21962-1-AP

antibody from Proteintech Group

Targeting: SP1

Provider product page for 21962-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [101]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]
Immunohistochemistry [2]

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Product number: 21962-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21962-1-AP, RRID:AB_10898171
Product name: SP1 antibody
Antibody type: Polyclonal
Description: KD/KO validated SP1 antibody (Cat. #21962-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, monkey and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat, Simian
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SP1 protein structure - 21962-1-AP shown in red.

Submitted references Ferrostatin-1 improves neurological impairment induced by ischemia/reperfusion injury in the spinal cord through ERK1/2/SP1/GPX4.

Liu S, Chen F, Han J, Wang L, Dong Y
Experimental neurology 2024 Mar;373:114659

DNA hypomethylation of Syk induces oxidative stress and apoptosis via the PKCβ/P66shc signaling pathway in diabetic kidney disease.

Zhang R, Qin C, Zhang J, HonghongRen, Wang Y, Wu Y, Zhao L, Wang J, Zhang J, Liu F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 31;38(6):e23564

GITR exacerbates lysophosphatidylcholine-induced macrophage pyroptosis in sepsis via posttranslational regulation of NLRP3.

Liang S, Zhou J, Cao C, Liu Y, Ming S, Liu X, Shang Y, Lao J, Peng Q, Yang J, Wu M
Cellular & molecular immunology 2024 Jul;21(7):674-688

SMYD5 is a regulator of the mild hypothermia response.

Rafnsdottir S, Jang K, Halldorsdottir ST, Vinod M, Tomasdottir A, Möller K, Halldorsdottir K, Reynisdottir T, Atladottir LH, Allison KE, Ostacolo K, He J, Zhang L, Northington FJ, Magnusdottir E, Chavez-Valdez R, Anderson KJ, Bjornsson HT
bioRxiv : the preprint server for biology 2024 Jul 12;

HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis.

Yang K, Li J, Zhu J, Chen Y, He Y, Wang J, Shen K, Wang K, Shi T, Chen W
Cell death discovery 2024 Jan 16;10(1):33

Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma.

Wang S, Zhu L, Li T, Lin X, Zheng Y, Xu D, Guo Y, Zhang Z, Fu Y, Wang H, Wang X, Zou T, Shen X, Zhang L, Lai N, Lu L, Qin L, Dong Q
Cell reports. Medicine 2024 Feb 20;5(2):101415

Dysregulation of Glucocorticoid Receptor Homeostasis and Glucocorticoid-Associated Genes in Umbilical Cord Endothelial Cells of Diet-Induced Obese Pregnant Sheep.

Mata-Greenwood E, Chow WL, Anti NAO, Sands LD, Adeoye O, Ford SP, Nathanielsz PW
International journal of molecular sciences 2024 Feb 15;25(4)

Canagliflozin protects against hyperglycemia-induced cerebrovascular injury by preventing blood-brain barrier (BBB) disruption via AMPK/Sp1/adenosine A2A receptor.

Liu Z, Hua W, Jin S, Wang Y, Pang Y, Wang B, Zhao N, Song Y, Qi J
European journal of pharmacology 2024 Apr 5;968:176381

Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8(+) T cells.

Cao T, Zhang W, Wang Q, Wang C, Ma W, Zhang C, Ge M, Tian M, Yu J, Jiao A, Wang L, Liu M, Wang P, Guo Z, Zhou Y, Chen S, Yin W, Yi J, Guo H, Han H, Zhang B, Wu K, Fan D, Wang X, Nie Y, Lu Y, Zhao X
Cell 2024 Apr 25;187(9):2288-2304.e27

Sp1 Regulates the M1 Polarization of Microglia Through the HuR/NF-κB Axis after Spinal Cord Injury.

Guo H, Du M, Yang Y, Lin X, Wang Y, Li H, Ren J, Xu W, Yan J, Wang N
Neuroscience 2024 Apr 19;544:50-63

hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1-mediated THBS1 transcription.

Ma X, Xu L, Gong S, Wu N, Guo J, Feng X, Zhao M, Qiu S, Sun M, Zhang C, Zhang X, Ren Z, Zhang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 15;38(7):e23591

Sichen Formula Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Blocking the TLR4 Signaling Pathways.

Yan LS, Cui S, Cheng BC, Yin XB, Wang YW, Qiu XY, Nima CR, Zhang Y, Zhang SF
Drug design, development and therapy 2023;17:297-312

Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer.

Mao D, Zhou Z, Chen H, Liu X, Li D, Chen X, He Y, Liu M, Zhang C
Cancer letters 2023 Sep 28;572:216351

MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease.

Li X, Fan QL, Ma TK, Liu C, Shi H, Sun YY, Wang Y, Ding DX, Tang A, Qin Y, Yang Q, Ding H, Li HY, Fu WN
iScience 2023 Sep 15;26(9):107609

Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.

Luo Q, Pan Y, Fu Q, Zhang X, Zhou S, Yu P, Tian H, Liu P, Chen S, Zhang H, Qin T
Cell biology and toxicology 2023 Oct;39(5):2069-2087

Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation.

Wang X, Wang Y, Cao A, Luo Q, Chen D, Zhao W, Xu J, Li Q, Bu X, Quan J
Nature communications 2023 Oct 2;14(1):6132

Xuelian injection ameliorates complete Freund's adjuvant-induced acute arthritis in rats via inhibiting TLR4 signaling.

Yan LS, Cheng BC, Wang YW, Zhang SF, Qiu XY, Kang JY, Zhang C, Jia ZH, Luo G, Zhang Y
Heliyon 2023 Nov;9(11):e21635

Elevated high-mannose N-glycans hamper endometrial decidualization.

Chen S, Zhang A, Li N, Wu H, Li Y, Liu S, Yan Q
iScience 2023 Nov 17;26(11):108170

Sp1 Upregulation Bolsters the Radioresistance of Glioblastoma Cells by Promoting Double Strand Breaks Repair.

Liu X, Sun C, Wang Q, Li P, Zhao T, Li Q
International journal of molecular sciences 2023 Jun 26;24(13)

Downregulation of miR‑7 and miR‑153 is involved in Helicobacter pylori CagA induced gastric carcinogenesis and progression.

Song Y, Guo D, Liu JF, Ge LN, Liu P, Qu YM, Cong HY, Li T, Chang X, Wang YR, Shao LY, Du ZJ, Wang MY
International journal of oncology 2023 Jul;63(1)

The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy.

Zhao L, Xu H, Liu X, Cheng Y, Xie J
Journal of translational medicine 2023 Jul 10;21(1):455

The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes.

Tabei A, Sakairi T, Hamatani H, Ohishi Y, Watanabe M, Nakasatomi M, Ikeuchi H, Kaneko Y, Kopp JB, Hiromura K
American journal of physiology. Renal physiology 2023 Jul 1;325(1):F121-F133

JWA inhibits nicotine-induced lung cancer stemness and progression through CHRNA5/AKT-mediated JWA/SP1/CD44 axis.

Ding K, Jiang X, Ni J, Zhang C, Li A, Zhou J
Ecotoxicology and environmental safety 2023 Jul 1;259:115043

Association analysis of DNA methylation and the tissue/developmental expression of the FUT3 gene in Meishan pigs.

Yang L, Liu L, Cheng J, Wu Z, Bao W, Wu S
Gene 2023 Jan 30;851:147016

Sp1 Controls the Basal Level of Interleukin-34 Transcription.

Lin M, Liu X, Zhang X, Wang H, Fang Y, Wu X, Yin A, Yang W, Zhang D, Li M, Zhang L, Ying S
Immunological investigations 2023 Feb;52(2):224-240

DNMT1-mediated lncRNA IFFD controls the follicular development via targeting GLI1 by sponging miR-370.

Zhou X, He Y, Pan X, Quan H, He B, Li Y, Bai G, Li N, Zhang Z, Zhang H, Li J, Yuan X
Cell death and differentiation 2023 Feb;30(2):576-588

Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage.

Bu H, Wang B, Wu Y, Li P, Cui Y, Jiang X, Yu X, Liu B, Tang M
Environmental science and pollution research international 2023 Dec;30(58):122165-122181

LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis.

Sha L, Li J, Shen H, Wang Q, Meng P, Zhang X, Deng Y, Zhu W, Xu Q
Cell reports 2023 Aug 29;42(8):112975

SP1-Induced Upregulation of LncRNA AFAP1-AS1 Promotes Tumor Progression in Triple-Negative Breast Cancer by Regulating mTOR Pathway.

Li F, Xian D, Huang J, Nie L, Xie T, Sun Q, Zhang X, Zhou Y
International journal of molecular sciences 2023 Aug 29;24(17)

Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.

Li MX, Wu XT, Jing WQ, Hou WK, Hu S, Yan W
Cell death & disease 2023 Aug 2;14(8):492

JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice.

Xie Z, Wu XJ, Cheng RW, Cui JH, Yuan ST, Zhou JW, Liu QH
Acta pharmacologica Sinica 2023 Apr;44(4):897-912

Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory activity on the transcription of CDH1 to promote the progression of prostate cancer.

Zhou J, Yan X, Liu Y, Yang J
Biochemical and biophysical research communications 2023 Apr 2;650:9-16

Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis.

Liao C, Wang D, Qin S, Zhang Y, Chen J, Xu R, Xu F, Zhang P
Frontiers in pharmacology 2022;13:677738

Proteomic analysis reveals that ACSL4 activation during reflux esophagitis contributes to ferroptosis-mediated esophageal mucosal damage.

Liu S, Tang Y, Liu L, Yang L, Li P, Liu X, Yin H
European journal of pharmacology 2022 Sep 15;931:175175

SP1/miR-92a-1-5p/SOCS5: A novel regulatory axis in feline panleukopenia virus replication.

Liang R, Liang L, Zhao J, Liu W, Cui S, Zhang X, Zhang L
Veterinary microbiology 2022 Oct;273:109549

Macrophage-derived exosomal miR-4532 promotes endothelial cells injury by targeting SP1 and NF-κB P65 signalling activation.

Liu P, Wang S, Wang G, Zhao M, Du F, Li K, Wang L, Wu H, Chen J, Yang Y, Su G
Journal of cellular and molecular medicine 2022 Oct;26(20):5165-5180

NLRP3 Inflammasome Activation Enhances ADK Expression to Accelerate Epilepsy in Mice.

Zhang H, Yu S, Xia L, Peng X, Wang S, Yao B
Neurochemical research 2022 Mar;47(3):713-722

O-GlcNAc modification mediates aquaporin 3 to coordinate endometrial cell glycolysis and affects embryo implantation.

Zhang H, Qi J, Pei J, Zhang M, Shang Y, Li Z, Wang Y, Guo J, Sun K, Fan J, Sui L, Xu Y, Kong L, Kong Y
Journal of advanced research 2022 Mar;37:119-131

AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.

Zheng X, Xiao J, Jiang Q, Zheng L, Liu C, Dong C, Zheng Y, Ni P, Zhang C, Zhang F, Zhong R, Ding H, Wang Q, Qiu Y, Gao M, Ding J, Shen N, Wei B, Wang H
The EMBO journal 2022 Mar 15;41(6):e108016

Differential expression of placental 11β-HSD2 induced by high maternal glucocorticoid exposure mediates sex differences in placental and fetal development.

Yu P, Zhou J, Ge C, Fang M, Zhang Y, Wang H
The Science of the total environment 2022 Jun 25;827:154396

High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein.

Shen Z, Wu J, Gao Z, Zhang S, Chen J, He J, Guo Y, Deng Q, Xie Y, Liu J, Zhang J
Nucleic acids research 2022 Feb 28;50(4):2157-2171

Intronic miR-140-5p contributes to beta-cypermethrin-mediated testosterone decline.

Duan P, Ha M, Huang X, Zhang P, Liu C
The Science of the total environment 2022 Feb 1;806(Pt 1):150517

FBXL6 depletion restrains clear cell renal cell carcinoma progression.

Yu Y, Yao W, Wang T, Xue W, Meng Y, Cai L, Jian W, Yu Y, Zhang C
Translational oncology 2022 Dec;26:101550

Sp1 Inhibits PGC-1α via HDAC2-Catalyzed Histone Deacetylation in Chronic Constriction Injury-Induced Neuropathic Pain.

Miao J, Chen Z, Wu Y, Hu Q, Ji T
ACS chemical neuroscience 2022 Dec 7;13(23):3438-3452

Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice.

Sha L, Li G, Zhang X, Lin Y, Qiu Y, Deng Y, Zhu W, Xu Q
JCI insight 2022 Aug 8;7(15)

Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis.

Angelini A, Ortiz-Urbina J, Trial J, Reddy AK, Malovannaya A, Jain A, Entman ML, Taffet GE, Cieslik KA
American journal of physiology. Heart and circulatory physiology 2022 Aug 1;323(2):H285-H300

CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.

Wang L, Lin Y, Zhou X, Chen Y, Li X, Luo W, Zhou Y, Cai L
Cancer letters 2022 Apr 28;532:215586

Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland.

Shao C, Lou P, Liu R, Bi X, Li G, Yang X, Sheng X, Xu J, Lv C, Yu Z
Frontiers in cell and developmental biology 2021;9:691050

Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling.

Wang S, Chang X, Zhang J, Li J, Wang N, Yang B, Pan B, Zheng Y, Wang X, Ou H, Wang Z
Frontiers in oncology 2021;11:745584

KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.

Wei H, Ma W, Lu X, Liu H, Lin K, Wang Y, Ye Z, Sun L, Huang Z, Pan T, Zhou Z, Cheng EY, Zhang H, Gao P, Zhong X
Cancer communications (London, England) 2021 Sep;41(9):904-920

LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.

Tao M, Luo J, Gu T, Yu X, Song Z, Jun Y, Gu H, Han K, Huang X, Yu W, Sun S, Zhang Z, Liu L, Chen X, Zhang L, Luo C, Wang Q
Cell death & disease 2021 Sep 13;12(9):845

Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.

Wang L, Chen X, Wang L, Wang S, Li W, Liu Y, Zhang J
IUBMB life 2021 Nov;73(11):1378-1391

Long non-coding RNA SNHG1 promotes fibroblast-to-myofibroblast transition during the development of pulmonary fibrosis induced by silica particles exposure.

Wu Q, Jiao B, Gui W, Zhang Q, Wang F, Han L
Ecotoxicology and environmental safety 2021 Nov 3;228:112938

The function of BAP18 on modulation of androgen receptor action in luteinized granulosa cells from normal weight women with and without PCOS.

Tang T, Jiao J, Li D, Sun G, Lin L, Wang C, Wang S, Zou R, Liu W, Zhao Y, Wang X
Molecular and cellular endocrinology 2021 May 1;527:111228

Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer.

Zhang X, Li F, Zhou Y, Mao F, Lin Y, Shen S, Li Y, Zhang S, Sun Q
Cell death & disease 2021 Jun 18;12(7):627

FHL1 promotes glioblastoma aggressiveness through regulating EGFR expression.

Sun L, Chen L, Zhu H, Li Y, Chen CC, Li M
FEBS letters 2021 Jan;595(1):85-98

PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism.

Ha M, Huang X, Li L, Lu D, Liu C
The Science of the total environment 2021 Feb 25;757:143727

Abnormal nitration and S-sulfhydration modification of Sp1-CSE-H(2)S pathway trap the progress of hyperhomocysteinemia into a vicious cycle.

Luo C, Ji D, Li Y, Cao Y, Zhang S, Yan W, Xue K, Chai J, Wu Y, Liu H, Wang W
Free radical biology & medicine 2021 Feb 20;164:20-33

Triptolide impairs glycolysis by suppressing GATA4/Sp1/PFKP signaling axis in mouse Sertoli cells.

Zhang Y, Tang Y, Luo Y, Luo L, Shen F, Huang Z
Toxicology and applied pharmacology 2021 Aug 15;425:115606

SP1/AKT/FOXO3 Signaling Is Involved in miR-362-3p-Mediated Inhibition of Cell-Cycle Pathway and EMT Progression in Renal Cell Carcinoma.

Zhu H, Wang S, Shen H, Zheng X, Xu X
Frontiers in cell and developmental biology 2020;8:297

High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression.

Qi J, Wu Q, Cheng Q, Chen X, Zhu M, Miao C
Journal of diabetes research 2020;2020:2308520

Blocking circ_0000520 Suppressed Breast Cancer Cell Growth, Migration and Invasion Partially via miR-1296/SP1 Axis Both in vitro and in vivo.

Zang H, Li Y, Zhang X, Huang G
Cancer management and research 2020;12:7783-7795

The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells.

Ming SL, Zeng L, Guo YK, Zhang S, Li GL, Ma YX, Zhai YY, Chang WR, Yang L, Wang J, Yang GY, Chu BB
Frontiers in immunology 2020;11:575818

JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin αvβ3 signaling.

Cui J, Shu C, Xu J, Chen D, Li J, Ding K, Chen M, Li A, He J, Shu Y, Yang L, Zhang R, Zhou J
Theranostics 2020;10(18):8036-8050

Porcine Reproductive and Respiratory Syndrome Virus Structural Protein GP3 Regulates Claudin 4 To Facilitate the Early Stages of Infection.

Ding G, Liu J, Shao Q, Wang B, Feng J, Li Y, Li L, Cao S, Cong F, Zhao Y, Liu S, Xiao Y
Journal of virology 2020 Sep 29;94(20)

Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.

Liu X, Xu C, Xu L, Li X, Sun H, Xue M, Li T, Yu X, Sun B, Chen L
Metabolism: clinical and experimental 2020 Oct;111:154334

Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss.

Li X, Wang L, Huang B, Gu Y, Luo Y, Zhi X, Hu Y, Zhang H, Gu Z, Cui J, Cao L, Guo J, Wang Y, Zhou Q, Jiang H, Fang C, Weng W, Chen X, Chen X, Su J
Science advances 2020 Nov;6(47)

miR-142-5p/DAX1-dependent regulation of P450c17 contributes to triclosan-mediated testosterone suppression.

Duan P, Huang X, Ha M, Li L, Liu C
The Science of the total environment 2020 May 15;717:137280

JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis.

Chen JJ, Ren YL, Shu CJ, Zhang Y, Chen MJ, Xu J, Li J, Li AP, Chen DY, He JD, Shu YQ, Zhou JW
Journal of experimental & clinical cancer research : CR 2020 Jun 23;39(1):118

The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis.

Zhou Q, Wu X, Wang X, Yu Z, Pan T, Li Z, Chang X, Jin Z, Li J, Zhu Z, Liu B, Su L
Oncogene 2020 Feb;39(7):1414-1428

RETRACTED: METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing.

Chen X, Xu M, Xu X, Zeng K, Liu X, Sun L, Pan B, He B, Pan Y, Sun H, Xia X, Wang S
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Feb 5;28(2):599-612

MiRNA-130a-3p inhibits cell proliferation, migration, and TMZ resistance in glioblastoma by targeting Sp1.

Wang Z, Li Z, Fu Y, Han L, Tian Y
American journal of translational research 2019;11(12):7272-7285

OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.

Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X
Experimental cell research 2019 Oct 15;383(2):111512

Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells.

Zhang C, Wu Q, Huang H, Chen X, Huang T, Li W, Liu Y, Zhang J
Journal of physiology and biochemistry 2019 Nov;75(4):549-559

The mechanism of SP1/p300 complex promotes proliferation of multiple myeloma cells through regulating IQGAP1 transcription.

Jin Z, Zhou S, Ye H, Jiang S, Yu K, Ma Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109434

HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I.

Rushing AW, Rushing B, Hoang K, Sanders SV, Péloponèse JM Jr, Polakowski N, Lemasson I
PLoS pathogens 2019 Jun;15(6):e1007922

Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.

Sun Z, Liu Y, Yu F, Xu Y, Yanli L, Liu N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933

Involvement of multiple transcription factors in regulation of IL-β-induced MCP-1 expression in alveolar type II epithelial cells.

Yan C, Li B, Liu X, Deng C, Cai R, Shen Y, Tang H
Molecular immunology 2019 Jul;111:95-105

Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.

Dąbrowska K, Zielińska M
International journal of molecular sciences 2019 Jan 9;20(2)

MIR-300 in the imprinted DLK1-DIO3 domain suppresses the migration of bladder cancer by regulating the SP1/MMP9 pathway.

Yan H, Li J, Ying Y, Xie H, Chen H, Xu X, Zheng X
Cell cycle (Georgetown, Tex.) 2018;17(24):2790-2801

Sp1 Suppresses miR-3178 to Promote the Metastasis Invasion Cascade via Upregulation of TRIOBP.

Wang H, Li K, Mei Y, Huang X, Li Z, Yang Q, Yang H
Molecular therapy. Nucleic acids 2018 Sep 7;12:1-11

2-(2-nitrobenzylidene) indolin-3-one compound inhibits transmembrane prostate androgen-induced protein (TMEPAI) expression and cancer cell proliferation.

Li Y, Wang J, Song N, Zeng F, Zhao M, Wang A, Chen Y, Jing L, Yu P, Diao A
Cell proliferation 2018 Oct;51(5):e12469

Long non-coding RNA FTH1P3 regulated metastasis and invasion of esophageal squamous cell carcinoma through SP1/NF-kB pathway.

Yang L, Sun K, Chu J, Qu Y, Zhao X, Yin H, Ming L, Wan J, He F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1570-1577

Sp1-regulated transcription of RasGRP1 promotes hepatocellular carcinoma (HCC) proliferation.

Zhang X, Zhuang H, Han F, Shao X, Liu Y, Ma X, Wang Z, Qiang Z, Li Y
Liver international : official journal of the International Association for the Study of the Liver 2018 Nov;38(11):2006-2017

Fatty acid elongase7 is regulated via SP1 and is involved in lipid accumulation in bovine mammary epithelial cells.

Chen S, Hu Z, He H, Liu X
Journal of cellular physiology 2018 Jun;233(6):4715-4725

Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma.

Cheng Y, Zhao P, Wu S, Yang T, Chen Y, Zhang X, He C, Zheng C, Li K, Ma X, Xiang G
International journal of pharmaceutics 2018 Jul 10;545(1-2):261-273

Improved Sp1 and Betaine Homocysteine-S-Methyltransferase Expression and Homocysteine Clearance Are Involved in the Effects of Zinc on Oxidative Stress in High-Fat-Diet-Pretreated Mice.

Wu L, Zhou X, Li T, He J, Huang L, Ouyang Z, He L, Wei T, He Q
Biological trace element research 2018 Aug;184(2):436-441

Glucocorticoids regulate MiR-29c levels in vascular smooth muscle cells through transcriptional and epigenetic mechanisms.

Chuang TD, Khorram O
Life sciences 2017 Oct 1;186:87-91

ICAM-1 regulates macrophage polarization by suppressing MCP-1 expression via miR-124 upregulation.

Gu W, Yao L, Li L, Zhang J, Place AT, Minshall RD, Liu G
Oncotarget 2017 Dec 19;8(67):111882-111901

A G-quadruplex structure at the 5' end of the H19 coding region regulates H19 transcription.

Fukuhara M, Ma Y, Nagasawa K, Toyoshima F
Scientific reports 2017 Apr 3;8:45815

Hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance and Replication through Two Distinct Mechanisms.

Ren S, Wang J, Chen TL, Li HY, Wan YS, Peng NF, Gui XE, Zhu Y
PloS one 2016;11(3):e0152721

Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.

Huang D, Li T, Wang L, Zhang L, Yan R, Li K, Xing S, Wu G, Hu L, Jia W, Lin SC, Dang CV, Song L, Gao P, Zhang H
Cell research 2016 Oct;26(10):1112-1130

Hepatitis B virus X protein up-regulates C4b-binding protein α through activating transcription factor Sp1 in protection of hepatoma cells from complement attack.

Feng G, Li J, Zheng M, Yang Z, Liu Y, Zhang S, Ye L, Zhang W, Zhang X
Oncotarget 2016 May 10;7(19):28013-26

Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.

Aziz F, Wang X, Liu J, Yan Q
Toxicology in vitro : an international journal published in association with BIBRA 2016 Mar;31:158-66

MiR-24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1.

Kang M, Xiao J, Wang J, Zhou P, Wei T, Zhao T, Wang R
Cancer medicine 2016 Jun;5(6):1163-73

Mechanisms underlying aberrant expression of miR-29c in uterine leiomyoma.

Chuang TD, Khorram O
Fertility and sterility 2016 Jan;105(1):236-45.e1

The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells.

Shi H, Li Y, Feng G, Li L, Fang R, Wang Z, Qu J, Ding P, Zhang X, Ye L
Biochemical and biophysical research communications 2016 Feb 26;471(1):89-94

SP1-mediated microRNA-520d-5p suppresses tumor growth and metastasis in colorectal cancer by targeting CTHRC1.

Yan L, Yu J, Tan F, Ye GT, Shen ZY, Liu H, Zhang Y, Wang JF, Zhu XJ, Li GX
American journal of cancer research 2015;5(4):1447-59

Mature miR-183, negatively regulated by transcription factor GATA3, promotes 3T3-L1 adipogenesis through inhibition of the canonical Wnt/β-catenin signaling pathway by targeting LRP6.

Chen C, Xiang H, Peng YL, Peng J, Jiang SW
Cellular signalling 2014 Jun;26(6):1155-65

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.

Wen Y, Li J, Wang L, Tie K, Magdalou J, Chen L, Wang H
Arthritis research & therapy 2014 Dec 3;16(6):484

Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth.

Hsu TI, Wang MC, Chen SY, Huang ST, Yeh YM, Su WC, Chang WC, Hung JJ
Molecular pharmacology 2012 Dec;82(6):1115-28

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 21962-1-AP(SP1 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-SP1 (IP:21962-1-AP, 6ug; Detection:21962-1-AP 1:500) with A431 cells lysate 2500ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 21962-1-AP(SP1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SP1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SP1. This antibody recognizes human,mouse,rat antigen. The SP1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
Appendix: 21962-1-AP.pdf

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