25-9322-82

antibody from Invitrogen Antibodies
Targeting: ZBTB16 PLZF, ZNF145
Provider product page for 25-9322-82

Antibody data

Product number
25-9322-82 - Provider product page
Provider
Invitrogen Antibodies
Product name
PLZF Monoclonal Antibody (9E12), PE-Cyanine7, eBioscience™
Antibody type
Monoclonal
Antigen
Synthetic peptide
Description
This 9E12 monoclonal antibody reacts with human and mouse promyelocytic leukemia zinc finger (PLZF), a member of the BTB-POZ family of transcription factors. Expression of this transcriptional repressor in immune cells differs between mice and humans. In mice, PLZF is highly expressed in immature CD1d-resricted NKT2 and NKT1 cells, and a subset of gamma delta (Vg1.1+Vd6.3+) T cells. Studies have also demonstrated expression of PLZF in non-invariant CD1d-restricted T cells, as well as non-CD1d-restricted innate T cells. In humans, PLZF is expressed in NK cells, gamma delta T cells, as well as CD4 and CD8+ T cells. PLZF is also expressed in MR1-specific mucosal-associated invariant T cells, as well as in MHC Class II-restricted T cells that develop via a thymocyte-thymocyte interaction in humans. PLZF is expressed by innate lymphoid cells and its progenitor cells. PLZF exists as a homodimer or in complex with PLZP, and has been shown to be involved in the development of NKT cells, NK cell function, cellular quiescence, growth suppression, and maintenance of homeostatis. Finally, PLZF has been shown to inhibit gene expression induced by retinoic acid receptor.
Antibody clone number
9E12
Concentration
0.2 mg/mL
ZBTB16 protein structure - 25-9322-82 shown in red.