22156-1-AP

antibody from Proteintech Group

Targeting: YY1 DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1

Provider product page for 22156-1-AP

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Immunocytochemistry

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [56]
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Validations
Western blot [1]

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Product number: 22156-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#22156-1-AP, RRID:AB_11182932
Product name: YY1 antibody
Antibody type: Polyclonal
Description: KD/KO validated YY1 antibody (Cat. #22156-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 150ul

YY1 protein structure - 22156-1-AP shown in red.

Submitted references DLD, upregulated by YY1, fuels glioblastoma multiforme progression via EphA2 phosphorylation to activate PI3K/AKT/mTOR.

Tang G, Zhou Y, Su J, Yuan M, You J, Huang W, Li H, Zhao Z
QJM : monthly journal of the Association of Physicians 2026 Mar 9;

YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy.

Chai J, Han L, Mo D, Bai Y, Yang Y, Ding Y, Chen S, Kong X, Zhu X, Xu L, Dai H, Wang W
Redox biology 2026 Apr;91:104085

The Effects and Mechanisms of the YY1/EGFR Axis on Inflammation and Oxidative Stress in Asthma.

Li Y, Li P, Jiang T, Wu R, Wang Y, Cheng Z
Cell biochemistry and biophysics 2025 Sep;83(3):3571-3580

YY1-Upregulated MTHFD2 Drives Non-Small Cell Lung Cancer Progression Through the Regulation of LRRK2.

Wei Z, Liu J, Luan X, Gu C
Journal of biochemical and molecular toxicology 2025 Sep;39(9):e70504

Hypoxia-induced tumor cell-intrinsic PLAU activation drives immunotherapy resistance in collagenic lung adenocarcinoma.

Wan L, Ma T, Li B, Shi X, Chen S, Sun X, Ge H, Lu C, Yu W, Zhou N, Xu Y, Ma L, Wang Z
International immunopharmacology 2025 Sep 23;162:115161

Dissecting the Single-Cell Diversity and Heterogeneity Underlying Cervical Precancerous Lesions and Cancer Tissues.

Han Y, Shi L, Jiang N, Huang J, Jia X, Zhu B
Reproductive sciences (Thousand Oaks, Calif.) 2025 May;32(5):1502-1519

Tributyltin affects the growth of ovarian granulosa cells in polycystic ovary syndrome by upregulating YY1-mediated CDKN1C via the PI3K/AKT pathway.

Dong S, Liu Y, Yang Z
Reproductive biology 2025 Jun;25(2):101020

A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1.

Xu W, Yi J, Wei X, Wang M, Zhao M, Zhao M, Wang X, Shen Y, Wang Z, Jin S
Journal of translational medicine 2025 Jun 4;23(1):629

YY1/HIF-1α/mROS positive-feedback loop exacerbates glomerular mesangial cell proliferation in mouse early diabetic kidney disease.

Yang TT, Shao YT, Cheng Q, He YT, Qiu Z, Pan DD, Zhang HM, Jiang ZZ, Yan M, Ying CJ, Li BJ, Liu JJ, Qian ST, Wang T, Yin XX, Lu Q
Acta pharmacologica Sinica 2025 Jul;46(7):1974-1989

Pyrroloquinoline Quinone Reprograms the Single-Cell Landscape of Immune Aging in Hematopoietic Immune System.

Liu X, Zhang C, Lv J, Liu Y, Gu C, Gao Y, Ding W, Chen H, Xu N, Yin H, Su W, Xu Z
Aging cell 2025 Jul;24(7):e70050

Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology.

Quan X, Yi H, Huang M, Chen D
Mutation research 2025 Jul-Dec;831:111916

LPS mediates cuproptosis and inflammation in THP-1 macrophages through HKDC1.

Ou L, Meng Z, Mei J, Yuan H, Zhu X, Wang X, Shen A, Wang Z, Zhang L, Wang S, Chen Y, Pang X, Liu Y, Xu Y, Ma C
Acta biochimica et biophysica Sinica 2025 Jul 22;57(12):1953-68

Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice.

Mayerl S, Martin AA, Bauer R, Heuer H
European thyroid journal 2025 Feb 1;14(1)

Hydroxychloroquine cures autoimmune myocarditis by inhibiting the innate immune system via the C-X-C motif chemokine ligand 16 and C-X-C motif receptor 6 axis between macrophages and T cells.

Xuan Y, Gao X, Wang J, Li H, Zhou Z, Liao M, Wen Z, Wang DW
British journal of pharmacology 2025 Aug;182(15):3649-3668

FBRSL1 regulates the expression of chromatin regulators BRPF1 and KAT6A.

Kastens G, Berger-Santangelo H, Gerstner S, Ufartes R, Mischak M, Borchers A, Pauli S
Human genetics 2025 Aug;144(8):809-826

FBXO42 promotes hepatocellular carcinoma progression via mediating p57Kip2 ubiquitination and degradation.

Zhou B, Wu S, Hong S, Li H, Jiang Z, Sun Y, Qiu J, Qin L
European journal of medical research 2025 Aug 21;30(1):784

Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5.

Chen ZS, Peng SI, Leong LI, Gall-Duncan T, Wong NSJ, Li TH, Lin X, Wei Y, Koon AC, Huang J, Sun JK, Turner C, Tippett L, Curtis MA, Faull RLM, Kwan KM, Chow HM, Ko H, Chan TF, Talbot K, Pearson CE, Chan HYE
Nature communications 2025 Apr 9;16(1):3307

Picroside Ⅱ alleviates renal fibrosis through YY1-dependent transcriptional inhibition of TGFβ1.

Zhang X, Zhang J, Xu X, Chen S, Gao F
Metabolism open 2024 Sep;23:100316

Jujuboside A through YY1/CYP2E1 signaling alleviated type 2 diabetes-associated fatty liver disease by ameliorating hepatic lipid accumulation, inflammation, and oxidative stress.

Zhang W, Cheng Q, Yin L, Liu Y, Chen L, Jiang Z, Jiang X, Qian S, Li B, Wu M, Yin X, Wang T, Lu Q, Yang T
Chemico-biological interactions 2024 Sep 1;400:111157

Sirt6 Mono-ADP-Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission.

Zhang W, Bai L, Xu W, Liu J, Chen Y, Lin W, Lu H, Wang B, Luo B, Peng G, Zhang K, Shen C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2406390

The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis.

Shao ZY, Yang WD, Qiu H, He ZH, Lu MR, Shen Q, Ding J, Zheng JN, Bai J
Cell death & disease 2024 May 20;15(5):347

Mitochondrial ribosomal protein L12 potentiates hepatocellular carcinoma by regulating mitochondrial biogenesis and metabolic reprogramming.

Ji X, Yang Z, Li C, Zhu S, Zhang Y, Xue F, Sun S, Fu T, Ding C, Liu Y, Wan Q
Metabolism: clinical and experimental 2024 Mar;152:155761

Role and mechanism of COL3A1 in regulating the growth, metastasis, and drug sensitivity in cisplatin-resistant non-small cell lung cancer cells.

Ren J, Zhao S, Lai J
Cancer biology & therapy 2024 Dec 31;25(1):2328382

GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling.

Huang S, Liu J, Hu J, Hou Y, Hu M, Zhang B, Luo H, Fu S, Chen Y, Liu X, Chen Z, Wang L
Journal of cellular and molecular medicine 2024 Apr;28(8):e18290

METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.

Wang J, Yin H, Li G, Wu D, Xu Y, Chen Y, Wang X, Xing Y, Zhang T, Fei D, Yang P, Fang F, Tao Y, Li X, Yu J, Yang Y, Li Z, Shi L, Zhang Z, Pan J
Cell death discovery 2024 Apr 22;10(1):186

Targeting mTOR/YY1 signaling pathway by quercetin through CYP7A1-mediated cholesterol-to-bile acids conversion alleviated type 2 diabetes mellitus induced hepatic lipid accumulation.

Yang T, Wang Y, Cao X, Peng Y, Huang J, Chen L, Pang J, Jiang Z, Qian S, Liu Y, Ying C, Wang T, Zhang F, Lu Q, Yin X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154703

Salt-like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin-specific protease 21 to stabilize Yin Yang 1.

Wang QD, Liu LL, Li D, Gao L, Zhang MJ
Pathology international 2023 Mar;73(3):109-119

Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development.

Sakamoto M, Abe S, Miki Y, Miyanari Y, Sasaki H, Ishiuchi T
Genes & development 2023 Jul 1;37(13-14):590-604

LINC01608 activated by YY1 facilitate hepatocellular carcinoma progression by modulating the EGFR/ERK axis.

Han M, Liu F, Li X, Zhang H, Pan Y, Liu Y, Zhu H, Liang H, Chen X, Liao Z, Zhang Z, Zhang B
Liver international : official journal of the International Association for the Study of the Liver 2023 Feb;43(2):471-489

Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD.

Chen ZS, Ou M, Taylor S, Dafinca R, Peng SI, Talbot K, Chan HYE
Nature communications 2023 Dec 18;14(1):8420

YY1 Binding to Regulatory Elements That Lack Enhancer Activity Promotes Locus Folding and Gene Activation.

Gao Z, Wang M, Smith A, Boyes J
Journal of molecular biology 2023 Dec 1;435(23):168315

RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis.

Yao H, Zhang S, Xie H, Fan Y, Miao M, Zhu R, Yuan L, Gu M, You Y, You B
Cellular oncology (Dordrecht, Netherlands) 2023 Aug;46(4):1031-1048

PARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum stress in granulosa cells to determine primordial follicle activation.

Chen W, E Q, Sun B, Zhang P, Li N, Fei S, Wang Y, Liu S, Liu X, Zhang X
Cell death & disease 2023 Aug 15;14(8):524

Enterobacterial LPS-inducible LINC00152 is regulated by histone lactylation and promotes cancer cells invasion and migration.

Wang J, Liu Z, Xu Y, Wang Y, Wang F, Zhang Q, Ni C, Zhen Y, Xu R, Liu Q, Fang W, Huang P, Liu X
Frontiers in cellular and infection microbiology 2022;12:913815

CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation.

Si M, Song Y, Wang X, Wang D, Liu X, Qu X, Song Z, Yu X
Cell & bioscience 2022 Oct 9;12(1):171

Supplementation of SDF1 during Pig Oocyte In Vitro Maturation Improves Subsequent Embryo Development.

Zhao H, Dong Y, Zhang Y, Wu X, Zhang X, Liang Y, Li Y, Zeng F, Shi J, Zhou R, Hong L, Cai G, Wu Z, Li Z
Molecules (Basel, Switzerland) 2022 Oct 12;27(20)

Valproic acid upregulates sodium-dependent vitamin C transporter-2 functional expression in neuronal cells.

Teafatiller T, Subramanian S, Marquez FE, Kitazawa M, Subramanian VS
Life sciences 2022 Nov 1;308:120944

HPV8 Reverses the Transcriptional Output in Lrig1 Positive Cells to Drive Skin Tumorigenesis.

Syed AS, Marcuzzi GP, Miller-Lazic D, Hess J, Hufbauer M, Akgül B
Cancers 2022 Mar 25;14(7)

Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis.

Xu W, He C, Kaye EG, Li J, Mu M, Nelson GM, Dong L, Wang J, Wu F, Shi YG, Adelman K, Lan F, Shi Y, Shen H
Molecular cell 2022 Mar 17;82(6):1156-1168.e7

MORTALIN-Ca(2+) axis drives innate rituximab resistance in diffuse large B-cell lymphoma.

Sun Q, Ye Y, Gui A, Sun X, Xie S, Zhan Y, Chen R, Yan Y, Gu J, Qiu S, Liu W, Zuo J, Zhang Q, Yang L
Cancer letters 2022 Jul 1;537:215678

Effect of Promoter Methylation on the Expression of Porcine MUC2 Gene and Resistance to PEDV Infection.

Xiao Y, Zhou Y, Sun S, Wang H, Wu S, Bao W
Frontiers in veterinary science 2021;8:646408

YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis.

Zhang T, Beeharry MK, Wang Z, Zhu Z, Li J, Li C
International journal of biological sciences 2021;17(7):1629-1643

KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.

Zhang C, Shen L, Zhu Y, Xu R, Deng Z, Liu X, Ding Y, Wang C, Shi Y, Bei L, Wei D, Thorne RF, Zhang XD, Yu L, Chen S
Theranostics 2021;11(6):2691-2705

PTIP Inhibits Cell Invasion in Esophageal Squamous Cell Carcinoma via Modulation of EphA2 Expression.

Han X, Zhu Y, Shen L, Zhou Y, Pang L, Zhou W, Gu H, Han K, Yang Y, Jiang C, Xie J, Zhang C, Ding L
Frontiers in oncology 2021;11:629916

Long non-coding RNA Xist regulates oocyte loss via suppressing miR-23b-3p/miR-29a-3p maturation and upregulating STX17 in perinatal mouse ovaries.

Zhou M, Liu X, Qiukai E, Shang Y, Zhang X, Liu S, Zhang X
Cell death & disease 2021 May 25;12(6):540

Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.

Gao C, Jia W, Xu W, Wu Q, Wu J
Journal of neuroinflammation 2021 May 22;18(1):118

Asymmetrical arginine dimethylation of histone H4 by 8-oxog/OGG1/PRMT1 is essential for oxidative stress-induced transcription activation.

Wang W, Ma Y, Huang M, Liang W, Zhao X, Li Q, Wang S, Hu Z, He L, Gao T, Chen J, Pan F, Guo Z
Free radical biology & medicine 2021 Feb 20;164:175-186

LncRNA NEAT1 Targets Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via the miR-410-3p/YY1 Axis.

Wang Y, Hou L, Yuan X, Xu N, Zhao S, Yang L, Zhang N
Frontiers in immunology 2020;11:1975

miR-431-5p regulates cell proliferation and apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis by targeting XIAP.

Wang Y, Zhang K, Yuan X, Xu N, Zhao S, Hou L, Yang L, Zhang N
Arthritis research & therapy 2020 Oct 6;22(1):231

Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1.

Gao P, Li L, Yang L, Gui D, Zhang J, Han J, Wang J, Wang N, Lu J, Chen S, Hou L, Sun H, Xie L, Zhou J, Peng C, Lu Y, Peng X, Wang C, Miao J, Ozcan U, Huang Y, Jia W, Liu J
Science translational medicine 2019 Sep 18;11(510)

Heat shock cognate protein 70 promotes the differentiation of C2C12 myoblast and targets Yin Yang 1.

Chen L, Guo T, Yu Y, Sun Y, Yu G, Cheng L
Annals of translational medicine 2019 Oct;7(20):551

YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.

Shen X, Zhong J, Yu P, Zhao Q, Huang T
Biochemical and biophysical research communications 2019 Feb 5;509(2):448-454

A haplotype variant of Hu sheep follicle-stimulating hormone receptor promoter region decreases transcriptional activity.

Du X, Guo J, Cao QY, Yao W, Li QF
Animal genetics 2019 Aug;50(4):407-411

Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer.

Huang Y, Tao T, Liu C, Guan H, Zhang G, Ling Z, Zhang L, Lu K, Chen S, Xu B, Chen M
International journal of oncology 2017 Feb;50(2):421-431

Changes in MicroRNA Expression During Maturation of the Bovine Corpus Luteum: Regulation of Luteal Cell Proliferation and Function by MicroRNA-34a.

Maalouf SW, Smith CL, Pate JL
Biology of reproduction 2016 Mar;94(3):71

Interleukin-18 Down-Regulates Multidrug Resistance-Associated Protein 2 Expression through Farnesoid X Receptor Associated with Nuclear Factor Kappa B and Yin Yang 1 in Human Hepatoma HepG2 Cells.

Liu XC, Lian W, Zhang LJ, Feng XC, Gao Y, Li SX, Liu C, Cheng Y, Yang L, Wang XJ, Chen L, Wang RQ, Chai J, Chen WS
PloS one 2015;10(8):e0136215

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The YY1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human YY1. This antibody recognizes human antigen. The YY1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 22156-1-AP.pdf

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