HPA001119

antibody from Atlas Antibodies

Targeting: YY1 DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Chromatin Immunoprecipitation (Supportive data in Antibodypedia)

Antibody Data

Product number

HPA001119

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA001119, RRID:AB_1858930

Product name

Anti-YY1

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human YY1, Gene description: YY1 transcription factor, Alternative Gene Names: DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, Validated applications: ChIP, IHC, WB, Uniprot ID: P25490, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.1 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer

Xu C, Tsai Y, Galbo P, Gong W, Storey A, Xu Y, Byrum S, Xu L, Whang Y, Parker J, Mackintosh S, Edmondson R, Tackett A, Huang J, Zheng D, Earp H, Wang G, Cai L
Nucleic Acids Research 2021;49(9):4971-4988

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Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer

Patten D, Corleone G, Győrffy B, Perone Y, Slaven N, Barozzi I, Erdős E, Saiakhova A, Goddard K, Vingiani A, Shousha S, Pongor L, Hadjiminas D, Schiavon G, Barry P, Palmieri C, Coombes R, Scacheri P, Pruneri G, Magnani L
Nature Medicine 2018;24(9):1469-1480

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Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication

Kaufhold S, Garbán H, Bonavida B
Journal of Experimental & Clinical Cancer Research 2016;35(1)

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Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma

Bevelacqua V, Bevelacqua Y, Candido S, Skarmoutsou E, Amoroso A, Guarneri C, Strazzanti A, Gangemi P, Mazzarino M, D’Amico F, McCubrey J, Libra M, Malaponte G
Oncotarget 2012;3(8):882-892

Chromatin Immunoprecipitation

Supportive validation

Submitted by

Atlas Antibodies (provider)

Main image

Experimental details

ChIP-Exo-Seq composite graph for Anti-YY1 (HPA001119, Lot B115417) tested in K562 cells. Strand-specific reads (blue: forward, red: reverse) and IgG controls (black: forward, grey: reverse) are plotted against the distance from a composite set of reference binding sites. The antibody exhibits robust target enrichment compared to a non-specific IgG control and precisely reveals its structural organization around the binding site. Data generated by Prof. B. F. Pugh´s Lab at Cornell University.