancer cell international 2025 May 15;25(1):177
ATR Deficiency Impairs DNA Damage Repair and Accelerates Cellular Senescence in Bovine Mammary Epithelial Cells, Leading to Lactation Dysfunction.
Zhou Q, Geng Z, Lian S, Wang J, Wu R
Animals : an open access journal from MDPI 2025 May 14;15(10)
Animals : an open access journal from MDPI 2025 May 14;15(10)
The elevated expression of ORF75, a KSHV lytic gene, in Kaposi sarcoma lesions is driven by a GC-rich DNA cis element in its promoter region.
Nair A, Davis DA, Warner A, Karim B, Ramaswami R, Yarchoan R
PLoS pathogens 2025 Mar;21(3):e1012984
PLoS pathogens 2025 Mar;21(3):e1012984
Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML.
Zhong Y, Zhang R, Lu L, Tan H, You Y, Mao Y, Yuan Y
Cell communication and signaling : CCS 2025 Mar 8;23(1):126
Cell communication and signaling : CCS 2025 Mar 8;23(1):126
Reticulophagy promotes EMT-induced fibrosis in offspring's lung tissue after maternal exposure to carbon black nanoparticles during gestation by a m(5)C-dependent manner.
Du Z, Liu Q, Wang M, Gao Y, Li Q, Yang Y, Lu T, Bao L, Pang Y, Wang H, Niu Y, Zhang R
Journal of hazardous materials 2025 Mar 5;485:136873
Journal of hazardous materials 2025 Mar 5;485:136873
FASN promotes lipid metabolism and progression in colorectal cancer via the SP1/PLA2G4B axis.
Liu X, Lu J, Ni X, He Y, Wang J, Deng Z, Zhang G, Shi T, Chen W
Cell death discovery 2025 Mar 28;11(1):122
Cell death discovery 2025 Mar 28;11(1):122
Oleanolic acid activates the JNK-Sp1-DJ-1 axis to promote mitophagy-mediated neuroprotection in dopaminergic neurons for Parkinson's disease treatment.
Yang HB, Lee CH, Nhung NT, Hung SY
Archives of pharmacal research 2025 Jun;48(6):528-548
Archives of pharmacal research 2025 Jun;48(6):528-548
MicroRNA-9-3p inhibits endothelial pyroptosis in atherosclerosis by targeting the PTEN/AKT axis.
Wu Y, Ma Q, Meng X, Sun Q, Wang Z, Zhang W
International journal of biological macromolecules 2025 Jun;315(Pt 1):144289
International journal of biological macromolecules 2025 Jun;315(Pt 1):144289
DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers.
Doyle C, Herka K, Flynn SM, Melidis L, Dhir S, Schoenfelder S, Tannahill D, Balasubramanian S
Genome biology 2025 Jun 4;26(1):155
Genome biology 2025 Jun 4;26(1):155
Apelin Alleviated Endothelial-To-Mesenchymal Transition via Increasing BKCa in Diabetic Nephropathy.
Fan C, Liu Y, Chang J, Huang M, Gao Z, Wang H, Zheng X, Li M, Xu J, Yin J, Zeng X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70747
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70747
MYC promotes group 3 medulloblastoma cell proliferation and alleviates ROS-induced cell death by upregulating transketolase.
Wang S, Zhang D, Wang C, Liu Y
Acta neuropathologica communications 2025 Jun 28;13(1):139
Acta neuropathologica communications 2025 Jun 28;13(1):139
ETS1 promotes the expression of Ctsb and Mmp13 during the differentiation of septoclasts from pericytes.
Bando Y, Bandow K, Sakiyama K, Nagasaka A, Suzuki K, Toda-Fujii M, Owada Y, Amano O
Cell and tissue research 2025 Jul;401(1):29-42
Cell and tissue research 2025 Jul;401(1):29-42
MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation.
Wang T, Rao D, Fu C, Sun Z, Luo Y, Lu J, Jin J, Li H, Fan F, Liang H, Huang W, Xia L
Clinical and molecular hepatology 2025 Jul;31(3):1032-1057
Clinical and molecular hepatology 2025 Jul;31(3):1032-1057
KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy.
Guo J, Li N, Liu Q, Hao Z, Zhu G, Wang X, Wang H, Pan Q, Xu B, Han Y, Zhang G, Lian Y, Zhang W, Gu Y, Lin N, Zeng X, Jin Z, Lan W, Jiang J, Gao D, Dong L, Yuan H, Liang C, Qin J
Cancer cell 2025 Jul 14;43(7):1261-1278.e10
Cancer cell 2025 Jul 14;43(7):1261-1278.e10
Inhibition of SREBP-1c rescues hepatic CYP7B1 expression and bile acid synthesis in malnourished mice.
Wan X, Soni KG, Choi JM, Jung SY, Conner ME, Preidis GA
American journal of physiology. Gastrointestinal and liver physiology 2025 Jul 1;329(1):G232-G243
American journal of physiology. Gastrointestinal and liver physiology 2025 Jul 1;329(1):G232-G243
The MIR181A2HG/miR-5680/VCAN-CD44 Axis Regulates Gastric Cancer Lymph Node Metastasis by Promoting M2 Macrophage Polarization.
Zang W, Yang Y, Chen J, Mao Q, Xue W, Hu Y
Cancer medicine 2025 Jan;14(2):e70600
Cancer medicine 2025 Jan;14(2):e70600
C1GALT1 high expression enhances the progression of glioblastoma through the EGFR-AKT/ERK cascade.
Su Y, Ao X, Long Y, Zhang Z, Zhang M, Zhang Z, Wei M, Shan S, Lu S, Yu Y, Xu B
Cellular signalling 2025 Jan;125:111513
Cellular signalling 2025 Jan;125:111513
Chronic Stress-Induced and Tumor Derived SP1(+) Exosomes Polarizing IL-1β(+) Neutrophils to Increase Lung Metastasis of Breast Cancer.
Zhang L, Pan J, Wang M, Yang J, Zhu S, Li L, Hu X, Wang Z, Pang L, Li P, Jia F, Ren G, Zhang Y, Xu D, Qiu F, Huang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(4):e2310266
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(4):e2310266
Enhancing immunotherapy efficacy in colorectal cancer: targeting the FGR-AKT-SP1-DKK1 axis with DCC-2036 (Rebastinib).
Chen X, Zeng Q, Yin L, Yan B, Wu C, Feng J, Wu Y, He J, Ding W, Zhong J, Shen Y, Zu X
Cell death & disease 2025 Jan 9;16(1):8
Cell death & disease 2025 Jan 9;16(1):8
ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation.
Chang Y, He Y, Wang D, Zhang K, Zhang Y, Li Z, Zeng S, Xiao S, Pan S, Huang K
Acta neuropathologica communications 2025 Jan 27;13(1):16
Acta neuropathologica communications 2025 Jan 27;13(1):16
Pan-cancer drivers of metastasis.
Lusby R, Demirdizen E, Inayatullah M, Kundu P, Maiques O, Zhang Z, Terp MG, Sanz-Moreno V, Tiwari VK
Molecular cancer 2025 Jan 2;24(1):2
Molecular cancer 2025 Jan 2;24(1):2
Acetylation-enhanced Sp1 transcriptional activity suppresses Mlph expression.
Jo CS, Zhao H, Hwang JS
Scientific reports 2025 Jan 17;15(1):2338
Scientific reports 2025 Jan 17;15(1):2338
Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation.
Song L, Huang Y, Liu L, Chang X, Hu L, Wang G, Xu L, Zhang T, Wang Y, Xiao Y, Yang H, Ran S, Shi Q, Wang T, Shi M, Zhou Y, Guo B
Cell reports 2025 Feb 25;44(2):115246
Cell reports 2025 Feb 25;44(2):115246
FADS1 inhibition protects retinal pigment epithelium cells from ferroptosis in age related macular degeneration.
Zhang A, Wei TT, Tan X, Tan CY, Zhuang M, Xie TH, Cai J, Yao Y, Zhu L
European journal of pharmacology 2025 Feb 15;989:177227
European journal of pharmacology 2025 Feb 15;989:177227
AURKB inhibition induces rhabdomyosarcoma apoptosis and ferroptosis through NPM1/SP1/ACSL5 axis.
Chen H, Li M, Zhang Y, Song M, Que Y, Wang J, Sun F, Zhu J, Huang J, Liu J, Xu J, Lu S, Zhang Y
JCI insight 2025 Feb 10;10(3)
JCI insight 2025 Feb 10;10(3)
ChREBP-Mediated Choline Deprivation and Chemokine Secretion Shape Tumor-Associated Macrophages to Promote Immune Evasion.
Zhao J, Chen B, Deng Y, Fan L, Yin S, Yu H, Wei Y, Dai J, Qian Q, Chen Q, Ren X, Xie X, Wei W, Zhang J, Jiang C
Cancer research 2025 Dec 1;85(23):4701-4717
Cancer research 2025 Dec 1;85(23):4701-4717
Effect of miR-6767-5p on breast cancer cell phenotype and its regulatory mechanism.
Tan ZH, Ren Y, Zhou FL, Liu S
Scientific reports 2025 Aug 26;15(1):31394
Scientific reports 2025 Aug 26;15(1):31394
Heparanase, a host gene that potently restricts retrovirus transcription.
Waxman B, Salka K, Timilsina U, Umthong S, Shukla D, Stavrou S
mBio 2025 Apr 9;16(4):e0325224
mBio 2025 Apr 9;16(4):e0325224
4-Methylesculetin attenuates inflammatory pain via inhibition of Sp1-TRPV1 and inflammation related signaling pathways.
Zhao W, Chen M, Yu X, Zhong H, Hao S, Liu S, Tian Z, Dong L, Dai S, Liu H, Hao H
International immunopharmacology 2025 Apr 16;152:114379
International immunopharmacology 2025 Apr 16;152:114379
Effects of Different Light Environments with Varying Spectral Composition on the Axial Lengths and Scleral Specificity Protein 1 and Collagen Type I Expression in Juvenile Guinea Pigs.
Yuan J, Wang Y, Xu X, Yang M, Fan Y, Shi X, Sun L, Shan M, Ma L
Folia biologica 2024;70(4):219-228
Folia biologica 2024;70(4):219-228
Characterization of the molecular role that ST3GAL1 plays in porcine susceptibility to E. coli F18 infection.
Wu Z, Li M, Wu J, Jin S, Xu Y, Jin J, Wu Y
International journal of biological macromolecules 2024 Sep;276(Pt 2):133959
International journal of biological macromolecules 2024 Sep;276(Pt 2):133959
HADHA promotes esophageal cancer progression by activating mTOR signaling and the SP1/MDM2 axis.
Ding X, Shao L, Wang J, Jin Y, Chen H, Li B
Acta biochimica et biophysica Sinica 2024 Sep 26;57(3):378-388
Acta biochimica et biophysica Sinica 2024 Sep 26;57(3):378-388
The Elevated Expression of ORF75, a Lytic KSHV Gene, in Kaposi Sarcoma Lesions is Driven by a GC-rich DNA cis Element in its Promoter Region.
Nair A, Davis DA, Warner A, Karim B, Ramaswami R, Yarchoan R
bioRxiv : the preprint server for biology 2024 Sep 26;
bioRxiv : the preprint server for biology 2024 Sep 26;
Cyclopeptide Inhibitors Target the N-Terminal Tail of STING and Alleviate Autoinflammation.
Wang X, Cao A, Zheng W, Quan J
Chemistry & biodiversity 2024 Oct;21(10):e202401253
Chemistry & biodiversity 2024 Oct;21(10):e202401253
Magnolol Inhibits High Fructose-Induced Podocyte Inflammation via Downregulation of TKFC/Sp1/HDAC4/Notch1 Activation.
Zhou Z, Wang Y, Xing Y, Pan S, Wang W, Yang J, Wu W, Zhou J, Huang L, Liang Q, Zhang D, Kong L
Pharmaceuticals (Basel, Switzerland) 2024 Oct 23;17(11)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 23;17(11)
Identification of senescence-related genes for potential therapeutic biomarkers of atrial fibrillation by bioinformatics, human histological validation, and molecular docking.
Liu J, Zhou T, Bao Y, Lin C, Chen Q, Dai Y, Zhang N, Pan W, Jin Q, Lu L, Zhao Q, Ling T, Wu L
Heliyon 2024 Oct 15;10(19):e37366
Heliyon 2024 Oct 15;10(19):e37366
ΔNp63α promotes radioresistance in esophageal squamous cell carcinoma through the PLEC-KEAP1-NRF2 feedback loop.
Tao J, Mao M, Lu Y, Deng L, Yu S, Zeng X, Jia W, Wu Z, Li C, Ma R, Chen H
Cell death & disease 2024 Nov 5;15(11):793
Cell death & disease 2024 Nov 5;15(11):793
Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis.
Ninomiya Y, Matsuda S, Suzuki S, Hirata-Tsuchiya S, Ueda T, Nakashima F, Yasuda K, Shimada S, Memida T, Yoshimoto T, Yamada S, Ouhara K, Mizuno N
BMC oral health 2024 Nov 21;24(1):1422
BMC oral health 2024 Nov 21;24(1):1422
Renal denervation improves mitochondrial oxidative stress and cardiac hypertrophy through inactivating SP1/BACH1-PACS2 signaling.
Shen Z, Zhang Y, Bu G, Fang L
International immunopharmacology 2024 Nov 15;141:112778
International immunopharmacology 2024 Nov 15;141:112778
Hepatocyte growth factor promotes melanoma metastasis through ubiquitin-specific peptidase 22-mediated integrins upregulation.
Gao Q, Li N, Pan Y, Chu P, Zhou Y, Jia H, Cheng Y, Xue G, Song J, Zhang Y, Zhu H, Sun J, Zhang B, Sun Z, Fang D
Cancer letters 2024 Nov 1;604:217196
Cancer letters 2024 Nov 1;604:217196
Integrative analysis of transcriptome, DNA methylome, and chromatin accessibility reveals candidate therapeutic targets in hypertrophic cardiomyopathy.
Gao J, Liu M, Lu M, Zheng Y, Wang Y, Yang J, Xue X, Liu Y, Tang F, Wang S, Song L, Wen L, Wang J
Protein & cell 2024 Nov 1;15(11):796-817
Protein & cell 2024 Nov 1;15(11):796-817
Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection.
Wang Y, Zhao X, Li Z, Wang W, Jiang Y, Zhang H, Liu X, Ren Y, Xu X, Hu X
Communications biology 2024 May 31;7(1):669
Communications biology 2024 May 31;7(1):669
Ferrostatin-1 improves neurological impairment induced by ischemia/reperfusion injury in the spinal cord through ERK1/2/SP1/GPX4.
Liu S, Chen F, Han J, Wang L, Dong Y
Experimental neurology 2024 Mar;373:114659
Experimental neurology 2024 Mar;373:114659
High TPX2 expression results in poor prognosis, and Sp1 mediates the coupling of the CX3CR1/CXCL10 chemokine pathway to the PI3K/Akt pathway through targeted inhibition of TPX2 in endometrial cancer.
Yang M, Mao X, Li L, Yang J, Xing H, Jiang C
Cancer medicine 2024 Mar;13(5):e6958
Cancer medicine 2024 Mar;13(5):e6958
DNA hypomethylation of Syk induces oxidative stress and apoptosis via the PKCβ/P66shc signaling pathway in diabetic kidney disease.
Zhang R, Qin C, Zhang J, HonghongRen, Wang Y, Wu Y, Zhao L, Wang J, Zhang J, Liu F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 31;38(6):e23564
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 31;38(6):e23564
Eucalyptol, limonene and pinene enteric capsules attenuate airway inflammation and obstruction in lipopolysaccharide-induced chronic bronchitis rat model via TLR4 signaling inhibition.
Qiu XY, Yan LS, Kang JY, Yu Gu C, Chi-Yan Cheng B, Wang YW, Luo G, Zhang Y
International immunopharmacology 2024 Mar 10;129:111571
International immunopharmacology 2024 Mar 10;129:111571
GITR exacerbates lysophosphatidylcholine-induced macrophage pyroptosis in sepsis via posttranslational regulation of NLRP3.
Liang S, Zhou J, Cao C, Liu Y, Ming S, Liu X, Shang Y, Lao J, Peng Q, Yang J, Wu M
Cellular & molecular immunology 2024 Jul;21(7):674-688
Cellular & molecular immunology 2024 Jul;21(7):674-688
SMYD5 is a regulator of the mild hypothermia response.
Rafnsdottir S, Jang K, Halldorsdottir ST, Vinod M, Tomasdottir A, Möller K, Halldorsdottir K, Reynisdottir T, Atladottir LH, Allison KE, Ostacolo K, He J, Zhang L, Northington FJ, Magnusdottir E, Chavez-Valdez R, Anderson KJ, Bjornsson HT
bioRxiv : the preprint server for biology 2024 Jul 12;
bioRxiv : the preprint server for biology 2024 Jul 12;
HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis.
Yang K, Li J, Zhu J, Chen Y, He Y, Wang J, Shen K, Wang K, Shi T, Chen W
Cell death discovery 2024 Jan 16;10(1):33
Cell death discovery 2024 Jan 16;10(1):33
Neuron Derived Cold-Inducible RNA-Binding Protein Promotes NETs Formation to Exacerbate Brain Endothelial Barrier Disruption after Ischemic Stroke.
Li Z, Sun S, Xiao Q, Tan S, Jin H, Hu B
Aging and disease 2024 Feb 4;16(1):520-539
Aging and disease 2024 Feb 4;16(1):520-539
Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma.
Wang S, Zhu L, Li T, Lin X, Zheng Y, Xu D, Guo Y, Zhang Z, Fu Y, Wang H, Wang X, Zou T, Shen X, Zhang L, Lai N, Lu L, Qin L, Dong Q
Cell reports. Medicine 2024 Feb 20;5(2):101415
Cell reports. Medicine 2024 Feb 20;5(2):101415
Dysregulation of Glucocorticoid Receptor Homeostasis and Glucocorticoid-Associated Genes in Umbilical Cord Endothelial Cells of Diet-Induced Obese Pregnant Sheep.
Mata-Greenwood E, Chow WL, Anti NAO, Sands LD, Adeoye O, Ford SP, Nathanielsz PW
International journal of molecular sciences 2024 Feb 15;25(4)
International journal of molecular sciences 2024 Feb 15;25(4)
Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent models.
Xu C, Wang Y, Ni C, Xu M, Yin C, He Q, Ma B, Fu J, Zhao B, Chen L, Zhi T, Wei S, Cheng L, Xu H, Xiao J, Yang L, Xu Q, Kuang J, Liu B, Zhou Q, Lin X, Yao M, Ni H
EMBO reports 2024 Dec;25(12):5429-5455
EMBO reports 2024 Dec;25(12):5429-5455
Jia Wei Qingxin Lotus Seed Drink ameliorates epithelial mesenchymal transition injury in diabetic kidney disease via inhibition of JMJD1C/SP1/ZEB1 signaling pathway.
Xie J, Lin H, Jin F, Luo Y, Yang P, Song J, Yao W, Lin W, Yuan D, Zuo A, Sun J, Wang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156142
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156142
Eukaryotic translation initiation factor 6-mediated ribosome biogenesis promotes synovial aggression and inflammation by increasing the translation of SP1 in rheumatoid arthritis.
Shen C, Peng C, Zhang S, Li R, Liu S, Kuang Y, Su F, Liu Y, Liang L, Xiao Y, Xu H
International immunopharmacology 2024 Dec 5;142(Pt B):113164
International immunopharmacology 2024 Dec 5;142(Pt B):113164
Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke.
Guo H, Li Y, Wang S, Yang Y, Xu T, Zhao J, Wang J, Zuo W, Wang P, Zhao G, Wang H, Hou W, Dong H, Cai Y
Redox biology 2024 Aug;74:103234
Redox biology 2024 Aug;74:103234
Extracellular vesicles miR-31-5p promotes pancreatic cancer chemoresistance via regulating LATS2-Hippo pathway and promoting SPARC secretion from pancreatic stellate cells.
Qin C, Zhao B, Wang Y, Li Z, Li T, Zhao Y, Wang W, Zhao Y
Journal of extracellular vesicles 2024 Aug;13(8):e12488
Journal of extracellular vesicles 2024 Aug;13(8):e12488
The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-β catenin-p300 Interactions in Hepatocellular Carcinoma.
Leung YK, Lee SG, Wang J, Guruvaiah P, Rusch NJ, Ho SM, Park C, Kim K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2308539
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2308539
OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression.
Zhu W, Wu C, Liu Z, Zhao S, Huang J
Cell communication and signaling : CCS 2024 Aug 29;22(1):420
Cell communication and signaling : CCS 2024 Aug 29;22(1):420
ZDHHC9-mediated Bip/GRP78 S-palmitoylation inhibits unfolded protein response and promotes bladder cancer progression.
Li W, Liu J, Yu T, Lu F, Miao Q, Meng X, Xiao W, Yang H, Zhang X
Cancer letters 2024 Aug 28;598:217118
Cancer letters 2024 Aug 28;598:217118
SMYD5 is a regulator of the mild hypothermia response.
Rafnsdottir S, Jang K, Halldorsdottir ST, Vinod M, Tomasdottir A, Möller K, Halldorsdottir K, Reynisdottir T, Atladottir LH, Allison KE, Ostacolo K, He J, Zhang L, Northington FJ, Magnusdottir E, Chavez-Valdez R, Anderson KJ, Bjornsson HT
Cell reports 2024 Aug 27;43(8):114554
Cell reports 2024 Aug 27;43(8):114554
Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis.
Li H, Du Y, Cheng K, Chen Y, Wei L, Pei Y, Wang X, Wang L, Zhang Y, Hu X, Lu Y, Zhu X
Cell discovery 2024 Aug 27;10(1):89
Cell discovery 2024 Aug 27;10(1):89
PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen Receptor-Negative Breast Cancer Cell.
Zhang X, Wang S, Li W, Wang J, Gong Y, Chen Q, Cao S, Pang D, Gao S
Biomolecules 2024 Aug 12;14(8)
Biomolecules 2024 Aug 12;14(8)
Canagliflozin protects against hyperglycemia-induced cerebrovascular injury by preventing blood-brain barrier (BBB) disruption via AMPK/Sp1/adenosine A2A receptor.
Liu Z, Hua W, Jin S, Wang Y, Pang Y, Wang B, Zhao N, Song Y, Qi J
European journal of pharmacology 2024 Apr 5;968:176381
European journal of pharmacology 2024 Apr 5;968:176381
Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8(+) T cells.
Cao T, Zhang W, Wang Q, Wang C, Ma W, Zhang C, Ge M, Tian M, Yu J, Jiao A, Wang L, Liu M, Wang P, Guo Z, Zhou Y, Chen S, Yin W, Yi J, Guo H, Han H, Zhang B, Wu K, Fan D, Wang X, Nie Y, Lu Y, Zhao X
Cell 2024 Apr 25;187(9):2288-2304.e27
Cell 2024 Apr 25;187(9):2288-2304.e27
Sp1 Regulates the M1 Polarization of Microglia Through the HuR/NF-κB Axis after Spinal Cord Injury.
Guo H, Du M, Yang Y, Lin X, Wang Y, Li H, Ren J, Xu W, Yan J, Wang N
Neuroscience 2024 Apr 19;544:50-63
Neuroscience 2024 Apr 19;544:50-63
hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1-mediated THBS1 transcription.
Ma X, Xu L, Gong S, Wu N, Guo J, Feng X, Zhao M, Qiu S, Sun M, Zhang C, Zhang X, Ren Z, Zhang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 15;38(7):e23591
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 15;38(7):e23591
Sichen Formula Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Blocking the TLR4 Signaling Pathways.
Yan LS, Cui S, Cheng BC, Yin XB, Wang YW, Qiu XY, Nima CR, Zhang Y, Zhang SF
Drug design, development and therapy 2023;17:297-312
Drug design, development and therapy 2023;17:297-312
Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer.
Mao D, Zhou Z, Chen H, Liu X, Li D, Chen X, He Y, Liu M, Zhang C
Cancer letters 2023 Sep 28;572:216351
Cancer letters 2023 Sep 28;572:216351
MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease.
Li X, Fan QL, Ma TK, Liu C, Shi H, Sun YY, Wang Y, Ding DX, Tang A, Qin Y, Yang Q, Ding H, Li HY, Fu WN
iScience 2023 Sep 15;26(9):107609
iScience 2023 Sep 15;26(9):107609
Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.
Luo Q, Pan Y, Fu Q, Zhang X, Zhou S, Yu P, Tian H, Liu P, Chen S, Zhang H, Qin T
Cell biology and toxicology 2023 Oct;39(5):2069-2087
Cell biology and toxicology 2023 Oct;39(5):2069-2087
Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation.
Wang X, Wang Y, Cao A, Luo Q, Chen D, Zhao W, Xu J, Li Q, Bu X, Quan J
Nature communications 2023 Oct 2;14(1):6132
Nature communications 2023 Oct 2;14(1):6132
Xuelian injection ameliorates complete Freund's adjuvant-induced acute arthritis in rats via inhibiting TLR4 signaling.
Yan LS, Cheng BC, Wang YW, Zhang SF, Qiu XY, Kang JY, Zhang C, Jia ZH, Luo G, Zhang Y
Heliyon 2023 Nov;9(11):e21635
Heliyon 2023 Nov;9(11):e21635
Elevated high-mannose N-glycans hamper endometrial decidualization.
Chen S, Zhang A, Li N, Wu H, Li Y, Liu S, Yan Q
iScience 2023 Nov 17;26(11):108170
iScience 2023 Nov 17;26(11):108170
SP1 transcriptionally regulates UBE2N expression to promote lung adenocarcinoma progression.
Li J, Qi C, Shao S, Chen Y, Peng Z, Shen Q, Zhang Z
Molecular biomedicine 2023 Mar 25;4(1):7
Molecular biomedicine 2023 Mar 25;4(1):7
Sp1 Upregulation Bolsters the Radioresistance of Glioblastoma Cells by Promoting Double Strand Breaks Repair.
Liu X, Sun C, Wang Q, Li P, Zhao T, Li Q
International journal of molecular sciences 2023 Jun 26;24(13)
International journal of molecular sciences 2023 Jun 26;24(13)
Downregulation of miR‑7 and miR‑153 is involved in Helicobacter pylori CagA induced gastric carcinogenesis and progression.
Song Y, Guo D, Liu JF, Ge LN, Liu P, Qu YM, Cong HY, Li T, Chang X, Wang YR, Shao LY, Du ZJ, Wang MY
International journal of oncology 2023 Jul;63(1)
International journal of oncology 2023 Jul;63(1)
The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy.
Zhao L, Xu H, Liu X, Cheng Y, Xie J
Journal of translational medicine 2023 Jul 10;21(1):455
Journal of translational medicine 2023 Jul 10;21(1):455
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes.
Tabei A, Sakairi T, Hamatani H, Ohishi Y, Watanabe M, Nakasatomi M, Ikeuchi H, Kaneko Y, Kopp JB, Hiromura K
American journal of physiology. Renal physiology 2023 Jul 1;325(1):F121-F133
American journal of physiology. Renal physiology 2023 Jul 1;325(1):F121-F133
JWA inhibits nicotine-induced lung cancer stemness and progression through CHRNA5/AKT-mediated JWA/SP1/CD44 axis.
Ding K, Jiang X, Ni J, Zhang C, Li A, Zhou J
Ecotoxicology and environmental safety 2023 Jul 1;259:115043
Ecotoxicology and environmental safety 2023 Jul 1;259:115043
Association analysis of DNA methylation and the tissue/developmental expression of the FUT3 gene in Meishan pigs.
Yang L, Liu L, Cheng J, Wu Z, Bao W, Wu S
Gene 2023 Jan 30;851:147016
Gene 2023 Jan 30;851:147016
Sp1 Controls the Basal Level of Interleukin-34 Transcription.
Lin M, Liu X, Zhang X, Wang H, Fang Y, Wu X, Yin A, Yang W, Zhang D, Li M, Zhang L, Ying S
Immunological investigations 2023 Feb;52(2):224-240
Immunological investigations 2023 Feb;52(2):224-240
DNMT1-mediated lncRNA IFFD controls the follicular development via targeting GLI1 by sponging miR-370.
Zhou X, He Y, Pan X, Quan H, He B, Li Y, Bai G, Li N, Zhang Z, Zhang H, Li J, Yuan X
Cell death and differentiation 2023 Feb;30(2):576-588
Cell death and differentiation 2023 Feb;30(2):576-588
Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage.
Bu H, Wang B, Wu Y, Li P, Cui Y, Jiang X, Yu X, Liu B, Tang M
Environmental science and pollution research international 2023 Dec;30(58):122165-122181
Environmental science and pollution research international 2023 Dec;30(58):122165-122181
LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis.
Sha L, Li J, Shen H, Wang Q, Meng P, Zhang X, Deng Y, Zhu W, Xu Q
Cell reports 2023 Aug 29;42(8):112975
Cell reports 2023 Aug 29;42(8):112975
SP1-Induced Upregulation of LncRNA AFAP1-AS1 Promotes Tumor Progression in Triple-Negative Breast Cancer by Regulating mTOR Pathway.
Li F, Xian D, Huang J, Nie L, Xie T, Sun Q, Zhang X, Zhou Y
International journal of molecular sciences 2023 Aug 29;24(17)
International journal of molecular sciences 2023 Aug 29;24(17)
Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.
Li MX, Wu XT, Jing WQ, Hou WK, Hu S, Yan W
Cell death & disease 2023 Aug 2;14(8):492
Cell death & disease 2023 Aug 2;14(8):492
JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice.
Xie Z, Wu XJ, Cheng RW, Cui JH, Yuan ST, Zhou JW, Liu QH
Acta pharmacologica Sinica 2023 Apr;44(4):897-912
Acta pharmacologica Sinica 2023 Apr;44(4):897-912
Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory activity on the transcription of CDH1 to promote the progression of prostate cancer.
Zhou J, Yan X, Liu Y, Yang J
Biochemical and biophysical research communications 2023 Apr 2;650:9-16
Biochemical and biophysical research communications 2023 Apr 2;650:9-16
Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis.
Liao C, Wang D, Qin S, Zhang Y, Chen J, Xu R, Xu F, Zhang P
Frontiers in pharmacology 2022;13:677738
Frontiers in pharmacology 2022;13:677738
Proteomic analysis reveals that ACSL4 activation during reflux esophagitis contributes to ferroptosis-mediated esophageal mucosal damage.
Liu S, Tang Y, Liu L, Yang L, Li P, Liu X, Yin H
European journal of pharmacology 2022 Sep 15;931:175175
European journal of pharmacology 2022 Sep 15;931:175175
SP1/miR-92a-1-5p/SOCS5: A novel regulatory axis in feline panleukopenia virus replication.
Liang R, Liang L, Zhao J, Liu W, Cui S, Zhang X, Zhang L
Veterinary microbiology 2022 Oct;273:109549
Veterinary microbiology 2022 Oct;273:109549
Macrophage-derived exosomal miR-4532 promotes endothelial cells injury by targeting SP1 and NF-κB P65 signalling activation.
Liu P, Wang S, Wang G, Zhao M, Du F, Li K, Wang L, Wu H, Chen J, Yang Y, Su G
Journal of cellular and molecular medicine 2022 Oct;26(20):5165-5180
Journal of cellular and molecular medicine 2022 Oct;26(20):5165-5180
Analysis of RIOK2 Functions in Mediating the Toxic Effects of Deoxynivalenol in Porcine Intestinal Epithelial Cells.
Gao Z, Xu C, Fan H, Wang H, Wu Z, Wu S, Bao W
International journal of molecular sciences 2022 Oct 22;23(21)
International journal of molecular sciences 2022 Oct 22;23(21)
NLRP3 Inflammasome Activation Enhances ADK Expression to Accelerate Epilepsy in Mice.
Zhang H, Yu S, Xia L, Peng X, Wang S, Yao B
Neurochemical research 2022 Mar;47(3):713-722
Neurochemical research 2022 Mar;47(3):713-722
O-GlcNAc modification mediates aquaporin 3 to coordinate endometrial cell glycolysis and affects embryo implantation.
Zhang H, Qi J, Pei J, Zhang M, Shang Y, Li Z, Wang Y, Guo J, Sun K, Fan J, Sui L, Xu Y, Kong L, Kong Y
Journal of advanced research 2022 Mar;37:119-131
Journal of advanced research 2022 Mar;37:119-131
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
Zheng X, Xiao J, Jiang Q, Zheng L, Liu C, Dong C, Zheng Y, Ni P, Zhang C, Zhang F, Zhong R, Ding H, Wang Q, Qiu Y, Gao M, Ding J, Shen N, Wei B, Wang H
The EMBO journal 2022 Mar 15;41(6):e108016
The EMBO journal 2022 Mar 15;41(6):e108016
Differential expression of placental 11β-HSD2 induced by high maternal glucocorticoid exposure mediates sex differences in placental and fetal development.
Yu P, Zhou J, Ge C, Fang M, Zhang Y, Wang H
The Science of the total environment 2022 Jun 25;827:154396
The Science of the total environment 2022 Jun 25;827:154396
High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein.
Shen Z, Wu J, Gao Z, Zhang S, Chen J, He J, Guo Y, Deng Q, Xie Y, Liu J, Zhang J
Nucleic acids research 2022 Feb 28;50(4):2157-2171
Nucleic acids research 2022 Feb 28;50(4):2157-2171
Intronic miR-140-5p contributes to beta-cypermethrin-mediated testosterone decline.
Duan P, Ha M, Huang X, Zhang P, Liu C
The Science of the total environment 2022 Feb 1;806(Pt 1):150517
The Science of the total environment 2022 Feb 1;806(Pt 1):150517
FBXL6 depletion restrains clear cell renal cell carcinoma progression.
Yu Y, Yao W, Wang T, Xue W, Meng Y, Cai L, Jian W, Yu Y, Zhang C
Translational oncology 2022 Dec;26:101550
Translational oncology 2022 Dec;26:101550
Sp1 Inhibits PGC-1α via HDAC2-Catalyzed Histone Deacetylation in Chronic Constriction Injury-Induced Neuropathic Pain.
Miao J, Chen Z, Wu Y, Hu Q, Ji T
ACS chemical neuroscience 2022 Dec 7;13(23):3438-3452
ACS chemical neuroscience 2022 Dec 7;13(23):3438-3452
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice.
Sha L, Li G, Zhang X, Lin Y, Qiu Y, Deng Y, Zhu W, Xu Q
JCI insight 2022 Aug 8;7(15)
JCI insight 2022 Aug 8;7(15)
Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis.
Angelini A, Ortiz-Urbina J, Trial J, Reddy AK, Malovannaya A, Jain A, Entman ML, Taffet GE, Cieslik KA
American journal of physiology. Heart and circulatory physiology 2022 Aug 1;323(2):H285-H300
American journal of physiology. Heart and circulatory physiology 2022 Aug 1;323(2):H285-H300
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Wang L, Lin Y, Zhou X, Chen Y, Li X, Luo W, Zhou Y, Cai L
Cancer letters 2022 Apr 28;532:215586
Cancer letters 2022 Apr 28;532:215586
Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland.
Shao C, Lou P, Liu R, Bi X, Li G, Yang X, Sheng X, Xu J, Lv C, Yu Z
Frontiers in cell and developmental biology 2021;9:691050
Frontiers in cell and developmental biology 2021;9:691050
Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling.
Wang S, Chang X, Zhang J, Li J, Wang N, Yang B, Pan B, Zheng Y, Wang X, Ou H, Wang Z
Frontiers in oncology 2021;11:745584
Frontiers in oncology 2021;11:745584
KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.
Wei H, Ma W, Lu X, Liu H, Lin K, Wang Y, Ye Z, Sun L, Huang Z, Pan T, Zhou Z, Cheng EY, Zhang H, Gao P, Zhong X
Cancer communications (London, England) 2021 Sep;41(9):904-920
Cancer communications (London, England) 2021 Sep;41(9):904-920
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.
Tao M, Luo J, Gu T, Yu X, Song Z, Jun Y, Gu H, Han K, Huang X, Yu W, Sun S, Zhang Z, Liu L, Chen X, Zhang L, Luo C, Wang Q
Cell death & disease 2021 Sep 13;12(9):845
Cell death & disease 2021 Sep 13;12(9):845
Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
Wang L, Chen X, Wang L, Wang S, Li W, Liu Y, Zhang J
IUBMB life 2021 Nov;73(11):1378-1391
IUBMB life 2021 Nov;73(11):1378-1391
Long non-coding RNA SNHG1 promotes fibroblast-to-myofibroblast transition during the development of pulmonary fibrosis induced by silica particles exposure.
Wu Q, Jiao B, Gui W, Zhang Q, Wang F, Han L
Ecotoxicology and environmental safety 2021 Nov 3;228:112938
Ecotoxicology and environmental safety 2021 Nov 3;228:112938
The function of BAP18 on modulation of androgen receptor action in luteinized granulosa cells from normal weight women with and without PCOS.
Tang T, Jiao J, Li D, Sun G, Lin L, Wang C, Wang S, Zou R, Liu W, Zhao Y, Wang X
Molecular and cellular endocrinology 2021 May 1;527:111228
Molecular and cellular endocrinology 2021 May 1;527:111228
Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer.
Zhang X, Li F, Zhou Y, Mao F, Lin Y, Shen S, Li Y, Zhang S, Sun Q
Cell death & disease 2021 Jun 18;12(7):627
Cell death & disease 2021 Jun 18;12(7):627
FHL1 promotes glioblastoma aggressiveness through regulating EGFR expression.
Sun L, Chen L, Zhu H, Li Y, Chen CC, Li M
FEBS letters 2021 Jan;595(1):85-98
FEBS letters 2021 Jan;595(1):85-98
PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism.
Ha M, Huang X, Li L, Lu D, Liu C
The Science of the total environment 2021 Feb 25;757:143727
The Science of the total environment 2021 Feb 25;757:143727
Abnormal nitration and S-sulfhydration modification of Sp1-CSE-H(2)S pathway trap the progress of hyperhomocysteinemia into a vicious cycle.
Luo C, Ji D, Li Y, Cao Y, Zhang S, Yan W, Xue K, Chai J, Wu Y, Liu H, Wang W
Free radical biology & medicine 2021 Feb 20;164:20-33
Free radical biology & medicine 2021 Feb 20;164:20-33
Triptolide impairs glycolysis by suppressing GATA4/Sp1/PFKP signaling axis in mouse Sertoli cells.
Zhang Y, Tang Y, Luo Y, Luo L, Shen F, Huang Z
Toxicology and applied pharmacology 2021 Aug 15;425:115606
Toxicology and applied pharmacology 2021 Aug 15;425:115606
SP1/AKT/FOXO3 Signaling Is Involved in miR-362-3p-Mediated Inhibition of Cell-Cycle Pathway and EMT Progression in Renal Cell Carcinoma.
Zhu H, Wang S, Shen H, Zheng X, Xu X
Frontiers in cell and developmental biology 2020;8:297
Frontiers in cell and developmental biology 2020;8:297
High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression.
Qi J, Wu Q, Cheng Q, Chen X, Zhu M, Miao C
Journal of diabetes research 2020;2020:2308520
Journal of diabetes research 2020;2020:2308520
Blocking circ_0000520 Suppressed Breast Cancer Cell Growth, Migration and Invasion Partially via miR-1296/SP1 Axis Both in vitro and in vivo.
Zang H, Li Y, Zhang X, Huang G
Cancer management and research 2020;12:7783-7795
Cancer management and research 2020;12:7783-7795
The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells.
Ming SL, Zeng L, Guo YK, Zhang S, Li GL, Ma YX, Zhai YY, Chang WR, Yang L, Wang J, Yang GY, Chu BB
Frontiers in immunology 2020;11:575818
Frontiers in immunology 2020;11:575818
JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin αvβ3 signaling.
Cui J, Shu C, Xu J, Chen D, Li J, Ding K, Chen M, Li A, He J, Shu Y, Yang L, Zhang R, Zhou J
Theranostics 2020;10(18):8036-8050
Theranostics 2020;10(18):8036-8050
Porcine Reproductive and Respiratory Syndrome Virus Structural Protein GP3 Regulates Claudin 4 To Facilitate the Early Stages of Infection.
Ding G, Liu J, Shao Q, Wang B, Feng J, Li Y, Li L, Cao S, Cong F, Zhao Y, Liu S, Xiao Y
Journal of virology 2020 Sep 29;94(20)
Journal of virology 2020 Sep 29;94(20)
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Liu X, Xu C, Xu L, Li X, Sun H, Xue M, Li T, Yu X, Sun B, Chen L
Metabolism: clinical and experimental 2020 Oct;111:154334
Metabolism: clinical and experimental 2020 Oct;111:154334
Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss.
Li X, Wang L, Huang B, Gu Y, Luo Y, Zhi X, Hu Y, Zhang H, Gu Z, Cui J, Cao L, Guo J, Wang Y, Zhou Q, Jiang H, Fang C, Weng W, Chen X, Chen X, Su J
Science advances 2020 Nov;6(47)
Science advances 2020 Nov;6(47)
miR-142-5p/DAX1-dependent regulation of P450c17 contributes to triclosan-mediated testosterone suppression.
Duan P, Huang X, Ha M, Li L, Liu C
The Science of the total environment 2020 May 15;717:137280
The Science of the total environment 2020 May 15;717:137280
JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis.
Chen JJ, Ren YL, Shu CJ, Zhang Y, Chen MJ, Xu J, Li J, Li AP, Chen DY, He JD, Shu YQ, Zhou JW
Journal of experimental & clinical cancer research : CR 2020 Jun 23;39(1):118
Journal of experimental & clinical cancer research : CR 2020 Jun 23;39(1):118
The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis.
Zhou Q, Wu X, Wang X, Yu Z, Pan T, Li Z, Chang X, Jin Z, Li J, Zhu Z, Liu B, Su L
Oncogene 2020 Feb;39(7):1414-1428
Oncogene 2020 Feb;39(7):1414-1428
RETRACTED: METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing.
Chen X, Xu M, Xu X, Zeng K, Liu X, Sun L, Pan B, He B, Pan Y, Sun H, Xia X, Wang S
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Feb 5;28(2):599-612
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Feb 5;28(2):599-612
MiRNA-130a-3p inhibits cell proliferation, migration, and TMZ resistance in glioblastoma by targeting Sp1.
Wang Z, Li Z, Fu Y, Han L, Tian Y
American journal of translational research 2019;11(12):7272-7285
American journal of translational research 2019;11(12):7272-7285
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X
Experimental cell research 2019 Oct 15;383(2):111512
Experimental cell research 2019 Oct 15;383(2):111512
Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells.
Zhang C, Wu Q, Huang H, Chen X, Huang T, Li W, Liu Y, Zhang J
Journal of physiology and biochemistry 2019 Nov;75(4):549-559
Journal of physiology and biochemistry 2019 Nov;75(4):549-559
The mechanism of SP1/p300 complex promotes proliferation of multiple myeloma cells through regulating IQGAP1 transcription.
Jin Z, Zhou S, Ye H, Jiang S, Yu K, Ma Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109434
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109434
HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I.
Rushing AW, Rushing B, Hoang K, Sanders SV, Péloponèse JM Jr, Polakowski N, Lemasson I
PLoS pathogens 2019 Jun;15(6):e1007922
PLoS pathogens 2019 Jun;15(6):e1007922
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Sun Z, Liu Y, Yu F, Xu Y, Yanli L, Liu N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Involvement of multiple transcription factors in regulation of IL-β-induced MCP-1 expression in alveolar type II epithelial cells.
Yan C, Li B, Liu X, Deng C, Cai R, Shen Y, Tang H
Molecular immunology 2019 Jul;111:95-105
Molecular immunology 2019 Jul;111:95-105
Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.
Dąbrowska K, Zielińska M
International journal of molecular sciences 2019 Jan 9;20(2)
International journal of molecular sciences 2019 Jan 9;20(2)
MIR-300 in the imprinted DLK1-DIO3 domain suppresses the migration of bladder cancer by regulating the SP1/MMP9 pathway.
Yan H, Li J, Ying Y, Xie H, Chen H, Xu X, Zheng X
Cell cycle (Georgetown, Tex.) 2018;17(24):2790-2801
Cell cycle (Georgetown, Tex.) 2018;17(24):2790-2801
Sp1 Suppresses miR-3178 to Promote the Metastasis Invasion Cascade via Upregulation of TRIOBP.
Wang H, Li K, Mei Y, Huang X, Li Z, Yang Q, Yang H
Molecular therapy. Nucleic acids 2018 Sep 7;12:1-11
Molecular therapy. Nucleic acids 2018 Sep 7;12:1-11
2-(2-nitrobenzylidene) indolin-3-one compound inhibits transmembrane prostate androgen-induced protein (TMEPAI) expression and cancer cell proliferation.
Li Y, Wang J, Song N, Zeng F, Zhao M, Wang A, Chen Y, Jing L, Yu P, Diao A
Cell proliferation 2018 Oct;51(5):e12469
Cell proliferation 2018 Oct;51(5):e12469
Long non-coding RNA FTH1P3 regulated metastasis and invasion of esophageal squamous cell carcinoma through SP1/NF-kB pathway.
Yang L, Sun K, Chu J, Qu Y, Zhao X, Yin H, Ming L, Wan J, He F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1570-1577
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1570-1577
Sp1-regulated transcription of RasGRP1 promotes hepatocellular carcinoma (HCC) proliferation.
Zhang X, Zhuang H, Han F, Shao X, Liu Y, Ma X, Wang Z, Qiang Z, Li Y
Liver international : official journal of the International Association for the Study of the Liver 2018 Nov;38(11):2006-2017
Liver international : official journal of the International Association for the Study of the Liver 2018 Nov;38(11):2006-2017
Fatty acid elongase7 is regulated via SP1 and is involved in lipid accumulation in bovine mammary epithelial cells.
Chen S, Hu Z, He H, Liu X
Journal of cellular physiology 2018 Jun;233(6):4715-4725
Journal of cellular physiology 2018 Jun;233(6):4715-4725
Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma.
Cheng Y, Zhao P, Wu S, Yang T, Chen Y, Zhang X, He C, Zheng C, Li K, Ma X, Xiang G
International journal of pharmaceutics 2018 Jul 10;545(1-2):261-273
International journal of pharmaceutics 2018 Jul 10;545(1-2):261-273
Improved Sp1 and Betaine Homocysteine-S-Methyltransferase Expression and Homocysteine Clearance Are Involved in the Effects of Zinc on Oxidative Stress in High-Fat-Diet-Pretreated Mice.
Wu L, Zhou X, Li T, He J, Huang L, Ouyang Z, He L, Wei T, He Q
Biological trace element research 2018 Aug;184(2):436-441
Biological trace element research 2018 Aug;184(2):436-441
Glucocorticoids regulate MiR-29c levels in vascular smooth muscle cells through transcriptional and epigenetic mechanisms.
Chuang TD, Khorram O
Life sciences 2017 Oct 1;186:87-91
Life sciences 2017 Oct 1;186:87-91
ICAM-1 regulates macrophage polarization by suppressing MCP-1 expression via miR-124 upregulation.
Gu W, Yao L, Li L, Zhang J, Place AT, Minshall RD, Liu G
Oncotarget 2017 Dec 19;8(67):111882-111901
Oncotarget 2017 Dec 19;8(67):111882-111901
A G-quadruplex structure at the 5' end of the H19 coding region regulates H19 transcription.
Fukuhara M, Ma Y, Nagasawa K, Toyoshima F
Scientific reports 2017 Apr 3;8:45815
Scientific reports 2017 Apr 3;8:45815
Hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance and Replication through Two Distinct Mechanisms.
Ren S, Wang J, Chen TL, Li HY, Wan YS, Peng NF, Gui XE, Zhu Y
PloS one 2016;11(3):e0152721
PloS one 2016;11(3):e0152721
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Huang D, Li T, Wang L, Zhang L, Yan R, Li K, Xing S, Wu G, Hu L, Jia W, Lin SC, Dang CV, Song L, Gao P, Zhang H
Cell research 2016 Oct;26(10):1112-1130
Cell research 2016 Oct;26(10):1112-1130
Hepatitis B virus X protein up-regulates C4b-binding protein α through activating transcription factor Sp1 in protection of hepatoma cells from complement attack.
Feng G, Li J, Zheng M, Yang Z, Liu Y, Zhang S, Ye L, Zhang W, Zhang X
Oncotarget 2016 May 10;7(19):28013-26
Oncotarget 2016 May 10;7(19):28013-26
Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.
Aziz F, Wang X, Liu J, Yan Q
Toxicology in vitro : an international journal published in association with BIBRA 2016 Mar;31:158-66
Toxicology in vitro : an international journal published in association with BIBRA 2016 Mar;31:158-66
MiR-24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1.
Kang M, Xiao J, Wang J, Zhou P, Wei T, Zhao T, Wang R
Cancer medicine 2016 Jun;5(6):1163-73
Cancer medicine 2016 Jun;5(6):1163-73
Mechanisms underlying aberrant expression of miR-29c in uterine leiomyoma.
Chuang TD, Khorram O
Fertility and sterility 2016 Jan;105(1):236-45.e1
Fertility and sterility 2016 Jan;105(1):236-45.e1
The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells.
Shi H, Li Y, Feng G, Li L, Fang R, Wang Z, Qu J, Ding P, Zhang X, Ye L
Biochemical and biophysical research communications 2016 Feb 26;471(1):89-94
Biochemical and biophysical research communications 2016 Feb 26;471(1):89-94
SP1-mediated microRNA-520d-5p suppresses tumor growth and metastasis in colorectal cancer by targeting CTHRC1.
Yan L, Yu J, Tan F, Ye GT, Shen ZY, Liu H, Zhang Y, Wang JF, Zhu XJ, Li GX
American journal of cancer research 2015;5(4):1447-59
American journal of cancer research 2015;5(4):1447-59
Mature miR-183, negatively regulated by transcription factor GATA3, promotes 3T3-L1 adipogenesis through inhibition of the canonical Wnt/β-catenin signaling pathway by targeting LRP6.
Chen C, Xiang H, Peng YL, Peng J, Jiang SW
Cellular signalling 2014 Jun;26(6):1155-65
Cellular signalling 2014 Jun;26(6):1155-65
UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.
Wen Y, Li J, Wang L, Tie K, Magdalou J, Chen L, Wang H
Arthritis research & therapy 2014 Dec 3;16(6):484
Arthritis research & therapy 2014 Dec 3;16(6):484
Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth.
Hsu TI, Wang MC, Chen SY, Huang ST, Yeh YM, Su WC, Chang WC, Hung JJ
Molecular pharmacology 2012 Dec;82(6):1115-28
Molecular pharmacology 2012 Dec;82(6):1115-28
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 21962-1-AP(SP1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-SP1 (IP:21962-1-AP, 6ug; Detection:21962-1-AP 1:500) with A431 cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 21962-1-AP(SP1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SP1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SP1. This antibody recognizes human,mouse,rat antigen. The SP1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
