66281-1-Ig

antibody from Proteintech Group

Targeting: YY1 DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1

Provider product page for 66281-1-Ig

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Antigen structure
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Product number: 66281-1-Ig - Provider product page
Provider: Proteintech Group
Product name: YY1 antibody
Antibody type: Monoclonal
Description: YY1 antibody (Cat. #66281-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, monkey and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat, Simian
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2E11C5
Vial size: 150ul

YY1 protein structure - 66281-1-Ig shown in red.

Submitted references TGEV infection activates pro‑inflammatory signaling via the YY1/HSP40/NF‑κB pathway in intestinal epithelial cells and organoids.

Gao S, Chao Z, Cao Z, Wang F, Sun R, Liu G
Veterinary microbiology 2026 May;316:110985

EP300 attenuates ferroptosis and stimulates proliferation, migration, and fibrosis of keloid fibroblasts via YY1/GPX4 axis.

Jin J, Wang K, Lu C, Yao C, Xie F
Cell cycle (Georgetown, Tex.) 2026 Dec;25(1):1-16

A genome-wide analysis of YY1 and TFAP2 competition on overlapping motifs reveals their roles in HPV-induced carcinogenesis.

Liu Y, Ding S, Liu H
PLoS pathogens 2025 Sep;21(9):e1013524

PRODH2-Mediated Metabolism in the Bone Microenvironment Promotes Breast Cancer Metastasis.

Gong H, Li Y, Yang W, Xie Z, Hu J, Li P, Xu R, Li Y, Tao T, Li R, Liu S, Zhu Y, Song L, Fang L
Cancer research 2025 Nov 3;85(21):4198-4211

Targeting YY1-DR5 Axis by Pyripyropene O as a Novel Therapeutic Strategy Against Prostate Cancer: Molecular Mechanisms and In Vivo Zebrafish Validation.

Fang W, Chen Y, Nie M, Zhou X, Liu Y, Tao H, Yang B, Wang X
Marine drugs 2025 May 19;23(5)

A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans.

Ping J, Liu X, Lu Y, Quan C, Fan P, Lu H, Li Q, Wang C, Zhang Z, Liu M, Chen S, Chang L, Jiang Y, Huang Q, Liu J, Wuren T, Liu H, Hao Y, Kang L, Liu G, Lu H, Wei X, Wang Y, Li Y, Guo H, Cui Y, Zhang H, Zhang Y, Zhai Y, He Y, Zheng W, Qi X, Ouzhuluobu, Ma H, Yang L, Wang X, Jin W, Cui Y, Ge R, Wu S, Wei Y, Su B, He F, Zhang H, Zhou G
Cell genomics 2025 Mar 12;5(3):100782

NUF2 activated by YY1 promotes prostate cancer malignancy via p38/MAPK signaling axis and serves as a therapeutic target.

Jin C, Xu J, Luo W, Guo H, Ding L, Liu Y, Liu J, Zou L, Yu Y, Hao Y, Yang B
Biochemical pharmacology 2025 Jul;237:116919

SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation.

Xia S, Huo X, Liu N, Liu X, Wang T, Guo M, Zeng C, Wan P, Chen J
PLoS pathogens 2025 Jul;21(7):e1013344

Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology.

Quan X, Yi H, Huang M, Chen D
Mutation research 2025 Jul-Dec;831:111916

Transcriptional and post-translational mechanisms of ECM remodeling in rotator cuff tendons under hyperlipidemic conditions.

Rajalekshmi R, Agrawal DK
Life sciences 2025 Jul 1;372:123647

Transcriptomic Profiling Reveals Injury Responses of Peripheral Glial Cells in Sensory Neuron Microenvironment.

Xu J, Jin J, Lv S, Pan Y, Wang D, Shen N, Wang Y
Journal of neuroscience research 2025 Aug;103(8):e70072

Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis.

Wu C, Long L, Wang M, Shen L, Hu J, Tang H, Feng S, Liu X, Shi Y, Tang S, Chen Y
Communications biology 2025 Apr 24;8(1):658

DEAD/H-box helicase 11 is transcriptionally activated by Yin Yang-1 and accelerates oral squamous cell carcinoma progression.

Yang G, Shi X, Zhang M, Wang K, Tian X, Wang X
Cell biology international 2024 Nov;48(11):1731-1742

Celastrol induces DNA damage and cell death in BCR-ABL T315I-mutant CML by targeting YY1 and HMCES.

Yang F, Zhou H, Luo P, Jia L, Hou M, Huang J, Gao L, Zhang Q, Guan Y, Bao H, Zhang B, Liu L, Zou C, Yang Q, Wang J, Dai L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155937

Sirt6 Mono-ADP-Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission.

Zhang W, Bai L, Xu W, Liu J, Chen Y, Lin W, Lu H, Wang B, Luo B, Peng G, Zhang K, Shen C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2406390

YY1 downregulation underlies therapeutic response to molecular targeted agents.

Zhou S, Zang J, Cai MC, Ye K, Liu J, Ma P, Wu J, Dai C, Lu H, Zhang Q, Jiang J, Chu T, Shen Y, Tan L, Zhuang G, Zhao X, Wang L, Zhuang Y, Fu Y
Cell death & disease 2024 Nov 27;15(11):862

Oxymatrine Ameliorates Lupus Nephritis by Targeting the YY1-Mediated IL-6/STAT3 Axis.

Yuan H, Peng Z, Li H, Rao Y, Lu K, Yang C, Cheng C, Liu S
International journal of molecular sciences 2024 Nov 14;25(22)

YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes.

Huang J, Wang X, Li N, Fan W, Li X, Zhou Q, Liu J, Li W, Zhang Z, Liu X, Zeng S, Yang H, Tian M, Yang P, Hou S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(19):e2308031

The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis.

Shao ZY, Yang WD, Qiu H, He ZH, Lu MR, Shen Q, Ding J, Zheng JN, Bai J
Cell death & disease 2024 May 20;15(5):347

RPL35A drives ovarian cancer progression by promoting the binding of YY1 to CTCF promoter.

Wu H, Xia L, Sun L, Li D, Liu X, Song H, Sheng J, Wang K, Feng Q
Journal of cellular and molecular medicine 2024 Mar;28(6):e18115

Epstein-Barr virus protein EBNA-LP engages YY1 through leucine-rich motifs to promote naïve B cell transformation.

Cable JM, Reinoso-Vizcaino NM, White RE, Luftig MA
PLoS pathogens 2024 Jul;20(7):e1011950

Identification of mechanism of the oncogenic role of FGFR1 in papillary thyroid carcinoma.

Li XB, Li JL, Wang C, Zhang Y, Li J
European journal of histochemistry : EJH 2024 Jul 22;68(3)

Epstein-Barr virus protein EBNA-LP engages YY1 through leucine-rich motifs to promote naïve B cell transformation.

Cable JM, Reinoso-Vizcaino NM, White RE, Luftig MA
bioRxiv : the preprint server for biology 2024 Jan 8;

Discovery of Natural Ah Receptor Antagonists from Salvia miltiorrhiza Bunge and Synthesis of Analogs for Tumor Immunotherapy.

Li Z, Li S, Xing Z, Gu Q, Du R, Jiang J, Yuan X, Zhang X, Chen X, Xue N, Zhang P, Jin J, Yang Y
Journal of medicinal chemistry 2024 Jan 25;67(2):1243-1261

KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.

Zhang H, Xia T, Xia Z, Zhou H, Li Z, Wang W, Zhai X, Jin B
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96

MCRS1 sensitizes T cell-dependent immunotherapy by augmenting MHC-I expression in solid tumors.

Li X, Yi H, Jin Z, Jiang K, Xue K, Wang J, Qian Y, Xiang Q, Zhu S, Yan R, Yang Y, Sun S, Li K, Zhou Z, Yu W, Jiang N, Ding C, Lin X, Zhong J, Dong Y, Liu Y, Yu X
The Journal of experimental medicine 2024 Dec 2;221(12)

The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.

Yu S, Sun Z, Ju T, Liu Y, Mei Z, Wang C, Qu Z, Li N, Wu F, Liu K, Lu M, Huang M, Pang X, Jia Y, Li Y, Zhang Y, Dou S, Jiang J, Dong X, Huang C, Li W, Zhang Y, Yuan Y, Yang B, Du W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2308769

Activation of the YY1-UGT2B7 Axis Promotes Mammary Estrogen Homeostasis Dysregulation and Exacerbates Breast Tumor Metastasis.

Xu J, Zhou Y, He S, Wang Y, Ma J, Li C, Liu Z, Zhou X
Drug metabolism and disposition: the biological fate of chemicals 2024 Apr 16;52(5):408-421

YAP1 synergize with YY1 transcriptional co-repress DUSP1 to induce osimertinib resistant by activating the EGFR/MAPK pathway and abrogating autophagy in non-small cell lung cancer.

Ning Y, Zheng H, Yang Y, Zang H, Wang W, Zhan Y, Wang H, Luo J, Wen Q, Peng J, Xiang J, Fan S
International journal of biological sciences 2023;19(8):2458-2474

AKIP1 accelerates glioblastoma progression through stabilizing EGFR expression.

Wan S, Liu C, Li C, Wang Z, Zhao G, Li J, Ran W, Zhong X, Li Y, Zhang L, Cui H
Oncogene 2023 Sep;42(39):2905-2918

Rac GTPase activating protein 1 promotes the glioma growth by regulating the expression of MCM3.

Jia B, Jiang Y, Huan Y, Han Y, Liu W, Liu X, Wang Y, He L, Cao Z, He X, Zhang K, Gu J, Guo Q, Fei Z
Translational oncology 2023 Nov;37:101756

Long non‑coding RNA BLACAT2/miR‑378a‑3p/YY1 feedback loop promotes the proliferation, migration and invasion of uterine corpus endometrial carcinoma.

Zhang C, Wang R, Li M, Yang Q
Oncology reports 2023 May;49(5)

METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.

Wei W, Zhang ZY, Shi B, Cai Y, Zhang HS, Sun CL, Fei YF, Zhong W, Zhang S, Wang C, He B, Jiang GM, Wang H
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151

Silencing of microRNA-106b-5p prevents doxorubicin-mediated cardiotoxicity through modulation of the PR55α/YY1/sST2 signaling axis.

Lax A, Soler F, Fernandez Del Palacio MJ, Pascual-Oliver S, Ballester MR, Fuster JJ, Pascual-Figal D, Asensio-Lopez MDC
Molecular therapy. Nucleic acids 2023 Jun 13;32:704-720

A T(reg)-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver.

Ding C, Yu Z, Sefik E, Zhou J, Kaffe E, Wang G, Li B, Flavell RA, Hu W, Ye Y, Li HB
Nature aging 2023 Jul;3(7):813-828

PGC7 regulates H3K27me3 modification by inhibiting the interaction of YY1 with PRC2.

Hao W, Huang C, Liu D, Xu H, Liu Y, Guan Y, Chen B, Guo Z
American journal of physiology. Cell physiology 2023 Jul 1;325(1):C286-C299

LINC01608 activated by YY1 facilitate hepatocellular carcinoma progression by modulating the EGFR/ERK axis.

Han M, Liu F, Li X, Zhang H, Pan Y, Liu Y, Zhu H, Liang H, Chen X, Liao Z, Zhang Z, Zhang B
Liver international : official journal of the International Association for the Study of the Liver 2023 Feb;43(2):471-489

Mechanism of YY1 mediating autophagy dependent ferroptosis in PM2.5 induced cardiac fibrosis.

Hu H, Li L, Zhang H, Zhang Y, Liu Q, Chen M, Ning J, Pang Y, Hu W, Niu Y, Zhang R
Chemosphere 2023 Feb;315:137749

Atractylodes lancea volatile oils target ADAR2-miR-181a-5p signaling to mesenchymal stem cell chondrogenic differentiation.

Ye S, Si W, Qin W, Yang L, Luo Z, Li Z, Xie Y, Pan H, Li X, Huang Z, Zhu M, Chen D
Anatomical record (Hoboken, N.J. : 2007) 2023 Dec;306(12):3006-3020

SP1-Induced Upregulation of LncRNA AFAP1-AS1 Promotes Tumor Progression in Triple-Negative Breast Cancer by Regulating mTOR Pathway.

Li F, Xian D, Huang J, Nie L, Xie T, Sun Q, Zhang X, Zhou Y
International journal of molecular sciences 2023 Aug 29;24(17)

Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.

Li MX, Wu XT, Jing WQ, Hou WK, Hu S, Yan W
Cell death & disease 2023 Aug 2;14(8):492

YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2.

Wang X, Fan W, Li N, Ma Y, Yao M, Wang G, He S, Li W, Tan J, Lu Q, Hou S
Genome biology 2023 Apr 21;24(1):87

YY1 promotes pancreatic cancer cell proliferation by enhancing mitochondrial respiration.

Li B, Wang J, Liao J, Wu M, Yuan X, Fang H, Shen L, Jiang M
Cancer cell international 2022 Sep 19;22(1):287

Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway.

Zhou S, Li P, Qin L, Huang S, Dang N
Experimental dermatology 2022 Oct;31(10):1563-1578

Knockdown of YY1 Inhibits XIST Expression and Enhances Cloned Pig Embryo Development.

Dong Y, Wu X, Peng X, Yang L, Tan B, Zhao H, Zheng E, Hong L, Cai G, Wu Z, Li Z
International journal of molecular sciences 2022 Nov 23;23(23)

Stabilization but No Functional Influence of HIF-1α Expression in the Intestinal Epithelium during Salmonella Typhimurium Infection.

Robrahn L, Dupont A, Jumpertz S, Zhang K, Holland CH, Guillaume J, Rappold S, Roth J, Cerovic V, Saez-Rodriguez J, Hornef MW, Cramer T
Infection and immunity 2022 Feb 17;90(2):e0022221

RNF144A exerts tumor suppressor function in breast cancer through targeting YY1 for proteasomal degradation to downregulate GMFG expression.

Zhang YL, Cao JL, Zhang Y, Liao L, Deng L, Yang SY, Hu SY, Ning Y, Zhang FL, Li DQ
Medical oncology (Northwood, London, England) 2022 Feb 1;39(4):48

YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway.

Li W, Ye K, Li X, Liu X, Peng M, Chen F, Xiong W, Wang Y, Zhu L
Journal of experimental & clinical cancer research : CR 2022 Aug 17;41(1):250

Long noncoding RNA LINC01435 impedes diabetic wound healing by facilitating YY1-mediated HDAC8 expression.

Fu W, Liang D, Wu X, Chen H, Hong X, Wang J, Zhu T, Zeng T, Lin W, Chen S, Yan L, Ren M
iScience 2022 Apr 15;25(4):104006

YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling.

Mei C, Jiang X, Gu Y, Wu X, Ma W, Chen X, Wang G, Yao Y, Liu Y, Zhang Z, Yuan Y
American journal of cancer research 2021;11(5):2238-2251

Prenatal dexamethasone exposure induces nonalcoholic fatty liver disease in male rat offspring via the miR-122/YY1/ACE2-MAS1 pathway.

Liu H, He B, Hu W, Liu K, Dai Y, Zhang D, Wang H
Biochemical pharmacology 2021 Mar;185:114420

Angiotensin II-induced muscle atrophy via PPARγ suppression is mediated by miR-29b.

Li J, Yang T, Sha Z, Tang H, Hua X, Wang L, Wang Z, Gao Z, Sluijter JPG, Rowe GC, Das S, Yang L, Xiao J
Molecular therapy. Nucleic acids 2021 Mar 5;23:743-756

Transcription factor YY1 enhances the stemness of lung cancer cells by stabilizing hypoxia factor HIF-1α under a hypoxic microenvironment.

Huang X, Zhou W, Zhang Y
Environmental toxicology 2021 Jan;36(1):114-122

Acinetobacter baumannii up-regulates LncRNA-GAS5 and promotes the degradation of STX17 by blocking the activation of YY1.

An Z, Ding W
Virulence 2021 Dec;12(1):1965-1979

Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression.

Liu C, Qu J, Wu M, Huang X, Li L
Ecotoxicology and environmental safety 2021 Dec 1;225:112792

Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis.

Dong X, Kwan KM
Molecular brain 2020 Jul 23;13(1):104

MiR-302b as a Combinatorial Therapeutic Approach to Improve Cisplatin Chemotherapy Efficacy in Human Triple-Negative Breast Cancer.

Cataldo A, Romero-Cordoba S, Plantamura I, Cosentino G, Hidalgo-Miranda A, Tagliabue E, Iorio MV
Cancers 2020 Aug 12;12(8)

FAM3C-YY1 axis is essential for TGFβ-promoted proliferation and migration of human breast cancer MDA-MB-231 cells via the activation of HSF1.

Yang W, Feng B, Meng Y, Wang J, Geng B, Cui Q, Zhang H, Yang Y, Yang J
Journal of cellular and molecular medicine 2019 May;23(5):3464-3475

Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription.

Xiao R, Chen JY, Liang Z, Luo D, Chen G, Lu ZJ, Chen Y, Zhou B, Li H, Du X, Yang Y, San M, Wei X, Liu W, Lécuyer E, Graveley BR, Yeo GW, Burge CB, Zhang MQ, Zhou Y, Fu XD
Cell 2019 Jun 27;178(1):107-121.e18

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

Tang W, Zhou W, Xiang L, Wu X, Zhang P, Wang J, Liu G, Zhang W, Peng Y, Huang X, Cai J, Bai Y, Bai L, Zhu W, Gu H, Xiong J, Ye C, Li A, Liu S, Wang J
Nature communications 2019 Feb 8;10(1):663

CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p.

Rong D, Lu C, Zhang B, Fu K, Zhao S, Tang W, Cao H
Molecular cancer 2019 Feb 18;18(1):25

hnRNPM, a potential mediator of YY1 in promoting the epithelial-mesenchymal transition of prostate cancer cells.

Yang T, An Z, Zhang C, Wang Z, Wang X, Liu Y, Du E, Liu R, Zhang Z, Xu Y
The Prostate 2019 Aug;79(11):1199-1210

CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7.

Zeng K, Chen X, Xu M, Liu X, Hu X, Xu T, Sun H, Pan Y, He B, Wang S
Cell death & disease 2018 Apr 1;9(4):417

miR-29b contributes to multiple types of muscle atrophy.

Li J, Chan MC, Yu Y, Bei Y, Chen P, Zhou Q, Cheng L, Chen L, Ziegler O, Rowe GC, Das S, Xiao J
Nature communications 2017 May 25;8:15201

MicroRNA-29a promotes smooth muscle cell differentiation from stem cells by targeting YY1.

Jin M, Wu Y, Wang Y, Yu D, Yang M, Yang F, Feng C, Chen T
Stem cell research 2016 Sep;17(2):277-284

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