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- Antigen structure
- References [4]
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- Product number
- 14-9962-82 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- FOXP1 Monoclonal Antibody (JC12 (JC-12)), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This JC12 monoclonal antibody reacts with human Foxp1, a member of the Forkhead family of winged helix transcription factors. Foxp1 is expressed in nearly every human tissue, including lymphoid (e.g. tonsil, spleen, and thymus), epithelium, kidney, blood, and motor neurons. Altered Foxp1 expression has been observed in, among others, cancers of the breast, lung, colon, prostate, and pancreas. Moreover, patients with diffuse large B cell lymphomas express high levels of Foxp1, which can be utilized as a prognostic marker for survival. Finally, Foxp1 has been reported to be involved in early B cell development (i.e. pro-B cell to pre-B cell transition) and motor neuron specification and connectivity.
- Antibody clone number
- JC12 (JC-12)
- Concentration
- 0.5 mg/mL
Submitted references FoxP1: conducting the Hox symphony in spinal motor neurons.
Foxp1 is an essential transcriptional regulator of B cell development.
Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma.
The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.
Arber S
Nature neuroscience 2008 Oct;11(10):1122-4
Nature neuroscience 2008 Oct;11(10):1122-4
Foxp1 is an essential transcriptional regulator of B cell development.
Hu H, Wang B, Borde M, Nardone J, Maika S, Allred L, Tucker PW, Rao A
Nature immunology 2006 Aug;7(8):819-26
Nature immunology 2006 Aug;7(8):819-26
Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma.
Banham AH, Connors JM, Brown PJ, Cordell JL, Ott G, Sreenivasan G, Farinha P, Horsman DE, Gascoyne RD
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Feb 1;11(3):1065-72
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Feb 1;11(3):1065-72
The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.
Banham AH, Beasley N, Campo E, Fernandez PL, Fidler C, Gatter K, Jones M, Mason DY, Prime JE, Trougouboff P, Wood K, Cordell JL
Cancer research 2001 Dec 15;61(24):8820-9
Cancer research 2001 Dec 15;61(24):8820-9
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Immunoblotting of lysates prepared from Jurkat cells with 5 µg/mL Anti-Human Foxp1 Purified.Bands were visualized using Anti-Mouse IgG HRP.
