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- Product number
- 16396-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16396-1-AP, RRID:AB_2782956
- Product name
- NRF2, NFE2L2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NRF2, NFE2L2 antibody (Cat. #16396-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references β-Cryptoxanthin Confers Radioprotection against Intestinal Injury via NRF2-Mediated Antioxidant Response and Gut Microbiota Reprogramming.
Identification of autophagy-related key biomarkers in caerulein induced acute pancreatitis: In silico and in vivo study.
SHP2 improved Late-onset fetal growth restriction via modulating ROS/BRD4/PI3K/YAP/PIGF signaling induced angiogenesis.
Combined polyphenols in Psidium guajava-citrus limon leaf extract attenuate fructose-induced cardiac injury by modulating metabolic and oxidative stress pathways in rats.
Bioinformatic Identification and Preliminary Validation of TP53, TGFB1, and NFE2L2 as Potential Ferroptosis-Related Regulators in Pancreatic Adenocarcinoma.
Cinnamaldehyde attenuates LPS-induced acute kidney injury by inhibiting ferroptosis via the Gsk3β/Nrf2/Gpx4 pathway.
Akkermansia muciniphila alleviates antibiotic- and LPS-induced oxidative stress via the p38α MAPK-Nrf2 signaling axis.
Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury.
SMURF2 attenuates NRF2-driven tumor progression by acting as a nuclear brake on NRF2 during cellular stress.
Asperuloside-Mediated Activation of Nrf2 Inhibits the NF-κB Pathway and Suppresses Osteoarthritis Progression.
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Luteoloside attenuates renal Ischemia-Reperfusion injury by suppressing ferroptosis through disruption of the KEAP1-NRF2 interaction.
Indole-3-carbinol attenuates cisplatin-induced premature ovarian failure by activating Nrf2 through competitive binding of Keap1.
g-C(3)N(4) Nanosheets as a Ferroptosis-Targeted Nanoprobe: Mitigating Iron Overload and Restoring Male Fertility via Nrf2 Pathway Activation.
Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2/ROS/NLRP3 axis and modulation of the gut microbiota.
NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way.
Prenylterphenyllin, a regulator of P53, inhibits colorectal cancer progression through oxidative stress and energy metabolism pathway.
Ciliary IFT88 inhibits intervertebral disc degeneration under excessive mechanical stress by regulating endplate cartilage calcification.
Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation.
Cell-penetrating peptide-functionalized biomimetic nanovesicles for efficient cataract treatment via enhanced corneal penetration and lens-mitochondria dual targeting.
Differential regulation of radioadaptation by quercetin between human normal and cancer cells.
Concurrent Ferroptosis and Apoptosis in Resveratrol-Treated Glioblastoma Cells: Relevance With NRF2 Downregulation and Oxidative Stress.
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis.
Amygdalin synergizes with the TNF-α monoclonal antibody infliximab to modulate HSP90 and related necro-inflammatory/oxidative stress pathways in a rat model of hepatic I/R.
Role of connexin32 in zinc oxide nanoparticles induced hepatotoxicity.
Faecalibacterium prausnitzii suppresses ovarian cancer by inducing ferroptosis via phenylalanine metabolism activation.
MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment.
Astaxanthin alleviates DSS-induced ulcerative colitis in mice associated with Nrf2-mediated ferroptosis independently of gut microbiota modulation.
Traditional Chinese Herbal Formula XuMingZhuSan Alleviates Neuronal Ferroptosis in Rats After Stroke by Activating the NRF2/GPX4/SLC7A11 Pathway.
Cascade Therapy of Periodontitis via Sequential Release of Ribosome-Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF-Based System.
ANO6 Confers Paclitaxel Resistance by Targeting Ferroptosis in Cervical Cancer.
Targeting the FTO-ACSL4 Pathway: A Novel Mechanism for Sanguinarine Chloride-Induced Ferroptosis in Endometrial Cancer.
Anti-Inflammatory Effects of Curcumin via the Nrf2-cGAS-STING-NF-κB Pathway in MH7A Rheumatoid Arthritis Fibroblast-like Synoviocytes.
Boron Triggers Hepatic Ferroptosis: Unveiling the Dual-Pathogenic Nexus of Oxidative Stress and SLC7A11/GPX4 Dysregulation.
Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis.
MyD88 inhibitory Peptide-2 (MIP2) improves neurological outcomes and reduces neuroinflammation after intracerebral Hemorrhage-mediated secondary brain injury.
High-Intensity Interval Training Outperforms Moderate-Intensity Exercise in Hyperlipidemic ApoE⁻/⁻ Mice: A Molecular and Histological Comparison.
USP1 promotes hepatocellular carcinoma progression by modulating mitophagy via stabilizing MCM3 to regulate the Keap1-Nrf2 axis.
Retinoic Acid Alleviates TGEV-Induced Ferroptosis by Activating the p62-NRF2-GPX4/HO-1 Pathway and Iron Metabolism in Intestinal Epithelial Cells.
EGCG Derivatives Alleviate Diquat-Induced Liver and Gut Damage in Mice by Activating an Antioxidant Pathway and Enhancing Barrier Function.
NUAK1 silencing enhances radiotherapy-induced ferroptosis in locally advanced rectal cancer by impairing Nrf2-driven transcription of GPX4.
CXCL12 Promotes Peripheral Nerve Injury Repair by Inhibiting the Ferroptosis-Inflammation Axis via the ERK/Nrf2 Pathway.
NRF2 deficiency impairs proliferation and survival of chicken primordial germ cells via oxidative stress, mitochondrial dysfunction and apoptosis.
Bellidifolin mitigates doxorubicin-induced myocardial injury via regulating oxidative stress, inflammation, and apoptosis: a combination of network pharmacology and experiments.
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
Ethanol extract of Gastrodia elata Blume alleviates ischemic stroke by inhibiting oxidative stress and ferroptosis through the PI3K/AKT/Nrf2 pathway.
A spinal USP7-Bach1 positive feedback loop drives NOX4-mediated ferroptosis in neuropathic pain.
A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway.
Class Effect of SGLT2 Inhibitors Against Doxorubicin-Induced Cardiotoxicity via Regulating Adenosine Kinase Mediated-Cardiac Oxidative Stress.
Protean bio-heterojunction nanoparticle coating for dynamically modulating diabetic microenvironment.
Dietary Zanthoxylum bungeanum leaves supplementation enhances antioxidant capacity through activation of Nrf2 signalling pathway in pigs.
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Extracellular histone H3 induces METosis in acute liver failure by regulating the NRF2/HO-1/NQO1 pathway-mediated oxidative stress.
Farrerol mitigates fungal keratitis by enhancing fungal clearance and limiting inflammation through autophagy and Nrf2 pathway.
The Berberine Derivative BBR684 Inhibits VDAC Oligomerization to Suppress Ferroptosis in Acute Kidney Injury.
Immune-epithelial dual-targeting bilirubin nanoparticles for acute lung injury.
A multimodal ROS logic-gated therapeutic platform disrupts the vicious cycle of senescence to promote aged bone defect repair.
ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucleus pulposus cells.
NRF2/SLC7A11 axis-mediated metabolic reprogramming drives Benzo[a]pyrene-induced malignant transformation: Evidence from lung organoid and 16HBE cell models.
Dimethyl fumarate alleviates oxidative stress and inflammation in noise-induced hearing loss by activating Nrf2/HO-1 signaling in cochlear hair cells.
Resistance exercise alleviates skeletal muscle atrophy through reduction of oxidative stress via Sestrin1 in C57BL/6J mice.
Adaptive bilirubin nanoscavenger alleviates pulmonary oxidative stress and inflammation for acute lung injury therapy.
Astrocyte-Specific Nrf2 Expression Transforms Neurotoxic Reactive Astrocytes to Neuroprotective Phenotype in 3xTg-AD Mice.
Lymph node environment drives FSP1 targetability in metastasizing melanoma.
Punicalagin Ameliorates Diabetic Cognitive Dysfunction by Inhibiting Neuroinflammation via the CX3CL1/CX3CR1 Axis.
Ononin induces ferroptosis in colorectal cancer cells via the PI3K/AKT/Nrf2 pathway to enhance anti-cancer immunotherapy.
Transdermal delivery of salvianolic acid B using thermosensitive hydrogel for the treatment of skin photoaging.
Kaempferol Mitigates CSE-Induced Lung Injury and Epithelial Cell Ferroptosis via Modulating Nrf2/NCOA4/GPx4 Axis.
Ammonium tetrathiomolybdate ameliorates heat stroke-induced murine liver injury by activating the Nrf2/HO-1 signaling pathway and inhibiting oxidative stress.
Eugenol attenuates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the Nrf2/GPX4 pathway.
7,8-Dihydroxyflavone protects acetaminophen induced liver injury through activating PI3K/Akt/NRF2/GPX4 mediated ferroptosis suppression.
SS-31 improves post-cardiac arrest brain injury by inhibiting microglial ferroptosis and polarization.
Exploring the Active Substances and Mechanism of Physalis Calyx seu Fructus Against Inflammation-related Respiratory Diseases via Integrating Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry, Network Pharmacological Analysis, and Experimental Verification.
Lipocalin-2 induces macrophage/microglia pro-inflammatory phenotype after intracerebral hemorrhage via Nrf2 signaling inhibition in young and aged mice.
PIM1 protects pancreatic ductal cancer cells from glucose deprivation-induced oxidative stress via OXR1 phosphorylation.
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Nobiletin Ameliorates Skeletal Muscle Performance in D-Galactose-Induced Aging Mice by Boosting Aerobic Metabolism.
A proteomics-based study on the mechanisms of Terminalia chebula Retz processed Aconitum kusnezoffii Reichb against rheumatoid arthritis and its cardiotoxicity reduction.
Exosomes derived from ADSC suppress endothelial cells ferroptosis and alleviate sepsis acute liver injury via regulation of Keap1/Nrf2/GPX4 axis.
RVG-targeted extracellular vesicles loaded with echinatin attenuate dopaminergic neurodegeneration via the IGF-2/PI3K/Akt pathway in Parkinson's disease mice.
Methotrexate-triggered ferroptosis suppresses oral cancer progression by phosphorylated KEAP1-mediated NRF2 degradation to inhibit SLC7A11/GPX4 signaling pathway.
Effects of Blue Light Exposure on Hepatic Inflammation and Gut Microbiota in Mice Consuming a High-Fat, High-Fructose Diet.
Low-Intensity pulsed ultrasound reduces ovarian cryopreservation injury through the Notch signaling pathway.
α-Lipoic Acid Alleviates Non-Alcoholic Fatty Liver Disease by Elevating Chaperone-Mediated Autophagy and Increasing β-Oxidation via AMPK-TFEB Axis.
The PI3K/AKT/NRF2 Signaling Pathway Involved in the Improvement of CUMS-Induced Depressive-like Behaviors by Apigenin.
Human amniotic mesenchymal stem cell-derived extracellular vesicles improve oocyte quality and embryonic development by increasing antioxidant capacity in aged mice.
PKM2 preconditioning protects endothelial cells from pyroptosis and BBB disruption via NRF2/TRX/TXNIP signaling in neonatal hypoxic-ischemic brain injury.
Repositioning of Alogliptin to Mitigate Secondary Injury Induced by Repetitive TBI: Potential Role of its Antioxidant and Anti- Inflammatory Effects.
Celastrol mitigates diabetic kidney disease by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 pathway.
Dunaliella salina-Loaded Diosmetin Carriers Alleviate Oxidative Stress and Inflammation in Cisplatin-Induced Acute Kidney Injury via PI3K/AKT Pathway.
Detection of factors related to ROS and ERS in the reproductive organs of hibernating Daurian ground squirrels (Spermophilus dauricus)†.
YangXue QingNao Wan ameliorates vascular dementia in 2-VO rats via inhibition of ferroptosis.
Explore the chemical components of Angong Niuhuang Pill and its potential mechanisms for fever treatment based on UHPLC-Q-Exactive orbitrap HRMS, transcriptomics, and experiment verification.
Coptisine mitigates acute lung injury by alleviating ferroptosis through the PI3K/AKT/Nrf2 pathway.
Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration.
Theacrine protects vascular endothelial cells against oxidative damage after ischemic stroke by inhibiting Rac1 and activating Nrf2 pathway.
Carnosic acid attenuates ventilator-induced diaphragmatic dysfunction via activation of the Nrf2/HO-1 pathway.
Lycium barbarum polysaccharide LBP3 alleviates 5-Fluorouracil-induced intestinal injury via a mechanism associated with activating Nrf2 and improving mitochondrial function.
Forsythoside B protects cartilage and subchondral bone in osteoarthritis by regulating the Nrf2/NF - κ B signaling pathway.
Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer.
FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages.
Gastrodin alleviates alcohol-induced developmental and neurotoxic effects in zebrafish larvae by suppressing ferroptosis via regulating the Nrf2/GPX4 signaling pathway.
Dose-Dependent Ferroptosis Induction in Osteosarcoma via NRF2/GPX4 Axis Modulation by Plasma-Activated Liquid Therapy.
Ezetimibe attenuates diabetic retinopathy via NRF2-mediated suppression of inflammation and oxidative stress.
A multi-omics approach reveals PFHxS as an environmental driver of gastric cancer via KEAP1 downregulation.
Dose-Dependent Biphasic Effect of Palmitic Acid on Oligodendrocyte Function: Impacts on Viability, Differentiation, and Myelination.
Apigenin alleviates DFZ-induced cardiac, renal, and intestinal injury in carp by modulating oxidative stress and inflammatory responses.
Melatonin counteracts Iodoacetic acid induced ferroptosis by regulating Nrf2 in porcine oocytes.
Idebenone alleviates rotenone-induced mitochondrial dysfunction through mitophagy and mitochondrial biogenesis in muscle cells.
FSHR-targeting tetrahedral DNA frameworks ameliorate ovarian aging through oxidative stress elimination.
Mangosteen (Garcinia mangostana) Pericarp and Leaf Tinctures Inhibit LPS-Induced Pro-Inflammatory Responses in Macrophages and Activate Nrf2.
VAMP7 governs ferroptosis suppression and cisplatin resistance in esophageal cancer: a dual-targeting therapeutic paradigm.
The dual functions of a nor-sesquiterpene-triazole derivative against influenza A viruses through the activation of the Nrf2/HO-1 signaling pathway and interaction with hemagglutinin.
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
Pramipexole alleviates ferroptosis in HT22 cells induced by oxygen-glucose deprivation/reoxygenation via the Nrf2/SLC7A11/GPX4 pathway.
Selenoprotein thioredoxin reductase 1 promotes cancer cells ferroptosis by suppressing GPX4 expression.
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells.
N-Salicyloyl Tryptamine Derivatives Improve Mitochondrial Function To Treat Alzheimer's Disease.
Targeting mitochondrial phosphatase PGAM5 alleviates ferroptosis and acute pancreatitis by upregulating NRF2-mediated FSP1 expression.
Pterostilbene Promotes Spinal Cord Injury Recovery by Inhibiting Ferroptosis via Keap1/Nrf2/SLC7A11/GPX4 Axis Activation.
Targeting oxidative stress and mitochondrial dysfunction via URG7 overexpression in an in vitro Parkinson's disease neuronal model.
SREBP1 knockdown triggers ferroptosis by suppressing the Nrf2-XCT/GPX4 axis in ovarian cancer.
Diosmetin, an active ingredient of Schizonepeta tenuifolia, alleviates acne by regulating inflammation and oxidative stress.
The role of glutamine/Nrf2-enhanced PHGDH in Cadmium-induced lactate utilization.
Fusobacterium nucleatum drives endothelial cell senescence by disrupting NOX4/NRF2 balance.
Inhibition of MAGL ameliorates glucocorticoid-induced bone loss by regulating the Nrf2 signaling.
Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis.
Fisetin alleviates lipopolysaccharide-induced mastitis by inhibiting ferroptosis and modulating the gut microbiota.
Discovery of ferulic acid carbamate derivatives as dual-targeting agents of BuChE and Nrf2 for Alzheimer's disease.
Resveratrol Attenuates Neuroinflammation and Myelination Deficits in Repeated Sevoflurane-Exposed Neonatal Mice.
Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1.
OSBPL3 promotes LUAD metastasis and glycolysis through transcriptional upregulation of PLAU via NFE2L2.
Ultrasound-activated piezoelectric Silk-PVDF hydrogel reprograms the osteoimmune microenvironment via NRF2 signaling for accelerated bone regeneration.
NRF2-TERT-ACSL4 pathway inhibits ferroptosis and regulates cytoskeletal dynamics to mitigate ovarian aging.
Puerarin attenuates myocardial ischemia‑reperfusion injury by inhibiting myocardium pyroptosis via the NRF2/HO‑1 signaling pathway.
Nutritional activation of the Nrf2-Pth1r axis by pyrroloquinoline quinone enhances peak bone mass and potentiates teriparatide in osteoporosis.
Epigallocatechin gallate ameliorates brain injuries after intracerebral hemorrhage by inhibiting ferroptosis through upregulation of Nrf2-Keap1 pathway.
Ferulic acid activates Nrf2/HO-1 signaling axis to ameliorate neuronal Golgi stress by SKP2.
The ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis.
Pyrroloquinoline quinone alleviates age-related osteoarthritis via nuclear factor erythroid 2-related factor 2-mediated stress response and insulin-like growth factor 1 receptor upregulation.
Lactate modulates microglial M2 polarization via H3K9 lactylation in ischemic stroke.
Engineered Mesenchymal Stem Cells with Endogenous Trehalose Expression Activate the NRF2-HMOX1 Pathway to Enhance Antioxidant Stress and Wound Healing Capacity.
Targeting SAT1 alleviates high glucose-induced tubular ferroptosis and fibrosis: implications for diabetic kidney disease.
Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis.
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains.
The curcumin derivative DMC-GF promotes ferroptosis through the Nrf2/HMOX1 pathway, increasing glioma susceptibility to temozolomide.
Discovery of novel Keap1-targeting hydrophobic tag (HyT) tethering degraders with potent Nrf2 activation activity.
Notopterol attenuates atherosclerosis by promoting macrophage cholesterol efflux via targeting KEAP1/NRF2 interaction.
Baicalein alleviates Western diet-induced obesity via metabolically activated adipose tissue macrophages by inducing Nrf2.
Peroxisome-derived and liver-specific hydroxyacid oxidase 1-mediated hydrogen peroxide promotes ferroptosis by augmenting peroxisomal ROS.
Targeting CXCL16-expressing macrophages with a biomimetic nanocarrier system attenuates cartilage degeneration in osteoarthritis.
Moxibustion delays ovarian aging by regulating mitochondrial biogenesis and improving oocyte quality.
α-Lipoic Acid Activates the Nrf2/HO-1 Pathway to Ameliorate Arsenic-Induced Multiorgan Oxidative Damage.
Chronic Psychological Stress Activates TRP/TAM/CXCL1 Signaling to Promote Breast Cancer Adipocyte Lipolysis via KEAP1 m(6)A Demethylation.
EDEM1 Inhibits Endoplasmic Reticulum Stress to Induce Doxorubicin Resistance through Accelerating ERAD and Activating Keap1/Nrf2 Antioxidant Pathway in Triple-Negative Breast Cancer.
Astaxanthin ameliorates allergic rhinitis via suppression of the HMGB1/TLR4 signaling pathway.
Green coffee bean extract rich in chlorogenic acids prevents muscle capillary regression via inhibiting oxidative stress and enhancing angiogenesis.
Targeting Reactive Oxygen Species and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots.
Sulforaphane alleviates membranous nephropathy by inhibiting oxidative stress-associated podocyte pyroptosis.
Metformin Alleviates Liver Metabolic Dysfunction in Polycystic Ovary Syndrome by Activating the Ethe1/Keap1/PINK1 Pathway.
Macrophage KDM2A promotes atherosclerosis via regulating FYN and inducing inflammatory response.
TRIM32 promotes neuronal ferroptosis by enhancing K63-linked ubiquitination and subsequent p62-selective autophagic degradation of GPX4.
Tetramethylpyrazine attenuates sodium arsenite-induced acute kidney injury by improving the autophagic flux blockade via a YAP1-Nrf2-p62-dependent mechanism.
Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells.
Imbalance of Bone Homeostasis Caused by Nrf2 Deficiency Leads to Bone Loss in OVX Rats.
Human umbilical cord mesenchymal stem cell-derived exosomes mitigate acute radiation-induced intestinal oxidative damage via the Nrf2/HO-1/NQO1 signaling pathway.
Voluntarily wheel running protects doxorubicin-induced kidney injury by inhibiting oxidative stress through mitochondrial function.
Chlorogenic acid inhibits NLRP3 inflammasome activation through Nrf2 activation in diabetic nephropathy.
Exosomes Derived From Human Mesenchymal Stem Cells Mitigate Follicular Interstitial Cell Ferroptosis via the miR-26a-5p/PTEN/GPX4 Axis in Rats with Chemotherapy-Induced Premature Ovarian Insufficiency.
Liver-specific Bcl3 Knockout Alleviates Acetaminophen-induced Liver Injury by Activating Nrf2 Pathway in Male Mice.
Magnesium Isoglycyrrhizinate Alleviates Alectinib-Induced Hepatotoxicity by Inhibiting Mitochondrial Damage-Mediated Pyroptosis.
Vaccarin Ameliorates Renal Fibrosis by Inhibiting Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway.
Sakuranetin Prevents Acetaminophen-Induced Liver Injury via Nrf2-Induced Inhibition of Hepatocyte Ferroptosis.
Remimazolam Suppresses Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury by Regulating AKT/GSK-3β/NRF2 Pathway.
Ghrelin alleviates high glucose-induced retinal microvascular endothelial cell injury by activating Nrf2/HO-1 pathway to inhibit ferroptosis.
IGF2BP1 Enhances Neprilysin mRNA Stability to Promote Proliferation, Invasion, and Angiogenesis in Placental Trophoblasts.
Hylotelephium mingjinianum Extract Attenuates Oxidative Stress and Inflammation in Experimental Periodontitis.
Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense.
Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway.
Curculigoside alleviates ferroptosis in renal interstitial fibrosis by regulating the Nrf2/HO-1 signaling pathway.
TYMS Enhances Colorectal Cell Antioxidant Capacity Via the KEAP1-NRF2 Pathway to Resist Ferroptosis.
Adipose tissue-specific Nrf2 knockdown inhibits the cGAS-STING pathway to attenuate inflammation in obese mice.
Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk.
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of acteoside in the treatment of diabetic nephropathy.
Targeted ferroptosis of myofibroblasts by tubeimoside I attenuates hypertrophic scar formation.
Fangchinoline attenuates hepatic fibrosis by regulating taurine metabolism and oxidative stress.
Jianpi-Huayu-Jiedu formula improves metabolic dysfunction-associated steatohepatitis through ameliorateing hepatic oxidative stress and lipid accumulation in vivo and in vitro.
Iridoids derived from Valeriana jatamansi Jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signaling pathway.
Polygala tenuifolia Willd. Extract delays non-alcoholic fatty liver disease progression in rats via the COX2 and PERK-elF2α-ATF4 pathway.
Nrf2-dependent effects of CDDO-Me on bactericidal activity in macrophage infection models.
Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis.
α-Mangostin prevents diabetic cardiomyopathy by inhibiting oxidative damage and lipotoxicity through the AKT-FOXO1-CD36 pathway.
Suppression of NLRP3 inflammasome by a small molecule targeting CK1α-β-catenin-NF-κB and CK1α-NRF2-mitochondrial OXPHOS pathways during mycobacterial infection.
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway.
Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway.
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
Embryonic heat conditioning induces paternal heredity of immunological cross- tolerance: coordinative role of CpG DNA methylation and miR-200a regulation.
A multifunctional injectable microsphere with enhanced near-infrared photo-antibacterial, ROS scavenging, and anti-inflammatory properties for periodontitis treatment.
Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons.
The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma.
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Hydrogen improves the efficacy of tetrandrine in the treatment of silicosis by inhibiting vascular endothelial mesenchymal transition caused by oxidative stress.
Garlic oil-loaded nanodisks for the amelioration of acute lung injury via modulation of the NF-κB and Keap1-Nrf2 axis.
Comparative hepatoprotective effects of AMK and PAMK via Nrf2 signaling in broiler breeders.
Phytochemical nanozymes reprogram redox for balanced antimicrobial and regenerative therapy in acute and chronic diabetic wounds.
Chaperone-Mediated Autophagy Reactivation Protects Against Severe Acute Pancreatitis-Associated Liver Injury Through Upregulating Keap1/Nrf2 Signaling Pathway and Inhibiting NLRP3 Inflammasome Activation.
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
Uric Acid Stimulates PINK1/Parkin-Mediated Mitophagy via Nrf2/HO-1 Pathway to Protect Against Neuronal Apoptosis in Alzheimer's Disease.
Reorganization of Mitochondrial Function and Architecture in Response to Plant-Derived Alkaloids: Anatabine, Anabasine, and Nicotine, Investigated in SH-SY5Y Cells and in a Cellular Model of Parkinson's Disease.
Nuclear export of transmembrane protein PROM2 is specially regulated by CRM1 and affects the sensitivity of ferroptosis in gastric cancer.
High mobility group box 1, a novel serotonin receptor-7 negative modulator, contributes to M2 microglial ferroptosis and neuroinflammation in post-stroke depression.
NADPH oxidase-dependent heme oxygenase-1 expression mediates cigarette smoke-induced ferroptosis via intracellular Fe(II) accumulation.
Acetyl-CoA carboxylase activation disrupts iron homeostasis to drive ferroptosis.
METTL5 triggers the ferroptosis of cardiomyocytes in sepsis-induced myocardial injury.
High-throughput profiling of chemical-induced gene expression across 93,644 perturbations.
Unraveling the molecular mechanisms of paraquat toxicity: The interplay of ATF4, ferroptosis, and endoplasmic reticulum stress.
Melatonin protects dopaminergic neurons in paraquat-induced Parkinson in rats through PI3K/AKT/Nrf2 pathway.
Involvement of the PINK1/Parkin signaling pathway in 4-vinylcyclohexene diepoxide-induced ovary toxicity in rats.
Bioactive ROS-responsive nanotherapeutics attenuate intermittent hypoxia-induced cognitive impairment via NRF2/KEAP1/HO-1 signaling.
TMI, an isoflavone from the fruits of Ficus altissima Blume, overcomes K562/ADR leukemia cells resistance by targeting Nrf2.
Optimized synthesis of 5N-D and the exploration of its role as a promising anti-aging agent via AKR1B1 inhibition and PI3K/Akt/Nrf2 regulation.
Agathic acid derivatives including a novel ferroptosis inhibitor from the fungus Penicillium thomii.
An SPR-based active ingredient recognition strategy for identifying PLK1-targeting withanolides as natural ferroptosis inducers.
Regulatory role of ATF2 in trophoblast ferroptosis via the PI3K/Akt/Nrf2 pathway in gestational diabetes mellitus.
β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.
Tectorigenin attenuates myocardial damage by doxorubicin-induced ferroptosis by activating the p62-Keap1-Nrf2/HO-1/GPX4 axis.
Dihydrotanshinone I targets the spike N-terminal domain to inhibit SARS-CoV-2 entry and spike-induced inflammation.
Dendrobium huoshanense improves atherosclerosis in high-fat-induced ApoE mice by regulating gut microbiota and serum metabolite profiles.
Artemisitene Ameliorates Diabetic Wounds by Inhibiting Ferroptosis Through Activation of the Nrf2/GPX4 Pathway.
Investigating the role of 1,8-Cineole in mitigating ferroptosis in a HFSD/STZ diabetes mellitus type 2-induced model: A GEO data analysis approach.
α-Cyperone safeguards against cerebral ischaemia‒reperfusion injury through the activation of the Nrf2 signalling pathway.
Teneligliptin, a DPP4 inhibitor protects dopaminergic neurons in PD models via inhibiting of oxidative stress and ferroptosis.
Isoacteoside alleviates LPS-induced depressive-like behaviors in mice by inhibiting neuroinflammation through regulating microglial polarization and oxidative stress.
Soluble urokinase plasminogen activator receptor promotes endoplasmic reticulum stress and apoptosis susceptibility through RAGE in sepsis acute kidney injury.
Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway.
Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis.
Atractylenolide III attenuates acute kidney injury through phosphorylation of PIK3CA: Functional activation and molecular interaction analysis.
Disrupting mitochondrial dynamics attenuates ferroptosis and chemotoxicity via upregulating NRF2-mediated FSP1 expression.
Inhibition of MMP9 ameliorates neutrophil extracellular traps-mediated necroptosis through regulation of impaired autophagy in severe acute pancreatitis.
Shikimic Acid Mitigates Deoxynivalenol-Induced Jejunal Barrier Injury in Mice via Activation of the Nrf-2/HO-1/NQO1 Pathway and Modulation of Gut Microbiota.
Sheng Mai San Mitigates Heat Stress-Induced Myocardial Injury by Coordinated Regulation of the Keap1-Nrf2-HO-1 and Stub1-HSF1 Signaling Pathways.
Hydrogen Sulfide-Preconditioned Mesenchymal Stem Cells Attenuate Ferroptosis in Corneal Alkali Burn via the AMPK/Nrf2/HO-1 Pathway in an IL-10-Dependent Manner.
Dovitinib Ameliorates Inflammation-Related Diseases by Inhibiting Necroptosis and Ferroptosis.
Sinomenine Modifies Parkinson's Disease Through Nrf2 Activation.
Integrating network pharmacology and experimental validation to decipher the protective effect of icariin against testicular aging.
Early-life glyphosate exposure impairs intestinal antioxidant status and induces growth retardation in post-hatched chicks.
RSL1D1 regulates lung adenocarcinoma progression by inhibiting NRF2 ubiquitination.
Transcription factor RUNX2 participates in astrocyte-mediated neuropathic pain via transcriptional activation of Ccl2.
Influence of Sevoflurane Postconditioning on Hypoxic-Ischemic Brain Injury via Nrf2-Regulated Ferroptosis in Neonatal Rats.
Helicobacter pylori modulates macrophage polarization via the glucocorticoid receptor to promote gastric cancer cell proliferation.
Codonopsis pilosula polysaccharides attenuate lipid accumulation and inflammatory response in the NAFLD mouse by regulating AMPK/ACC/SREBP1 signaling pathway.
YAP/Nrf2 suppresses ferroptosis to alleviate acute lung injury induced by intestinal ischemia/reperfusion.
Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation.
Oxidative modulation of Piezo1 channels.
Sleep deprivation affects pain sensitivity by increasing oxidative stress and apoptosis in the medial prefrontal cortex of rats via the HDAC2-NRF2 pathway.
Non-Apoptotic Inhibition of Colorectal Cancer Proliferation by Sclareol via Ferroptosis Involving SLC7A11/GPX4 Modulation.
The SLCO4A1-Mediated Transmembrane Transport of Lysionotin Attenuates Acute Lung Injury Through Activating the AMPK/Nrf2 Signaling Pathway.
The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25.
Oligodendrocyte-specific knockout of FPN1 affects CNS myelination defects and depression-like behavior in mice.
Guanosine enhances thermogenesis and impairs KEAP1-mediated NRF2 degradation to resist ferroptosis in brown adipose tissue.
Honokiol protects against heavy-ion radiation-induced oxidative damage via the thioredoxin system.
Hinokitiol modulates Nrf2/HO-1 signaling, autophagy, and URAT1 in hyperuricemia and oxidative stress models of renal injury.
Limosilactobacillus reuteri-butyrate axis in depression therapy: A key pathway discovered through a novel preclinical human flora-associated animal model.
CROT overactivation within peroxisomes confers chemoresistance to non-small cell lung cancer by targeting fatty acid oxidation-Nrf2-ferroptosis resistance axis.
Enhancing the encapsulation efficiency, bioavailability, and antioxidant efficacy of quercetin and maize peptide by a novel multi-frequency pulsed ultrasonic-assisted nanoliposomal encapsulation system.
CDDO-Me triggers ROS-dependent ferroptosis and apoptosis in cervical cancer via targeting PI3K/Nrf2 pathway.
Brusatol suppresses malignant progression of glioma via modulating the miR-574-5p/USP10/PLK1 axis.
Natural exosome-like nanovesicles from Salvia chinensis Benth induce ferroptosis to suppress hepatocellular carcinoma progression via AMPK/Nrf2/xCT axis.
Shikonin Ameliorates Alcohol-Associated Liver Disease by Reducing Oxidative Stress, Apoptosis, and Inflammation.
Protective Effects Proanthocyanidin Nanoliposome Freeze-Dried Powder on Oxidative Injury in a p31-43 Induced Celiac Disease Cell Model.
Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic-Induced Transformation.
Ferroptosis and iron metabolism drive fibroblast activation in silicosis: insights from a novel 3D lung matrix model.
Dual-targeting antioxidant and anti-glycation strategy inhibits melanogenesis through clinical and mechanistic study.
Lactoferrin and Osteopontin Cooperatively Promote Intestinal Epithelial Maturation in Neonatal Mice by Activating the Brg1/Notch1/Hes1 Pathway.
HBHP ameliorates CCL4-induced liver fibrosis in rats by inhibiting HMGB1-mediated inflammatory response through binding to the HMGB1-A box.
SIRT3 mediates Tubeimoside I's inhibition on pulmonary artery smooth muscle cell proliferation and oxidative stress in pulmonary arterial hypertension.
Harpagide Confers Protection Against Acute Lung Injury Through Multi-Omics Dissection of Immune-Microenvironmental Crosstalk and Convergent Therapeutic Mechanisms.
Targeting PARK7: Sodium 4-Phenylbutyrate shields endothelial cells from oxidative stress and GSDME-mediated Pyroptosis in acute lung injury.
Neuroprotective Effects and Mechanisms of Arecoline Against H(2)O(2)-Induced Damage in SH-SY5Y Cells.
Design and Synthesis of Senescence-Targeted Prodrugs with Senomorphic and Senolytic Properties To Mitigate Chemotherapy-Induced Kidney Injury.
Apigenin Alleviates Fumonisin B1-Induced Hepatotoxicity by Suppressing Ferroptosis through the Nrf2/FSP1 Pathway.
Menaquinone-4 ameliorates abdominal aortic aneurysm by suppressing ferroptosis through NRF2/GCLM axis.
Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility.
Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway.
α-Asarone Maintains Protein Homeostasis Through SKN-1-Mediated Proteasome and Autophagy Pathways to Mitigate Aβ-Associated Toxicity in Caenorhabditis elegans.
Impact of endogenous vasohibin 1 and vasohibin 2 gene expression on ferroptosis in a mouse cerebral infarction model.
Hydrogen promoted mitochondrial autophagy and alleviated CIH-induced vascular endothelial cell senescence by regulating oxidative stress.
Fermentation of Panax ginseng C.A. Meyer extract with lactic acid bacteria exerts hepatoprotective effects via activating the NRF2 pathway.
Identification of disease-associated molecular signatures in the Prp-TDP-43A315T mouse model of ALS: Toward preclinical biomarker development.
Inhibition of ferroptosis by serine protease inhibitor attenuates acute respiratory distress syndrome.
miR-144-3p suppression mediates Nrf2 activation induced by developmental arsenic exposure in mice.
NFE2L2 protects against Sorafenib-induced Ferroptosis and cardiotoxicity by activating the HO1/ferritin pathway.
Carnosol attenuates Ang II-induced renal injury by p62-KEAP1-NRF2 signaling pathway.
Panax ginseng alleviates diabetic peripheral neuropathy by suppressing mitochondrial dysfunction and oxidative stress via modulation of the RAGE, NF-κB, and Nrf2 pathways.
NPB-1575 attenuates neuroinflammation and resists ferroptosis in rat ischemic stroke via IRS2 signaling pathway.
ML385 increases ferroptosis via inhibiting Nrf2/HO-1 pathway to enhances the sensitivity of MCF-7 TAMR to tamoxifen.
Astragaloside IV Alleviates Cisplatin Chemotherapy-Induced Nephrotoxicity via Modulation of Nrf2/HO-1/NF-κB Pathway and Reversal of EMT Process.
Preprotective Effects of Cardamomin From Amomum villosum Lour. on H(2)O(2) -Induced Oxidative Damage In Vitro and Cerebral Ischemic Stroke In Vivo.
Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2-HO-1 Pathway.
Structural characterization and functional role of SLC7A6 in GSSG transport and Ferroptosis regulation.
Kaempferol prevents Nrf2 from ubiquitin-mediated proteolysis to mitigate both NLRP3 inflammation and oxidative stress: implications for alleviating DSS-induced colitis in mice.
Salidroside improves bovine embryo quality by mitigating oxidative stress and regulating mitochondrial lipid metabolism.
Collagen peptides from Skipjack tuna (Katsuwonus pelamis) bones: Composition, characterization, and mechanism of high-fat diet-induced NAFLD amelioration.
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
Gut microbiota-bile acid metabolic disorder involved in the cognitive impairments in epilepsy through HO-1 dependent ferroptosis.
CX-5461 inhibits cell proliferation and induces ferroptosis of colorectal cancer cells by inactivating Nrf2 pathway.
Epigallocatechin-3-Gallate Mitigates Atopic Dermatitis-Like Skin Lesions and Psychiatric Comorbidities by Reducing Oxidative Stress.
Anthocyanin-functionalized selenocysteine nanotherapeutics alleviate cisplatin nephrotoxicity by inhibiting oxidative stress and ferroptosis.
Anthraquinone Rhein Mitigates Heavy Ion Radiation-Induced Lung Injury by Maintaining Thioredoxin Reductase/Thioredoxin (TrxR/Trx) Redox Homeostasis.
Taoren Honghua Jian improves ferroptosis-mediated myocardial damage following myocardial infarction via Nrf2-dependent enhancement of GPX4/FSP1.
Sestrin2 ameliorates LPS-induced cardiomyocyte injury by inhibiting ferroptosis via the Nrf2/HO-1 pathway.
The protecting role of Ganoderma lucidum polysaccharides on the retinal neurovascular units in rats with retinal ischemia-reperfusion injury.
FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice.
Unveiling tectorigenin: A novel ferroptosis inducer targeting EGFR in bladder cancer.
Mechanism and potential targets of kaempferol alleviating photothrombotic stroke via integrating experimental validation, network pharmacology, and molecular docking.
Neuro-skeletal crosstalk: Brain-derived 5-HT mediates the bone-protective effects of β-Sitosterol against postmenopausal osteoporosis.
Generation of antifungals to combat drug resistance using language models and diffusion models.
Metformin mitigates cisplatin-induced premature ovarian insufficiency via Sirt1/Nrf2 activation.
Dendrobine alleviates CCl(4)-induced acute liver injury by inhibiting necroptosis through activation of the Nrf2/PPARγ/SOD2 signaling pathways.
Synergistic antitumor activity of sorafenib and the NUPR1 inhibitor LZX-2-73 in multiple cancer models.
ChaC1-based drug screenings identify a synergistic lethal effect of auranofin and proteasome inhibitors in hepatocellular carcinoma cells.
Sotagliflozin attenuates atrial oxidative stress and the susceptibility to atrial fibrillation by activating the NRF2/HO-1 pathway.
AICAr Inhibition of cardiomyocyte autophagy promotes p62-dependent NRF2 expression and protection against doxorubicin toxicity.
Chrysin Improves Cognitive Dysfunction in Rats with Intracerebral Hemorrhage by Regulating the Nrf2/GPX4 Pathway to Inhibit Ferroptosis.
Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes.
SGK1 inhibits oxidative injury and extracellular matrix degradation by activating the GSK-3β (Ser9)/Fyn/NRF2 pathway in pelvic organ prolapse.
Hydroxysafflor yellow A attenuates the blood-brain barrier dysfunction and neuroinflammation through anti-inflammatory microglial polarization after intracerebral hemorrhage.
Targeting PIM1 by Bruceine D attenuates skin fibrosis via myofibroblast ferroptosis.
Optineurin Cooperates With NRF2 to Regulate Tooth Root Morphogenesis by Controlling Mitochondrial Dynamics and Apoptosis.
Therapeutic effect of edaravone on osteoarthritis: targeting NRF2 signaling and mitochondrial function.
Methyltransferase-like enzyme 14 exacerbates retinal ganglion cell damage and diabetic retinopathy through N6-methyladenosine-dependent upregulation of pleckstrin homology domain and leucine rich repeat protein phosphatase 2.
Sirt1 overexpression inhibits chondrocyte ferroptosis via Ftl deacetylation to suppress the development of osteoarthritis.
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
Astragalus polysaccharide alleviates oxidative stress and senescence in chondrocytes in osteoarthritis via GCN2/ATF4/TXN axis.
11,12-Diacetyl-Carnosol Ameliorates Depression-Like Behaviors and Memory Dysfunction in CUMS Mouse Model via Inhibiting HMGB1-Mediated Neuroinflammation.
Hyaluronic acid-modified PtPdCo-CQ nanocatalyst with triple enzyme-like activities regulates macrophage polarization and autophagy levels for the treatment of rheumatoid arthritis.
Isoquercetin alleviates osteoarthritis via regulating the NOX4/Nrf2 redox imbalance in senescent chondrocytes.
Bacteria escape macrophage-mediated phagocytosis via targeting apurinic/apyrimidinic endonuclease 1 in sepsis.
Glucomannogalactan inhibits senescence by promoting nuclear translocation of NRF2.
Salvianolic acid B protects against UVB-induced HaCaT cell senescence and skin aging through NRF2 activation and ROS scavenging.
EPA-enriched lipid from Apostichopus japonicus byproducts mitigates UVB-induced oxidative stress and inflammation by gut-skin axis.
Shenqi granules enhance recovery from cerebral ischemia-reperfusion injury by modulating tryptophan and tyrosine metabolism and activating NFE2L2/NRF2.
Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality.
Methyl 3,4-dihydrobenzoate attenuates muscle fiber necroptosis and macrophage pyroptosis by regulating oxidative stress in inflammatory myopathies.
Cell-Free Fat Extract for the Treatment of Lumbar Disc Degeneration: A Novel Approach Using Adipose-Derived Biologic.
Creatine ameliorates the adverse effects of high-fat diet on hepatic lipid metabolism, intestinal health, muscle growth and flesh quality in juvenile largemouth bass (Micropterus salmoides).
Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury.
PICK1 overexpression ameliorates endotoxin-induced acute lung injury by regulating mitochondrial quality control via maintaining Nrf-2 stabilization through activating the PI3K/Akt/GSK-3β pathway and disrupting the E3 ubiquitin ligase adapter β-TrCP.
Study on the Mechanism of Dihydromyricetin in Alleviating Depressive-Like Behavior in Rats Based on Network Pharmacology.
The antioxidant stress effect of granulin precursor in vitiligo.
Protective Effect of Zeaxanthin from Lycium barbarum L. on Ultraviolet B-Induced Skin Photodamage in Mice Through Nrf2-Related Pathway.
Melatonin inhibits salivary gland epithelial cell ferroptosis via the NRF2/HO-1/GPX4 signaling pathway in primary Sjögren's syndrome.
Sheng Mai San Modulates the Heart-Gut-Microbiota Axis to Mitigate Heat Stress-Induced Damage in Rats.
Fisetin Attenuates Zinc Overload-Induced Hepatotoxicity in Mice via Autophagy-Dependent Nrf2 Activation.
Study on Cellular Mechanism of Improving Inflammatory Effect of Gastrodin.
Targeting HMGB2 acts as dual immunomodulator by bolstering CD8(+) T cell function and inhibiting tumor growth in hepatocellular carcinoma.
Orientin attenuates UVB-induced skin photodamage by inhibiting ROS generation via the AMPK/Nrf2 axis.
Exposure to Sucralose and Its Effects on Testicular Damage and Male Infertility: Insights into Oxidative Stress and Autophagy.
Unraveling the impact of micro- and nano-sized polymethyl methacrylate on gut microbiota and liver lipid metabolism: Insights from oral exposure studies.
Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata.
Far-Infrared Radiation Ameliorates the Cognitive Dysfunction in an Alzheimer's Disease Transgenic Mouse via Modulating Jak-2/Stat3 and Nrf-2/HO-1 Pathways.
The STEAP4 target NQO1 mediates colon tumorigenesis.
CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer.
Dauricine Impedes the Tumorigenesis of Lung Adenocarcinoma by Regulating Nrf2 and Reactive Oxygen Species.
Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes.
Tea Polyphenols Mitigate Radiation-Induced Ferroptosis and Intestinal Injury by Targeting the Nrf2/HO-1/GPX4 Signaling Pathway.
The anti-Alzheimer's disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway.
Lentinan alleviates cadmium-induced kidney injury by reducing cadmium accumulation via promoting cadmium excretion and metallothionein synthesis and regulating silencing information regulator1/nuclear factor erythroid 2-related factor 2/nuclear factor kappa-B signaling pathway.
Hsa-miR-532-3p protects human decidual mesenchymal stem cells from oxidative stress in recurrent spontaneous abortion via targeting KEAP1.
Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles alleviates atherosclerosis by suppressing macrophage ferroptosis via the NRF2/SLC7A11/GPX4 pathway.
Inhibition of Phosphodiesterase 4 Suppresses Neuronal Ferroptosis After Cerebral Ischemia/Reperfusion.
Curcumin Alleviates Microglia-Mediated Neuroinflammation and Neuronal Ferroptosis Following Experimental Subarachnoid Hemorrhage by Modulating the Nrf2/HO-1 Signaling Pathway.
Pleiotrophin Prevents H(2)O(2)-Induced Senescence of Dental Pulp Stem Cells.
The potential role of the SIRT1-Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress.
AKAP1/PKA-mediated GRP75 phosphorylation at mitochondria-associated endoplasmic reticulum membranes protects cancer cells against ferroptosis.
The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress.
Single amino acid substitution analogs of marine antioxidant peptides with membrane permeability exert a marked protective effect against ultraviolet-B induced damage.
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease.
USP13 facilitates a ferroptosis-to-autophagy switch by activation of the NFE2L2/NRF2-SQSTM1/p62-KEAP1 axis dependent on the KRAS signaling pathway.
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice.
The protective effect and potential mechanism of Zanthoxylum bungeanum Maxim. on atherosclerosis.
Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function.
Oxymatrine alleviates ALD-induced cardiac hypertrophy by regulating autophagy via activation Nrf2/SIRT3 signaling pathway.
Rosa roxburghii Fermentation Broths Attenuate Bleomycin-Induced Pulmonary Fibrosis by Activating the Nrf2/HO-1/NQO1 Signaling Pathway and Modulating Gut Microbiota.
Redox-Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3-Mediated NRF2 Deubiquitination.
The Lactate-Primed KAT8‒PCK2 Axis Exacerbates Hepatic Ferroptosis During Ischemia/Reperfusion Injury by Reprogramming OXSM-Dependent Mitochondrial Fatty Acid Synthesis.
Gaudichaudione H Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Disulfidptosis via Regulating NRF2-SLC7A11 Signaling Pathway.
Procyanidin B2 alleviates damage to mouse testicular tissue after freezing by inhibiting oxidative stress and apoptosis.
Moscatilin Induces Ferroptosis in Clear Cell Renal Cell Carcinoma via the JAK-STAT Signaling Pathway.
Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.
The predominant role of p62/SQSTM1 over NBR1 in methylmercury-induced cytotoxicity and cellular defense.
Network pharmacology and in vivo study: Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis.
Fructose-Driven glycolysis supports synaptic function in subterranean rodent - Gansu Zokor (Eospalax cansus).
Multifunctional Liposome Delivery System Based on Ursodeoxycholic Acid Sodium for the Encapsulation of Silibinin and Combined Treatment of Alcoholic Liver Injury.
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
BRD4 Mediates Cadmium-Induced Oxidative Stress and Kidney Injury in Mice via Disruption of Redox Homeostasis.
Phenolics and Phenolic Glycosides from Wrightia pubescens and Their Hepatoprotective Activities.
Running a genetic stop sign accelerates oxygen metabolism and energy production in horses.
Agomelatine Alleviates Depressive-like Behaviors by Suppressing Hippocampal Oxidative Stress in the Chronic Social Defeat Stress Model.
Total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack prevents acetaminophen-induced liver injury by activating Keap1/Nrf2 and PI3K/AKT/mTOR signaling pathway.
Wedelolactone activates the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways to alleviate oxidative stress and ferroptosis and improve sepsis-induced liver injury.
Ditan Decoction ameliorates vascular dementia-induced cognitive dysfunction through anti-ferroptosis via the HIF1α pathway: Integrating network pharmacology and experimental validation.
Zuogui Pills alleviate iron overload-induced osteoporosis by attenuating ROS-mediated osteoblast apoptosis via the PI3K-AKT pathway and mitigating mitochondrial damage.
Reprogramming Macrophage Phenotype Using a Reactive Oxygen Species-Responsive Liposome Delivery System for Inflammation Microenvironment Remodeling and Osteoarthritis Treatment.
Adverse Outcome Pathway-Based Strategies to Mitigate Ag(2)Se Quantum Dot-Induced Neurotoxicity.
Gastrodia elata, Polygonatum sibiricum, and Poria cocos as a Functional Food Formula: Cognitive Enhancement via Modulation of Hippocampal Neuroinflammation and Neuroprotection in Sleep-Restricted Mice.
ROS-responsive nanoparticles with selenomethionine for ferroptosis modulation in abdominal aortic aneurysm.
Anti-TNFα and Anti-IL-1β Monoclonal Antibodies Preserve BV-2 Microglial Homeostasis Under Hypoxia by Mitigating Inflammatory Reactivity and ATF4/MAPK-Mediated Apoptosis.
BMAL1 rescued the hippocampus-dependent recognition memory induced by sleep deprivation.
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
Down-regulation of TET2 inhibits testosterone synthesis in offspring mice exposed to DBP during pregnancy through LH/cAMP/PKA/StAR signaling mediated by LHR.
The mechanism of Se in regulating the proliferation and apoptosis of sheep Leydig cells through the miR-200a/NRF2 pathway.
Huachansu Injection induces ferroptosis in multiple myeloma through NRF2/HO-1 signaling pathway.
Gal-3 activates Tyro3 to ameliorate ferroptosis of hippocampal neurons after traumatic brain injury.
A novel KEAP1 inhibitor, tiliroside, activates NRF2 to protect against acetaminophen-induced oxidative stress and acute liver injury.
Merestinib inhibits cuproptosis by targeting NRF2 to alleviate acute liver injury.
Astaxanthin ameliorates benzalkonium chloride-induced dry eye disease through suppressing inflammation and oxidative stress via Keap1-Nrf2/HO-1 signaling pathways.
Administration with Yangxinshi ameliorates the progression of atrial fibrillation by affecting atrial remodeling and oxidative stress via the activation of the PI3K/AKT signaling.
GSK3β Substrate-competitive Inhibitors Regulate the gut Homeostasis and Barrier Function to Inhibit Neuroinflammation in Scopolamine-induced Alzheimer's Disease Model Mice.
Vitamin D Activates Nrf2 to Prevent Nerve Injury and Reduce Brain Damage in Acute Cerebral Infarction.
Fisetin alleviates oxidative stress and promotes porcine early embryonic development via activation of the NRF2-ARE signalling pathway.
Melatonin attenuates brain edema via the PI3K/Akt/Nrf2 pathway in rats with cerebral ischemia-reperfusion injury.
Carnosol mitigates Ang II-stimulated vascular injury and oxidative stress by directly binding to FAK and inhibiting its activation.
Gastrodia elata polysaccharide alleviates depression via gut microbiota modulation and Keap1-Nrf2/BDNF-TrkB pathway activation.
Sanghuangporus vaninii polysaccharides alleviates the effects of chlorpyrifos exposure on mouse liver: role of the gut- liver axis.
Polygonatum cyrtonema polysaccharide alleviates dopaminergic neuron apoptosis in Parkinson's disease mouse model via inhibiting oxidative stress and endoplasmic reticulum stress.
Nrf2-and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic β-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice.
Suppression of NRF2 by photodynamic action to enhance bortezomib-triggered DNA damage for synergistic colorectal cancer therapy.
Bilateral Synergistic Effects of Phototherapy-Based NIR-II Absorption Photosensitizer for Allergic Rhinitis.
Liposome of Phlorizin promote the repair of carotid atherosclerosis in rats by regulating inflammation and the Nrf2 signaling pathway.
Myeloid-specific deficiency of group VIA calcium-independent phospholipase A2 preconditions myeloid cells for injury resolution after acetaminophen exposure.
Methyleugenol alleviates pulmonary vascular remodeling in rats with high-altitude pulmonary hypertension by improving pulmonary smooth muscle cell function.
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
Reprogramming Glucose Metabolism of Macrophage for Acute Liver Failure Therapy with Itaconate Lipo-Nanodrug.
Influence of α-Linolenic Acid on the Intestinal Barrier Integrity and Intestinal Antioxidant Status in Broilers.
Flotillin- 1 ameliorates experimental diabetic retinopathy by inhibiting ferroptosis in blood-retinal barrier.
Antitumor/anti-inflammatory effects/tissue healing as an all-in-one therapeutic strategy for nasopharyngeal carcinoma.
OTUB1-SLC7A11 Axis Mediates 4-Octyl Itaconate Protection Against Acetaminophen-Induced Ferroptotic Liver Injury.
Pterostilbene Reduces Cyclophosphamide-Induced Interstitial Cystitis by Facilitating Nrf2 Activation and Suppressing the NLRP3 Inflammasome Pathway.
Oligo-peptide I-C-F-6 mitigates polymicrobial sepsis-induced cardiac dysfunction in mice.
Sesamin improved growth and overall health in young animals by enhancing gut-liver axis function.
Piezo1 disrupts blood-brain barrier via CaMKII/Nrf2 in ischemic stroke.
MYC promotes group 3 medulloblastoma cell proliferation and alleviates ROS-induced cell death by upregulating transketolase.
Molecular mechanisms of Potentilla Discolor Bunge in regulating ferroptosis to alleviate DKD via the Nrf2 signaling pathway.
Mechanisms of Cisplatin-Induced Acute Kidney Injury: The Role of NRF2 in Mitochondrial Dysfunction and Metabolic Reprogramming.
Endothelial cell Nrf2 controls neuroinflammation following a systemic insult.
Computational design of diverse nuclear factor erythroid 2 activators with cellular antioxidative activity.
Pretreatment with Citrus reticulata 'Chachi' Polysaccharide Alleviates Alcohol-Induced Gastric Ulcer by Inhibiting NLRP3/ASC/Caspase-1 and Nrf2/HO-1 Signaling Pathways.
Identification of CD84 as a potent survival factor in acute myeloid leukemia.
Idebenone Orchestrates Anti-Inflammatory and Antioxidant Responses to Alleviate Brain Injury After Intracerebral Hemorrhage in Mice.
Mechanisms of Aletris spicata (Thunb.) Franch. Extract in Asthma Therapy: Oxidative Stress, Inflammation, and Gut Microbiota.
NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia.
Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice.
ANXA1 inhibits trophoblast ferroptosis in preeclampsia by downregulating KISS1†.
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of velvet antler in the treatment of chronic atrophic gastritis.
Overexpression of the circadian gene Bmal1 regulates the Nrf2/HO-1 oxidative stress pathway to alleviate inflammation and apoptosis in PC12 cells following cerebral ischemia-reperfusion injury.
Protective Effects of Fish Oil Against Brain Impairment in Rats with Chronic Ethanol-Induced Liver Damage Involving the NRF2 Pathway and Oxidative Stress.
Antioxidant interventions reduced cytokine-induced pyroptosis of peripheral MAIT cells in patients with HBV-related cirrhosis.
Activation of TFEB protects against diabetic vascular calcification by improving autophagic flux and activating Nrf2 antioxidant system.
Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.
Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2.
Isomeric 2-isobutylmalate derivatives with anti-pulmonary fibrosis effects from the leaves of Bletilla striata via LC-MS/MS-based molecular networking.
Autophagy hub-protein p62 orchestrates oxidative, endoplasmic reticulum stress, and inflammatory responses post-ischemia, exacerbating stroke outcome.
Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4-regulated ferroptosis.
Aerobic Exercise Activates Fibroblast Growth Factor 21 and Alleviates Cardiac Ischemia/Reperfusion-induced Neuronal Oxidative Stress and Ferroptosis in Paraventricular Nucleus.
Activation of the Nrf2 Signaling Pathway by Tetrahydroberberine Suppresses Ferroptosis and Enhances Functional Recovery Following Spinal Cord Injury.
Ethanol-induced Nrf2 suppression in the lung is mediated by AP-1-driven expression of miR-144.
FNDC5/Irisin exacerbates APAP-induced acute liver injury through activating JNK/NF-κB and inflammatory response.
GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Attenuates Skeletal Muscle Abnormalities in a Murine Model of Duchenne Muscular Dystrophy.
Methacrylated sericin/methacrylated hyaluronic acid composite microneedles with exosomes for diabetic wound healing.
KEAP1 retention in phase-separated p62 bodies drives liver damage under autophagy-deficient conditions.
Coriander-Derived Exosome-Like Nanovesicles Laden Hydrogel with Antioxidant Property Accelerates Wound Healing.
Soyasaponin Bb Attenuates Morphine Withdrawal-Induced Anxiety-Like Behaviors in Male Mice by Rescuing GSK-3β/Nrf2 Signaling.
Lead (Pb) Induces Osteotoxicity Through the Activation of Mutually Reinforced ER Stress and ROS in MC3T3-E1 Cells.
NRF2 modulates WNT signaling pathway to enhance photodynamic therapy resistance in oral leukoplakia.
Fucoxanthin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Mice via Nrf2/HO-1/GPX4-Mediated Ferroptosis Pathway.
Loss of WDR23 slows the rate of age-related cognitive decline with elevated amyloid burden.
Exploring the Protective Effect and Regulatory Mechanism of Plumbagin on Renal Ischemia-Reperfusion Injury Based on the Nrf-2/HO-1 Signaling Pathway.
Interleukin-22 ameliorates alcohol-associated liver fibrosis via Nrf2-ARE signaling: mechanistic insights and clinical correlations.
Dermal papilla cells-conditioned medium attenuates oxidative stress-induced senescence via ferroptosis inhibition.
Dihydromyricetin attenuates intervertebral disc degeneration by inhibiting NLRP3 inflammasome activation via the Keap1/Nrf2/HO-1 pathway.
Fluorinated sulfonamide-flavonoid derivatives as novel Keap1-Nrf2 inhibitors: Potent induction of cytoprotective gene HO-1 in vivo.
Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke.
Galangin Regulates Oxidative Stress Levels in Porcine Embryos Through Interaction with the Neh1 Domain of Nrf2.
Melatonin modulates mitochondrial function and inhibits atherosclerosis progression through NRF2 activation and OPA1 inhibition.
Cadmium Inhibits Proliferation of Human Bronchial Epithelial BEAS-2B Cells Through Inducing Ferroptosis via Targeted Regulation of the Nrf2/SLC7A11/GPX4 Pathway.
DNA damage response pathway regulates Nrf2 in response to oxidative stress.
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
Combination of astragalus polysaccharide with Diosbulbin B exerts an enhanced antitumor effect in BRAF(mut) papillary thyroid cancer with decreased liver toxicity.
High-Fat Diet-Induced Diabetic Cardiomyopathy in Female Zebrafish: Cardiac Pathology and Functional Decline Mediated by Type 2 Diabetes.
Uridine alleviates the aging of alveolar epithelial cells in idiopathic pulmonary fibrosis through the Keap1-Nrf2 signaling pathway.
Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes' expression and upregulating Nrf2/Heme oxygenase-1.
Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization.
Strengthening monocarboxylate transporters by adiponectin receptor agonist ameliorates diabetic peripheral neuropathy.
S-COS-Se mitigates cadmium-induced oxidative stress, inflammation, and immunotoxicity by restoring immune balance and inhibiting mitochondria-pyroptosis crosstalk.
Biochemical Insights into the Effects of a Small Molecule Drug Candidate on Imatinib-Induced Cardiac Inflammation.
Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.
Irisin prevents liver injury during exhausting physical activity by suppressing ferroptosis via Nrf2/GPX4 signaling.
Effects of solamargine in hepatic metastasis of colorectal cancer: induction of ferroptosis and elimination of cancer stem cells.
cDTL contributes to breast cancer progression through regulating redox homeostasis via affecting the function of system xc().
Sulforaphane, Urolithin A, and ZLN005 induce time-dependent alterations in antioxidant capacity, mitophagy, and mitochondrial biogenesis in muscle cells.
AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis.
Shionone Inhibits Glomerular Fibirosis by Suppressing NLRP3 Related Inflammasome though SESN2-NRF2/ HO-1 Pathway.
NEK2 affects the ferroptosis sensitivity of gastric cancer cells by regulating the expression of HMOX1 through Keap1/Nrf2.
MMP-9 responsive hydrogel promotes diabetic wound healing by suppressing ferroptosis of endothelial cells.
Gypenoside XLIX alleviates sepsis-associated encephalopathy by targeting PPAR-α.
Dopamine receptor agonist pramipexole exerts neuroprotection on global cerebral ischemia/reperfusion injury by inhibiting ferroptosis.
Astroglial membrane camouflaged Ptbp1 siRNA delivery hinders glutamate homeostasis via SDH/Nrf2 pathway.
Structural characterization and in vitro hepatoprotective activity of an acidic polysaccharide from Dendrobium nobile Lindl. flower.
Oxidative stress levels and antioxidant defense mechanisms (Nrf2-Keap1 signaling pathway) in the Harderian glands of hibernating Daurian ground squirrels.
Scopoletin ameliorates hyperlipidemia and hepatic steatosis via AMPK, Nrf2/HO-1 and NF-κB signaling pathways.
LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction.
Resveratrol alleviates depression-like behaviors by inhibiting ferroptosis via AKT/NRF2 pathway.
Ingenane diterpenoids with anti-inflammatory activity from Euphorbia antiquorum.
Adipose tissue macrophages-derived exosomal MiR-500a-5p under high glucose promotes adipocytes inflammation by suppressing Nrf2 expression.
1,25-Dihydroxyvitamin D(3) protects against placental inflammation by suppressing NLRP3-mediated IL-1β production via Nrf2 signaling pathway in preeclampsia.
Perillaldehyde pretreatment alleviates cerebral ischemia-reperfusion injury by improving mitochondrial structure and function via the Nrf2/Keap1/Trx2 axis.
Psoralen and Isopsoralen Activate Nuclear Factor Erythroid 2-Related Factor 2 Through Interaction With Kelch-Like ECH-Associated Protein 1.
Reduction of Chemoresistance by Claudin-14-Targeting Peptide in Human Colorectal Cancer Cells.
TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis.
Effect of different dietary oil sources on the performance, egg quality and antioxidant capacity during the late laying period.
Protective Effects of α-Linolenic Acid on Liver Inflammation and Oxidative Stress Induced by Lipopolysaccharide in Broilers.
Mechanism of triiodothyronine alleviating acute alcoholic liver injury and delaying alcoholic liver fibrosis progression.
Pedunculoside inhibits cardiomyocyte inflammatory biomarkers via Nrf2/HO-1 pathway in high glucose-induced H9c2 cells and diabetic cardiomyopathy model rats.
5-(3-(N-(Carboxymethyl)naphthalene-2-sulfonamido)phenyl)-1-ethyl-1H-pyrrole-2-carboxylic acid as a Keap1-Nrf2 inhibitor for cerebral ischemia/reperfusion injury treatment.
Melanin-Deferoxamine Nanoparticles Targeting Ferroptosis Mitigate Acute Kidney Injury via RONS Scavenging and Iron Ion Chelation.
Gegen Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting Nrf2.
Saffron extract alleviates D-gal-induced late-onset hypogonadism by activating the PI3K-Akt-Nrf2 signaling pathway.
Multi-platform analysis revealed the substance basis and mechanism of Wei-Tong-Xin in ameliorating ENS dysfunction for dyspepsia treatment.
Ethyl acetate fraction of Thesium chinense Turcz. alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis mediated by activating Nrf2/SLC7A11/GPX4 axis.
Supplementation with carnosine, a food-derived bioactive dipeptide, alleviates dexamethasone-induced oxidative stress and bone impairment via the NRF2 signaling pathway.
USP38 exacerbates myocardial injury and malignant ventricular arrhythmias after ischemia/reperfusion by promoting ferroptosis through the P53/SLC7A11 pathway.
Facile Formulation of a Resveratrol-Mediated Multibond Network Hydrogel with Efficient Sustainable Antibacterial, Reactive Oxygen Species Scavenging, Pro-Angiogenesis, and Immunomodulation Activities for Accelerating Infected Wound Healing.
Solanum lycopersicum derived exosome-like nanovesicles alleviate restenosis after vascular injury through the Keap1/Nrf2 pathway.
Comprehensive Pan-Cancer Analysis and Functional Studies Reveal SLC2A6 as a Ferroptosis Modulator in Hepatocellular carcinoma.
Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens.
The therapeutic potential of Osmundacetone for rheumatoid arthritis: Effects and mechanisms on osteoclastogenesis.
Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms.
Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice.
Synthesis, evaluation and mechanism study of novel pyrazole enamides to alleviate lung injury.
The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.
Mechanism of dihydroartemisinin in the treatment of ischaemia/reperfusion-induced acute kidney injury via network pharmacology, molecular dynamics simulation and experiments.
Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies.
The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
RNA m(6)A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells.
Mechanism of P-Hydroxy Benzyl Alcohol Against Cerebral Ischemia Based on Metabonomics Analysis.
Liraglutide and GLP-1(9-37) alleviated hepatic ischemia-reperfusion injury by inhibiting ferroptosis via GSK3β/Nrf2 pathway and SMAD159/Hepcidin/FTH pathway.
Loss of Urat1 exacerbates APAP-induced liver injury in mice.
Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.
Artemisinin inhibits neuronal ferroptosis in Alzheimer's disease models by targeting KEAP1.
Rejuvenation Modulation of Nucleus Pulposus Progenitor Cells Reverses Senescence-Associated Intervertebral Disc Degeneration.
Polyphenol Mediated Assembly: Tailored Nano-Dredger Unblocks Axonal Autophagosomes Retrograde Transport Traffic Jam for Accelerated Alzheimer's Waste Clearance.
Anti-inflammatory effect of echinacoside in collagen-induced arthritis via Nrf2/Drp1 pathway.
Ophiopogon japonicus polysaccharide reduces doxorubicin-induced myocardial ferroptosis injury by activating Nrf2/GPX4 signaling and alleviating iron accumulation.
Blockade of cysteinyl leukotriene receptor 1 alleviates asthma by inhibiting bronchial epithelial cell apoptosis and activating the Nrf2 signaling pathway.
Heat exposure promotes sarcopenia via gut microbiota-derived metabolites.
Stigmasterol from Prunella vulgaris L. Alleviates LPS-induced mammary gland injury by inhibiting inflammation and ferroptosis.
Unraveling morphine tolerance: CCL2 induces spinal cord apoptosis via inhibition of Nrf2 signaling pathway and PGC-1α-mediated mitochondrial biogenesis.
Engineered Bacillus subtilis WB600/ZD prevents Salmonella Infantis-induced intestinal inflammation and alters the colon microbiota in a mouse model.
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis.
Novel therapeutic strategy: Nrf2 activation in targeting senescence-related changes in chronic obstructive pulmonary disease.
Bifidobacterium bifidum reduces oxidative stress and alters gut flora to mitigate acute liver injury caused by N-acetyl-p-aminophenol.
Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways.
Aminophylline targets miR-128-3p/Slc7a11 axis to attenuate neuronal ferroptosis after traumatic brain injury.
Targeted temperature management alleviates post-resuscitation myocardial dysfunction by inhibiting ferroptosis.
Scopoletin alleviates acetaminophen-induced hepatotoxicity through modulation of NLRP3 inflammasome activation and Nrf2/HMGB1/TLR4/NF-κB signaling pathway.
Abscisic acid improves non-alcoholic fatty liver disease in mice through the AMPK/NRF2/KEAP1 signaling axis.
Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions.
p16(INK4a) promoted progress of MCT induced pulmonary hypertension via maintaining redox balance and autophagy pathway.
Esketamine alleviates LPS-induced depression-like behavior by activating Nrf2-mediated anti-inflammatory response in adolescent mice.
Brown Algae Polysaccharides Alleviate Diquat-Induced Oxidative Stress in Piglets and IPEC-J2 Cells via Nrf2/ARE Signaling Pathway.
l-Glutamic Acid Alleviates Mastitis in Dairy Cows by Targeting the Sirt5/Nrf2/Prdx1 Signaling Axis and Mitochondrial Function.
PANAXADIOL SAPONIN ALLEVIATES LPS-INDUCED CARDIOMYOPATHY SIMILAR TO DEXAMETHASONE VIA IMPROVING MITOCHONDRIAL QUALITY CONTROL.
Puerarin reduces susceptibility to ventricular arrhythmias and inhibits ferroptosis via Sirt1/Nrf2 signaling in high-fat-diet rats.
Electroacupuncture ameliorated locomotor symptoms in MPTP-induced mice model of Parkinson's disease by regulating autophagy via Nrf2 signaling.
Nuclear factor E2 related factor 2 may alleviate liver injury by regulating iron overload and lipid peroxidation induced by chronic fluorosis.
TRPA1 activation prompts lysosome-mediated Nrf2 degradation enhancing the killing of colorectal cancer cells.
Indirubin regulates M1/M2 polarization and inhibits ferroptosis in dextran sulfate sodium induced colitis and in cultured THP-1 cells.
Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection.
SIRT6 Overexpression Enhances Diabetic Foot Ulcer Healing via Nrf2 Pathway Activation.
Maresin-1 alleviates sepsis-induced acute kidney injury by inhibiting ferroptosis via the Nrf2/HO-1/Gpx4 signaling pathway.
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Synthesis of novel pyrazole derivatives and neuroprotective effect investigation.
Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress via Sesn2/Nrf2 activation in mastitis.
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
Bilirubin-polymer nanocarriers enable targeted farrerol delivery for glaucoma neuroprotection via Nrf2-mediated ferroptosis/apoptosis inhibition.
SIRT1 inhibits ferroptosis of granulosa cells in polycystic ovarian syndrome.
Apelin-13 Attenuates Blood-Brain Barrier Dysfunction Following Intracerebral Hemorrhage via Targeting the Keap1/Nrf2 Signaling.
ACTG1 mediates cisplatin resistance in NSCLC through induction of mitochondrial fragmentation.
FASN regulates CSE-induced apoptosis, oxidative stress and mitochondrial damage in type 2 alveolar epithelial cells by regulating NRF2 expression and nuclear translocation.
ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1/Nrf2 signaling.
Oxidative stress activates the transplanted adipose-derived stem cells to exert antioxidant effects in alopecia treatment.
Flavonoids from Polypodium hastatum as neuroprotective agents attenuate cerebral ischemia/reperfusion injury in vitro and in vivo via activating Nrf2.
Overexpression of cholesterol 24-hydroxylase CYP46A1 attenuates retinal dysfunction and ganglion cell loss via regulating the Nrf2 pathway in optic nerve crush injury.
Phytic acid protects corneal endothelium from UVA induced ferroptosis.
Activation of the Nrf2/HO-1/GPX4 pathway by cGAMP Mitigates oxidative stress and ferroptosis in ischaemic stroke.
ABI3BP deficiency alleviates Ang II-induced VSMC senescence through the Nrf2 signalling pathway.
Renal tubular VMP1 protects against acute kidney injury via modulating autophagy and autophagy-independent pathway.
Unveiling the role of Jagged2 in hypoxic pulmonary arterial hypertension: A NOX2-mediated pathway.
MiR-646 inhibited cell proliferation and migration by targeting P62 in glioma.
Analysis of the Protective Mechanism of PGC-1α/NRF1/2/TFAM Pathway in Cortical Neuron Injury Induced by Oxidative Stress.
Bioactive peptides PDBSN improve mitochondrial function and suppression the oxidative stress in human adiposity cells.
Adipose-derived mesenchymal stem cell exosomes protect keratinocytes from high-glucose injury by modulating KEAP1/NRF2/HO-1 axis.
Melatonin attenuates lipopolysaccharide-induced acute myocardial injury by regulating KLF4 expression.
Unlocking the potential of garlic by-product protein: Ultrasound-induced structural modification and fabrication of an ACE inhibitory peptide targeting endothelial dysfunction.
Pituitary adenylate cyclase-activating polypeptide (PACAP) attenuates diabetic cardiomyopathy via Nrf2/HO-1 antioxidant signaling and NF-κB-mediated inflammation suppression in streptozotocin-treated mice.
Mesenchymal stem cells' exosomes alleviate chronic visceral pain through Nrf-2-mediated oxidative stress pathway in rats.
LncPEDS1-AS promotes UTUC resistance to lipid peroxidation by regulating PEDS1 expression via DDX23.
Synthesis and evaluation of lansiumamide B analogues to ameliorate acute lung injury by reducing oxidative stress and inflammation via Keap1/Nrf2/NF-κB pathway.
α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice.
Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study.
TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation.
Butin inhibits osteoarthritis progression by modulating the Nrf2/HO-1 signaling pathway and inhibiting NF-κB signaling.
Blueberry anthocyanins and their metabolites synergistically alleviated ferroptosis induced by acrylamide in HepG2 cells.
ALDH3A2 negatively orchestrates gastric cancer progression through a synergistic induction of ferroptosis and ferroptosis-driven macrophage reprogramming.
TRIM16 mediates YAP1 K63-linked ubiquitination to alleviate sepsis-induced acute liver injury through YAP/Nrf2 axis in mice.
Ferroptosis is a novel pathogenic mechanism of FDXR-related disease via disruption of the NRF2 pathway.
L-ascorbate prevents non-alcoholic steatohepatitis-based hepatocarcinogenesis in Sod1/Prdx4 double-knockout mice.
Nicotinamide riboside alleviates sepsis-induced acute kidney injury by suppressing ferroptosis.
Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis.
GSK3β-mediated NRF2 degradation drives Escherichia coli-induced ferroptosis in the bovine endometrium.
Expression and Biological Activity of Recombinant Type IV Collagen.
The Neuroprotective Effect of 4-Octyl Itaconate on Acute Period of Experimental Autoimmune Neuritis.
Sappanone A Promotes Motor Function Recovery in Spinal Cord Injury Mice by Inhibiting Microglial M1 Polarization via Activation of the Keap1/Nrf2 Pathway.
Sitagliptin inhibits neuronal ferroptosis to alleviate cognitive dysfunction by activating Nrf2-SLC7A11-GPX4 axis in diabetic mice.
Nrf2/Bach1 axis regulates redox homeostasis and energy metabolism to optimize Sertoli cell-mediated efferocytosis.
Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway.
Cuspidatyl Ferulate, a Novel Phenolic Acid from Hyssopus cuspidatus Borris, Protects Hepatocytes Against Oxidative Damage via Keap1 Interaction.
MiR-155 overexpression regulates Th1/Th2 balance by inhibiting BACH1 to activate Nrf-2/HO-1 signaling pathway in allergic rhinitis.
Competitive Binding of Pseudomonas aeruginosa to Kelch-Like ECH-Associated Protein 1 Inhibits Nuclear Factor Erythroid 2-Related Factor 2 Ubiquitination and Suppresses Ferroptosis in Macrophages.
Arbutin Preserves Boar Sperm During Storage at 17°C by Enhancing the Antioxidant Capacity via the NRF2/GPX4 Signalling.
HDAC3 Regulates Ferroptosis via Nrf2-GPX4 Signaling in Colorectal Cancer Cells.
Cadmium treatment induces oxidative damage and apoptosis in vitro skeletal muscle cells.
Titanium Particles Activate Osteocytic Connexin 43 to Induce Oxidative Stress and Osteoclastogenesis Through the JAK-STAT Pathway.
A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis.
Dietary supplementation of Lactobacillus casei alleviates permethrin exposure-induced zebrafish testis damage through modulation of TLR4/NF-κB and AKT/Nrf2 pathways: Oxidative stress, inflammation and ferroptosis.
Antroquinonol mitigates Tau hyperphosphorylation, neuronal damage and cognitive impairments in a chronic cerebral ischemia rat model.
Discovery of a novel polyketide-derived ferroptosis inhibitor from endophytic fungus Ophiobolus cirsii LZU-1509 with therapeutic potential in ischemic stroke.
Unveiling the renoprotective mechanisms of self-assembled herbal nanoparticles from Scutellaria barbata and Scleromitrion diffusum in acute kidney injury: A nano-TCM approach.
Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8-AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma.
Atractylenolide III alleviates amyloid-β-induced cognitive impairments in mice.
The foam cell-derived exosomes exacerbate ischemic white matter injury via transmitting metabolic defects to microglia.
Periplocin potentiates ferroptotic cell death in non-small cell lung cancer by inducing the degradation of Nrf2.
Novel therapeutic approach in periodontitis: Sulforaphane attenuates disease progression via Nrf2-mediated antioxidant defense.
Targeting Irgm1 to combat osteoporosis: suppressing ROS and restoring bone remodeling.
Degraded Polysaccharides from Noni (Morinda citrifolia L.) juice Mitigate Glucose Metabolism Disorders by Regulating PI3K/AKT-Nrf2-GSK3β Signaling Pathways in HepG2 Cells.
Lysionotin attenuates bleomycin-induced pulmonary fibrosis by activating AMPK/Nrf2 pathway.
Isolation and identification of a new porcine astrovirus 5 demonstrated that oxidative stress enhances porcine astrovirus replication.
Validated target-based network pharmacology reveals that salvianolic acid C attenuates doxorubicin-induced cardiotoxicity by regulating apoptosis and oxidative stress.
Luteolin attenuates trimethyltin chloride-induced hippocampal neurotoxicity through SIRT3/NRF2/HO-1 activation.
Development of Hydrogen Sulfide-Donating Silybin Derivatives with a Type-2 Diabetes Mellitus-Alleviating Effect through Improving Intestinal L-Cell Functions.
Unveiling Xuanshen decoction: A novel approach to combat slow transit constipation.
The ALDH2/PolG2 axis enhances mitochondrial biogenesis via transcriptional regulation of Nrf2 and promotes chemotherapy resistance in acute myeloid leukaemia.
Panobinostat potentiates adagrasib-induced cell death by triggering autophagy in human non-small cell lung cancer.
Dental pulp stem cells derived exosomes inhibit ferroptosis via regulating the Nrf2-keap1/GPX4 signaling pathway to ameliorate chronic kidney disease injury.
NRF2 deficiency leads to inadequate beta cell adaptation during pregnancy and gestational diabetes.
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Evidence that a Novel Chalcone Derivative, Compound 27, Acts on the Epithelium Via the PI3K/AKT/Nrf2-Keap1 Signaling Pathway, to Mitigate LPS-Induced Acute Lung Injury in Mice.
Liposomes-Loaded miR-9-5p Alleviated Hypoxia-Ischemia-Induced Mitochondrial Oxidative Stress by Targeting ZBTB20 to Inhibiting Nrf2/Keap1 Interaction in Neonatal Mice.
Thermo-sensitive ε-polylysine-heparin-poloxamer hydrogel-encapsulated BMSCs promote endometrial regeneration.
Acute hyperglycemia impedes spinal cord injury recovery via triggering excessive ferroptosis of endothelial cells.
Chlorogenic acid mitigates heat stress-induced oxidative damage in bovine mammary epithelial cells by inhibiting NF-κB-mediated NLRP3 inflammasome activation via upregulating the Nrf2 signaling pathway.
Sagittaria sagittifolia polysaccharide extract regulates Nrf2 to improve endoplasmic reticulum stress-mediated apoptosis in rat cataracts and HLEB3 cells.
MitoQ alleviates H(2)O(2)-induced mitochondrial dysfunction in keratinocytes through the Nrf2/PINK1 pathway.
Nrf2 alleviates acute ischemic stroke induced ferroptosis via regulating xCT/GPX4 pathway.
Total alkaloids from Thesium chinense inhibit lipopolysaccharide-induced respiratory inflammation by modulating Nrf2/NF-κB/NLRP3 signaling pathway.
In vivo and In vitro assessment of the retinal toxicity of polystyrene nanoplastics.
Long term exposure to multiple environmental stressors induces mitochondrial dynamics imbalance in testis: Insights from metabolomics and transcriptomics.
Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections.
p16(INK4a) Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance.
EGCG inhibits tobacco smoke-promoted proliferation of lung cancer cells through targeting CCL5.
Yinaoxin granule alleviates cerebral ischemia-reperfusion injury by ferroptosis inhibition through Nrf2 pathway activation.
Baicalin Ameliorates L-Glutamate-Induced Hippocampal Oxidative Stress Injury and Apoptosis in Mice by Regulating Nrf2/HO-1 Signalling Pathway.
Canagliflozin-induced renal glutathione distribution mapping in non-diabetic male rat kidneys.
Nrf2 Deficiency Brings About Increased Sensitive to IR and 7,12-dimethylbenz(a)anthracene and Leukemia Predisposition.
Dexmedetomidine Promotes Angiogenesis After Ischemic Stroke Through the NRF2/HO-1/VEGF Pathway.
MTCH2 regulates NRF2-mediated RRM1 expression to promote melanoma proliferation and dacarbazine insensitivity.
ELANE enhances KEAP1 protein stability and reduces NRF2-mediated ferroptosis inhibition in metabolic dysfunction-associated fatty liver disease.
Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis.
Calycosin, a Bioactive Isoflavone, Ameliorates Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Intestinal Cell Damage Model via the Nrf2 and NF-κB Signaling Pathways.
TAZ/NRF2 positive feedback loop contributes to proliferation in bladder cancer through antagonistic ferroptosis.
Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration.
Lactiplantibacillus plantarum -derived extracellular vesicles alleviate acute lung injury by inhibiting ferroptosis of macrophages.
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms.
GNF-5837 attenuates acute liver injury by inhibiting oxidative stress.
Electroacupuncture Ameliorates Chronic Inflammatory Pain and Depression Comorbidity by Inhibiting Nrf2-Mediated Ferroptosis in Hippocampal Neurons.
Regulation of the Nrf2/HO-1 pathway in chronic obstructive pulmonary disease-induced muscle atrophy using Jinshui Liujian decoction and Bajitian pills: insights from network pharmacology and animal models.
Isolation and Identification of a Novel Antioxidant Peptide from Fermented Sea Cucumber (Stichopus japonicus) Intestine and Its Protective Effects on HepG2 Cells from Oxidative Damage.
Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity.
Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management.
TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer.
Mechanism of dracorhodin in accelerating diabetic foot ulcer healing via the Nrf2 pathway, a network pharmacology, molecular docking and experimental validation.
The mitochondrial NAD transporter SLC25A51 is a modulator of beta cell senescence and type 2 diabetes.
SIRT7-mediated NRF2 deacetylation promotes antioxidant response and protects against chemodrug-induced liver injury.
Time of day differences in the regulation of glutathione levels in the rat lens.
Therapeutic potential of HUC-MSC-exos primed with IFN-γ against LPS-induced acute lung injury.
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.
CPEB1 Controls NRF2 Proteostasis and Ferroptosis Susceptibility in Pancreatic Cancer.
PRDX1 inhibits ferroptosis by binding to Cullin-3 as a molecular chaperone in colorectal cancer.
Benfotiamine protects MPTP-induced Parkinson's disease mouse model via activating Nrf2 signaling pathway.
Therapeutic potential of salidroside in type I diabetic erectile dysfunction: Attenuation of oxidative stress and apoptosis via the Nrf2/HO-1 pathway.
The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein.
Dual-Stimuli-Responsive Gut Microbiota-Targeting Nitidine Chloride-CS/PT-NPs Improved Metabolic Status in NAFLD.
Artesunate-Nanoliposome-TPP, a Novel Drug Delivery System That Targets the Mitochondria, Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Stress and Inflammatory Effects.
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats.
Exploring the Effect and Mechanism of DaYuan Yin Against Acute Lung Injury by Network Pharmacology, Molecular Docking, and Experimental Validation.
ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1.
Systematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in Osteoarthritis.
The Mechanism of Catalpol to Improve Oxidative Damage of Dermal Fibroblasts Based on Nrf2/HO-1 Signaling Pathway.
Long-term aerobic exercise improves learning memory capacity and effects on oxidative stress levels and Keap1/Nrf2/GPX4 pathway in the hippocampus of APP/PS1 mice.
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis.
Obacunone Alleviates Inflammatory Pain by Promoting M2 Microglial Polarization and by Activating Nrf2/HO-1 Signaling Pathway.
5-Methoxytryptophan Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating Nrf2-Mediated Mitophagy.
MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease.
Diosgenin derivative ML5 attenuates MPTP-induced neuronal impairment via regulating AMPK/PGC-1α-mediated mitochondrial biogenesis and fusion/fission.
Modified Buyang Huanwu Decoction alleviates diabetic liver injury via inhibiting oxidative stress in db/db mice.
miR-141-3p promotes paclitaxel resistance by attenuating ferroptosis via the Keap1-Nrf2 signaling pathway in breast cancer.
Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway.
Polydatin protects against DSS-induced ulcerative colitis via Nrf2/Slc7a11/Gpx4-dependent inhibition of ferroptosis signalling activation.
Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cells.
Tetramethylpyrazine inhibits ferroptosis in spinal cord injury by regulating iron metabolism through the NRF2/ARE pathway.
Huyang Yangkun formula regulates the mitochondria pathway of ovarian granulosa cell apoptosis through FTO/m6A-P53 pathway.
Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis.
β-cryptoxanthin suppresses oxidative stress via activation of the Nrf2/HO-1 signaling pathway in diabetic kidney disease.
A novel hollow iron nanoparticle system loading PEG-Fe(3)O(4) with C5a receptor antagonist for breast cancer treatment.
Dexmedetomidine regulates the anti-oxidation and autophagy of adipose-derived stromal cells under H(2)O(2)-induced oxidative stress through Nrf2/p62 pathway and improves the retention rate of autologous fat transplantation.
Li-Hong Tang alleviates dextran sodium sulfate-induced colitis by regulating NRF2/HO-1 signaling pathway and gut microbiota.
Protective effect of dexmedetomidine against delayed bone healing caused by morphine via PI3K/Akt mediated Nrf2 antioxidant defense system.
Cystathionine γ-lyase inhibits mitochondrial oxidative stress by releasing H(2)S nearby through the AKT/NRF2 signaling pathway.
Identification and validation of potential diagnostic signature and immune cell infiltration for HIRI based on cuproptosis-related genes through bioinformatics analysis and machine learning.
Edaravone dexborneol attenuates oxidative stress in experimental subarachnoid hemorrhage via Keap1/Nrf2 signaling pathway.
NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway.
PRMT6-mediated ADMA promotes p62 phase separation to form a negative feedback loop in ferroptosis.
Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway.
Quercetin alleviates PM(2.5)-induced chronic lung injury in mice by targeting ferroptosis.
Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress.
Identification of a novel aromatic-turmerone analog that activates chaperone-mediated autophagy through the persistent activation of p38.
Inhibition effect of copper-bearing metals on arterial neointimal hyperplasia via the AKT/Nrf2/ARE pathway in vitro and in vivo.
Antioxidant and anti-inflammatory injectable hydrogel microspheres for in situ treatment of tendinopathy.
Evaluation the protective role of baicalin against H(2)O(2)-driven oxidation, inflammation and apoptosis in bovine mammary epithelial cells.
Protective effect of short-chain fructo-oligosaccharides from chicory on alcohol-induced injury in GES-1 cells via Keap1/Nrf2 and NLRP3 inflammasome signaling pathways.
Changes of m(6)A Regulatory Proteins and Nrf2 Signaling Molecules in Liver Tissue of Type 2 Diabetes Mellitus Rats.
BSA-stabilized selenium nanoparticles ameliorate intracerebral hemorrhage's-like pathology by inhibiting ferroptosis-mediated neurotoxicology via Nrf2/GPX4 axis activation.
Tangeretin alleviates inflammation and oxidative response induced by spinal cord injury by activating the Sesn2/Keap1/Nrf2 pathway.
UBE2C regulates the KEAP1/NRF2 signaling pathway to promote the growth of gastric cancer by inhibiting autophagy.
Fucoidan alleviates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via Nrf2/GPX4 pathway.
STING1-accelerated vascular smooth muscle cell senescence-associated vascular calcification in diabetes is ameliorated by oleoylethanolamide via improved mitochondrial DNA oxidative damage.
Butylphthalide inhibits ferroptosis and ameliorates cerebral Ischaemia-Reperfusion injury in rats by activating the Nrf2/HO-1 signalling pathway.
Transcriptional regulation of Znt family members znt4, znt5 and znt10 and their function in zinc transport in yellow catfish (Pelteobagrus fulvidraco).
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression.
Therapeutic effect of nicotinamide mononucleotide on Alzheimer's disease through activating autophagy and anti-oxidative stress.
Paeonol ameliorates hyperlipidemia and autophagy in mice by regulating Nrf2 and AMPK/mTOR pathways.
Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs.
Cinnamaldehyde alleviates aspirin-induced gastric mucosal injury by regulating pi3k/akt pathway-mediated apoptosis, autophagy and ferroptosis.
Oxysophoridine inhibits oxidative stress and inflammation in hepatic fibrosis via regulating Nrf2 and NF-κB pathways.
Synthesis, Antioxidant Activity, and Molecular Docking of Novel Paeoniflorin Derivatives.
Isoquercetin Ameliorates Osteoarthritis via Nrf2/NF-κB Axis: An In Vitro and In Vivo Study.
Quercetin inhibited LPS-induced cytokine storm by interacting with the AKT1-FoxO1 and Keap1-Nrf2 signaling pathway in macrophages.
Prediction and verification of targets for α-hederin/oxaliplatin dual-loaded rHDL modified liposomes: Reversing effector T-cells dysfunction and improving anti-COAD efficiency in vitro and in vivo.
Vitamin D receptor alleviates lipid peroxidation in diabetic nephropathy by regulating ACLY/Nrf2/Keap1 pathway.
Lycium barbarum berry extract improves female fertility against aging-related oxidative stress in the ovary.
Network Analysis of Gut Microbial Communities Reveals Key Reason for Quercetin Protects against Colitis.
Aldo-Keto reductase 1C3 reduces myocardial cell damage after acute myocardial infarction by activating the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response element pathway to inhibit ferroptosis.
Activation of GABA(B)R Attenuates Intestinal Inflammation by Reducing Oxidative Stress through Modulating the TLR4/MyD88/NLRP3 Pathway and Gut Microbiota Abundance.
MMP9 drives ferroptosis by regulating GPX4 and iron signaling.
The BRD4 Inhibitor I-BET-762 Reduces HO-1 Expression in Macrophages and the Pancreas of Mice.
NBQX mediates ventricular fibrillation susceptibility in rat models of anxiety via the Nrf2/HO-1 pathway.
Time of day-dependent alterations of ferroptosis in LPS-induced myocardial injury via Bmal-1/AKT/ Nrf2 in rat and H9c2 cell.
LFHP-1c improves cognitive function after TBI in mice by reducing oxidative stress through the PGAM5-NRF2-KEAP1 ternary complex.
SIRT6 alleviates senescence induced by Porphyromonas gingivalis in human gingival fibroblasts.
Itaconic Acid Alleviates Perfluorooctanoic Acid-Induced Oxidative Stress and Intestinal Damage by Regulating the Keap1/Nrf2/Ho-1 Pathway and Reshaping the Gut Microbiota.
Dietary nitrate maintains homeostasis of oxidative stress and gut microbiota to promote flap survival in type 2 diabetes mellitus rats.
tBHQ mitigates fatty liver ischemia-reperfusion injury by activating Nrf2 to attenuate hepatocyte mitochondrial damage and macrophage STING activation.
Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis.
Apo-12'-capsorubinal exhibits anti-inflammatory effects and activates nuclear factor erythroid 2-related factor 2 in RAW264.7 macrophages.
Phytic acid-loaded polyvinyl alcohol hydrogel promotes wound healing of injured corneal epithelium through inhibiting ferroptosis.
Resveratrol Ameliorates Retinal Ischemia-Reperfusion Injury by Modulating the NLRP3 Inflammasome and Keap1/Nrf2/HO-1 Signaling Pathway.
Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia.
Cytochrome P450 F3 promotes colorectal cancer via inhibiting NRF2-mediated ferroptosis.
Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway.
Berberine Inhibits Ferroptosis and Stabilizes Atherosclerotic Plaque through NRF2/SLC7A11/GPX4 Pathway.
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator-activated receptor gamma.
Prebiotic stachyose inhibits PRDX5 activity and castration-resistant prostate cancer development.
7,8-DHF inhibits BMSC oxidative stress via the TRKB/PI3K/AKT/NRF2 pathway to improve symptoms of postmenopausal osteoporosis.
Thiols-rich peptide from water buffalo horn keratin alleviates oxidative stress and inflammation through co-regulating Nrf2/Hmox-1 and NF-κB signaling pathway.
PLK2-mediated phosphorylation of SQSTM1 S349 promotes aggregation of polyubiquitinated proteins upon proteasomal dysfunction.
Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway.
Wnt/β-catenin signaling inhibits oxidative stress-induced ferroptosis to improve interstitial cystitis/bladder pain syndrome by reducing NF-κB.
Bombesin protects myocardium against ischemia/reperfusion injury via activation of the Keap1-Nrf2-HO-1 signaling pathway.
Sulforaphane improves post-resuscitation myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the Nrf2/IRF1/GPX4 pathway.
Propofol pretreatment inhibits ferroptosis and alleviates myocardial ischemia-reperfusion injury through the SLC16A13-AMPK-GPX4 pathway.
Artemether ameliorates acetaminophen-induced liver injury through Nrf2 pathway.
Ganweikang extract protects hepatocytes from oxidative injury by activating Nrf2/HO-1 and MAPKs pathways.
The effects of BMP2 and the mechanisms involved in the invasion and angiogenesis of IDH1 mutant glioma cells.
Liver protects neuron viability and electrocortical activity in post-cardiac arrest brain injury.
Schisandra chinensis lignans regulate and cooperate with endogenous cannabinoid systems to ameliorate intestinal barrier injury associated with depression.
Phenylpropanoid-rich maize root extract serves as a natural antidepressant.
Nrf2 deficiency exacerbated pulmonary pyroptosis in maternal hypoxia-induced intrauterine growth restriction offspring mice.
Human umbilical cord mesenchymal stem cells-derived exosomes attenuate burn-induced acute lung injury via inhibiting ferroptosis.
Orientin promotes diabetic wounds healing by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
4-Octyl itaconate promotes alveolar ridge preservation following tooth extraction.
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac Injury through Maintaining SLC25A10-Mediated Mitochondrial Glutathione Import.
Dietary ferulic acid supplementation enhances antioxidant capacity and alleviates hepatocyte pyroptosis in diquat challenged piglets.
Ozone therapy mitigates parthanatos after ischemic stroke.
Wogonin mitigates acetaminophen-induced liver injury in mice through inhibition of the PI3K/AKT signaling pathway.
ML385, an Nrf2 Inhibitor, Synergically Enhanced Celastrol Triggered Endoplasmic Reticulum Stress in Lung Cancer Cells.
Antioxidant 1,2,3,4,6-Penta-O-galloyl-β-D-glucose Alleviating Apoptosis and Promoting Bone Formation Is Associated with Estrogen Receptors.
Essential oil from Chimonanthus nitens Oliv. Leaves ameliorate inflammation and oxidative stress in LPS-induced ALI through NF-κB and Nrf2 signaling pathways.
Ellagic Acid Reduces Cadmium Exposure-Induced Apoptosis in HT22 Cells via Inhibiting Oxidative Stress and Mitochondrial Dysfunction and Activating Nrf2/HO-1 Pathway.
The Protective Effects of Polygala tenuifolia and Tenuifolin on Corticosterone-Evoked Ferroptosis, Oxidative Stress, and Neuroinflammation: Insights from Molecular Dynamics Simulations and In Vitro Experiments.
Tetramethylpyrazine Analogue T-006 Protects Neuronal and Endothelial Cells Against Oxidative Stress via PI3K/AKT/mTOR and Nrf2 Signaling.
Role of iron homeostasis in the mutagenicity of disinfection by-products in mammalian cells.
Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study.
CD8+ T cell associated scoring model helps prognostic diagnosis and immunotherapy selection in patients with colon adenocarcinoma.
Mitochondrial disruption resulting from Cepharanthine-mediated TOM inhibition triggers ferroptosis in colorectal cancer cells.
Comparative Study of an Antioxidant Compound and Ethoxyquin on Feed Oxidative Stability and on Performance, Antioxidant Capacity, and Intestinal Health in Starter Broiler Chickens.
Licochalcone A Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load and Activating the Nrf2/HO-1 Signaling Pathway.
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice.
Rituximab induces ferroptosis and RSL3 overcomes rituximab resistance in diffuse large B-cell lymphoma cells.
Treatment with a combination of myricitrin and exercise alleviates myocardial infarction in rats via suppressing Nrf2/HO-1 antioxidant pathway.
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury.
The single-cell transcriptomic landscape of the topological differences in mammalian auditory receptors.
Nrf2 deficiency in muscle attenuates experimental autoimmune myositis-induced muscle weakness.
CBR-470-1 protects against cardiomyocyte death in ischaemia/reperfusion injury by activating the Nrf2-GPX4 cascade.
HADH suppresses clear cell renal cell carcinoma progression through reduced NRF2-dependent glutathione synthesis.
A two-pronged approach to inhibit ferroptosis of MSCs caused by the iron overload in postmenopausal osteoporosis and promote osseointegration of titanium implant.
Silver Nanoparticles Loaded With Oleuropein Alleviates LPS-Induced Acute Lung Injury by Modulating the TLR4/P2X7 Receptor-Mediated Inflammation and Apoptosis in Rats.
Ferulic Acid Protects Human Lens Epithelial Cells Against UVA-Induced Oxidative Damage by Downregulating the DNA Demethylation of the Keap1 Promoter.
Ginkgo Flavone Aglycone Ameliorates Atherosclerosis via Inhibiting Endothelial Pyroptosis by Activating the Nrf2 Pathway.
Mechanical Stress-Oxidative Stress Axis: Biological Basis in the Vaginal Wall and Pelvic Floor Muscles of Rats with Simulated Birth Injury.
Metformin attenuates PM(2.5)-induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells.
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
Lycium barbarum polysaccharides (LBP) suppresses hypoxia/reoxygenation (H/R)-induced rat H9C2 cardiomyocytes pyroptosis via Nrf2/HO-1 signaling pathway.
Hepatocyte-Specific HuR Protects Against Acetaminophen-Induced Liver Injury in Mice.
Oleocanthal mitigates CoCl(2)-induced oxidative damage and apoptosis via regulating MAPK pathway in human retinal pigment epithelial cells.
Buparlisib and ponatinib inhibit aggressiveness of cholangiocarcinoma cells via suppression of IRS1-related pathway by targeting oxidative stress resistance.
APMCG-1 attenuates ischemic stroke injury by reducing oxidative stress and apoptosis and promoting angiogenesis via activating PI3K/AKT pathway.
Effects of diet-induced metabolic syndrome on cardiac function and angiogenesis in response to the sodium-glucose cotransporter-2 inhibitor canagliflozin.
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model.
Mn(II)-Aloe-Emodin Nanoscale Coordination Polymer Enhances Ferroptosis by Synergistically Enhancing Reactive Oxygen Species Generation via the Nrf2-GPX4 Axis.
Human placental mesenchymal stromal cells alleviate intestinal oxidative damage in mice with graft-versus-host disease via CD73/adenosine/PI3K/Akt/GSK-3β axis.
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Oxidised rice bran oil induced oxidative stress and apoptosis in IPEC-J2 cells via the Nrf2 signalling pathway.
ML385 promotes ferroptosis and radiotherapy sensitivity by inhibiting the NRF2-SLC7A11 pathway in esophageal squamous cell carcinoma.
GDF15 attenuates sepsis-induced myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the SOCS1/GPX4 signaling pathway.
cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy.
The Effect of Meloxicam on Inflammatory Response and Oxidative Stress Induced by Klebsiella pneumoniae in Bovine Mammary Epithelial Cells.
Ciprofol prevents ferroptosis in LPS induced acute lung injury by activating the Nrf2 signaling pathway.
Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion.
Oncogenic RTKs sensitize cancer cells to ferroptosis via c-Myc mediated upregulation of ACSL4.
Trehalose Alleviates D-Galactose-Induced Aging-Related Granulosa Cell Death in Ovaries.
Increased splicing of CXCR3 isoform B (CXCR3B) by impaired NRF2 signaling leads to melanocyte apoptosis in active vitiligo.
Renal microRNA-144-3p is associated with transforming growth factor-β1-induced oxidative stress and fibrosis by suppressing the NRF2 pathway in hypertensive diabetic kidney disease.
Mesenchymal stromal cells deliver H(2)S-enhanced Nrf2 via extracellular vesicles to mediate mitochondrial homeostasis for repairing hypoxia-ischemia brain damage.
Therapeutic potential of plasma-treated solutions in atopic dermatitis.
Biliverdin improved angiogenesis and suppressed apoptosis via PI3K/Akt-mediated Nrf2 antioxidant system to promote ischemic flap survival.
Therapeutic potential of omaveloxolone in counteracting muscle atrophy post-denervation: a multi-omics approach.
Tripartite motif 25 inhibits protein aggregate degradation during PRRSV infection by suppressing p62-mediated autophagy.
Asperuloside activates hepatic NRF2 signaling to stimulate mitochondrial metabolism and restore lipid homeostasis in high fat diet-induced MAFLD.
Cobalt nanoparticles attenuate microplastic-induced vascular endothelial injury via Nrf2 pathway activation.
Trimethylamine Induced Chronic Kidney Injury by Activating the ZBP1-NLRP3 Inflammasome Pathway.
Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis.
Design, synthesis and biological evaluation of N-salicyloyl tryptamine derivatives as multifunctional neuroprotectants for the treatment of ischemic stroke.
Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-κB and Nrf2 signaling pathways.
SIRT5 participates in the suppressive tumor immune microenvironment of EGFR-mutant LUAD by regulating the succinylation of ACAT1.
Dexmedetomidine preconditioning attenuates ferroptosis in myocardial ischemia-reperfusion injury via α2 adrenergic receptor activation.
Discovery of Propionic Acid Derivatives with a 5-THIQ Core as Potent and Orally Bioavailable Keap1-Nrf2 Protein-Protein Interaction Inhibitors for Acute Kidney Injury.
osa-miR168a, a Plant miRNA That Survives the Process of In Vivo Food Digestion, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice by Oral Administration.
Protective role of aconitate decarboxylase 1 in neuroinflammation-induced dysfunctions of the paraventricular thalamus and sleepiness.
Loss of Nrf2 aggravates ionizing radiation-induced intestinal injury by activating the cGAS/STING pathway via Pirin.
Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoids in lipopolysaccharide-treated HEI-OC1 cells through modulation of the FOXP3/Nrf2 signaling pathway.
Treatment of Parkinson's disease model with human umbilical cord mesenchymal stem cell-derived exosomes loaded with BDNF.
Oral edaravone ameliorates behavioral deficits and pathologies in a valproic acid-induced rat model of autism spectrum disorder.
Gaudichaudione H ameliorates liver fibrosis and inflammation by targeting NRF2 signaling pathway.
Unconjugated bilirubin promotes uric acid restoration by activating hepatic AMPK pathway.
Hydrogen sulfide upregulates SIRT1 to inhibit ox-HDL-induced endothelial cell damage and mitochondrial dysfunction.
Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant Non-Small Cell Lung Cancer.
An RGD-Conjugated Prodrug Nanoparticle with Blood-Brain-Barrier Penetrability for Neuroprotection Against Cerebral Ischemia-Reperfusion Injury.
Identification of ROS and KEAP1-related genes and verified targets of α-hederin induce cell death for CRC.
Sodium butyrate alleviates experimental autoimmune prostatitis by inhibiting oxidative stress and NLRP3 inflammasome activation via the Nrf2/HO-1 pathway.
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species.
Resveratrol ameliorates ulcerative colitis by upregulating Nrf2/HO‑1 pathway activity: Integrating animal experiments and network pharmacology.
Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress.
Lotus Leaf Extract Alleviates Lipopolysaccharide-Induced Intestinal Injury in Mice by Regulating Oxidative Stress and Inflammation.
Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling.
Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing.
Indole-3-carbinol ameliorates ovarian damage in female old mice through Nrf2/HO-1 pathway activation.
Resveratrol alleviates inorganic arsenic-induced ferroptosis in chicken brain via activation of the Nrf2 signaling pathway.
Mastoparan M promotes functional recovery in stroke mice by activating autophagy and inhibiting ferroptosis.
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Aucubin alleviates doxorubicin-induced cardiotoxicity through crosstalk between NRF2 and HIPK2 mediating autophagy and apoptosis.
Protective effects of sodium humate and its zinc and selenium chelate on the oxidative stress, inflammatory, and intestinal barrier damage of Salmonella Typhimurium-challenged broiler chickens.
A Japanese herbal medicine (kampo), hochuekkito (TJ-41), has anti-inflammatory effects on the chronic obstructive pulmonary disease mouse model.
Molecular, biological characterization and drug sensitivity of chidamide-resistant MCF7 cells.
LC-MS-based rheumatoid arthritis serum metabolomics reveals the role of deoxyinosine in attenuating collagen-induced arthritis in mice.
Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis.
ABI3BP promotes renal aging through Klotho-mediated ferroptosis.
Disease-modifying potential of diphenyl diselenide in an experimental osteoarthritis model.
Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis.
Mapping the tumor stress network reveals dynamic shifts in the stromal oxidative stress response.
FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control.
Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.
Phosphatidylserine Counteracts the High Stocking Density-Induced Stress Response, Redox Imbalance and Immunosuppression in Fish Megalobrama ambylsephala.
Chondrocyte-targeted exosome-mediated delivery of Nrf2 alleviates cartilaginous endplate degeneration by modulating mitochondrial fission.
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury.
A recombinant plasmid encoding human hepatocyte growth factor promotes healing of combined radiation-trauma skin injury involved in regulating Nrf2 pathway in mice.
Lizhong decoction ameliorates ulcerative colitis by inhibiting ferroptosis of enterocytes via the Nrf2/SLC7A11/GPX4 pathway.
Local Application of Tanshinone IIA protects mesenchymal stem cells from apoptosis and promotes fracture healing in ovariectomized mice.
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway.
Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways.
PPARγ Antagonists Exhibit Antitumor Effects by Regulating Ferroptosis and Disulfidptosis.
The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis.
Protecting effects of 4-octyl itaconate on neonatal hypoxic-ischemic encephalopathy via Nrf2 pathway in astrocytes.
Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways.
Involvement of ferroptosis in eribulin-induced cytotoxicity in ovarian clear cell carcinoma.
FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway.
Effects of KEAP1 Silencing on NRF2 and NOTCH Pathways in SCLC Cell Lines.
Effects of Pemafibrate on Reducing Oxidative Stress and Augmenting Angiogenesis in Ischemic Limb Tissue.
CDDO, an Anti-Inflammatory and Antioxidant Compound, Attenuates Vasospasm and Neuronal Cell Apoptosis in Rats Subjected to Experimental Subarachnoid Hemorrhage.
Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.
Cytotoxic withanolides from the stems and leaves of Physalis ixocarpa.
Edaravone dexborneol protects against cerebral ischemia/reperfusion-induced blood-brain barrier damage by inhibiting ferroptosis via activation of nrf-2/HO-1/GPX4 signaling.
Involvement of the Keap1-Nrf2-ARE pathway in the antioxidant activity of sinomenine.
Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway.
RTA-408 Regulates p-NF-κB/TSLP/STAT5 Signaling to Ameliorate Nociceptive Hypersensitivity in Chronic Constriction Injury Rats.
Quercetin-3-O-β-D-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation.
Protective Effects of Hinokitiol on Neuronal Ferroptosis by Activating the Keap1/Nrf2/HO-1 Pathway in Traumatic Brain Injury.
Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy.
Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway.
Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.
Electroacupuncture Attenuates Ventilator-Induced Lung Injury by Modulating the Nrf2/HO-1 Pathway.
Rhizoma Paridis saponins attenuate Gram-negative bacteria-induced inflammatory acne by binding to KEAP1 and modulating Nrf2 and MAPK pathways.
Intermittent hypoxia induces hepatic senescence through promoting oxidative stress in a mouse model.
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei.
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer.
Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury.
ADSC-Exos enhance functional recovery after spinal cord injury by inhibiting ferroptosis and promoting the survival and function of endothelial cells through the NRF2/SLC7A11/GPX4 pathway.
Nrf-2/ROS/NF-κB pathway is modulated by cynarin in human mesenchymal stem cells in vitro from ankylosing spondylitis.
Retinoic acid alleviates rotavirus-induced intestinal damage by regulating redox homeostasis and autophagic flux in piglets.
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy.
LuQi formula attenuates Cardiomyocyte ferroptosis via activating Nrf2/GPX4 signaling axis in heart failure.
Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity.
Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis.
VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy.
Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice.
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats.
Methylmercury Induces Apoptosis in Mouse C17.2 Neural Stem Cells through the Induction of OSGIN1 Expression by NRF2.
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx.
Mechanism of Porphyra Yezoensis Polysaccharides in Inhibiting Hyperoxalate-Induced Renal Injury and Crystal Deposition.
Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway.
A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver.
Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2.
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.
Bi(2)S(3)/Ti(3)C(2)-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors.
Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway.
Anti-inflammatory and anti-oxidative electrospun nanofiber membrane promotes diabetic wound healing via macrophage modulation.
Pentoxifylline protects against cerebral ischaemia-reperfusion injury through ferroptosis regulation via the Nrf2/SLC7A11/GPX4 signalling pathway.
Identifying key antioxidative stress factors regulating Nrf2 in the genioglossus with human umbilical cord mesenchymal stem-cell therapy.
SAP130 released by ferroptosis tubular epithelial cells promotes macrophage polarization via Mincle signaling in sepsis acute kidney injury.
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis.
Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis.
4-Octyl Itaconate Inhibits Proinflammatory Cytokine Production in Behcet's Uveitis and Experimental Autoimmune Uveitis.
PHPB ameliorates memory deficits and reduces oxidative injury in Alzheimer's disease mouse model by activating Nrf2 signaling pathway.
Bicyclol Alleviates Streptozotocin-induced Diabetic Cardiomyopathy By Inhibiting Chronic Inflammation And Oxidative Stress.
An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy.
An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness.
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Total flavonoids of Broussonetia papyrifera alleviate non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signaling pathways.
Dihydromyricetin regulates KEAP1-Nrf2 pathways to enhance the survival of ischemic flap.
Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.
Homotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases.
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
ROS Induced by Aphrocallistes vastus Lectin Enhance Oncolytic Vaccinia Virus Replication and Induce Apoptosis in Hepatocellular Carcinoma Cells.
Isorhamnetin alleviates ferroptosis-mediated colitis by activating the NRF2/HO-1 pathway and chelating iron.
Nicotine promotes Staphylococcus aureus-induced osteomyelitis by activating the Nrf2/Slc7a11 signaling axis.
Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.
PPIA dictates NRF2 stability to promote lung cancer progression.
Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway.
Mechanistic studies on the alleviation of ANIT-induced cholestatic liver injury by Polygala fallax Hemsl. polysaccharides.
Bradykinin induces acute kidney injury after hypothermic circulatory arrest through the repression of the Nrf2-xCT pathway.
Fucoxanthin alleviates lipopolysaccharide-induced intestinal barrier injury in mice.
Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload.
Involvement of P2X7R-mediated microglia polarization and neuroinflammation in the response to electroacupuncture on post-stroke memory impairment.
X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway.
FGF10 protects against particulate matter-induced lung injury by inhibiting ferroptosis via Nrf2-dependent signaling.
Electrical Pulse Stimulation Protects C2C12 Myotubes against Hydrogen Peroxide-Induced Cytotoxicity via Nrf2/Antioxidant Pathway.
Alantolactone attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease.
N -N-Butyl Haloperidol Iodide Mitigates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1-Nrf2 Signaling Loop.
Docosahexaenoic Acid Coordinating with Sodium Selenite Promotes Paraptosis in Colorectal Cancer Cells by Disrupting the Redox Homeostasis and Activating the MAPK Pathway.
Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway.
DACH1 Attenuates Airway Inflammation in Chronic Obstructive Pulmonary Disease by Activating NRF2 Signaling.
Conditional Knockout of IL-1R1 in Endothelial Cells Attenuates Seizures and Neurodegeneration via Inhibiting Neuroinflammation Mediated by Nrf2/HO-1/NLRP3 Signaling in Status Epilepticus Model.
Selenium nanoparticles decorated with polysaccharides from Sargassum fusiforme protects against 6-OHDA-induced neurotoxicity in PC12 cells and rat model of Parkinson's disease.
Protective effect of Cyclo(His-Pro) on peritoneal fibrosis through regulation of HDAC3 expression.
PEDF and 34-mer peptide inhibit cardiac microvascular endothelial cell ferroptosis via Nrf2/HO-1 signalling in myocardial ischemia-reperfusion injury.
Magnolol against enterovirus 71 by targeting Nrf2-SLC7A11-GSH pathway.
Pinocembrin's protective effect against acute pancreatitis in a rat model: The correlation between TLR4/NF-κB/NLRP3 and miR-34a-5p/SIRT1/Nrf2/HO-1 pathways.
Chemopreventive effects of atractylenolide-III on mammary tumorigenesis via activation of the Nrf2/ARE pathway through autophagic degradation of Keap1.
Berberine synergises with ferroptosis inducer sensitizing NSCLC to ferroptosis in p53-dependent SLC7A11-GPX4 pathway.
Duodenal-jejunal bypass surgery activates eNOS and enhances antioxidant system by activating AMPK pathway to improve heart oxidative stress in diabetic cardiomyopathy rats.
EZH2 suppresses ferroptosis in hepatocellular carcinoma and reduces sorafenib sensitivity through epigenetic regulation of TFR2.
PXR Activation Relieves Deoxynivalenol-Induced Liver Oxidative Stress Via Malat1 LncRNA m(6)A Demethylation.
Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway.
Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model.
Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1.
Inhibition of insulin degrading enzyme suppresses osteoclast hyperactivity via enhancing Nrf2-dependent antioxidant response in glucocorticoid-induced osteonecrosis of the femoral head.
Paeoniflorin Promotes Ovarian Development in Mice by Activating Mitophagy and Preventing Oxidative Stress.
The EGR1/miR-139/NRF2 axis orchestrates radiosensitivity of non-small-cell lung cancer via ferroptosis.
Icariin alleviates cisplatin-induced premature ovarian failure by inhibiting ferroptosis through activation of the Nrf2/ARE pathway.
Baicalin promotes the sensitivity of NSCLC to cisplatin by regulating ferritinophagy and macrophage immunity through the KEAP1-NRF2/HO-1 pathway.
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress.
Targeting the smooth muscle cell KEAP1-Nrf2-STING axis with pterostilbene attenuates abdominal aortic aneurysm.
Salvianolic acid B protects against UVB-induced skin aging via activation of NRF2.
Linoleic Acid Alleviates Lipopolysaccharide Induced Acute Liver Injury via Activation of Nrf2.
ZIF-8-based Nanoparticles for Inflammation Treatment and Oxidative Stress Reduction in Periodontitis.
Single-cell RNA sequencing reveals that NRF2 regulates vascular smooth muscle cell phenotypic switching in abdominal aortic aneurysm.
Zearalenone modulates the function of goat endometrial cells via the mitochondrial quality control system.
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
Novel Inhibitor of Keap1-Nrf2 Protein-Protein Interaction Attenuates Osteoclastogenesis In Vitro and Prevents OVX-Induced Bone Loss In Vivo.
Lung decellularized matrix-derived 3D spheroids: Exploring silicosis through the impact of the Nrf2/Bax pathway on myofibroblast dynamics.
Bacillus cereus CwpFM induces colonic tissue damage and inflammatory responses through oxidative stress and the NLRP3/NF-κB pathway.
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
Plasma-activated medium ameliorates the chemoresistance of human lung adenocarcinoma cells mediated via downregulation of claudin-2 expression.
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Empagliflozin reduces endoplasmic reticulum stress associated TXNIP/NLRP3 activation in tunicamycin-stimulated aortic endothelial cells.
The cyclin-dependent kinase inhibitor abemaciclib-induced hepatotoxicity: Insight on the molecular mechanisms in HepG2/THP-1 co-culture model.
Taxifolin-mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of glucocorticoid-induced osteonecrosis of the femoral head.
TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling.
Mitochondria-targeted cerium vanadate nanozyme suppressed hypoxia-ischemia injury in neonatal mice via intranasal administration.
Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling.
Berberine alleviates contrast-induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway.
Chronic restraint stress induces abnormal behaviors in pain sensitivity and cognitive function in mice: the role of Keap1/Nrf2 pathway.
KAN0438757, a novel PFKFB3 inhibitor, prevent the progression of severe acute pancreatitis via the Nrf2/HO-1 pathway in infiltrated macrophage.
Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.
Isoliquiritigenin inhibits apoptosis and ameliorates oxidative stress in rheumatoid arthritis chondrocytes through the Nrf2/HO-1-mediated pathway.
Chlorogenic acid attenuates deoxynivalenol-induced apoptosis and pyroptosis in human keratinocytes via activating Nrf2/HO-1 and inhibiting MAPK/NF-κB/NLRP3 pathways.
Improvement of sea buckthorn (Hippophae rhamnoides L.) flavonoids on the antioxidant and immune performance of Yellow River carp (Cyprinus carpio L.) fed high-carbohydrate diet.
EGFR/MAPK signaling pathway acts as a potential therapeutic target for sulforaphane-rescued heart tube malformation induced by various concentrations of PhIP exposure.
Intranasal delivery of macrophage cell membrane cloaked biomimetic drug-nanoparticle system attenuates acute lung injury.
Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer.
Near-infrared-responsive GE11-CuS@Gal nanoparticles as an intelligent drug release system for targeting therapy against oral squamous cell carcinoma.
Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells.
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
Integrated analysis of metabolomic and transcriptomic profiling reveals the effect of Atractylodes oil on Spleen Yang Deficiency Syndrome in rats.
Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway.
Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14/Keap1/Nrf2 pathway.
Treadmill exercise can regulate the redox balance in the livers of APP/PS1 mice and reduce LPS accumulation in their brains through the gut-liver-kupffer cell axis.
Taurine Chloramine-Mediated Nrf2 Activation and HO-1 Induction Confer Protective Effects in Astrocytes.
Antioxidative Sirt1 and the Keap1-Nrf2 Signaling Pathway Impair Inflammation and Positively Regulate Autophagy in Murine Mammary Epithelial Cells or Mammary Glands Infected with Streptococcus uberis.
Malvidin promotes PGC-1α/Nrf2 signaling to attenuate the inflammatory response and restore mitochondrial activity in septic acute kidney injury.
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Activation of sigma-1 receptor ameliorates sepsis-induced myocardial injury by mediating the Nrf2/HO1 signaling pathway to attenuate mitochondrial oxidative stress.
Liensinine alleviates mouse intestinal injury induced by sepsis through inhibition of oxidative stress, inflammation, and cell apoptosis.
Bardoxolone methyl breaks the vicious cycle between M1 macrophages and senescent nucleus pulposus cells through the Nrf2/STING/NF-κB pathway.
Prothymosin α accelerates dengue virus-induced thrombocytopenia.
Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets.
The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin.
Neutrophil extracellular trap-related mechanisms in acne vulgaris inspire a novel treatment strategy with adipose-derived stem cells.
Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis.
Modified Qing-Zao-Jiu-Fei decoction attenuated pulmonary fibrosis induced by bleomycin in rats via modulating Nrf2/NF-κB and MAPKs pathways.
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes.
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Integrated proteomics and metabolomics reveals metabolism disorders in the α-syn mice and potential therapeutic effect of Acanthopanax senticosus extracts.
Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway.
Costunolide attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease.
4-octyl itaconate ameliorates ventilator-induced lung injury.
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.
Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma.
Targeting Ferroptosis Promotes Functional Recovery by Mitigating White Matter Injury Following Acute Carbon Monoxide Poisoning.
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3β-Nrf2 signal cascade.
hPMSCs Regulate the Level of TNF-α and IL-10 in Th1 Cells and Improve Hepatic Injury in a GVHD Mouse Model via CD73/ADO/Fyn/Nrf2 Axis.
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.
Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway.
Epigallocatechin-3-gallate promotes wound healing response in diabetic mice by activating keratinocytes and promoting re-epithelialization.
Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: From mechanism to therapy.
Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice.
4-octyl itaconate protects against oxidative stress-induced liver injury by activating the Nrf2/Sirt3 pathway through AKT and ERK1/2 phosphorylation.
Dimerized sesquiterpenoid [4 + 2] adducts with ferroptosis-promoting activity from Inula britannica Linn.
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
Fructus Ligustri Lucidi inhibits ferroptosis in ovariectomy‑induced osteoporosis in rats via the Nrf2/HO‑1 signaling pathway.
Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
Downregulation of TET2 Contributes to Nasal Polypogenesis Through Hypoxia-Inducible Factor 1α-Mediated Epithelial-to-Mesenchymal Transition.
Characteristic alkaloids from Stemona sessilifolia with lung protective effects.
Gut microbiome-based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from Selaginella uncinata (Desv.) Spring against inflammatory bowel disease.
Apigenin promotes apoptosis of 4T1 cells through PI3K/AKT/Nrf2 pathway and improves tumor immune microenvironment in vivo.
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
4-amino-2-trifluoromethyl-phenyl retinate alleviates lipopolysaccharide-induced acute myocardial injury through activation of the KLF4/p62 axis.
Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling.
Catalpol Promotes Osseointegration of Titanium Implants under Conditions of Type 2 Diabetes via AKT/GSK3β/FYN Pathway-Mediated NRF2 Activation.
Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway.
Rapid Discovery of Aβ(42) Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer's Disease.
Chemical Characterization of Honeysuckle Polyphenols and Their Alleviating Function on Ultraviolet B-Damaged HaCaT Cells by Modulating the Nrf2/NF-κB Signaling Pathways.
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC.
Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice.
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
The neuroprotective effect of LCZ696 on methamphetamine-induced cognitive impairment in mice.
Isofraxidin attenuates dextran sulfate sodium-induced ulcerative colitis through inhibiting pyroptosis by upregulating Nrf2 and reducing reactive oxidative species.
Gamma-oryzanol alleviates osteoarthritis development by targeting Keap1-Nrf2 binding to interfere with chondrocyte ferroptosis.
1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature.
Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation.
Fluorescent gold nanoclusters possess multiple actions against atherosclerosis.
Pharmacological USP2 targeting suppresses ovarian cancer growth by potentiating apoptosis and ferroptosis.
Inhibition of CDGSH iron‑sulfur domain 2 exhibits tumor-suppressing effects on diffuse large B-cell lymphoma (DLBCL) by inducing ferroptosis through the regulation of the NRF2/SLC7A11/GPX4 pathway.
TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2.
Reserpine alleviates cisplatin-induced acute kidney injury via anti-ferroptosis and cGAS/STING pathway.
Chrysophanol-mediated trx-1 activation attenuates renal fibrosis through inhibition of the JNK/Cx43 signaling pathway.
Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway.
Nanoparticles transfected with plasmid-encoded lncRNA-OIP5-AS1 inhibit renal ischemia-reperfusion injury in mice via the miR-410-3p/Nrf2 axis.
CircYTHDF1/miR-19b-3p/YTHDF1 axis contributes to pregnancy-induced hypertension development by enhancing vascular endothelial cell injury.
Exposure to Polypropylene Microplastics Causes Cardiomyocyte Apoptosis Through Oxidative Stress and Activation of the MAPK-Nrf2 Signaling Pathway.
Rivaroxaban Combined with Atorvastatin Inhibits Acute Pulmonary Embolism by Promoting the Expression of NRF2/NQO1.
Procyanidin B1 Promotes PSMC3-NRF2 Ubiquitination to Induce Ferroptosis in Glioblastoma.
Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway.
Regulation of LAMTOR1 by oxidative stress in retinal pigment epithelium: Implications for age-related macular degeneration pathogenesis.
Sulforaphane acts through the NFE2L2/AMPK signaling pathway to protect boar spermatozoa from cryoinjury by activating antioxidant defenses.
Oleanolic acid promotes porcine oocyte maturation by activating the Nrf2/HO-1 signalling pathway.
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
Protective Effect of Acteoside against Hydrogen Peroxide-Induced Oxidative Damage in Human Corneal Epithelial Cells.
Baliosperoid A attenuates lipopolysaccharide-induced acute lung injury by targeting SHP2 to inhibit inflammation and oxidative stress.
Discovery of novel 5-phenyl-1H-pyrrole-2-carboxylic acids as Keap1-Nrf2 inhibitors for acute lung injury treatment.
Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway.
Dang-Gui-Bu-Xue decoction against diabetic nephropathy via modulating the carbonyl compounds metabolic profile and AGEs/RAGE pathway.
Osmundacetone ameliorates Alzheimer's-like pathologies by inhibiting β-amyloid fibrillation, oxidative damage and neuroinflammation in APP/PS1 transgenic mice.
Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway.
Inhibition of ubiquitin-specific protease 7 ameliorates ferroptosis-mediated myocardial infarction by contrasting oxidative stress: An in vitro and in vivo analysis.
Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC-1α-mediated Transcriptional Coactivation.
Role of hypoxia-inducible-factor-1α (HIF-1α) in ferroptosis of adipose tissue during ketosis.
Dietary Bacillus subtilis benefits meat quality by regulating the muscle fiber type and antioxidant capacity of broilers.
Spatheliachromen mitigates methylglyoxal-induced myotube atrophy by activating Nrf2, inhibiting ubiquitin-mediated protein degradation, and restoring mitochondrial function.
Gypenoside A-loaded mPEG-PLGA nanoparticles ameliorate high-glucose-induced retinal microvasculopathy by inhibiting ferroptosis.
Investigating the potential risk of cadmium exposure on seizure severity and anxiety-like behaviors through the ferroptosis pathway in epileptic mice: An integrated multi-omics approach.
Albiflorin inhibits osteoclastogenesis and titanium particles-induced osteolysis via inhibition of ROS accumulation and the PI3K/AKT signaling pathway.
Triphala ameliorates cognitive deficits and anxiety via activation of the Nrf2/HO-1 axis in chronic sleep-deprived mice.
Corydaline attenuates osteolysis in rheumatoid arthritis via mitigating reactive oxygen species production and suppressing calcineurin-Nfatc1 signaling.
Cardioprotective effect of Saussurea involucrata injection against Doxorubicin-induced cardiotoxicity by network pharmacology analysis and experimental verification.
Prevention of bleomycin-induced pulmonary fibrosis by vaccination with the Tocilizumab mimotope.
Colon-targeted engineered postbiotics nanoparticles alleviate osteoporosis through the gut-bone axis.
CRL3(Keap1) E3 ligase facilitates ubiquitin-mediated degradation of oncogenic SRX to suppress colorectal cancer progression.
Screening of orthopedic medicines identifies raloxifene hydrochloride as a novel ferroptosis inhibitor for spinal cord injury therapy.
Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects.
Nicotinamide adenine dinucleotide phosphate alleviates intestinal ischemia/reperfusion injury via Nrf2/HO-1 pathway.
Ruscogenin attenuates osteoarthritis by modulating oxidative stress-mediated macrophage reprogramming via directly targeting Sirt3.
Isolicoflavonol ameliorates acute liver injury via inhibiting NLRP3 inflammasome activation through boosting Nrf2 signaling in vitro and in vivo.
African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation.
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
1,2-Propanediol Attenuates Radiation-Induced HaCaT Cell Injury by Inhibiting Oxidative Stress.
Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro.
Effects of Bifidobacterium and rosuvastatin on metabolic-associated fatty liver disease via the gut-liver axis.
myCAF-derived exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment.
Carbon dots encapsulated zeolitic imidazolate framework-8 as an enhanced multi-antioxidant for efficient cytoprotection to HK-2 cells.
Oligomeric Proanthocyanidins Ameliorate Cadmium-Induced Senescence of Osteocytes Through Combating Oxidative Stress and Inflammation.
Effects of ginger root extract on cognitive impairment and the Nrf2/GPX4/SLC7A11 signaling pathway in aluminum-exposed rats.
Downregulation of chemoresistance by claudin-14 silencing in human colorectal cancer cells.
ABCC1 deficiency potentiated noise-induced hearing loss in mice by impairing cochlear antioxidant capacity.
IFP35 aggravates Staphylococcus aureus infection by promoting Nrf2-regulated ferroptosis.
GOLPH3 inhibits erastin-induced ferroptosis in colorectal cancer cells.
Osthole exhibits the remedial potential for polycystic ovary syndrome mice through Nrf2-Foxo1-GSH-NF-κB pathway.
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling.
Mesenchymal Stromal Cell Therapy Alleviates Ovalbumin-Induced Chronic Airway Remodeling by Suppressing M2 Macrophage Polarization.
Glutamine Mitigates Oxidative Stress-Induced Matrix Degradation, Ferroptosis, and Pyroptosis in Nucleus Pulposus Cells via Deubiquitinating and Stabilizing Nrf2.
Ezetimibe ketone protects against renal ischemia-reperfusion injury and attenuates oxidative stress via activation of the Nrf2/HO-1 signaling pathway.
Crebanine mitigates glucocorticoid-induced osteonecrosis of the femoral head by restoring bone remodelling homeostasis via attenuating oxidative stress.
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
Hydroxygenkwanin exerts a neuroprotective effect by activating the Nrf2/ARE signaling pathway.
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Exosomes From Muscle-Derived Stem Cells Repair Peripheral Nerve Injury by Inhibiting Ferroptosis via the Keap1-Nrf2-Ho-1 Axis.
Herpotrichone A Exerts Neuroprotective Effects by Relieving Ferroptosis.
Brown adipose tissue-derived FGF21 mediates the cardioprotection of dexmedetomidine in myocardial ischemia/reperfusion injury.
Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT.
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.
Vaccarin suppresses diabetic nephropathy through inhibiting the EGFR/ERK1/2 signaling pathway.
Hsp90α promotes chemoresistance in pancreatic cancer by regulating Keap1-Nrf2 axis and inhibiting ferroptosis.
Mitigation of ROS-triggered endoplasmic reticulum stress by upregulating Nrf2 retards diabetic nephropathy.
Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy.
TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.
Inhaled aerosolized algal polysaccharides: A novel and reliable strategy for treating pneumonia through inflammation and oxidative stress inhibition.
Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2/HO-1 pathways.
Biochanin A: Disrupting the inflammatory vicious cycle for dry eye disease.
Construction of mitochondrial-targeting nano-prodrug for enhanced Rhein delivery and treatment for osteoarthritis in vitro.
Tricetin protects against liver fibrosis through promoting autophagy and Nrf2 signaling in hepatic stellate cells.
Nrf2 expression, mitochondrial fission, and neuronal apoptosis in the prefrontal cortex of methamphetamine abusers and rats.
Sofalcone attenuates neurodegeneration in MPTP-induced mouse model of Parkinson's disease by inhibiting oxidative stress and neuroinflammation.
Mesenchymal stem cell-derived extracellular vesicles mitigate neuronal damage from intracerebral hemorrhage by modulating ferroptosis.
Salvia miltiorrhiza suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling.
Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.
Redox Balance and Inflammatory Response in Follicular Fluids of Women Recovered by SARS-CoV-2 Infection or Anti-COVID-19 Vaccinated: A Combined Metabolomics and Biochemical Study.
Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells.
Amino acid deprivation induces TXNIP expression by NRF2 downregulation.
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.
Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages.
SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke.
Cichoric acid targets RANKL to inhibit osteoclastogenesis and prevent ovariectomy-induced bone loss.
CD44-targeted melanin-based nanoplatform for alleviation of ischemia/reperfusion-induced acute kidney injury.
Pseudolaric acid B exerts an antifungal effect and targets SIRT1 to ameliorate inflammation by regulating Nrf2/NF-κB pathways in fungal keratitis.
APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy.
SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress.
Therapeutic effect and mechanism of action of pterostilbene nano drugs in dry eye models.
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.
Glutathione Depletion-Induced Versatile Nanomedicine for Potentiating the Ferroptosis to Overcome Solid Tumor Radioresistance and Enhance Immunotherapy.
Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2/xCT/GPX4 signaling pathway.
Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction.
Very low-carbohydrate diet with higher protein ratio improves lipid metabolism and inflammation in rats with diet-induced nonalcoholic fatty liver disease.
Alginate oligosaccharide alleviates vascular aging by upregulating glutathione peroxidase 7.
A NRF2 Regulated and the Immunosuppressive Microenvironment Reversed Nanoplatform for Cholangiocarcinoma Photodynamic-Gas Therapy.
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Hesperidin ameliorates H(2)O(2)-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway.
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
A Flavonoid Glycoside Compound from Siraitia grosvenorii with Anti-Inflammatory and Hepatoprotective Effects In Vitro.
Guben Qingfei decoction attenuates LPS-induced acute lung injury by modulating the TLR4/NF-κB and Keap1/Nrf2 signaling pathways.
Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling.
NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury.
Neuroprotective effect of acetoxypachydiol against oxidative stress through activation of the Keap1-Nrf2/HO-1 pathway.
Differences in Airway Remodeling and Emphysematous Lesions between Rats Exposed to Smoke from New-Type and Conventional Tobacco Varieties.
Investigating the role of itaconate in macrophage activation and oxidative stress injury in sepsis-associated acute kidney injury.
The role of FPR2-mediated ferroptosis in formyl peptide-induced acute lung injury against endothelial barrier damage and protective effect of the mitochondria-derived peptide MOTS-c.
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53.
Dysregulated VEGF/VEGFR-2 Signaling and Plexogenic Lesions in the Embryonic Lungs of Chickens Predisposed to Pulmonary Arterial Hypertension.
Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression.
Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Wogonin Diminishes Radioresistance of Breast Cancer via Inhibition of the Nrf2/HIF-1[Formula: see text] Pathway.
Quercetin Ameliorates Diabetic Kidney Injury by Inhibiting Ferroptosis via Activating Nrf2/HO-1 Signaling Pathway.
Ethylhexadecyldimethylammonium bromide, a quaternary ammonium compound, controls inflammatory response through NRF2 pathway in a human immortalized keratinocyte cell line.
Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products.
N-acetyl cysteine inhibits IL-1α release from murine keratinocytes induced by 2-hydroxyethyl methacrylate.
Nrf2 Expression Is Decreased in LRRK2 Transgenic Mouse Brain and LRRK2 Overexpressing SH-SY5Y Cells.
Butylphthalide improves brain damage induced by renal ischemia-reperfusion injury rats through Nrf2/HO-1 and NOD2/MAPK/NF-κB pathways.
Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD).
Detection of Ferroptosis by Immunohistochemistry and Immunofluorescence.
OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.
Pterostilbene Confers Protection against Diquat-Induced Intestinal Damage with Potential Regulation of Redox Status and Ferroptosis in Broiler Chickens.
JFD, a Novel Natural Inhibitor of Keap1 Alkylation, Suppresses Intracellular Mycobacterium Tuberculosis Growth through Keap1/Nrf2/SOD2-Mediated ROS Accumulation.
Protective Effect of Alkaline Mineral Water on Calcium Oxalate-Induced Kidney Injury in Mice.
miR-432-5p Inhibits the Ferroptosis in Cardiomyocytes Induced by Hypoxia/Reoxygenation via Activating Nrf2/SLC7A11 Axis by Degrading Keap1.
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses.
Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK/ARE/Nrf2 pathway.
Probiotics attenuate valproate-induced liver steatosis and oxidative stress in mice.
Exploration of Artemisinin Against IgA Nephropathy via AKT/Nrf2 Pathway by Bioinformatics and Experimental Validation.
Mastoparan M Suppressed NLRP3 Inflammasome Activation by Inhibiting MAPK/NF-κB and Oxidative Stress in Gouty Arthritis.
Dental Pulp Stem Cells Ameliorate Elastase-Induced Pulmonary Emphysema by Regulating Inflammation and Oxidative Stress.
Shikimic acid (SA) inhibits neuro-inflammation and exerts neuroprotective effects in an LPS-induced in vitro and in vivo model.
Fecal microbiota transplantation from HUC-MSC-treated mice alleviates acute lung injury in mice through anti-inflammation and gut microbiota modulation.
Ursolic acid reduces oxidative stress injury to ameliorate experimental autoimmune myocarditis by activating Nrf2/HO-1 signaling pathway.
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway.
Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis.
Occlusion preconditioned mice are resilient to hypobaric hypoxia-induced myocarditis and arrhythmias due to enhanced immunomodulation, metabolic homeostasis, and antioxidants defense.
Ginsenoside ompound K reduces neuronal damage and improves neuronal synaptic dysfunction by targeting Aβ.
Resolvin D1/N-formyl peptide receptor 2 ameliorates paclitaxel-induced neuropathic pain through the activation of IL-10/Nrf2/HO-1 pathway in mice.
Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway.
Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal.
Pien-tze-huang promotes wound healing in streptozotocin-induced diabetes models associated with improving oxidative stress via the Nrf2/ARE pathway.
Phellodendronoside A Exerts Anticancer Effects Depending on Inducing Apoptosis Through ROS/Nrf2/Notch Pathway and Modulating Metabolite Profiles in Hepatocellular Carcinoma.
Inhibitory Effects of Esculetin on Liver Cancer Through Triggering NCOA4 Pathway-Mediation Ferritinophagy in vivo and in vitro.
Identification of cuproptosis-related biomarkers and analysis of immune infiltration in allograft lung ischemia-reperfusion injury.
Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway.
Methylglyoxal suppresses microglia inflammatory response through NRF2-IκBζ pathway.
Carnosine alleviates kidney tubular epithelial injury by targeting NRF2 mediated ferroptosis in diabetic nephropathy.
Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress.
Effect of renal denervation on cardiac remodelling and function in rats with chronic intermittent hypoxia.
TGF-β3 Protects Neurons Against Intermittent Hypoxia-Induced Oxidative Stress and Apoptosis Through Activation of the Nrf-2/KEAP1/HO-1 Pathway via Binding to TGF-βRI.
Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia.
Involvement of NADPH oxidases in the Na/K‑ATPase/Src/ROS oxidant amplification loop in renal fibrosis.
Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation.
Aloe-emodin alleviates doxorubicin-induced cardiotoxicity via inhibition of ferroptosis.
Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke.
Notopterol alleviates the progression of osteoarthritis: An in vitro and in vivo study.
Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis.
Cynarin alleviates intervertebral disc degeneration via protecting nucleus pulposus cells from ferroptosis.
Berberine protects cyclophosphamide and busulfan-induced premature ovarian insufficiency in mouse model.
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.
Pharmacological activation of the Nrf2 pathway by Taxifolin remodels articular cartilage microenvironment for the therapy of Osteoarthritis.
Liensinine pretreatment reduces inflammation, oxidative stress, apoptosis, and autophagy to alleviate sepsis acute kidney injury.
A Biomimetic Nanoparticle Exerting Protection against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS.
FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
Cell state transition analysis identifies interventions that improve control of Mycobacterium tuberculosis infection by susceptible macrophages.
Antidiabetic Effect of Collagen Peptides from Harpadon nehereus Bones in Streptozotocin-Induced Diabetes Mice by Regulating Oxidative Stress and Glucose Metabolism.
δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis.
Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression.
FGF2 Rescued Cisplatin-Injured Granulosa Cells through the NRF2-Autophagy Pathway.
Exploring anti-acute kidney injury mechanism of Dahuang-Gancao decoction by network pharmacology and experimental validation.
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis.
The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism.
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
Nuclear erythroid 2-related factor 2 protects against reactive oxygen species -induced preterm premature rupture of membranes through regulation of mitochondria†.
Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation.
Graphene oxide had adverse effects on sperm motility and morphology through oxidative stress.
Honokiol alleviates radiation-induced premature ovarian failure via enhancing Nrf2.
Perillaldehyde Mitigates Ionizing Radiation-Induced Intestinal Injury by Inhibiting Ferroptosis via the Nrf2 Signaling Pathway.
Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis.
Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia-reperfusion injury model of mice.
Anti-inflammatory activity of 2-methoxy-4-vinylphenol involves inhibition of lipopolysaccharide-induced inducible nitric oxidase synthase by heme oxygenase-1.
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway.
TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway.
NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11.
Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase.
SUMOylation of the ubiquitin ligase component KEAP1 at K39 upregulates NRF2 and its target function in lung cancer cell proliferation.
Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1/Nrf2 and inhibiting TLR4/NF-κB p65 pathways.
Effects of dietary resveratrol supplementation in cattle on the anti-oxidative capacity and meat quality of beef steaks under high‑oxygen packaging.
Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2/GPX4 pathway.
MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis.
Puerarin protects against acetaminophen-induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway.
Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke.
Citrus peel extract protects against diesel exhaust particle-induced chronic obstructive pulmonary disease-like lung lesions and oxidative stress.
Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis.
Paeoniflorin alleviates hypoxia/reoxygenation injury in HK-2 cells by inhibiting apoptosis and repressing oxidative damage via Keap1/Nrf2/HO-1 pathway.
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Potential regulatory role of the Nrf2/HMGB1/TLR4/NF-κB signaling pathway in lupus nephritis.
Conditional Dependency of LP-184 on Prostaglandin Reductase 1 is Synthetic Lethal in Pancreatic Cancers with DNA Damage Repair Deficiencies.
Eriocitrin inhibits epithelial-mesenchymal transformation (EMT) in lung adenocarcinoma cells via triggering ferroptosis.
Cyasterone ameliorates sepsis-related acute lung injury via AKT (Ser473)/GSK3β (Ser9)/Nrf2 pathway.
A Study of Gentianae Radix et Rhizoma Class Differences Based on Chemical Composition and Core Efficacy.
Verbascoside Elicits Its Beneficial Effects by Enhancing Mitochondrial Spare Respiratory Capacity and the Nrf2/HO-1 Mediated Antioxidant System in a Murine Skeletal Muscle Cell Line.
Partial Replacement of Diet with Dehulled Adlay Ameliorates Hepatic Steatosis, Inflammation, Oxidative Stress, and Gut Dysbiosis in Rats with Nonalcoholic Fatty Liver Disease.
High-sulfated derivative of polysaccharide from Ulva pertusa improves Adriamycin-induced nephrotic syndrome by suppressing oxidative stress.
Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca(2+) pathways.
Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia/reperfusion injury through PI3K/Akt-mediated Nrf2 signaling pathways.
Effective myocardial infarction treatment by targeted accumulation of Sulforaphane using porous magnetic silica nanoparticles.
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Polydopamine-loaded prunetin nanomaterials activate DRD2 to reduce UV-induced inflammation by stabilizing and promoting Nrf2 nuclear translocation.
Injectable microenvironment-responsive hydrogels with redox-activatable supramolecular prodrugs mediate ferroptosis-immunotherapy for postoperative tumor treatment.
The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress.
Network pharmacology and in vivo studies reveal the neuroprotective effects of paeoniflorin on Alzheimer's disease.
The novel β-TrCP protein isoform hidden in circular RNA confers trastuzumab resistance in HER2-positive breast cancer.
Mechanisms underlying citrinin-induced toxicity via oxidative stress and apoptosis-mediated by mitochondrial-dependent pathway in SH-SY5Y cells.
Orientin inhibits inflammation in chondrocytes and attenuates osteoarthritis through Nrf2/NF-κB and SIRT6/NF-κB pathway.
Propofol Pretreatment Inhibits Liver Damage in Mice with Hepatic Ischemia/Reperfusion Injury and Protects Human Hepatocyte in Hypoxia/Reoxygenation.
Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway.
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
BRD2 protects the rat H9C2 cardiomyocytes from hypoxia‑reoxygenation injury by targeting Nrf2/HO‑1 signaling pathway.
Fucoidan promotes angiogenesis and accelerates wound healing through AKT/Nrf2/HIF-1α signalling pathway.
The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury.
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway.
Engineering cannabidiol synergistic carbon monoxide nanocomplexes to enhance cancer therapy via excessive autophagy.
A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB pathway and activation Nrf2 pathway in macrophages.
BNTA attenuates temporomandibular joint osteoarthritis progression by directly targeting ALDH3A1: An in vivo and in vitro study.
Activation of Nrf2/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury.
Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy.
Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease.
High-fat stimulation induces atrial neural remodeling by reducing NO production via the CRIF1/eNOS/P21 axi.
Sulforaphane ameliorated podocyte injury according to regulation of the Nrf2/PINK1 pathway for mitophagy in diabetic kidney disease.
Compound 5 alleviated acute kidney injury without affecting the antitumor effect after cisplatin treatment.
Lactoferrin Alleviates Ethanol-Induced Injury via Promoting Nrf2 Nuclear Translocation in BRL-3A Rat Liver Cells.
Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation.
Ferrostatin-1 suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling.
Chlorogenic Acid Alleviated AFB1-Induced Hepatotoxicity by Regulating Mitochondrial Function, Activating Nrf2/HO-1, and Inhibiting Noncanonical NF-κB Signaling Pathway.
Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO-1 Pathway in BMSCs and Ovariectomized Mice.
IL-17A promotes tumorigenesis and upregulates PD-L1 expression in non-small cell lung cancer.
The protective effects of uric acid against myocardial ischemia via the Nrf2 pathway.
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Fucoxanthin alleviated myocardial ischemia and reperfusion injury through inhibition of ferroptosis via the NRF2 signaling pathway.
Identification of OLA1 as a Novel Protein Target of Vitexin to Ameliorate Dextran Sulfate Sodium-Induced Colitis with Tissue Thermal Proteome Profiling.
Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis.
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy.
MAGL inhibition relieves synovial inflammation and pain via regulating NOX4-Nrf2 redox balance in osteoarthritis.
Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36.
A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies.
Electrophilic reactive aldehydes as a therapeutic target in colorectal cancer prevention and treatment.
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Curcumin protects against doxorubicin induced oxidative stress by regulating the Keap1-Nrf2-ARE and autophagy signaling pathways.
Pgp3 protein of Chlamydia trachomatis inhibits apoptosis via HO-1 upregulation mediated by PI3K/Akt activation.
Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke.
Chrysin protects against cerebral ischemia-reperfusion injury in hippocampus via restraining oxidative stress and transition elements.
Epigallocatechin-3-gallate (EGCG) based metal-polyphenol nanoformulations alleviates chondrocytes inflammation by modulating synovial macrophages polarization.
C1q/tumor necrosis factor-related protein-9 exerts antioxidant and anti-inflammatory effects on oxygen-glucose deprivation/reoxygenation-stimulated neurons by modulating the Akt-GSK-3β-Nrf2 cascade via AdipoR1.
Aescin can alleviate NAFLD through Keap1-Nrf2 by activating antioxidant and autophagy.
Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice.
DNMT3A R882H mutation promotes acute leukemic cell survival by regulating glycolysis through the NRF2/NQO1 axis.
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination.
Red Ginseng Improves D-galactose-Induced Premature Ovarian Failure in Mice Based on Network Pharmacology.
Lactoferrin Relieves Deoxynivalenol-Induced Oxidative Stress and Inflammatory Response by Modulating the Nrf2/MAPK Pathways in the Liver.
Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway.
Protective effect and mechanism of Lycium ruthenicum polyphenols against acrylamide-induced neurotoxicity.
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1.
Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth.
PM(2.5) caused ferroptosis in spermatocyte via overloading iron and disrupting redox homeostasis.
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization.
Ripretinib induced skeletal muscle toxicity through mitochondrial impairment in C2C12 myotubes.
Sivelestat sodium attenuates acute lung injury by inhibiting JNK/NF-κB and activating Nrf2/HO-1 signaling pathways.
Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis.
The role of ferroptosis mediated by Bmal1/Nrf2 in nicotine -induce injury of BTB integrity.
Anti-inflammatory and antioxidative effects of gallic acid on experimental dry eye: in vitro and in vivo studies.
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
Oral administration of Lactobacillus plantarum JC7 alleviates OVA-induced murine food allergy through immunoregulation and restoring disordered intestinal microbiota.
Is Nrf2 Behind Endogenous Neuroprotection of the Hippocampal CA2-4,DG Region?
Andrographolide-treated bone marrow mesenchymal stem cells-derived conditioned medium protects cardiomyocytes from injury by metabolic remodeling.
Molecular alteration of the proteasome contributes to AD-like pathology in the brain of HFD-STZ diabetic rats.
Ro25-6981 alleviates neuronal damage and improves cognitive deficits by attenuating oxidative stress via the Nrf2/ARE pathway in ischemia/reperfusion rats.
Abamectin causes cardiac dysfunction in carp via inhibiting redox equilibrium and resulting in immune inflammatory response and programmed cell death.
Costunolide alleviates hyperglycaemia-induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress.
Protective effects of baicalin against L-glutamate-induced oxidative damage in HT-22 cells by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.
LncRNA UCA1 promoted cisplatin resistance in lung adenocarcinoma with HO1 targets NRF2/HO1 pathway.
Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss.
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib.
Uridine Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Ferroptosis of Macrophage.
Inhibition of p62 and/or NFE2L2 induced autophagy impaires esophageal squamous cell cancer metastasis by reversing EMT.
Antialcohol and Hepatoprotective Effects of Tamarind Shell Extract on Ethanol-Induced Damage to HepG2 Cells and Animal Models.
Apigenin improves cytotoxicity of antiretroviral drugs against HTLV-1 infected cells through the modulation of AhR signaling.
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
Photobiomodulation Controls Keratinocytes Inflammatory Response through Nrf2 and Reduces Langerhans Cells Activation.
Reduced SUMOylation of Nrf2 signaling contributes to its inhibition induced by amyloid-β.
Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery.
Effects and mechanisms of Xiaochaihu Tang against liver fibrosis: An integration of network pharmacology, molecular docking and experimental validation.
Tingli Dazao Decoction pretreatment ameliorates mitochondrial damage induced by oxidative stress in cardiomyocytes.
Buyang Huanwu decoction alleviates oxidative injury of cerebral ischemia-reperfusion through PKCε/Nrf2 signaling pathway.
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Polysaccharide from Flammulina velutipes residues protects mice from Pb poisoning by activating Akt/GSK3β/Nrf-2/HO-1 signaling pathway and modulating gut microbiota.
Ketogenic diets composed of long-chain and medium-chain fatty acids induce cardiac fibrosis in mice.
Farnesol Exerts Protective Effects against Chronic Sleep Deprivation-Induced Cognitive Impairment via Activation SIRT1/Nrf2 Pathway in the Hippocampi of Adult Mice.
UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis.
Tubastatin A potently inhibits GPX4 activity to potentiate cancer radiotherapy through boosting ferroptosis.
TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1.
Baicalin ameliorates high fat diet-induced nonalcoholic fatty liver disease in mice via adenosine monophosphate-activated protein kinase-mediated regulation of SREBP1/Nrf2/NF-κB signaling pathways.
Donor graft METTL3 gene transfer ameliorates rat liver transplantation ischemia-reperfusion injury by enhancing HO-1 expression in an m(6)A-dependent manner.
Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair.
Anti-Inflammatory Effects of New Naphthyridine from Sponge Aaptos suberitoides in LPS-Stimulated RAW 264.7 Macrophages via Regulation of MAPK and Nrf2 Signaling Pathways.
Schisandrin B Improves the Hypothermic Preservation of Celsior Solution in Human Umbilical Cord Mesenchymal Stem Cells.
Synergistic effects of combined treatment of 1,2-dichloroethane and high-dose ethanol on liver damage in mice and the related mechanisms.
Olanzapine-induced nonalcoholic fatty liver disease: The effects of differential food pattern and the involvement of PGRMC1 signaling.
Anti-oxidative-initiated cognitive impairment amelioration in Alzheimer's disease model rats through preventive transcutaneous electrical acupoint stimulation.
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling.
Wenqingyin suppresses ferroptosis in the pathogenesis of sepsis-induced liver injury by activating the Nrf2-mediated signaling pathway.
PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis.
Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure.
Ferulic Acid Alleviates Hepatic Lipid Accumulation and Inflammation by Improving Proximal and Distal Intestinal Barriers in NAFLD Mice.
A copper complex that combats triple negative breast cancer by restraining angiogenesis.
RETRACTED: Tangzhiqing-mediated NRF2 reduces autophagy-dependent ferroptosis to mitigate diabetes-related cognitive impairment neuronal damage.
Exercise reduces hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice via its effects against inflammation and oxidative stress.
Role of ionizing radiation activated NRF2 in lung cancer radioresistance.
Ebselen alleviates white matter lesions and improves cognitive deficits by attenuating oxidative stress via Keap1/Nrf2 pathway in chronic cerebral hypoperfusion mice.
Antioxidant Peptides from Monkfish Swim Bladders: Ameliorating NAFLD In Vitro by Suppressing Lipid Accumulation and Oxidative Stress via Regulating AMPK/Nrf2 Pathway.
Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke.
SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway.
Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression.
Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer.
CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade.
NFATc1-mediated expression of SLC7A11 drives sensitivity to TXNRD1 inhibitors in osteoclast precursors.
Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells.
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma.
Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders.
Liensinine, a alkaloid from lotus plumule, mitigates lipopolysaccharide-induced sepsis-associated encephalopathy through modulation of nuclear factor erythroid 2-related factor-mediated inflammatory biomarkers and mitochondria apoptosis.
Resveratrol Promotes Gluconeogenesis by Inhibiting SESN2-mTORC2-AKT Pathway in Calf Hepatocytes.
Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways.
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Glycyrrhizin protects against particulate matter-induced lung injury via regulation of endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis through Nrf2/HO-1/NQO1 signaling pathway.
Aloperine alleviates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome activation.
Denervation delays initial bone healing of rat tooth extraction socket.
Transcription Factor Nrf2 Modulates Lipopolysaccharide-Induced Injury in Bovine Endometrial Epithelial Cells.
Long noncoding RNA PSMA3-AS1 functions as a competing endogenous RNA to promote gastric cancer progression by regulating the miR-329-3p/ALDOA axis.
Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury.
Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice.
Ammonium tetrathiomolybdate relieves oxidative stress in cisplatin-induced acute kidney injury via NRF2 signaling pathway.
Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways.
Baicalin induces ferroptosis in osteosarcomas through a novel Nrf2/xCT/GPX4 regulatory axis.
The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing.
Neuroprotective effect of a medium-chain triglyceride ketogenic diet on MPTP-induced Parkinson's disease mice: a combination of transcriptomics and metabolomics in the substantia nigra and fecal microbiome.
Protective effect of total flavonoids of Engelhardia roxburghiana Wall. leaves against radiation-induced intestinal injury in mice and its mechanism.
Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro.
Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1.
Tripterygium glycosides reverse chemotherapy resistance in ovarian cancer by targeting the NRF2/GPX4 signal axis to induce ferroptosis of drug-resistant human epithelial ovarian cancer cells.
Gomphrena globosa L. extract alleviates carbon tetrachoride-induced liver injury in mice by activating antioxidant signaling pathways and promoting autophagy.
Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway.
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Diterpenoids with anti-inflammatory activity from Euphorbia wallichii.
A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis.
TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K/Akt/Nrf2/Ferritin H pathway.
Pine pollen extract alleviates ethanol-induced oxidative stress and apoptosis in HepG2 cells via MAPK signaling.
Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.
Pterostilbene alleviated NAFLD via AMPK/mTOR signaling pathways and autophagy by promoting Nrf2.
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
Nrf2 attenuates methamphetamine-induced myocardial injury by regulating oxidative stress and apoptosis in mice.
Effects of NBP on postoperative cognitive dysfunction in rats via Nrf 2/ARE pathway.
Therapeutic Hypothermia after Cardiac Arrest Attenuates Hindlimb Paralysis and Damage of Spinal Motor Neurons and Astrocytes through Modulating Nrf2/HO-1 Signaling Pathway in Rats.
Bifidobacterium animalis A12 and Lactobacillus salivarius M18-6 Alleviate Alcohol Injury by keap1-Nrf2 Pathway and Thioredoxin System.
Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway.
Evaluation of toxicological effects of bisphenol S with an in vitro human bone marrow mesenchymal stem cell: Implications for bone health.
CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
Fresh Medium or L-Cystine as an Effective Nrf2 Inducer for Cytoprotection in Cell Culture.
Drug repurposing of ilepcimide that ameliorates experimental autoimmune encephalomyelitis via restricting inflammatory response and oxidative stress.
Hydrogen sulfide protects retinal pigment epithelium cells against ferroptosis through the AMPK- and p62-dependent non-canonical NRF2-KEAP1 pathway.
Organic extracts in PM2.5 are the major triggers to induce ferroptosis in SH-SY5Y cells.
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
Melatonin Alleviates the Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway.
Dual Antioxidant DH-217 Mitigated Cerebral Ischemia-Reperfusion Injury by Targeting IKKβ/Nrf2/HO-1 Signal Axis.
Corynoline ameliorates dextran sulfate sodium-induced colitis in mice by modulating Nrf2/NF-κB pathway.
Curcumin alleviates ketamine-induced oxidative stress and apoptosis via Nrf2 signaling pathway in rats' cerebral cortex and hippocampus.
TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy.
Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors.
Dietary curcumin supplementation relieves hydrogen peroxide-induced testicular injury by antioxidant and anti-apoptotic effects in roosters.
Protective effect of human umbilical cord mesenchymal stem cell derived conditioned medium in a mutant TDP-43 induced motoneuron-like cellular model of ALS.
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Chemical constituents from the stems and leaves of Amomum villosum Lour. and their anti-inflammatory and antioxidant activities.
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis.
Cold exposure induces browning of bovine subcutaneous white fat in vivo and in vitro.
Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly.
Active Nrf2 signaling flexibly regulates HO-1 and NQO-1 in hypoxic Gansu Zokor (Eospalax cansus).
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways.
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
Secretome of hESC-Derived MSC-like Immune and Matrix Regulatory Cells Mitigate Pulmonary Fibrosis through Antioxidant and Anti-Inflammatory Effects.
NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress.
Cytotoxic and Antioxidant Activity of Hypericum perforatum L. Extracts against Human Melanoma Cells from Different Stages of Cancer Progression, Cultured under Normoxia and Hypoxia.
Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis.
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke.
Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation.
Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy.
Elabela-APJ axis attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal ferroptosis.
Ferroptosis Inducers Kill Mesenchymal Stem Cells Affected by Neuroblastoma.
Nanodrug rescues liver fibrosis via synergistic therapy with H(2)O(2) depletion and Saikosaponin b1 sustained release.
Piperlongumine conjugates induce targeted protein degradation.
RTA dh404 Induces Cell Cycle Arrest, Apoptosis, and Autophagy in Glioblastoma Cells.
Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3/ATF3/SLC7A11 signaling.
β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells.
Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis.
Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages.
Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK/NRF2 pathway.
Anesthetic propofol inhibits ferroptosis and aggravates distant cancer metastasis via Nrf2 upregulation.
17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation.
Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway.
Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway.
Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress.
Sulforaphane attenuates irradiation induced testis injury in mice.
Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway.
Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats.
Park7 protects retinal ganglion cells and promotes functional preservation after optic nerve crush via regulation of the Nrf2 signaling pathway.
Torachrysone-8-O-β-d-glucoside mediates anti-inflammatory effects by blocking aldose reductase-catalyzed metabolism of lipid peroxidation products.
Tussilagone inhibits osteoclastogenesis by modulating mitochondrial function and ROS production involved Nrf2 activation.
Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2.
ZnO nanoparticles impair autophagic flux and cell viability through the TRIM16-NRF2-p62 pathway in inflammatory keratinocytes.
Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signalling.
Upregulation of autotaxin by oxidative stress via Nrf2 activation: A novel insight into the compensation mechanism in preeclamptic placenta.
Eicosapentaenoic acid enhances the sensitivity of osteosarcoma to cisplatin by inducing ferroptosis through the DNA-PKcs/AKT/NRF2 pathway and reducing PD-L1 expression to attenuate immune evasion.
Umbelliferone attenuates cisplatin-induced acute kidney injury by inhibiting oxidative stress and inflammation via NRF2.
Hyperacute autonomic and cortical function recovery following cardiac arrest resuscitation in a rodent model.
Oat Peptides Alleviate Dextran Sulfate Sodium Salt-Induced Colitis by Maintaining the Intestinal Barrier and Modulating the Keap1-Nrf2 Axis.
The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.
Klotho activation of Nrf2 inhibits the ferroptosis signaling pathway to ameliorate sepsis-associated acute kidney injury.
Dietary pyrroloquinoline quinone improvement of the antioxidant capacity of laying hens and eggs are linked to the alteration of Nrf2/HO-1 pathway and gut microbiota.
Novel Antioxidant Peptides Derived from Feather Keratin Alleviate H(2)O(2)-Induced Oxidative Damage in HepG2 Cells via Keap1/Nrf2 Pathway.
DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways.
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
Development of KEAP1-targeting PROTAC and its antioxidant properties: In vitro and in vivo.
CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma.
Inhibition of SIRT1 promotes ultraviolet B induced cataract via downregulation of the KEAP1/NFE2L2 signaling pathway.
miR-1273h-5p protects the human corneal epithelium against UVR-induced oxidative stress and apoptosis: Role of miR-1273h-5p in climatic droplet keratopathy.
ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1(G93A) mutation and exerts neuroprotection in amyotrophic lateral sclerosis.
Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Oxazole-4-carboxamide/butylated hydroxytoluene hybrids with GSK-3β inhibitory and neuroprotective activities against Alzheimer's disease.
High-Frequency Repetitive Magnetic Stimulation Activates Bactericidal Activity of Macrophages via Modulation of p62/Keap1/Nrf2 and p38 MAPK Pathways.
Metabolomic Analysis of Trehalose Alleviating Oxidative Stress in Myoblasts.
Sarmentosin Induces Autophagy-dependent Apoptosis via Activation of Nrf2 in Hepatocellular Carcinoma.
FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner.
Liquiritigenin Confers Liver Protection by Enhancing NRF2 Signaling through Both Canonical and Non-canonical Signaling Pathways.
Effects of Different Dietary Zinc (Zn) Sources on Growth Performance, Zn Metabolism, and Intestinal Health of Grass Carp.
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
Retinoic acid protects against lipopolysaccharide-induced ferroptotic liver injury and iron disorders by regulating Nrf2/HO-1 and RARβ signaling.
B7-H3 confers stemness characteristics to gastric cancer cells by promoting glutathione metabolism through AKT/pAKT/Nrf2 pathway.
Neuroprotective Effects of Activin A against Cerebral Ischemia/Reperfusion Injury in Mice by Enhancing Nrf2 Expression to Attenuate Neuronal Ferroptosis.
The mitochondrial-derived peptide MOTS-c suppresses ferroptosis and alleviates acute lung injury induced by myocardial ischemia reperfusion via PPARγ signaling pathway.
linc01515 regulates PM(2.5)-induced oxidative stress via targeting NRF2 in airway epithelial cells.
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity.
Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota.
Exosomes secreted by mesenchymal stem cells delay brain aging by upregulating SIRT1 expression.
Correction: Tang et al. Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop. Nutrients 2022, 14, 1504.
TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling.
Nrf2 protects against methamphetamine-induced nephrotoxicity by mitigating oxidative stress and autophagy in mice.
Ginsenoside Rg1 protects cardiac mitochondrial function via targeting GSTP1 to block S-glutathionylation of optic atrophy 1.
Cold atmospheric plasma alleviates radiation-induced skin injury by suppressing inflammation and promoting repair.
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis.
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
Pterostilbene ameliorates oxidative damage and ferroptosis in human ovarian granulosa cells by regulating the Nrf2/HO-1 pathway.
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Ginsenoside Rd promotes omentin secretion in adipose through TBK1-AMPK to improve mitochondrial biogenesis via WNT5A/Ca(2+) pathways in heart failure.
Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent manner.
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice.
Ampicillin exacerbates acetaminophen-induced acute liver injury by inducing intestinal microbiota imbalance and butyrate reduction.
Dimethyl fumarate protects against hepatic ischemia-reperfusion injury by alleviating ferroptosis via the NRF2/SLC7A11/HO-1 axis.
Ameliorative effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 signaling pathway.
Isosinensetin alleviates estrogen deficiency-induced osteoporosis via suppressing ROS-mediated NF-κB/MAPK signaling pathways.
Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs.
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion.
Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-κB pathways.
A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns.
Synthesis of Lathyrol PROTACs and Evaluation of Their Anti-Inflammatory Activities.
Continuous Monochromatic Blue Light Exacerbates High-Fat Diet-Induced Kidney Injury via Corticosterone-Mediated Oxidative Stress.
Iron Saturation Drives Lactoferrin Effects on Oxidative Stress and Neurotoxicity Induced by HIV-1 Tat.
Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling.
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2.
Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species.
Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway.
Variable p53/Nrf2 crosstalk contributes to triptolide-induced hepatotoxic process.
Involvements of Nrf2 and oxidative stress in the ozone-elicited exacerbation in an allergic rhinitis model.
Polysaccharides extracted from mulberry fruits (Morus nigra L.): antioxidant effect of ameliorating H(2)O(2)-induced liver injury in HepG2 cells.
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
Blue LED light induces cytotoxicity via ROS production and mitochondrial damage in bovine subcutaneous preadipocytes.
Traditional Chinese medicine prescriptions (XJZ, JSS) ameliorate spleen inflammatory response and antioxidant capacity by synergistically regulating NF-κB and Nrf2 signaling pathways in piglets.
Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats.
Adaptive mechanisms in no flow vs. low flow ischemia in equine jejunum epithelium: Different paths to the same destination.
The beneficial effects of traditional Chinese medicine on antioxidative status and inflammatory cytokines expression in the liver of piglets.
Rutin Supplementation Reduces Oxidative Stress, Inflammation and Apoptosis of Mammary Gland in Sheep During the Transition Period.
The Protective Effect of Sulforaphane on Dextran Sulfate Sodium-Induced Colitis Depends on Gut Microbial and Nrf2-Related Mechanism.
Trans-anethole Ameliorates Intestinal Injury Through Activation of Nrf2 Signaling Pathway in Subclinical Necrotic Enteritis-Induced Broilers.
Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress.
Using Collagen Peptides From the Skin of Monkfish (Lophius litulon) to Ameliorate Kidney Damage in High-Fat Diet Fed Mice by Regulating the Nrf2 Pathway and NLRP3 Signaling.
Effects of folic acid on oxidative damage of kidney in lead-exposed rats.
Tannic acid attenuates intestinal oxidative damage by improving antioxidant capacity and intestinal barrier in weaned piglets and IPEC-J2 cells.
Tanshinone IIA Regulates Keap1/Nrf2 Signal Pathway by Activating Sestrin2 to Restrain Pulmonary Fibrosis.
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance.
Corrigendum to "Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway".
Fibroblast Growth Factor 19 Improves LPS-Induced Lipid Disorder and Organ Injury by Regulating Metabolomic Characteristics in Mice.
Carbon Monoxide-Releasing Molecule-3 Suppresses the Malignant Biological Behavior of Tongue Squamous Cell Carcinoma via Regulating Keap1/Nrf2/HO-1 Signaling Pathway.
Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway.
NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules.
Exosomes Derived from Baicalin-Pretreated Mesenchymal Stem Cells Alleviate Hepatocyte Ferroptosis after Acute Liver Injury via the Keap1-NRF2 Pathway.
Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R(-)/(-)) Mice.
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Metabolism-Related Gene TXNRD1 Regulates Inflammation and Oxidative Stress Induced by Cigarette Smoke through the Nrf2/HO-1 Pathway in the Small Airway Epithelium.
Paeoniflorin Regulates NEDD4L/STAT3 Pathway to Induce Ferroptosis in Human Glioma Cells.
Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway.
Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity.
Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin-Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway.
Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue.
Tripeptide Leu-Pro-Phe from Corn Protein Hydrolysates Attenuates Hyperglycemia-Induced Neural Tube Defect in Chicken Embryos.
Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis.
Homeobox A1 Facilitates Immune Escape and Alleviates Oxidative Stress in Lung Adenocarcinoma.
Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2'-Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester.
HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation.
Theaflavin-3,3'-Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis.
Theaflavin-3,3'-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways.
Streptococcus lutetiensis Induces Autophagy via Oxidative Stress in Bovine Mammary Epithelial Cells.
Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice.
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
TRPV1 Modulator Ameliorates Alzheimer-Like Amyloid-β Neuropathology via Akt/Gsk3β-Mediated Nrf2 Activation in the Neuro-2a/APP Cell Model.
Ginsenoside Rg1 Reduces Oxidative Stress Via Nrf2 Activation to Regulate Age-Related Mesenchymal Stem Cells Fate Switch Between Osteoblasts and Adipocytes.
Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury.
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway.
Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane.
Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model.
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.
Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress.
Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.
Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.
Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer's disease.
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Caryophyllene Oxide Induces Ferritinophagy by Regulating the NCOA4/FTH1/LC3 Pathway in Hepatocellular Carcinoma.
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs.
Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation.
Naringin Relieves Diabetic Cardiac Autonomic Neuropathy Mediated by P2Y(14) Receptor in Superior Cervical Ganglion.
Kaempferol From Penthorum chinense Pursh Attenuates Hepatic Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Inflammation Through Activation of the Nrf2/HO-1 Signaling Pathway.
Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling.
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1.
Sleeve Gastrectomy-Induced AMPK Activation Attenuates Diabetic Cardiomyopathy by Maintaining Mitochondrial Homeostasis via NR4A1 Suppression in Rats.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Nrf2 Signaling Pathway Mediates the Protective Effects of Daphnetin Against D-Galactose Induced-Premature Ovarian Failure.
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.
Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway.
Yinchen Linggui Zhugan decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease by modulation of SIRT1/Nrf2 signaling pathway and gut microbiota.
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
WASH regulates the oxidative stress Nrf2/ARE pathway to inhibit proliferation and promote apoptosis of HeLa cells under the action of Jolkinolide B.
Theaflavin Attenuates TBHP-Induced Endothelial Cells Oxidative Stress by Activating PI3K/AKT/Nrf2 and Accelerates Wound Healing in Rats.
Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.
Cytoglobin inhibits non-thermal plasma-induced apoptosis in melanoma cells through regulation of the NRF2-mediated antioxidant response.
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection.
Colchicine improves severe acute pancreatitis-induced acute lung injury by suppressing inflammation, apoptosis and oxidative stress in rats.
Chaihujialonggumulitang shows psycho-cardiology therapeutic effect on acute myocardial infarction with comorbid anxiety by the activation of Nrf2/HO-1 pathway and suppression of oxidative stress and apoptosis.
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
1,3-Dichloro-2-propanol-Induced Renal Tubular Cell Necroptosis through the ROS/RIPK3/MLKL Pathway.
Hawk Tea Flavonoids as Natural Hepatoprotective Agents Alleviate Acute Liver Damage by Reshaping the Intestinal Microbiota and Modulating the Nrf2 and NF-κB Signaling Pathways.
Omarigliptin Mitigates 6-Hydroxydopamine- or Rotenone-Induced Oxidative Toxicity in PC12 Cells by Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Actions.
IDH1 Promotes Foam Cell Formation by Aggravating Macrophage Ferroptosis.
Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway.
Fucoxanthin ameliorated myocardial fibrosis in STZ-induced diabetic rats and cell hypertrophy in HG-induced H9c2 cells by alleviating oxidative stress and restoring mitophagy.
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling.
Glucose Increases Hepatic Mitochondrial Antioxidant Enzyme Activities in Insulin Resistant Rats Following Chronic Angiotensin Receptor Blockade.
A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells.
Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.
Carbon tetrachloride exposure induces ovarian damage through oxidative stress and inflammatory mediated ovarian fibrosis.
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway.
Quercetin in Tonglong Qibi decoction ameliorates testosterone-induced benign prostatic hyperplasia in rats by regulating Nrf2 signalling pathways and oxidative stress.
Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects.
Antihepatofibrotic effect of Guizhifuling pill on carbon tetrachloride-induced liver fibrosis in mice.
CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway.
Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO-1 signaling pathway in mice.
Effects of Inorganic and Organic Manganese Supplementation on Growth Performance, Tibia Development, and Oxidative Stress in Broiler Chickens.
Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling.
LipoxinA(4) analog BML-111 protects podocytes cultured in high-glucose medium against oxidative injury via activating Nrf2 pathway.
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury.
Immature rat testis sustained long-term development using an integrative model.
DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway.
Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease.
Potential contribution of early endothelial progenitor cell (eEPC)-to-macrophage switching in the development of pulmonary plexogenic lesion.
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise.
Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems.
PLK-1 Interacting Checkpoint Helicase, PICH, Mediates Cellular Oxidative Stress Response.
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages.
Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy.
AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway.
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Accelerated Bone Regeneration by an Astaxanthin-Modified Antioxidant Aerogel through Relieving Oxidative Stress via the NRF2 Signaling Pathway.
Photoprotective Effects of Cannabidiol against Ultraviolet-B-Induced DNA Damage and Autophagy in Human Keratinocyte Cells and Mouse Skin Tissue.
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis.
Betaine Ameliorates Acute Sever Ulcerative Colitis by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis.
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.
Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Realgar-induced nephrotoxicity via ferroptosis in mice.
OL-FS13 alleviates experimental cerebral ischemia-reperfusion injury.
Protective role of TLR9-induced macrophage/microglia phagocytosis after experimental intracerebral hemorrhage in mice.
Xiaojianzhong decoction attenuates gastric mucosal injury by activating the p62/Keap1/Nrf2 signaling pathway to inhibit ferroptosis.
Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H(2)O(2)-induced BV-2 microglial cells injury.
Magnesium isoglycyrrhizinate ameliorates lipopolysaccharide-induced liver injury by upregulating autophagy and inhibiting inflammation via IL-22 expression.
Spatial Analysis of NQO1 in Non-Small Cell Lung Cancer Shows Its Expression Is Independent of NRF1 and NRF2 in the Tumor Microenvironment.
5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages.
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.
Neutrophil Nanovesicle Protects against Experimental Autoimmune Encephalomyelitis through Enhancing Myelin Clearance by Microglia.
Oxidative stress in the RVLM mediates sympathetic hyperactivity induced by circadian disruption.
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7.
BP5 alleviates endotoxemia-induced acute lung injury by activating Nrf2 via dual regulation of the Keap1-Nrf2 interaction and the Akt (Ser473)/GSK3β (Ser9)/Fyn pathway.
pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance "One Stone Four Birds" Effect of Rhein on Ulcerative Colitis.
Tea Tree Oil Mediates Antioxidant Factors Relish and Nrf2-Autophagy Axis Regulating the Lipid Metabolism of Macrobrachium rosenbergii.
Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling.
Salecan ameliorates liver injury by regulating gut microbiota and its metabolites.
Antioxidant Effects of Roasted Licorice in a Zebrafish Model and Its Mechanisms.
Silibinin improves L-cell mass and function through an estrogen receptor-mediated antioxidative mechanism.
LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1.
Collagen peptides from Acaudina molpadioides prevent CCl(4) -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.
MCFA alleviate H(2) O(2) -induced oxidative stress in AML12 cells via the ERK1/2/Nrf2 pathway.
Protective effect of rutin against diabetes-associated cognitive decline in rats.
Manganese Mitigates Heat Stress-Induced Apoptosis by Alleviating Endoplasmic Reticulum Stress and Activating the NRF2/SOD2 Pathway in Primary Chick Embryonic Myocardial Cells.
Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2.
Rhein regulates redox-mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage-activated crosstalk.
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6.
Novel 18β-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity.
Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury.
Nrf2 Transcriptional Activity Governs Intestine Development.
A transcriptomics and molecular biology based investigation reveals the protective effect and mechanism of carnosol on t-BHP induced HRMECs via Nrf2 signaling pathway.
Nrf2 and NF-κB/NLRP3 inflammasome pathways are involved in Prototheca bovis infections of mouse mammary gland tissue and mammary epithelial cells.
Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPARγ pathways in H9c2 cardiomyocytes.
Photothermal therapy with regulated Nrf2/NF-κB signaling pathway for treating bacteria-induced periodontitis.
Identification of inflammatory response and alternative splicing in acute kidney injury and experimental verification of the involvement of RNA‑binding protein RBFOX1 in this disease.
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Protective effect of resveratrol against hydrogen peroxide-induced oxidative stress in bovine skeletal muscle cells.
Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling.
Klotho alleviates NLRP3 inflammasome-mediated neuroinflammation in a temporal lobe epilepsy rat model by activating the Nrf2 signaling pathway.
Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway.
DHA-Enriched Phospholipids and EPA-Enriched Phospholipids Alleviate Lipopolysaccharide-Induced Intestinal Barrier Injury in Mice via a Sirtuin 1-Dependent Mechanism.
Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells.
Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents.
Novel Prenylated Indole Alkaloids with Neuroprotection on SH-SY5Y Cells against Oxidative Stress Targeting Keap1-Nrf2.
Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration.
Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway.
Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome.
Obstructive Sleep Apnea Affects Lacrimal Gland Function.
Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses.
Hepatic Lipid Accumulation and Dysregulation Associate with Enhanced Reactive Oxygen Species and Pro-Inflammatory Cytokine in Low-Birth-Weight Goats.
Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.
Potential for reversing miR-634-mediated cytoprotective processes to improve efficacy of chemotherapy against oral squamous cell carcinoma.
The Inflammatory Response in Human Keratinocytes Exposed to Cinnamaldehyde Is Regulated by Nrf2.
Centrosomal protein 290 is a novel prognostic indicator that modulates liver cancer cell ferroptosis via the Nrf2 pathway.
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment.
Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.
HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma.
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation in vitro.
Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative response.
Antagonistic effects of selenium on lead-induced oxidative stress and apoptosis of Leydig cells in sheep.
m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.
Bioinspired Multifunctional Black Phosphorus Hydrogel with Antibacterial and Antioxidant Properties: A Stepwise Countermeasure for Diabetic Skin Wound Healing.
6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-κB pathway in H9c2 cells.
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice.
Protective Effect of Lycium ruthenicum Polyphenols on Oxidative Stress against Acrylamide Induced Liver Injury in Rats.
Novel Probiotic Lactic Acid Bacteria Were Identified from Healthy Infant Feces and Exhibited Anti-Inflammatory Capacities.
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function.
Constant light in early life induces fear-related behavior in chickens with suppressed melatonin secretion and disrupted hippocampal expression of clock- and BDNF-associated genes.
Mesenchymal stem cells improve redox homeostasis and mitochondrial respiration in fibroblast cell lines with pathogenic MT-ND3 and MT-ND6 variants.
Inhibition of Nicotinamide adenine dinucleotide phosphate oxidase 4 attenuates cell apoptosis and oxidative stress in a rat model of polycystic ovary syndrome through the activation of Nrf-2/HO-1 signaling pathway.
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and ferroptosis in male reproduction of mice and TM4 Sertoli cells exposed to PM(2.5).
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles.
Antioxidant potential of Pediococcus pentosaceus strains from the sow milk bacterial collection in weaned piglets.
Structure of the nutrient-sensing hub GATOR2.
Fibroblast growth factor 9 attenuates sepsis-induced fulminant hepatitis in mice.
CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy.
GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma.
2-undecanone protects against fine particles-induced heart inflammation via modulating Nrf2/HO-1 and NF-κB pathways.
Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway.
Enhanced Extracellular Matrix Degradation in Growth Plate Contributes to Manganese Deficiency-Induced Tibial Dyschondroplasia in Broiler Chicks.
The neuroprotective effects of paeoniflorin against MPP(+)-induced damage to dopaminergic neurons via the Akt/Nrf2/GPX4 pathway.
Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.
Maackiain protects against sepsis via activating AMPK/Nrf2/HO-1 pathway.
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
The Protective Effects of Apigenin Against Radiation-Induced Intestinal Injury.
Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway.
Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway.
Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ(1-42)-induced Alzheimer's disease mice and glutamate-injured HT22 cells.
Lactoferrin Prevents Chronic Alcoholic Injury by Regulating Redox Balance and Lipid Metabolism in Female C57BL/6J Mice.
Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway.
T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells.
Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats.
Antioxidant Effects of DPP-4 Inhibitors in Early Stages of Experimental Diabetic Retinopathy.
Bisdemethoxycurcumin Attenuated Renal Injury via Activation of Keap1/Nrf2 Pathway in High-Fat Diet-Fed Mice.
Oxidative injury induced by drinking water disinfection by-products dibromoacetonitrile and dichloroacetonitrile in mouse hippocampal neuronal cells: The protective effect of N-acetyl-L-cysteine.
Salvianolate ameliorates renal tubular injury through the Keap1/Nrf2/ARE pathway in mouse kidney ischemia-reperfusion injury.
Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca(2+) release from the ER.
An auto-photoacoustic melanin-based drug delivery nano-platform for self-monitoring of acute kidney injury therapy via a triple-collaborative strategy.
Procyanidin B2 Alleviates Heat-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.
GSTM3 deficiency impedes DNA mismatch repair to promote gastric tumorigenesis via CAND1/NRF2-KEAP1 signaling.
Angiotensin (1-7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats.
Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.
Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway.
Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice.
GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder.
Role of Nox4 in High Calcium-Induced Renal Oxidative Stress Damage and Crystal Deposition.
Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response.
Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.
Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice.
CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway.
Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner.
Genistein mitigates oxidative stress and inflammation by regulating Nrf2/HO-1 and NF-κB signaling pathways in hypoxic-ischemic brain damage in neonatal mice.
Curcumin reduces oxidative stress and fat deposition in longissimus dorsi muscle of intrauterine growth-retarded finishing pigs.
Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway.
Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats.
Endothelial cell metabolic memory causes cardiovascular dysfunction in diabetes.
Betulinic acid-nucleoside hybrid prevents acute alcohol -induced liver damage by promoting anti-oxidative stress and autophagy.
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.
Hyperglycemia Induces Meibomian Gland Dysfunction.
Glyphosate-induced gut microbiota dysbiosis facilitates male reproductive toxicity in rats.
Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects.
Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo.
NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Liraglutide Regulates Mitochondrial Quality Control System Through PGC-1α in a Mouse Model of Parkinson's Disease.
Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model.
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance.
Dietary mulberry-leaf flavonoids improve the eggshell quality of aged breeder hens.
Emodin ameliorates antioxidant capacity and exerts neuroprotective effect via PKM2-mediated Nrf2 transactivation.
Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway.
Pharmacological Effects of Gami-Yukmijihwang-Tang on the Lipopolysaccharide-Induced Hippocampus Oxidation and Inflammation via Regulation of Sirt6.
Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway.
The dual role of p62 in ferroptosis of glioblastoma according to p53 status.
18β-Glycyrrhetinic acid suppresses allergic airway inflammation through NF-κB and Nrf2/HO-1 signaling pathways in asthma mice.
Hydroxytyrosol Alleviates Dextran Sulfate Sodium-Induced Colitis by Modulating Inflammatory Responses, Intestinal Barrier, and Microbiome.
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway.
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
Mitochondria-Dependent Oxidative Stress Mediates ZnO Nanoparticle (ZnO NP)-Induced Mitophagy and Lipotoxicity in Freshwater Teleost Fish.
Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities.
Anti-fatigue effect of hypericin in a chronic forced exercise mouse model.
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Basic fibroblast growth factor protects against liver ischemia-reperfusion injury via the Nrf2/Hippo signaling pathway.
Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway.
A plant-derived natural photosynthetic system for improving cell anabolism.
ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
Bone marrow-derived mesenchymal stem cells ameliorate severe acute pancreatitis by inhibiting oxidative stress in rats.
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.
Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice.
Antidiabetic drug metformin suppresses tumorigenesis through inhibition of mevalonate pathway enzyme HMGCS1.
Ferroptosis contributes to hypoxic-ischemic brain injury in neonatal rats: Role of the SIRT1/Nrf2/GPx4 signaling pathway.
Nickel nanoparticles exert cytotoxic effects on trophoblast HTR-8/SVneo cells possibly via Nrf2/MAPK/caspase 3 pathway.
Spermidine Alleviates Intrauterine Hypoxia-Induced Offspring Newborn Myocardial Mitochondrial Damage in Rats by Inhibiting Oxidative Stress and Regulating Mitochondrial Quality Control.
Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing.
Defective autophagy triggered by arterial cyclic stretch promotes neointimal hyperplasia in vein grafts via the p62/nrf2/slc7a11 signaling pathway.
Epoxymicheliolide prevents dextran sulfate sodium-induced colitis in mice by inhibiting TAK1-NF-κB pathway and activating Keap1-NRF2 signaling in macrophages.
Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway.
Cycloastragenol suppresses M1 and promotes M2 polarization in LPS-stimulated BV-2 cells and ischemic stroke mice.
Mefunidone ameliorates lipopolysaccharide-induced acute lung injury through inhibiting MAPK signaling pathway and enhancing Nrf2 pathway.
Gankyrin and TIGAR cooperatively accelerate glucose metabolism toward the PPP and TCA cycle in hepatocellular carcinoma.
Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.
Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury.
Probiotic-fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota.
Sulforaphane Ameliorates Hepatic Lipid Metabolism via Modulating Lipophagy In Vivo and In Vitro.
Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke.
Dehydroeburicoic Acid, a Dual Inhibitor against Oxidative Stress in Alcoholic Liver Disease.
Trehalose prevents glyphosate-induced testicular damage in roosters via its antioxidative properties.
Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo.
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence.
G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes.
Autophagy inhibition and reactive oxygen species elimination by acetyl-CoA acetyltransferase 1 through fused in sarcoma protein to promote prostate cancer.
Improvement in heat stress-induced multiple organ dysfunction and intestinal damage through protection of intestinal goblet cells from prostaglandin E1 analogue misoprostol.
Puerarin alleviates cadmium-induced rat neurocyte injury by alleviating Nrf2-mediated oxidative stress and inhibiting mitochondrial unfolded protein response.
The Nrf2 inhibitor brusatol synergistically enhances the cytotoxic effect of lapatinib in HER2-positive cancers.
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway.
TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway.
The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1.
MgIG exerts therapeutic effects on crizotinib-induced hepatotoxicity by limiting ROS-mediated autophagy and pyroptosis.
Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol-Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways.
Nrf2 Activation and NF-Kb & caspase/bax signaling inhibition by sodium butyrate alleviates LPS-induced cell injury in bovine mammary epithelial cells.
Activation of AMPK/p38/Nrf2 is involved in resveratrol alleviating myocardial ischemia-reperfusion injury in diabetic rats as an endogenous antioxidant stress feedback.
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration.
Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes.
LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination.
Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells.
Design of Diselenide-Bridged Hyaluronic Acid Nano-antioxidant for Efficient ROS Scavenging to Relieve Colitis.
Aucubin promotes bone-fracture healing via the dual effects of anti-oxidative damage and enhancing osteoblastogenesis of hBM-MSCs.
Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis.
Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector.
ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression.
Cytoglobin Silencing Promotes Melanoma Malignancy but Sensitizes for Ferroptosis and Pyroptosis Therapy Response.
Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.
4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury.
Fermented noni (Morinda citrifolia L.) fruit juice improved oxidative stress and insulin resistance under the synergistic effect of Nrf2/ARE pathway and gut flora in db/db mice and HepG2 cells.
Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.
Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways.
Adipokine ZAG Alters Depression-Like Behavior by Regulating Oxidative Stress in Hippocampus.
The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Sulforaphane improves cognitive dysfunction after surgery and anesthesia in mice: The role of Keap1-Nrf2 signaling.
Acute lung inflammation induced by zinc oxide nanoparticles: Evolution and intervention via NRF2 activator.
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension.
Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation.
Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance.
Melatonin Nuclear Receptors Mediate Green-and-Blue-Monochromatic-Light-Combinations-Inhibited B Lymphocyte Apoptosis in the Bursa of Chickens via Reducing Oxidative Stress and Nfκb Expression.
D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation.
Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway.
Relationship between Neuroprotective Effects and Structure of Procyanidins.
MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis.
Activation of Nrf2/HO-1 Antioxidant Pathway by Heme Attenuates Calcification of Human Lens Epithelial Cells.
Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
Notoginsenoside R1 Protects Against High Glucose-Induced Cell Injury Through AMPK/Nrf2 and Downstream HO-1 Signaling.
SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production.
Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway.
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Nicotinic Acid against Acetaminophen-Induced Hepatotoxicity via Sirt1/Nrf2 Antioxidative Pathway in Mice.
Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways.
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Metabolic Activation of Retrorsine may Disrupt Bile Acid Homeostasis in Mice through the Nrf2 Pathway.
Nrf2 Activation Attenuates Chronic Constriction Injury-Induced Neuropathic Pain via Induction of PGC-1α-Mediated Mitochondrial Biogenesis in the Spinal Cord.
Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway.
Zisheng Shenqi Decoction Ameliorates Monosodium Urate-Mediated Gouty Arthritis in Rats via Promotion of Autophagy through the AMPK/mTOR Signaling Pathway.
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
MCU That Is Transcriptionally Regulated by Nrf2 Augments Malignant Biological Behaviors in Oral Squamous Cell Carcinoma Cells.
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.
GPX4-Regulated Ferroptosis Mediates S100-Induced Experimental Autoimmune Hepatitis Associated with the Nrf2/HO-1 Signaling Pathway.
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway.
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy.
Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes.
Microglia-Derived Exosomes Improve Spinal Cord Functional Recovery after Injury via Inhibiting Oxidative Stress and Promoting the Survival and Function of Endothelia Cells.
PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa.
Gastric Electrical Pacing Reduces Apoptosis of Interstitial Cells of Cajal via Antioxidative Stress Effect Attributing to Phenotypic Polarization of M2 Macrophages in Diabetic Rats.
Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies.
Acupuncture Relieves Stress-Induced Depressive Behavior by Reducing Oxidative Stress and Neuroapoptosis in Rats.
Methylcobalamin Protects Melanocytes from H(2)O(2)-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway.
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice.
Computational Systems Pharmacology, Molecular Docking and Experiments Reveal the Protective Mechanism of Li-Da-Qian Mixture in the Treatment of Glomerulonephritis.
Analysis by Metabolomics and Transcriptomics for the Energy Metabolism Disorder and the Aryl Hydrocarbon Receptor Activation in Male Reproduction of Mice and GC-2spd Cells Exposed to PM(2.5).
Limonin Alleviates Non-alcoholic Fatty Liver Disease by Reducing Lipid Accumulation, Suppressing Inflammation and Oxidative Stress.
DPHC From Alpinia officinarum Ameliorates Oxidative Stress and Insulin Resistance via Activation of Nrf2/ARE Pathway in db/db Mice and High Glucose-Treated HepG2 Cells.
Menthol Targeting AMPK Alleviates the Inflammatory Response of Bovine Mammary Epithelial Cells and Restores the Synthesis of Milk Fat and Milk Protein.
Enhancing Fatty Acids Oxidation via L-Carnitine Attenuates Obesity-Related Atrial Fibrillation and Structural Remodeling by Activating AMPK Signaling and Alleviating Cardiac Lipotoxicity.
Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice.
Induction of Mitosis Delay and Apoptosis by CDDO-TFEA in Glioblastoma Multiforme.
Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell.
Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival.
Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway.
Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets.
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
The Protective Effects of Sulforaphane on High-Fat Diet-Induced Obesity in Mice Through Browning of White Fat.
Tanshinone I Inhibits Oxidative Stress-Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling.
The Protective Effects of Shengmai Formula Against Myocardial Injury Induced by Ultrafine Particulate Matter Exposure and Myocardial Ischemia are Mediated by the PI3K/AKT/p38 MAPK/Nrf2 Pathway.
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Nrf2 Down-Regulation by Camptothecin Favors Inhibiting Invasion, Metastasis and Angiogenesis in Hepatocellular Carcinoma.
Daphnetin inhibits spinal glial activation via Nrf2/HO-1/NF-κB signaling pathway and attenuates CFA-induced inflammatory pain.
Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis.
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells.
TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway.
Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs.
Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway.
N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells.
CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling.
Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism.
Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway.
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2.
LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1.
Black raspberry (Rubus occidentalis) attenuates inflammatory markers and vascular endothelial dysfunction in Wistar rats fed a high-fat diet with fructose solution.
Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke.
A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway.
The Potential Protective Effect and Possible Mechanism of Peptides from Oyster (Crassostrea hongkongensis) Hydrolysate on Triptolide-Induced Testis Injury in Male Mice.
Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells.
RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma.
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress.
Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury.
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Protective effects of Nrf2 against sepsis-induced hepatic injury.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Nicotinamide improves NAD(+) levels to protect against acetaminophen-induced acute liver injury in mice.
Loss of PHLDA1 has a protective role in OGD/R-injured neurons via regulation of the GSK-3β/Nrf2 pathway.
Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis.
The role of Nrf2 pathway in alleviating fluorine-induced apoptosis by different selenium sources in the chicken duodenum and jejunum.
Chemical Constituents from the Rhizome of Ligusticum chuanxiong Hort. and Their Nrf2 Inducing Activity.
Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress.
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via activation of Nrf2.
Cynaropicrin Induces Cell Cycle Arrest and Apoptosis by Inhibiting PKM2 to Cause DNA Damage and Mitochondrial Fission in A549 Cells.
Ripened Pu-Erh Tea Improved the Enterohepatic Circulation in a Circadian Rhythm Disorder Mice Model.
Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization.
Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway.
Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway.
Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer.
Erythritol Improves Nonalcoholic Fatty Liver Disease by Activating Nrf2 Antioxidant Capacity.
Effective-component compatibility of Bufei Yishen formula protects COPD rats against PM2.5-induced oxidative stress via miR-155/FOXO3a pathway.
Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury.
Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage.
Trojan Horse Delivery of 4,4'-Dimethoxychalcone for Parkinsonian Neuroprotection.
Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation.
Expression of COX-2 and Nrf2/GPx3 in the anterior vaginal wall tissues of women with pelvic organ prolapse.
Protective effects of gastrodin pretreatment on mouse hepatic ischemia-reperfusion occurring through antioxidant and anti-apoptotic mechanisms.
Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.
Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities.
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca(2+)/CaMKII/Nrf2 signaling pathway.
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Upregulation of Chemoresistance by Mg(2+) Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells.
4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.
Anti-inflammatory activity of the water extract of Chloranthus serratus roots in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways.
Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia.
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit.
The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2.
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Cordyceps acid alleviates lung cancer in nude mice.
Chondrocyte ferroptosis contribute to the progression of osteoarthritis.
Gambogic acid ameliorates high glucose- and palmitic acid-induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo.
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Oxidative stress in retrotrapezoid nucleus/parafacial respiratory group and impairment of central chemoreception in rat offspring exposed to maternal cigarette smoke.
Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARγ pathway against oxidative injury in mice hippocampus.
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal Muscle Fiber Atrophy during Simulated Microgravity.
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-κB and Nrf2 pathways.
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.
Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway.
Troxerutin Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.
Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Upregulation of antioxidant and autophagy pathways via NRF2 activation protects spinal cord neurons from ozone damage.
Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury.
Ginkgo biloba delays light-induced photoreceptor degeneration through antioxidant and antiapoptotic properties.
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease.
Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis.
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
Effect of Chronic Stress Present in Fibroblasts Derived from Patients with a Sporadic Form of AD on Mitochondrial Function and Mitochondrial Turnover.
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
The piperine derivative HJ105 inhibits Aβ(1-42)-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.
Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling.
Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum.
Exosomes are involved in total body irradiation-induced intestinal injury in mice.
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Increased lipid peroxidation by graphene quantum dots induces ferroptosis in macrophages.
Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice.
Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis.
Choline attenuates heat stress-induced oxidative injury and apoptosis in bovine mammary epithelial cells by modulating PERK/Nrf-2 signaling pathway.
Baicalin-loaded macrophage-derived exosomes ameliorate ischemic brain injury via the antioxidative pathway.
Tolerable upper intake level of iron damages the liver of weaned piglets.
Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer's disease.
Chlamydia trachomatis Pgp3 protein regulates oxidative stress via activation of the Nrf2/NQO1 signal pathway.
Proteomics analysis in the kidney of mice following oral feeding Realgar.
The role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence.
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Salvinorin A protects against methicillin resistant staphylococcus aureus-induced acute lung injury via Nrf2 pathway.
Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis.
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
RNA-seq reveals novel cancer-selective and disease subtype-independent mechanistic targets of withaferin A in human breast cancer cells.
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I.
Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT.
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
The Time-Course of Antioxidant Irisin Activity: Role of the Nrf2/HO-1/HMGB1 Axis.
Klotho ameliorates diabetic nephropathy by activating Nrf2 signaling pathway in podocytes.
Dietary alpha-lipoic acid supplementation improves spermatogenesis and semen quality via antioxidant and anti-apoptotic effects in aged breeder roosters.
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration.
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress.
H(2)S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434.
Exercise reduces hyperlipidemia-induced kidney damage in apolipoprotein E-deficient mice.
Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage.
Marine algal polysaccharides alleviate aflatoxin B1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers.
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress.
Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice.
Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway.
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
ATF3 regulates oxidative stress and extracellular matrix degradation via p38/Nrf2 signaling pathway in pelvic organ prolapse.
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway.
Dimethyl fumarate ameliorates endotoxin-induced acute kidney injury against macrophage oxidative stress.
Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway.
Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the Akt-GSK3β and Nrf2-Keap1-HO-1 pathways in vitro and in vivo murine models of Alzheimer's disease.
Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer.
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.
MicroRNA miR-106a-5p targets forkhead box transcription factor FOXC1 to suppress the cell proliferation, migration, and invasion of ectopic endometrial stromal cells via the PI3K/Akt/mTOR signaling pathway.
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens.
Lack of Type I Interferon Signaling Ameliorates Respiratory Syncytial Virus-Induced Lung Inflammation and Restores Antioxidant Defenses.
A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD(2)-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus.
Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.
Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.
Fucoxanthin regulates Nrf2 signaling to decrease oxidative stress and improves renal fibrosis depending on Sirt1 in HG-induced GMCs and STZ-induced diabetic rats.
Lactoferrin Alleviates Acute Alcoholic Liver Injury by Improving Redox-Stress Response Capacity in Female C57BL/6J Mice.
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.
Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway.
Glutaredoxin 1 protects neurons from oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3β/Nrf2 signaling.
The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
PLK2 protects retinal ganglion cells from oxidative stress by potentiating Nrf2 signaling via GSK-3β.
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis.
Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death.
The in vitro and in vivo study of oleanolic acid indole derivatives as novel anti-inflammatory agents: Synthesis, biological evaluation, and mechanistic analysis.
Isoeucommin A attenuates kidney injury in diabetic nephropathy through the Nrf2/HO-1 pathway.
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway.
Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism.
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl(4)-induced liver injury in vivo.
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer.
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
PSMD12 promotes glioma progression by upregulating the expression of Nrf2.
Silicon Oxynitrophosphide Nanoscale Coating Enhances Antioxidant Marker-Induced Angiogenesis During in vivo Cranial Bone-Defect Healing.
Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.
Myricetin protects against H(2) O(2) -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.
Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy.
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Heme-Mediated Activation of the Nrf2/HO-1 Axis Attenuates Calcification of Valve Interstitial Cells.
AKR1B10 negatively regulates autophagy through reducing GAPDH upon glucose starvation in colon cancer.
Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κB Pathway.
Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by Aβ (25-35) and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.
Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2.
Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells.
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
The Nrf2/PGC1α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer.
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation.
Comparative effectiveness of 4 natural and chemical activators of Nrf2 on inflammation, oxidative stress, macrophage polarization, and bactericidal activity in an in vitro macrophage infection model.
Mechanisms and therapeutic implications of RTA 408, an activator of Nrf2, in subarachnoid hemorrhage-induced delayed cerebral vasospasm and secondary brain injury.
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo.
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Rutaecarpine Ameliorates Ethanol-Induced Gastric Mucosal Injury in Mice by Modulating Genes Related to Inflammation, Oxidative Stress and Apoptosis.
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.
Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling.
Formononetin Attenuates Airway Inflammation and Oxidative Stress in Murine Allergic Asthma.
α-Cyperone Attenuates H(2)O(2)-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2.
Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling.
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Kaempferol Protects Blood Vessels From Damage Induced by Oxidative Stress and Inflammation in Association With the Nrf2/HO-1 Signaling Pathway.
Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle.
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
Sp4 controls constitutive expression of neuronal serine racemase and NF-E2-related factor-2 mediates its induction by valproic acid.
Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy.
PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway.
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Cholestasis Differentially Affects Liver Connexins.
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Astaxanthin attenuates oxidative stress and immune impairment in D-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway.
(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis.
NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest.
Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study.
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Liraglutide Up-regulation Thioredoxin Attenuated Müller Cells Apoptosis in High Glucose by Regulating Oxidative Stress and Endoplasmic Reticulum Stress.
Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway.
MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
MiR-23a-5p exacerbates intestinal ischemia-reperfusion injury by promoting oxidative stress via targeting PPAR alpha.
Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway.
Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage.
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Tanshinone IIA attenuates acetaminophen-induced hepatotoxicity through HOTAIR-Nrf2-MRP2/4 signaling pathway.
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D(3) Plus Nicotine.
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.
Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease.
Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway.
Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.
Upregulation of Glutaredoxin 2 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and ROS production in neurons by enhancing Nrf2 signaling via modulation of GSK-3β.
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.
Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.
A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation.
Crocin ameliorates arsenic trioxide‑induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis.
Down-regulation of miR-383-5p suppresses apoptosis in oxidative stress rat hepatocytes by targeting Bcl2.
Two resveratrol analogs, pinosylvin and 4,4'-dihydroxystilbene, improve oligoasthenospermia in a mouse model by attenuating oxidative stress via the Nrf2-ARE pathway.
Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice.
Anthocyanins decrease the internalization of TiO(2) nanoparticles into 3D Caco-2 spheroids.
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Mutual antagonism between indoleamine 2,3-dioxygenase 1 and nuclear factor E2-related factor 2 regulates the maturation status of DCs in liver fibrosis.
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis.
Hesperidin ameliorates hypobaric hypoxia-induced retinal impairment through activation of Nrf2/HO-1 pathway and inhibition of apoptosis.
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways.
Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury.
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation.
Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds.
Anti-Inflammatory Effects of Lasia spinosa Leaf Extract in Lipopolysaccharide-Induced RAW 264.7 Macrophages.
Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions.
Spinosin Inhibits Aβ(1-42) Production and Aggregation via Activating Nrf2/HO-1 Pathway.
6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway.
Mesenchymal stromal cells ameliorate acute lung injury induced by LPS mainly through stanniocalcin-2 mediating macrophage polarization.
NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes.
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice.
Nardosinanone N suppresses LPS-induced macrophage activation by modulating the Nrf2 pathway and mPGES-1.
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCF(β-TRCP)-Mediated Degradation of NRF2 in Pancreatic Cancer.
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway.
Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation.
Polydatin ameliorates chemotherapy-induced cognitive impairment (chemobrain) by inhibiting oxidative stress, inflammatory response, and apoptosis in rats.
HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.
Sulforaphane reduces intracellular survival of Staphylococcus aureus in macrophages through inhibition of JNK and p38 MAPK‑induced inflammation.
Exogenous Hydrogen Sulfide Regulates Mycoplasma pneumoniae Lipid-Associated Membrane Proteins to Induce Expression of Heme Oxygenase-1 and Proinflammatory Cytokines.
Protective effect of apigenin on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation.
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways.
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.
Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice.
Stomatin-like protein-2 confers neuroprotection effect in oxygen-glucose deprivation/reoxygenation-injured neurons by regulating AMPK/Nrf2 signalling.
MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells.
Luteolin alleviates ochratoxin A induced oxidative stress by regulating Nrf2 and HIF-1α pathways in NRK-52E rat kidney cells.
Downregulation of RKIP promotes radioresistance of nasopharyngeal carcinoma by activating NRF2/NQO1 axis via downregulating miR-450b-5p.
Piceatannol Ameliorates Hepatic Oxidative Damage and Mitochondrial Dysfunction of Weaned Piglets Challenged with Diquat.
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Hydrogen gas protects against delayed encephalopathy after acute carbon monoxide poisoning in a rat model.
Inhibition of the Keap1-Nrf2 protein-protein interaction protects retinal cells and ameliorates retinal ischemia-reperfusion injury.
The expression of p-p62 and nuclear Nrf2 in esophageal squamous cell carcinoma and association with radioresistance.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
HIPK2 overexpression relieves hypoxia/reoxygenation-induced apoptosis and oxidative damage of cardiomyocytes through enhancement of the Nrf2/ARE signaling pathway.
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway.
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.
Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries.
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Protective effect of Liraglutide on diabetic retinal neurodegeneration via inhibiting oxidative stress and endoplasmic reticulum stress.
Evaluation and Exploration of Potentially Bioactive Peptides in Casein Hydrolysates against Liver Oxidative Damage in STZ/HFD-Induced Diabetic Rats.
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Syringin protects against colitis by ameliorating inflammation.
Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress.
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H(2)O(2)-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice.
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl(4)-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Oxidative stress-mediated hepatotoxicity in rats induced by ethanol extracts of different parts of Chloranthus serratus.
Resveratrol improves meat quality, muscular antioxidant capacity, lipid metabolism and fiber type composition of intrauterine growth retarded pigs.
Functional Food XingJiuTang Attenuates Alcohol-Induced Liver Injury by Regulating SIRT1/Nrf-2 Signaling Pathway.
Curcumin-cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress.
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis.
Hylocereus polyrhizus Peel Extract Retards Alcoholic Liver Disease Progression by Modulating Oxidative Stress and Inflammatory Responses in C57BL/6 Mice.
TRIM16 protects human periodontal ligament stem cells from oxidative stress-induced damage via activation of PICOT.
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain.
Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.
Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice.
Effects of Launaea sarmentosa Extract on Lipopolysaccharide-Induced Inflammation via Suppression of NF-κB/MAPK Signaling and Nrf2 Activation.
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Silychristin A activates Nrf2-HO-1/SOD2 pathway to reduce apoptosis and improve GLP-1 production through upregulation of estrogen receptor α in GLUTag cells.
l-Arginine Inhibits Apoptosis of Ovine Intestinal Epithelial Cells through the l-Arginine-Nitric Oxide Pathway.
Dandelion Extract Alleviated Lipopolysaccharide-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.
Protective effect of Dioscorea zingiberensis ethanol extract on the disruption of blood-testes barrier in high-fat diet/streptozotocin-induced diabetic mice by upregulating ZO-1 and Nrf2.
Long noncoding RNA TUG1 regulates prostate cancer cell proliferation, invasion and migration via the Nrf2 signaling axis.
Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis.
4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease.
Maternal curcumin supplementation ameliorates placental function and fetal growth in mice with intrauterine growth retardation†.
Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses.
Compensatory upregulation of aldo-keto reductase 1B10 to protect hepatocytes against oxidative stress during hepatocarcinogenesis.
SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway.
Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells.
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway.
CCl(4)-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Effects of Ethyl Pyruvate on Bile Duct Ligation-Induced Liver Fibrosis by Regulating Nrf2 Pathway and Proinflammatory Cytokines in Rats.
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.
Ellagic acid supports neuron by regulating astroglia Nrf2.
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway.
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Lysosomal dysfunction is associated with persistent lung injury in dams caused by pregnancy exposure to carbon black nanoparticles.
Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo.
Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2-HMOX1 axis.
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress.
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
Botrysphin D attenuates arsenic-induced oxidative stress in human lung epithelial cells via activating Nrf2/ARE signaling pathways.
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Neuroprotection of Andrographolide Against Microglia-Mediated Inflammatory Injury and Oxidative Damage in PC12 Neurons.
Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss.
The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.
MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
The roles of Nrf2 and autophagy in modulating inflammation mediated by TLR4 - NFκB in A549 cell exposed to layer house particulate matter 2.5 (PM(2.5)).
Spinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats.
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation.
Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis.
Chitosan Oligosaccharide Attenuates Nonalcoholic Fatty Liver Disease Induced by High Fat Diet through Reducing Lipid Accumulation, Inflammation and Oxidative Stress in C57BL/6 Mice.
Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1.
Protective effect of dihydroartemisinin in inhibiting senescence of myeloid-derived suppressor cells from lupus mice via Nrf2/HO-1 pathway.
S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.
The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice.
Hydrogen sulfide ameliorates disorders in the parafacial respiratory group region of neonatal rats caused by prenatal cigarette smoke exposure via an antioxidative effect.
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signalling pathway and prevents oxidative insults in human lung epithelial cells.
Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production.
Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β(1)/Smad(2)/Nrf(2)-NOX(4) signaling pathways.
Neuroprotective Effect of Dioscin on the Aging Brain.
Synthesis and biological activities of petrosiols B and D.
Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells.
Inhibition of SGK1 confers vulnerability to redox dysregulation in cervical cancer.
Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome.
Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions.
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway.
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats.
Naringenin targets on astroglial Nrf2 to support dopaminergic neurons.
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde.
Differential response to lead toxicity in rat primary microglia and astrocytes.
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1β and promoting Nrf2/HO-1.
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary.
Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor.
Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
Punicalagin Reversed the Hepatic Injury of Tetrachloromethane by Antioxidation and Enhancement of Autophagy.
Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer.
Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling.
Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation.
Curcumin Alleviates IUGR Jejunum Damage by Increasing Antioxidant Capacity through Nrf2/Keap1 Pathway in Growing Pigs.
Water-separated part of Chloranthus serratus alleviates lipopolysaccharide- induced RAW264.7 cell injury mainly by regulating the MAPK and Nrf2/HO-1 inflammatory pathways.
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.
Discovery of coumarin-derived imino sulfonates as a novel class of potential cardioprotective agents.
Dietary Dihydroartemisinin Supplementation Attenuates Hepatic Oxidative Damage of Weaned Piglets with Intrauterine Growth Retardation through the Nrf2/ARE Signaling Pathway.
Protective Effects of Fucoidan against Hydrogen Peroxide-Induced Oxidative Damage in Porcine Intestinal Epithelial Cells.
Icariin targets Nrf2 signaling to inhibit microglia-mediated neuroinflammation.
(-)-Epicatechin mitigates radiation-induced intestinal injury and promotes intestinal regeneration via suppressing oxidative stress.
Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
KLF15 regulates endobiotic and xenobiotic metabolism.
Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner.
Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1.
A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis.
Fangchinoline Ameliorates the Expressions of Angiogenic Molecule in Cerebral Ischemia Induced Neuronal Degeneration in Neonatal Rats.
Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats.
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Hepatoprotective Activity of the Ethanolic Extract of Polygonum multiflorum Thunb. against Oxidative Stress-Induced Liver Injury.
Nrf2 protects stellate cells from Smad-dependent cell activation.
Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia.
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Local low dose curcumin treatment improves functional recovery and remyelination in a rat model of sciatic nerve crush through inhibition of oxidative stress.
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Enhanced anti-obesity effects of bacterial cellulose combined with konjac glucomannan in high-fat diet-fed C57BL/6J mice.
Renoprotective Effects of Antroquinonol in Rats with N(ω)-Nitro-l-Arginine Methyl Ester-Induced Hypertension.
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice.
Anti-neovascularization effects of DMBT in age-related macular degeneration by inhibition of VEGF secretion through ROS-dependent signaling pathway.
Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks.
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
Exposure to formaldehyde and diisononyl phthalate exacerbate neuroinflammation through NF-κB activation in a mouse asthma model.
Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model.
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis.
Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge.
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
LncRNA MT1DP Aggravates Cadmium-Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR-365.
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.
β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice.
Activation of Nrf2 might reduce oxidative stress in human granulosa cells.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
A small molecule targeting glutathione activates Nrf2 and inhibits cancer cell growth through promoting Keap-1 S-glutathionylation and inducing apoptosis.
Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-β1/Smad3 Pathway.
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus.
Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea.
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer.
Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications.
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.
Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia.
Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways.
Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1.
TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity.
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms.
Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway.
The effect of hydrogen sulfide-releasing naproxen (ATB-346) versus naproxen on formation of stress-induced gastric lesions, the regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation.
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Carbon monoxide released from its pharmacological donor, tricarbonyldichlororuthenium (II) dimer, accelerates the healing of pre-existing gastric ulcers.
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H(2)S system: Role of oxidative stress and endoplasmic reticulum stress.
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
Fibroblast growth factor-2-mediated protection of cardiomyocytes from the toxic effects of doxorubicin requires the mTOR/Nrf-2/HO-1 pathway.
An inducible form of Nrf2 confers enhanced protection against acute oxidative stresses in RPE cells.
SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis.
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway.
Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats.
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.
Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo.
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells.
Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD).
Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway.
NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway.
Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.
Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway.
(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Protective Effects of Hydrogen Sulfide in the Ageing Kidney.
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats.
Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice.
3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice.
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.
Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.
Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice.
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
Resveratrol Ameliorated Vascular Calcification by Regulating Sirt-1 and Nrf2.
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Taurine protects against As2O3-induced autophagy in pancreas of rat offsprings through Nrf2/Trx pathway.
Transcriptional upregulation centra of HO-1 by EGB via the MAPKs/Nrf2 pathway in mouse C2C12 myoblasts.
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Potent effects of dioscin against obesity in mice.
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Zhang M, Liu Y, Ma W, Wang J, He N, Song H, Gu Y, Yang M, Lu X, Sun J, Xu C, Du L, Yuan Y, Wang Y, Ji K, Liu Q
International journal of biological sciences 2026;22(5):2581-2602
International journal of biological sciences 2026;22(5):2581-2602
Identification of autophagy-related key biomarkers in caerulein induced acute pancreatitis: In silico and in vivo study.
Shen X, Yao J, Wang Z, Chen R, Li L, Xu X, Huang Y
PloS one 2026;21(3):e0344110
PloS one 2026;21(3):e0344110
SHP2 improved Late-onset fetal growth restriction via modulating ROS/BRD4/PI3K/YAP/PIGF signaling induced angiogenesis.
Li F, Li Y, Hao W, Zhang X, Shen X, Yang B, Zhang W, Fu L, Gu S
PloS one 2026;21(2):e0342649
PloS one 2026;21(2):e0342649
Combined polyphenols in Psidium guajava-citrus limon leaf extract attenuate fructose-induced cardiac injury by modulating metabolic and oxidative stress pathways in rats.
Essa HA, ElMosbah DE, Fahmy HA
PloS one 2026;21(1):e0339641
PloS one 2026;21(1):e0339641
Bioinformatic Identification and Preliminary Validation of TP53, TGFB1, and NFE2L2 as Potential Ferroptosis-Related Regulators in Pancreatic Adenocarcinoma.
Li S, Zhang C, Lv S, Zhang Z, Xu D, Xu T
Pharmacogenomics and personalized medicine 2026;19:562602
Pharmacogenomics and personalized medicine 2026;19:562602
Cinnamaldehyde attenuates LPS-induced acute kidney injury by inhibiting ferroptosis via the Gsk3β/Nrf2/Gpx4 pathway.
Han W, Sun H, Tian Z, Wang Y, Tian H, Tian Y
American journal of translational research 2026;18(1):498-511
American journal of translational research 2026;18(1):498-511
Akkermansia muciniphila alleviates antibiotic- and LPS-induced oxidative stress via the p38α MAPK-Nrf2 signaling axis.
Ye WY, Feng CX, Su SQ, Wei SM, Mao Y, Chen ZY, Su Y, Shan QW
Frontiers in microbiology 2026;17:1753421
Frontiers in microbiology 2026;17:1753421
Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury.
Yao M, Wang X, Wei H, Wang L, Zhang D, Liang Z, He R, He Y, Jiang L, Cui Y
Frontiers in pharmacology 2026;17:1716078
Frontiers in pharmacology 2026;17:1716078
SMURF2 attenuates NRF2-driven tumor progression by acting as a nuclear brake on NRF2 during cellular stress.
Xu W, Dong L, Li J, Fan S, Wang Y, Xia Q
Redox biology 2026 May;92:104102
Redox biology 2026 May;92:104102
Asperuloside-Mediated Activation of Nrf2 Inhibits the NF-κB Pathway and Suppresses Osteoarthritis Progression.
Zhu L, Shen H, Huang C, Jiang H, Yan Z, Pan X, Lu Z
Phytotherapy research : PTR 2026 May;40(5):3027-3046
Phytotherapy research : PTR 2026 May;40(5):3027-3046
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Xu H, Li Y, Wang J, Xin Y, Xu Q, Qin X, Yang X, Yan Y, Chen Q, Chen Y, Zhang Y, Lu C, Xu K, Wang X
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Luteoloside attenuates renal Ischemia-Reperfusion injury by suppressing ferroptosis through disruption of the KEAP1-NRF2 interaction.
Qiu Q, Zhou Y, Xia K, Yan Z, Hui Y, Chen Z, Yu B, Zhu J, Qiu T, Zhou J, Zhang Y, Wang T
Free radical biology & medicine 2026 May;248:177-193
Free radical biology & medicine 2026 May;248:177-193
Indole-3-carbinol attenuates cisplatin-induced premature ovarian failure by activating Nrf2 through competitive binding of Keap1.
Zhu F, Zhang R, He Z, Zhang N, Li F, Li J, Chen H, Liu X, Cheng L, Zhong F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158040
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158040
g-C(3)N(4) Nanosheets as a Ferroptosis-Targeted Nanoprobe: Mitigating Iron Overload and Restoring Male Fertility via Nrf2 Pathway Activation.
Wang L, Yang F, Ye Z, Lu R, Wei J, Liu M, Chen G, Ding W
Molecular pharmaceutics 2026 May 4;23(5):2857-2870
Molecular pharmaceutics 2026 May 4;23(5):2857-2870
Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2/ROS/NLRP3 axis and modulation of the gut microbiota.
Qiu M, Yi Q, Luo M, Duan S, Zhang Z, Wu X, Chen T, Ma C, Cui T, Zhang B, Zhang Y, Li J, Guo S, Gao Y, Zhang D
Journal of ethnopharmacology 2026 May 23;363:121373
Journal of ethnopharmacology 2026 May 23;363:121373
NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way.
Qiu Z, Lin Y, Chen S, Cao W, Yang J, Li R, Chen Y, Yao X, Fu S, Jin N
iScience 2026 May 15;29(5):115484
iScience 2026 May 15;29(5):115484
Prenylterphenyllin, a regulator of P53, inhibits colorectal cancer progression through oxidative stress and energy metabolism pathway.
Zhang Y, Han Y, Li S, Shan R, Lin L, Gu Z, Wang R, Chen Y, Xiao J, An F, Hu C, He C
Redox biology 2026 Mar;90:103993
Redox biology 2026 Mar;90:103993
Ciliary IFT88 inhibits intervertebral disc degeneration under excessive mechanical stress by regulating endplate cartilage calcification.
Dong ZR, Wang J, Huang YK, Ding W, He HX, Yuan GC, Gao ZY, Ge YX, Wang WX, Jiang LB, Zhao MD
Journal of advanced research 2026 Mar;81:157-173
Journal of advanced research 2026 Mar;81:157-173
Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation.
Zhang R
International journal of molecular medicine 2026 Mar;57(3)
International journal of molecular medicine 2026 Mar;57(3)
Cell-penetrating peptide-functionalized biomimetic nanovesicles for efficient cataract treatment via enhanced corneal penetration and lens-mitochondria dual targeting.
Zhang R, Li W, Wang J, Li Y, Chen J, Hong W, Huang H, Lin Q
Bioactive materials 2026 Mar;57:305-322
Bioactive materials 2026 Mar;57:305-322
Differential regulation of radioadaptation by quercetin between human normal and cancer cells.
Li C, Li X, Biemans R, Zhang R, Zhang M, Dubois LJ
Clinical and translational radiation oncology 2026 Mar;57:101099
Clinical and translational radiation oncology 2026 Mar;57:101099
Concurrent Ferroptosis and Apoptosis in Resveratrol-Treated Glioblastoma Cells: Relevance With NRF2 Downregulation and Oxidative Stress.
Farman A, Zheng X, Wu ML, Hong L, Qian W, Liu J
Cell biology international 2026 Mar;50(3):e70153
Cell biology international 2026 Mar;50(3):e70153
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis.
Chen Y, Shi WQ, Zhang P, Wang R, Ye WB, Lin GQ, Peng SJ, Zhang JG
Acta pharmacologica Sinica 2026 Mar;47(3):576-592
Acta pharmacologica Sinica 2026 Mar;47(3):576-592
Amygdalin synergizes with the TNF-α monoclonal antibody infliximab to modulate HSP90 and related necro-inflammatory/oxidative stress pathways in a rat model of hepatic I/R.
Mohamed RA, Ghoneim ME, Tawfiq RA, El Sayed NF
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar;399(5):7643-7657
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar;399(5):7643-7657
Role of connexin32 in zinc oxide nanoparticles induced hepatotoxicity.
Wei E, Wu L, Xia G, Zhong Y, Li LG, Chen H, Tang N
Toxicology mechanisms and methods 2026 Mar;36(3):403-411
Toxicology mechanisms and methods 2026 Mar;36(3):403-411
Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway
.
Li P, Wan X, Li W, Cheng D, Yang Y, Wang Y, Zhu R, Chen Y, Liu H, Zhang Z
Molecular medicine reports 2026 Mar;33(3)
Molecular medicine reports 2026 Mar;33(3)
Faecalibacterium prausnitzii suppresses ovarian cancer by inducing ferroptosis via phenylalanine metabolism activation.
Ding K, Huo Y, Fu K, Chen Y, Xia L, Zhan J, Liu J, Liu J, Liu Y, Zhang M, Wu X, Choe H, Zhao D, Ma J, Dai C, Yu Z, Peng Y, Ma X, Zhang L
Microbiological research 2026 Mar;304:128342
Microbiological research 2026 Mar;304:128342
MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment.
Lin R, Mo Y, Barrows D, Mei W, Onikubo T, Sun J, Zhang Z, Apostolou E, Tavazoie SF, Roeder RG
Nature chemical biology 2026 Mar;22(3):501-513
Nature chemical biology 2026 Mar;22(3):501-513
Astaxanthin alleviates DSS-induced ulcerative colitis in mice associated with Nrf2-mediated ferroptosis independently of gut microbiota modulation.
Wei MX, Wu XY, Lin JW, Huang JY, Cheng J, Huang WF, Xu GH, Yi LT
The Journal of nutritional biochemistry 2026 Mar;149:110212
The Journal of nutritional biochemistry 2026 Mar;149:110212
Traditional Chinese Herbal Formula XuMingZhuSan Alleviates Neuronal Ferroptosis in Rats After Stroke by Activating the NRF2/GPX4/SLC7A11 Pathway.
Liu X, Wang C, Han L, Xiao Y, Yu H, Hu Z, Fei X, Peng M, Zhou J, Zhong Z
Food science & nutrition 2026 Mar;14(3):e71495
Food science & nutrition 2026 Mar;14(3):e71495
Cascade Therapy of Periodontitis via Sequential Release of Ribosome-Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF-Based System.
Chen Y, Xu Z, Xue Y, Liu S, Zhang X, Guo J, Yao M, Liu Y, Lu X, Qian J, Ma Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e21553
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e21553
ANO6 Confers Paclitaxel Resistance by Targeting Ferroptosis in Cervical Cancer.
Cao Y, Peng Y, Shen J
BioFactors (Oxford, England) 2026 Mar-Apr;52(2):e70070
BioFactors (Oxford, England) 2026 Mar-Apr;52(2):e70070
Targeting the FTO-ACSL4 Pathway: A Novel Mechanism for Sanguinarine Chloride-Induced Ferroptosis in Endometrial Cancer.
Li W, Liu S, Wang K, Lu J, Fu S, Li L, Tao Y
Biomedicines 2026 Mar 9;14(3)
Biomedicines 2026 Mar 9;14(3)
Anti-Inflammatory Effects of Curcumin via the Nrf2-cGAS-STING-NF-κB Pathway in MH7A Rheumatoid Arthritis Fibroblast-like Synoviocytes.
Li L, Shen T, Li Z, Guo Q, Pang Q
Biomedicines 2026 Mar 9;14(3)
Biomedicines 2026 Mar 9;14(3)
Boron Triggers Hepatic Ferroptosis: Unveiling the Dual-Pathogenic Nexus of Oxidative Stress and SLC7A11/GPX4 Dysregulation.
He T, Li Y, Huang J, Su W, Liu S, Quan J, Zhong G, Liu Z, Shi D, Yu W
Animals : an open access journal from MDPI 2026 Mar 6;16(5)
Animals : an open access journal from MDPI 2026 Mar 6;16(5)
Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis.
Zhang S, Li X, Gao Y, Dong Q, Jin X, Shi P, Dong J
Fish physiology and biochemistry 2026 Mar 5;52(2)
Fish physiology and biochemistry 2026 Mar 5;52(2)
MyD88 inhibitory Peptide-2 (MIP2) improves neurological outcomes and reduces neuroinflammation after intracerebral Hemorrhage-mediated secondary brain injury.
Siddique R, Guo P, Wang Q, Su Q, Qi L, Mazhar M, Aaqib M, Zhang X, Khan S, Yong VW, Xue M
Journal of advanced research 2026 Mar 23;
Journal of advanced research 2026 Mar 23;
High-Intensity Interval Training Outperforms Moderate-Intensity Exercise in Hyperlipidemic ApoE⁻/⁻ Mice: A Molecular and Histological Comparison.
Qian C, Pei Z, Yang Z, Sun M, Zhang Y, Liu H, Sun Y
Frontiers in bioscience (Landmark edition) 2026 Mar 20;31(3):47751
Frontiers in bioscience (Landmark edition) 2026 Mar 20;31(3):47751
USP1 promotes hepatocellular carcinoma progression by modulating mitophagy via stabilizing MCM3 to regulate the Keap1-Nrf2 axis.
Chen Z, Sun C, Wang Y, Duan X, Ma H, Zhou X, Chen S, Peng P
iScience 2026 Mar 20;29(3):114927
iScience 2026 Mar 20;29(3):114927
Retinoic Acid Alleviates TGEV-Induced Ferroptosis by Activating the p62-NRF2-GPX4/HO-1 Pathway and Iron Metabolism in Intestinal Epithelial Cells.
Yin C, Lai X, Pu J, Liu C, Luo Y, He J, Yu B, Che L, Wang Q, Wang H, Chen D, Wu A
Nutrients 2026 Mar 20;18(6)
Nutrients 2026 Mar 20;18(6)
EGCG Derivatives Alleviate Diquat-Induced Liver and Gut Damage in Mice by Activating an Antioxidant Pathway and Enhancing Barrier Function.
Xu L, Luo C, Gao X, Yuan J, Fu B
Animals : an open access journal from MDPI 2026 Mar 19;16(6)
Animals : an open access journal from MDPI 2026 Mar 19;16(6)
NUAK1 silencing enhances radiotherapy-induced ferroptosis in locally advanced rectal cancer by impairing Nrf2-driven transcription of GPX4.
Zhuang Z, Guan B, Wang Y, Lin X, Cai H, Chen B, Li S, Liu X, Zhuang J, Guan G
Cellular oncology (Dordrecht, Netherlands) 2026 Mar 18;49(2)
Cellular oncology (Dordrecht, Netherlands) 2026 Mar 18;49(2)
CXCL12 Promotes Peripheral Nerve Injury Repair by Inhibiting the Ferroptosis-Inflammation Axis via the ERK/Nrf2 Pathway.
Yuan Y, Jiang Y, Du S, Yuan G, Yang Z, Wang P
Inflammation 2026 Mar 12;49(1)
Inflammation 2026 Mar 12;49(1)
NRF2 deficiency impairs proliferation and survival of chicken primordial germ cells via oxidative stress, mitochondrial dysfunction and apoptosis.
Niu YJ, Yuan G, Ren W, Wu J, Liu G, Zou M, Wang X, Diao Y, Zhang N, Li G, Han W, Cui XS, Chen G, Li B
Poultry science 2026 Mar 12;105(6):106765
Poultry science 2026 Mar 12;105(6):106765
Bellidifolin mitigates doxorubicin-induced myocardial injury via regulating oxidative stress, inflammation, and apoptosis: a combination of network pharmacology and experiments.
Cao Y, Jia Y, Chen R, Dai C, Ge H, Duan S, Li A, Wu J
Journal of molecular histology 2026 Mar 10;57(2)
Journal of molecular histology 2026 Mar 10;57(2)
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
Zhang K, Sun S, Qiu H, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2026 Mar 1;358:120981
Journal of ethnopharmacology 2026 Mar 1;358:120981
Ethanol extract of Gastrodia elata Blume alleviates ischemic stroke by inhibiting oxidative stress and ferroptosis through the PI3K/AKT/Nrf2 pathway.
Wang Y, Liu J, Wu W, Xue J, Mu D, Wang F, Li W, Liu Y, Liang D, Aminah NS, Chai H, Mi Y, Hou Y
Journal of ethnopharmacology 2026 Mar 1;358:120956
Journal of ethnopharmacology 2026 Mar 1;358:120956
A spinal USP7-Bach1 positive feedback loop drives NOX4-mediated ferroptosis in neuropathic pain.
Jiao B, Liu S, Zhang K, Zhang W, Cao X, Zhang X, Sun J, Xu H
Redox biology 2026 Jun;93:104153
Redox biology 2026 Jun;93:104153
A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway.
Huang N, Cao L, Xu Y, Pan L, Zheng A, Wang X, Jiang X
Bioactive materials 2026 Jun;60:574-589
Bioactive materials 2026 Jun;60:574-589
Class Effect of SGLT2 Inhibitors Against Doxorubicin-Induced Cardiotoxicity via Regulating Adenosine Kinase Mediated-Cardiac Oxidative Stress.
Yan J, Lin K, Dai S, Zhang Y, Zheng R, Shi S, Tang Z, Lai X, Huang W, Su L
Cardiovascular drugs and therapy 2026 Jun;40(3):971-985
Cardiovascular drugs and therapy 2026 Jun;40(3):971-985
Protean bio-heterojunction nanoparticle coating for dynamically modulating diabetic microenvironment.
Pan L, Zheng A, Huang N, Zhang S, Peng L, Zheng F, Cao L, Wang X, Jiang X
Biomaterials 2026 Jun;329:123912
Biomaterials 2026 Jun;329:123912
Dietary Zanthoxylum bungeanum leaves supplementation enhances antioxidant capacity through activation of Nrf2 signalling pathway in pigs.
Li W, Tang Q, Wei H, Lu Y, Wang S, Long X, Tang Z, Xu Y, Peng X, Sun Z
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2026 Jun;25:282-296
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2026 Jun;25:282-296
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Wang J, Chen P, Li Y, Wang R, Ding W, Yu R, Qin Q, Wu R, Wei W, Shi J, Yuan H, Zhuang C, Sun Y
Free radical biology & medicine 2026 Jun;249:165-179
Free radical biology & medicine 2026 Jun;249:165-179
Extracellular histone H3 induces METosis in acute liver failure by regulating the NRF2/HO-1/NQO1 pathway-mediated oxidative stress.
Zhang X, Guo J, Zhang D, Wang Y, Shi C, Gong Z
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168215
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168215
Farrerol mitigates fungal keratitis by enhancing fungal clearance and limiting inflammation through autophagy and Nrf2 pathway.
Yu B, Zhang L, Lin J, Wang Q, Chi M, Wang Z, Liu W, Wang S, Wei Z, Li C, Zhao G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158169
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158169
The Berberine Derivative BBR684 Inhibits VDAC Oligomerization to Suppress Ferroptosis in Acute Kidney Injury.
Jiang Z, Zhang W, Zhu J, Wang C, Chen G, Guo Y
Current therapeutic research, clinical and experimental 2026 Jun;104:100825
Current therapeutic research, clinical and experimental 2026 Jun;104:100825
Immune-epithelial dual-targeting bilirubin nanoparticles for acute lung injury.
Tang Y, Xu Y, Ye J, Han Y, Zhang M, Sun Y, Kang Y, Zhu S, Cai L, Wu R, Gong W, Yao Q, Duan B, Kou L, Chen R, Zhang H
Journal of controlled release : official journal of the Controlled Release Society 2026 Jun 10;394:114852
Journal of controlled release : official journal of the Controlled Release Society 2026 Jun 10;394:114852
A multimodal ROS logic-gated therapeutic platform disrupts the vicious cycle of senescence to promote aged bone defect repair.
Sun X, Xie S, Fang Y, Zhang D, Wang W, Sun Z, Lu J, Yue X, Kong W, Fu D, Xu X, Dai K, Wang J, Wei J, Sun X
Bioactive materials 2026 Jul;61:692-711
Bioactive materials 2026 Jul;61:692-711
ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucleus pulposus cells.
Chen S, Jia S, Fan X, Zhu L, Qi B, Yan F, Gao X, Zhang L, Gao S, Shao J, Yang T, Li S, Chen G, Xiong H, Li Z, Hao Y, Meng C
Bioactive materials 2026 Jul;61:534-554
Bioactive materials 2026 Jul;61:534-554
NRF2/SLC7A11 axis-mediated metabolic reprogramming drives Benzo[a]pyrene-induced malignant transformation: Evidence from lung organoid and 16HBE cell models.
Wang Y, Kong H, Zhang Y, Su J, Wei J, Guo Y, Yu X, Nie J, Yang J
Free radical biology & medicine 2026 Jul;250:321-333
Free radical biology & medicine 2026 Jul;250:321-333
Dimethyl fumarate alleviates oxidative stress and inflammation in noise-induced hearing loss by activating Nrf2/HO-1 signaling in cochlear hair cells.
Li M, Zhang W, Huang X, Fu M, Zhang J, Chen J, Pang J, Yang H
International immunopharmacology 2026 Jul 1;180:116675
International immunopharmacology 2026 Jul 1;180:116675
Resistance exercise alleviates skeletal muscle atrophy through reduction of oxidative stress via Sestrin1 in C57BL/6J mice.
Yang X, Peng J, Huang Y, Liu S, Niu Y, Fu L
Sports medicine and health science 2026 Jan;8(1):50-60
Sports medicine and health science 2026 Jan;8(1):50-60
Adaptive bilirubin nanoscavenger alleviates pulmonary oxidative stress and inflammation for acute lung injury therapy.
Kou L, Xu Y, Li S, He Z, Huang D, Ye Z, Zhu Y, Wang Y, Di X, Yan Y, Lin Y, Zhu W, Shi X, Zhang H, Chen R
Journal of advanced research 2026 Jan;79:863-878
Journal of advanced research 2026 Jan;79:863-878
Astrocyte-Specific Nrf2 Expression Transforms Neurotoxic Reactive Astrocytes to Neuroprotective Phenotype in 3xTg-AD Mice.
Guo S, Wei F, Sun H, Jin H, Cheng W, Fu C, Wang H, Yin Y
Glia 2026 Jan;74(1):e70087
Glia 2026 Jan;74(1):e70087
Lymph node environment drives FSP1 targetability in metastasizing melanoma.
Palma M, Chaufan M, Breuer CB, Müller S, Sabatier M, Fraser CS, Szylo KJ, Yavari M, Carmona A, Kaur M, Melo LMN, Cansiz F, Monge-Lorenzo J, Flores M, Mishima E, Nakamura T, Proneth B, Labrado M, Liang Y, Cayting N, Zheng L, Cañeque T, Colombeau L, Wahida A, Friedmann Angeli JP, Tasdogan A, Hui S, Rodriguez R, Conrad M, Reticker-Flynn NE, Ubellacker JM
Nature 2026 Jan;649(8096):477-486
Nature 2026 Jan;649(8096):477-486
Punicalagin Ameliorates Diabetic Cognitive Dysfunction by Inhibiting Neuroinflammation via the CX3CL1/CX3CR1 Axis.
Zhang R, Tan X, Zhang Y, Ma Y, You Z, Huang Y, Yang L
Phytotherapy research : PTR 2026 Jan;40(1):334-350
Phytotherapy research : PTR 2026 Jan;40(1):334-350
Ononin induces ferroptosis in colorectal cancer cells via the PI3K/AKT/Nrf2 pathway to enhance anti-cancer immunotherapy.
Gui Y, Deng S, Li J, Zuo D, Fan H
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):421-439
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):421-439
Transdermal delivery of salvianolic acid B using thermosensitive hydrogel for the treatment of skin photoaging.
Wu L, Tao Y, Xu Y, Liang Z, Zhao Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):113-127
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):113-127
Kaempferol Mitigates CSE-Induced Lung Injury and Epithelial Cell Ferroptosis via Modulating Nrf2/NCOA4/GPx4 Axis.
Jin F, Xing Y, Li S, Yi Z, Wu A, Li X
Journal of cellular and molecular medicine 2026 Jan;30(1):e71010
Journal of cellular and molecular medicine 2026 Jan;30(1):e71010
Ammonium tetrathiomolybdate ameliorates heat stroke-induced murine liver injury by activating the Nrf2/HO-1 signaling pathway and inhibiting oxidative stress.
Jiang GL, Long LZ, Zhang XY, Yao TT, Cheng XY, Yu P, Zou LJ, He YJ, Jiang M, Meng J
Free radical biology & medicine 2026 Jan;242:535-548
Free radical biology & medicine 2026 Jan;242:535-548
Eugenol attenuates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the Nrf2/GPX4 pathway.
Sun S, Lu X, Yang S, Liang H, Lyu G, Chen Y, Yu L, Gao Z, Wang J, Xiao P, Jin L, Huang C, Wang X
Free radical biology & medicine 2026 Jan;242:508-520
Free radical biology & medicine 2026 Jan;242:508-520
7,8-Dihydroxyflavone protects acetaminophen induced liver injury through activating PI3K/Akt/NRF2/GPX4 mediated ferroptosis suppression.
Pei X, Mu R, Liu S, Xiong L, Wang X, Yao Q, Qi H, Li H
Free radical biology & medicine 2026 Jan;242:275-287
Free radical biology & medicine 2026 Jan;242:275-287
SS-31 improves post-cardiac arrest brain injury by inhibiting microglial ferroptosis and polarization.
Jiang T, Zhang H, Sun Y, Ji X, Xue L, Pan C, Guo Y, Xu F
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2026 Jan;23(1):e00772
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2026 Jan;23(1):e00772
Exploring the Active Substances and Mechanism of Physalis Calyx seu Fructus Against Inflammation-related Respiratory Diseases via Integrating Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry, Network Pharmacological Analysis, and Experimental Verification.
Meng H, Xu LT, Li PP, Guo DX, Li GH, Gu HR, Wang XN, Lin YQ, Xu ZP, Shen T
Chemistry & biodiversity 2026 Jan;23(1):e00496
Chemistry & biodiversity 2026 Jan;23(1):e00496
Lipocalin-2 induces macrophage/microglia pro-inflammatory phenotype after intracerebral hemorrhage via Nrf2 signaling inhibition in young and aged mice.
Zhang T, Wang C, Li Y, Fei X, Dou Y, Liu J, Wang J, Zhang D, Jiang L, Zhao L, Wei J, Hou L
Neuroscience research 2026 Jan;222:104988
Neuroscience research 2026 Jan;222:104988
PIM1 protects pancreatic ductal cancer cells from glucose deprivation-induced oxidative stress via OXR1 phosphorylation.
Wang J, Yu W, Cai S, Wei H, Peng B, Qian J, Chen Y, Zheng F, Jiang H, Xie Q, Zhou H, Fang H, Lyu J
Biochimica et biophysica acta. Molecular basis of disease 2026 Jan;1872(1):168031
Biochimica et biophysica acta. Molecular basis of disease 2026 Jan;1872(1):168031
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Li M, Peng Y, Xiao Q, Chen S, Zhang C, Chen H, Zhao Y, Chang S, Qiu L, Zhang L, Guo X, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.
Gao X, Zhang J, Lin Y, Tian K, Tu J, Wu Z, Lv X, Hu H, Liu X, Lin S, Zhu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Qin L, Zhao B, Xiong Y, Chen L, Qi S, Ma Y, Zeng H, Song Y, Liu W, Tian T, Ge G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Nobiletin Ameliorates Skeletal Muscle Performance in D-Galactose-Induced Aging Mice by Boosting Aerobic Metabolism.
Wang H, Zhang Y, Zhang Y, Wang X, Li Y, Ren F, Sun Y
Food science & nutrition 2026 Jan;14(1):e71416
Food science & nutrition 2026 Jan;14(1):e71416
A proteomics-based study on the mechanisms of Terminalia chebula Retz processed Aconitum kusnezoffii Reichb against rheumatoid arthritis and its cardiotoxicity reduction.
Wang JH, Liu YL, Zhang CC, Song L, Mei L, Sa RN, Gao Y, Tu Y
Chinese medicine 2026 Jan 9;21(1):21
Chinese medicine 2026 Jan 9;21(1):21
Exosomes derived from ADSC suppress endothelial cells ferroptosis and alleviate sepsis acute liver injury via regulation of Keap1/Nrf2/GPX4 axis.
Wang X, Wu D, Liu X, Xu Y, Wang P, Fu H, Ma Y, Liu S, Wang Q, Xu XJ, Dai Z, Zhang Q, Yin W, Shen K, Li J
Stem cells (Dayton, Ohio) 2026 Jan 8;44(1)
Stem cells (Dayton, Ohio) 2026 Jan 8;44(1)
RVG-targeted extracellular vesicles loaded with echinatin attenuate dopaminergic neurodegeneration via the IGF-2/PI3K/Akt pathway in Parkinson's disease mice.
Ding L, Xiao Y, Xu Z, Zhu Z, Gan T, Huang X, Shu H, Liang X, Mo M, Huang X, Zhu X, Huang W, Xu P, Zhang W
Journal of nanobiotechnology 2026 Jan 7;24(1):117
Journal of nanobiotechnology 2026 Jan 7;24(1):117
Methotrexate-triggered ferroptosis suppresses oral cancer progression by phosphorylated KEAP1-mediated NRF2 degradation to inhibit SLC7A11/GPX4 signaling pathway.
Yu C, Zhang T, Yuan J, Su Y, Zhang H, Xu L, Li X, Cui J, Xu R, Zhou Y, Huang H, Zhou X, Zhou Y, Zhang E
Cancer cell international 2026 Jan 6;26(1):64
Cancer cell international 2026 Jan 6;26(1):64
Effects of Blue Light Exposure on Hepatic Inflammation and Gut Microbiota in Mice Consuming a High-Fat, High-Fructose Diet.
Huang WC, Lee PN, Yeh WJ, Wu WC, Shih HY, Chen YJ, Yang HY
Nutrients 2026 Jan 4;18(1)
Nutrients 2026 Jan 4;18(1)
Low-Intensity pulsed ultrasound reduces ovarian cryopreservation injury through the Notch signaling pathway.
Zhu F, Zhang Y, He F, Liu Z, Zhang H, Duan C, Duan Y, Zhu Y, Zhang C, Zhou Y
Reproductive biology and endocrinology : RB&E 2026 Jan 28;24(1)
Reproductive biology and endocrinology : RB&E 2026 Jan 28;24(1)
α-Lipoic Acid Alleviates Non-Alcoholic Fatty Liver Disease by Elevating Chaperone-Mediated Autophagy and Increasing β-Oxidation via AMPK-TFEB Axis.
Dong K, Zhang M, Xu J, Bai X, Yang J
Nutrients 2026 Jan 26;18(3)
Nutrients 2026 Jan 26;18(3)
The PI3K/AKT/NRF2 Signaling Pathway Involved in the Improvement of CUMS-Induced Depressive-like Behaviors by Apigenin.
Wu L, Ge H, Li C, Huang J, Sun L, Xie Y, Xiao L, Wang G
Pharmaceuticals (Basel, Switzerland) 2026 Jan 23;19(2)
Pharmaceuticals (Basel, Switzerland) 2026 Jan 23;19(2)
Human amniotic mesenchymal stem cell-derived extracellular vesicles improve oocyte quality and embryonic development by increasing antioxidant capacity in aged mice.
La B, Jiang C, He J, Ni M, Zhou J, Wu H, Ning S, Dai W, Yan Z, Cui Y, Qin L, Liu J
Journal of ovarian research 2026 Jan 2;19(1):41
Journal of ovarian research 2026 Jan 2;19(1):41
PKM2 preconditioning protects endothelial cells from pyroptosis and BBB disruption via NRF2/TRX/TXNIP signaling in neonatal hypoxic-ischemic brain injury.
Hu Y, Yu G, Lu L, Nan Y, Wang X, Feng Y, Zhu J, Wang X, Lin Z
Journal of neuroinflammation 2026 Jan 13;23(1):57
Journal of neuroinflammation 2026 Jan 13;23(1):57
Repositioning of Alogliptin to Mitigate Secondary Injury Induced by Repetitive TBI: Potential Role of its Antioxidant and Anti- Inflammatory Effects.
Raslan HA, Michel HE, Menze ET, El-Gazar AA
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2026 Jan 13;21(1):6
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2026 Jan 13;21(1):6
Celastrol mitigates diabetic kidney disease by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 pathway.
Tang YW, Xu TJ, Cao JW, Jiang MY, Yang RC, Wan F
Diabetology & metabolic syndrome 2026 Jan 13;18(1):55
Diabetology & metabolic syndrome 2026 Jan 13;18(1):55
Dunaliella salina-Loaded Diosmetin Carriers Alleviate Oxidative Stress and Inflammation in Cisplatin-Induced Acute Kidney Injury via PI3K/AKT Pathway.
Huangfu Y, Chen W, Guo D, Wang P, Li A, Yang Y, Li S, Wang Q, Wang B, Feng S
Pharmaceutics 2026 Jan 12;18(1)
Pharmaceutics 2026 Jan 12;18(1)
Detection of factors related to ROS and ERS in the reproductive organs of hibernating Daurian ground squirrels (Spermophilus dauricus)†.
Wang MD, Dong JY, Chen L, Li LF, Xi YF, Wang JC, Hu LJ, Xu JH, Wang Z
Biology of reproduction 2026 Jan 11;114(1):310-324
Biology of reproduction 2026 Jan 11;114(1):310-324
YangXue QingNao Wan ameliorates vascular dementia in 2-VO rats via inhibition of ferroptosis.
Zhang YJ, Liang HB, Wang XY, Chen FK, Guo S, Yang C, Li AQ, Jiao YQ, Yan L, Pan CS, Huo XM, Sun K, Ma ZZ, Han JY, Liu J
Journal of ethnopharmacology 2026 Jan 10;354:120550
Journal of ethnopharmacology 2026 Jan 10;354:120550
Explore the chemical components of Angong Niuhuang Pill and its potential mechanisms for fever treatment based on UHPLC-Q-Exactive orbitrap HRMS, transcriptomics, and experiment verification.
Gao F, An J, Jia S, Zhu Z, Zhang Z, Li Y, Jiao J, Li S, Liu Y, Yin H, Xu B, Lei H
Journal of ethnopharmacology 2026 Jan 10;354:120542
Journal of ethnopharmacology 2026 Jan 10;354:120542
Coptisine mitigates acute lung injury by alleviating ferroptosis through the PI3K/AKT/Nrf2 pathway.
Zhou L, Xu H, Lei X, Yu H, Xia L, Liu X, He J, Lin P, Zhou Y, Chen C, Li Y
Journal of ethnopharmacology 2026 Jan 10;354:120472
Journal of ethnopharmacology 2026 Jan 10;354:120472
Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration.
Huang X, Zhang Y, Jiang Y, Li T, Yang S, Wang Y, Yu B, Zhou M, Zhang G, Zhao X, Sun J, Sun X
Neural regeneration research 2026 Jan 1;21(1):406-416
Neural regeneration research 2026 Jan 1;21(1):406-416
Theacrine protects vascular endothelial cells against oxidative damage after ischemic stroke by inhibiting Rac1 and activating Nrf2 pathway.
Zhang Y, Li Y, Li X, Liao P, Chen W, Feng Y, Zhang X, Chen Y, Nan L, Li H, Yan G
International immunopharmacology 2026 Jan 1;168(Pt 2):115951
International immunopharmacology 2026 Jan 1;168(Pt 2):115951
Carnosic acid attenuates ventilator-induced diaphragmatic dysfunction via activation of the Nrf2/HO-1 pathway.
Liu Z, Yu Q, Zhou X, Ma H, Wei R, Xia J
International immunopharmacology 2026 Jan 1;168(Pt 2):115926
International immunopharmacology 2026 Jan 1;168(Pt 2):115926
Lycium barbarum polysaccharide LBP3 alleviates 5-Fluorouracil-induced intestinal injury via a mechanism associated with activating Nrf2 and improving mitochondrial function.
Xie X, Cai Y, Xu R, Yang C, Li P, Zhu Y, Luo X, Zhou L, Wang Q
International immunopharmacology 2026 Jan 1;168(Pt 2):115879
International immunopharmacology 2026 Jan 1;168(Pt 2):115879
Forsythoside B protects cartilage and subchondral bone in osteoarthritis by regulating the Nrf2/NF - κ B signaling pathway.
Zhang H, He Z, Wang H, Lu F, Chen H
International immunopharmacology 2026 Jan 1;168(Pt 1):115762
International immunopharmacology 2026 Jan 1;168(Pt 1):115762
Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer.
Mei J, Tian HX, Zhang XY, Chen YS, Wang LY, Zhang Z, Zhang YL, Rong DC, Zeng J, Dong M, Gao Y, Yin JY, Wu HJ, Wang PY, Zhang W
Journal of advanced research 2026 Feb;80:1121-1137
Journal of advanced research 2026 Feb;80:1121-1137
FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages.
Bai L, Xiong J, Chen S, Hu J, Zhang M, Li B, Hu J, He M
International journal of molecular medicine 2026 Feb;57(2)
International journal of molecular medicine 2026 Feb;57(2)
Gastrodin alleviates alcohol-induced developmental and neurotoxic effects in zebrafish larvae by suppressing ferroptosis via regulating the Nrf2/GPX4 signaling pathway.
Li R, Yang W, Zheng L, Yan X, Liu C, Zhang Y, Li J
Toxicology and applied pharmacology 2026 Feb;507:117684
Toxicology and applied pharmacology 2026 Feb;507:117684
Dose-Dependent Ferroptosis Induction in Osteosarcoma via NRF2/GPX4 Axis Modulation by Plasma-Activated Liquid Therapy.
Xiao L, Zhang M, He P, Wang H, Li S, Wu Y, Xu S, Hu Y
Antioxidants & redox signaling 2026 Feb;44(7-9):292-310
Antioxidants & redox signaling 2026 Feb;44(7-9):292-310
Ezetimibe attenuates diabetic retinopathy via NRF2-mediated suppression of inflammation and oxidative stress.
Cheng L, Cheng S, Zhu R, Xu G
Journal of diabetes and its complications 2026 Feb;40(2):109250
Journal of diabetes and its complications 2026 Feb;40(2):109250
A multi-omics approach reveals PFHxS as an environmental driver of gastric cancer via KEAP1 downregulation.
Teng Q, Xu K, Yang X, Wang X, Chen W, Li Y
Ecotoxicology and environmental safety 2026 Feb;311:119902
Ecotoxicology and environmental safety 2026 Feb;311:119902
Dose-Dependent Biphasic Effect of Palmitic Acid on Oligodendrocyte Function: Impacts on Viability, Differentiation, and Myelination.
Palmiero A, Pipicelli L, Rosa G, Sozio C, Punziano C, Raia M, Faraonio R, Vitolo G, Cammarota M, Boscia F, Menale C, Santillo M, Damiano S
Journal of cellular physiology 2026 Feb;241(2):e70145
Journal of cellular physiology 2026 Feb;241(2):e70145
Apigenin alleviates DFZ-induced cardiac, renal, and intestinal injury in carp by modulating oxidative stress and inflammatory responses.
Guan T, Zhou W, Gao Y, Dong Q, Jin X, Li Y, Xu Z, Yu H, Dong J
Fish & shellfish immunology 2026 Feb;169:111054
Fish & shellfish immunology 2026 Feb;169:111054
Melatonin counteracts Iodoacetic acid induced ferroptosis by regulating Nrf2 in porcine oocytes.
Lu QY, Zhan CL, Lee SH, Li XH, Kim JD, Lee GH, Sim JM, Song HJ, Jin YY, Cui XS
Cellular signalling 2026 Feb;138:112257
Cellular signalling 2026 Feb;138:112257
Idebenone alleviates rotenone-induced mitochondrial dysfunction through mitophagy and mitochondrial biogenesis in muscle cells.
Zhang C, Li M, Meng L, Xia W, Wu G
Cellular signalling 2026 Feb;138:112221
Cellular signalling 2026 Feb;138:112221
FSHR-targeting tetrahedral DNA frameworks ameliorate ovarian aging through oxidative stress elimination.
Dai Y, Guo Y, Chen D, Li P, Xue L, Feng Y, Tang W, Wu C, Wei S, Dai J, Jiang D, Wang S, Wu M
Journal of nanobiotechnology 2026 Feb 7;24(1)
Journal of nanobiotechnology 2026 Feb 7;24(1)
Mangosteen (Garcinia mangostana) Pericarp and Leaf Tinctures Inhibit LPS-Induced Pro-Inflammatory Responses in Macrophages and Activate Nrf2.
Tocmo R, Nauman MC, Huang Y, Subedi P, Johnson JJ
Nutrients 2026 Feb 5;18(3)
Nutrients 2026 Feb 5;18(3)
VAMP7 governs ferroptosis suppression and cisplatin resistance in esophageal cancer: a dual-targeting therapeutic paradigm.
Zhu J, Xie M, Dai L, Yang Z, Xue W, Jiang Z, Zhou J
Cancer cell international 2026 Feb 3;26(1)
Cancer cell international 2026 Feb 3;26(1)
The dual functions of a nor-sesquiterpene-triazole derivative against influenza A viruses through the activation of the Nrf2/HO-1 signaling pathway and interaction with hemagglutinin.
Zhou S, Wei J, Li S, Qiu J, Ma S, He J
RSC medicinal chemistry 2026 Feb 27;17(3):1735-48
RSC medicinal chemistry 2026 Feb 27;17(3):1735-48
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
Zhang H, Zhang D, Wang Z, Liu K, Xu C, Sun H, Yan Z, Li C, Lu B, Yin Y, Zhao C, Niu Y, Li W
Biology direct 2026 Feb 26;21(1)
Biology direct 2026 Feb 26;21(1)
Pramipexole alleviates ferroptosis in HT22 cells induced by oxygen-glucose deprivation/reoxygenation via the Nrf2/SLC7A11/GPX4 pathway.
Zhang L, Kang X, Wang Q, Cao Z, Gao R, Yu Y, Li T, Liu L
Scientific reports 2026 Feb 26;16(1)
Scientific reports 2026 Feb 26;16(1)
Selenoprotein thioredoxin reductase 1 promotes cancer cells ferroptosis by suppressing GPX4 expression.
Luan J, He J, Wu D, Duan Y, Hou G, Ma S, Qin J, Sun N, He Y, Zhang W, Gao M
Cell death and differentiation 2026 Feb 26;
Cell death and differentiation 2026 Feb 26;
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells.
Zheng X, Huang R, Liu Z, Liu T, Lin H, Yin L, Wu Q, Zhao M
Bioengineering (Basel, Switzerland) 2026 Feb 24;13(3)
Bioengineering (Basel, Switzerland) 2026 Feb 24;13(3)
N-Salicyloyl Tryptamine Derivatives Improve Mitochondrial Function To Treat Alzheimer's Disease.
Zeng J, Zhao Y, Chen Y, Wu K, Yang C, Wu Y, Pang G, Zhang M, Wen H, Wang Z, Peng X
ACS omega 2026 Feb 24;11(7):12479-12493
ACS omega 2026 Feb 24;11(7):12479-12493
Targeting mitochondrial phosphatase PGAM5 alleviates ferroptosis and acute pancreatitis by upregulating NRF2-mediated FSP1 expression.
Ma S, Qin J, Luan J, Hou G, He J, Gao M
Cell death & disease 2026 Feb 21;17(1)
Cell death & disease 2026 Feb 21;17(1)
Pterostilbene Promotes Spinal Cord Injury Recovery by Inhibiting Ferroptosis via Keap1/Nrf2/SLC7A11/GPX4 Axis Activation.
Dong Y, Liu Y, Ji Y, Meng W, Cheng X, Zheng X
Antioxidants (Basel, Switzerland) 2026 Feb 2;15(2)
Antioxidants (Basel, Switzerland) 2026 Feb 2;15(2)
Targeting oxidative stress and mitochondrial dysfunction via URG7 overexpression in an in vitro Parkinson's disease neuronal model.
Nigro I, Miglionico R, Lela L, Milella L, Bisaccia F, Armentano MF
Scientific reports 2026 Feb 19;16(1)
Scientific reports 2026 Feb 19;16(1)
SREBP1 knockdown triggers ferroptosis by suppressing the Nrf2-XCT/GPX4 axis in ovarian cancer.
Nie R, Zhou H, Chen L, Quan H, Zhang Y, Lin Z
Cell death discovery 2026 Feb 18;12(1)
Cell death discovery 2026 Feb 18;12(1)
Diosmetin, an active ingredient of Schizonepeta tenuifolia, alleviates acne by regulating inflammation and oxidative stress.
Pan Y, Sun R, Thomas ER, Pan S, Yang L, Wang W, Chen L, Li X
Naunyn-Schmiedeberg's archives of pharmacology 2026 Feb 18;
Naunyn-Schmiedeberg's archives of pharmacology 2026 Feb 18;
The role of glutamine/Nrf2-enhanced PHGDH in Cadmium-induced lactate utilization.
Pang Y, Li S, Zhang Q, Liu Y, Kong Y, Cao J
Free radical biology & medicine 2026 Feb 16;244:296-311
Free radical biology & medicine 2026 Feb 16;244:296-311
Fusobacterium nucleatum drives endothelial cell senescence by disrupting NOX4/NRF2 balance.
Wu P, Zhou J, Wang J, Wu Y, Wang H, Zhao L
mBio 2026 Feb 11;17(2):e0344125
mBio 2026 Feb 11;17(2):e0344125
Inhibition of MAGL ameliorates glucocorticoid-induced bone loss by regulating the Nrf2 signaling.
Huang C, Wang X, Liu S, Xiao P, Lu Z, Xu Y, Tian Y
Free radical biology & medicine 2026 Feb 1;243:67-81
Free radical biology & medicine 2026 Feb 1;243:67-81
Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis.
Gong D, Chen X, Dong Z, Chen H, Liu Z
Renal failure 2026 Dec;48(1):2652103
Renal failure 2026 Dec;48(1):2652103
Fisetin alleviates lipopolysaccharide-induced mastitis by inhibiting ferroptosis and modulating the gut microbiota.
Tong C, Wang L, Wen H, Yao X, Tong J, Zhang R, Li X, Xiang Y, Wang X
The veterinary quarterly 2026 Dec;46(1):2642789
The veterinary quarterly 2026 Dec;46(1):2642789
Discovery of ferulic acid carbamate derivatives as dual-targeting agents of BuChE and Nrf2 for Alzheimer's disease.
Lao K, Li Y, Xiao Y, Sun Y, Dai Y, Li H, Yang Y, Zhang Y, Wang J, Li W, Gou X, Guan L
Journal of enzyme inhibition and medicinal chemistry 2026 Dec;41(1):2645483
Journal of enzyme inhibition and medicinal chemistry 2026 Dec;41(1):2645483
Resveratrol Attenuates Neuroinflammation and Myelination Deficits in Repeated Sevoflurane-Exposed Neonatal Mice.
Che J, Wu Y, Dong J, Shi C, Chen Y, He Z, Zhang X, Zhang J
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2026 Apr;86(2):e70123
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2026 Apr;86(2):e70123
Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1.
Xu LT, Han QT, Xu ZP, Wang XN, Zhang H, Shen T
Journal of advanced research 2026 Apr;82:1149-1162
Journal of advanced research 2026 Apr;82:1149-1162
OSBPL3 promotes LUAD metastasis and glycolysis through transcriptional upregulation of PLAU via NFE2L2.
Zhang Q, Zhang J, Li J, Chen S, Liu Y, Li K, Guo M
Translational oncology 2026 Apr;66:102693
Translational oncology 2026 Apr;66:102693
Ultrasound-activated piezoelectric Silk-PVDF hydrogel reprograms the osteoimmune microenvironment via NRF2 signaling for accelerated bone regeneration.
Mo G, Qing L, Zhang C, Huang L, Yan H, Lu S, Zhang Y, Chen W, Xiang X, Wang N, Han G, Li Y, Jiang L, Zhang J
Materials today. Bio 2026 Apr;37:102779
Materials today. Bio 2026 Apr;37:102779
NRF2-TERT-ACSL4 pathway inhibits ferroptosis and regulates cytoskeletal dynamics to mitigate ovarian aging.
Chen Y, Zhang J, Cui S, Zhang W, Xu C, Cheng H, Zhang L, Liu Y, Zhang X, Yin Z, Cao Y, Liang D, Yu B
International journal of biological macromolecules 2026 Apr;357:151325
International journal of biological macromolecules 2026 Apr;357:151325
Puerarin attenuates myocardial ischemia‑reperfusion injury by inhibiting myocardium pyroptosis via the NRF2/HO‑1 signaling pathway.
Zheng X, Li J, Hu T, Tan L, Lan D, Deng Y
Molecular medicine reports 2026 Apr;33(4)
Molecular medicine reports 2026 Apr;33(4)
Nutritional activation of the Nrf2-Pth1r axis by pyrroloquinoline quinone enhances peak bone mass and potentiates teriparatide in osteoporosis.
Xue Q, Gu Y, Li J, Qin R, Li M, Li Y, Chen Z, Li C, Zhang J, Yang R
Free radical biology & medicine 2026 Apr;247:393-406
Free radical biology & medicine 2026 Apr;247:393-406
Epigallocatechin gallate ameliorates brain injuries after intracerebral hemorrhage by inhibiting ferroptosis through upregulation of Nrf2-Keap1 pathway.
Zhou SY, Guo ZN, Sun YY, Jia WB, Zhu HJ, Liu J, Qu Y, Jin H
Brain research bulletin 2026 Apr;237:111812
Brain research bulletin 2026 Apr;237:111812
Ferulic acid activates Nrf2/HO-1 signaling axis to ameliorate neuronal Golgi stress by SKP2.
Dong Q, Liu C, Li A, Zhao X, Qin X, Xu W, Tang G
Journal of pharmacological sciences 2026 Apr;160(4):209-220
Journal of pharmacological sciences 2026 Apr;160(4):209-220
The ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis.
Lv X, He Z, Xue J, Yang Y, Tang Y, Cai H, Luo H, Li X, Dong Z, Liu Y, Zeng J, Yang Z, Cheng P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157999
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157999
Pyrroloquinoline quinone alleviates age-related osteoarthritis via nuclear factor erythroid 2-related factor 2-mediated stress response and insulin-like growth factor 1 receptor upregulation.
Xue Q, Gu Y, Qin R, Chen Z, Li J, Li M, Li Y, Li C, Gao W, Liu B, Yang R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157996
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157996
Lactate modulates microglial M2 polarization via H3K9 lactylation in ischemic stroke.
Li B, Xu K, Yu J
Journal of translational internal medicine 2026 Apr;14(2):276-293
Journal of translational internal medicine 2026 Apr;14(2):276-293
Engineered Mesenchymal Stem Cells with Endogenous Trehalose Expression Activate the NRF2-HMOX1 Pathway to Enhance Antioxidant Stress and Wound Healing Capacity.
Wang Z, Liu X, Chen X, Jing J, Chen Q, Zhou F, Chen Z, Fang W, Wang L, Wang Y, Li Z, Wang Q, Gao J, Zhao J, Xu G, Pang R
Advances in wound care 2026 Apr 8;:21621918261438590
Advances in wound care 2026 Apr 8;:21621918261438590
Targeting SAT1 alleviates high glucose-induced tubular ferroptosis and fibrosis: implications for diabetic kidney disease.
Tang Y, Wang S, Wang Y, Zhang T, Liu Y, Di Y
Histochemistry and cell biology 2026 Apr 5;164(1)
Histochemistry and cell biology 2026 Apr 5;164(1)
Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis.
Wang Y, Xu L, Pan C, Cao R, Zeng P, Lyu X, Hu Q, Yan Z, Huang S, Dang N
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 3;:e23189
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 3;:e23189
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains.
Sahu AK, Minetti A, Di Fraia D, Marino A, Winterhalter PR, Giustarini D, Rossi R, Simm A, Neri F, Galvagni F, Gerhardt C, Pfirrmann T, Ori A
Nature communications 2026 Apr 21;17(1)
Nature communications 2026 Apr 21;17(1)
The curcumin derivative DMC-GF promotes ferroptosis through the Nrf2/HMOX1 pathway, increasing glioma susceptibility to temozolomide.
Tao H, Li X, Han Z, Wang Z
Scientific reports 2026 Apr 18;
Scientific reports 2026 Apr 18;
Discovery of novel Keap1-targeting hydrophobic tag (HyT) tethering degraders with potent Nrf2 activation activity.
Li Z, Liu M, Zhao H, Zhang W, Wang L, Zhang Y, Xu J, Shen T, Ren D, Wang X
European journal of medicinal chemistry 2026 Apr 15;308:118700
European journal of medicinal chemistry 2026 Apr 15;308:118700
Notopterol attenuates atherosclerosis by promoting macrophage cholesterol efflux via targeting KEAP1/NRF2 interaction.
Qin Y, Meng J, Chen Y, Zhang W, Yi J, Wang S
International immunopharmacology 2026 Apr 15;175:116404
International immunopharmacology 2026 Apr 15;175:116404
Baicalein alleviates Western diet-induced obesity via metabolically activated adipose tissue macrophages by inducing Nrf2.
Zhang S, Yang S, Kong B, Zhang Q, Zhou Z, Zhao W, Wang J, Tang Y, Yao P
The Journal of nutritional biochemistry 2026 Apr 15;155:110381
The Journal of nutritional biochemistry 2026 Apr 15;155:110381
Peroxisome-derived and liver-specific hydroxyacid oxidase 1-mediated hydrogen peroxide promotes ferroptosis by augmenting peroxisomal ROS.
Peng X, Zhou Y, Chen J, Wang Z, Peng X, Wang H, Shu L, Liu N, Long Y, Linghu L, Zhang Z, Peng Y, Zhao Y, Xiao D, Shi Y, Liu S, Tao Y
Journal of advanced research 2026 Apr 15;
Journal of advanced research 2026 Apr 15;
Targeting CXCL16-expressing macrophages with a biomimetic nanocarrier system attenuates cartilage degeneration in osteoarthritis.
Yang Q, Xu Y, Zhan Y, Li J, Peng R, Yu B, Zhang L, Liang G, Deng P, Cao H, Han Y, Huang Z, Pan J, Jiang T, Yang W, Feng Y, Huang X, Wu S, Gui T, Ye Y
Journal of controlled release : official journal of the Controlled Release Society 2026 Apr 10;392:114734
Journal of controlled release : official journal of the Controlled Release Society 2026 Apr 10;392:114734
Moxibustion delays ovarian aging by regulating mitochondrial biogenesis and improving oocyte quality.
Yin Y, Xu Y, Li Z, Chen M, Song Z, Li H, Lu G, Shen M
Chinese medicine 2026 Apr 10;21(1)
Chinese medicine 2026 Apr 10;21(1)
α-Lipoic Acid Activates the Nrf2/HO-1 Pathway to Ameliorate Arsenic-Induced Multiorgan Oxidative Damage.
Qin C, Yang X, Chen M, Lei L, Cai L, Wang Y, Li H, Yang Z, Wei Z, Zhou Z, Wang C, Liang B
Journal of agricultural and food chemistry 2026 Apr 1;74(12):10177-10193
Journal of agricultural and food chemistry 2026 Apr 1;74(12):10177-10193
Chronic Psychological Stress Activates TRP/TAM/CXCL1 Signaling to Promote Breast Cancer Adipocyte Lipolysis via KEAP1 m(6)A Demethylation.
Zhan D, She Y, Zhang X, Zhang J, Wang S, Hong S, Zheng Y, Wang N, Wang Z
Research (Washington, D.C.) 2025;8:0980
Research (Washington, D.C.) 2025;8:0980
EDEM1 Inhibits Endoplasmic Reticulum Stress to Induce Doxorubicin Resistance through Accelerating ERAD and Activating Keap1/Nrf2 Antioxidant Pathway in Triple-Negative Breast Cancer.
Wang Y, Liang Y, Luo D, Ye F, Jin Y, Wang L, Li Y, Han D, Wang Z, Chen B, Zhao W, Wang L, Yang Q
Research (Washington, D.C.) 2025;8:0797
Research (Washington, D.C.) 2025;8:0797
Astaxanthin ameliorates allergic rhinitis via suppression of the HMGB1/TLR4 signaling pathway.
Lei X, Pan J, Deng K
Central-European journal of immunology 2025;50(3):276-289
Central-European journal of immunology 2025;50(3):276-289
Green coffee bean extract rich in chlorogenic acids prevents muscle capillary regression via inhibiting oxidative stress and enhancing angiogenesis.
Xing J, Lin H, Nakanishi R, Iwai K, Maeshige N, Kondo H, Fujino H
Biomedical research (Tokyo, Japan) 2025;46(1):15-25
Biomedical research (Tokyo, Japan) 2025;46(1):15-25
Targeting Reactive Oxygen Species and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots.
Zhong C, Song N, Huang P, Han L, Zhang J, Lu Z, Wang L
Biomaterials research 2025;29:0249
Biomaterials research 2025;29:0249
Sulforaphane alleviates membranous nephropathy by inhibiting oxidative stress-associated podocyte pyroptosis.
Lv D, Chu L, Du Y, Li C, Bao N, Su Y, Wang G, Zheng Y, Yu Y
Iranian journal of basic medical sciences 2025;28(2):237-244
Iranian journal of basic medical sciences 2025;28(2):237-244
Metformin Alleviates Liver Metabolic Dysfunction in Polycystic Ovary Syndrome by Activating the Ethe1/Keap1/PINK1 Pathway.
Xie Y, Tian Y, Huang J, Deng W, Li X, Liu Y, Liu H, Gao L, Xie Q, Yu Q
International journal of biological sciences 2025;21(8):3505-3526
International journal of biological sciences 2025;21(8):3505-3526
Macrophage KDM2A promotes atherosclerosis via regulating FYN and inducing inflammatory response.
Xue Y, Peng Y, Jin L, Liu L, Liu Q, Yuan X, Wang J, Zhao M, Zhang W, Luo S, Li Y, Luo M, Huang L
International journal of biological sciences 2025;21(6):2780-2805
International journal of biological sciences 2025;21(6):2780-2805
TRIM32 promotes neuronal ferroptosis by enhancing K63-linked ubiquitination and subsequent p62-selective autophagic degradation of GPX4.
Zhou X, Zhao Y, Huang S, Shu H, Zhang Y, Yang H, Ren Y, Zhou X, Liu W, Song T, Zhao J, Ma J
International journal of biological sciences 2025;21(3):1259-1274
International journal of biological sciences 2025;21(3):1259-1274
Tetramethylpyrazine attenuates sodium arsenite-induced acute kidney injury by improving the autophagic flux blockade via a YAP1-Nrf2-p62-dependent mechanism.
Song Z, Hei TK, Gong X
International journal of biological sciences 2025;21(3):1158-1173
International journal of biological sciences 2025;21(3):1158-1173
Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells.
Dai X, Xu Z, Lv X, Li C, Jiang R, Wang D, Xi M, Li T
International journal of biological sciences 2025;21(2):874-892
International journal of biological sciences 2025;21(2):874-892
Imbalance of Bone Homeostasis Caused by Nrf2 Deficiency Leads to Bone Loss in OVX Rats.
Sun P, Wang Z, Chen S, Chen X, Zhou F, Zhang C, Yang J, Huang Y, Lin Y
Stem cells international 2025;2025:7214250
Stem cells international 2025;2025:7214250
Human umbilical cord mesenchymal stem cell-derived exosomes mitigate acute radiation-induced intestinal oxidative damage via the Nrf2/HO-1/NQO1 signaling pathway.
Wang H, Wang J, Yang G, Li Y, Chen W, Yu J, Han X
PloS one 2025;20(6):e0324238
PloS one 2025;20(6):e0324238
Voluntarily wheel running protects doxorubicin-induced kidney injury by inhibiting oxidative stress through mitochondrial function.
Jiang X, Wang Z, Wang L, Wang Y, Zhao L, Jiang H
PloS one 2025;20(4):e0321121
PloS one 2025;20(4):e0321121
Chlorogenic acid inhibits NLRP3 inflammasome activation through Nrf2 activation in diabetic nephropathy.
Bao L, Gong Y, Xu W, Dao J, Rao J, Yang H
PloS one 2025;20(1):e0316615
PloS one 2025;20(1):e0316615
Exosomes Derived From Human Mesenchymal Stem Cells Mitigate Follicular Interstitial Cell Ferroptosis via the miR-26a-5p/PTEN/GPX4 Axis in Rats with Chemotherapy-Induced Premature Ovarian Insufficiency.
Chen J, Huo X, Qian M, Xue Q, He Y, Xu P, Wang Y, Tang X, Luo Q, Bao H, Xiong Y
International journal of nanomedicine 2025;20:10195-10212
International journal of nanomedicine 2025;20:10195-10212
Liver-specific Bcl3 Knockout Alleviates Acetaminophen-induced Liver Injury by Activating Nrf2 Pathway in Male Mice.
Gao J, Lu W, Xin Y, Ma H, Sheng X, Gao G, Kang X, Jiang S, Zhao Y, Lv Y, Niu Y, Liang Y, Wang H
Cellular and molecular gastroenterology and hepatology 2025;19(6):101483
Cellular and molecular gastroenterology and hepatology 2025;19(6):101483
Magnesium Isoglycyrrhizinate Alleviates Alectinib-Induced Hepatotoxicity by Inhibiting Mitochondrial Damage-Mediated Pyroptosis.
Chen Y, Wang C, Wu Y, Zeng Y, Xie S, Weng J, Guo L, Fu J, Zhou T, Zhang X, Zhou Z
Drug design, development and therapy 2025;19:6219-6233
Drug design, development and therapy 2025;19:6219-6233
Vaccarin Ameliorates Renal Fibrosis by Inhibiting Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway.
Cui M, Xu Q, Duan L, Lu J, Hu J
Drug design, development and therapy 2025;19:1609-1626
Drug design, development and therapy 2025;19:1609-1626
Sakuranetin Prevents Acetaminophen-Induced Liver Injury via Nrf2-Induced Inhibition of Hepatocyte Ferroptosis.
Long Z, Yu X, Li S, Cheng N, Huo C, Zhang X, Wang S
Drug design, development and therapy 2025;19:159-171
Drug design, development and therapy 2025;19:159-171
Remimazolam Suppresses Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury by Regulating AKT/GSK-3β/NRF2 Pathway.
Duan M, Yu N, Liu J, Zhao Y, Zhang J, Song S, Wang S
Drug design, development and therapy 2025;19:111-128
Drug design, development and therapy 2025;19:111-128
Ghrelin alleviates high glucose-induced retinal microvascular endothelial cell injury by activating Nrf2/HO-1 pathway to inhibit ferroptosis.
Wang FF, Li R, Liao D, Liu CQ, Yang XL
International journal of ophthalmology 2025;18(6):978-985
International journal of ophthalmology 2025;18(6):978-985
IGF2BP1 Enhances Neprilysin mRNA Stability to Promote Proliferation, Invasion, and Angiogenesis in Placental Trophoblasts.
Fan C, Zhou H, Pan Y, Lu D
International journal of general medicine 2025;18:967-980
International journal of general medicine 2025;18:967-980
Hylotelephium mingjinianum Extract Attenuates Oxidative Stress and Inflammation in Experimental Periodontitis.
Yuan L, Kong C, Shi N, Chen J, Zhang T, Wang X
Journal of inflammation research 2025;18:8263-8276
Journal of inflammation research 2025;18:8263-8276
Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense.
Shi J, Xuan Y, Zhang Q, Chen J, Zhu W, Zhang H, Duan Y
Journal of inflammation research 2025;18:10061-10079
Journal of inflammation research 2025;18:10061-10079
Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway.
Wang Y, Ji X, Wang X, Sun M, Li C, Wu D
Journal of inflammation research 2025;18:1-15
Journal of inflammation research 2025;18:1-15
Curculigoside alleviates ferroptosis in renal interstitial fibrosis by regulating the Nrf2/HO-1 signaling pathway.
Liu T, Sui M, Yu C, Bao Y, Xing L, Hou D, Xie R
American journal of translational research 2025;17(10):7640-7658
American journal of translational research 2025;17(10):7640-7658
TYMS Enhances Colorectal Cell Antioxidant Capacity Via the KEAP1-NRF2 Pathway to Resist Ferroptosis.
Chen J, Wu W, Wang L, Zhang J, Che X, Zhai L, Zhao Z, Li Y
Journal of Cancer 2025;16(2):417-429
Journal of Cancer 2025;16(2):417-429
Adipose tissue-specific Nrf2 knockdown inhibits the cGAS-STING pathway to attenuate inflammation in obese mice.
Zhao L, Tuerxunaili L, Shi G, Wu M, Jiao Y
Frontiers in endocrinology 2025;16:1711793
Frontiers in endocrinology 2025;16:1711793
Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk.
Liang L, Nie X, Zhao N, Li M, Li M, Li Z, Wu M, Wu X, Lee CL, Shu P, Zhong J
Frontiers in pharmacology 2025;16:1686234
Frontiers in pharmacology 2025;16:1686234
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of acteoside in the treatment of diabetic nephropathy.
Luo Z, Zhang SJ, Tang JY, Deng Y, Kang Y, Zhang XH, Lu HM, Wang YX, Liu WJ, Ma Y
Frontiers in pharmacology 2025;16:1660227
Frontiers in pharmacology 2025;16:1660227
Targeted ferroptosis of myofibroblasts by tubeimoside I attenuates hypertrophic scar formation.
Wang J, Wang C, Jia Y, Chen F, Wang Y, Du J
Frontiers in pharmacology 2025;16:1654108
Frontiers in pharmacology 2025;16:1654108
Fangchinoline attenuates hepatic fibrosis by regulating taurine metabolism and oxidative stress.
Yin H, Lian H, Wang Y, Chen L, Liu X, Liu Y
Frontiers in pharmacology 2025;16:1633519
Frontiers in pharmacology 2025;16:1633519
Jianpi-Huayu-Jiedu formula improves metabolic dysfunction-associated steatohepatitis through ameliorateing hepatic oxidative stress and lipid accumulation in vivo and in vitro.
Wu X, Chen T, Zhang Z, Wang D, Zhou K, Li J, Xu L, Meng C, Pan H, Huang J, Gao Y, Li S
Frontiers in pharmacology 2025;16:1612726
Frontiers in pharmacology 2025;16:1612726
Iridoids derived from Valeriana jatamansi Jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signaling pathway.
He Y, Lu J, Pang R, Ding L, Wang Y, Xiao H, Cheng C, Luo Y, Hu X, Wang W
Frontiers in pharmacology 2025;16:1597719
Frontiers in pharmacology 2025;16:1597719
Polygala tenuifolia Willd. Extract delays non-alcoholic fatty liver disease progression in rats via the COX2 and PERK-elF2α-ATF4 pathway.
Sun Z, Zhou Z, Liao K, Liu Y, Liu Y, Wang C, Zhang Z, Wen L
Frontiers in pharmacology 2025;16:1595752
Frontiers in pharmacology 2025;16:1595752
Nrf2-dependent effects of CDDO-Me on bactericidal activity in macrophage infection models.
Deramaudt TB, Chehaitly A, Bonay M
Frontiers in immunology 2025;16:1574776
Frontiers in immunology 2025;16:1574776
Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis.
Wang Z, Sun Y, Wang J, Xu Q, Wang L, Zhang Q, Song J, Wang Y, Qi Z
Frontiers in pharmacology 2025;16:1566622
Frontiers in pharmacology 2025;16:1566622
α-Mangostin prevents diabetic cardiomyopathy by inhibiting oxidative damage and lipotoxicity through the AKT-FOXO1-CD36 pathway.
Bai X, Zhang Z, Zhang M, Xu J, Dong K, Du Q, Chen L, Ma P, Yang J
Frontiers in pharmacology 2025;16:1566311
Frontiers in pharmacology 2025;16:1566311
Suppression of NLRP3 inflammasome by a small molecule targeting CK1α-β-catenin-NF-κB and CK1α-NRF2-mitochondrial OXPHOS pathways during mycobacterial infection.
Guan Q, Xiong H, Song X, Liu S, Guang Y, Nie Q, Xie Y, Zhang XL
Frontiers in immunology 2025;16:1553093
Frontiers in immunology 2025;16:1553093
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
Yan Y, Fang M, Zhao C, Lin X, Tong C, Xiang C, Ran Y, Wang X, Li S, Chen G, Fu L
Frontiers in pharmacology 2025;16:1542296
Frontiers in pharmacology 2025;16:1542296
Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway.
Liu Y, Fu Z, Wang X, Yang Q, Liu S, Zhu D
Frontiers in pharmacology 2025;16:1527316
Frontiers in pharmacology 2025;16:1527316
Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway.
Gong S, Lang S, Jiang X, Li X
Frontiers in pharmacology 2025;16:1526623
Frontiers in pharmacology 2025;16:1526623
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
Zhu Z, Huang Z, Zhang C, Xu B, Chen H, Pei S, Zhang B, Jie L, Shi X, Liu Y, Li Y, Shen X
Frontiers in pharmacology 2025;16:1501725
Frontiers in pharmacology 2025;16:1501725
Embryonic heat conditioning induces paternal heredity of immunological cross- tolerance: coordinative role of CpG DNA methylation and miR-200a regulation.
Ravi PM, Kisliouk T, Druyan S, Haron A, Cline MA, Gilbert ER, Meiri N
Frontiers in immunology 2025;16:1487135
Frontiers in immunology 2025;16:1487135
A multifunctional injectable microsphere with enhanced near-infrared photo-antibacterial, ROS scavenging, and anti-inflammatory properties for periodontitis treatment.
Xiu Z, Zhu Y, Li X, Jiang X, Feng Y, He L, Li C, Cai R, Tao G
Theranostics 2025;15(9):3750-3780
Theranostics 2025;15(9):3750-3780
Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons.
Li J, Zhou Z, Wu Y, Zhao J, Duan H, Peng Y, Wang X, Fan Z, Yin L, Li M, Liu F, Yang Y, Du L, Li J, Zhong H, Hou W, Zhang F, Ma H, Zhang X
Theranostics 2025;15(4):1376-1398
Theranostics 2025;15(4):1376-1398
The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma.
Liu R, Li X, Xu J, Yan L, Hu K, Shi M, Zhang Y, Zhao Y, Fan Y, Wang G, Guo Y, Feng Y, Liu P
Theranostics 2025;15(17):9091-9113
Theranostics 2025;15(17):9091-9113
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Cheng Y, Zheng G, Huang H, Ni J, Zhao Y, Sun Y, Chang Y, Liu S, He F, Li D, Guo Y, Miao Y, Xu M, Wang D, Zhang Y, Hua Y, Yang S, Fan G, Ma C
Theranostics 2025;15(10):4345-4367
Theranostics 2025;15(10):4345-4367
Hydrogen improves the efficacy of tetrandrine in the treatment of silicosis by inhibiting vascular endothelial mesenchymal transition caused by oxidative stress.
Xiao K, Li M, Mu Y, Sun Y, Wang S, Chen S, Ma J, Cao M, Yang Y, Shao H, Ding X, Cui G, Du Z
Frontiers in bioengineering and biotechnology 2025;13:1668524
Frontiers in bioengineering and biotechnology 2025;13:1668524
Garlic oil-loaded nanodisks for the amelioration of acute lung injury via modulation of the NF-κB and Keap1-Nrf2 axis.
Hou R, Jiang B, Wang K, Yang X, Zhang W
Frontiers in molecular biosciences 2025;12:1686436
Frontiers in molecular biosciences 2025;12:1686436
Comparative hepatoprotective effects of AMK and PAMK via Nrf2 signaling in broiler breeders.
Lu B, He J, Pan S, Wei J, Li B, Cao N, Huang Y, Tian Y, Cheong N, Chen Y, Xu D, Li W
Frontiers in veterinary science 2025;12:1672417
Frontiers in veterinary science 2025;12:1672417
Phytochemical nanozymes reprogram redox for balanced antimicrobial and regenerative therapy in acute and chronic diabetic wounds.
Pang Y, Amona FM, Chen X, You Y, Sha Z, Liu Z, Li J, Liu Y, Fang X, Chen X
Redox biology 2025 Sep;85:103718
Redox biology 2025 Sep;85:103718
Chaperone-Mediated Autophagy Reactivation Protects Against Severe Acute Pancreatitis-Associated Liver Injury Through Upregulating Keap1/Nrf2 Signaling Pathway and Inhibiting NLRP3 Inflammasome Activation.
Li Z, Yu Y, Zhao X, Qu Y, Wang J, Zhang D
Cell biochemistry and biophysics 2025 Sep;83(3):2919-2935
Cell biochemistry and biophysics 2025 Sep;83(3):2919-2935
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
Yan Y, Huang Z, Cheng L, Zhao S, Gao H, Chen K, Huang F, Mou L, Chen G, Fu L, Xu G
Toxicology and applied pharmacology 2025 Sep;502:117424
Toxicology and applied pharmacology 2025 Sep;502:117424
Uric Acid Stimulates PINK1/Parkin-Mediated Mitophagy via Nrf2/HO-1 Pathway to Protect Against Neuronal Apoptosis in Alzheimer's Disease.
Zhang Q, Xie D, Chen B, Yu L, Chen J, Yan Y, Zhang M, Wang Q, Xi Y, Yamamoto T, Koyama H, Cheng J
Antioxidants & redox signaling 2025 Sep;43(7-9):381-399
Antioxidants & redox signaling 2025 Sep;43(7-9):381-399
Reorganization of Mitochondrial Function and Architecture in Response to Plant-Derived Alkaloids: Anatabine, Anabasine, and Nicotine, Investigated in SH-SY5Y Cells and in a Cellular Model of Parkinson's Disease.
Malińska D, Drabik K, Michalska B, Walczak J, Partyka M, Prill M, Szymański J, Patalas-Krawczyk P, Piecyk K, Duszyński J, Więckowski MR, Szczepanowska J
CNS neuroscience & therapeutics 2025 Sep;31(9):e70571
CNS neuroscience & therapeutics 2025 Sep;31(9):e70571
Nuclear export of transmembrane protein PROM2 is specially regulated by CRM1 and affects the sensitivity of ferroptosis in gastric cancer.
Zhang P, Lin W, Wu T, Rao S, Huang D, Wu J, Tao T, Hou J
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2025 Sep;28(5):837-851
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2025 Sep;28(5):837-851
High mobility group box 1, a novel serotonin receptor-7 negative modulator, contributes to M2 microglial ferroptosis and neuroinflammation in post-stroke depression.
Du O, Wu C, Yang YX, Yang HY, Wu YJ, Li MY, Liu SC, Shao ZH, Du JR
Free radical biology & medicine 2025 Sep;237:666-683
Free radical biology & medicine 2025 Sep;237:666-683
NADPH oxidase-dependent heme oxygenase-1 expression mediates cigarette smoke-induced ferroptosis via intracellular Fe(II) accumulation.
Sul OJ, Park SH, Choi HW, Kim DJ, Ra SW
Free radical biology & medicine 2025 Sep;237:131-146
Free radical biology & medicine 2025 Sep;237:131-146
Acetyl-CoA carboxylase activation disrupts iron homeostasis to drive ferroptosis.
Han Z, Han S, Fang X, Lu M, Mao Y, Shi L, Song J, Wang T, Xiao J, Xiang L, Yang C, Zhu Z, Wang Y, Feng J
Free radical biology & medicine 2025 Sep;237:110-130
Free radical biology & medicine 2025 Sep;237:110-130
METTL5 triggers the ferroptosis of cardiomyocytes in sepsis-induced myocardial injury.
Wang X, Tian Q, Li M, Liu Y
Free radical biology & medicine 2025 Sep;237:1-10
Free radical biology & medicine 2025 Sep;237:1-10
High-throughput profiling of chemical-induced gene expression across 93,644 perturbations.
Xiang L, Wang Y, Shao W, Li Q, Yu X, Wei M, Gui Y, Li S, Qin P, Hu C, Zhang G, Zhang X, Wang J, Li Y, An J, Luo Y, Liao Y, Deng J, Tai X, Xu RY, Huang L, Guo D, Zhang G, Xie Z, Deng Y, Xu J, Wang D
Nature methods 2025 Sep;22(9):1954-1963
Nature methods 2025 Sep;22(9):1954-1963
Unraveling the molecular mechanisms of paraquat toxicity: The interplay of ATF4, ferroptosis, and endoplasmic reticulum stress.
Ke J, Cai Q, Ge X, Zhang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115602
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115602
Melatonin protects dopaminergic neurons in paraquat-induced Parkinson in rats through PI3K/AKT/Nrf2 pathway.
Wang Y, Zhang X, Zhang W, Han M, Jia Q, Bo C, Shao H, Sai L, Peng C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115600
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115600
Involvement of the PINK1/Parkin signaling pathway in 4-vinylcyclohexene diepoxide-induced ovary toxicity in rats.
Che Y, Wang X, Li Q, Peng X, Liu Z, Xu W, Jiang M, Wang T, Gao J, Wang W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115572
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115572
Bioactive ROS-responsive nanotherapeutics attenuate intermittent hypoxia-induced cognitive impairment via NRF2/KEAP1/HO-1 signaling.
Huang Y, Xie H, Liu L, Zhao H, Li B, Zhang F
Neurochemistry international 2025 Sep;188:105997
Neurochemistry international 2025 Sep;188:105997
TMI, an isoflavone from the fruits of Ficus altissima Blume, overcomes K562/ADR leukemia cells resistance by targeting Nrf2.
Shen L, Xu J, Wang Y, Yao J, He X
Fitoterapia 2025 Sep;185:106688
Fitoterapia 2025 Sep;185:106688
Optimized synthesis of 5N-D and the exploration of its role as a promising anti-aging agent via AKR1B1 inhibition and PI3K/Akt/Nrf2 regulation.
Liu L, Wang C, Chen Z, Yin M, Zhang K, Zhang C, Peng S, Li M, Jiang S, Chen H
Bioorganic chemistry 2025 Sep;164:108886
Bioorganic chemistry 2025 Sep;164:108886
Agathic acid derivatives including a novel ferroptosis inhibitor from the fungus Penicillium thomii.
Zhang Y, Wang H, Xiao J, Xu W, Liu W, Luo Z, Wu P, Yang X, Zhang Z, Cheng Z
Bioorganic chemistry 2025 Sep;164:108867
Bioorganic chemistry 2025 Sep;164:108867
An SPR-based active ingredient recognition strategy for identifying PLK1-targeting withanolides as natural ferroptosis inducers.
Zhu R, Yan H, Xu W, Liang J, Xiang K, Liu Y, Yang Y, Li H, Chen L
Bioorganic chemistry 2025 Sep;164:108849
Bioorganic chemistry 2025 Sep;164:108849
Regulatory role of ATF2 in trophoblast ferroptosis via the PI3K/Akt/Nrf2 pathway in gestational diabetes mellitus.
Xia D, Zhang Y, Zhang C, Wang H
Journal of diabetes investigation 2025 Sep;16(9):1720-1732
Journal of diabetes investigation 2025 Sep;16(9):1720-1732
β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.
Lan J, Zhang W, Zeng K, Li C, He J, Li X, Yang R, Chi J, Hong Z, Wang W, Zhou C, Xiao B, Fan W, Lin J, Ou Q, Fang Y, Pan Z, Peng J, Li W, Wu X
Clinical and translational medicine 2025 Sep;15(9):e70438
Clinical and translational medicine 2025 Sep;15(9):e70438
Tectorigenin attenuates myocardial damage by doxorubicin-induced ferroptosis by activating the p62-Keap1-Nrf2/HO-1/GPX4 axis.
Xie L, Xiao S, Zhou Q, Chen W, Hu Z, Li Y, Liu Y, Ma X, Li Y
Journal of traditional and complementary medicine 2025 Sep;15(5):573-581
Journal of traditional and complementary medicine 2025 Sep;15(5):573-581
Dihydrotanshinone I targets the spike N-terminal domain to inhibit SARS-CoV-2 entry and spike-induced inflammation.
Yang C, Lu K, Wang J, Su H, Cheng L, Nong C, Pan X, Li H, Peng Z, Chen Y, Wu Y, Ma Q, Hu G, Liu S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156989
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156989
Dendrobium huoshanense improves atherosclerosis in high-fat-induced ApoE mice by regulating gut microbiota and serum metabolite profiles.
Zheng SJ, Gao XY, Diao XH, Chen ND
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156964
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156964
Artemisitene Ameliorates Diabetic Wounds by Inhibiting Ferroptosis Through Activation of the Nrf2/GPX4 Pathway.
Honghao X, Yitian B, Yuan Z, Zhengyang L, Feiya Z, Leyi C, Weiyang G, Anyuan W, Hongqiang W
Food science & nutrition 2025 Sep;13(9):e70952
Food science & nutrition 2025 Sep;13(9):e70952
Investigating the role of 1,8-Cineole in mitigating ferroptosis in a HFSD/STZ diabetes mellitus type 2-induced model: A GEO data analysis approach.
Yang H, Chen Y, Wu G, Ren P, Chen T, Liu J, Zhang B, Ma X, Jiang F, Li Y, Tao L, Shen X
European journal of pharmacology 2025 Sep 5;1002:177846
European journal of pharmacology 2025 Sep 5;1002:177846
α-Cyperone safeguards against cerebral ischaemia‒reperfusion injury through the activation of the Nrf2 signalling pathway.
Yu H, Chen Y, Qu T, Hang J, Huang X, Hu A, Wang T, Gao Y, Shao J, Li Y, Chen Y
European journal of pharmacology 2025 Sep 5;1002:177842
European journal of pharmacology 2025 Sep 5;1002:177842
Teneligliptin, a DPP4 inhibitor protects dopaminergic neurons in PD models via inhibiting of oxidative stress and ferroptosis.
Huang L, Pi J, Gu L, Liao Z, Wang W
European journal of pharmacology 2025 Sep 5;1002:177782
European journal of pharmacology 2025 Sep 5;1002:177782
Isoacteoside alleviates LPS-induced depressive-like behaviors in mice by inhibiting neuroinflammation through regulating microglial polarization and oxidative stress.
Bi J, Zhang H, Wei J, Huang X, Dong Y, Dong Y, Xie Y, Li R, Chen S, Zhao Z, Cheng B
Behavioral and brain functions : BBF 2025 Sep 29;21(1):30
Behavioral and brain functions : BBF 2025 Sep 29;21(1):30
Soluble urokinase plasminogen activator receptor promotes endoplasmic reticulum stress and apoptosis susceptibility through RAGE in sepsis acute kidney injury.
Wang B, Wang J, Qi C, Gao C, Wang Y, Zan Y, Tan Y, Wu Z, Jiang J, Suo J, Zhang J, Peng Z
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):296
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):296
Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway.
Duan H, Zhang Y, Shen A, Ren J, Zhang F, Lu Y, Wei X, Yang C, Gong J, Wang X, Du Y, Pei Q, Zhang A
Veterinary research 2025 Sep 25;56(1):182
Veterinary research 2025 Sep 25;56(1):182
Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis.
Wu B, Yang Z, Duan J, Chen Z, Xiao J, Luo Z, Jian G, Wang H, Lu G
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120441
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120441
Atractylenolide III attenuates acute kidney injury through phosphorylation of PIK3CA: Functional activation and molecular interaction analysis.
You J, Sun S, Lv D, Fan S, Yan X, Liu M, Jin J, Wang W
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120368
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120368
Disrupting mitochondrial dynamics attenuates ferroptosis and chemotoxicity via upregulating NRF2-mediated FSP1 expression.
Ma S, Qin J, Zhang Y, Luan J, Sun N, Hou G, He J, Xiao Y, Zhang W, Gao M
Cell reports 2025 Sep 23;44(9):116234
Cell reports 2025 Sep 23;44(9):116234
Inhibition of MMP9 ameliorates neutrophil extracellular traps-mediated necroptosis through regulation of impaired autophagy in severe acute pancreatitis.
Zhang H, Wang Z, Li J, Jia Y, Xie X, Ding Y, Cao F, Li F
International immunopharmacology 2025 Sep 23;162:115109
International immunopharmacology 2025 Sep 23;162:115109
Shikimic Acid Mitigates Deoxynivalenol-Induced Jejunal Barrier Injury in Mice via Activation of the Nrf-2/HO-1/NQO1 Pathway and Modulation of Gut Microbiota.
Su Y, Zheng B, Zhou C, Li M, Yuan Y, Wang H, Li B, Wu S, Wu Z, Zhao Y, Zhang W, Shu G
Antioxidants (Basel, Switzerland) 2025 Sep 23;14(10)
Antioxidants (Basel, Switzerland) 2025 Sep 23;14(10)
Sheng Mai San Mitigates Heat Stress-Induced Myocardial Injury by Coordinated Regulation of the Keap1-Nrf2-HO-1 and Stub1-HSF1 Signaling Pathways.
Dong J, Ma Q, Yang R, Zhang X, Hua Y, Ji P, Yao W, Yuan Z, Wei Y
Antioxidants (Basel, Switzerland) 2025 Sep 22;14(9)
Antioxidants (Basel, Switzerland) 2025 Sep 22;14(9)
Hydrogen Sulfide-Preconditioned Mesenchymal Stem Cells Attenuate Ferroptosis in Corneal Alkali Burn via the AMPK/Nrf2/HO-1 Pathway in an IL-10-Dependent Manner.
Chen M, Jiang Y, Yu H, Qi H, Li X, Wang J, Wang A, Li Z, Wang Q, Huang Y, Wang L
Investigative ophthalmology & visual science 2025 Sep 2;66(12):58
Investigative ophthalmology & visual science 2025 Sep 2;66(12):58
Dovitinib Ameliorates Inflammation-Related Diseases by Inhibiting Necroptosis and Ferroptosis.
Lin Y, Feng J, Zhao M, Zhang L, Li Y, Chen X, Lin C, Lin J, Lin Q, Li J, Wu L, Li L
ACS chemical biology 2025 Sep 19;20(9):2191-2203
ACS chemical biology 2025 Sep 19;20(9):2191-2203
Sinomenine Modifies Parkinson's Disease Through Nrf2 Activation.
Zhu L, Lin L, Yang Z, Tang H, Wu J, Kang Z, Feng Y, Zheng B, Hu Q, Wang S, Liu C, Jiang Z, Liu S, Wu G
Neurochemical research 2025 Sep 18;50(5):302
Neurochemical research 2025 Sep 18;50(5):302
Integrating network pharmacology and experimental validation to decipher the protective effect of icariin against testicular aging.
Sun J, Lv C, Lin Z, Luo S, Liao S, Lian X, Liu Y, Luo L, Zheng M, Zhang D, Wang X, Wang S
Ecotoxicology and environmental safety 2025 Sep 15;303:119063
Ecotoxicology and environmental safety 2025 Sep 15;303:119063
Early-life glyphosate exposure impairs intestinal antioxidant status and induces growth retardation in post-hatched chicks.
Zhang M, Tian X, Liu X, Fan Y, Bian G, Deng K, Tang Q
Ecotoxicology and environmental safety 2025 Sep 15;303:118902
Ecotoxicology and environmental safety 2025 Sep 15;303:118902
RSL1D1 regulates lung adenocarcinoma progression by inhibiting NRF2 ubiquitination.
Yang Q, Zhang C, Zhang H, Sun S, Zhao G, Yang Q, Huang X, Yan E, Li H, Liu H, Zhang WW
Gene 2025 Sep 10;964:149637
Gene 2025 Sep 10;964:149637
Transcription factor RUNX2 participates in astrocyte-mediated neuropathic pain via transcriptional activation of Ccl2.
Shen W, Song S, Zhao X, Li D, Liu J, Yue S
Biochemical and biophysical research communications 2025 Sep 1;777:152263
Biochemical and biophysical research communications 2025 Sep 1;777:152263
Influence of Sevoflurane Postconditioning on Hypoxic-Ischemic Brain Injury via Nrf2-Regulated Ferroptosis in Neonatal Rats.
Li C, Wu Z, Xue H, Gao Q, Kuai S, Zhao P
Anesthesia and analgesia 2025 Sep 1;141(3):648-659
Anesthesia and analgesia 2025 Sep 1;141(3):648-659
Helicobacter pylori modulates macrophage polarization via the glucocorticoid receptor to promote gastric cancer cell proliferation.
Wang X, Weng Y, Yao Y, Shao S, Mao L, Wang J
Tissue & cell 2025 Oct;96:103001
Tissue & cell 2025 Oct;96:103001
Codonopsis pilosula polysaccharides attenuate lipid accumulation and inflammatory response in the NAFLD mouse by regulating AMPK/ACC/SREBP1 signaling pathway.
Chen Q, Lin H, Huang X, Yu W
Tissue & cell 2025 Oct;96:102984
Tissue & cell 2025 Oct;96:102984
YAP/Nrf2 suppresses ferroptosis to alleviate acute lung injury induced by intestinal ischemia/reperfusion.
Tang L, Yang C, Peng Y, Liu M, Wei N, Fan X, Yang B, Jia J, Chen Y, Feng J, Zhou J
Redox biology 2025 Oct;86:103811
Redox biology 2025 Oct;86:103811
Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation.
Xu H, He TQ, Chen SY, Shi RR, Xu J, Xing YR, Shi D, Liu YQ, He BS, Gu JH
Redox biology 2025 Oct;86:103803
Redox biology 2025 Oct;86:103803
Oxidative modulation of Piezo1 channels.
Novosolova N, Braidotti N, Patinen T, Laitinen T, Ciubotaru C, Huttunen KM, Levonen AL, Cojoc D, Giniatullin R, Malm T
Redox biology 2025 Oct;86:103797
Redox biology 2025 Oct;86:103797
Sleep deprivation affects pain sensitivity by increasing oxidative stress and apoptosis in the medial prefrontal cortex of rats via the HDAC2-NRF2 pathway.
Chen S, Xie Y, Liang Z, Liu J, Wang J, Mao Y, Xing F, Wei X, Wang Z, Yang J, Yuan J
Biomedical journal 2025 Oct;48(5):100826
Biomedical journal 2025 Oct;48(5):100826
Non-Apoptotic Inhibition of Colorectal Cancer Proliferation by Sclareol via Ferroptosis Involving SLC7A11/GPX4 Modulation.
Li YX, Wu Y, Li Q, Huang YQ, Yuan YY, Su YN, Cheng CS, Zheng L
Phytotherapy research : PTR 2025 Oct;39(10):4677-4692
Phytotherapy research : PTR 2025 Oct;39(10):4677-4692
The SLCO4A1-Mediated Transmembrane Transport of Lysionotin Attenuates Acute Lung Injury Through Activating the AMPK/Nrf2 Signaling Pathway.
Xiong D, Lin M, Xie W, Zhang X, Huang L, Deng L, Huang X, Liu W, Tang S
Phytotherapy research : PTR 2025 Oct;39(10):4404-4427
Phytotherapy research : PTR 2025 Oct;39(10):4404-4427
The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25.
Guo Y, Zhu S, Wu W, Cai Y, Sehgal SA, Huang F, Wu H
The Journal of biological chemistry 2025 Oct;301(10):110689
The Journal of biological chemistry 2025 Oct;301(10):110689
Oligodendrocyte-specific knockout of FPN1 affects CNS myelination defects and depression-like behavior in mice.
Zhang N, Zhang S, Liu X, Zuo YY, Cui YG, Wang F, Zhang JH, Chang YZ, Yu P
Free radical biology & medicine 2025 Oct;238:370-386
Free radical biology & medicine 2025 Oct;238:370-386
Guanosine enhances thermogenesis and impairs KEAP1-mediated NRF2 degradation to resist ferroptosis in brown adipose tissue.
Tang Y, Zhao M, Wang N, Nie H, Song J, Zhou Z, Tang W, Zhang J, Li C, Fang L
Free radical biology & medicine 2025 Oct;238:360-369
Free radical biology & medicine 2025 Oct;238:360-369
Honokiol protects against heavy-ion radiation-induced oxidative damage via the thioredoxin system.
Chen Y, Shen R, Zhou X, Xu D, Wu Q, Zhang J, Fang J
Free radical biology & medicine 2025 Oct;238:235-245
Free radical biology & medicine 2025 Oct;238:235-245
Hinokitiol modulates Nrf2/HO-1 signaling, autophagy, and URAT1 in hyperuricemia and oxidative stress models of renal injury.
Chiang YF, Huang KC, Huang YJ, Wang KL, Huang YJ, Shieh TM, Ali M, Hsia SM
Free radical biology & medicine 2025 Oct;238:169-178
Free radical biology & medicine 2025 Oct;238:169-178
Limosilactobacillus reuteri-butyrate axis in depression therapy: A key pathway discovered through a novel preclinical human flora-associated animal model.
Liu X, He J, Cui L, Ye Y, Luo M, Xu H, Zhai Y, Zhao Z, Huang T, Li Y, Wu JL, Wen J, Wang Y, Zhou T
Pharmacological research 2025 Oct;220:107941
Pharmacological research 2025 Oct;220:107941
CROT overactivation within peroxisomes confers chemoresistance to non-small cell lung cancer by targeting fatty acid oxidation-Nrf2-ferroptosis resistance axis.
Hua C, Zhang G, Yu W, Zhou J, Ru L, Xue G, Zheng L, Wang M, Wang Y, Yu D, Wang Q, Liu J, Wang R, Deng W, Tang R, Guo W
Pharmacological research 2025 Oct;220:107911
Pharmacological research 2025 Oct;220:107911
Enhancing the encapsulation efficiency, bioavailability, and antioxidant efficacy of quercetin and maize peptide by a novel multi-frequency pulsed ultrasonic-assisted nanoliposomal encapsulation system.
Qu W, Deng X, Guo T, Zhou C, Ma H
Food research international (Ottawa, Ont.) 2025 Oct;218:116874
Food research international (Ottawa, Ont.) 2025 Oct;218:116874
CDDO-Me triggers ROS-dependent ferroptosis and apoptosis in cervical cancer via targeting PI3K/Nrf2 pathway.
Li W, Wang M, Du P, Han A, Feng X, Chen L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115664
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115664
Brusatol suppresses malignant progression of glioma via modulating the miR-574-5p/USP10/PLK1 axis.
Ma B, Wang L, Li J, Zhang B, Wang Y, Li N, Shen D, Han C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157142
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157142
Natural exosome-like nanovesicles from Salvia chinensis Benth induce ferroptosis to suppress hepatocellular carcinoma progression via AMPK/Nrf2/xCT axis.
Liang Z, Fang X, Zhang Z, Tao M, Gong W, Jian H, Tan X, Zeng P
Cellular signalling 2025 Oct;134:111928
Cellular signalling 2025 Oct;134:111928
Shikonin Ameliorates Alcohol-Associated Liver Disease by Reducing Oxidative Stress, Apoptosis, and Inflammation.
Gan H, Gong M, Wang L, Huang X, Chen Y, Hu Z, Li X, Zeng Q
Food science & nutrition 2025 Oct;13(10):e71064
Food science & nutrition 2025 Oct;13(10):e71064
Protective Effects Proanthocyanidin Nanoliposome Freeze-Dried Powder on Oxidative Injury in a p31-43 Induced Celiac Disease Cell Model.
Ning Z, Linlin C, Xing Z, Kunmiao H, Tiantian X, Hanshuo W, Jie S, Miao Y, Hongtao R, Na W
Food science & nutrition 2025 Oct;13(10):e71000
Food science & nutrition 2025 Oct;13(10):e71000
Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic-Induced Transformation.
Wang Z, Bi Z, Bamrah J, Qiu Y, Zhang W, Almutairy BS, Ji H, Haley JD, Thakur C, Chen F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e00221
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e00221
Ferroptosis and iron metabolism drive fibroblast activation in silicosis: insights from a novel 3D lung matrix model.
Song C, Zeng X, Wang J, Xue W, Wang Y, Wang Y, Tian L, Zhu Z
Journal of molecular medicine (Berlin, Germany) 2025 Oct;103(10):1247-1261
Journal of molecular medicine (Berlin, Germany) 2025 Oct;103(10):1247-1261
Dual-targeting antioxidant and anti-glycation strategy inhibits melanogenesis through clinical and mechanistic study.
Ye Y, Mu J, Lin S, Zhang T, Ye F, Wang Y, Xuan L, Chen C, Yang P, Wang J, Huang H
Scientific reports 2025 Oct 9;15(1):35226
Scientific reports 2025 Oct 9;15(1):35226
Lactoferrin and Osteopontin Cooperatively Promote Intestinal Epithelial Maturation in Neonatal Mice by Activating the Brg1/Notch1/Hes1 Pathway.
Zhang W, Li C, Bi R, Lu Y, Zhang Y, Shi C, Qiao Z, Sun Y, Chen J, Wang P, Wang R, Ren F, Li Y
Nutrients 2025 Oct 8;17(19)
Nutrients 2025 Oct 8;17(19)
HBHP ameliorates CCL4-induced liver fibrosis in rats by inhibiting HMGB1-mediated inflammatory response through binding to the HMGB1-A box.
Luo L, Wang S, Du R, Zhong M, Zhu W, Huang F, Ouyang W, Huang J, Tong G
European journal of pharmacology 2025 Oct 5;1004:177971
European journal of pharmacology 2025 Oct 5;1004:177971
SIRT3 mediates Tubeimoside I's inhibition on pulmonary artery smooth muscle cell proliferation and oxidative stress in pulmonary arterial hypertension.
Li Y, Zhang Y, Chen Y, Qiao Z, Wang D, Yang Y, Huang W, Yan J
European journal of pharmacology 2025 Oct 5;1004:177938
European journal of pharmacology 2025 Oct 5;1004:177938
Harpagide Confers Protection Against Acute Lung Injury Through Multi-Omics Dissection of Immune-Microenvironmental Crosstalk and Convergent Therapeutic Mechanisms.
Wang H, Yang J, Zhang Y, Wang J, Song S, Gao L, Liu M, Chen Z, Li X
Pharmaceuticals (Basel, Switzerland) 2025 Oct 4;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Oct 4;18(10)
Targeting PARK7: Sodium 4-Phenylbutyrate shields endothelial cells from oxidative stress and GSDME-mediated Pyroptosis in acute lung injury.
Xu J, Wei T, Wang Y, Zhang C, Chen X, Li Y, Song J, Mao W, Xu Q, Wu X, Song Y
International immunopharmacology 2025 Oct 30;164:115386
International immunopharmacology 2025 Oct 30;164:115386
Neuroprotective Effects and Mechanisms of Arecoline Against H(2)O(2)-Induced Damage in SH-SY5Y Cells.
Zhang X, Cui J, Sun J, Wang F, Fan B, Lu C
International journal of molecular sciences 2025 Oct 24;26(21)
International journal of molecular sciences 2025 Oct 24;26(21)
Design and Synthesis of Senescence-Targeted Prodrugs with Senomorphic and Senolytic Properties To Mitigate Chemotherapy-Induced Kidney Injury.
Ding L, Wang X, Liu Q, Zhang Y, Wu X, Xiao B, Liu D, Chen L, Zeng H, Zhao B, Dong C, Li L, Ge G, Jia L, Ni S
Journal of medicinal chemistry 2025 Oct 23;68(20):21458-21478
Journal of medicinal chemistry 2025 Oct 23;68(20):21458-21478
Apigenin Alleviates Fumonisin B1-Induced Hepatotoxicity by Suppressing Ferroptosis through the Nrf2/FSP1 Pathway.
Zhou J, Li Y, Xi C, Pan W, Yu Q, Wu Z
Journal of agricultural and food chemistry 2025 Oct 22;73(42):26999-27011
Journal of agricultural and food chemistry 2025 Oct 22;73(42):26999-27011
Menaquinone-4 ameliorates abdominal aortic aneurysm by suppressing ferroptosis through NRF2/GCLM axis.
Zhou Z, Huang L, Wu D, He R, Zhou Y, Wang K, Wang R, Yao C
Gene 2025 Oct 20;970:149785
Gene 2025 Oct 20;970:149785
Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility.
Yabaji SM, Zhernovkov V, Araveti PB, Lata S, Rukhlenko OS, Abdullatif SA, Vanvalkenburg A, Alekseyev YO, Ma Q, Dayama G, Lau NC, Johnson WE, Bishai WR, Crossland NA, Campbell JD, Kholodenko BN, Gimelbrant AA, Kobzik L, Kramnik I
eLife 2025 Oct 2;14
eLife 2025 Oct 2;14
Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway.
Luo W, Bu W, Zhang G, Dong Y, Wang Y, Wang J, Liu C, Hu X, Jia Y, Ren H
Behavioural brain research 2025 Oct 18;495:115805
Behavioural brain research 2025 Oct 18;495:115805
α-Asarone Maintains Protein Homeostasis Through SKN-1-Mediated Proteasome and Autophagy Pathways to Mitigate Aβ-Associated Toxicity in Caenorhabditis elegans.
Wei C, Chen X, Sun M, Cao J, Liao D, Cheng Z, Wang H
Antioxidants (Basel, Switzerland) 2025 Oct 18;14(10)
Antioxidants (Basel, Switzerland) 2025 Oct 18;14(10)
Impact of endogenous vasohibin 1 and vasohibin 2 gene expression on ferroptosis in a mouse cerebral infarction model.
Sun H, Hu X, Bian Z, Yu H, Bian Y, Ota-Elliott RS, An H, Liu Z, Morihara R, Fukui Y, Ishiura H, Yamashita T
Neuroscience 2025 Oct 15;585:170-180
Neuroscience 2025 Oct 15;585:170-180
Hydrogen promoted mitochondrial autophagy and alleviated CIH-induced vascular endothelial cell senescence by regulating oxidative stress.
Li D, Liu Q, Fan X, Qi K, Sun M, Song J, Guo Y, Ji E
European journal of pharmacology 2025 Oct 15;1005:178078
European journal of pharmacology 2025 Oct 15;1005:178078
Fermentation of Panax ginseng C.A. Meyer extract with lactic acid bacteria exerts hepatoprotective effects via activating the NRF2 pathway.
Liang JJ, Liu HX, Yan JG, Xie G, Liu WL, Lin JH, Li XM, Mao XL
Journal of molecular histology 2025 Oct 14;56(6):343
Journal of molecular histology 2025 Oct 14;56(6):343
Identification of disease-associated molecular signatures in the Prp-TDP-43A315T mouse model of ALS: Toward preclinical biomarker development.
Al Ojaimi Y, Osman S, Alarcan H, Emond P, Veyrat-Durebex C, Lanznaster D, Meme S, Clemencon R, Galineau L, Corcia P, Andres C, Vourc'h P, Masse F, Trovero F, Blasco H
Journal of neuropathology and experimental neurology 2025 Oct 1;84(10):911-927
Journal of neuropathology and experimental neurology 2025 Oct 1;84(10):911-927
Inhibition of ferroptosis by serine protease inhibitor attenuates acute respiratory distress syndrome.
Guo Q, Gao X, Ren J, Deng G, Li R, Zhang C, Xu X, Li J, Liu W, Qin L, Wang G
Archives of biochemistry and biophysics 2025 Nov;773:110596
Archives of biochemistry and biophysics 2025 Nov;773:110596
miR-144-3p suppression mediates Nrf2 activation induced by developmental arsenic exposure in mice.
Wu R, Chen X, Xia Y, Cui M, Hou S, Hu Y, Wang H, Pi J, Xu Y
Toxicology 2025 Nov;517:154227
Toxicology 2025 Nov;517:154227
NFE2L2 protects against Sorafenib-induced Ferroptosis and cardiotoxicity by activating the HO1/ferritin pathway.
Jiang H, Su Y, Hou Y, Wang C
Toxicology and applied pharmacology 2025 Nov;504:117537
Toxicology and applied pharmacology 2025 Nov;504:117537
Carnosol attenuates Ang II-induced renal injury by p62-KEAP1-NRF2 signaling pathway.
Fan S, Zhao Y, Zhao Q, Xu D, Chen X, Han J, Fang Z, Liang G, Zhao Y
Toxicology and applied pharmacology 2025 Nov;504:117528
Toxicology and applied pharmacology 2025 Nov;504:117528
Panax ginseng alleviates diabetic peripheral neuropathy by suppressing mitochondrial dysfunction and oxidative stress via modulation of the RAGE, NF-κB, and Nrf2 pathways.
Liu P, Yang T, Zhang J, Su B, Shi Q, Song Y, Yu X
Journal of ginseng research 2025 Nov;49(6):734-745
Journal of ginseng research 2025 Nov;49(6):734-745
NPB-1575 attenuates neuroinflammation and resists ferroptosis in rat ischemic stroke via IRS2 signaling pathway.
Li XN, Shang NY, Liu MY, Sui SY, Tang JS, Lan JQ, Kang YY, Zhang BD, Wen ZP, Feng XH, Wu L, Dai JG, Peng Y
Acta pharmacologica Sinica 2025 Nov;46(11):2893-2907
Acta pharmacologica Sinica 2025 Nov;46(11):2893-2907
ML385 increases ferroptosis via inhibiting Nrf2/HO-1 pathway to enhances the sensitivity of MCF-7 TAMR to tamoxifen.
Yuan J, Huang W, Lin M, Sun S, Zhong F, Ye L, Yin H, Ou X, Zeng Z
Naunyn-Schmiedeberg's archives of pharmacology 2025 Nov;398(11):16081-16093
Naunyn-Schmiedeberg's archives of pharmacology 2025 Nov;398(11):16081-16093
Astragaloside IV Alleviates Cisplatin Chemotherapy-Induced Nephrotoxicity via Modulation of Nrf2/HO-1/NF-κB Pathway and Reversal of EMT Process.
Ding X, Han X, Zhang Y, Zhang Y, Li F, Wang J
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70565
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70565
Preprotective Effects of Cardamomin From Amomum villosum Lour. on H(2)O(2) -Induced Oxidative Damage In Vitro and Cerebral Ischemic Stroke In Vivo.
Zhu M, Sun D, Wang H, Li Y, Li H, Chen L
Phytotherapy research : PTR 2025 Nov;39(11):5378-5390
Phytotherapy research : PTR 2025 Nov;39(11):5378-5390
Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2-HO-1 Pathway.
Qiu H, Cai C, Zhang Y, Yang S, Hu X, Chu T
Phytotherapy research : PTR 2025 Nov;39(11):4977-4990
Phytotherapy research : PTR 2025 Nov;39(11):4977-4990
Structural characterization and functional role of SLC7A6 in GSSG transport and Ferroptosis regulation.
Yan G, Chen M, Lu Z, Huang H, Wang X, Qin W, Mo S, Zhong P, Han C, Ye X
International journal of biological macromolecules 2025 Nov;330(Pt 3):148008
International journal of biological macromolecules 2025 Nov;330(Pt 3):148008
Kaempferol prevents Nrf2 from ubiquitin-mediated proteolysis to mitigate both NLRP3 inflammation and oxidative stress: implications for alleviating DSS-induced colitis in mice.
Hua W, Li M, Yan Z, Wang Y, Zhou X, Fu Z, Wang Y, Zhang S, Qian J
Inflammopharmacology 2025 Nov;33(11):6861-6876
Inflammopharmacology 2025 Nov;33(11):6861-6876
Salidroside improves bovine embryo quality by mitigating oxidative stress and regulating mitochondrial lipid metabolism.
Liu LY, Yu XF, Chi ZC, Shi SM, Lan T, Leng JH, Li JH, He YY, Qu LY, Jia GL, Kong I, Zhang MJ, Jin YX
Theriogenology 2025 Nov;247:117570
Theriogenology 2025 Nov;247:117570
Collagen peptides from Skipjack tuna (Katsuwonus pelamis) bones: Composition, characterization, and mechanism of high-fat diet-induced NAFLD amelioration.
Jiang YL, Zhang SY, Wang B, Zeng YH, Xu L, Chi CF
Food research international (Ottawa, Ont.) 2025 Nov;219:117114
Food research international (Ottawa, Ont.) 2025 Nov;219:117114
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
Liu R, Chen Y, Huang H, Li X, Lv J, Jiang L, Jiang H, Wu C, Chen W, Xu H, Zhu Z, Cai H, Xiao J, Yin L, Ni W
British journal of pharmacology 2025 Nov;182(22):5489-5516
British journal of pharmacology 2025 Nov;182(22):5489-5516
Gut microbiota-bile acid metabolic disorder involved in the cognitive impairments in epilepsy through HO-1 dependent ferroptosis.
Li X, Ji J, Li J, Li S, Luo Q, Gu M, Yin X, Zhang M, Fan H, Yao R
Journal of pharmaceutical analysis 2025 Nov;15(11):101291
Journal of pharmaceutical analysis 2025 Nov;15(11):101291
CX-5461 inhibits cell proliferation and induces ferroptosis of colorectal cancer cells by inactivating Nrf2 pathway.
Chang X, Zhang Y, Wang Q, Yang W, Zhang R, Cong X, Xiao W, Piao J, Lin Z, Jin A
Cellular signalling 2025 Nov;135:111998
Cellular signalling 2025 Nov;135:111998
Epigallocatechin-3-Gallate Mitigates Atopic Dermatitis-Like Skin Lesions and Psychiatric Comorbidities by Reducing Oxidative Stress.
Tang L, Peng R, Guo J, Wang C, Wang T, Bao Y, He Y
Food science & nutrition 2025 Nov;13(11):e71248
Food science & nutrition 2025 Nov;13(11):e71248
Anthocyanin-functionalized selenocysteine nanotherapeutics alleviate cisplatin nephrotoxicity by inhibiting oxidative stress and ferroptosis.
Zhu H, Wu X, Tan Y, Shi L, Bai W, Li X
Journal of nanobiotechnology 2025 Nov 5;23(1):703
Journal of nanobiotechnology 2025 Nov 5;23(1):703
Anthraquinone Rhein Mitigates Heavy Ion Radiation-Induced Lung Injury by Maintaining Thioredoxin Reductase/Thioredoxin (TrxR/Trx) Redox Homeostasis.
Chen Y, Wang J, Zhou X, Xu C, Xu D, Wu Q, Zhang J, Fang J
Molecular pharmaceutics 2025 Nov 3;22(11):6714-6727
Molecular pharmaceutics 2025 Nov 3;22(11):6714-6727
Taoren Honghua Jian improves ferroptosis-mediated myocardial damage following myocardial infarction via Nrf2-dependent enhancement of GPX4/FSP1.
Zhang GY, Zhang F, Xie LP, Han X, Wang ZX, Wang WL, Peng Y, Xu HL, Xu T, Pang MJ, Liu B, Wang D, Zhou YC, Wu YT
The Journal of pharmacy and pharmacology 2025 Nov 28;77(12):1726-1741
The Journal of pharmacy and pharmacology 2025 Nov 28;77(12):1726-1741
Sestrin2 ameliorates LPS-induced cardiomyocyte injury by inhibiting ferroptosis via the Nrf2/HO-1 pathway.
Yang Y, Yang P, Zheng Z, Tian Q
European journal of medical research 2025 Nov 28;31(1):3
European journal of medical research 2025 Nov 28;31(1):3
The protecting role of Ganoderma lucidum polysaccharides on the retinal neurovascular units in rats with retinal ischemia-reperfusion injury.
Long D, Li Y, Yi S, Lu X
Scientific reports 2025 Nov 28;15(1):42769
Scientific reports 2025 Nov 28;15(1):42769
FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice.
Zhou J, Wang S, Lou J, Pan B, Zhao M, Li Q, Zhou J, Du Y, Ding S, Yu M, Zhou J, Chen X, Jin L, Wang X, Hu Y, Wang Z, Li X, Zheng C, Sun J, Huang Z
Nature communications 2025 Nov 25;16(1):10430
Nature communications 2025 Nov 25;16(1):10430
Unveiling tectorigenin: A novel ferroptosis inducer targeting EGFR in bladder cancer.
Zhai J, Tan R, Yuan S, Che B, Xiong K, Lu L, Li Y, Wu C, Zhang Y, Zhang H, Tang K, Tang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157419
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157419
Mechanism and potential targets of kaempferol alleviating photothrombotic stroke via integrating experimental validation, network pharmacology, and molecular docking.
Liu M, Liu DN, Shang YF, Zhang WF, Feng WD, Fang LH, Du GH, Wang YH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157354
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157354
Neuro-skeletal crosstalk: Brain-derived 5-HT mediates the bone-protective effects of β-Sitosterol against postmenopausal osteoporosis.
Wang K, Wang L, Zhou S, Chen X, Qian L, Zhang T, Sun X, Li M, Liu M, Guo Y, Hu Y, Ma Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157248
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157248
Generation of antifungals to combat drug resistance using language models and diffusion models.
Wang Y, Dong Y, Zheng Y, Xu L, Song M, Chen J, Zhang K, Shen T, Zhao W, Lou H, Chang W
Journal of advanced research 2025 Nov 22;
Journal of advanced research 2025 Nov 22;
Metformin mitigates cisplatin-induced premature ovarian insufficiency via Sirt1/Nrf2 activation.
Zheng Y, Fu Z, Yang S, Ma Q, Liu X, Wang Y, Geng T, Hao J, Li X
Medicine 2025 Nov 21;104(47):e46122
Medicine 2025 Nov 21;104(47):e46122
Dendrobine alleviates CCl(4)-induced acute liver injury by inhibiting necroptosis through activation of the Nrf2/PPARγ/SOD2 signaling pathways.
Yang Y, Fu X, Tan L, Xian S, Fan N, Gan Q, Nan N, Hu L, Shi J, Wu Q, Zhou S
Chinese medicine 2025 Nov 2;20(1):182
Chinese medicine 2025 Nov 2;20(1):182
Synergistic antitumor activity of sorafenib and the NUPR1 inhibitor LZX-2-73 in multiple cancer models.
Liu X, Estaras M, Cosialls E, Peng L, Santofimia-Castaño P, Iovanna J
Cell death & disease 2025 Nov 17;16(1):839
Cell death & disease 2025 Nov 17;16(1):839
ChaC1-based drug screenings identify a synergistic lethal effect of auranofin and proteasome inhibitors in hepatocellular carcinoma cells.
Yu C, Liu J, Jian H, Wen B, Jiang M, Zhang B, Lin M, Lin J, Dai Z, Zhong CQ, Zheng M
Cell death discovery 2025 Nov 17;11(1):532
Cell death discovery 2025 Nov 17;11(1):532
Sotagliflozin attenuates atrial oxidative stress and the susceptibility to atrial fibrillation by activating the NRF2/HO-1 pathway.
Li F, Xie M, Zeng G, Zhu J, Zhou J, Tan S, Lin Q, Liu Q
International immunopharmacology 2025 Nov 14;165:115461
International immunopharmacology 2025 Nov 14;165:115461
AICAr Inhibition of cardiomyocyte autophagy promotes p62-dependent NRF2 expression and protection against doxorubicin toxicity.
Fassett EK, Mayer B, Fassett JT
Cellular and molecular life sciences : CMLS 2025 Nov 13;82(1):395
Cellular and molecular life sciences : CMLS 2025 Nov 13;82(1):395
Chrysin Improves Cognitive Dysfunction in Rats with Intracerebral Hemorrhage by Regulating the Nrf2/GPX4 Pathway to Inhibit Ferroptosis.
Guo D, Shao Z, Liu D, Guan Y, Lian D, Feng J, Zhang C, Peng H
Molecular neurobiology 2025 Nov 13;63(1):35
Molecular neurobiology 2025 Nov 13;63(1):35
Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes.
Serra M, Smiriglia A, Migliore C, Caddeo A, Lorito N, Tani G, Zedda G, Columbano A, Perra A, Giordano S, Kowalik MA, Morandi A
Cell death & disease 2025 Nov 10;16(1):816
Cell death & disease 2025 Nov 10;16(1):816
SGK1 inhibits oxidative injury and extracellular matrix degradation by activating the GSK-3β (Ser9)/Fyn/NRF2 pathway in pelvic organ prolapse.
Yan Y, Peng J, He W, Chen Y, Ye W, Yin Z, Cao Y
Life sciences 2025 Nov 1;380:123939
Life sciences 2025 Nov 1;380:123939
Hydroxysafflor yellow A attenuates the blood-brain barrier dysfunction and neuroinflammation through anti-inflammatory microglial polarization after intracerebral hemorrhage.
Zheng F, Guo X, Yan Q, Zhou Y, Hu E, Zhu H, Cheng M, Yu Z, Hu M, Ding R, Li H, Zhang W, Tang T, Wang Y, Li T, Deng C
Neuropharmacology 2025 Nov 1;278:110576
Neuropharmacology 2025 Nov 1;278:110576
Targeting PIM1 by Bruceine D attenuates skin fibrosis via myofibroblast ferroptosis.
Wang J, Song Y, Tan X, Wang T, Shi Y, Xu X, Du J, Yu Z, Song B
Redox biology 2025 May;82:103619
Redox biology 2025 May;82:103619
Optineurin Cooperates With NRF2 to Regulate Tooth Root Morphogenesis by Controlling Mitochondrial Dynamics and Apoptosis.
Liu H, Zhang X, Ge X, Hsu C, Wang Y, Chen S, Yan X, Xu R, Ma J, Guo S
Cell proliferation 2025 May;58(5):e13799
Cell proliferation 2025 May;58(5):e13799
Therapeutic effect of edaravone on osteoarthritis: targeting NRF2 signaling and mitochondrial function.
Jiang C, Gong Y, Wu X, Chen J, Chen Y, Chen J, Tang F, Fang Z, Bao Y, Ye J, Wang Z, Hong Z
Journal of orthopaedic translation 2025 May;52:220-232
Journal of orthopaedic translation 2025 May;52:220-232
Methyltransferase-like enzyme 14 exacerbates retinal ganglion cell damage and diabetic retinopathy through N6-methyladenosine-dependent upregulation of pleckstrin homology domain and leucine rich repeat protein phosphatase 2.
Chen L, Wei T, Liu X, Cui L, Hu C, Quan Y
Toxicology and applied pharmacology 2025 May;498:117304
Toxicology and applied pharmacology 2025 May;498:117304
Sirt1 overexpression inhibits chondrocyte ferroptosis via Ftl deacetylation to suppress the development of osteoarthritis.
Xiong X, Huang H, Wang N, Zhou K, Song X
Journal of bone and mineral metabolism 2025 May;43(3):203-215
Journal of bone and mineral metabolism 2025 May;43(3):203-215
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
Al-Maamari A, Sultan M, Wu S, Zhang T, Wang C, Han B, Duan Y, Ding SS, Chen N, Zhang H, Sun F, Chen X, Yu D, Su S
International journal of biological macromolecules 2025 May;310(Pt 4):143549
International journal of biological macromolecules 2025 May;310(Pt 4):143549
Astragalus polysaccharide alleviates oxidative stress and senescence in chondrocytes in osteoarthritis via GCN2/ATF4/TXN axis.
Chen K, Qin C, Ji C, Yu Y, Wu Y, Xu L, Jiang Y, Zou G
International journal of biological macromolecules 2025 May;310(Pt 3):143285
International journal of biological macromolecules 2025 May;310(Pt 3):143285
11,12-Diacetyl-Carnosol Ameliorates Depression-Like Behaviors and Memory Dysfunction in CUMS Mouse Model via Inhibiting HMGB1-Mediated Neuroinflammation.
Zhao K, Xiang L, Yang S, Chen X, Yang X, Dong J, Wu S, Yang S, Zhang M, Hu W
CNS neuroscience & therapeutics 2025 May;31(5):e70406
CNS neuroscience & therapeutics 2025 May;31(5):e70406
Hyaluronic acid-modified PtPdCo-CQ nanocatalyst with triple enzyme-like activities regulates macrophage polarization and autophagy levels for the treatment of rheumatoid arthritis.
Zhang L, Wu G, Yao J, Wang D, Gao F, Qian Z
International journal of biological macromolecules 2025 May;309(Pt 4):143143
International journal of biological macromolecules 2025 May;309(Pt 4):143143
Isoquercetin alleviates osteoarthritis via regulating the NOX4/Nrf2 redox imbalance in senescent chondrocytes.
Zhou S, Liao F, Wen H
International journal of biological macromolecules 2025 May;306(Pt 2):141562
International journal of biological macromolecules 2025 May;306(Pt 2):141562
Bacteria escape macrophage-mediated phagocytosis via targeting apurinic/apyrimidinic endonuclease 1 in sepsis.
Zhou Y, Yan X, Wu Y, Qi Y, Yu T, Pan F, He L, Guo Z, Hu Z
International journal of biological macromolecules 2025 May;305(Pt 2):141278
International journal of biological macromolecules 2025 May;305(Pt 2):141278
Glucomannogalactan inhibits senescence by promoting nuclear translocation of NRF2.
Liang Z, Tang Q, Liang H, Liang X, Fu C, Kang W, Zhang Y, Lv P
International journal of biological macromolecules 2025 May;305(Pt 1):141059
International journal of biological macromolecules 2025 May;305(Pt 1):141059
Salvianolic acid B protects against UVB-induced HaCaT cell senescence and skin aging through NRF2 activation and ROS scavenging.
Sun JM, Liu YX, Tsai YT, Liu YD, Ho CK, Wen DS, Tsai TY, Zheng DN, Gao Y, Zhang YF, Yu L
Journal of photochemistry and photobiology. B, Biology 2025 May;266:113139
Journal of photochemistry and photobiology. B, Biology 2025 May;266:113139
EPA-enriched lipid from Apostichopus japonicus byproducts mitigates UVB-induced oxidative stress and inflammation by gut-skin axis.
Qu C, Liang S, Wang K, He Y, Ju W, Sun Y, Miao J
Food research international (Ottawa, Ont.) 2025 May;208:116085
Food research international (Ottawa, Ont.) 2025 May;208:116085
Shenqi granules enhance recovery from cerebral ischemia-reperfusion injury by modulating tryptophan and tyrosine metabolism and activating NFE2L2/NRF2.
Liu HX, Yang MK, Li YC, Liu CX, Li GP, Meng XL, Pei K, Wen SY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156623
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156623
Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality.
Xi H, Shan W, Li M, Wang Z, Li Y
Andrology 2025 May;13(4):911-920
Andrology 2025 May;13(4):911-920
Methyl 3,4-dihydrobenzoate attenuates muscle fiber necroptosis and macrophage pyroptosis by regulating oxidative stress in inflammatory myopathies.
Tang Q, Cheng J, Zhu T, Zhou Z, Xia P
International immunopharmacology 2025 May 8;154:114608
International immunopharmacology 2025 May 8;154:114608
Cell-Free Fat Extract for the Treatment of Lumbar Disc Degeneration: A Novel Approach Using Adipose-Derived Biologic.
Xu C, Zhou X, Yang C, Zhou F, Xie Y
Biomedicines 2025 May 30;13(6)
Biomedicines 2025 May 30;13(6)
Creatine ameliorates the adverse effects of high-fat diet on hepatic lipid metabolism, intestinal health, muscle growth and flesh quality in juvenile largemouth bass (Micropterus salmoides).
Song YF, Feng GL, Lai XH, Hu NJ, Liang JN
The British journal of nutrition 2025 May 28;133(10):1297-1308
The British journal of nutrition 2025 May 28;133(10):1297-1308
Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury.
Yang Z, Tai Y, Lan T, Zhao C, Gao JH, Tang CW, Tong H
Journal of clinical and translational hepatology 2025 May 28;13(5):409-417
Journal of clinical and translational hepatology 2025 May 28;13(5):409-417
PICK1 overexpression ameliorates endotoxin-induced acute lung injury by regulating mitochondrial quality control via maintaining Nrf-2 stabilization through activating the PI3K/Akt/GSK-3β pathway and disrupting the E3 ubiquitin ligase adapter β-TrCP.
Qian M, Zhu Y, Lin W, Lian H, Xia Y, Papadimos T, Wang J
International immunopharmacology 2025 May 27;156:114685
International immunopharmacology 2025 May 27;156:114685
Study on the Mechanism of Dihydromyricetin in Alleviating Depressive-Like Behavior in Rats Based on Network Pharmacology.
Li X, Chen M, Wei D, Wei P, Jiang Y, Chen J, Duan X, Wang Z, Zhang Y, Bai D, Jia H, Jin G
Neurochemical research 2025 May 26;50(3):171
Neurochemical research 2025 May 26;50(3):171
The antioxidant stress effect of granulin precursor in vitiligo.
Guo H, Chen J, Jiang L
Scientific reports 2025 May 25;15(1):18189
Scientific reports 2025 May 25;15(1):18189
Protective Effect of Zeaxanthin from Lycium barbarum L. on Ultraviolet B-Induced Skin Photodamage in Mice Through Nrf2-Related Pathway.
Zhu L, Shen Q, Xu Y, Li C
Antioxidants (Basel, Switzerland) 2025 May 25;14(6)
Antioxidants (Basel, Switzerland) 2025 May 25;14(6)
Melatonin inhibits salivary gland epithelial cell ferroptosis via the NRF2/HO-1/GPX4 signaling pathway in primary Sjögren's syndrome.
Weng X, Wang S, Wang Q, Wei M, Cheng B
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 May 24;74(1):84
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 May 24;74(1):84
Sheng Mai San Modulates the Heart-Gut-Microbiota Axis to Mitigate Heat Stress-Induced Damage in Rats.
Dong J, Li X, Xiao W, Zhang X, Ji P, Wei Y
Life (Basel, Switzerland) 2025 May 23;15(6)
Life (Basel, Switzerland) 2025 May 23;15(6)
Fisetin Attenuates Zinc Overload-Induced Hepatotoxicity in Mice via Autophagy-Dependent Nrf2 Activation.
Huang F, Wang Z, Zhou M, Zhang Q, Feng J
International journal of molecular sciences 2025 May 22;26(11)
International journal of molecular sciences 2025 May 22;26(11)
Study on Cellular Mechanism of Improving Inflammatory Effect of Gastrodin.
Zheng X, Gong T, Yu W, Xu S, Tang C, Zhong Y, Zhu Z
The Tohoku journal of experimental medicine 2025 May 2;265(4):249-259
The Tohoku journal of experimental medicine 2025 May 2;265(4):249-259
Targeting HMGB2 acts as dual immunomodulator by bolstering CD8(+) T cell function and inhibiting tumor growth in hepatocellular carcinoma.
Qu WF, Zhu GQ, Yang R, Chu TH, Guan ZQ, Huang R, Tian MX, Jiang XF, Tao CY, Fang Y, Gao J, Wu XL, Chen JF, Zhao QF, Wang Y, Bu YC, Zhou J, Fan J, Liu WR, Tang Z, Shi YH
Science advances 2025 May 2;11(18):eads8597
Science advances 2025 May 2;11(18):eads8597
Orientin attenuates UVB-induced skin photodamage by inhibiting ROS generation via the AMPK/Nrf2 axis.
Ma T, He J, Long Q, Wang Y, Chen F, Chen S, Xu K, Cao Y
International immunopharmacology 2025 May 16;155:114655
International immunopharmacology 2025 May 16;155:114655
Exposure to Sucralose and Its Effects on Testicular Damage and Male Infertility: Insights into Oxidative Stress and Autophagy.
Chiang YF, Chen YC, Huang KC, Ali M, Hsia SM
Environmental health perspectives 2025 May 16;
Environmental health perspectives 2025 May 16;
Unraveling the impact of micro- and nano-sized polymethyl methacrylate on gut microbiota and liver lipid metabolism: Insights from oral exposure studies.
Zheng PC, Pan XQ, Zhou YJ, Lai KP, Li R, Zhang XX
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126157
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126157
Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata.
Xu W, Li XJ, Zhong YS, He JQ, Xie W, Kang YK, Ying HZ, Yu CH
Carbohydrate polymers 2025 May 15;356:123381
Carbohydrate polymers 2025 May 15;356:123381
Far-Infrared Radiation Ameliorates the Cognitive Dysfunction in an Alzheimer's Disease Transgenic Mouse via Modulating Jak-2/Stat3 and Nrf-2/HO-1 Pathways.
Yang W, Yu Q, Wang N, Lam KK, Lin ZX, Xian YF
Neuromolecular medicine 2025 May 15;27(1):34
Neuromolecular medicine 2025 May 15;27(1):34
The STEAP4 target NQO1 mediates colon tumorigenesis.
Yin K, Villareal L, Wu X, Arcos M, Lee J, Martin DR, In JG, Leslie K, Zhang DD, Xue X
Journal of cell science 2025 May 15;138(10)
Journal of cell science 2025 May 15;138(10)
CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer.
Ma X, Zhang B, Yin X, Yang S, Lin Z, Yang Y, Zhou X
Breast cancer research : BCR 2025 May 12;27(1):74
Breast cancer research : BCR 2025 May 12;27(1):74
Dauricine Impedes the Tumorigenesis of Lung Adenocarcinoma by Regulating Nrf2 and Reactive Oxygen Species.
Yousuf W, Siddiqui NZ, Ali P, Cheng S, Ansari I, Song J, Dai M, Qiu Z, Zhu Y, Zhang Y, Liu S, Zhang Y, Liu Z, Liu H
Cells 2025 May 12;14(10)
Cells 2025 May 12;14(10)
Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes.
Guo Z, Liu S, Hou X, Zhou X, Wang Y, Rong Y, Li X, Yang R, Ma K
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Tea Polyphenols Mitigate Radiation-Induced Ferroptosis and Intestinal Injury by Targeting the Nrf2/HO-1/GPX4 Signaling Pathway.
Li R, Li L, Wu H, Gan H, Wu Z, Gu R, Zhu X, Liu S, Meng Z, Dou G
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
The anti-Alzheimer's disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway.
Lu Q, Shao N, Fang Z, Ouyang Z, Shen Y, Yang R, Liu H, Cai B, Wei T
Chemico-biological interactions 2025 May 1;412:111459
Chemico-biological interactions 2025 May 1;412:111459
Lentinan alleviates cadmium-induced kidney injury by reducing cadmium accumulation via promoting cadmium excretion and metallothionein synthesis and regulating silencing information regulator1/nuclear factor erythroid 2-related factor 2/nuclear factor kappa-B signaling pathway.
Wang X, Zhao G, Zhao Q, Hu M, Wang Y, Li Q, Wang S, Qiao M, Shen Y, Li N, Huang X, Wang D, Gan RY, Song L
Journal of food science 2025 Mar;90(3):e70163
Journal of food science 2025 Mar;90(3):e70163
Hsa-miR-532-3p protects human decidual mesenchymal stem cells from oxidative stress in recurrent spontaneous abortion via targeting KEAP1.
Zhou H, Zhou J, Liu S, Niu J, Pan J, Li R
Redox biology 2025 Mar;80:103508
Redox biology 2025 Mar;80:103508
Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles alleviates atherosclerosis by suppressing macrophage ferroptosis via the NRF2/SLC7A11/GPX4 pathway.
Jin M, Chen X, Zheng L, Peng Y, Lin M, Liang K, Liu X, Xu Z, Yang Y, Wei B, Wan J
Archives of biochemistry and biophysics 2025 Mar;765:110316
Archives of biochemistry and biophysics 2025 Mar;765:110316
Inhibition of Phosphodiesterase 4 Suppresses Neuronal Ferroptosis After Cerebral Ischemia/Reperfusion.
Chen K, Xu B, Long L, Wen H, Zhao Q, Tu X, Wang J, Xu J, Wang H
Molecular neurobiology 2025 Mar;62(3):3376-3395
Molecular neurobiology 2025 Mar;62(3):3376-3395
Curcumin Alleviates Microglia-Mediated Neuroinflammation and Neuronal Ferroptosis Following Experimental Subarachnoid Hemorrhage by Modulating the Nrf2/HO-1 Signaling Pathway.
Xu Y, Liu Y, Wu Y, Sun J, Lu X, Dai K, Zhang Y, Luo C, Zhang J
Molecular neurobiology 2025 Mar;62(3):2995-3010
Molecular neurobiology 2025 Mar;62(3):2995-3010
Pleiotrophin Prevents H(2)O(2)-Induced Senescence of Dental Pulp Stem Cells.
Liu C, Lei W, Zhang L, Zhang C, Gao R, Jin L
Journal of oral rehabilitation 2025 Mar;52(3):391-400
Journal of oral rehabilitation 2025 Mar;52(3):391-400
The potential role of the SIRT1-Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress.
Zheng Z, Zhang P, Fu Y, Jiang Y, Zhu J, Wang F, Li S, Zhang Z, Chang T, Li T, Zhang M, Ruan B, Wang X
Cell biology international 2025 Mar;49(3):262-276
Cell biology international 2025 Mar;49(3):262-276
AKAP1/PKA-mediated GRP75 phosphorylation at mitochondria-associated endoplasmic reticulum membranes protects cancer cells against ferroptosis.
Liu H, Zheng S, Hou G, Dai J, Zhao Y, Yang F, Xiang Z, Zhang W, Wang X, Gong Y, Li L, Zhang N, Hu Y
Cell death and differentiation 2025 Mar;32(3):488-505
Cell death and differentiation 2025 Mar;32(3):488-505
The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress.
Li K, Lu L, Yao X, Wu Z, Sun P, Wen X, Li X, Wang K, Yin X
Regenerative therapy 2025 Mar;28:126-133
Regenerative therapy 2025 Mar;28:126-133
Single amino acid substitution analogs of marine antioxidant peptides with membrane permeability exert a marked protective effect against ultraviolet-B induced damage.
Huang Y, He Q, Zhang P, Song J, Wang Y, Zhu S, Lv Y, Zhou D, Hu Y, Zhang L, Liu G, Wang Q
Journal of photochemistry and photobiology. B, Biology 2025 Mar;264:113120
Journal of photochemistry and photobiology. B, Biology 2025 Mar;264:113120
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease.
Wang H, Zhao X, Wang X, Gong Y, Li S, Gu Y, He B, Wang J
Biochemical pharmacology 2025 Mar;233:116795
Biochemical pharmacology 2025 Mar;233:116795
USP13 facilitates a ferroptosis-to-autophagy switch by activation of the NFE2L2/NRF2-SQSTM1/p62-KEAP1 axis dependent on the KRAS signaling pathway.
Chen L, Ning J, Linghu L, Tang J, Liu N, Long Y, Sun J, Lv C, Shi Y, Tao T, Xiao D, Cao Y, Wang X, Liu S, Li G, Zhang B, Tao Y
Autophagy 2025 Mar;21(3):565-582
Autophagy 2025 Mar;21(3):565-582
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
Li S, Yin Y, Dong X, Xu L, Yang Z, Li H, Zou Y, Wu Z
Biological trace element research 2025 Mar;203(3):1539-1554
Biological trace element research 2025 Mar;203(3):1539-1554
Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice.
Zhang X, Wang G, Chen S
Biological trace element research 2025 Mar;203(3):1494-1501
Biological trace element research 2025 Mar;203(3):1494-1501
The protective effect and potential mechanism of Zanthoxylum bungeanum Maxim. on atherosclerosis.
Li Z, Xu R, Li C, Chi C, Yang X, Yang S, Liu R
Fitoterapia 2025 Mar;181:106394
Fitoterapia 2025 Mar;181:106394
Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function.
Liao X, Tang M, Li J, Guo R, Zhong C, Chen X, Zhang X, Mo H, Que D, Yu W, Song X, Li H, Cai Y, Yang P
Advanced healthcare materials 2025 Mar;14(7):e2404319
Advanced healthcare materials 2025 Mar;14(7):e2404319
Oxymatrine alleviates ALD-induced cardiac hypertrophy by regulating autophagy via activation Nrf2/SIRT3 signaling pathway.
Lu D, Wu S, Wang X, Zhang J, Xu Y, Tao L, Shen X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156389
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156389
Rosa roxburghii Fermentation Broths Attenuate Bleomycin-Induced Pulmonary Fibrosis by Activating the Nrf2/HO-1/NQO1 Signaling Pathway and Modulating Gut Microbiota.
Zhou H, Zheng X, Huang S, Wang X, Zhou T, Zhang S, Ling Y, Wang W, Li X, Li S, Xie Y, Yin W
Food science & nutrition 2025 Mar;13(3):e70105
Food science & nutrition 2025 Mar;13(3):e70105
Redox-Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3-Mediated NRF2 Deubiquitination.
Xu W, Hua Z, Wang Y, Tang W, Ge W, Chen Y, Wang Z, Gu Y, Liu CY, Du P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2411320
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2411320
The Lactate-Primed KAT8‒PCK2 Axis Exacerbates Hepatic Ferroptosis During Ischemia/Reperfusion Injury by Reprogramming OXSM-Dependent Mitochondrial Fatty Acid Synthesis.
Yuan J, Yang M, Wu Z, Wu J, Zheng K, Wang J, Zeng Q, Chen M, Lv T, Shi Y, Yang J, Yang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2414141
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2414141
Gaudichaudione H Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Disulfidptosis via Regulating NRF2-SLC7A11 Signaling Pathway.
Shi M, Li X, Guo Y, Zhang Y, Xu J, Yan L, Liu R, Wang H, Tang S, Zhao Y, Li Z, Feng Y, Ren D, Liu P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2411131
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2411131
Procyanidin B2 alleviates damage to mouse testicular tissue after freezing by inhibiting oxidative stress and apoptosis.
Cao G, Li C, Zhang J, Deng L, Li R, Xu C
Cryobiology 2025 Mar;118:105196
Cryobiology 2025 Mar;118:105196
Moscatilin Induces Ferroptosis in Clear Cell Renal Cell Carcinoma via the JAK-STAT Signaling Pathway.
Chen P, Yang J, Chen L, Liu C, Li Z, Long X, Wu J, Wu B, Wu J
Chemical biology & drug design 2025 Mar;105(3):e70071
Chemical biology & drug design 2025 Mar;105(3):e70071
Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.
Cheng C, Zhang S, Chen C, Gong Y, Ding K, Li G, Jiang W, Zhang Z, He B, Hu Z, Li Y, Yao L
Scientific reports 2025 Mar 9;15(1):8141
Scientific reports 2025 Mar 9;15(1):8141
The predominant role of p62/SQSTM1 over NBR1 in methylmercury-induced cytotoxicity and cellular defense.
Takanezawa Y, Sakai K, Nakamura R, Ohshiro Y, Uraguchi S, Kiyono M
Biochemical and biophysical research communications 2025 Mar 8;752:151461
Biochemical and biophysical research communications 2025 Mar 8;752:151461
Network pharmacology and in vivo study: Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis.
Qin Y, Zhang RY, Zhang Y, Zhao YQ, Hao HF, Wang JP
World journal of gastroenterology 2025 Mar 7;31(9):100271
World journal of gastroenterology 2025 Mar 7;31(9):100271
Fructose-Driven glycolysis supports synaptic function in subterranean rodent - Gansu Zokor (Eospalax cansus).
Li M, Liu T, Zhang Y, Yang M, Li Z, He J, Li J
Neuroscience 2025 Mar 5;568:139-153
Neuroscience 2025 Mar 5;568:139-153
Multifunctional Liposome Delivery System Based on Ursodeoxycholic Acid Sodium for the Encapsulation of Silibinin and Combined Treatment of Alcoholic Liver Injury.
Wang Y, Yuan M, Li S, Tang J, Wan Y, Liang X, Guo Y, Guo L
Molecular pharmaceutics 2025 Mar 3;22(3):1480-1497
Molecular pharmaceutics 2025 Mar 3;22(3):1480-1497
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Xu Y, You J, Yao J, Hou B, Wang W, Hao Z
Urolithiasis 2025 Mar 29;53(1):61
Urolithiasis 2025 Mar 29;53(1):61
BRD4 Mediates Cadmium-Induced Oxidative Stress and Kidney Injury in Mice via Disruption of Redox Homeostasis.
Chen J, Guo G, Wang X, Li Z, Ji T, Li Y, Dong H, Zhang H, Gao M
Toxics 2025 Mar 29;13(4)
Toxics 2025 Mar 29;13(4)
Phenolics and Phenolic Glycosides from Wrightia pubescens and Their Hepatoprotective Activities.
Chen X, Yi P, Lv H, Zhang M, Yang J, Zhang Z, Zhao Z, Mu Y, Han L, Huang X
Journal of natural products 2025 Mar 28;88(3):631-643
Journal of natural products 2025 Mar 28;88(3):631-643
Running a genetic stop sign accelerates oxygen metabolism and energy production in horses.
Castiglione GM, Chen X, Xu Z, Dbouk NH, Bose AA, Carmona-Berrio D, Chi EE, Zhou L, Boronina TN, Cole RN, Wu S, Liu AD, Liu TD, Lu H, Kalbfleisch T, Rinker D, Rokas A, Ortved K, Duh EJ
Science (New York, N.Y.) 2025 Mar 28;387(6741):eadr8589
Science (New York, N.Y.) 2025 Mar 28;387(6741):eadr8589
Agomelatine Alleviates Depressive-like Behaviors by Suppressing Hippocampal Oxidative Stress in the Chronic Social Defeat Stress Model.
Zhu Y, Li Y, Yu Z, Chen X, Lan T, Wang M, Yu S
Antioxidants (Basel, Switzerland) 2025 Mar 28;14(4)
Antioxidants (Basel, Switzerland) 2025 Mar 28;14(4)
Total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack prevents acetaminophen-induced liver injury by activating Keap1/Nrf2 and PI3K/AKT/mTOR signaling pathway.
Guo M, Fu W, Zhang X, Li T, Ma W, Wang H, Wang X, Feng S, Sun H, Zhang Z, Zuo S, Wang Z, Xu H
Journal of ethnopharmacology 2025 Mar 26;344:119562
Journal of ethnopharmacology 2025 Mar 26;344:119562
Wedelolactone activates the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways to alleviate oxidative stress and ferroptosis and improve sepsis-induced liver injury.
Yin Y, Mu F, Zhang L, Zhao J, Gong R, Yin Y, Zheng L, Du Y, Jin F, Wang J
Journal of ethnopharmacology 2025 Mar 26;344:119557
Journal of ethnopharmacology 2025 Mar 26;344:119557
Ditan Decoction ameliorates vascular dementia-induced cognitive dysfunction through anti-ferroptosis via the HIF1α pathway: Integrating network pharmacology and experimental validation.
Gu M, Sun L, Yang J, Wang K, Wu F, Zheng L, Shen X, Lai X, Gong L, Peng Y, Xu S, Yang J, Yang C
Journal of ethnopharmacology 2025 Mar 26;344:119459
Journal of ethnopharmacology 2025 Mar 26;344:119459
Zuogui Pills alleviate iron overload-induced osteoporosis by attenuating ROS-mediated osteoblast apoptosis via the PI3K-AKT pathway and mitigating mitochondrial damage.
Lin Y, He Q, Chen B, Li Z, Chen C, Deng W, Li H, Yang J, Mai B, Zhang Z, Wang D, Guo H, Tang Y, Yuan K, Mo G, Xu L, Li Y, Wang H, Zhang S
Journal of ethnopharmacology 2025 Mar 26;344:119455
Journal of ethnopharmacology 2025 Mar 26;344:119455
Reprogramming Macrophage Phenotype Using a Reactive Oxygen Species-Responsive Liposome Delivery System for Inflammation Microenvironment Remodeling and Osteoarthritis Treatment.
Lai P, Ma Y, Sang W, Zhou Q, Chen H, Wang C, Yin J, Wang T, Zhu L, Zhou X, He C, Ma J
ACS applied materials & interfaces 2025 Mar 26;17(12):17932-17947
ACS applied materials & interfaces 2025 Mar 26;17(12):17932-17947
Adverse Outcome Pathway-Based Strategies to Mitigate Ag(2)Se Quantum Dot-Induced Neurotoxicity.
Yao Y, Wang Z, Huang X, Wei T, Liu N, Zou L, Niu Y, Hu Y, Fang Q, Wang X, Qiao D, Li C, Chen M, Guan S, Xue Y, Wu T, Zhang T, Tang M
ACS nano 2025 Mar 25;19(11):11029-11048
ACS nano 2025 Mar 25;19(11):11029-11048
Gastrodia elata, Polygonatum sibiricum, and Poria cocos as a Functional Food Formula: Cognitive Enhancement via Modulation of Hippocampal Neuroinflammation and Neuroprotection in Sleep-Restricted Mice.
Zhang Y, Chen F, Li X, Xu Y, Liu X, Barkat MQ, Choudhary MI, Chang Q, Jiang N
Foods (Basel, Switzerland) 2025 Mar 22;14(7)
Foods (Basel, Switzerland) 2025 Mar 22;14(7)
ROS-responsive nanoparticles with selenomethionine for ferroptosis modulation in abdominal aortic aneurysm.
He H, Chen L, Peng J, Guo J, Xiao X, Dou C, Chen H, Zhan S, Han X, Yao W
iScience 2025 Mar 21;28(3):111880
iScience 2025 Mar 21;28(3):111880
Anti-TNFα and Anti-IL-1β Monoclonal Antibodies Preserve BV-2 Microglial Homeostasis Under Hypoxia by Mitigating Inflammatory Reactivity and ATF4/MAPK-Mediated Apoptosis.
Zhang L, Guan C, Wang S, Pfeiffer N, Grus FH
Antioxidants (Basel, Switzerland) 2025 Mar 19;14(3)
Antioxidants (Basel, Switzerland) 2025 Mar 19;14(3)
BMAL1 rescued the hippocampus-dependent recognition memory induced by sleep deprivation.
Li X, Zheng Q, Yu H, Du T, Hu T, Gao L, Jia L, Sun Q
Neuroscience 2025 Mar 17;569:1-11
Neuroscience 2025 Mar 17;569:1-11
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
Ma C, Zhang L, Huang Q, Deng Q, Huang F, Xu J
Food & function 2025 Mar 17;16(6):2589-2597
Food & function 2025 Mar 17;16(6):2589-2597
Down-regulation of TET2 inhibits testosterone synthesis in offspring mice exposed to DBP during pregnancy through LH/cAMP/PKA/StAR signaling mediated by LHR.
Li H, Zhou W, Wang H, Zhang J, Sun X, Qu Z, Yu J, Cai Z, Xu X
Ecotoxicology and environmental safety 2025 Mar 15;293:118025
Ecotoxicology and environmental safety 2025 Mar 15;293:118025
The mechanism of Se in regulating the proliferation and apoptosis of sheep Leydig cells through the miR-200a/NRF2 pathway.
Li K, Wang X, Ma L, Ren Y, Shi L
Theriogenology 2025 Mar 15;235:103-113
Theriogenology 2025 Mar 15;235:103-113
Huachansu Injection induces ferroptosis in multiple myeloma through NRF2/HO-1 signaling pathway.
Yang J, Wang F, Hu Z, Liu X, Zhang W, Li C, Wang W, Reaila J, Zhang X, Zhu G, Tian F, Chen B, Zhu X
Journal of ethnopharmacology 2025 Mar 13;343:119454
Journal of ethnopharmacology 2025 Mar 13;343:119454
Gal-3 activates Tyro3 to ameliorate ferroptosis of hippocampal neurons after traumatic brain injury.
Zhang X, Li M, Xu Y, Wu J, Yuan R, Sun Y, Chen X, Lv M, Jin B, Chen X, Liang W
Molecular therapy. Nucleic acids 2025 Mar 11;36(1):102433
Molecular therapy. Nucleic acids 2025 Mar 11;36(1):102433
A novel KEAP1 inhibitor, tiliroside, activates NRF2 to protect against acetaminophen-induced oxidative stress and acute liver injury.
Cai F, Zhou K, Wang P, Zhang W, Liu L, Yang Y
Hepatology communications 2025 Mar 1;9(3)
Hepatology communications 2025 Mar 1;9(3)
Merestinib inhibits cuproptosis by targeting NRF2 to alleviate acute liver injury.
Luo X, Linghu M, Zhou X, Ru Y, Huang Q, Liu D, Ji S, Ma Y, Luo Y, Huang Y
Free radical biology & medicine 2025 Mar 1;229:68-81
Free radical biology & medicine 2025 Mar 1;229:68-81
Astaxanthin ameliorates benzalkonium chloride-induced dry eye disease through suppressing inflammation and oxidative stress via Keap1-Nrf2/HO-1 signaling pathways.
Liu Z, Li Y, Bao J, Li S, Wen Y, Zhang P, Feng J, Wang Y, Tian L, Jie Y
Animal models and experimental medicine 2025 Jun;8(6):1056-1079
Animal models and experimental medicine 2025 Jun;8(6):1056-1079
Administration with Yangxinshi ameliorates the progression of atrial fibrillation by affecting atrial remodeling and oxidative stress via the activation of the PI3K/AKT signaling.
Zhang B, Hou J, Dong L, Sun M, Dong Y, Dong Y
Cytotechnology 2025 Jun;77(3):121
Cytotechnology 2025 Jun;77(3):121
GSK3β Substrate-competitive Inhibitors Regulate the gut Homeostasis and Barrier Function to Inhibit Neuroinflammation in Scopolamine-induced Alzheimer's Disease Model Mice.
Zhang L, Jiang Z, Hu S, Ni H, Zhao Y, Tan X, Lang Y, Na R, Li Y, Du Q, Li QX, Dong Y
Inflammation 2025 Jun;48(3):1438-1459
Inflammation 2025 Jun;48(3):1438-1459
Vitamin D Activates Nrf2 to Prevent Nerve Injury and Reduce Brain Damage in Acute Cerebral Infarction.
Zhao HM, Mu LQ, Wang J, Chen RZ, Li Y, Zhao L, Zhao Y, Liu LN
Current medical science 2025 Jun;45(3):469-480
Current medical science 2025 Jun;45(3):469-480
Fisetin alleviates oxidative stress and promotes porcine early embryonic development via activation of the NRF2-ARE signalling pathway.
Wei HK, Qi JJ, Wang YQ, Qu HX, Yan CX, Li TT, Wang Y, Sun H, Sun BX, Liang S
Animal bioscience 2025 Jun;38(6):1160-1174
Animal bioscience 2025 Jun;38(6):1160-1174
Melatonin attenuates brain edema via the PI3K/Akt/Nrf2 pathway in rats with cerebral ischemia-reperfusion injury.
Liu Y, Wang X, Li Z, Gao X, Wu X, Pi J, Wang X, Wang Q, Zhou F, Wang X
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jun;34(6):108299
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jun;34(6):108299
Carnosol mitigates Ang II-stimulated vascular injury and oxidative stress by directly binding to FAK and inhibiting its activation.
Jiang Y, Zheng Z, Wang J, Liao Y, Jia Z, Lin W, Xu D, Wang J, Wu G, Liang G, Ye B
Inflammopharmacology 2025 Jun;33(6):3349-3362
Inflammopharmacology 2025 Jun;33(6):3349-3362
Gastrodia elata polysaccharide alleviates depression via gut microbiota modulation and Keap1-Nrf2/BDNF-TrkB pathway activation.
Wen M, Liu M, Zhang Y, Qiao B, Luo T, Liu G, Li D, Zhou B
International journal of biological macromolecules 2025 Jun;317(Pt 1):144630
International journal of biological macromolecules 2025 Jun;317(Pt 1):144630
Sanghuangporus vaninii polysaccharides alleviates the effects of chlorpyrifos exposure on mouse liver: role of the gut- liver axis.
Liu J, Sun L, Tang Y, Li J, Chen W, Geng J, Zong Y, He Z, Du R
International journal of biological macromolecules 2025 Jun;315(Pt 1):144504
International journal of biological macromolecules 2025 Jun;315(Pt 1):144504
Polygonatum cyrtonema polysaccharide alleviates dopaminergic neuron apoptosis in Parkinson's disease mouse model via inhibiting oxidative stress and endoplasmic reticulum stress.
Li QM, Xu H, Zha XQ, Zhang FY, Luo JP
International journal of biological macromolecules 2025 Jun;311(Pt 3):143986
International journal of biological macromolecules 2025 Jun;311(Pt 3):143986
Nrf2-and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic β-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice.
Yamada Y, Urakawa N, Tamiya H, Sakamoto S, Takahashi H, Harada N, Kitakaze T, Izawa T, Matsumua S, Yoshihara E, Inui H, Mashimo T, Yamaji R
The Journal of biological chemistry 2025 Jun;301(6):110271
The Journal of biological chemistry 2025 Jun;301(6):110271
Suppression of NRF2 by photodynamic action to enhance bortezomib-triggered DNA damage for synergistic colorectal cancer therapy.
Li LG, Chen H, Yu TT, Liu RL, Kong C, Leng F, Xiao RC, Lu YH, Han N, Hu J, Hui YJ, Li TF
Journal of photochemistry and photobiology. B, Biology 2025 Jun;267:113162
Journal of photochemistry and photobiology. B, Biology 2025 Jun;267:113162
Bilateral Synergistic Effects of Phototherapy-Based NIR-II Absorption Photosensitizer for Allergic Rhinitis.
Shao T, Han L, Xie Y, Shi Z, Yang Q, Liu A, Liu Y, Chen L, Huang J, Peng B, Bai H, Chen H, Li L, Bian K
Small (Weinheim an der Bergstrasse, Germany) 2025 Jun;21(22):e2412249
Small (Weinheim an der Bergstrasse, Germany) 2025 Jun;21(22):e2412249
Liposome of Phlorizin promote the repair of carotid atherosclerosis in rats by regulating inflammation and the Nrf2 signaling pathway.
Wu X, Ding C, Liu X, Ding Q, Zhang S, Wang Y, Zhao T, Liu W
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159613
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159613
Myeloid-specific deficiency of group VIA calcium-independent phospholipase A2 preconditions myeloid cells for injury resolution after acetaminophen exposure.
Xu F, Jansakun C, Li G, Biswas U, Poschet G, Staffer S, Tuma-Kellner S, Nakchbandi I, Merle U, Chamulitrat W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jun;187:118146
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jun;187:118146
Methyleugenol alleviates pulmonary vascular remodeling in rats with high-altitude pulmonary hypertension by improving pulmonary smooth muscle cell function.
Yu Y, Wang Y, Yang Z, Li Z, Lu D, Nan X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jun;187:118109
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jun;187:118109
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
Gan X, Li J, Jiang Y, Wang X, Zeng Y, Chen X, Huang H, Min J, Li G, Nie M, Kang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
Reprogramming Glucose Metabolism of Macrophage for Acute Liver Failure Therapy with Itaconate Lipo-Nanodrug.
Qiu C, Zhang W, Zhao Y, Han T, Yang W, Liu Y, Jin P, Chen J, Shuai X, Ren J, Huang P
Advanced healthcare materials 2025 Jun;14(15):e2500019
Advanced healthcare materials 2025 Jun;14(15):e2500019
Influence of α-Linolenic Acid on the Intestinal Barrier Integrity and Intestinal Antioxidant Status in Broilers.
Kang A, Ni J, Cheng X, Wu S, Liu Y, Ma W, Wang D
Food science & nutrition 2025 Jun;13(6):e70271
Food science & nutrition 2025 Jun;13(6):e70271
Flotillin- 1 ameliorates experimental diabetic retinopathy by inhibiting ferroptosis in blood-retinal barrier.
Zhang J, Chang K, Shangguan Y, Luo R, Bi Y, Yu Z, Li B
Journal of molecular medicine (Berlin, Germany) 2025 Jun;103(6):671-685
Journal of molecular medicine (Berlin, Germany) 2025 Jun;103(6):671-685
Antitumor/anti-inflammatory effects/tissue healing as an all-in-one therapeutic strategy for nasopharyngeal carcinoma.
Ni F, Lv H, Lin L, Zhang Y, Qiao Y, Zhang X, Li Z, Wang X, Dai X, Dong J
Journal of nanobiotechnology 2025 Jun 9;23(1):431
Journal of nanobiotechnology 2025 Jun 9;23(1):431
OTUB1-SLC7A11 Axis Mediates 4-Octyl Itaconate Protection Against Acetaminophen-Induced Ferroptotic Liver Injury.
Hu Z, Li Y, Xu D, Meng H, Liu W, Xu Q, Yao B, Wang J
Antioxidants (Basel, Switzerland) 2025 Jun 9;14(6)
Antioxidants (Basel, Switzerland) 2025 Jun 9;14(6)
Pterostilbene Reduces Cyclophosphamide-Induced Interstitial Cystitis by Facilitating Nrf2 Activation and Suppressing the NLRP3 Inflammasome Pathway.
Zhang J, Wang J, Wang X, Yan Z, Meng L, Zhang Y
International journal of molecular sciences 2025 Jun 8;26(12)
International journal of molecular sciences 2025 Jun 8;26(12)
Oligo-peptide I-C-F-6 mitigates polymicrobial sepsis-induced cardiac dysfunction in mice.
Li H, Li G, Gao Y, Ma Y, Yu Z, Zhang A, Yang G, Hou Z, Zhang Y, Yu Y, Zhang Z
European journal of pharmacology 2025 Jun 5;996:177545
European journal of pharmacology 2025 Jun 5;996:177545
Sesamin improved growth and overall health in young animals by enhancing gut-liver axis function.
Chen C, Qi M, Xu Z, Wen J, Tang W, Diao H, Li Z, Chu Y, Feng F, Tang Z
Food & function 2025 Jun 3;16(11):4415-4436
Food & function 2025 Jun 3;16(11):4415-4436
Piezo1 disrupts blood-brain barrier via CaMKII/Nrf2 in ischemic stroke.
Fu H, Yu Y, Wang S, Xu P, Sun Y, Li J, Ge X, Pan S
Cellular and molecular life sciences : CMLS 2025 Jun 28;82(1):259
Cellular and molecular life sciences : CMLS 2025 Jun 28;82(1):259
MYC promotes group 3 medulloblastoma cell proliferation and alleviates ROS-induced cell death by upregulating transketolase.
Wang S, Zhang D, Wang C, Liu Y
Acta neuropathologica communications 2025 Jun 28;13(1):139
Acta neuropathologica communications 2025 Jun 28;13(1):139
Molecular mechanisms of Potentilla Discolor Bunge in regulating ferroptosis to alleviate DKD via the Nrf2 signaling pathway.
Liu Y, Cai Y, Wei X, Gao K, Jin G, Zhou X, Zhao Z
Journal of ethnopharmacology 2025 Jun 26;350:120035
Journal of ethnopharmacology 2025 Jun 26;350:120035
Mechanisms of Cisplatin-Induced Acute Kidney Injury: The Role of NRF2 in Mitochondrial Dysfunction and Metabolic Reprogramming.
Liu J, Wang Y, Qiao P, Ying Y, Lin S, Lu F, Gao C, Li M, Yang B, Zhou H
Antioxidants (Basel, Switzerland) 2025 Jun 24;14(7)
Antioxidants (Basel, Switzerland) 2025 Jun 24;14(7)
Endothelial cell Nrf2 controls neuroinflammation following a systemic insult.
Zou H, Leah T, Huang Z, He X, Mameli E, Caporali A, Dando O, Qiu J
iScience 2025 Jun 20;28(6):112630
iScience 2025 Jun 20;28(6):112630
Computational design of diverse nuclear factor erythroid 2 activators with cellular antioxidative activity.
Yuwen M, Gao X, Ba J, Wu J, Kang J, Ye S, Zhu C
iScience 2025 Jun 20;28(6):112621
iScience 2025 Jun 20;28(6):112621
Pretreatment with Citrus reticulata 'Chachi' Polysaccharide Alleviates Alcohol-Induced Gastric Ulcer by Inhibiting NLRP3/ASC/Caspase-1 and Nrf2/HO-1 Signaling Pathways.
Liang H, Liang Y, Wu L, Lin L, Yao Y, Deng J, Xu J, Li H, Gao F, Xing W, Yu M, Jia X, Wei M, Li C, Zheng G
Nutrients 2025 Jun 20;17(13)
Nutrients 2025 Jun 20;17(13)
Identification of CD84 as a potent survival factor in acute myeloid leukemia.
Zhu Y, Murtadha M, Liu M, Caserta E, Napolitano O, Nguyen LXT, Wang H, Moloudizargari M, Nigam L, Tandoh T, Wang X, Pozhitkov A, Su R, Lin X, Estepa MD, Pillai R, Song J, Sanchez JF, Fu YH, Zhang L, Li M, Zhang B, Li L, Kuo YH, Rosen S, Marcucci G, Williams JC, Pichiorri F
The Journal of clinical investigation 2025 Jun 2;135(11)
The Journal of clinical investigation 2025 Jun 2;135(11)
Idebenone Orchestrates Anti-Inflammatory and Antioxidant Responses to Alleviate Brain Injury After Intracerebral Hemorrhage in Mice.
Chen C, Cao L, Xue M, Zhu N
Journal of integrative neuroscience 2025 Jun 19;24(6):37182
Journal of integrative neuroscience 2025 Jun 19;24(6):37182
Mechanisms of Aletris spicata (Thunb.) Franch. Extract in Asthma Therapy: Oxidative Stress, Inflammation, and Gut Microbiota.
Yang J, Chen Z, Zhu Y, Chen T, Zhou Y, Wang Z
Biology 2025 Jun 19;14(6)
Biology 2025 Jun 19;14(6)
NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia.
Hu J, Yuan Z, Shu Y, Ren J, Yang J, Tang L, Wei X, Liu Y, Jin F, Xiao Q, Chen X, Wu N, Zhao W, Li Z, Zhang L
Cancer & metabolism 2025 Jun 18;13(1):32
Cancer & metabolism 2025 Jun 18;13(1):32
Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice.
Lu T, Liu H, Yuan X, Li D, Zhang G, Wang Y, Xie Q, Wang X, Chi J, Wang Z, Wang S, Gao Y, Zhou L, Xu M
Ecotoxicology and environmental safety 2025 Jun 15;298:118330
Ecotoxicology and environmental safety 2025 Jun 15;298:118330
ANXA1 inhibits trophoblast ferroptosis in preeclampsia by downregulating KISS1†.
Rao Y, Tan S, Wang J, Jia J, Cai Z, Wu C, Wu P, Wang Z
Biology of reproduction 2025 Jun 15;112(6):1256-1272
Biology of reproduction 2025 Jun 15;112(6):1256-1272
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of velvet antler in the treatment of chronic atrophic gastritis.
Liao Q, Guo Z, Ding C, Zuo R, Liu G
Journal of food and drug analysis 2025 Jun 13;33(2):119-131
Journal of food and drug analysis 2025 Jun 13;33(2):119-131
Overexpression of the circadian gene Bmal1 regulates the Nrf2/HO-1 oxidative stress pathway to alleviate inflammation and apoptosis in PC12 cells following cerebral ischemia-reperfusion injury.
Zeng F, Wang M, Li Z, Zhang Y
Medicine 2025 Jun 13;104(24):e42763
Medicine 2025 Jun 13;104(24):e42763
Protective Effects of Fish Oil Against Brain Impairment in Rats with Chronic Ethanol-Induced Liver Damage Involving the NRF2 Pathway and Oxidative Stress.
Xiao Q, Chen YH, Fu LC, Nurrahma HA, Lai JH, Shirakawa H, Yang SC
Antioxidants (Basel, Switzerland) 2025 Jun 10;14(6)
Antioxidants (Basel, Switzerland) 2025 Jun 10;14(6)
Antioxidant interventions reduced cytokine-induced pyroptosis of peripheral MAIT cells in patients with HBV-related cirrhosis.
Xu Z, Xu Z, Fan X, Qu MM, Wang H, Li J, Gao L, Jiao YM, Shi J, Wang FS
Hepatology communications 2025 Jun 1;9(6)
Hepatology communications 2025 Jun 1;9(6)
Activation of TFEB protects against diabetic vascular calcification by improving autophagic flux and activating Nrf2 antioxidant system.
Sun XJ, Xiao SJ, Ma WQ, Jin H, Ren LQ, Yao YY, Chen ZD, Li XX, Chen T, Liu NF
American journal of physiology. Endocrinology and metabolism 2025 Jun 1;328(6):E924-E939
American journal of physiology. Endocrinology and metabolism 2025 Jun 1;328(6):E924-E939
Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.
Li Q, Huang Y, Ban T, Chen K, Zhen X, Dai Q, Zhang G
Neuropharmacology 2025 Jun 1;270:110374
Neuropharmacology 2025 Jun 1;270:110374
Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2.
Jiang Z, Liu D, Li T, Gai C, Xin D, Zhao Y, Song Y, Cheng Y, Li T, Wang Z
Neural regeneration research 2025 Jun 1;20(6):1776-1788
Neural regeneration research 2025 Jun 1;20(6):1776-1788
Isomeric 2-isobutylmalate derivatives with anti-pulmonary fibrosis effects from the leaves of Bletilla striata via LC-MS/MS-based molecular networking.
Zhou M, Liu S, Yuan F, Li J, Zhou M, Huang J, Zhang Y, Liang Q
Bioorganic chemistry 2025 Jun 1;159:108351
Bioorganic chemistry 2025 Jun 1;159:108351
Autophagy hub-protein p62 orchestrates oxidative, endoplasmic reticulum stress, and inflammatory responses post-ischemia, exacerbating stroke outcome.
Quan X, Yang Y, Liu X, Kaltwasser B, Pillath-Eilers M, Walkenfort B, Voortmann S, Mohamud Yusuf A, Hagemann N, Wang C, Hasenberg M, Hermann DM, Brockmeier U
Redox biology 2025 Jul;84:103700
Redox biology 2025 Jul;84:103700
Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4-regulated ferroptosis.
Wen SY, Gao RR, Chen YY, Wang YJ, Wang XT, Liu HX
Animal models and experimental medicine 2025 Jul;8(7):1155-1165
Animal models and experimental medicine 2025 Jul;8(7):1155-1165
Aerobic Exercise Activates Fibroblast Growth Factor 21 and Alleviates Cardiac Ischemia/Reperfusion-induced Neuronal Oxidative Stress and Ferroptosis in Paraventricular Nucleus.
Zhao Y, Feng L, Wu C, Xu Y, Bo W, Di L, Pan S, Cai M, Tian Z
Molecular neurobiology 2025 Jul;62(7):8484-8501
Molecular neurobiology 2025 Jul;62(7):8484-8501
Activation of the Nrf2 Signaling Pathway by Tetrahydroberberine Suppresses Ferroptosis and Enhances Functional Recovery Following Spinal Cord Injury.
Li X, Yu H, Liu R, Miao J, Lv J, Yang S, Zhu Y, Chen Y, Lu K, Huang C, Wang X
Molecular neurobiology 2025 Jul;62(7):8439-8456
Molecular neurobiology 2025 Jul;62(7):8439-8456
Ethanol-induced Nrf2 suppression in the lung is mediated by AP-1-driven expression of miR-144.
Sueblinvong V, Fan X, Guo J, Tao H, Guidot DM
Alcohol, clinical & experimental research 2025 Jul;49(7):1424-1434
Alcohol, clinical & experimental research 2025 Jul;49(7):1424-1434
FNDC5/Irisin exacerbates APAP-induced acute liver injury through activating JNK/NF-κB and inflammatory response.
Zhang QH, Jin LM, Lin MS, Wang MX, Cui YQ, Ye JX, Xiong YQ, Luo W, Zhu WW, Liang G
Acta pharmacologica Sinica 2025 Jul;46(7):1946-1957
Acta pharmacologica Sinica 2025 Jul;46(7):1946-1957
GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Attenuates Skeletal Muscle Abnormalities in a Murine Model of Duchenne Muscular Dystrophy.
Myszka M, Jakubczak E, Mucha O, Hajok K, Waśniowska U, Nalepa A, Dulak J, Łoboda A
Antioxidants & redox signaling 2025 Jul;43(1-3):115-137
Antioxidants & redox signaling 2025 Jul;43(1-3):115-137
Methacrylated sericin/methacrylated hyaluronic acid composite microneedles with exosomes for diabetic wound healing.
Xu X, Shen Y, Wu J, Hong F, Xia H, Chen X, Lin G, Liu L, Xu RA
International journal of biological macromolecules 2025 Jul;318(Pt 1):144957
International journal of biological macromolecules 2025 Jul;318(Pt 1):144957
KEAP1 retention in phase-separated p62 bodies drives liver damage under autophagy-deficient conditions.
Takada S, Shinomiya N, Mao G, Tsuchiya H, Koga T, Komatsu-Hirota S, Sou YS, Abe M, Ryzhii E, Suzuki M, Nakao M, Waguri S, Morishita H, Komatsu M
EMBO reports 2025 Jul;26(13):3384-3410
EMBO reports 2025 Jul;26(13):3384-3410
Coriander-Derived Exosome-Like Nanovesicles Laden Hydrogel with Antioxidant Property Accelerates Wound Healing.
Wang T, Li Y, Hao L, Liu Y, Liu D, Zhang C, Yi H, Zhang J
Macromolecular bioscience 2025 Jul;25(7):e2400640
Macromolecular bioscience 2025 Jul;25(7):e2400640
Soyasaponin Bb Attenuates Morphine Withdrawal-Induced Anxiety-Like Behaviors in Male Mice by Rescuing GSK-3β/Nrf2 Signaling.
Wu J, Zhu C, Shu Y, Lu Y, Liu L, Xiao Z, Li Z
Psychiatry investigation 2025 Jul;22(7):821-831
Psychiatry investigation 2025 Jul;22(7):821-831
Lead (Pb) Induces Osteotoxicity Through the Activation of Mutually Reinforced ER Stress and ROS in MC3T3-E1 Cells.
Xie S, Yin M, Xiang M, Shao L, Zhang N, Shi L, Zhang J, Yu G
Biological trace element research 2025 Jul;203(7):3820-3832
Biological trace element research 2025 Jul;203(7):3820-3832
NRF2 modulates WNT signaling pathway to enhance photodynamic therapy resistance in oral leukoplakia.
Xu T, Zhong L, Liu Q, Wang F, Kuang W, Liang J, Yang D, Zhou X, Dan H, Zhao H, Li T, Zeng X, Li J, Chen Q
EMBO molecular medicine 2025 Jul;17(7):1794-1824
EMBO molecular medicine 2025 Jul;17(7):1794-1824
Fucoxanthin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Mice via Nrf2/HO-1/GPX4-Mediated Ferroptosis Pathway.
Liu Z, Ye J, Xi J, Li Q, Tang Y, Tian Y, Wang D, Yang Z, Ding Y
Food science & nutrition 2025 Jul;13(7):e70589
Food science & nutrition 2025 Jul;13(7):e70589
Loss of WDR23 slows the rate of age-related cognitive decline with elevated amyloid burden.
Liu J, Duangjan C, Phan NM, Curran SP
Journal of Alzheimer's disease : JAD 2025 Jul;106(1):218-229
Journal of Alzheimer's disease : JAD 2025 Jul;106(1):218-229
Exploring the Protective Effect and Regulatory Mechanism of Plumbagin on Renal Ischemia-Reperfusion Injury Based on the Nrf-2/HO-1 Signaling Pathway.
Luo Q, Zhu Z, Wan L
Transplantation proceedings 2025 Jul-Aug;57(6):1180-1186
Transplantation proceedings 2025 Jul-Aug;57(6):1180-1186
Interleukin-22 ameliorates alcohol-associated liver fibrosis via Nrf2-ARE signaling: mechanistic insights and clinical correlations.
Xu X, Zhao H, Zhang J, Yan H, Liu X, Huo J, Huo L
Clinics and research in hepatology and gastroenterology 2025 Jul-Aug;49(7):102617
Clinics and research in hepatology and gastroenterology 2025 Jul-Aug;49(7):102617
Dermal papilla cells-conditioned medium attenuates oxidative stress-induced senescence via ferroptosis inhibition.
Ru Z, Wu Y, Qu Q, Miao Y, Zhu L, Hu Z
Scientific reports 2025 Jul 9;15(1):24789
Scientific reports 2025 Jul 9;15(1):24789
Dihydromyricetin attenuates intervertebral disc degeneration by inhibiting NLRP3 inflammasome activation via the Keap1/Nrf2/HO-1 pathway.
Hong H, Guo D, Xia T, Zhang Y
European journal of pharmacology 2025 Jul 5;998:177501
European journal of pharmacology 2025 Jul 5;998:177501
Fluorinated sulfonamide-flavonoid derivatives as novel Keap1-Nrf2 inhibitors: Potent induction of cytoprotective gene HO-1 in vivo.
Sang Y, Huang W, Lin J, Yang L, Zhou Y, Yu C, Sun X, Yu H, Kong X
European journal of medicinal chemistry 2025 Jul 5;291:117650
European journal of medicinal chemistry 2025 Jul 5;291:117650
Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke.
Bai L, Li N, Li H, Dai Y, Bai Y, Ma F, Sha D, Xia S, Xu Y, Cao X
Journal of nanobiotechnology 2025 Jul 5;23(1):488
Journal of nanobiotechnology 2025 Jul 5;23(1):488
Galangin Regulates Oxidative Stress Levels in Porcine Embryos Through Interaction with the Neh1 Domain of Nrf2.
Chi ZC, Shi SM, Liu LY, Qu LY, Li JH, Jia GL, He YY, Li LX, Jin YX, Zhang MJ, Yu XF
Antioxidants (Basel, Switzerland) 2025 Jul 4;14(7)
Antioxidants (Basel, Switzerland) 2025 Jul 4;14(7)
Melatonin modulates mitochondrial function and inhibits atherosclerosis progression through NRF2 activation and OPA1 inhibition.
Lu C, Lin Q, Guo X, Luo T, Zhou H, Cai Z, Peng C, Yang G, Wang W
International immunopharmacology 2025 Jul 28;160:114960
International immunopharmacology 2025 Jul 28;160:114960
Cadmium Inhibits Proliferation of Human Bronchial Epithelial BEAS-2B Cells Through Inducing Ferroptosis via Targeted Regulation of the Nrf2/SLC7A11/GPX4 Pathway.
Li H, Qiu Z, Chen L, Zhang T, Wei D, Chen X, Wang Y
International journal of molecular sciences 2025 Jul 25;26(15)
International journal of molecular sciences 2025 Jul 25;26(15)
DNA damage response pathway regulates Nrf2 in response to oxidative stress.
Jiang XY, Guo QQ, Wang SS, Guo R, Zou Y, Liu JW, Feng YL, Guo Y, Li YH, Liu XY, Zhang XY, Hao S, Wu XX, Li MH, Liu A, Li CL, Guo WD, Xu HD, Song XY, Finkel T, Cao L
Science advances 2025 Jul 25;11(30):eadu9555
Science advances 2025 Jul 25;11(30):eadu9555
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Sun S, Qiu H, Wang C, Zhang K, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2025 Jul 24;351:120149
Journal of ethnopharmacology 2025 Jul 24;351:120149
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
Liu L, Ma Y, Jian Z, Liao B, Li Y, Lin L, Wang M, Chen J, Wei J, Yang M, Liu Y, Yuan Y, Wen J, Xiang L, Qi S, Jin X, Wang K
Cell reports 2025 Jul 22;44(7):115936
Cell reports 2025 Jul 22;44(7):115936
Combination of astragalus polysaccharide with Diosbulbin B exerts an enhanced antitumor effect in BRAF(mut) papillary thyroid cancer with decreased liver toxicity.
Xu S, Liang Q, Li H, Zhou H, Xu Z, Yan Y, Zhang Y, Ye R, You X
Cancer cell international 2025 Jul 2;25(1):245
Cancer cell international 2025 Jul 2;25(1):245
High-Fat Diet-Induced Diabetic Cardiomyopathy in Female Zebrafish: Cardiac Pathology and Functional Decline Mediated by Type 2 Diabetes.
Huang S, Chen Z, Li H, Zou Y, Wang B, Zhao W, Zheng L, Zhou Z, Peng X, Tang C
Nutrients 2025 Jul 2;17(13)
Nutrients 2025 Jul 2;17(13)
Uridine alleviates the aging of alveolar epithelial cells in idiopathic pulmonary fibrosis through the Keap1-Nrf2 signaling pathway.
Ding C, Zuo R, Liao Q, Guo Z, He J, Ye Z, Liu G
Scientific reports 2025 Jul 2;15(1):22952
Scientific reports 2025 Jul 2;15(1):22952
Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes' expression and upregulating Nrf2/Heme oxygenase-1.
Mahran Y, Badr AM, Aloyouni S, Alkahtani MM, Sarawi WS, Ali R, Alsultan D, Almufadhili S, Almasud DH, Hasan IH
Scientific reports 2025 Jul 2;15(1):22720
Scientific reports 2025 Jul 2;15(1):22720
Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization.
Gao Y, Zhou R, Lin X, Liu Z, Su Y, Lian H, Lin B, Ding X, Liao S, Li X, Zhao J, Xu J, Xu R, Liu Q, Song F
Journal of translational medicine 2025 Jul 18;23(1):805
Journal of translational medicine 2025 Jul 18;23(1):805
Strengthening monocarboxylate transporters by adiponectin receptor agonist ameliorates diabetic peripheral neuropathy.
Kim TW, Oum SJ, Lim JH, Kim Y, Kim EN, Jin Y, Hong YA, Chae SY, Choi BS, Kim HW, Park CW
Cell communication and signaling : CCS 2025 Jul 16;23(1):342
Cell communication and signaling : CCS 2025 Jul 16;23(1):342
S-COS-Se mitigates cadmium-induced oxidative stress, inflammation, and immunotoxicity by restoring immune balance and inhibiting mitochondria-pyroptosis crosstalk.
Zheng H, Dong W, Qiu H, Gao S, Hou L, Dong J, Zhao P, Chen F
Ecotoxicology and environmental safety 2025 Jul 15;300:118462
Ecotoxicology and environmental safety 2025 Jul 15;300:118462
Biochemical Insights into the Effects of a Small Molecule Drug Candidate on Imatinib-Induced Cardiac Inflammation.
Szabó R, Börzsei D, Nagy A, Kiss V, Virág Z, Kis G, Almási N, Török S, Veszelka M, Bagyánszki M, Bódi N, Barta BP, Neuperger P, Szebeni GJ, Varga C
International journal of molecular sciences 2025 Jul 11;26(14)
International journal of molecular sciences 2025 Jul 11;26(14)
Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.
Zhang S, Tang F, Zhou Z, Li L, Tang Y, Fu K, Tan Y, Li L
International journal of molecular sciences 2025 Jul 11;26(14)
International journal of molecular sciences 2025 Jul 11;26(14)
Irisin prevents liver injury during exhausting physical activity by suppressing ferroptosis via Nrf2/GPX4 signaling.
Li Z, Wang B, Li X
BMC gastroenterology 2025 Jul 11;25(1):516
BMC gastroenterology 2025 Jul 11;25(1):516
Effects of solamargine in hepatic metastasis of colorectal cancer: induction of ferroptosis and elimination of cancer stem cells.
Liu S, Wu J, Huang H, Hu B, Xie D, Cao F, Li J, Guo C, Peng W, Jin Y, Dai W
Chinese medicine 2025 Jul 11;20(1):110
Chinese medicine 2025 Jul 11;20(1):110
cDTL contributes to breast cancer progression through regulating redox homeostasis via affecting the function of system xc().
Wang S, Liu L, Li X, Li Q, Wang Y, Feng X
Biochemical and biophysical research communications 2025 Jan;744:151196
Biochemical and biophysical research communications 2025 Jan;744:151196
Sulforaphane, Urolithin A, and ZLN005 induce time-dependent alterations in antioxidant capacity, mitophagy, and mitochondrial biogenesis in muscle cells.
Moradi N, Champsi S, Hood DA
Sports medicine and health science 2025 Jan;7(1):16-27
Sports medicine and health science 2025 Jan;7(1):16-27
AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis.
Xiong C, Ling H, Huang Y, Dong H, Xie B, Hao Q, Zhou X
Science China. Life sciences 2025 Jan;68(1):204-218
Science China. Life sciences 2025 Jan;68(1):204-218
Shionone Inhibits Glomerular Fibirosis by Suppressing NLRP3 Related Inflammasome though SESN2-NRF2/ HO-1 Pathway.
Xiao T, Zhao H, Wang Y, Chen M, Wang C, Qiao C
Diabetes & metabolism journal 2025 Jan;49(1):34-48
Diabetes & metabolism journal 2025 Jan;49(1):34-48
NEK2 affects the ferroptosis sensitivity of gastric cancer cells by regulating the expression of HMOX1 through Keap1/Nrf2.
Wu J, Luo D, Tou L, Xu H, Jiang C, Wu D, Que H, Zheng J
Molecular and cellular biochemistry 2025 Jan;480(1):425-437
Molecular and cellular biochemistry 2025 Jan;480(1):425-437
MMP-9 responsive hydrogel promotes diabetic wound healing by suppressing ferroptosis of endothelial cells.
Lin C, Hu Y, Lin Z, Du L, Hu Y, Ouyang L, Xie X, Cheng P, Liao J, Lu L, Zeng R, Xia P, Hou Z, Liu G, Hu H
Bioactive materials 2025 Jan;43:240-254
Bioactive materials 2025 Jan;43:240-254
Gypenoside XLIX alleviates sepsis-associated encephalopathy by targeting PPAR-α.
Zhao P, Zhang W, Zhou X, Zhao Y, Li A, Sun Y
Experimental neurology 2025 Jan;383:115027
Experimental neurology 2025 Jan;383:115027
Dopamine receptor agonist pramipexole exerts neuroprotection on global cerebral ischemia/reperfusion injury by inhibiting ferroptosis.
Kang X, Wang W, Zuo Y, Wang Y, Zhang L, Liu L
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jan;34(1):108101
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jan;34(1):108101
Astroglial membrane camouflaged Ptbp1 siRNA delivery hinders glutamate homeostasis via SDH/Nrf2 pathway.
Liu Y, Ren J, Zhang W, Ding L, Ma R, Zhang M, Zheng S, Liang R, Zhang Y
Biomaterials 2025 Jan;312:122707
Biomaterials 2025 Jan;312:122707
Structural characterization and in vitro hepatoprotective activity of an acidic polysaccharide from Dendrobium nobile Lindl. flower.
Li Y, Duan X, Wang Y, Deng Y, Zhang J
International journal of biological macromolecules 2025 Jan;284(Pt 1):138100
International journal of biological macromolecules 2025 Jan;284(Pt 1):138100
Oxidative stress levels and antioxidant defense mechanisms (Nrf2-Keap1 signaling pathway) in the Harderian glands of hibernating Daurian ground squirrels.
Wang Z, Li LF, Yan YJ, Huang JY, Xi YF, Yuan MY, Dong JY, Wang MD, Dang K
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2025 Jan;275:111044
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2025 Jan;275:111044
Scopoletin ameliorates hyperlipidemia and hepatic steatosis via AMPK, Nrf2/HO-1 and NF-κB signaling pathways.
Zhang J, Yuan Y, Gao X, Li H, Yuan F, Wu D, Cui Q, Piao G, Yuan H
Biochemical pharmacology 2025 Jan;231:116639
Biochemical pharmacology 2025 Jan;231:116639
LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction.
Fan L, Guo D, Zhu C, Gao C, Wang Y, Yin F, Liu M, Zhou Y, Wei T, Xiong X, Yu K, Le A
Free radical biology & medicine 2025 Jan;226:29-42
Free radical biology & medicine 2025 Jan;226:29-42
Resveratrol alleviates depression-like behaviors by inhibiting ferroptosis via AKT/NRF2 pathway.
Li C, Ge H, Huang J, Si L, Sun L, Wu L, Xiao L, Xie Y, Wang G
Brain research bulletin 2025 Jan;220:111136
Brain research bulletin 2025 Jan;220:111136
Ingenane diterpenoids with anti-inflammatory activity from Euphorbia antiquorum.
Ma RF, Wu Q, Pan YP, Liu H, Zhuang XC, Zhang H
Fitoterapia 2025 Jan;180:106350
Fitoterapia 2025 Jan;180:106350
Adipose tissue macrophages-derived exosomal MiR-500a-5p under high glucose promotes adipocytes inflammation by suppressing Nrf2 expression.
Li YZ, Tian Y, Yang C, Liu YF, Qu SL, Huang L, Zhang C
The international journal of biochemistry & cell biology 2025 Jan;178:106713
The international journal of biochemistry & cell biology 2025 Jan;178:106713
1,25-Dihydroxyvitamin D(3) protects against placental inflammation by suppressing NLRP3-mediated IL-1β production via Nrf2 signaling pathway in preeclampsia.
Liu X, Zhang X, Ma L, Qiang N, Wang J, Huang Y, Yuan X, Lu C, Cao Y, Xu J
Metabolism: clinical and experimental 2025 Jan;162:156058
Metabolism: clinical and experimental 2025 Jan;162:156058
Perillaldehyde pretreatment alleviates cerebral ischemia-reperfusion injury by improving mitochondrial structure and function via the Nrf2/Keap1/Trx2 axis.
Liu J, Han Y, Wu Z, Chen M, Wu W, Zhao Z, Yuan J, Zheng Z, Lin Q, Liu N, Chen H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156328
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156328
Psoralen and Isopsoralen Activate Nuclear Factor Erythroid 2-Related Factor 2 Through Interaction With Kelch-Like ECH-Associated Protein 1.
Lv C, Wang S, Sun C, Liu J, Chen Y, Wang C, Yuan C, Qin F, Li T
Food science & nutrition 2025 Jan;13(1):e4768
Food science & nutrition 2025 Jan;13(1):e4768
Reduction of Chemoresistance by Claudin-14-Targeting Peptide in Human Colorectal Cancer Cells.
Mizukami Y, Hashimoto S, Ando T, Ishikawa Y, Eguchi H, Yoshino Y, Matsunaga T, Matsuhashi N, Ikari A
Journal of cellular biochemistry 2025 Jan;126(1):e30675
Journal of cellular biochemistry 2025 Jan;126(1):e30675
TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis.
Qiu C, Cheng L, Di D, Xiang Z, Wang C, Li J, Xiong Y, Li M, Liu J, Zhou J, Liu T, Wang X, Luo D, Wang X, Li S, Wang H, Wang X, Zhao Y, Liu X, Wang L
Genes & diseases 2025 Jan;12(1):101251
Genes & diseases 2025 Jan;12(1):101251
Effect of different dietary oil sources on the performance, egg quality and antioxidant capacity during the late laying period.
Xu M, Liu L, Fan Z, Niu L, Ning W, Cheng H, Li M, Huo W, Zhou P, Deng H, Chen W, Che L
Poultry science 2025 Jan;104(1):104615
Poultry science 2025 Jan;104(1):104615
Protective Effects of α-Linolenic Acid on Liver Inflammation and Oxidative Stress Induced by Lipopolysaccharide in Broilers.
Cheng X, Zhang X, Ni J, Ding H, Ma W, Wang D
Animal science journal = Nihon chikusan Gakkaiho 2025 Jan-Dec;96(1):e70096
Animal science journal = Nihon chikusan Gakkaiho 2025 Jan-Dec;96(1):e70096
Mechanism of triiodothyronine alleviating acute alcoholic liver injury and delaying alcoholic liver fibrosis progression.
Luo R, Li S, Yang M, Wu J, Feng J, Sun Y, Zhao Y, Mao L
Human & experimental toxicology 2025 Jan-Dec;44:9603271251332505
Human & experimental toxicology 2025 Jan-Dec;44:9603271251332505
Pedunculoside inhibits cardiomyocyte inflammatory biomarkers via Nrf2/HO-1 pathway in high glucose-induced H9c2 cells and diabetic cardiomyopathy model rats.
Lu Y, Meng J, Zhu D, Jiang Z, Ma H
Human & experimental toxicology 2025 Jan-Dec;44:9603271251322186
Human & experimental toxicology 2025 Jan-Dec;44:9603271251322186
5-(3-(N-(Carboxymethyl)naphthalene-2-sulfonamido)phenyl)-1-ethyl-1H-pyrrole-2-carboxylic acid as a Keap1-Nrf2 inhibitor for cerebral ischemia/reperfusion injury treatment.
Cairang N, Wu Y, Zhi S, Tang J, Tie X, Zhan D, Lu G, Shi Y, Zhao Q
RSC advances 2025 Jan 9;15(2):1052-1059
RSC advances 2025 Jan 9;15(2):1052-1059
Melanin-Deferoxamine Nanoparticles Targeting Ferroptosis Mitigate Acute Kidney Injury via RONS Scavenging and Iron Ion Chelation.
Sun J, Shen H, Dong J, Zhang J, Yue T, Zhang R
ACS applied materials & interfaces 2025 Jan 8;17(1):282-296
ACS applied materials & interfaces 2025 Jan 8;17(1):282-296
Gegen Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting Nrf2.
Zhang X, Ji Z, He Q, Yang D, Wang X, Liu C, Zhang C, Yuan J, Xu N, Chu J
Journal of ethnopharmacology 2025 Jan 31;340:119290
Journal of ethnopharmacology 2025 Jan 31;340:119290
Saffron extract alleviates D-gal-induced late-onset hypogonadism by activating the PI3K-Akt-Nrf2 signaling pathway.
Liu H, Guo Z, Zang Z, Jia B, Zhou Y, Zhang H, Fu Q
Journal of ethnopharmacology 2025 Jan 31;340:119273
Journal of ethnopharmacology 2025 Jan 31;340:119273
Multi-platform analysis revealed the substance basis and mechanism of Wei-Tong-Xin in ameliorating ENS dysfunction for dyspepsia treatment.
Zhang X, Wang S, Xie J, Wang J, Gu Y, Wu B, Zhang Y, Yan T, Jia Y
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118875
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118875
Ethyl acetate fraction of Thesium chinense Turcz. alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis mediated by activating Nrf2/SLC7A11/GPX4 axis.
Liu MJ, Xu ZP, Guan YQ, Wang YY, Wen XS, Li GH, Wang XN, Shen T
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118776
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118776
Supplementation with carnosine, a food-derived bioactive dipeptide, alleviates dexamethasone-induced oxidative stress and bone impairment via the NRF2 signaling pathway.
Li XY, Gu XY, Li XM, Yan JG, Mao XL, Yu Q, Du YL, Kurihara H, Yan CY, Li WX
Journal of the science of food and agriculture 2025 Jan 30;105(2):1091-1104
Journal of the science of food and agriculture 2025 Jan 30;105(2):1091-1104
USP38 exacerbates myocardial injury and malignant ventricular arrhythmias after ischemia/reperfusion by promoting ferroptosis through the P53/SLC7A11 pathway.
Gong Y, Yang H, Chen T, Zhang J, Kong B, Shuai W, Huang H
International immunopharmacology 2025 Jan 3;145:113727
International immunopharmacology 2025 Jan 3;145:113727
Facile Formulation of a Resveratrol-Mediated Multibond Network Hydrogel with Efficient Sustainable Antibacterial, Reactive Oxygen Species Scavenging, Pro-Angiogenesis, and Immunomodulation Activities for Accelerating Infected Wound Healing.
Feng J, Wang Z, Li X, Bao C, Xiao Y
ACS applied materials & interfaces 2025 Jan 29;17(4):6144-6160
ACS applied materials & interfaces 2025 Jan 29;17(4):6144-6160
Solanum lycopersicum derived exosome-like nanovesicles alleviate restenosis after vascular injury through the Keap1/Nrf2 pathway.
Shen H, Zhang M, Liu D, Liang X, Chang Y, Hu X, Gao W
Food & function 2025 Jan 20;16(2):539-553
Food & function 2025 Jan 20;16(2):539-553
Comprehensive Pan-Cancer Analysis and Functional Studies Reveal SLC2A6 as a Ferroptosis Modulator in Hepatocellular carcinoma.
Yan G, Huang H, Lu Z, Chen M, Wang X, Zhong P, Qin C, Mo S, Han C, Luo X, Ye X
Scientific reports 2025 Jan 20;15(1):2545
Scientific reports 2025 Jan 20;15(1):2545
Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens.
Pan D, Hu G, Li J, Wang Z, Chen Y, Cao J
Investigative ophthalmology & visual science 2025 Jan 2;66(1):3
Investigative ophthalmology & visual science 2025 Jan 2;66(1):3
The therapeutic potential of Osmundacetone for rheumatoid arthritis: Effects and mechanisms on osteoclastogenesis.
Wang Z, Liu Y, Feng C, Li T, Xu H, Ding Y, Liu W, Pu L, Li R, Ai C, Chen Z, Wang X
European journal of pharmacology 2025 Jan 15;987:177135
European journal of pharmacology 2025 Jan 15;987:177135
Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms.
Zhang P, Zhou Z, Yao J, Jiang Y, Lei H, Xie Z, Li J, Zhao X, Zhu L, Wan M, Liu L, Tang W
Ecotoxicology and environmental safety 2025 Jan 15;290:117747
Ecotoxicology and environmental safety 2025 Jan 15;290:117747
Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice.
Liu M, Li Z, Li J, Yan G, Liu C, Yin Q, Liu Y, Xu X
Ecotoxicology and environmental safety 2025 Jan 15;290:117530
Ecotoxicology and environmental safety 2025 Jan 15;290:117530
Synthesis, evaluation and mechanism study of novel pyrazole enamides to alleviate lung injury.
Zhang G, Li M, Ou Y, Ma L, Li J, Sun K, Xia T, Wang J, Song L, Liu Y, Lin R, Yao H
European journal of medicinal chemistry 2025 Jan 15;282:117068
European journal of medicinal chemistry 2025 Jan 15;282:117068
The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.
Song Y, Zhu X, Wang B, Li Q, Song B
Scientific reports 2025 Jan 10;15(1):1614
Scientific reports 2025 Jan 10;15(1):1614
Mechanism of dihydroartemisinin in the treatment of ischaemia/reperfusion-induced acute kidney injury via network pharmacology, molecular dynamics simulation and experiments.
Jiang B, Liu J, Qu Z, Wang Y, Wang Y, Li Z, Jin X, Lao Y, He R, Yang S
International immunopharmacology 2025 Jan 10;144:113705
International immunopharmacology 2025 Jan 10;144:113705
Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies.
Yin L, He Z, Fan Y, Niu Z, Yao L, Ding S, Chen J, Zhang Q, Tong Y, Bi Q, Cao L
International immunopharmacology 2025 Jan 10;144:113695
International immunopharmacology 2025 Jan 10;144:113695
The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
Jiang Y, He P, Sheng K, Peng Y, Wu H, Qian S, Ji W, Guo X, Shan X
eLife 2025 Jan 10;13
eLife 2025 Jan 10;13
RNA m(6)A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells.
Zhang N, Yang J, Zhao Y, Li W, Zhao B, Li R, He Z, Gu S
Cell death discovery 2025 Jan 10;11(1):4
Cell death discovery 2025 Jan 10;11(1):4
Mechanism of P-Hydroxy Benzyl Alcohol Against Cerebral Ischemia Based on Metabonomics Analysis.
Xiao T, Yu X, Tao J, Tan J, Zhao Z, Zhang C, Duan X
International journal of molecular sciences 2025 Jan 1;26(1)
International journal of molecular sciences 2025 Jan 1;26(1)
Liraglutide and GLP-1(9-37) alleviated hepatic ischemia-reperfusion injury by inhibiting ferroptosis via GSK3β/Nrf2 pathway and SMAD159/Hepcidin/FTH pathway.
Lu C, Xu C, Li S, Ni H, Yang J
Redox biology 2025 Feb;79:103468
Redox biology 2025 Feb;79:103468
Loss of Urat1 exacerbates APAP-induced liver injury in mice.
Zhao K, Zhang S, Tian J, Wu S, Chen Y, Wu Z, Liang J, Wu H, Pang J, Wu T
Toxicology 2025 Feb;511:154070
Toxicology 2025 Feb;511:154070
Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.
Shi Y, Hong R, Fan Z, Huan R, Gao Y, Ma M, Liu T, Pan C
Toxicology 2025 Feb;511:154067
Toxicology 2025 Feb;511:154067
Artemisinin inhibits neuronal ferroptosis in Alzheimer's disease models by targeting KEAP1.
Deng PX, Silva M, Yang N, Wang Q, Meng X, Ye KQ, Gao HC, Zheng WH
Acta pharmacologica Sinica 2025 Feb;46(2):326-337
Acta pharmacologica Sinica 2025 Feb;46(2):326-337
Rejuvenation Modulation of Nucleus Pulposus Progenitor Cells Reverses Senescence-Associated Intervertebral Disc Degeneration.
Zhao DW, Zhang J, Chen C, Sun W, Liu Y, Han M, Zhang Y, Fu Z, Shi C, Zhao X, Yang Z, Tang C, Zhao K, Zhu D, Zhang Y, Cheng L, Jiang X
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(7):e2409979
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(7):e2409979
Polyphenol Mediated Assembly: Tailored Nano-Dredger Unblocks Axonal Autophagosomes Retrograde Transport Traffic Jam for Accelerated Alzheimer's Waste Clearance.
Meng R, Li Y, Yang X, Cheng Y, Xu M, Zhou L, Wu C, Yu S, Huang W, Wang T, Zhang Q
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(5):e2413614
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(5):e2413614
Anti-inflammatory effect of echinacoside in collagen-induced arthritis via Nrf2/Drp1 pathway.
Wang X, Li L, Zhang M, Ji R, Li N, Wang K, Chen Z
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2025 Feb;34(2):199-209
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2025 Feb;34(2):199-209
Ophiopogon japonicus polysaccharide reduces doxorubicin-induced myocardial ferroptosis injury by activating Nrf2/GPX4 signaling and alleviating iron accumulation.
Chen Y, Ma L, Yan Y, Wang X, Cao L, Li Y, Li M
Molecular medicine reports 2025 Feb;31(2)
Molecular medicine reports 2025 Feb;31(2)
Blockade of cysteinyl leukotriene receptor 1 alleviates asthma by inhibiting bronchial epithelial cell apoptosis and activating the Nrf2 signaling pathway.
Wu X, Chen Y, Chen S, Lin Y
Experimental and therapeutic medicine 2025 Feb;29(2):30
Experimental and therapeutic medicine 2025 Feb;29(2):30
Heat exposure promotes sarcopenia via gut microbiota-derived metabolites.
Guo YF, Liu ZY, Zhou M, Kuang WH, Liu Y, Huang Y, Yin P, Xia ZY
Aging cell 2025 Feb;24(2):e14370
Aging cell 2025 Feb;24(2):e14370
Stigmasterol from Prunella vulgaris L. Alleviates LPS-induced mammary gland injury by inhibiting inflammation and ferroptosis.
Sun M, Xu D, Liu D, Ran X, Li F, Wang J, Ge Y, Liu Y, Guo W, Liu J, Cao Y, Fu S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156362
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156362
Unraveling morphine tolerance: CCL2 induces spinal cord apoptosis via inhibition of Nrf2 signaling pathway and PGC-1α-mediated mitochondrial biogenesis.
Jie J, Jihao R, Zheng L, Jie L, Xiaoling P, Wei Z, Feng G
Brain, behavior, and immunity 2025 Feb;124:347-362
Brain, behavior, and immunity 2025 Feb;124:347-362
Engineered Bacillus subtilis WB600/ZD prevents Salmonella Infantis-induced intestinal inflammation and alters the colon microbiota in a mouse model.
Li W, Wang X, Chen K, Zhu Y, Yang G, Jin Y, Wang J
Veterinary research 2025 Feb 8;56(1):35
Veterinary research 2025 Feb 8;56(1):35
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis.
Huo JL, Fu W, Feng Q, Pan S, Liu D, Liu Z
Clinical science (London, England : 1979) 2025 Feb 6;139(3):229-46
Clinical science (London, England : 1979) 2025 Feb 6;139(3):229-46
Novel therapeutic strategy: Nrf2 activation in targeting senescence-related changes in chronic obstructive pulmonary disease.
Jin F, Lin H, Pan S
Journal of thoracic disease 2025 Feb 28;17(2):623-640
Journal of thoracic disease 2025 Feb 28;17(2):623-640
Bifidobacterium bifidum reduces oxidative stress and alters gut flora to mitigate acute liver injury caused by N-acetyl-p-aminophenol.
Yin J, Chen L, Lin Y, Qiu J, Liu F, Wang Y, Dou X
BMC microbiology 2025 Feb 25;25(1):87
BMC microbiology 2025 Feb 25;25(1):87
Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways.
Li Z, Ran Q, Qu C, Hu S, Cui S, Zhou Y, Shen B, Yang B
Biology direct 2025 Feb 25;20(1):23
Biology direct 2025 Feb 25;20(1):23
Aminophylline targets miR-128-3p/Slc7a11 axis to attenuate neuronal ferroptosis after traumatic brain injury.
Manrui L, Xu Y, Liu J, Zhang X, Yuan R, Sun Y, Sun Y, Yang Q, Liao M, Lv M, Hu X, Chen X, Liang W
Cellular and molecular life sciences : CMLS 2025 Feb 22;82(1):87
Cellular and molecular life sciences : CMLS 2025 Feb 22;82(1):87
Targeted temperature management alleviates post-resuscitation myocardial dysfunction by inhibiting ferroptosis.
Zhang Y, Du W, Kong T, Hua T, Ma H, Hu Y, Pan S, Ling B, Yang M, Cheng C
Cell death discovery 2025 Feb 21;11(1):71
Cell death discovery 2025 Feb 21;11(1):71
Scopoletin alleviates acetaminophen-induced hepatotoxicity through modulation of NLRP3 inflammasome activation and Nrf2/HMGB1/TLR4/NF-κB signaling pathway.
Yuan Y, Zhang J, Li H, Yuan F, Cui Q, Wu D, Yuan H, Piao G
International immunopharmacology 2025 Feb 20;148:114132
International immunopharmacology 2025 Feb 20;148:114132
Abscisic acid improves non-alcoholic fatty liver disease in mice through the AMPK/NRF2/KEAP1 signaling axis.
Zhang L, Du FH, Kun KX, Yan Y
Biochemical and biophysical research communications 2025 Feb 2;747:151291
Biochemical and biophysical research communications 2025 Feb 2;747:151291
Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions.
Wu Y, Zhang Z, Ren M, Chen Y, Zhang J, Li J, Gao F, Bao Y, Huang Y, Yang X, Song Z
Cells 2025 Feb 2;14(3)
Cells 2025 Feb 2;14(3)
p16(INK4a) promoted progress of MCT induced pulmonary hypertension via maintaining redox balance and autophagy pathway.
Wang F, Xiao W, Li J, Zhang Z, Zhang X, Sun J, Zhong Y, Wang X, Zhuang R, Gu X
Biochemical and biophysical research communications 2025 Feb 16;749:151385
Biochemical and biophysical research communications 2025 Feb 16;749:151385
Esketamine alleviates LPS-induced depression-like behavior by activating Nrf2-mediated anti-inflammatory response in adolescent mice.
Ma X, Xue S, Ma H, Saeed S, Zhang Y, Meng Y, Chen H, Yu H, Wang H, Hu S, Cai M
Neuroscience 2025 Feb 16;567:294-307
Neuroscience 2025 Feb 16;567:294-307
Brown Algae Polysaccharides Alleviate Diquat-Induced Oxidative Stress in Piglets and IPEC-J2 Cells via Nrf2/ARE Signaling Pathway.
Hou C, Yu Z, Shi C, Huang Y, Liu H
Animals : an open access journal from MDPI 2025 Feb 14;15(4)
Animals : an open access journal from MDPI 2025 Feb 14;15(4)
l-Glutamic Acid Alleviates Mastitis in Dairy Cows by Targeting the Sirt5/Nrf2/Prdx1 Signaling Axis and Mitochondrial Function.
Liu S, Jin Y, Zhou W, Liu J, Tu L, Zhang Y, Zhang M, Liu X, Cao Y, Guo W, Fu S
Journal of agricultural and food chemistry 2025 Feb 12;73(6):3483-3493
Journal of agricultural and food chemistry 2025 Feb 12;73(6):3483-3493
PANAXADIOL SAPONIN ALLEVIATES LPS-INDUCED CARDIOMYOPATHY SIMILAR TO DEXAMETHASONE VIA IMPROVING MITOCHONDRIAL QUALITY CONTROL.
Yang Z, Gao Y, Li D, Zhao L, Du Y
Shock (Augusta, Ga.) 2025 Feb 1;63(2):282-291
Shock (Augusta, Ga.) 2025 Feb 1;63(2):282-291
Puerarin reduces susceptibility to ventricular arrhythmias and inhibits ferroptosis via Sirt1/Nrf2 signaling in high-fat-diet rats.
Jiang S, Qiu S, Mu Y, Liu C, Han Y, Jiang J, Wang Y
Free radical biology & medicine 2025 Feb 1;227:472-484
Free radical biology & medicine 2025 Feb 1;227:472-484
Electroacupuncture ameliorated locomotor symptoms in MPTP-induced mice model of Parkinson's disease by regulating autophagy via Nrf2 signaling.
Zhang J, Fu Z, Wen F, Lyu P, Huang S, Cai X, Zhang Z, Zhang Y, Fan C, Man W, Sun X, Huang Y
Journal of neurophysiology 2025 Feb 1;133(2):490-501
Journal of neurophysiology 2025 Feb 1;133(2):490-501
Nuclear factor E2 related factor 2 may alleviate liver injury by regulating iron overload and lipid peroxidation induced by chronic fluorosis.
Xiao X, Tu X, Wei N, He WW, Zeng XX, Liao W, Deng J, Dong YT, Qi XL, Xiao Y, Hong W, He Y, Lou DD, Guan ZZ
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2025 Dec;92:127775
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2025 Dec;92:127775
TRPA1 activation prompts lysosome-mediated Nrf2 degradation enhancing the killing of colorectal cancer cells.
Eskandari N, Delisi D, Vakili Saatloo M, Keceli G, Pinheiro N, Eblen S, Paolocci N, Gentile S
Redox biology 2025 Dec;88:103942
Redox biology 2025 Dec;88:103942
Indirubin regulates M1/M2 polarization and inhibits ferroptosis in dextran sulfate sodium induced colitis and in cultured THP-1 cells.
Huang YX, Zhang JR, Fu SH, Liu Z, Zhong HJ, Zhong QY, Luo YD, Hu YJ, Zhu HP, Wen B, Chen S
Pharmaceutical biology 2025 Dec;63(1):698-715
Pharmaceutical biology 2025 Dec;63(1):698-715
Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection.
Chao R, Wang Y, Liu Z, Wan T, Mao Y, Xie X, Sun L, Xu W, Chen X, Zhang S
International journal of molecular medicine 2025 Dec;56(6)
International journal of molecular medicine 2025 Dec;56(6)
SIRT6 Overexpression Enhances Diabetic Foot Ulcer Healing via Nrf2 Pathway Activation.
Wei L, Kang M, Zhang G, Meng Y, Qin H
Inflammation 2025 Dec;48(6):3858-3877
Inflammation 2025 Dec;48(6):3858-3877
Maresin-1 alleviates sepsis-induced acute kidney injury by inhibiting ferroptosis via the Nrf2/HO-1/Gpx4 signaling pathway.
Tang L, He D, Wan P, Gou X, Wang Y, Li X
Renal failure 2025 Dec;47(1):2575112
Renal failure 2025 Dec;47(1):2575112
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Chen T, Wang J, Xu Y, Zhu Y, Jin Y, Fan Q
Renal failure 2025 Dec;47(1):2521455
Renal failure 2025 Dec;47(1):2521455
Synthesis of novel pyrazole derivatives and neuroprotective effect investigation.
Feng A, Zeng Q, Wang J, Li H, Fang X, Geng Y, Pan W, Li G, Dong J
Journal of enzyme inhibition and medicinal chemistry 2025 Dec;40(1):2583820
Journal of enzyme inhibition and medicinal chemistry 2025 Dec;40(1):2583820
Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress via Sesn2/Nrf2 activation in mastitis.
Amona FM, Pang Y, Chen X, Liu Z, Su C, Yang J, Liu K, Wu Q, Liu B, Chen X, Zhang C
Materials today. Bio 2025 Dec;35:102491
Materials today. Bio 2025 Dec;35:102491
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
Gan X, Li J, Li S, Wang X, Wang Q, Chen X, Huang Y, Nie M, Kang H, Dai H
Materials today. Bio 2025 Dec;35:102359
Materials today. Bio 2025 Dec;35:102359
Bilirubin-polymer nanocarriers enable targeted farrerol delivery for glaucoma neuroprotection via Nrf2-mediated ferroptosis/apoptosis inhibition.
Wang J, Liu Y, Rong R, Xia X
Materials today. Bio 2025 Dec;35:102304
Materials today. Bio 2025 Dec;35:102304
SIRT1 inhibits ferroptosis of granulosa cells in polycystic ovarian syndrome.
An J, Qiu Y, Guo X, Zhou Q, Li P, Zhou H, Xu C
International journal of biological macromolecules 2025 Dec;334(Pt 1):148931
International journal of biological macromolecules 2025 Dec;334(Pt 1):148931
Apelin-13 Attenuates Blood-Brain Barrier Dysfunction Following Intracerebral Hemorrhage via Targeting the Keap1/Nrf2 Signaling.
Guo P, Siddique R, Qian J, Qi L, Yong VW, Xue M
CNS neuroscience & therapeutics 2025 Dec;31(12):e70706
CNS neuroscience & therapeutics 2025 Dec;31(12):e70706
ACTG1 mediates cisplatin resistance in NSCLC through induction of mitochondrial fragmentation.
Xie M, Yang Z, Zhou J, Chen X, Pu L, Xiong G, Chen M, Zhang H, Zhao Y, Yang Y
Apoptosis : an international journal on programmed cell death 2025 Dec;30(11-12):3069-3086
Apoptosis : an international journal on programmed cell death 2025 Dec;30(11-12):3069-3086
FASN regulates CSE-induced apoptosis, oxidative stress and mitochondrial damage in type 2 alveolar epithelial cells by regulating NRF2 expression and nuclear translocation.
Yang K, Zhu G, Peng T, Cheng Y, Guo X
Redox report : communications in free radical research 2025 Dec;30(1):2550412
Redox report : communications in free radical research 2025 Dec;30(1):2550412
ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1/Nrf2 signaling.
Liu X, Chen C, Zhu S, Luo X, Gao L, Hu Z, Ma Y, Jiang L, Wu Y
Redox report : communications in free radical research 2025 Dec;30(1):2529618
Redox report : communications in free radical research 2025 Dec;30(1):2529618
Oxidative stress activates the transplanted adipose-derived stem cells to exert antioxidant effects in alopecia treatment.
Sun X, Chen M
Redox report : communications in free radical research 2025 Dec;30(1):2503128
Redox report : communications in free radical research 2025 Dec;30(1):2503128
Flavonoids from Polypodium hastatum as neuroprotective agents attenuate cerebral ischemia/reperfusion injury in vitro and in vivo via activating Nrf2.
Yao H, Wu R, Du D, Ai F, Yang F, Li Y, Qi S
Redox report : communications in free radical research 2025 Dec;30(1):2440204
Redox report : communications in free radical research 2025 Dec;30(1):2440204
Overexpression of cholesterol 24-hydroxylase CYP46A1 attenuates retinal dysfunction and ganglion cell loss via regulating the Nrf2 pathway in optic nerve crush injury.
Long Z, Zhang J, Feng J, He T
Experimental eye research 2025 Dec;261:110649
Experimental eye research 2025 Dec;261:110649
Phytic acid protects corneal endothelium from UVA induced ferroptosis.
Zhou M, Zhang W, Zhang C, Fu Y, Sun H
Experimental eye research 2025 Dec;261:110647
Experimental eye research 2025 Dec;261:110647
Activation of the Nrf2/HO-1/GPX4 pathway by cGAMP Mitigates oxidative stress and ferroptosis in ischaemic stroke.
Li X, Qian S, Hou Z, Yang G, Ma Y, Gao Y, Zhang Y, Li T
Biochemical pharmacology 2025 Dec;242(Pt 2):117334
Biochemical pharmacology 2025 Dec;242(Pt 2):117334
ABI3BP deficiency alleviates Ang II-induced VSMC senescence through the Nrf2 signalling pathway.
Mao A, Tu Q, Xie H, Wang X, Liu Y, Ding Y, Cao Z
Mechanisms of ageing and development 2025 Dec;228:112104
Mechanisms of ageing and development 2025 Dec;228:112104
Renal tubular VMP1 protects against acute kidney injury via modulating autophagy and autophagy-independent pathway.
Yang W, Jia M, Zhou F, Zhang M, Qu S, Zeng C, Zhu X, Gu S, Xuan J, Liu Z, Zen K
Autophagy 2025 Dec;21(12):2792-2808
Autophagy 2025 Dec;21(12):2792-2808
Unveiling the role of Jagged2 in hypoxic pulmonary arterial hypertension: A NOX2-mediated pathway.
Yuan J, Chen Y, Wu S, Shi H, Dong Y, Han Y, Cui W
Journal of cell communication and signaling 2025 Dec;19(4):e70032
Journal of cell communication and signaling 2025 Dec;19(4):e70032
MiR-646 inhibited cell proliferation and migration by targeting P62 in glioma.
Ye F, Zhang H, Chen Q, Gui Y, Tian G, Ye Y, Chen X, Dong H, Fan X, Chen J, Yuan R, Zhao L, Yu J
Cell adhesion & migration 2025 Dec;19(1):2515763
Cell adhesion & migration 2025 Dec;19(1):2515763
Analysis of the Protective Mechanism of PGC-1α/NRF1/2/TFAM Pathway in Cortical Neuron Injury Induced by Oxidative Stress.
Li J, Zhang W, Hu W, Gao W, Wang J, Li J, Wang Y, Wang W, Gao H, Yi B
Bulletin of experimental biology and medicine 2025 Dec;180(2):259-266
Bulletin of experimental biology and medicine 2025 Dec;180(2):259-266
Bioactive peptides PDBSN improve mitochondrial function and suppression the oxidative stress in human adiposity cells.
Shen H, Lei Y, Xie W, Ma T, Bao L, Gao Q, Chen B, Dai B, Qin D
Adipocyte 2025 Dec;14(1):2278213
Adipocyte 2025 Dec;14(1):2278213
Adipose-derived mesenchymal stem cell exosomes protect keratinocytes from high-glucose injury by modulating KEAP1/NRF2/HO-1 axis.
Yuan Y, Song S, Xiao Y, Feng R, Li M, Zhang H, Luo L, Wang K, Wang P, Wei L, Zhang Y, Zhang B, Jiang S, Shen K, Guan H, Hu D
Cellular signalling 2025 Dec;136:112172
Cellular signalling 2025 Dec;136:112172
Melatonin attenuates lipopolysaccharide-induced acute myocardial injury by regulating KLF4 expression.
Dan Z, Liu W, Zhang H, Shi X, Zhu R, Yang M, Wang Y, Zhu H
Cellular signalling 2025 Dec;136:112080
Cellular signalling 2025 Dec;136:112080
Unlocking the potential of garlic by-product protein: Ultrasound-induced structural modification and fabrication of an ACE inhibitory peptide targeting endothelial dysfunction.
Xiang L, Qiu Z, Zheng Z, Chen H, Qiao Y
Ultrasonics sonochemistry 2025 Dec;123:107642
Ultrasonics sonochemistry 2025 Dec;123:107642
Pituitary adenylate cyclase-activating polypeptide (PACAP) attenuates diabetic cardiomyopathy via Nrf2/HO-1 antioxidant signaling and NF-κB-mediated inflammation suppression in streptozotocin-treated mice.
Yang D, Ruan H, Chen L, Zhang H, Liu G
Neuropeptides 2025 Dec;114:102568
Neuropeptides 2025 Dec;114:102568
Mesenchymal stem cells' exosomes alleviate chronic visceral pain through Nrf-2-mediated oxidative stress pathway in rats.
Liu Y, Li M, Lian X, Chen X, Lin C, Jin L, You J, Lai Y, Liu L, Zhu Y, Lin J
Pain reports 2025 Dec;10(6):e1372
Pain reports 2025 Dec;10(6):e1372
LncPEDS1-AS promotes UTUC resistance to lipid peroxidation by regulating PEDS1 expression via DDX23.
Li G, Zhang E, Wang Z, Zhang Z, Zhang Y, Di S, Lu J, Cao S, Xie G, Zhang Y, Li K
Cell death & disease 2025 Dec 8;17(1):87
Cell death & disease 2025 Dec 8;17(1):87
Synthesis and evaluation of lansiumamide B analogues to ameliorate acute lung injury by reducing oxidative stress and inflammation via Keap1/Nrf2/NF-κB pathway.
Song L, Li M, Li J, Liu L, Luo X, Wang J, Wu X, Huang B, Zhang G, Yao H
European journal of medicinal chemistry 2025 Dec 5;299:118052
European journal of medicinal chemistry 2025 Dec 5;299:118052
α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice.
Zheng L, Wang Y, Xiao Z, Rao Z, Shi R
International journal of molecular sciences 2025 Dec 30;27(1)
International journal of molecular sciences 2025 Dec 30;27(1)
Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study.
Xiufang L, Zhongqing W, Huidan W, Ye Z, Xu H, Wei C, Haicui W, Fang L
Journal of ovarian research 2025 Dec 30;19(1):37
Journal of ovarian research 2025 Dec 30;19(1):37
TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation.
Wu H, Zhu G, Zhu Q, Ma J, Mao S, Ding M, Zhu J, Tang X, Bian Z, Shan Y, Gu S, Sun F, Jiang C, Pan Q
Journal of experimental & clinical cancer research : CR 2025 Dec 29;44(1):329
Journal of experimental & clinical cancer research : CR 2025 Dec 29;44(1):329
Butin inhibits osteoarthritis progression by modulating the Nrf2/HO-1 signaling pathway and inhibiting NF-κB signaling.
Zhou P, Chang J, Wei X, Zhu C, Yang J, Wang C, Hu Y, Zhang C
Scientific reports 2025 Dec 26;15(1):45688
Scientific reports 2025 Dec 26;15(1):45688
Blueberry anthocyanins and their metabolites synergistically alleviated ferroptosis induced by acrylamide in HepG2 cells.
Lang Y, Gao N, Tan H, Si X, Tian J, Zang Z, Zhao D, Li B
Food chemistry 2025 Dec 25;496(Pt 2):146690
Food chemistry 2025 Dec 25;496(Pt 2):146690
ALDH3A2 negatively orchestrates gastric cancer progression through a synergistic induction of ferroptosis and ferroptosis-driven macrophage reprogramming.
Ren Y, Cui Y, Wang Z, Luo Y, Jin J, Yuan Y, Li X, Zhang Y, Cao N, Li X, Yu Y, Xiong Y
Cell death & disease 2025 Dec 24;17(1):97
Cell death & disease 2025 Dec 24;17(1):97
TRIM16 mediates YAP1 K63-linked ubiquitination to alleviate sepsis-induced acute liver injury through YAP/Nrf2 axis in mice.
Zhang K, Liu M, Zheng Y, Gao Z, Dong Z, You M, Guo Y, Liang F, Zhao Z
Cell & bioscience 2025 Dec 23;16(1):7
Cell & bioscience 2025 Dec 23;16(1):7
Ferroptosis is a novel pathogenic mechanism of FDXR-related disease via disruption of the NRF2 pathway.
Campbell T, Slone J, Vu J, Liu W, Yang L, Dourson A, Queme LF, Jankowski MP, Huang T
Cell death discovery 2025 Dec 23;11(1):563
Cell death discovery 2025 Dec 23;11(1):563
L-ascorbate prevents non-alcoholic steatohepatitis-based hepatocarcinogenesis in Sod1/Prdx4 double-knockout mice.
Osaki T, Homma T, Maeda Y, Yamada KI, Yokoyama C, Toyokuni S, Fujii J
Scientific reports 2025 Dec 22;15(1):44312
Scientific reports 2025 Dec 22;15(1):44312
Nicotinamide riboside alleviates sepsis-induced acute kidney injury by suppressing ferroptosis.
Fan S, Ma X, Ren T, Guo M, Wang X, Si M
Journal of molecular medicine (Berlin, Germany) 2025 Dec 20;104(1):10
Journal of molecular medicine (Berlin, Germany) 2025 Dec 20;104(1):10
Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis.
Ding S, Hu D, Pan Y, Wang J, Wang L
Scientific reports 2025 Dec 19;15(1):44186
Scientific reports 2025 Dec 19;15(1):44186
GSK3β-mediated NRF2 degradation drives Escherichia coli-induced ferroptosis in the bovine endometrium.
Yuan C, Dong P, Wang J, Mao P, Wang Z, Dong J, Guo L, Liu K, Cui L, Li J, Wang H
Veterinary research 2025 Dec 18;56(1):232
Veterinary research 2025 Dec 18;56(1):232
Expression and Biological Activity of Recombinant Type IV Collagen.
Chang Y, Zhang Z, Yuwen W, Xu R, Fu R, Zhu C, Li W, Duan Z, Fan D
Journal of agricultural and food chemistry 2025 Dec 17;73(50):31865-31877
Journal of agricultural and food chemistry 2025 Dec 17;73(50):31865-31877
The Neuroprotective Effect of 4-Octyl Itaconate on Acute Period of Experimental Autoimmune Neuritis.
Zhang LJ, Zhao N, Li J, Zhai H, Wu J, Yang L
Inflammation 2025 Dec 17;49(1):5
Inflammation 2025 Dec 17;49(1):5
Sappanone A Promotes Motor Function Recovery in Spinal Cord Injury Mice by Inhibiting Microglial M1 Polarization via Activation of the Keap1/Nrf2 Pathway.
Ren L, Chen Y, Xia J, Song X, Tao L, Li J, Xu L, Lü H, Hu J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 15;39(23):e71298
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 15;39(23):e71298
Sitagliptin inhibits neuronal ferroptosis to alleviate cognitive dysfunction by activating Nrf2-SLC7A11-GPX4 axis in diabetic mice.
Meng H, Xie Z, Xu T, Kong S, Wang M, Zhu Q, Zhang Y, Zhu Z, Wu M, Wang Y, Chen C, Han J, Che H
International immunopharmacology 2025 Dec 10;167:115672
International immunopharmacology 2025 Dec 10;167:115672
Nrf2/Bach1 axis regulates redox homeostasis and energy metabolism to optimize Sertoli cell-mediated efferocytosis.
Wu D, Zhang K, Tan J, Khan FA, Huang C, Sun F
Molecular and cellular endocrinology 2025 Dec 1;610:112661
Molecular and cellular endocrinology 2025 Dec 1;610:112661
Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway.
Wang Y, Zhao Y, Zhao W, Chen H, Cao Z, Li H, Tang Y, Zhu X, Yao P
Free radical biology & medicine 2025 Dec 1;240:238-252
Free radical biology & medicine 2025 Dec 1;240:238-252
Cuspidatyl Ferulate, a Novel Phenolic Acid from Hyssopus cuspidatus Borris, Protects Hepatocytes Against Oxidative Damage via Keap1 Interaction.
Liu X, Zhang Z, Gao D, Yang X, Liu L, Wang G, Song Z, Fang W, Wang S
Antioxidants (Basel, Switzerland) 2025 Dec 1;14(12)
Antioxidants (Basel, Switzerland) 2025 Dec 1;14(12)
MiR-155 overexpression regulates Th1/Th2 balance by inhibiting BACH1 to activate Nrf-2/HO-1 signaling pathway in allergic rhinitis.
Zhang Z, Ren Y, Wan W, Huang X, Liu M, Zhang H, Huang X, Yang C
Archives of biochemistry and biophysics 2025 Aug;770:110454
Archives of biochemistry and biophysics 2025 Aug;770:110454
Competitive Binding of Pseudomonas aeruginosa to Kelch-Like ECH-Associated Protein 1 Inhibits Nuclear Factor Erythroid 2-Related Factor 2 Ubiquitination and Suppresses Ferroptosis in Macrophages.
Zhu Y, Liu Q, Lu E, Li Z
Microbiology and immunology 2025 Aug;69(8):418-428
Microbiology and immunology 2025 Aug;69(8):418-428
Arbutin Preserves Boar Sperm During Storage at 17°C by Enhancing the Antioxidant Capacity via the NRF2/GPX4 Signalling.
Liu W, Li W, Lin R, Wang Y, Zhou P, Pang W, Li R, Zheng Y
Reproduction in domestic animals = Zuchthygiene 2025 Aug;60(8):e70103
Reproduction in domestic animals = Zuchthygiene 2025 Aug;60(8):e70103
HDAC3 Regulates Ferroptosis via Nrf2-GPX4 Signaling in Colorectal Cancer Cells.
Jin W, Wang JJ, Feng YF, Chen B, Hu ZH
Doklady. Biochemistry and biophysics 2025 Aug;523(1):424-433
Doklady. Biochemistry and biophysics 2025 Aug;523(1):424-433
Cadmium treatment induces oxidative damage and apoptosis in vitro skeletal muscle cells.
Wenhong L, Yang J, Zhao Y, Zhang N, Zhao B, Rongxian L, Shiyan G, Zuoshun H
Toxicology 2025 Aug;515:154139
Toxicology 2025 Aug;515:154139
Titanium Particles Activate Osteocytic Connexin 43 to Induce Oxidative Stress and Osteoclastogenesis Through the JAK-STAT Pathway.
Ouyang J, Chai H, Sun C, Wang S, She C, Geng D, Xu W
Antioxidants & redox signaling 2025 Aug;43(4-6):215-238
Antioxidants & redox signaling 2025 Aug;43(4-6):215-238
A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis.
Yang Q, Liu J, Liu Y, Liu S, Wei X, Yang Y, Zhang W, Zhang S, Zhang M, Liu B, Wang X, Zhu D
Materials today. Bio 2025 Aug;33:102009
Materials today. Bio 2025 Aug;33:102009
Dietary supplementation of Lactobacillus casei alleviates permethrin exposure-induced zebrafish testis damage through modulation of TLR4/NF-κB and AKT/Nrf2 pathways: Oxidative stress, inflammation and ferroptosis.
Huo Y, Wang Y, Ma N, Guo Y, Khan A, Mai W
Pesticide biochemistry and physiology 2025 Aug;212:106450
Pesticide biochemistry and physiology 2025 Aug;212:106450
Antroquinonol mitigates Tau hyperphosphorylation, neuronal damage and cognitive impairments in a chronic cerebral ischemia rat model.
Yang LY, Hsu CH, Cheng YW, Chen KW, Chou SC, Chen YR, Chen YT, Deng CR, Chen IC, Kuo MF, Wang KC
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118271
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118271
Discovery of a novel polyketide-derived ferroptosis inhibitor from endophytic fungus Ophiobolus cirsii LZU-1509 with therapeutic potential in ischemic stroke.
Xi J, Ren H, Zhang W, Wang Z, Zhao H, Wu QX, Fang J
Bioorganic chemistry 2025 Aug;163:108656
Bioorganic chemistry 2025 Aug;163:108656
Unveiling the renoprotective mechanisms of self-assembled herbal nanoparticles from Scutellaria barbata and Scleromitrion diffusum in acute kidney injury: A nano-TCM approach.
Xia L, Yang Q, Fu K, Yang Y, Ding K, Huo Y, Zhang L, Li Y, Zhu B, Li P, Huo Y, Sun L, Liu Y, Zhang H, Liu T, Shan W, Zhang L
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4265-4284
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4265-4284
Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8-AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma.
Chen ZW, Shan JJ, Chen M, Wu Z, Zhao YM, Zhu HX, Jin X, Wang YX, Wu YB, Xiang Z, Ding ZW, Lin ZH, Wang LR, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e01042
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e01042
Atractylenolide III alleviates amyloid-β-induced cognitive impairments in mice.
Yuan H, Xia L, Li J, Dai C, Li X, Xu B, Xue M, Shi X, Wu B, Dong Z, Pang Y
Molecular biology reports 2025 Aug 7;52(1):799
Molecular biology reports 2025 Aug 7;52(1):799
The foam cell-derived exosomes exacerbate ischemic white matter injury via transmitting metabolic defects to microglia.
Zhang H, Zhou LQ, Yang S, Dong MH, Chen L, Lu YL, Zhang LY, Zhang L, Chu YH, Xu LL, Pang XW, Zhu LF, Xu T, Yong TY, Wang W, Tian DS, Qin C
Cell metabolism 2025 Aug 5;37(8):1636-1654.e10
Cell metabolism 2025 Aug 5;37(8):1636-1654.e10
Periplocin potentiates ferroptotic cell death in non-small cell lung cancer by inducing the degradation of Nrf2.
Wang J, Zhu Y, Song J, Yang F, Wang P, Zhang Z, Li Y, Dai M, Wang Y, Yousuf W, Li J, Yang D, Cheng S, Liu S, Dai Z, Qiu X, Zhang Y, Hu Z
Cancer cell international 2025 Aug 4;25(1):294
Cancer cell international 2025 Aug 4;25(1):294
Novel therapeutic approach in periodontitis: Sulforaphane attenuates disease progression via Nrf2-mediated antioxidant defense.
Liu Y, Li T, Liao Y, Chen J, Sheng Y, Zhao Y, He Z, Tang H, Wang Y, Bian Z, Ji Y
International immunopharmacology 2025 Aug 28;161:115002
International immunopharmacology 2025 Aug 28;161:115002
Targeting Irgm1 to combat osteoporosis: suppressing ROS and restoring bone remodeling.
Cui Z, Gu G, Chen F, Li J, Du X, Chen S, Zhang H, Li C, Shao J, Xi J, Du Y, Zhao Q, Xi Y
Cell death & disease 2025 Aug 27;16(1):651
Cell death & disease 2025 Aug 27;16(1):651
Degraded Polysaccharides from Noni (Morinda citrifolia L.) juice Mitigate Glucose Metabolism Disorders by Regulating PI3K/AKT-Nrf2-GSK3β Signaling Pathways in HepG2 Cells.
Wei X, Du P, Luo Y, Zhao Y, Zhou X, Chen G, Zhang B
Foods (Basel, Switzerland) 2025 Aug 27;14(17)
Foods (Basel, Switzerland) 2025 Aug 27;14(17)
Lysionotin attenuates bleomycin-induced pulmonary fibrosis by activating AMPK/Nrf2 pathway.
Zhang X, Xiong D, Deng L, Qian R, Tang S, Liu W, Li Y, Liu L, Xie W, Lin M
Scientific reports 2025 Aug 25;15(1):31306
Scientific reports 2025 Aug 25;15(1):31306
Isolation and identification of a new porcine astrovirus 5 demonstrated that oxidative stress enhances porcine astrovirus replication.
Du Y, Qin Y, Feng X, Luo Y, Lv Y, Song S, Wei X, Ouyang K, Yin Y, Chen Y, Wei Z, Huang W, Qin Y
BMC veterinary research 2025 Aug 19;21(1):518
BMC veterinary research 2025 Aug 19;21(1):518
Validated target-based network pharmacology reveals that salvianolic acid C attenuates doxorubicin-induced cardiotoxicity by regulating apoptosis and oxidative stress.
Chen S, Jiang C, Yi X, Shu Q, Feng Y, Zhong L, Huang M, Zhu J, Fang L
Biochemical and biophysical research communications 2025 Aug 15;775:152196
Biochemical and biophysical research communications 2025 Aug 15;775:152196
Luteolin attenuates trimethyltin chloride-induced hippocampal neurotoxicity through SIRT3/NRF2/HO-1 activation.
Ding N, Wang P, Fang Y, Hu Y, Wang W, Wei J, Yu J, Cai F
Neuropharmacology 2025 Aug 15;274:110461
Neuropharmacology 2025 Aug 15;274:110461
Development of Hydrogen Sulfide-Donating Silybin Derivatives with a Type-2 Diabetes Mellitus-Alleviating Effect through Improving Intestinal L-Cell Functions.
Li H, Ma Q, Li X, Zheng C, Lin L, Gu J, Huang X, Yang H, Xu H, Xu F, Hua H, Cheng M, Li D
Journal of medicinal chemistry 2025 Aug 14;68(15):15520-15542
Journal of medicinal chemistry 2025 Aug 14;68(15):15520-15542
Unveiling Xuanshen decoction: A novel approach to combat slow transit constipation.
Zeng XL, Zhu LJ, Zhang Y, Yang XD, Zhu YJ
World journal of gastroenterology 2025 Aug 14;31(30):109187
World journal of gastroenterology 2025 Aug 14;31(30):109187
The ALDH2/PolG2 axis enhances mitochondrial biogenesis via transcriptional regulation of Nrf2 and promotes chemotherapy resistance in acute myeloid leukaemia.
Hu X, Hu T, Cao S, Jiang L, Zhou Y, Fang Q, Wang J
Cell death & disease 2025 Aug 13;16(1):616
Cell death & disease 2025 Aug 13;16(1):616
Panobinostat potentiates adagrasib-induced cell death by triggering autophagy in human non-small cell lung cancer.
Lu H, Fu W, Xia Y, Yan Y, Shu C, Chen Y, Xu C, Zheng P, Shen X, Cui R, Zou P, Ni D
Cell death discovery 2025 Aug 1;11(1):360
Cell death discovery 2025 Aug 1;11(1):360
Dental pulp stem cells derived exosomes inhibit ferroptosis via regulating the Nrf2-keap1/GPX4 signaling pathway to ameliorate chronic kidney disease injury.
Luo L, Wang J, Zhao J, Yang B, Ma W, Lin J
Tissue & cell 2025 Apr;93:102670
Tissue & cell 2025 Apr;93:102670
NRF2 deficiency leads to inadequate beta cell adaptation during pregnancy and gestational diabetes.
Haidery F, Lambertini L, Tse I, Dodda S, Garcia-Ocaña A, Scott DK, Baumel-Alterzon S
Redox biology 2025 Apr;81:103566
Redox biology 2025 Apr;81:103566
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Fang M, Lu L, Lou J, Ou J, Yu Q, Tao X, Zhu J, Lin Z
Molecular neurobiology 2025 Apr;62(4):4743-4768
Molecular neurobiology 2025 Apr;62(4):4743-4768
Evidence that a Novel Chalcone Derivative, Compound 27, Acts on the Epithelium Via the PI3K/AKT/Nrf2-Keap1 Signaling Pathway, to Mitigate LPS-Induced Acute Lung Injury in Mice.
Zhou L, Lin Y, Zhou T, Xue Y, Bellusci S, Shen M, Chen C, Chen C
Inflammation 2025 Apr;48(2):590-606
Inflammation 2025 Apr;48(2):590-606
Liposomes-Loaded miR-9-5p Alleviated Hypoxia-Ischemia-Induced Mitochondrial Oxidative Stress by Targeting ZBTB20 to Inhibiting Nrf2/Keap1 Interaction in Neonatal Mice.
Zhao Y, Gai C, Yu S, Song Y, Gu B, Luo Q, Wang X, Hu Q, Liu W, Liu D, Wang Z
Antioxidants & redox signaling 2025 Apr;42(10-12):512-528
Antioxidants & redox signaling 2025 Apr;42(10-12):512-528
Thermo-sensitive ε-polylysine-heparin-poloxamer hydrogel-encapsulated BMSCs promote endometrial regeneration.
Han R, Zhou H, Liang X, He S, Sun X, Guan Y, Song Y
Materials today. Bio 2025 Apr;31:101580
Materials today. Bio 2025 Apr;31:101580
Acute hyperglycemia impedes spinal cord injury recovery via triggering excessive ferroptosis of endothelial cells.
Wu M, Zhang S, Wu X, Zhou Y, Zhou M, Du A, Zhang Y, Wei T, Wang B, Wang S, Jiang C, Hu S, Xiao J, Wu Y
International journal of biological macromolecules 2025 Apr;301:140453
International journal of biological macromolecules 2025 Apr;301:140453
Chlorogenic acid mitigates heat stress-induced oxidative damage in bovine mammary epithelial cells by inhibiting NF-κB-mediated NLRP3 inflammasome activation via upregulating the Nrf2 signaling pathway.
Huang Q, Shan Q, Ma F, Li S, Sun P
International journal of biological macromolecules 2025 Apr;301:140133
International journal of biological macromolecules 2025 Apr;301:140133
Sagittaria sagittifolia polysaccharide extract regulates Nrf2 to improve endoplasmic reticulum stress-mediated apoptosis in rat cataracts and HLEB3 cells.
Zhou MY, Liu BQ, Gao X, Zhang SJ, Jiang Y, Yang T, Sun JB, Zhang X, Liao Y
International journal of biological macromolecules 2025 Apr;300:140270
International journal of biological macromolecules 2025 Apr;300:140270
MitoQ alleviates H(2)O(2)-induced mitochondrial dysfunction in keratinocytes through the Nrf2/PINK1 pathway.
Zhao Y, Xiong R, Jin S, Li Y, Dong T, Wang W, Song X, Guan C
Biochemical pharmacology 2025 Apr;234:116811
Biochemical pharmacology 2025 Apr;234:116811
Nrf2 alleviates acute ischemic stroke induced ferroptosis via regulating xCT/GPX4 pathway.
Ye Y, Xie X, Bi Y, Liu Q, Qiu L, Zhao H, Wang C, Zhu W, Zeng T
Free radical biology & medicine 2025 Apr;231:153-162
Free radical biology & medicine 2025 Apr;231:153-162
Total alkaloids from Thesium chinense inhibit lipopolysaccharide-induced respiratory inflammation by modulating Nrf2/NF-κB/NLRP3 signaling pathway.
Li G, Guan Y, Xu L, Peng G, Han Q, Wang T, Xu Z, Wen X, Lou H, Shen T
Chinese journal of natural medicines 2025 Apr;23(4):421-430
Chinese journal of natural medicines 2025 Apr;23(4):421-430
In vivo and In vitro assessment of the retinal toxicity of polystyrene nanoplastics.
Zheng J, He L, Shi Q, Wang M, Ma Y, Yu W, Liu L, Yu G, Liu X, Wang B, Zhong J
Environment international 2025 Apr;198:109420
Environment international 2025 Apr;198:109420
Long term exposure to multiple environmental stressors induces mitochondrial dynamics imbalance in testis: Insights from metabolomics and transcriptomics.
Jiang S, Nong T, Yu T, Qin Z, Huang J, Yin Z, Luo S, Lai Y, Jin J
Environment international 2025 Apr;198:109390
Environment international 2025 Apr;198:109390
Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections.
Cotzomi-Ortega I, Rosowski EE, Wang X, Sanchez-Zamora YI, Lopez-Torres JM, Sanchez-Orellana G, Han R, Vásquez-Martínez G, Andrade GM, Ballash G, Cortado H, Li B, Ali Y, Rascon R, Robledo-Avila F, Partida-Sanchez S, Pérez-Campos E, Olofsson-Sahl P, Zepeda-Orozco D, Spencer JD, Becknell B, Ruiz-Rosado JD
Mucosal immunology 2025 Apr;18(2):402-417
Mucosal immunology 2025 Apr;18(2):402-417
p16(INK4a) Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance.
Li B, Wang K, Wang X, Zhang Z, Huang G, Ma Y, Du Y, Gu X, Hui J
Journal of cardiovascular translational research 2025 Apr;18(2):375-391
Journal of cardiovascular translational research 2025 Apr;18(2):375-391
EGCG inhibits tobacco smoke-promoted proliferation of lung cancer cells through targeting CCL5.
Dong Z, Wu J, He L, Xie C, Geng S, Wu J, Ji X, Chen X, Zhong C, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156512
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156512
Yinaoxin granule alleviates cerebral ischemia-reperfusion injury by ferroptosis inhibition through Nrf2 pathway activation.
Weng J, Liu L, Li S, Yang Y, Zhou R, Zhang Z, Liu Y, Chen L, Feng Z, Tang Z, Xu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156476
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156476
Baicalin Ameliorates L-Glutamate-Induced Hippocampal Oxidative Stress Injury and Apoptosis in Mice by Regulating Nrf2/HO-1 Signalling Pathway.
Li F, Huang Z, Gou H, Zheng J, Yao M
Basic & clinical pharmacology & toxicology 2025 Apr;136(4):e70024
Basic & clinical pharmacology & toxicology 2025 Apr;136(4):e70024
Canagliflozin-induced renal glutathione distribution mapping in non-diabetic male rat kidneys.
Watanabe G, Horita S, Moriya RF, Masuishi Y, Misaka S, Taira S, Shimomura K, Shimabukuro M, Kazama JJ
Physiological reports 2025 Apr;13(7):e70320
Physiological reports 2025 Apr;13(7):e70320
Nrf2 Deficiency Brings About Increased Sensitive to IR and 7,12-dimethylbenz(a)anthracene and Leukemia Predisposition.
Dong M, Yang P, Zhang X, Nie S, Sun X
Dose-response : a publication of International Hormesis Society 2025 Apr-Jun;23(2):15593258251341593
Dose-response : a publication of International Hormesis Society 2025 Apr-Jun;23(2):15593258251341593
Dexmedetomidine Promotes Angiogenesis After Ischemic Stroke Through the NRF2/HO-1/VEGF Pathway.
Tao Z, Li P, Tang Y, Yang W, Li Y, Yang J, Tian J, Zhang Y, Zou Y, Xu B, Zhao X
Neurochemical research 2025 Apr 9;50(2):138
Neurochemical research 2025 Apr 9;50(2):138
MTCH2 regulates NRF2-mediated RRM1 expression to promote melanoma proliferation and dacarbazine insensitivity.
Zhang X, Li E, Kuang Y, Gai Y, Feng Y, Huang Y, Wei Z, Niu J, Yu S, Yang Z, Zhang Q, Sai B, Zhu Y
Cell death & disease 2025 Apr 9;16(1):268
Cell death & disease 2025 Apr 9;16(1):268
ELANE enhances KEAP1 protein stability and reduces NRF2-mediated ferroptosis inhibition in metabolic dysfunction-associated fatty liver disease.
Yang Q, Shen X, Luo Y, Li R, Meng X, Xu P, Liu X, Bian D, Wang J, Shi J, Chen J
Cell death & disease 2025 Apr 9;16(1):266
Cell death & disease 2025 Apr 9;16(1):266
Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis.
Li M, Wang Y, Li X, Xu J, Yan L, Tang S, Liu C, Shi M, Liu R, Zhao Y, Zhang Y, Yang L, Zhang Y, Wang G, Li Z, Guo Y, Feng Y, Liu P
Cell death & disease 2025 Apr 6;16(1):257
Cell death & disease 2025 Apr 6;16(1):257
Calycosin, a Bioactive Isoflavone, Ameliorates Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Intestinal Cell Damage Model via the Nrf2 and NF-κB Signaling Pathways.
Li L, Che Y, Zhu L, Liu Z, Song Y, Wu Q, Chen M, Wang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 30;39(8):e70550
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 30;39(8):e70550
TAZ/NRF2 positive feedback loop contributes to proliferation in bladder cancer through antagonistic ferroptosis.
Song Z, Gui S, Rao X, Zhang G, Cheng Y, Zeng T
Cell death discovery 2025 Apr 29;11(1):208
Cell death discovery 2025 Apr 29;11(1):208
Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration.
Liu Y, Wang Y, Wang X, Zeng W, Zhang Z, Zhang Z, Qi Z
Pharmaceutics 2025 Apr 26;17(5)
Pharmaceutics 2025 Apr 26;17(5)
Lactiplantibacillus plantarum -derived extracellular vesicles alleviate acute lung injury by inhibiting ferroptosis of macrophages.
Zhao Q, Lai J, Jiang Y, Cui E, Chang H, Pan R, Li P, Shao JZ, Zheng J, Chen Y
Journal of nanobiotechnology 2025 Apr 23;23(1):307
Journal of nanobiotechnology 2025 Apr 23;23(1):307
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms.
Xia Q, Zhong R, Zheng J, Zhou X, Zhao X, Wang S, Wang B, Wu Q, Xie C, Kong B, Zhang Q, Huang T
Cell reports 2025 Apr 22;44(4):115484
Cell reports 2025 Apr 22;44(4):115484
GNF-5837 attenuates acute liver injury by inhibiting oxidative stress.
Zhou X, Luo X, Huang Q, Ru Y, Liu D, Linghu M, Huang Y
Molecular biology reports 2025 Apr 21;52(1):407
Molecular biology reports 2025 Apr 21;52(1):407
Electroacupuncture Ameliorates Chronic Inflammatory Pain and Depression Comorbidity by Inhibiting Nrf2-Mediated Ferroptosis in Hippocampal Neurons.
Liu G, Liu D, Shi D, Wang Z, Fu W
Neurochemical research 2025 Apr 21;50(3):149
Neurochemical research 2025 Apr 21;50(3):149
Regulation of the Nrf2/HO-1 pathway in chronic obstructive pulmonary disease-induced muscle atrophy using Jinshui Liujian decoction and Bajitian pills: insights from network pharmacology and animal models.
Lin BY, Bai L, Wang SL
Hereditas 2025 Apr 21;162(1):66
Hereditas 2025 Apr 21;162(1):66
Isolation and Identification of a Novel Antioxidant Peptide from Fermented Sea Cucumber (Stichopus japonicus) Intestine and Its Protective Effects on HepG2 Cells from Oxidative Damage.
Lv X, Yuan S, Sun Y, Zhang Y, Yang W, Xu H, Yan W, Bai Q, Bai F, Cui F, Li J, Li X, Wang Z, Zhang G, Hou P
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9062-9075
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9062-9075
Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity.
Wang F, Amona FM, Pang Y, Zhang Q, Liang Y, Chen X, Ke Y, Chen J, Song C, Wang Y, Li Z, Zhang C, Fang X, Chen X
Journal of virology 2025 Apr 15;99(4):e0158524
Journal of virology 2025 Apr 15;99(4):e0158524
Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management.
Zhao Z, Lu H, Wang J, Wu T, Xu S, Ge Y, You Q, Jiang Z, Lu M
European journal of medicinal chemistry 2025 Apr 15;288:117384
European journal of medicinal chemistry 2025 Apr 15;288:117384
TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer.
Huang C, Zeng Q, Chen J, Wen Q, Jin W, Dai X, Ruan R, Zhong H, Xia Y, Wu Z, Huang R, Zhang J, Yao Y, Li L, Lei W, Xiong J, Deng J
Cell death & disease 2025 Apr 13;16(1):287
Cell death & disease 2025 Apr 13;16(1):287
Mechanism of dracorhodin in accelerating diabetic foot ulcer healing via the Nrf2 pathway, a network pharmacology, molecular docking and experimental validation.
Tang G, Wang Y, Deng P, Wu J, Lu Z, Zhu R, Guo H, Zhang Y, Mo X, Chen Z
Scientific reports 2025 Apr 11;15(1):12492
Scientific reports 2025 Apr 11;15(1):12492
The mitochondrial NAD transporter SLC25A51 is a modulator of beta cell senescence and type 2 diabetes.
Kong BS, L'Yi S, Ramirez-Hernandez EG, Hong S, Weidenspointner R, Song S, Caserta C, Cho YM, Kory N
bioRxiv : the preprint server for biology 2025 Apr 11;
bioRxiv : the preprint server for biology 2025 Apr 11;
SIRT7-mediated NRF2 deacetylation promotes antioxidant response and protects against chemodrug-induced liver injury.
Yu T, Ding C, Peng J, Liang G, Tang Y, Zhao J, Li Z
Cell death & disease 2025 Apr 1;16(1):232
Cell death & disease 2025 Apr 1;16(1):232
Time of day differences in the regulation of glutathione levels in the rat lens.
Li B, Suzuki-Kerr H, Martis RM, Lim CJJ, Wang ZA, Nguyen TX, Donaldson PJ, Poulsen RC, Lim JC
Frontiers in ophthalmology 2024;4:1407582
Frontiers in ophthalmology 2024;4:1407582
Therapeutic potential of HUC-MSC-exos primed with IFN-γ against LPS-induced acute lung injury.
Wang C, Jiang C, Yang Y, Xi C, Yin Y, Wu H, Qian C
Iranian journal of basic medical sciences 2024;27(3):375-382
Iranian journal of basic medical sciences 2024;27(3):375-382
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.
Xiang C, Lu Y, Hao R, Wei Y, Hu Y, Yu G
Iranian journal of basic medical sciences 2024;27(12):1547-1557
Iranian journal of basic medical sciences 2024;27(12):1547-1557
CPEB1 Controls NRF2 Proteostasis and Ferroptosis Susceptibility in Pancreatic Cancer.
Zhang S, Huang J, Lan Z, Xiao Y, Liao Y, Basnet S, Huang P, Li Y, Yan J, Sheng Y, Zhou W, Liu Q, Tan H, Tan Y, Yuan L, Wang L, Dai L, Zhang W, Du C
International journal of biological sciences 2024;20(8):3156-3172
International journal of biological sciences 2024;20(8):3156-3172
PRDX1 inhibits ferroptosis by binding to Cullin-3 as a molecular chaperone in colorectal cancer.
Song Y, Wang X, Sun Y, Yu N, Tian Y, Han J, Qu X, Yu X
International journal of biological sciences 2024;20(13):5070-5086
International journal of biological sciences 2024;20(13):5070-5086
Benfotiamine protects MPTP-induced Parkinson's disease mouse model via activating Nrf2 signaling pathway.
Wang K, Han C, Yang J, Xu W, Wang L, Li H, Wang Y
PloS one 2024;19(7):e0307012
PloS one 2024;19(7):e0307012
Therapeutic potential of salidroside in type I diabetic erectile dysfunction: Attenuation of oxidative stress and apoptosis via the Nrf2/HO-1 pathway.
Li Z, Jia B, Guo Z, Zhang K, Zhao D, Li Z, Fu Q
PloS one 2024;19(7):e0306926
PloS one 2024;19(7):e0306926
The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein.
Zhang D, Li J, Zhang C, Xue J, Li P, Shang K, Zhang X, Lang B
Open life sciences 2024;19(1):20220935
Open life sciences 2024;19(1):20220935
Dual-Stimuli-Responsive Gut Microbiota-Targeting Nitidine Chloride-CS/PT-NPs Improved Metabolic Status in NAFLD.
Lu J, Zeng Y, Zhong H, Guo W, Zhang Y, Mai W, Qin Y, Su X, Zhang B, Wu W, Zhu Y, Huang Q, Ye Y
International journal of nanomedicine 2024;19:2409-2428
International journal of nanomedicine 2024;19:2409-2428
Artesunate-Nanoliposome-TPP, a Novel Drug Delivery System That Targets the Mitochondria, Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Stress and Inflammatory Effects.
Zhang J, Gu L, Jiang Y, Ma Y, Zhang Z, Shen S, Shen S, Peng Q, Xiao W
International journal of nanomedicine 2024;19:1385-1408
International journal of nanomedicine 2024;19:1385-1408
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats.
Zhou X, Wang X, Li J, Zhang M, Yang Y, Lei S, He Y, Yang H, Zhou D, Guo C
Drug design, development and therapy 2024;18:699-717
Drug design, development and therapy 2024;18:699-717
Exploring the Effect and Mechanism of DaYuan Yin Against Acute Lung Injury by Network Pharmacology, Molecular Docking, and Experimental Validation.
Zhang L, Zhu W, Zhang C
Drug design, development and therapy 2024;18:5541-5561
Drug design, development and therapy 2024;18:5541-5561
ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1.
Liu T, Wang L, Shi T, Liu H, Liu B, Guo J, Li M
Drug design, development and therapy 2024;18:3903-3919
Drug design, development and therapy 2024;18:3903-3919
Systematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in Osteoarthritis.
Chen K, Yu Y, Wang Y, Zhu Y, Qin C, Xu J, Zou X, Tao T, Li Y, Jiang Y
Drug design, development and therapy 2024;18:259-275
Drug design, development and therapy 2024;18:259-275
The Mechanism of Catalpol to Improve Oxidative Damage of Dermal Fibroblasts Based on Nrf2/HO-1 Signaling Pathway.
Lang X, Xu L, Li L, Feng X
Drug design, development and therapy 2024;18:2287-2297
Drug design, development and therapy 2024;18:2287-2297
Long-term aerobic exercise improves learning memory capacity and effects on oxidative stress levels and Keap1/Nrf2/GPX4 pathway in the hippocampus of APP/PS1 mice.
Wang S, Zhou Y, Wu Y, Lang Y, Mao Y, Pan G, Gao Z
Frontiers in neuroscience 2024;18:1505650
Frontiers in neuroscience 2024;18:1505650
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis.
Zhou Y, Yang Y, Yi L, Pan M, Tang W, Duan H
Drug design, development and therapy 2024;18:1349-1368
Drug design, development and therapy 2024;18:1349-1368
Obacunone Alleviates Inflammatory Pain by Promoting M2 Microglial Polarization and by Activating Nrf2/HO-1 Signaling Pathway.
Nan F, Tian Q, Chen S
Drug design, development and therapy 2024;18:1265-1275
Drug design, development and therapy 2024;18:1265-1275
5-Methoxytryptophan Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating Nrf2-Mediated Mitophagy.
Sun X, Wang H, Liu Y, Yang Y, Wang Y, Liu Y, Ai S, Shan Z, Luo P
Journal of inflammation research 2024;17:9857-9873
Journal of inflammation research 2024;17:9857-9873
MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease.
Dong J, Liu M, Bian Y, Zhang W, Yuan C, Wang D, Zhou Z, Li Y, Shi Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:75-92
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:75-92
Diosgenin derivative ML5 attenuates MPTP-induced neuronal impairment via regulating AMPK/PGC-1α-mediated mitochondrial biogenesis and fusion/fission.
Fan JJ, Ding WD, Liang YF, Wei YX, Huang Y, Ma L, Wang R
American journal of translational research 2024;16(8):3582-3598
American journal of translational research 2024;16(8):3582-3598
Modified Buyang Huanwu Decoction alleviates diabetic liver injury via inhibiting oxidative stress in db/db mice.
Zhang X, Yang F, Zhang Y, Song X, Xue S, Chang Y, Zhong Y, Dou Y, Wang Y
American journal of translational research 2024;16(1):39-50
American journal of translational research 2024;16(1):39-50
miR-141-3p promotes paclitaxel resistance by attenuating ferroptosis via the Keap1-Nrf2 signaling pathway in breast cancer.
Duan WL, Wang XJ, Guo A, Gu LH, Sheng ZM, Luo H, Yang LX, Wang WH, Zhang BG
Journal of Cancer 2024;15(17):5622-5635
Journal of Cancer 2024;15(17):5622-5635
Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway.
Luan J, Yu M, Gu Q, Zhou X, Shao Y, Chen T, Zhang J, Zhu Z, Song N, Yang J
Frontiers in immunology 2024;15:1532021
Frontiers in immunology 2024;15:1532021
Polydatin protects against DSS-induced ulcerative colitis via Nrf2/Slc7a11/Gpx4-dependent inhibition of ferroptosis signalling activation.
Zheng S, Yin J, Wang B, Ye Q, Huang J, Liang X, Wu J, Yue H, Zhang T
Frontiers in pharmacology 2024;15:1513020
Frontiers in pharmacology 2024;15:1513020
Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cells.
Hou X, Mao L, Zhang H, Wang L, He B, Guo J, Wang J
Frontiers in pharmacology 2024;15:1509520
Frontiers in pharmacology 2024;15:1509520
Tetramethylpyrazine inhibits ferroptosis in spinal cord injury by regulating iron metabolism through the NRF2/ARE pathway.
Tao J, Zhou J, Zhu H, Xu L, Yang J, Mu X, Fan X
Frontiers in pharmacology 2024;15:1503064
Frontiers in pharmacology 2024;15:1503064
Huyang Yangkun formula regulates the mitochondria pathway of ovarian granulosa cell apoptosis through FTO/m6A-P53 pathway.
Li Y, Wang L, Liu J, Nie G, Yang H
Frontiers in pharmacology 2024;15:1491546
Frontiers in pharmacology 2024;15:1491546
Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis.
Huang R, Chu D, Shi J, Xu R, Wang K
Frontiers in pharmacology 2024;15:1490759
Frontiers in pharmacology 2024;15:1490759
β-cryptoxanthin suppresses oxidative stress via activation of the Nrf2/HO-1 signaling pathway in diabetic kidney disease.
Ke J, Zang H, Liu Y, Teng Q, Hua J, Peng D, Wang P
Frontiers in pharmacology 2024;15:1480629
Frontiers in pharmacology 2024;15:1480629
A novel hollow iron nanoparticle system loading PEG-Fe(3)O(4) with C5a receptor antagonist for breast cancer treatment.
Yang H, Li G, Zhang J, Zhao J, Zhao Y, Wu Y, Sun Z, Song S, Zou Y, Zou Z, Han X, Deng B, Wang L, Rao H, Xu G, Wang S, Guo S, Ding H, Shi Y, Wu Y, Chen J
Frontiers in immunology 2024;15:1466180
Frontiers in immunology 2024;15:1466180
Dexmedetomidine regulates the anti-oxidation and autophagy of adipose-derived stromal cells under H(2)O(2)-induced oxidative stress through Nrf2/p62 pathway and improves the retention rate of autologous fat transplantation.
Li Z, Wei Q, Li Y, Yang F, Ke C, Li T, Li L, Cai Z
Frontiers in pharmacology 2024;15:1453938
Frontiers in pharmacology 2024;15:1453938
Li-Hong Tang alleviates dextran sodium sulfate-induced colitis by regulating NRF2/HO-1 signaling pathway and gut microbiota.
Gu H, Tian Y, Xia J, Deng X, Chen J, Jian T, Ma J
Frontiers in pharmacology 2024;15:1413666
Frontiers in pharmacology 2024;15:1413666
Protective effect of dexmedetomidine against delayed bone healing caused by morphine via PI3K/Akt mediated Nrf2 antioxidant defense system.
Lou Y, Zou L, Shen Z, Zheng J, Lin Y, Zhang Z, Chen X, Pan J, Zhang X
Frontiers in pharmacology 2024;15:1396713
Frontiers in pharmacology 2024;15:1396713
Cystathionine γ-lyase inhibits mitochondrial oxidative stress by releasing H(2)S nearby through the AKT/NRF2 signaling pathway.
Xiao T, Chen S, Yan G, Zheng J, Qiu Q, Lin S, Zong Y, Chang H, Yu Chang AC, Wu Y, Hou C
Frontiers in pharmacology 2024;15:1374720
Frontiers in pharmacology 2024;15:1374720
Identification and validation of potential diagnostic signature and immune cell infiltration for HIRI based on cuproptosis-related genes through bioinformatics analysis and machine learning.
Xiao F, Huang G, Yuan G, Li S, Wang Y, Tan Z, Liu Z, Tomlinson S, He S, Ouyang G, Zeng Y
Frontiers in immunology 2024;15:1372441
Frontiers in immunology 2024;15:1372441
Edaravone dexborneol attenuates oxidative stress in experimental subarachnoid hemorrhage via Keap1/Nrf2 signaling pathway.
Zhu K, Bi S, Zhu Z, Zhang W, Yang X, Li J, Liang G, Yu C, Pan P
Frontiers in pharmacology 2024;15:1342226
Frontiers in pharmacology 2024;15:1342226
NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway.
Sun X, Dong M, Li J, Sun Y, Gao Y, Wang Y, Du L, Liu Y, Ji K, He N, Wang J, Zhang M, Song H, Xu C, Liu Q
Theranostics 2024;14(2):681-698
Theranostics 2024;14(2):681-698
PRMT6-mediated ADMA promotes p62 phase separation to form a negative feedback loop in ferroptosis.
Feng L, Chen L, Wang W, Wei Q, Chen M, Jiang X, Hu S, Wu Y, Duan L, Zhu L, Wang X, Jin H
Theranostics 2024;14(10):4090-4106
Theranostics 2024;14(10):4090-4106
Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway.
Xu L, An T, Jia B, Wu Q, Shen J, Jin J, Liu J, Li C
Burns & trauma 2024;12:tkad062
Burns & trauma 2024;12:tkad062
Quercetin alleviates PM(2.5)-induced chronic lung injury in mice by targeting ferroptosis.
Ding S, Jiang J, Li Y
PeerJ 2024;12:e16703
PeerJ 2024;12:e16703
Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress.
Wang N, Yang H, Chen Y, Wang H, Wang C, Fan J, Chen Y, Li Y, Zhu M
Frontiers in cell and developmental biology 2024;12:1520429
Frontiers in cell and developmental biology 2024;12:1520429
Identification of a novel aromatic-turmerone analog that activates chaperone-mediated autophagy through the persistent activation of p38.
Motomura K, Ueda E, Boateng A, Sugiura M, Kadoyama K, Hitora-Imamura N, Kurauchi Y, Katsuki H, Seki T
Frontiers in cell and developmental biology 2024;12:1418296
Frontiers in cell and developmental biology 2024;12:1418296
Inhibition effect of copper-bearing metals on arterial neointimal hyperplasia via the AKT/Nrf2/ARE pathway in vitro and in vivo.
Wang P, Xu X, Gu G, Guo Q, Rao Y, Yang K, Xi T, Yuan Y, Chen S, Qi X
Regenerative biomaterials 2024;11:rbae042
Regenerative biomaterials 2024;11:rbae042
Antioxidant and anti-inflammatory injectable hydrogel microspheres for in situ treatment of tendinopathy.
Han Q, Bai L, Qian Y, Zhang X, Wang J, Zhou J, Cui W, Hao Y, Yang X
Regenerative biomaterials 2024;11:rbae007
Regenerative biomaterials 2024;11:rbae007
Evaluation the protective role of baicalin against H(2)O(2)-driven oxidation, inflammation and apoptosis in bovine mammary epithelial cells.
Kong X, Wang M, Guo Z, Yang X, Lian H, Gao T, Zhang L, Fu T
Frontiers in veterinary science 2024;11:1504887
Frontiers in veterinary science 2024;11:1504887
Protective effect of short-chain fructo-oligosaccharides from chicory on alcohol-induced injury in GES-1 cells via Keap1/Nrf2 and NLRP3 inflammasome signaling pathways.
Chen Y, Zhao Y, Lu H, Zhang W, Gai Y, Niu G, Meng X, Lv H, Qian X, Ding X, Chen J
Frontiers in nutrition 2024;11:1374579
Frontiers in nutrition 2024;11:1374579
Changes of m(6)A Regulatory Proteins and Nrf2 Signaling Molecules in Liver Tissue of Type 2 Diabetes Mellitus Rats.
Wang N, Yang J, Liu X, Liu G, He Z, Gu S
Cell biochemistry and biophysics 2024 Sep;82(3):2217-2226
Cell biochemistry and biophysics 2024 Sep;82(3):2217-2226
BSA-stabilized selenium nanoparticles ameliorate intracerebral hemorrhage's-like pathology by inhibiting ferroptosis-mediated neurotoxicology via Nrf2/GPX4 axis activation.
Li XN, Lin L, Li XW, Zhu Q, Xie ZY, Hu YZ, Long QS, Wei XB, Wen YQ, Zhang LY, Zhang QK, Jing YC, Wei XH, Li XS
Redox biology 2024 Sep;75:103268
Redox biology 2024 Sep;75:103268
Tangeretin alleviates inflammation and oxidative response induced by spinal cord injury by activating the Sesn2/Keap1/Nrf2 pathway.
Peng B, Hu J, Sun Y, Huang Y, Peng Q, Zhao W, Xu W, Zhu L
Phytotherapy research : PTR 2024 Sep;38(9):4555-4569
Phytotherapy research : PTR 2024 Sep;38(9):4555-4569
UBE2C regulates the KEAP1/NRF2 signaling pathway to promote the growth of gastric cancer by inhibiting autophagy.
Jiang Y, Liu B, Fu L, Li F
International journal of biological macromolecules 2024 Sep;276(Pt 2):134011
International journal of biological macromolecules 2024 Sep;276(Pt 2):134011
Fucoidan alleviates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via Nrf2/GPX4 pathway.
Wang Y, Han J, Zhan S, Guo C, Yin S, Zhan L, Zhou Q, Liu R, Yan H, Wang X, Yan D
International journal of biological macromolecules 2024 Sep;276(Pt 1):133792
International journal of biological macromolecules 2024 Sep;276(Pt 1):133792
STING1-accelerated vascular smooth muscle cell senescence-associated vascular calcification in diabetes is ameliorated by oleoylethanolamide via improved mitochondrial DNA oxidative damage.
Chen Z, Li X, Sun X, Xiao S, Chen T, Ren L, Liu N
Free radical biology & medicine 2024 Sep;222:437-455
Free radical biology & medicine 2024 Sep;222:437-455
Butylphthalide inhibits ferroptosis and ameliorates cerebral Ischaemia-Reperfusion injury in rats by activating the Nrf2/HO-1 signalling pathway.
Sun M, Chen J, Liu F, Li P, Lu J, Ge S, Wang L, Zhang X, Wang X
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Sep;21(5):e00444
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Sep;21(5):e00444
Transcriptional regulation of Znt family members znt4, znt5 and znt10 and their function in zinc transport in yellow catfish (Pelteobagrus fulvidraco).
Liu LL, Song CC, Abu-Elala N, Tan XY, Zhao T, Zheng H, Yang H, Luo Z
Biochimica et biophysica acta. Gene regulatory mechanisms 2024 Sep;1867(3):195041
Biochimica et biophysica acta. Gene regulatory mechanisms 2024 Sep;1867(3):195041
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression.
Abdel-Wahab BA, Zafaar D, Habeeb MS, El-Shoura EAM
British journal of pharmacology 2024 Sep;181(17):3215-3231
British journal of pharmacology 2024 Sep;181(17):3215-3231
Therapeutic effect of nicotinamide mononucleotide on Alzheimer's disease through activating autophagy and anti-oxidative stress.
Ma RY, Li L, Yang H, Zou B, Ma RX, Zhang Y, Wu MM, Chen P, Yao Y, Li J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117199
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117199
Paeonol ameliorates hyperlipidemia and autophagy in mice by regulating Nrf2 and AMPK/mTOR pathways.
Shen B, Wen Y, Li S, Zhou Y, Chen J, Yang J, Zhao C, Wang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155839
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155839
Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs.
Jia CL, Gou Y, Gao Y, Pei X, Jin X, Li BL, Zhang Z, He Y, Ji ES, Zhao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155835
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155835
Cinnamaldehyde alleviates aspirin-induced gastric mucosal injury by regulating pi3k/akt pathway-mediated apoptosis, autophagy and ferroptosis.
Yan S, Bao S, Chen T, Chen J, Zhang J, Hu X, Liang Y, Zhou X, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155791
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155791
Oxysophoridine inhibits oxidative stress and inflammation in hepatic fibrosis via regulating Nrf2 and NF-κB pathways.
Chen JY, Yang YJ, Meng XY, Lin RH, Tian XY, Zhang Y, Lai WF, Yang C, Ma XQ, Huang MQ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155585
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155585
Synthesis, Antioxidant Activity, and Molecular Docking of Novel Paeoniflorin Derivatives.
Ni J, Yang M, Zheng X, Wang M, Xiao Q, Han H, Dong P
Chemical biology & drug design 2024 Sep;104(3):e14629
Chemical biology & drug design 2024 Sep;104(3):e14629
Isoquercetin Ameliorates Osteoarthritis via Nrf2/NF-κB Axis: An In Vitro and In Vivo Study.
Yu H, Lou J, Ni L, Yan M, Zhu K, Mao S, Zhu J
Chemical biology & drug design 2024 Sep;104(3):e14620
Chemical biology & drug design 2024 Sep;104(3):e14620
Quercetin inhibited LPS-induced cytokine storm by interacting with the AKT1-FoxO1 and Keap1-Nrf2 signaling pathway in macrophages.
Xu J, Li Y, Yang X, Li H, Xiao X, You J, Li H, Zheng L, Yi C, Li Z, Huang Y
Scientific reports 2024 Sep 8;14(1):20913
Scientific reports 2024 Sep 8;14(1):20913
Prediction and verification of targets for α-hederin/oxaliplatin dual-loaded rHDL modified liposomes: Reversing effector T-cells dysfunction and improving anti-COAD efficiency in vitro and in vivo.
Wang G, Xu XN, Zhi-Min Z, Wang K, Li F
International journal of pharmaceutics 2024 Sep 5;662:124512
International journal of pharmaceutics 2024 Sep 5;662:124512
Vitamin D receptor alleviates lipid peroxidation in diabetic nephropathy by regulating ACLY/Nrf2/Keap1 pathway.
Zhou Y, Liao Q, Li D, Chen L, Zhang H, Yi B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 30;38(18):e70060
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 30;38(18):e70060
Lycium barbarum berry extract improves female fertility against aging-related oxidative stress in the ovary.
Jiang C, Chen Z, Xiong H, Yang X, Liao W, Chen G, Huang C, Zhu G, Yu H, Ma L
Food & function 2024 Sep 30;15(19):9779-9795
Food & function 2024 Sep 30;15(19):9779-9795
Network Analysis of Gut Microbial Communities Reveals Key Reason for Quercetin Protects against Colitis.
Lv Y, Peng J, Ma X, Liang Z, Salekdeh GH, Ke Q, Shen W, Yan Z, Li H, Wang S, Ding X
Microorganisms 2024 Sep 29;12(10)
Microorganisms 2024 Sep 29;12(10)
Aldo-Keto reductase 1C3 reduces myocardial cell damage after acute myocardial infarction by activating the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response element pathway to inhibit ferroptosis.
Miao W, Hu YZ
Journal of geriatric cardiology : JGC 2024 Sep 28;21(9):899-912
Journal of geriatric cardiology : JGC 2024 Sep 28;21(9):899-912
Activation of GABA(B)R Attenuates Intestinal Inflammation by Reducing Oxidative Stress through Modulating the TLR4/MyD88/NLRP3 Pathway and Gut Microbiota Abundance.
Deng Z, Li D, Wang L, Lan J, Wang J, Ma Y
Antioxidants (Basel, Switzerland) 2024 Sep 21;13(9)
Antioxidants (Basel, Switzerland) 2024 Sep 21;13(9)
MMP9 drives ferroptosis by regulating GPX4 and iron signaling.
Gawargi FI, Mishra PK
iScience 2024 Sep 20;27(9):110622
iScience 2024 Sep 20;27(9):110622
The BRD4 Inhibitor I-BET-762 Reduces HO-1 Expression in Macrophages and the Pancreas of Mice.
Leal AS, Liby KT
International journal of molecular sciences 2024 Sep 16;25(18)
International journal of molecular sciences 2024 Sep 16;25(18)
NBQX mediates ventricular fibrillation susceptibility in rat models of anxiety via the Nrf2/HO-1 pathway.
Hu Y, Qu C, Zou Y, Liu X, Zhang C, Yang B
Heliyon 2024 Sep 15;10(17):e37358
Heliyon 2024 Sep 15;10(17):e37358
Time of day-dependent alterations of ferroptosis in LPS-induced myocardial injury via Bmal-1/AKT/ Nrf2 in rat and H9c2 cell.
Ying-Hao P, Yu-Shan Y, Song-Yi C, Hua J, Peng Y, Xiao-Hu C
Heliyon 2024 Sep 15;10(17):e37088
Heliyon 2024 Sep 15;10(17):e37088
LFHP-1c improves cognitive function after TBI in mice by reducing oxidative stress through the PGAM5-NRF2-KEAP1 ternary complex.
Shao W, Wang JJ, Niu ZH, Zhang K, Wang S, Wang YH, Tang YH, Wang CC, Hou SQ, Zhou DR, Zhang C, Lin N
Heliyon 2024 Sep 15;10(17):e36820
Heliyon 2024 Sep 15;10(17):e36820
SIRT6 alleviates senescence induced by Porphyromonas gingivalis in human gingival fibroblasts.
Shi J, Hao XY, Tong Y, Qian WB, Sun Y
Molecular biology reports 2024 Sep 11;51(1):976
Molecular biology reports 2024 Sep 11;51(1):976
Itaconic Acid Alleviates Perfluorooctanoic Acid-Induced Oxidative Stress and Intestinal Damage by Regulating the Keap1/Nrf2/Ho-1 Pathway and Reshaping the Gut Microbiota.
Wu L, Hu Z, Luo X, Ge C, Lv Y, Zhan S, Huang W, Shen X, Yu D, Liu B
International journal of molecular sciences 2024 Sep 11;25(18)
International journal of molecular sciences 2024 Sep 11;25(18)
Dietary nitrate maintains homeostasis of oxidative stress and gut microbiota to promote flap survival in type 2 diabetes mellitus rats.
Niu Q, Li D, Guo W, Feng Z, Han Z, Yang Y
BMC endocrine disorders 2024 Sep 10;24(1):184
BMC endocrine disorders 2024 Sep 10;24(1):184
tBHQ mitigates fatty liver ischemia-reperfusion injury by activating Nrf2 to attenuate hepatocyte mitochondrial damage and macrophage STING activation.
Wu D, Xu J, Zhang Y, Wang Y, Bai Y, Zhan X, Gao Y, Zhou H, Hu H, Wang P, Rao Z
International immunopharmacology 2024 Sep 10;138:112515
International immunopharmacology 2024 Sep 10;138:112515
Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis.
Tan Q, Yang H, He Y, Shen X, Sun L, Du X, Lin G, Zhou N, Wang N, Zhou Q, Liu D, Xu X, Zhao L, Xie P
Journal of medical virology 2024 Oct;96(10):e29945
Journal of medical virology 2024 Oct;96(10):e29945
Apo-12'-capsorubinal exhibits anti-inflammatory effects and activates nuclear factor erythroid 2-related factor 2 in RAW264.7 macrophages.
Takatani N, Miyafusa H, Yamano Y, Beppu F, Hosokawa M
Archives of biochemistry and biophysics 2024 Oct;760:110125
Archives of biochemistry and biophysics 2024 Oct;760:110125
Phytic acid-loaded polyvinyl alcohol hydrogel promotes wound healing of injured corneal epithelium through inhibiting ferroptosis.
Gong D, Wu N, Chen H, Zhang W, Yan C, Zhang C, Fu Y, Sun H
Redox biology 2024 Oct;76:103354
Redox biology 2024 Oct;76:103354
Resveratrol Ameliorates Retinal Ischemia-Reperfusion Injury by Modulating the NLRP3 Inflammasome and Keap1/Nrf2/HO-1 Signaling Pathway.
Feng J, Ji K, Pan Y, Huang P, He T, Xing Y
Molecular neurobiology 2024 Oct;61(10):8454-8466
Molecular neurobiology 2024 Oct;61(10):8454-8466
Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia.
Zhang Y, Che N, Wang S, Meng J, Zhao N, Han J, Dong X, Li Y, Mo J, Zhao X, Liu T
Journal of gastroenterology 2024 Oct;59(10):941-957
Journal of gastroenterology 2024 Oct;59(10):941-957
Cytochrome P450 F3 promotes colorectal cancer via inhibiting NRF2-mediated ferroptosis.
Xu Z, Xu C, Lu J, He C, Wang X, Zhu D, Wang A, Zhang Z, Jiang C
Translational oncology 2024 Oct;48:102077
Translational oncology 2024 Oct;48:102077
Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway.
Zhao Y, He C, Hu S, Ni H, Tan X, Zhi Y, Yi L, Na R, Li Y, Du Q, Li QX, Dong Y
Experimental neurology 2024 Oct;380:114881
Experimental neurology 2024 Oct;380:114881
Berberine Inhibits Ferroptosis and Stabilizes Atherosclerotic Plaque through NRF2/SLC7A11/GPX4 Pathway.
Wang TT, Yu LL, Zheng JM, Han XY, Jin BY, Hua CJ, Chen YS, Shang SS, Liang YZ, Wang JR
Chinese journal of integrative medicine 2024 Oct;30(10):906-916
Chinese journal of integrative medicine 2024 Oct;30(10):906-916
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator-activated receptor gamma.
Qin J, Zhao Y, Li S, Liu Q, Huang S, Yu X
The FEBS journal 2024 Oct;291(20):4581-4601
The FEBS journal 2024 Oct;291(20):4581-4601
Prebiotic stachyose inhibits PRDX5 activity and castration-resistant prostate cancer development.
Wang R, Pan Y, Zhang L, Wang J, Ni J, Ding Y, Wang S, Yin J, Ding L, Ran X, Fan S, Sun Q, Tan SY, Koeffler HP, Li J, Mi Y, Chen YQ
International journal of biological macromolecules 2024 Oct;278(Pt 3):134844
International journal of biological macromolecules 2024 Oct;278(Pt 3):134844
7,8-DHF inhibits BMSC oxidative stress via the TRKB/PI3K/AKT/NRF2 pathway to improve symptoms of postmenopausal osteoporosis.
Li D, Zhao Z, Zhu L, Feng H, Song J, Fu J, Li J, Chen Z, Fu H
Free radical biology & medicine 2024 Oct;223:413-429
Free radical biology & medicine 2024 Oct;223:413-429
Thiols-rich peptide from water buffalo horn keratin alleviates oxidative stress and inflammation through co-regulating Nrf2/Hmox-1 and NF-κB signaling pathway.
Wu W, Tang J, Bao W, Feng Q, Zheng J, Hong M, Guo S, Zhu Y, Huang S, Zhao M, Duan JA, Liu R
Free radical biology & medicine 2024 Oct;223:131-143
Free radical biology & medicine 2024 Oct;223:131-143
PLK2-mediated phosphorylation of SQSTM1 S349 promotes aggregation of polyubiquitinated proteins upon proteasomal dysfunction.
Chen YD, Lin XP, Ruan ZL, Li M, Yi XM, Zhang X, Li S, Shu HB
Autophagy 2024 Oct;20(10):2221-2237
Autophagy 2024 Oct;20(10):2221-2237
Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway.
Pan F, Yang W, Zhao T, Liu K, Zhao S, Zhao L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114908
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114908
Wnt/β-catenin signaling inhibits oxidative stress-induced ferroptosis to improve interstitial cystitis/bladder pain syndrome by reducing NF-κB.
Fang W, Song X, Li H, Meng F, Lv T, Huang J, Ji X, Lv J, Cai Z, Wang Z
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119766
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119766
Bombesin protects myocardium against ischemia/reperfusion injury via activation of the Keap1-Nrf2-HO-1 signaling pathway.
Zhang J, Du Y, Xiong Z, Cheng H, Du Y, Xiong Y, Lv J, Huang W, Qiu K, Zhang S
Peptides 2024 Oct;180:171279
Peptides 2024 Oct;180:171279
Sulforaphane improves post-resuscitation myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the Nrf2/IRF1/GPX4 pathway.
Zheng Z, Xu J, Mao Y, Mei Z, Zhu J, Lan P, Wu X, Xu S, Zhang M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117408
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117408
Propofol pretreatment inhibits ferroptosis and alleviates myocardial ischemia-reperfusion injury through the SLC16A13-AMPK-GPX4 pathway.
Sun F, He Y, Yang Z, Xu G, Wang R, Juan Z, Sun X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117345
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117345
Artemether ameliorates acetaminophen-induced liver injury through Nrf2 pathway.
Yu S, Yang N, Li H, Hu X, Zhang L, Li S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117280
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117280
Ganweikang extract protects hepatocytes from oxidative injury by activating Nrf2/HO-1 and MAPKs pathways.
Xiao L, Zhao M, Linghu KG, Wu G, Zhang T, Chen C, Guan J, Cao Z, Hu Y, Yu H
Fitoterapia 2024 Oct;178:106146
Fitoterapia 2024 Oct;178:106146
The effects of BMP2 and the mechanisms involved in the invasion and angiogenesis of IDH1 mutant glioma cells.
Xu H, Cao Y, Ruan J, Wang F, He Y, Yang L, Yu T, Du F, Zhang N, Cao X
Journal of neuro-oncology 2024 Oct;170(1):161-171
Journal of neuro-oncology 2024 Oct;170(1):161-171
Liver protects neuron viability and electrocortical activity in post-cardiac arrest brain injury.
Guo Z, Yin M, Sun C, Xu G, Wang T, Jia Z, Zhang Z, Zhu C, Zheng D, Wang L, Huang S, Liu D, Zhang Y, Xie R, Gao N, Zhan L, He S, Zhu Y, Li Y, Nashan B, Andrea S, Xu J, Zhao Q, He X
EMBO molecular medicine 2024 Oct;16(10):2322-2348
EMBO molecular medicine 2024 Oct;16(10):2322-2348
Schisandra chinensis lignans regulate and cooperate with endogenous cannabinoid systems to ameliorate intestinal barrier injury associated with depression.
Wang J, Zheng A, Lin F, Zhang X, Shi K, Yan T, Jia Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155929
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155929
Phenylpropanoid-rich maize root extract serves as a natural antidepressant.
Zhong T, Zhang Y, Yang H, Luo F, Xu Y, Fan Y, Liu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155893
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155893
Nrf2 deficiency exacerbated pulmonary pyroptosis in maternal hypoxia-induced intrauterine growth restriction offspring mice.
Chen D, Man LY, Wang YY, Zhu WY, Zhao HM, Li SP, Zhang YL, Li SC, Wu YX, Ling-Ai, Pang QF
Reproductive toxicology (Elmsford, N.Y.) 2024 Oct;129:108671
Reproductive toxicology (Elmsford, N.Y.) 2024 Oct;129:108671
Human umbilical cord mesenchymal stem cells-derived exosomes attenuate burn-induced acute lung injury via inhibiting ferroptosis.
Li L, Song QQ, Li SR, Jia ZG, Sun XC, Zhao YT, Deng JB, Wu JJ, Ni T, Liu JS
Acta histochemica 2024 Oct;126(5-7):152189
Acta histochemica 2024 Oct;126(5-7):152189
Orientin promotes diabetic wounds healing by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
Yang JY, Zhuang C, Lin YZ, Yu YT, Zhou CC, Zhang CY, Zhu ZT, Qian CJ, Zhou YN, Zheng WH, Zhao Y, Jin C, Wu ZY
Food science & nutrition 2024 Oct;12(10):7461-7480
Food science & nutrition 2024 Oct;12(10):7461-7480
4-Octyl itaconate promotes alveolar ridge preservation following tooth extraction.
Du Y, He Y, Xie J, Wang Y, Sun X, Yu X
Odontology 2024 Oct;112(4):1069-1079
Odontology 2024 Oct;112(4):1069-1079
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Gao X, Fu S, Wen J, Yan A, Yang S, Zhang Y, Liu D, He D
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac Injury through Maintaining SLC25A10-Mediated Mitochondrial Glutathione Import.
Xu T, Chen G
International journal of molecular sciences 2024 Oct 9;25(19)
International journal of molecular sciences 2024 Oct 9;25(19)
Dietary ferulic acid supplementation enhances antioxidant capacity and alleviates hepatocyte pyroptosis in diquat challenged piglets.
Luo J, Wu X, Chen D, Yu B, He J
Journal of animal science and biotechnology 2024 Oct 7;15(1):134
Journal of animal science and biotechnology 2024 Oct 7;15(1):134
Ozone therapy mitigates parthanatos after ischemic stroke.
Li J, Liu X, Wang Z, Xie P, Zhu M, Zhong H, Luo S, Tang J, Mo G
Biological research 2024 Oct 5;57(1):71
Biological research 2024 Oct 5;57(1):71
Wogonin mitigates acetaminophen-induced liver injury in mice through inhibition of the PI3K/AKT signaling pathway.
Zhao W, Luo H, Lin Z, Huang L, Pan Z, Chen L, Fan L, Yang S, Tan H, Zhong C, Liu H, Huang C, Wang J, Zhang B
Journal of ethnopharmacology 2024 Oct 5;332:118364
Journal of ethnopharmacology 2024 Oct 5;332:118364
ML385, an Nrf2 Inhibitor, Synergically Enhanced Celastrol Triggered Endoplasmic Reticulum Stress in Lung Cancer Cells.
Xu C, Chen Y, Zhou Z, Yan Y, Fu W, Zou P, Ni D
ACS omega 2024 Oct 29;9(43):43697-43705
ACS omega 2024 Oct 29;9(43):43697-43705
Antioxidant 1,2,3,4,6-Penta-O-galloyl-β-D-glucose Alleviating Apoptosis and Promoting Bone Formation Is Associated with Estrogen Receptors.
Hua Y, Wang H, Chen T, Zhou Y, Chen Z, Zhao X, Mo S, Mao H, Li M, Wang L, Hong M
Molecules (Basel, Switzerland) 2024 Oct 29;29(21)
Molecules (Basel, Switzerland) 2024 Oct 29;29(21)
Essential oil from Chimonanthus nitens Oliv. Leaves ameliorate inflammation and oxidative stress in LPS-induced ALI through NF-κB and Nrf2 signaling pathways.
Gao B, Qian X, Guo Y, Dong W, Yang M, Yang H, Huang X, Liang X
Journal of ethnopharmacology 2024 Oct 28;333:118470
Journal of ethnopharmacology 2024 Oct 28;333:118470
Ellagic Acid Reduces Cadmium Exposure-Induced Apoptosis in HT22 Cells via Inhibiting Oxidative Stress and Mitochondrial Dysfunction and Activating Nrf2/HO-1 Pathway.
Liu Y, Chen C, Hao Z, Shen J, Tang S, Dai C
Antioxidants (Basel, Switzerland) 2024 Oct 25;13(11)
Antioxidants (Basel, Switzerland) 2024 Oct 25;13(11)
The Protective Effects of Polygala tenuifolia and Tenuifolin on Corticosterone-Evoked Ferroptosis, Oxidative Stress, and Neuroinflammation: Insights from Molecular Dynamics Simulations and In Vitro Experiments.
Xue C, He Z, Zeng M, Wang Z, Chen Q, Qin F, Chen M, Ye H, Chen J
Foods (Basel, Switzerland) 2024 Oct 23;13(21)
Foods (Basel, Switzerland) 2024 Oct 23;13(21)
Tetramethylpyrazine Analogue T-006 Protects Neuronal and Endothelial Cells Against Oxidative Stress via PI3K/AKT/mTOR and Nrf2 Signaling.
Zhang G, Liang Z, Wang Y, Zhang Z, Hoi PM
Antioxidants (Basel, Switzerland) 2024 Oct 21;13(10)
Antioxidants (Basel, Switzerland) 2024 Oct 21;13(10)
Role of iron homeostasis in the mutagenicity of disinfection by-products in mammalian cells.
Zhou Y, Liu Y, Wang T, Li H, He J, Xu A
Ecotoxicology and environmental safety 2024 Oct 15;285:117122
Ecotoxicology and environmental safety 2024 Oct 15;285:117122
Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study.
Zhuang LG, Zhang R, Jin GX, Pei XY, Wang Q, Ge XX
World journal of diabetes 2024 Oct 15;15(10):2111-2122
World journal of diabetes 2024 Oct 15;15(10):2111-2122
CD8+ T cell associated scoring model helps prognostic diagnosis and immunotherapy selection in patients with colon adenocarcinoma.
Zhao Z, Chen M, Sun K, Gu X
Heliyon 2024 Oct 15;10(19):e37998
Heliyon 2024 Oct 15;10(19):e37998
Mitochondrial disruption resulting from Cepharanthine-mediated TOM inhibition triggers ferroptosis in colorectal cancer cells.
Li LG, Zhang D, Huang Q, Yan M, Chen NN, Yang Y, Xiao RC, Liu H, Han N, Qureshi AM, Hu J, Leng F, Hui YJ
Journal of cancer research and clinical oncology 2024 Oct 14;150(10):460
Journal of cancer research and clinical oncology 2024 Oct 14;150(10):460
Comparative Study of an Antioxidant Compound and Ethoxyquin on Feed Oxidative Stability and on Performance, Antioxidant Capacity, and Intestinal Health in Starter Broiler Chickens.
Xiao Y, Gao X, Yuan J
Antioxidants (Basel, Switzerland) 2024 Oct 13;13(10)
Antioxidants (Basel, Switzerland) 2024 Oct 13;13(10)
Licochalcone A Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load and Activating the Nrf2/HO-1 Signaling Pathway.
Tian Y, Luan J, Wang Q, Li C, Peng X, Jiang N, Zhao G, Lin J
ACS infectious diseases 2024 Oct 11;10(10):3516-3527
ACS infectious diseases 2024 Oct 11;10(10):3516-3527
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice.
Zhang Y, Zhang C, Dai Q, Ma R
Neuromolecular medicine 2024 Oct 10;26(1):40
Neuromolecular medicine 2024 Oct 10;26(1):40
Rituximab induces ferroptosis and RSL3 overcomes rituximab resistance in diffuse large B-cell lymphoma cells.
Wu H, Zou L, Jin Y, Wang G, Cho WC, Li W, Cai Y, Song G
Archives of biochemistry and biophysics 2024 Nov;761:110188
Archives of biochemistry and biophysics 2024 Nov;761:110188
Treatment with a combination of myricitrin and exercise alleviates myocardial infarction in rats via suppressing Nrf2/HO-1 antioxidant pathway.
Qu FX, Guo X, Liu XJ, Zhang SW, Xin Y, Li JY, Wang R, Xu CJ, Li HY, Lu CH
Archives of biochemistry and biophysics 2024 Nov;761:110153
Archives of biochemistry and biophysics 2024 Nov;761:110153
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury.
Zhang B, Yu J, Bao L, Feng D, Qin Y, Fan D, Hong X, Chen Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Nov;73(11):1981-1994
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Nov;73(11):1981-1994
The single-cell transcriptomic landscape of the topological differences in mammalian auditory receptors.
Ma X, Chen X, Che Y, Zhu S, Wang X, Gao S, Wu J, Kong F, Cheng C, Wu Y, Guo J, Qi J, Chai R
Science China. Life sciences 2024 Nov;67(11):2398-2410
Science China. Life sciences 2024 Nov;67(11):2398-2410
Nrf2 deficiency in muscle attenuates experimental autoimmune myositis-induced muscle weakness.
Himori K, Yamada M, Onoki T, Matsumaru D, Motohashi H, Okutsu M
The Journal of physiology 2024 Nov;602(22):6189-6207
The Journal of physiology 2024 Nov;602(22):6189-6207
CBR-470-1 protects against cardiomyocyte death in ischaemia/reperfusion injury by activating the Nrf2-GPX4 cascade.
Qiu ZY, Shi KN, Li HH, Zhang B
Toxicology and applied pharmacology 2024 Nov;492:117113
Toxicology and applied pharmacology 2024 Nov;492:117113
HADH suppresses clear cell renal cell carcinoma progression through reduced NRF2-dependent glutathione synthesis.
Chu C, Liu S, He Z, Wu M, Xia J, Zeng H, Xie W, Cheng R, Zhao X, Li X
Translational oncology 2024 Nov;49:102112
Translational oncology 2024 Nov;49:102112
A two-pronged approach to inhibit ferroptosis of MSCs caused by the iron overload in postmenopausal osteoporosis and promote osseointegration of titanium implant.
Yang Y, Zhang X, Yang Y, Gao P, Fan W, Zheng T, Yang W, Tang Y, Cai K
Bioactive materials 2024 Nov;41:336-354
Bioactive materials 2024 Nov;41:336-354
Silver Nanoparticles Loaded With Oleuropein Alleviates LPS-Induced Acute Lung Injury by Modulating the TLR4/P2X7 Receptor-Mediated Inflammation and Apoptosis in Rats.
Yakut S, Gelen V, Kara H, Özkanlar S, Yeşildağ A
Environmental toxicology 2024 Nov;39(11):4960-4973
Environmental toxicology 2024 Nov;39(11):4960-4973
Ferulic Acid Protects Human Lens Epithelial Cells Against UVA-Induced Oxidative Damage by Downregulating the DNA Demethylation of the Keap1 Promoter.
Ling X, Zhu L, Yan Y, Qian H, Kang Z, Ye W, Xie Z, Xue C
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70031
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70031
Ginkgo Flavone Aglycone Ameliorates Atherosclerosis via Inhibiting Endothelial Pyroptosis by Activating the Nrf2 Pathway.
Chen X, Yang Z, Liao M, Zhao Q, Lu Y, Li Q, Liu S, Li S, Chen J, He Y
Phytotherapy research : PTR 2024 Nov;38(11):5458-5473
Phytotherapy research : PTR 2024 Nov;38(11):5458-5473
Mechanical Stress-Oxidative Stress Axis: Biological Basis in the Vaginal Wall and Pelvic Floor Muscles of Rats with Simulated Birth Injury.
Wang Q, Wu X, Wang S, Xie B, Sun X, Wang J
International urogynecology journal 2024 Nov;35(11):2141-2152
International urogynecology journal 2024 Nov;35(11):2141-2152
Metformin attenuates PM(2.5)-induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells.
Cui J, Chen W, Zhang D, Lu M, Huang Z, Yi B
Toxicology mechanisms and methods 2024 Nov;34(9):1022-1034
Toxicology mechanisms and methods 2024 Nov;34(9):1022-1034
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
Fang M, Yu Q, Ou J, Lou J, Zhu J, Lin Z
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
Lycium barbarum polysaccharides (LBP) suppresses hypoxia/reoxygenation (H/R)-induced rat H9C2 cardiomyocytes pyroptosis via Nrf2/HO-1 signaling pathway.
Gao Y, Li H, Que Y, Chen W, Huang SY, Liu W, Ye X
International journal of biological macromolecules 2024 Nov;280(Pt 4):135924
International journal of biological macromolecules 2024 Nov;280(Pt 4):135924
Hepatocyte-Specific HuR Protects Against Acetaminophen-Induced Liver Injury in Mice.
Lu L, Chen J, Jiang H, Li N, Li X, Liu Y, Zong C
Journal of cellular and molecular medicine 2024 Nov;28(22):e70246
Journal of cellular and molecular medicine 2024 Nov;28(22):e70246
Oleocanthal mitigates CoCl(2)-induced oxidative damage and apoptosis via regulating MAPK pathway in human retinal pigment epithelial cells.
Huang KC, Chiang YF, Ali M, Hsia SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117582
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117582
Buparlisib and ponatinib inhibit aggressiveness of cholangiocarcinoma cells via suppression of IRS1-related pathway by targeting oxidative stress resistance.
Kaewlert W, Sakonsinsiri C, Lert-Itthiporn W, Mahalapbutr P, Ali S, Rungrotmongkol T, Jusakul A, Armartmuntree N, Pairojkul C, Feng G, Ma N, Pinlaor S, Murata M, Thanan R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117569
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117569
APMCG-1 attenuates ischemic stroke injury by reducing oxidative stress and apoptosis and promoting angiogenesis via activating PI3K/AKT pathway.
He X, Wu M, Chen L, Liu M, Hu X, Meng Y, Yue H, Yang X, Zheng P, Dai Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117506
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117506
Effects of diet-induced metabolic syndrome on cardiac function and angiogenesis in response to the sodium-glucose cotransporter-2 inhibitor canagliflozin.
Harris DD, Broadwin M, Sabe SA, Stone C, Kanuparthy M, Nho JW, Bellam K, Banerjee D, Abid MR, Sellke FW
The Journal of thoracic and cardiovascular surgery 2024 Nov;168(5):e183-e199
The Journal of thoracic and cardiovascular surgery 2024 Nov;168(5):e183-e199
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model.
Du M, Fu J, Zhang J, Zhu Z, Huang X, Tan W, Liu L, Huang Z, Liu X, Tan Q, Liao Z, Cheng Y
Clinical and translational medicine 2024 Nov;14(11):e70100
Clinical and translational medicine 2024 Nov;14(11):e70100
Mn(II)-Aloe-Emodin Nanoscale Coordination Polymer Enhances Ferroptosis by Synergistically Enhancing Reactive Oxygen Species Generation via the Nrf2-GPX4 Axis.
Yang X, Li C, Ge M, Li X, Zhao W, Guo H, Nie H, Liu J
Advanced healthcare materials 2024 Nov;13(28):e2400474
Advanced healthcare materials 2024 Nov;13(28):e2400474
Human placental mesenchymal stromal cells alleviate intestinal oxidative damage in mice with graft-versus-host disease via CD73/adenosine/PI3K/Akt/GSK-3β axis.
Han K, Wang F, Ma X, Wu Y, Zhang H, Zhao Y, Wang H, Ma J, Luan X
Cellular signalling 2024 Nov;123:111372
Cellular signalling 2024 Nov;123:111372
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Wang Y, Yang Y, Cai Y, Aobulikasimu A, Wang Y, Hu C, Miao Z, Shao Y, Zhao M, Hu Y, Xu C, Chen X, Li Z, Chen J, Wang L, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Oxidised rice bran oil induced oxidative stress and apoptosis in IPEC-J2 cells via the Nrf2 signalling pathway.
Wang R, Wang C, Chen P, Qi H, Zhang J
Journal of animal physiology and animal nutrition 2024 Nov;108(6):1844-1855
Journal of animal physiology and animal nutrition 2024 Nov;108(6):1844-1855
ML385 promotes ferroptosis and radiotherapy sensitivity by inhibiting the NRF2-SLC7A11 pathway in esophageal squamous cell carcinoma.
Yan L, Hu H, Feng L, Li Z, Zheng C, Zhang J, Yin X, Li B
Medical oncology (Northwood, London, England) 2024 Nov 7;41(12):309
Medical oncology (Northwood, London, England) 2024 Nov 7;41(12):309
GDF15 attenuates sepsis-induced myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the SOCS1/GPX4 signaling pathway.
Li X, Sun H, Zhang L, Liang H, Zhang B, Yang J, Peng X, Sun J, Zhou Y, Zhai M, Jiang L, Zhu H, Duan W
European journal of pharmacology 2024 Nov 5;982:176894
European journal of pharmacology 2024 Nov 5;982:176894
cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy.
Huang Y, Wang L, Jin H
Investigative ophthalmology & visual science 2024 Nov 4;65(13):55
Investigative ophthalmology & visual science 2024 Nov 4;65(13):55
The Effect of Meloxicam on Inflammatory Response and Oxidative Stress Induced by Klebsiella pneumoniae in Bovine Mammary Epithelial Cells.
Liu K, Qiu S, Fang L, Cui L, Dong J, Guo L, Meng X, Li J, Wang H
Veterinary sciences 2024 Nov 29;11(12)
Veterinary sciences 2024 Nov 29;11(12)
Ciprofol prevents ferroptosis in LPS induced acute lung injury by activating the Nrf2 signaling pathway.
Zhao Q, Kong C, Wu X, Ling Y, Shi J, Li S, Zhu Y, Yu J
BMC pulmonary medicine 2024 Nov 28;24(1):591
BMC pulmonary medicine 2024 Nov 28;24(1):591
Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion.
Liu D, Zhu Y
Cells 2024 Nov 28;13(23)
Cells 2024 Nov 28;13(23)
Oncogenic RTKs sensitize cancer cells to ferroptosis via c-Myc mediated upregulation of ACSL4.
Sun N, Wang J, Qin J, Ma S, Luan J, Hou G, Zhang W, Gao M
Cell death & disease 2024 Nov 27;15(11):861
Cell death & disease 2024 Nov 27;15(11):861
Trehalose Alleviates D-Galactose-Induced Aging-Related Granulosa Cell Death in Ovaries.
Xi H, Chen X, Liang K, Wang X, Jiang F, Li Y, Niu D
International journal of molecular sciences 2024 Nov 25;25(23)
International journal of molecular sciences 2024 Nov 25;25(23)
Increased splicing of CXCR3 isoform B (CXCR3B) by impaired NRF2 signaling leads to melanocyte apoptosis in active vitiligo.
Le Y, Geng MM, Dong BQ, Luo LF, Jiang S, Le Poole IC, Lei TC
Free radical biology & medicine 2024 Nov 20;225:687-698
Free radical biology & medicine 2024 Nov 20;225:687-698
Renal microRNA-144-3p is associated with transforming growth factor-β1-induced oxidative stress and fibrosis by suppressing the NRF2 pathway in hypertensive diabetic kidney disease.
Kim SK, Bae GS, Bae T, Ku SK, Choi BH, Kwak MK
Free radical biology & medicine 2024 Nov 20;225:546-559
Free radical biology & medicine 2024 Nov 20;225:546-559
Mesenchymal stromal cells deliver H(2)S-enhanced Nrf2 via extracellular vesicles to mediate mitochondrial homeostasis for repairing hypoxia-ischemia brain damage.
Gai C, Li T, Zhao Y, Cheng Y, Song Y, Luo Q, Liu D, Wang Z
Free radical biology & medicine 2024 Nov 20;225:528-545
Free radical biology & medicine 2024 Nov 20;225:528-545
Therapeutic potential of plasma-treated solutions in atopic dermatitis.
Yin T, Feng S, Zhu H, Bai R, Gan X, He K, Du W, Cheng B, Liu X, Wang Z, Zhang H, Zheng Y, Liu D
Free radical biology & medicine 2024 Nov 20;225:482-493
Free radical biology & medicine 2024 Nov 20;225:482-493
Biliverdin improved angiogenesis and suppressed apoptosis via PI3K/Akt-mediated Nrf2 antioxidant system to promote ischemic flap survival.
Yao Z, Xue K, Chen J, Zhang Y, Zhang G, Zheng Z, Li Z, Li Z, Wang F, Sun X, Shen L, Mao C, Lin C
Free radical biology & medicine 2024 Nov 20;225:35-52
Free radical biology & medicine 2024 Nov 20;225:35-52
Therapeutic potential of omaveloxolone in counteracting muscle atrophy post-denervation: a multi-omics approach.
Wang S, Yang X, Liu K, Xiong D, Yalikun A, Hamiti Y, Yusufu A
Journal of translational medicine 2024 Nov 2;22(1):991
Journal of translational medicine 2024 Nov 2;22(1):991
Tripartite motif 25 inhibits protein aggregate degradation during PRRSV infection by suppressing p62-mediated autophagy.
Ren J, Pei Q, Dong H, Wei X, Li L, Duan H, Zhang G, Zhang A
Journal of virology 2024 Nov 19;98(11):e0143724
Journal of virology 2024 Nov 19;98(11):e0143724
Asperuloside activates hepatic NRF2 signaling to stimulate mitochondrial metabolism and restore lipid homeostasis in high fat diet-induced MAFLD.
He C, Zhang Q, Zhu R, Tse G, Wong WT
European journal of pharmacology 2024 Nov 15;983:177003
European journal of pharmacology 2024 Nov 15;983:177003
Cobalt nanoparticles attenuate microplastic-induced vascular endothelial injury via Nrf2 pathway activation.
Deng L, Li M, Jiang Z, Xiang G, He S, Zhang H, Deng A, Wang Y
The Science of the total environment 2024 Nov 15;951:175711
The Science of the total environment 2024 Nov 15;951:175711
Trimethylamine Induced Chronic Kidney Injury by Activating the ZBP1-NLRP3 Inflammasome Pathway.
Bai L, Chen Q, Li Y, Wu F, Jin M, Chen Y, Teng X, Jin S, Fan H, Wu Y
Physiological research 2024 Nov 15;73(5):779-789
Physiological research 2024 Nov 15;73(5):779-789
Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis.
Xu Z, Wang Y, Yang W, Han W, Ma B, Zhao Y, Bao T, Zhang Q, Lin X
Journal of ethnopharmacology 2024 Nov 15;334:118582
Journal of ethnopharmacology 2024 Nov 15;334:118582
Design, synthesis and biological evaluation of N-salicyloyl tryptamine derivatives as multifunctional neuroprotectants for the treatment of ischemic stroke.
Wu G, Li B, Wei X, Chen Y, Zhao Y, Peng Y, Su J, Hu Z, Zhuo L, Tian Y, Wang Z, Peng X
European journal of medicinal chemistry 2024 Nov 15;278:116795
European journal of medicinal chemistry 2024 Nov 15;278:116795
Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-κB and Nrf2 signaling pathways.
Ma J, Wang Z, Sun Y, Zheng R, Tan H, Zhang H, Jin Z, Wu Y, Sun Z
International immunopharmacology 2024 Nov 15;141:112960
International immunopharmacology 2024 Nov 15;141:112960
SIRT5 participates in the suppressive tumor immune microenvironment of EGFR-mutant LUAD by regulating the succinylation of ACAT1.
Shouhan W, Qingchang L, Xiaodan S
Heliyon 2024 Nov 15;10(21):e39743
Heliyon 2024 Nov 15;10(21):e39743
Dexmedetomidine preconditioning attenuates ferroptosis in myocardial ischemia-reperfusion injury via α2 adrenergic receptor activation.
Wang M, Ren Z, Sun X, Li Y, Chen Z
Heliyon 2024 Nov 15;10(21):e39697
Heliyon 2024 Nov 15;10(21):e39697
Discovery of Propionic Acid Derivatives with a 5-THIQ Core as Potent and Orally Bioavailable Keap1-Nrf2 Protein-Protein Interaction Inhibitors for Acute Kidney Injury.
Shi Z, Zhang Y, Wang X, Tang J, Kang Y, Hu J, Li L, Yang B, Chen S, Xiao Q, Lan J, Hu J, Peng Y, Yin D
Journal of medicinal chemistry 2024 Nov 14;67(21):19247-19266
Journal of medicinal chemistry 2024 Nov 14;67(21):19247-19266
osa-miR168a, a Plant miRNA That Survives the Process of In Vivo Food Digestion, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice by Oral Administration.
Xu Q, Li Y, Qin X, Xin Y, Wang J, Zhang Y, Xu K, Yang X, Wang X
Journal of agricultural and food chemistry 2024 Nov 13;72(45):25146-25160
Journal of agricultural and food chemistry 2024 Nov 13;72(45):25146-25160
Protective role of aconitate decarboxylase 1 in neuroinflammation-induced dysfunctions of the paraventricular thalamus and sleepiness.
Chang J, Li Z, Yuan H, Wang X, Xu J, Yang P, Qin L
Communications biology 2024 Nov 10;7(1):1484
Communications biology 2024 Nov 10;7(1):1484
Loss of Nrf2 aggravates ionizing radiation-induced intestinal injury by activating the cGAS/STING pathway via Pirin.
Xu Y, Wang L, Liao H, Li X, Zhang Y, Chen X, Xu B, Liu Y, Tu W, Liu Y
Cancer letters 2024 Nov 1;604:217218
Cancer letters 2024 Nov 1;604:217218
Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoids in lipopolysaccharide-treated HEI-OC1 cells through modulation of the FOXP3/Nrf2 signaling pathway.
Li J, Zhu X, Ye S, Dong Q, Hou J, Liu J, She W
Acta biochimica et biophysica Sinica 2024 Nov 1;57(5):727-737
Acta biochimica et biophysica Sinica 2024 Nov 1;57(5):727-737
Treatment of Parkinson's disease model with human umbilical cord mesenchymal stem cell-derived exosomes loaded with BDNF.
Wang CC, Hu XM, Long YF, Huang HR, He Y, Xu ZR, Qi ZQ
Life sciences 2024 Nov 1;356:123014
Life sciences 2024 Nov 1;356:123014
Oral edaravone ameliorates behavioral deficits and pathologies in a valproic acid-induced rat model of autism spectrum disorder.
Lu XY, Li MQ, Li YT, Yao JY, Zhang LX, Zeng ZH, Yu-Liu, Chen ZR, Li CQ, Zhou XF, Li F
Neuropharmacology 2024 Nov 1;258:110089
Neuropharmacology 2024 Nov 1;258:110089
Gaudichaudione H ameliorates liver fibrosis and inflammation by targeting NRF2 signaling pathway.
Shi M, Guo Y, Xu J, Yan L, Li X, Liu R, Feng Y, Zhang Y, Zhao Y, Zhang C, Du K, Li M, Zhang Y, Zhang J, Li Z, Ren D, Liu P
Free radical biology & medicine 2024 Nov 1;224:770-784
Free radical biology & medicine 2024 Nov 1;224:770-784
Unconjugated bilirubin promotes uric acid restoration by activating hepatic AMPK pathway.
Zhang Y, Chen Y, Chen X, Gao Y, Luo J, Lu S, Li Q, Li P, Bai M, Jiang T, Zhang N, Zhang B, Chen B, Zhou H, Jiang H, Lin N
Free radical biology & medicine 2024 Nov 1;224:644-659
Free radical biology & medicine 2024 Nov 1;224:644-659
Hydrogen sulfide upregulates SIRT1 to inhibit ox-HDL-induced endothelial cell damage and mitochondrial dysfunction.
Zhao Y, Wang Y, Zheng H, Xu Q, Zhou K, Liu H, Xia Y, Wei DH, Jiang M, Tang ZH, Liu LS, Zheng H, Jiang Z
Nitric oxide : biology and chemistry 2024 Nov 1;152:78-89
Nitric oxide : biology and chemistry 2024 Nov 1;152:78-89
Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant Non-Small Cell Lung Cancer.
Araujo HA, Pechuan-Jorge X, Zhou T, Do MT, Hu X, Rojas Alvarez FR, Salvatierra ME, Ibarguen HP, Lee R, Raghulan R, Shah H, Moreno Ayala MA, Chen K, Tovbis Shifrin N, Wu S, Solis Soto LM, Negrao MV, Gibbons DL, Hong DS, Roth JA, Heymach JV, Zhang J, Jiang J, Singh M, Smith JAM, Quintana E, Skoulidis F
Cancer discovery 2024 Nov 1;14(11):2183-2208
Cancer discovery 2024 Nov 1;14(11):2183-2208
An RGD-Conjugated Prodrug Nanoparticle with Blood-Brain-Barrier Penetrability for Neuroprotection Against Cerebral Ischemia-Reperfusion Injury.
Taledaohan A, Tuohan MM, Jia R, Wang K, Chan L, Jia Y, Wang F, Wang Y
Antioxidants (Basel, Switzerland) 2024 Nov 1;13(11)
Antioxidants (Basel, Switzerland) 2024 Nov 1;13(11)
Identification of ROS and KEAP1-related genes and verified targets of α-hederin induce cell death for CRC.
Wang G, Zhu ZM, Wang K
Drug development research 2024 May;85(3):e22200
Drug development research 2024 May;85(3):e22200
Sodium butyrate alleviates experimental autoimmune prostatitis by inhibiting oxidative stress and NLRP3 inflammasome activation via the Nrf2/HO-1 pathway.
Hua X, Zhang J, Chen J, Feng R, Zhang L, Chen X, Jiang Q, Yang C, Liang C
The Prostate 2024 May;84(7):666-681
The Prostate 2024 May;84(7):666-681
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Zhao L, Zhang Z, Li P, Gao Y, Shi Y
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species.
Yamashita SI, Sugiura Y, Matsuoka Y, Maeda R, Inoue K, Furukawa K, Fukuda T, Chan DC, Kanki T
Cell death and differentiation 2024 May;31(5):651-661
Cell death and differentiation 2024 May;31(5):651-661
Resveratrol ameliorates ulcerative colitis by upregulating Nrf2/HO‑1 pathway activity: Integrating animal experiments and network pharmacology.
Yu X, Li X, Xu Y, Li Y, Zhou Y, Zhang J, Guo L
Molecular medicine reports 2024 May;29(5)
Molecular medicine reports 2024 May;29(5)
Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress.
Lan Y, Tian F, Tang H, Pu P, He Q, Duan L
Molecular medicine reports 2024 May;29(5)
Molecular medicine reports 2024 May;29(5)
Lotus Leaf Extract Alleviates Lipopolysaccharide-Induced Intestinal Injury in Mice by Regulating Oxidative Stress and Inflammation.
Su Y, Huang J, Shi P, Li P, Huang P, Zeng J
Journal of medicinal food 2024 May;27(5):428-436
Journal of medicinal food 2024 May;27(5):428-436
Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling.
Sheng W, Li B, Sun T, Zhu C, Li Y, Xu W
Experimental and therapeutic medicine 2024 May;27(5):232
Experimental and therapeutic medicine 2024 May;27(5):232
Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing.
Chai G, Wang N, Xu M, Ma L, Liu X, Ding Q, Zhang S, Li A, Xia G, Zhao Y, Liu W, Liang D, Ding C
International journal of biological macromolecules 2024 May;268(Pt 2):131670
International journal of biological macromolecules 2024 May;268(Pt 2):131670
Indole-3-carbinol ameliorates ovarian damage in female old mice through Nrf2/HO-1 pathway activation.
Hu H, Li F, Zhu F, Li J, Wang S, He Z, Chen J, Cheng L, Zhong F
Biochemical pharmacology 2024 May;223:116193
Biochemical pharmacology 2024 May;223:116193
Resveratrol alleviates inorganic arsenic-induced ferroptosis in chicken brain via activation of the Nrf2 signaling pathway.
Pang S, Han B, Wu P, Yang X, Liu Y, Li J, Lv Z, Zhang Z
Pesticide biochemistry and physiology 2024 May;201:105885
Pesticide biochemistry and physiology 2024 May;201:105885
Mastoparan M promotes functional recovery in stroke mice by activating autophagy and inhibiting ferroptosis.
Wang Q, Liu C, Chen M, Zhao J, Wang D, Gao P, Zhang C, Zhao H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116560
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116560
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Chen X, Wang B, Zhou Y, Wu X, Du A, Al Mamun A, Xu Y, Wang S, Jiang C, Xie L, Zhou K, Hu S, Xiao J
Advanced healthcare materials 2024 May;13(12):e2303462
Advanced healthcare materials 2024 May;13(12):e2303462
Aucubin alleviates doxorubicin-induced cardiotoxicity through crosstalk between NRF2 and HIPK2 mediating autophagy and apoptosis.
Li W, Cao J, Zhang Y, Ling G, Tan N, Wei Y, Zhang Y, Wang X, Qian W, Jiang J, Zhang J, Wang W, Wang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155473
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155473
Protective effects of sodium humate and its zinc and selenium chelate on the oxidative stress, inflammatory, and intestinal barrier damage of Salmonella Typhimurium-challenged broiler chickens.
Fan Y, Zhou W, Li G, Liu X, Zhong P, Liu K, Liu Y, Wang D
Poultry science 2024 May;103(5):103541
Poultry science 2024 May;103(5):103541
A Japanese herbal medicine (kampo), hochuekkito (TJ-41), has anti-inflammatory effects on the chronic obstructive pulmonary disease mouse model.
Yuki M, Ishimori T, Kono S, Nagoshi S, Saito M, Isago H, Tamiya H, Fukuda K, Miyashita N, Ishii T, Matsuzaki H, Hiraishi Y, Saito A, Jo T, Nagase T, Mitani A
Scientific reports 2024 May 6;14(1):10361
Scientific reports 2024 May 6;14(1):10361
Molecular, biological characterization and drug sensitivity of chidamide-resistant MCF7 cells.
Dai L, Zhang C, Gao W, Pan J, Huang S, Zhang Y, Cheng Y, Wang Y, Tao J, Wang H, Feng Z, Su C, Zhang Y
Translational cancer research 2024 May 31;13(5):2372-2386
Translational cancer research 2024 May 31;13(5):2372-2386
LC-MS-based rheumatoid arthritis serum metabolomics reveals the role of deoxyinosine in attenuating collagen-induced arthritis in mice.
Xu D, Tang L, Wang Y, Pan J, Su C
Heliyon 2024 May 30;10(10):e30903
Heliyon 2024 May 30;10(10):e30903
Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis.
Li H, Cao Z, Liu C, Wang Y, Wang L, Tang Y, Yao P
Journal of agricultural and food chemistry 2024 May 29;72(21):12156-12170
Journal of agricultural and food chemistry 2024 May 29;72(21):12156-12170
ABI3BP promotes renal aging through Klotho-mediated ferroptosis.
Ji R, Wei L, Zan Y, Li X, Ma S, Ma L, He X, Wang L, Ding Y
Journal of translational medicine 2024 May 29;22(1):514
Journal of translational medicine 2024 May 29;22(1):514
Disease-modifying potential of diphenyl diselenide in an experimental osteoarthritis model.
Qiao L, Li Z, Shi P
Biochemical and biophysical research communications 2024 May 28;710:149885
Biochemical and biophysical research communications 2024 May 28;710:149885
Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis.
Liu X, Liu R, Wang Y
Biochemical and biophysical research communications 2024 May 28;710:149880
Biochemical and biophysical research communications 2024 May 28;710:149880
Mapping the tumor stress network reveals dynamic shifts in the stromal oxidative stress response.
Lior C, Barki D, Halperin C, Iacobuzio-Donahue CA, Kelsen D, Shouval RS
Cell reports 2024 May 28;43(5):114236
Cell reports 2024 May 28;43(5):114236
FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control.
Ge Y, Wu X, Cai Y, Hu Q, Wang J, Zhang S, Zhao B, Cui W, Wu Y, Wang Q, Feng T, Liu H, Qu Y, Ge S
Cell death & disease 2024 May 27;15(5):364
Cell death & disease 2024 May 27;15(5):364
Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.
Li Y, Xiao Y, Shang Y, Xu C, Han C, Hu D, Han J, Wang H
Cell biology and toxicology 2024 May 25;40(1):39
Cell biology and toxicology 2024 May 25;40(1):39
Phosphatidylserine Counteracts the High Stocking Density-Induced Stress Response, Redox Imbalance and Immunosuppression in Fish Megalobrama ambylsephala.
Jiang Y, Liu Z, Zhang L, Liu W, Li H, Li X
Antioxidants (Basel, Switzerland) 2024 May 25;13(6)
Antioxidants (Basel, Switzerland) 2024 May 25;13(6)
Chondrocyte-targeted exosome-mediated delivery of Nrf2 alleviates cartilaginous endplate degeneration by modulating mitochondrial fission.
Lin Z, Xu G, Lu X, Liu S, Zou F, Ma X, Jiang J, Wang H, Song J
Journal of nanobiotechnology 2024 May 24;22(1):281
Journal of nanobiotechnology 2024 May 24;22(1):281
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury.
Wang Y, Fu X, Zeng L, Hu Y, Gao R, Xian S, Liao S, Huang J, Yang Y, Liu J, Jin H, Klaunig J, Lu Y, Zhou S
Communications biology 2024 May 23;7(1):621
Communications biology 2024 May 23;7(1):621
A recombinant plasmid encoding human hepatocyte growth factor promotes healing of combined radiation-trauma skin injury involved in regulating Nrf2 pathway in mice.
Li D, Lu Y, Xiao F, Cheng X, Hu C, Zhu X, Wang X, Duan H, Du L, Zhang Q
Journal of radiation research 2024 May 23;65(3):279-290
Journal of radiation research 2024 May 23;65(3):279-290
Lizhong decoction ameliorates ulcerative colitis by inhibiting ferroptosis of enterocytes via the Nrf2/SLC7A11/GPX4 pathway.
Li W, Wang Y, Zhang Y, Fan Y, Liu J, Zhu K, Jiang S, Duan J
Journal of ethnopharmacology 2024 May 23;326:117966
Journal of ethnopharmacology 2024 May 23;326:117966
Local Application of Tanshinone IIA protects mesenchymal stem cells from apoptosis and promotes fracture healing in ovariectomized mice.
Cheng S, Hu X, Sun K, Huang Z, Zhao Y, Sun Y, Zeng B, Wang J, Zhao D, Lu S, Shi Q, Wang Y, Zhang W, Liu X, Shu B
Journal of orthopaedic surgery and research 2024 May 23;19(1):309
Journal of orthopaedic surgery and research 2024 May 23;19(1):309
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway.
Lu P, Li S, Zhang C, Jiang X, Xiang J, Xu H, Dong J, Wang K, Shi Y
European journal of histochemistry : EJH 2024 May 22;68(2)
European journal of histochemistry : EJH 2024 May 22;68(2)
Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways.
Jiang XX, Zhang R, Wang HS
Aging 2024 May 21;16(10):8630-8644
Aging 2024 May 21;16(10):8630-8644
PPARγ Antagonists Exhibit Antitumor Effects by Regulating Ferroptosis and Disulfidptosis.
Zhang S, Wang Y, Gu J, Yang Y, Liang J, Wang Y, Ji N, Liu M, Zhang Y, Sun S, Chen Q, Li J
Biomolecules 2024 May 18;14(5)
Biomolecules 2024 May 18;14(5)
The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis.
Wu A, Zhong C, Song X, Yuan W, Tang M, Shu T, Huang H, Yang P, Liu Q
iScience 2024 May 17;27(5):109510
iScience 2024 May 17;27(5):109510
Protecting effects of 4-octyl itaconate on neonatal hypoxic-ischemic encephalopathy via Nrf2 pathway in astrocytes.
Yang Y, Li Y, Yang W, Yang X, Luo M, Qin L, Zhu J
Journal of neuroinflammation 2024 May 17;21(1):132
Journal of neuroinflammation 2024 May 17;21(1):132
Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways.
Wang C, Xiong ZM, Cong YQ, Li ZY, Xie Y, Wang YX, Zhou HM, Yang YF, Liu JJ, Wu HZ
Scientific reports 2024 May 16;14(1):11240
Scientific reports 2024 May 16;14(1):11240
Involvement of ferroptosis in eribulin-induced cytotoxicity in ovarian clear cell carcinoma.
Azumi M, Kusama K, Yoshie M, Nakano S, Tsuru A, Kato T, Tamura K
European journal of pharmacology 2024 May 15;971:176544
European journal of pharmacology 2024 May 15;971:176544
FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway.
Huang WT, Chen XJ, Lin YK, Shi JF, Li H, Wu HD, Jiang RL, Chen S, Wang X, Tan XX, Chen KY, Wang P
European journal of pharmacology 2024 May 15;971:176521
European journal of pharmacology 2024 May 15;971:176521
Effects of KEAP1 Silencing on NRF2 and NOTCH Pathways in SCLC Cell Lines.
Fabrizio FP, Sparaneo A, Gorgoglione G, Battista P, Centra F, Delli Muti F, Trombetta D, Centonza A, Graziano P, Rossi A, Fazio VM, Muscarella LA
Cancers 2024 May 15;16(10)
Cancers 2024 May 15;16(10)
Effects of Pemafibrate on Reducing Oxidative Stress and Augmenting Angiogenesis in Ischemic Limb Tissue.
Anegawa T, Sasaki KI, Ishizaki Y, Negoto S, Oryoji A, Nakamura E, Otsuka H, Hiromatsu S, Fukumoto Y, Tayama E
The Kurume medical journal 2024 May 14;69(3.4):167-174
The Kurume medical journal 2024 May 14;69(3.4):167-174
CDDO, an Anti-Inflammatory and Antioxidant Compound, Attenuates Vasospasm and Neuronal Cell Apoptosis in Rats Subjected to Experimental Subarachnoid Hemorrhage.
Winardi W, Lo YP, Tsai HP, Huang YH, Tseng TT, Chung CL
Current issues in molecular biology 2024 May 13;46(5):4688-4700
Current issues in molecular biology 2024 May 13;46(5):4688-4700
Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.
Jia L, Gong Y, Jiang X, Fan X, Ji Z, Ma T, Li R, Liu F
Journal of ethnopharmacology 2024 May 10;325:117887
Journal of ethnopharmacology 2024 May 10;325:117887
Cytotoxic withanolides from the stems and leaves of Physalis ixocarpa.
Xiang K, Liu Y, Zhu R, Xu Y, Sun D, Yang Y, Yan Y, Yang B, Li H, Chen L
Food chemistry 2024 May 1;439:138136
Food chemistry 2024 May 1;439:138136
Edaravone dexborneol protects against cerebral ischemia/reperfusion-induced blood-brain barrier damage by inhibiting ferroptosis via activation of nrf-2/HO-1/GPX4 signaling.
Xiao P, Huang H, Zhao H, Liu R, Sun Z, Liu Y, Chen N, Zhang Z
Free radical biology & medicine 2024 May 1;217:116-125
Free radical biology & medicine 2024 May 1;217:116-125
Involvement of the Keap1-Nrf2-ARE pathway in the antioxidant activity of sinomenine.
Guan T, Li N, Xu X, Xiong D, Wang B, Xiao L, Yang W, Chu G, Yusuf A, Zhang J, Yue W
Archives of biochemistry and biophysics 2024 Mar;753:109928
Archives of biochemistry and biophysics 2024 Mar;753:109928
Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway.
Man S, Bi J, Liu F, Xie W, Ma L
Molecular nutrition & food research 2024 Mar;68(6):e2300706
Molecular nutrition & food research 2024 Mar;68(6):e2300706
RTA-408 Regulates p-NF-κB/TSLP/STAT5 Signaling to Ameliorate Nociceptive Hypersensitivity in Chronic Constriction Injury Rats.
Lu YY, Tsai HP, Tsai TH, Miao HC, Zhang ZH, Wu CH
Molecular neurobiology 2024 Mar;61(3):1714-1725
Molecular neurobiology 2024 Mar;61(3):1714-1725
Quercetin-3-O-β-D-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation.
Mao H, Feng Y, Feng J, Yusufu Y, Sun M, Yang L, Jiang Q
Journal of orthopaedic translation 2024 Mar;45:236-246
Journal of orthopaedic translation 2024 Mar;45:236-246
Protective Effects of Hinokitiol on Neuronal Ferroptosis by Activating the Keap1/Nrf2/HO-1 Pathway in Traumatic Brain Injury.
Tang H, He K, Zhao K, Zheng C, Wu W, Jin W, Yang L, Xie B
Journal of neurotrauma 2024 Mar;41(5-6):734-750
Journal of neurotrauma 2024 Mar;41(5-6):734-750
Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy.
Takahashi K, Kurokawa K, Hong L, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M
Experimental neurology 2024 Mar;373:114671
Experimental neurology 2024 Mar;373:114671
Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway.
Jiang Z, Yang H, Ni W, Gao X, Pei X, Jiang H, Su J, Weng R, Fei Y, Gao Y, Gu Y
CNS neuroscience & therapeutics 2024 Mar;30(3):e14646
CNS neuroscience & therapeutics 2024 Mar;30(3):e14646
Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.
Che J, Wang H, Dong J, Wu Y, Zhang H, Fu L, Zhang J
CNS neuroscience & therapeutics 2024 Mar;30(3):e14454
CNS neuroscience & therapeutics 2024 Mar;30(3):e14454
Electroacupuncture Attenuates Ventilator-Induced Lung Injury by Modulating the Nrf2/HO-1 Pathway.
Luo J, Yan R, Ding L, Ning J, Chen M, Guo Y, Liu J, Chen Z, Zhou R
The Journal of surgical research 2024 Mar;295:811-819
The Journal of surgical research 2024 Mar;295:811-819
Rhizoma Paridis saponins attenuate Gram-negative bacteria-induced inflammatory acne by binding to KEAP1 and modulating Nrf2 and MAPK pathways.
Yang Y, Wang C, Wang J, Yang L, Lv Z, An Q, Wang Y, Shao X, Wang F, Huo T, Liu J, Luo H, Quan Q
Journal of cellular and molecular medicine 2024 Mar;28(6):e18146
Journal of cellular and molecular medicine 2024 Mar;28(6):e18146
Intermittent hypoxia induces hepatic senescence through promoting oxidative stress in a mouse model.
Li Y, Chen Y, Kuang J, Deng S, Wang Y
Sleep & breathing = Schlaf & Atmung 2024 Mar;28(1):183-191
Sleep & breathing = Schlaf & Atmung 2024 Mar;28(1):183-191
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei.
Miao L, Wang ST, Wei QH, Ma RF, Zhang H
Phytochemistry 2024 Mar;219:113984
Phytochemistry 2024 Mar;219:113984
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Jia C, Wu Y, Gao F, Liu W, Li N, Chen Y, Sun L, Wang S, Yu C, Bao Y, Song Z
Free radical biology & medicine 2024 Mar;214:2-18
Free radical biology & medicine 2024 Mar;214:2-18
β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer.
Wang H, Liu J, Zhang Z, Peng J, Wang Z, Yang L, Wang X, Hu S, Hong L
Free radical biology & medicine 2024 Mar;214:137-157
Free radical biology & medicine 2024 Mar;214:137-157
Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury.
Shi W, Wang J, Li Z, Xu S, Wang J, Zhang L, Yang H
Free radical biology & medicine 2024 Mar;213:343-358
Free radical biology & medicine 2024 Mar;213:343-358
ADSC-Exos enhance functional recovery after spinal cord injury by inhibiting ferroptosis and promoting the survival and function of endothelial cells through the NRF2/SLC7A11/GPX4 pathway.
Wu S, Chen Z, Wu Y, Shi Q, Yang E, Zhang B, Qian Y, Lian X, Xu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116225
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116225
Nrf-2/ROS/NF-κB pathway is modulated by cynarin in human mesenchymal stem cells in vitro from ankylosing spondylitis.
Song C, Wang K, Qian B, Lu J, Qiao M, Qiu Y, Wang B, Yu Y
Clinical and translational science 2024 Mar;17(3):e13748
Clinical and translational science 2024 Mar;17(3):e13748
Retinoic acid alleviates rotavirus-induced intestinal damage by regulating redox homeostasis and autophagic flux in piglets.
Lai X, Wu A, Yu B, Yan H, Luo J, Zheng P, Yu J, Chen D
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Mar;16:409-421
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Mar;16:409-421
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy.
Linghu KG, Zhang T, Zhang GT, Lv P, Zhang WJ, Zhao GD, Xiong SH, Ma QS, Zhao MM, Chen M, Hu YJ, Zhang CS, Yu H
Journal of pharmaceutical analysis 2024 Mar;14(3):401-415
Journal of pharmaceutical analysis 2024 Mar;14(3):401-415
LuQi formula attenuates Cardiomyocyte ferroptosis via activating Nrf2/GPX4 signaling axis in heart failure.
Cheng P, Wang X, Liu Q, Yang T, Dai E, Sha W, Qu H, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155357
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155357
Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
Xu CY, Xu C, Xu YN, Du SQ, Dai ZH, Jin SQ, Zheng G, Xie CL, Fang WL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155342
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155342
X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity.
Hong Y, Zhou X, Li Q, Chen J, Wei Y, Long C, Shen L, Zheng X, Li D, Wang X, Yu C, Wu S, Wei G
Genes & diseases 2024 Mar;11(2):935-951
Genes & diseases 2024 Mar;11(2):935-951
Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis.
Jiang Z, Qi G, He X, Yu Y, Cao Y, Zhang C, Zou W, Yuan H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(12):e2307388
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(12):e2307388
VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy.
Wang H, Yu X, Liu D, Qiao Y, Huo J, Pan S, Zhou L, Wang R, Feng Q, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2305563
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2305563
Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice.
Wang B, Zhu S, Guo M, Ma RD, Tang YL, Nie YX, Gu HF
Molecular medicine (Cambridge, Mass.) 2024 Mar 7;30(1):35
Molecular medicine (Cambridge, Mass.) 2024 Mar 7;30(1):35
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
Xu J, Ruan Z, Guo Z, Hou L, Wang G, Zheng Z, Zhang X, Liu H, Sun K, Guo F
Bone & joint research 2024 Mar 7;13(3):110-123
Bone & joint research 2024 Mar 7;13(3):110-123
Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats.
Chen H, Sun H, Hua W, Chang H, Chen W, Ma S
European journal of pharmacology 2024 Mar 5;966:176344
European journal of pharmacology 2024 Mar 5;966:176344
Methylmercury Induces Apoptosis in Mouse C17.2 Neural Stem Cells through the Induction of OSGIN1 Expression by NRF2.
Yamashita N, Uchiyama M, Yamagata R, Hwang GW
International journal of molecular sciences 2024 Mar 30;25(7)
International journal of molecular sciences 2024 Mar 30;25(7)
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx.
Xiang Z, Zhang P, Jia C, Xu R, Cao D, Xu Z, Lu T, Liu J, Wang X, Qiu C, Fu W, Li W, Cheng L, Yang Q, Feng S, Wang L, Zhao Y, Liu X
Bone research 2024 Mar 29;12(1):20
Bone research 2024 Mar 29;12(1):20
Mechanism of Porphyra Yezoensis Polysaccharides in Inhibiting Hyperoxalate-Induced Renal Injury and Crystal Deposition.
Deng JW, Li CY, Huang YP, Liu WF, Zhang Q, Long J, Wu WQ, Huang LH, Zeng GH, Sun XY
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6372-6388
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6372-6388
Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway.
Liu H, Lu Q
International journal of molecular sciences 2024 Mar 27;25(7)
International journal of molecular sciences 2024 Mar 27;25(7)
A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver.
Materozzi M, Resnati M, Facchi C, Trudu M, Orfanelli U, Perini T, Gennari L, Milan E, Cenci S
Scientific reports 2024 Mar 27;14(1):7290
Scientific reports 2024 Mar 27;14(1):7290
Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2.
Chen X, Zhou Q, Chen H, Bai J, An R, Zhang K, Zhang X, An H, Zhang J, Wang Y, Li M
Antioxidants (Basel, Switzerland) 2024 Mar 27;13(4)
Antioxidants (Basel, Switzerland) 2024 Mar 27;13(4)
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.
Deng B, Liu F, Chen N, Li X, Lei J, Chen N, Wu J, Wang X, Lu J, Fang M, Chen A, Zhang Z, He B, Yan M, Zhang Y, Wang Z, Liu Q
Cell death & disease 2024 Mar 23;15(3):233
Cell death & disease 2024 Mar 23;15(3):233
Bi(2)S(3)/Ti(3)C(2)-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors.
Jiang H, Sun J, Liu F, Zhao Y, Chen X, Dai C, Wen Z
Journal of nanobiotechnology 2024 Mar 20;22(1):123
Journal of nanobiotechnology 2024 Mar 20;22(1):123
Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway.
Xin X, Liu J, Liu X, Xin Y, Hou Y, Xiang X, Deng Y, Yang B, Yu W
ACS nano 2024 Mar 19;18(11):8307-8324
ACS nano 2024 Mar 19;18(11):8307-8324
Anti-inflammatory and anti-oxidative electrospun nanofiber membrane promotes diabetic wound healing via macrophage modulation.
He J, Zhou S, Wang J, Sun B, Ni D, Wu J, Peng X
Journal of nanobiotechnology 2024 Mar 16;22(1):116
Journal of nanobiotechnology 2024 Mar 16;22(1):116
Pentoxifylline protects against cerebral ischaemia-reperfusion injury through ferroptosis regulation via the Nrf2/SLC7A11/GPX4 signalling pathway.
Li P, Chen JM, Ge SH, Sun ML, Lu JD, Liu F, Wang LL, Zhang X, Wang XP
European journal of pharmacology 2024 Mar 15;967:176402
European journal of pharmacology 2024 Mar 15;967:176402
Identifying key antioxidative stress factors regulating Nrf2 in the genioglossus with human umbilical cord mesenchymal stem-cell therapy.
Guo H, Liu Y, Yu X, Tian N, Liu Y, Yu D
Scientific reports 2024 Mar 10;14(1):5838
Scientific reports 2024 Mar 10;14(1):5838
SAP130 released by ferroptosis tubular epithelial cells promotes macrophage polarization via Mincle signaling in sepsis acute kidney injury.
Zhang J, Jiang J, Wang B, Wang Y, Qian Y, Suo J, Li Y, Peng Z
International immunopharmacology 2024 Mar 10;129:111564
International immunopharmacology 2024 Mar 10;129:111564
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis.
Shen J, Hao C, Yuan S, Chen W, Tong T, Chen Y, Shahzad Aslam M, Yan S, Li J, Zeng J, Liu S, Chen Y, Jiang Y, Li P, Meng X
Brain research 2024 Mar 1;1826:148715
Brain research 2024 Mar 1;1826:148715
Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis.
Ye Y, Xu L, Zhang L, Zhao P, Cai W, Fu G, Wang T, Tao Z, Shi W, Gu W, Hu J, Yuan G, Wei Y, Xu K, Bao Z, Chao H, Liu N, Zhao L, Tu Y, Ji J
Redox biology 2024 Jun;72:103137
Redox biology 2024 Jun;72:103137
4-Octyl Itaconate Inhibits Proinflammatory Cytokine Production in Behcet's Uveitis and Experimental Autoimmune Uveitis.
Wang Q, Ye X, Tan S, Jiang Q, Su G, Pan S, Li H, Cao Q, Yang P
Inflammation 2024 Jun;47(3):909-920
Inflammation 2024 Jun;47(3):909-920
PHPB ameliorates memory deficits and reduces oxidative injury in Alzheimer's disease mouse model by activating Nrf2 signaling pathway.
Shang NY, Huang LJ, Lan JQ, Kang YY, Tang JS, Wang HY, Li XN, Sun Z, Chen QY, Liu MY, Wen ZP, Feng XH, Wu L, Peng Y
Acta pharmacologica Sinica 2024 Jun;45(6):1142-1159
Acta pharmacologica Sinica 2024 Jun;45(6):1142-1159
Bicyclol Alleviates Streptozotocin-induced Diabetic Cardiomyopathy By Inhibiting Chronic Inflammation And Oxidative Stress.
Zhang L, Hu C, Jin B, Bai B, Liao J, Jin L, Wang M, Zhu W, Wu X, Zheng L, Xu X, Jiang Y, Wang Y, He Y
Cardiovascular drugs and therapy 2024 Jun;38(3):555-568
Cardiovascular drugs and therapy 2024 Jun;38(3):555-568
An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy.
Wang H, Liu X, Yan X, Du Y, Pu F, Ren J, Qu X
Biomaterials 2024 Jun;307:122523
Biomaterials 2024 Jun;307:122523
An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness.
Peng H, Feng K, Jia W, Li Y, Lv Q, Zhang Y
Apoptosis : an international journal on programmed cell death 2024 Jun;29(5-6):898-919
Apoptosis : an international journal on programmed cell death 2024 Jun;29(5-6):898-919
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Liu C, Sun Y, Li D, Wang F, Wang H, An S, Sun S
Materials today. Bio 2024 Jun;26:101034
Materials today. Bio 2024 Jun;26:101034
Total flavonoids of Broussonetia papyrifera alleviate non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signaling pathways.
Wang Q, Wei Y, Wang Y, Yu Z, Qin H, Zhao L, Cheng J, Shen B, Jin M, Feng H
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Jun;1869(5):159497
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Jun;1869(5):159497
Dihydromyricetin regulates KEAP1-Nrf2 pathways to enhance the survival of ischemic flap.
Tao X, Pan X, Zhao G, Xue M, Rui Y
Food science & nutrition 2024 Jun;12(6):3893-3909
Food science & nutrition 2024 Jun;12(6):3893-3909
Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.
Hu Y, Hao R, Li D, Lu Y, Yu G
BMC complementary medicine and therapies 2024 Jun 8;24(1):222
BMC complementary medicine and therapies 2024 Jun 8;24(1):222
Homotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases.
Liao W, Li Y, Liu J, Mou Y, Zhao M, Liu J, Zhang T, Sun Q, Tang J, Wang Z
Cell communication and signaling : CCS 2024 Jun 7;22(1):315
Cell communication and signaling : CCS 2024 Jun 7;22(1):315
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
Duan WL, Ma YP, Wang XJ, Ma CS, Han B, Sheng ZM, Dong H, Zhang LY, Li PA, Zhang BG, He MT
European journal of pharmacology 2024 Jun 5;972:176553
European journal of pharmacology 2024 Jun 5;972:176553
ROS Induced by Aphrocallistes vastus Lectin Enhance Oncolytic Vaccinia Virus Replication and Induce Apoptosis in Hepatocellular Carcinoma Cells.
Zhang Y, Zhu Y, Jiang G, Chen K, Zhang G, Chen K, Ye T, Zhou Y, Li G
Marine drugs 2024 Jun 30;22(7)
Marine drugs 2024 Jun 30;22(7)
Isorhamnetin alleviates ferroptosis-mediated colitis by activating the NRF2/HO-1 pathway and chelating iron.
Ru Y, Luo Y, Liu D, Huang Q, Zhou X, Linghu M, Luo X, Lv Z, Wu Y, Zhang H, Huang Y
International immunopharmacology 2024 Jun 30;135:112318
International immunopharmacology 2024 Jun 30;135:112318
Nicotine promotes Staphylococcus aureus-induced osteomyelitis by activating the Nrf2/Slc7a11 signaling axis.
Zhou X, Ma S, Xu Y, Sun C, Liao J, Song M, Li G, Yuchen L, Chen P, Hu Y, Wang Y, Yu B
International immunopharmacology 2024 Jun 30;135:112223
International immunopharmacology 2024 Jun 30;135:112223
Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.
Chen J, Hu J, Guo X, Yang Y, Qin D, Tang X, Huang Z, Wang F, Hu D, Peng D, Yu B
Cell death & disease 2024 Jun 3;15(6):389
Cell death & disease 2024 Jun 3;15(6):389
PPIA dictates NRF2 stability to promote lung cancer progression.
Lu W, Cui J, Wang W, Hu Q, Xue Y, Liu X, Gong T, Lu Y, Ma H, Yang X, Feng B, Wang Q, Zhang N, Xu Y, Liu M, Nussinov R, Cheng F, Ji H, Huang J
Nature communications 2024 Jun 3;15(1):4703
Nature communications 2024 Jun 3;15(1):4703
Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway.
Yu Y, Liang J, Yuan Z, Wang A, Liu X, Chen Y, Zhang M, Gao Y, Zhang H, Liu Y
Journal of ethnopharmacology 2024 Jun 28;328:118135
Journal of ethnopharmacology 2024 Jun 28;328:118135
Mechanistic studies on the alleviation of ANIT-induced cholestatic liver injury by Polygala fallax Hemsl. polysaccharides.
Guan G, Cao H, Tang Z, Zhang K, Zhong M, Lv R, Wan W, Guo F, Wang Y, Gao Y
Journal of ethnopharmacology 2024 Jun 28;328:118108
Journal of ethnopharmacology 2024 Jun 28;328:118108
Bradykinin induces acute kidney injury after hypothermic circulatory arrest through the repression of the Nrf2-xCT pathway.
Li J, Wang M, Wang M, Sang H, Wang W, Gong M, Zhang H
iScience 2024 Jun 21;27(6):110075
iScience 2024 Jun 21;27(6):110075
Fucoxanthin alleviates lipopolysaccharide-induced intestinal barrier injury in mice.
Du L, Chen C, Yang YH, Zheng Y, Li H, Wu ZJ, Wu H, Miyashita K, Su GH
Food & function 2024 Jun 17;15(12):6359-6373
Food & function 2024 Jun 17;15(12):6359-6373
Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload.
Wang C, Zhao H, Liu Y, Qu M, Lv S, He G, Liang H, Chen K, Yang L, He Y, Ou C
Ecotoxicology and environmental safety 2024 Jun 15;278:116404
Ecotoxicology and environmental safety 2024 Jun 15;278:116404
Involvement of P2X7R-mediated microglia polarization and neuroinflammation in the response to electroacupuncture on post-stroke memory impairment.
Lin B, Wang M, Chen X, Chai L, Ni J, Huang J
Brain research bulletin 2024 Jun 15;212:110967
Brain research bulletin 2024 Jun 15;212:110967
X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway.
Du MW, Zhu XL, Zhang DX, Chen XZ, Yang LH, Xiao JZ, Fang WJ, Xue XC, Pan WH, Liao WQ, Yang T
World journal of diabetes 2024 Jun 15;15(6):1299-1316
World journal of diabetes 2024 Jun 15;15(6):1299-1316
FGF10 protects against particulate matter-induced lung injury by inhibiting ferroptosis via Nrf2-dependent signaling.
Qian Y, Shi Q, Zhou W, He B, Xu H, Liu B, Miao W, Bellusci S, Chen C, Dong N
International immunopharmacology 2024 Jun 15;134:112165
International immunopharmacology 2024 Jun 15;134:112165
Electrical Pulse Stimulation Protects C2C12 Myotubes against Hydrogen Peroxide-Induced Cytotoxicity via Nrf2/Antioxidant Pathway.
Pribil Pardun S, Bhat A, Anderson CP, Allen MF, Bruening W, Jacob J, Pendyala VV, Yu L, Bruett T, Zimmerman MC, Park SY, Zucker IH, Gao L
Antioxidants (Basel, Switzerland) 2024 Jun 12;13(6)
Antioxidants (Basel, Switzerland) 2024 Jun 12;13(6)
Alantolactone attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease.
Wang J, Jiang Y, Jin L, Qian C, Zuo W, Lin J, Xie L, Jin B, Zhao Y, Huang L, Wang Y
Nutrition & diabetes 2024 Jun 10;14(1):41
Nutrition & diabetes 2024 Jun 10;14(1):41
N -N-Butyl Haloperidol Iodide Mitigates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1-Nrf2 Signaling Loop.
Lu B, Feng Z, Wang Y, Liao J, Wang B, Gao F, Zheng F, Shi G, Zhang Y
Journal of cardiovascular pharmacology 2024 Jun 1;83(6):602-611
Journal of cardiovascular pharmacology 2024 Jun 1;83(6):602-611
Docosahexaenoic Acid Coordinating with Sodium Selenite Promotes Paraptosis in Colorectal Cancer Cells by Disrupting the Redox Homeostasis and Activating the MAPK Pathway.
Zhao S, Meng Y, Cai W, Luo Q, Gao H, Shen Q, Shi D
Nutrients 2024 Jun 1;16(11)
Nutrients 2024 Jun 1;16(11)
Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway.
Zhao X, Li M, Lu Y, Wang M, Xiao J, Xie Q, He X, Shuai S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jul;73(7):1173-1184
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jul;73(7):1173-1184
DACH1 Attenuates Airway Inflammation in Chronic Obstructive Pulmonary Disease by Activating NRF2 Signaling.
Huang Q, Gu Y, Wu J, Zhan Y, Deng Z, Chen S, Peng M, Yang R, Chen J, Xie J
American journal of respiratory cell and molecular biology 2024 Jul;71(1):121-132
American journal of respiratory cell and molecular biology 2024 Jul;71(1):121-132
Conditional Knockout of IL-1R1 in Endothelial Cells Attenuates Seizures and Neurodegeneration via Inhibiting Neuroinflammation Mediated by Nrf2/HO-1/NLRP3 Signaling in Status Epilepticus Model.
Wu L, Zhu Y, Qin Y, Yuan H, Zhang L, Lu T, Chen Q, Hu A
Molecular neurobiology 2024 Jul;61(7):4289-4303
Molecular neurobiology 2024 Jul;61(7):4289-4303
Selenium nanoparticles decorated with polysaccharides from Sargassum fusiforme protects against 6-OHDA-induced neurotoxicity in PC12 cells and rat model of Parkinson's disease.
Zhao H, Song J, Wang T, Fan X
Nanomedicine : nanotechnology, biology, and medicine 2024 Jul;59:102755
Nanomedicine : nanotechnology, biology, and medicine 2024 Jul;59:102755
Protective effect of Cyclo(His-Pro) on peritoneal fibrosis through regulation of HDAC3 expression.
Kim JE, Han D, Kim KH, Seo A, Moon JJ, Jeong JS, Kim JH, Kang E, Bae E, Kim YC, Lee JW, Cha RH, Kim DK, Oh KH, Kim YS, Jung HY, Yang SH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul;38(13):e23819
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul;38(13):e23819
PEDF and 34-mer peptide inhibit cardiac microvascular endothelial cell ferroptosis via Nrf2/HO-1 signalling in myocardial ischemia-reperfusion injury.
Lu P, Qi Y, Li X, Zhang C, Chen Z, Shen Z, Liang J, Zhang H, Yuan Y
Journal of cellular and molecular medicine 2024 Jul;28(14):e18558
Journal of cellular and molecular medicine 2024 Jul;28(14):e18558
Magnolol against enterovirus 71 by targeting Nrf2-SLC7A11-GSH pathway.
Zhao D, Guo X, Lin B, Huang R, Li H, Wang Q, Zeng Y, Shang Y, Wu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116866
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116866
Pinocembrin's protective effect against acute pancreatitis in a rat model: The correlation between TLR4/NF-κB/NLRP3 and miR-34a-5p/SIRT1/Nrf2/HO-1 pathways.
Ali BM, Al-Mokaddem AK, Selim HMRM, Alherz FA, Saleh A, Hamdan AME, Ousman MS, El-Emam SZ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116854
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116854
Chemopreventive effects of atractylenolide-III on mammary tumorigenesis via activation of the Nrf2/ARE pathway through autophagic degradation of Keap1.
Long F, Wang P, Ma Y, Zhang X, Wang T
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116852
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116852
Berberine synergises with ferroptosis inducer sensitizing NSCLC to ferroptosis in p53-dependent SLC7A11-GPX4 pathway.
Liao W, Zhang R, Chen G, Zhu X, Wu W, Chen Z, Jiang C, Lin Z, Ma L, Yu H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116832
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116832
Duodenal-jejunal bypass surgery activates eNOS and enhances antioxidant system by activating AMPK pathway to improve heart oxidative stress in diabetic cardiomyopathy rats.
Yang G, Liu Z, Dong S, Zhao X, Ge Z, Cheng Z, Zhang X, Wang K
Journal of diabetes 2024 Jul;16(7):e13516
Journal of diabetes 2024 Jul;16(7):e13516
EZH2 suppresses ferroptosis in hepatocellular carcinoma and reduces sorafenib sensitivity through epigenetic regulation of TFR2.
Lai Y, Han X, Xie B, Xu Y, Yang Z, Wang D, Li W, Xie Y, Song W, Zhang X, Xia JQ, Zhang P
Cancer science 2024 Jul;115(7):2220-2234
Cancer science 2024 Jul;115(7):2220-2234
PXR Activation Relieves Deoxynivalenol-Induced Liver Oxidative Stress Via Malat1 LncRNA m(6)A Demethylation.
Feng Y, Shen J, Lin Z, Chen Z, Zhou M, Ma X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(25):e2308742
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(25):e2308742
Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway.
Zhou J, Li X, Han Z, Qian Y, Bai L, Han Q, Gao M, Xue Y, Geng D, Yang X, Hao Y
Acta biochimica et biophysica Sinica 2024 Jul 8;56(11):1644-1658
Acta biochimica et biophysica Sinica 2024 Jul 8;56(11):1644-1658
Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model.
Ruan H, Zhu T, Wang T, Guo Y, Liu Y, Zheng J
International journal of molecular sciences 2024 Jul 7;25(13)
International journal of molecular sciences 2024 Jul 7;25(13)
Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1.
Ye S, Hu X, Sun S, Su B, Cai J, Jiang J
European journal of pharmacology 2024 Jul 5;974:176620
European journal of pharmacology 2024 Jul 5;974:176620
Inhibition of insulin degrading enzyme suppresses osteoclast hyperactivity via enhancing Nrf2-dependent antioxidant response in glucocorticoid-induced osteonecrosis of the femoral head.
Yuan T, Wang H, Wang Y, Dong S, Ge J, Li Z, Sun S
Molecular medicine (Cambridge, Mass.) 2024 Jul 31;30(1):111
Molecular medicine (Cambridge, Mass.) 2024 Jul 31;30(1):111
Paeoniflorin Promotes Ovarian Development in Mice by Activating Mitophagy and Preventing Oxidative Stress.
Xi H, Wang Z, Li M, Duan X, Li Y
International journal of molecular sciences 2024 Jul 30;25(15)
International journal of molecular sciences 2024 Jul 30;25(15)
The EGR1/miR-139/NRF2 axis orchestrates radiosensitivity of non-small-cell lung cancer via ferroptosis.
Zhang L, Xu Y, Cheng Z, Zhao J, Wang M, Sun Y, Mi Z, Yuan Z, Wu Z
Cancer letters 2024 Jul 28;595:217000
Cancer letters 2024 Jul 28;595:217000
Icariin alleviates cisplatin-induced premature ovarian failure by inhibiting ferroptosis through activation of the Nrf2/ARE pathway.
Li F, Zhu F, Wang S, Hu H, Zhang D, He Z, Chen J, Li X, Cheng L, Zhong F
Scientific reports 2024 Jul 27;14(1):17318
Scientific reports 2024 Jul 27;14(1):17318
Baicalin promotes the sensitivity of NSCLC to cisplatin by regulating ferritinophagy and macrophage immunity through the KEAP1-NRF2/HO-1 pathway.
Chen Y, Bao S, Wang Z, Fang Z, Tang H
European journal of medical research 2024 Jul 26;29(1):387
European journal of medical research 2024 Jul 26;29(1):387
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress.
Hu M, Hu L, Yang T, Zhou B, Feng X, Fan Z, Shan Z
Antioxidants (Basel, Switzerland) 2024 Jul 26;13(8)
Antioxidants (Basel, Switzerland) 2024 Jul 26;13(8)
Targeting the smooth muscle cell KEAP1-Nrf2-STING axis with pterostilbene attenuates abdominal aortic aneurysm.
Zou J, Zheng Z, Ye W, Jin M, Yang P, Little PJ, Wang J, Liu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155696
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155696
Salvianolic acid B protects against UVB-induced skin aging via activation of NRF2.
Sun JM, Liu YX, Liu YD, Ho CK, Tsai YT, Wen DS, Huang L, Zheng DN, Gao Y, Zhang YF, Yu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155676
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155676
Linoleic Acid Alleviates Lipopolysaccharide Induced Acute Liver Injury via Activation of Nrf2.
Zhang Q, Jiang Y, Qin Y, Liu J, Xie Y, Zhang L, Li K, Wang X, Liu G
Physiological research 2024 Jul 17;73(3):381-391
Physiological research 2024 Jul 17;73(3):381-391
ZIF-8-based Nanoparticles for Inflammation Treatment and Oxidative Stress Reduction in Periodontitis.
Li Y, Xu C, Mao J, Mao L, Li W, Liu Z, Shin A, Wu J, Hou L, Li D, Lin K, Liu J
ACS applied materials & interfaces 2024 Jul 17;16(28):36077-36094
ACS applied materials & interfaces 2024 Jul 17;16(28):36077-36094
Single-cell RNA sequencing reveals that NRF2 regulates vascular smooth muscle cell phenotypic switching in abdominal aortic aneurysm.
Xiao X, Li C, Huang X, Chen G, Huang X, Song F, Zhou Y, Liu X, Zhou X, Meng J, Bellou A, Zhong L, Li X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23707
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23707
Zearalenone modulates the function of goat endometrial cells via the mitochondrial quality control system.
Zhang G, Zeng C, Sun X, Zhang Q, Wang Y, Xia R, Mai Q, Xue G, Huang H, Wang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23701
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23701
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
Li Y, Deng X, Hu Q, Chen Y, Zhang W, Qin X, Wei F, Lu X, Ma X, Zeng J, Efferth T
Journal of ethnopharmacology 2024 Jul 15;329:118107
Journal of ethnopharmacology 2024 Jul 15;329:118107
Novel Inhibitor of Keap1-Nrf2 Protein-Protein Interaction Attenuates Osteoclastogenesis In Vitro and Prevents OVX-Induced Bone Loss In Vivo.
Chen Z, Yao H, Encarnacion AM, Jeong J, Choi Y, Park S, Lee S, Lee T
Antioxidants (Basel, Switzerland) 2024 Jul 15;13(7)
Antioxidants (Basel, Switzerland) 2024 Jul 15;13(7)
Lung decellularized matrix-derived 3D spheroids: Exploring silicosis through the impact of the Nrf2/Bax pathway on myofibroblast dynamics.
Xue W, Wang J, Hou Y, Wu D, Wang H, Jia Q, Jiang Q, Wang Y, Song C, Wang Y, Zhu Z, Tian L
Heliyon 2024 Jul 15;10(13):e33585
Heliyon 2024 Jul 15;10(13):e33585
Bacillus cereus CwpFM induces colonic tissue damage and inflammatory responses through oxidative stress and the NLRP3/NF-κB pathway.
Shan Q, Wang X, Yang H, Zhu Y, Wang J, Yang G
The Science of the total environment 2024 Jul 10;933:173079
The Science of the total environment 2024 Jul 10;933:173079
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
Yang J, Zhang Z, Du X, Wang Y, Meng R, Ge K, Wu C, Liang X, Zhang H, Guo H
Environmental research 2024 Jul 1;252(Pt 4):119113
Environmental research 2024 Jul 1;252(Pt 4):119113
Plasma-activated medium ameliorates the chemoresistance of human lung adenocarcinoma cells mediated via downregulation of claudin-2 expression.
Eguchi H, Yu Y, Yoshino Y, Hara H, Tanaka H, Ikari A
Archives of biochemistry and biophysics 2024 Jan;751:109846
Archives of biochemistry and biophysics 2024 Jan;751:109846
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Chen L, Qi E, Liu X, Cui L, Fan X, Wei T, Hu Y
Toxicology and applied pharmacology 2024 Jan;482:116766
Toxicology and applied pharmacology 2024 Jan;482:116766
Empagliflozin reduces endoplasmic reticulum stress associated TXNIP/NLRP3 activation in tunicamycin-stimulated aortic endothelial cells.
Campeau MA, Leask RL
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jan;397(1):267-279
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jan;397(1):267-279
The cyclin-dependent kinase inhibitor abemaciclib-induced hepatotoxicity: Insight on the molecular mechanisms in HepG2/THP-1 co-culture model.
Boran T, Zengin OS, Seker Z, Gunaydin Akyildiz A, Oztas E, Özhan G
Toxicology letters 2024 Jan;391:1-12
Toxicology letters 2024 Jan;391:1-12
Taxifolin-mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of glucocorticoid-induced osteonecrosis of the femoral head.
Jiang H, Lin C, Cai T, Jiang L, Lou C, Lin S, Wang W, Yan Z, Pan X, Xue X
Phytotherapy research : PTR 2024 Jan;38(1):156-173
Phytotherapy research : PTR 2024 Jan;38(1):156-173
TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling.
Wei X, Zhang T, Ma C, Zhang M, Jin L, Ma X, Zhang Z
Experimental neurology 2024 Jan;371:114599
Experimental neurology 2024 Jan;371:114599
Mitochondria-targeted cerium vanadate nanozyme suppressed hypoxia-ischemia injury in neonatal mice via intranasal administration.
Jiang Z, Wang W, Zhao Y, Li T, Xin D, Gai C, Liu D, Wang Z
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:1074-1088
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:1074-1088
Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling.
Zhang Q, Tian L, Hu Y, Jiang W, Wang X, Chen L, Cheng S, Ying J, Jiang B, Zhang L
Toxicology mechanisms and methods 2024 Jan;34(1):20-31
Toxicology mechanisms and methods 2024 Jan;34(1):20-31
Berberine alleviates contrast-induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway.
Wang W, Yu R, Wu C, Li Q, Chen J, Xiao Y, Chen H, Song J, Ji M, Zuo Z
Journal of cellular and molecular medicine 2024 Jan;28(1):e18016
Journal of cellular and molecular medicine 2024 Jan;28(1):e18016
Chronic restraint stress induces abnormal behaviors in pain sensitivity and cognitive function in mice: the role of Keap1/Nrf2 pathway.
Yang N, Wang Y, Luo X, Zhan G
Stress (Amsterdam, Netherlands) 2024 Jan;27(1):2316050
Stress (Amsterdam, Netherlands) 2024 Jan;27(1):2316050
KAN0438757, a novel PFKFB3 inhibitor, prevent the progression of severe acute pancreatitis via the Nrf2/HO-1 pathway in infiltrated macrophage.
Ergashev A, Shi F, Liu Z, Pan Z, Xie H, Kong L, Wu L, Sun H, Jin Y, Kong H, Geng D, Ibrohimov A, Obeng E, Wang Y, Ma F, Chen G, Zhang T
Free radical biology & medicine 2024 Jan;210:130-145
Free radical biology & medicine 2024 Jan;210:130-145
Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.
Tong T, Hao C, Shen J, Liu S, Yan S, Aslam MS, Chen Y, Chen W, Li J, Li Y, Zeng J, Li M, You Z, Gulizhaerkezi T, Wei S, Zhu A, Meng X
Brain research bulletin 2024 Jan;206:110838
Brain research bulletin 2024 Jan;206:110838
Isoliquiritigenin inhibits apoptosis and ameliorates oxidative stress in rheumatoid arthritis chondrocytes through the Nrf2/HO-1-mediated pathway.
Hung SY, Chen JL, Tu YK, Tsai HY, Lu PH, Jou IM, Mbuyisa L, Lin MW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116006
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116006
Chlorogenic acid attenuates deoxynivalenol-induced apoptosis and pyroptosis in human keratinocytes via activating Nrf2/HO-1 and inhibiting MAPK/NF-κB/NLRP3 pathways.
Chen J, Zhou Z, Wu N, Li J, Xi N, Xu M, Wu F, Fu Q, Yan G, Liu Y, Xu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116003
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116003
Improvement of sea buckthorn (Hippophae rhamnoides L.) flavonoids on the antioxidant and immune performance of Yellow River carp (Cyprinus carpio L.) fed high-carbohydrate diet.
Yan X, Pang P, Qin C, Mi J, Yang L, Yang B, Nie G
Fish & shellfish immunology 2024 Jan;144:109289
Fish & shellfish immunology 2024 Jan;144:109289
EGFR/MAPK signaling pathway acts as a potential therapeutic target for sulforaphane-rescued heart tube malformation induced by various concentrations of PhIP exposure.
Wang G, Zhao R, Zhang X, Zheng Y, Xie F, Jiang Y, Lv G, Long D, Sun C, Bao Y, Qi S, Liu X, Zhang Q, Yang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155270
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155270
Intranasal delivery of macrophage cell membrane cloaked biomimetic drug-nanoparticle system attenuates acute lung injury.
Zhao Y, Shen X, Fan Y, Wei N, Ling Z, Yao Y, Fan S, Liu J, Shao Y, Zhou Z, Jin H
Journal of tissue engineering 2024 Jan-Dec;15:20417314241287487
Journal of tissue engineering 2024 Jan-Dec;15:20417314241287487
Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer.
Liu S, Tao Y, Wu S, Lin J, Fu S, Lu J, Zhang J, Fu B, Zhang E, Xu J, Wang J, Li L, Zhang L, Wang Z
Chinese medicine 2024 Jan 9;19(1):7
Chinese medicine 2024 Jan 9;19(1):7
Near-infrared-responsive GE11-CuS@Gal nanoparticles as an intelligent drug release system for targeting therapy against oral squamous cell carcinoma.
Lan Q, Wang S, Chen Z, Hua J, Hu J, Luo S, Xu Y
International journal of pharmaceutics 2024 Jan 5;649:123667
International journal of pharmaceutics 2024 Jan 5;649:123667
Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells.
Xia Q, Xie J, Zhang J, Zhang L, Zhou Y, Zhu B, Wu Y, Yang Z, Li J
Chemico-biological interactions 2024 Jan 5;387:110819
Chemico-biological interactions 2024 Jan 5;387:110819
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Wang G, Li Z, Lin P, Zhang H, Wang Y, Zhang T, Wang H, Li H, Lin L, Zhao Y, Jia L, Chen Y, Ji H, Zhao W, Fu Z, Zhong Z
International immunopharmacology 2024 Jan 5;126:111183
International immunopharmacology 2024 Jan 5;126:111183
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
Wang R, Zeng J, Chen L, Sun L, Wang Y, Xu J, He X
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
Integrated analysis of metabolomic and transcriptomic profiling reveals the effect of Atractylodes oil on Spleen Yang Deficiency Syndrome in rats.
Zhan X, Xiao Y, Jian Q, Dong Y, Ke C, Zhou Z, Liu Y, Tu J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117205
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117205
Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway.
Xiao Y, Duan C, Gong P, Zhao Q, Wang XH, Geng F, Zeng J, Luo T, Xu Y, Zhao J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117152
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117152
Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14/Keap1/Nrf2 pathway.
Ba L, E M, Wang R, Wu N, Wang R, Liu R, Feng X, Qi H, Sun H, Qiao G
Heliyon 2024 Jan 30;10(2):e24010
Heliyon 2024 Jan 30;10(2):e24010
Treadmill exercise can regulate the redox balance in the livers of APP/PS1 mice and reduce LPS accumulation in their brains through the gut-liver-kupffer cell axis.
Yuan S, Wang Y, Yang J, Tang Y, Wu W, Meng X, Jian Y, Lei Y, Liu Y, Tang C, Zhao Z, Zhao F, Liu W
Aging 2024 Jan 29;16(2):1374-1389
Aging 2024 Jan 29;16(2):1374-1389
Taurine Chloramine-Mediated Nrf2 Activation and HO-1 Induction Confer Protective Effects in Astrocytes.
Seol SI, Kang IS, Lee JS, Lee JK, Kim C
Antioxidants (Basel, Switzerland) 2024 Jan 29;13(2)
Antioxidants (Basel, Switzerland) 2024 Jan 29;13(2)
Antioxidative Sirt1 and the Keap1-Nrf2 Signaling Pathway Impair Inflammation and Positively Regulate Autophagy in Murine Mammary Epithelial Cells or Mammary Glands Infected with Streptococcus uberis.
Khan S, Wang T, Cobo ER, Liang B, Khan MA, Xu M, Qu W, Gao J, Barkema HW, Kastelic JP, Liu G, Han B
Antioxidants (Basel, Switzerland) 2024 Jan 29;13(2)
Antioxidants (Basel, Switzerland) 2024 Jan 29;13(2)
Malvidin promotes PGC-1α/Nrf2 signaling to attenuate the inflammatory response and restore mitochondrial activity in septic acute kidney injury.
Fan H, Sun Y, Zhang X, Xu Y, Ming Y, Zhang L, Zhao P
Chemico-biological interactions 2024 Jan 25;388:110850
Chemico-biological interactions 2024 Jan 25;388:110850
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Wu W, Li G, Dong S, Huihan Chu C, Ma S, Zhang Z, Yuan S, Wu J, Guo Z, Shen Y, Wang J, Tang C
International immunopharmacology 2024 Jan 25;127:111423
International immunopharmacology 2024 Jan 25;127:111423
Activation of sigma-1 receptor ameliorates sepsis-induced myocardial injury by mediating the Nrf2/HO1 signaling pathway to attenuate mitochondrial oxidative stress.
Li Z, Zhou J, Cui S, Hu S, Li B, Liu X, Zhang C, Zou Y, Hu Y, Yu Y, Shen B, Yang B
International immunopharmacology 2024 Jan 25;127:111382
International immunopharmacology 2024 Jan 25;127:111382
Liensinine alleviates mouse intestinal injury induced by sepsis through inhibition of oxidative stress, inflammation, and cell apoptosis.
Wang G, Ma F, Xie K, Li X, Tan X, Xia Y, Wang Y, Dong J
International immunopharmacology 2024 Jan 25;127:111335
International immunopharmacology 2024 Jan 25;127:111335
Bardoxolone methyl breaks the vicious cycle between M1 macrophages and senescent nucleus pulposus cells through the Nrf2/STING/NF-κB pathway.
Wang P, Zhang S, Liu W, Lv X, Wang B, Hu B, Shao Z
International immunopharmacology 2024 Jan 25;127:111262
International immunopharmacology 2024 Jan 25;127:111262
Prothymosin α accelerates dengue virus-induced thrombocytopenia.
Yang ML, Lin CL, Chen YC, Lu IA, Su BH, Chen YH, Liu KT, Wu CL, Shiau AL
iScience 2024 Jan 19;27(1):108422
iScience 2024 Jan 19;27(1):108422
Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets.
Cui C, Wei Y, Wang Y, Ma W, Zheng X, Wang J, Ma Z, Wu C, Chu L, Zhang S, Guan W, Chen F
Journal of animal science and biotechnology 2024 Jan 19;15(1):4
Journal of animal science and biotechnology 2024 Jan 19;15(1):4
The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin.
Hua Q, Ren L
Chinese medicine 2024 Jan 18;19(1):12
Chinese medicine 2024 Jan 18;19(1):12
Neutrophil extracellular trap-related mechanisms in acne vulgaris inspire a novel treatment strategy with adipose-derived stem cells.
Yu H, Zhang B, Zhan Y, Yi Y, Jiang Q, Zhang Q, Wu Y, Wu M
Scientific reports 2024 Jan 17;14(1):1521
Scientific reports 2024 Jan 17;14(1):1521
Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis.
Rezzani R, Gianò M, Pinto D, Rinaldi F, van Noorden CJF, Favero G
International journal of molecular sciences 2024 Jan 16;25(2)
International journal of molecular sciences 2024 Jan 16;25(2)
Modified Qing-Zao-Jiu-Fei decoction attenuated pulmonary fibrosis induced by bleomycin in rats via modulating Nrf2/NF-κB and MAPKs pathways.
Zhu JQ, Tian YY, Chan KL, Hu Z, Xu QQ, Lin ZX, Xian YF
Chinese medicine 2024 Jan 16;19(1):10
Chinese medicine 2024 Jan 16;19(1):10
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes.
Zhao Z, Du JF, Wang QL, Qiu FN, Li P, Jiang Y, Li HJ
Chemical research in toxicology 2024 Jan 15;37(1):57-71
Chemical research in toxicology 2024 Jan 15;37(1):57-71
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Li Y, Li L, Xiong W, Duan X, Xi H
Theriogenology 2024 Jan 15;214:192-200
Theriogenology 2024 Jan 15;214:192-200
Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.
Wu DZ, Zhu GZ, Zhao K, Gao JW, Cai GX, Li HZ, Huang YS, Tu C, Zhuang JS, Huang ZW, Zhong ZM
Molecular medicine (Cambridge, Mass.) 2024 Jan 12;30(1):10
Molecular medicine (Cambridge, Mass.) 2024 Jan 12;30(1):10
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, Wang ZL, Wu XW, Cao ZR, Hua SY, Yin L, Shi L, Liang T
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
Integrated proteomics and metabolomics reveals metabolism disorders in the α-syn mice and potential therapeutic effect of Acanthopanax senticosus extracts.
Fu J, Gao X, Lu Y, Lu F, Wang Y, Chen P, Wang C, Yuan C, Liu S
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116878
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116878
Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway.
Zhao CB, Chen WB, Wang WZ, Gong FX, Fan CQ, Li Y, Lan T, Wang WJ, Yuan MZ
Asian journal of andrology 2024 Jan 1;26(1):57-66
Asian journal of andrology 2024 Jan 1;26(1):57-66
Costunolide attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease.
Wang J, Jin B, Chen Y, Chen Y, Zuo W, Huang L, Lin J, Jiang Y, Xie L, Lian X, Wang Y
Drug development research 2024 Feb;85(1):e22150
Drug development research 2024 Feb;85(1):e22150
4-octyl itaconate ameliorates ventilator-induced lung injury.
Wang X, Kong W, Yang R, Yang C
Archives of biochemistry and biophysics 2024 Feb;752:109853
Archives of biochemistry and biophysics 2024 Feb;752:109853
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.
Deen AJ, Adinolfi S, Härkönen J, Patinen T, Liu X, Laitinen T, Takabe P, Kainulainen K, Pasonen-Seppänen S, Gawriyski LM, Arasu UT, Selvarajan I, Mäkinen P, Laitinen H, Kansanen E, Kaikkonen MU, Poso A, Varjosalo M, Levonen AL
Redox biology 2024 Feb;69:103031
Redox biology 2024 Feb;69:103031
Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma.
Zhao Y, Zhu S
Biochemical genetics 2024 Feb;62(1):144-155
Biochemical genetics 2024 Feb;62(1):144-155
Targeting Ferroptosis Promotes Functional Recovery by Mitigating White Matter Injury Following Acute Carbon Monoxide Poisoning.
Wang S, Xiong B, Tian Y, Hu Q, Jiang X, Zhang J, Chen L, Wang R, Li M, Zhou X, Zhang T, Ge H, Yu A
Molecular neurobiology 2024 Feb;61(2):1157-1174
Molecular neurobiology 2024 Feb;61(2):1157-1174
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C
International journal of molecular medicine 2024 Feb;53(2)
International journal of molecular medicine 2024 Feb;53(2)
Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3β-Nrf2 signal cascade.
Yang F, Lian Q, Zhang X, Sun F, Jia S, Zhao W
Toxicology and applied pharmacology 2024 Feb;483:116829
Toxicology and applied pharmacology 2024 Feb;483:116829
hPMSCs Regulate the Level of TNF-α and IL-10 in Th1 Cells and Improve Hepatic Injury in a GVHD Mouse Model via CD73/ADO/Fyn/Nrf2 Axis.
Zhang H, Han K, Li H, Zhang J, Zhao Y, Wu Y, Wang B, Ma J, Luan X
Inflammation 2024 Feb;47(1):244-263
Inflammation 2024 Feb;47(1):244-263
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.
Yang F, Jia L, Zhou HC, Huang JN, Hou MY, Liu FT, Prabhu N, Li ZJ, Yang CB, Zou C, Nordlund P, Wang JG, Dai LY
Acta pharmacologica Sinica 2024 Feb;45(2):391-404
Acta pharmacologica Sinica 2024 Feb;45(2):391-404
Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway.
Li XN, Shang NY, Kang YY, Sheng N, Lan JQ, Tang JS, Wu L, Zhang JL, Peng Y
Acta pharmacologica Sinica 2024 Feb;45(2):248-267
Acta pharmacologica Sinica 2024 Feb;45(2):248-267
Epigallocatechin-3-gallate promotes wound healing response in diabetic mice by activating keratinocytes and promoting re-epithelialization.
Ning Y, Yuan Z, Wang Q, He J, Zhu W, Ren DN, Wo D
Phytotherapy research : PTR 2024 Feb;38(2):1013-1027
Phytotherapy research : PTR 2024 Feb;38(2):1013-1027
Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: From mechanism to therapy.
Huang X, Deng Y, Xiao J, Wang H, Yang Q, Cao Z
Bioactive materials 2024 Feb;32:473-487
Bioactive materials 2024 Feb;32:473-487
Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice.
Guo X, Liu M, Han B, Zheng Y, Zhang K, Bao G, Gao C, Shi H, Sun Q, Zhao Z
Biochemical pharmacology 2024 Feb;220:116009
Biochemical pharmacology 2024 Feb;220:116009
4-octyl itaconate protects against oxidative stress-induced liver injury by activating the Nrf2/Sirt3 pathway through AKT and ERK1/2 phosphorylation.
Hu Z, Xu D, Meng H, Liu W, Zheng Q, Wang J
Biochemical pharmacology 2024 Feb;220:115992
Biochemical pharmacology 2024 Feb;220:115992
Dimerized sesquiterpenoid [4 + 2] adducts with ferroptosis-promoting activity from Inula britannica Linn.
Guo C, Geng HJ, Wang WJ, Liu YX, Deng L, Tian JM, Gao JM, Tang JJ
Phytochemistry 2024 Feb;218:113951
Phytochemistry 2024 Feb;218:113951
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
Zhang W, Sun J, Liu F, Li S, Wang X, Su L, Liu G
Biological trace element research 2024 Feb;202(2):624-642
Biological trace element research 2024 Feb;202(2):624-642
Fructus Ligustri Lucidi inhibits ferroptosis in ovariectomy‑induced osteoporosis in rats via the Nrf2/HO‑1 signaling pathway.
Li P, Wang Y, Yan Q, Yang Y, Zhu R, Ma J, Chen Y, Liu H, Zhang Z
Biomedical reports 2024 Feb;20(2):27
Biomedical reports 2024 Feb;20(2):27
Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
Liu Y, Li TQ, Bai J, Liu WL, Wang ZR, Feng C, Pu LL, Wang XX, Liu H
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166977
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166977
Downregulation of TET2 Contributes to Nasal Polypogenesis Through Hypoxia-Inducible Factor 1α-Mediated Epithelial-to-Mesenchymal Transition.
Liu K, Xu Y
Clinical and experimental otorhinolaryngology 2024 Feb;17(1):64-77
Clinical and experimental otorhinolaryngology 2024 Feb;17(1):64-77
Characteristic alkaloids from Stemona sessilifolia with lung protective effects.
Jiang W, Liu B, Chen G, Wei L, Zhou D, Wang Y, Gui Y, Wang C, Yang Y, Sun L, Li N
Bioorganic chemistry 2024 Feb;143:107033
Bioorganic chemistry 2024 Feb;143:107033
Gut microbiome-based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from Selaginella uncinata (Desv.) Spring against inflammatory bowel disease.
Hui H, Wang Z, Zhao X, Xu L, Yin L, Wang F, Qu L, Peng J
Journal of pharmaceutical analysis 2024 Feb;14(2):177-195
Journal of pharmaceutical analysis 2024 Feb;14(2):177-195
Apigenin promotes apoptosis of 4T1 cells through PI3K/AKT/Nrf2 pathway and improves tumor immune microenvironment in vivo.
Zhang C, Liao Y, Li T, Zhong H, Shan L, Yu P, Xia C, Xu L
Toxicology research 2024 Feb;13(1):tfae011
Toxicology research 2024 Feb;13(1):tfae011
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Peng D, Huang Z, Yang H, Luo Y, Wu Z
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Immunity, inflammation and disease 2024 Feb;12(2):e1189
4-amino-2-trifluoromethyl-phenyl retinate alleviates lipopolysaccharide-induced acute myocardial injury through activation of the KLF4/p62 axis.
Dan Z, Shi X, Shu C, Zhu R, Wang Y, Zhu H
Cellular signalling 2024 Feb;114:111001
Cellular signalling 2024 Feb;114:111001
Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling.
Zhang JB, Wang F, Tang YT, Pang MZ, Li D, Liu CF
ACS chemical neuroscience 2024 Feb 7;15(3):572-581
ACS chemical neuroscience 2024 Feb 7;15(3):572-581
Catalpol Promotes Osseointegration of Titanium Implants under Conditions of Type 2 Diabetes via AKT/GSK3β/FYN Pathway-Mediated NRF2 Activation.
Zhang Y, Zhang J, Sun B, Ma L, Ma Y
ACS omega 2024 Feb 6;9(5):5761-5771
ACS omega 2024 Feb 6;9(5):5761-5771
Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway.
Wu M, Liu X, Yu Q, Shi J, Guo W, Zhang S
European journal of pharmacology 2024 Feb 5;964:176224
European journal of pharmacology 2024 Feb 5;964:176224
Rapid Discovery of Aβ(42) Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer's Disease.
Li QM, Han HH, Zang DD, Zha XQ, Zhou A, Zhang FY, Luo JP
Journal of agricultural and food chemistry 2024 Feb 28;72(8):4127-4141
Journal of agricultural and food chemistry 2024 Feb 28;72(8):4127-4141
Chemical Characterization of Honeysuckle Polyphenols and Their Alleviating Function on Ultraviolet B-Damaged HaCaT Cells by Modulating the Nrf2/NF-κB Signaling Pathways.
Zheng SL, Wang YM, Chi CF, Wang B
Antioxidants (Basel, Switzerland) 2024 Feb 28;13(3)
Antioxidants (Basel, Switzerland) 2024 Feb 28;13(3)
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC.
Li J, Shi D, Li S, Shi X, Liu Y, Zhang Y, Wang G, Zhang C, Xia T, Piao HL, Liu HX
Cell death & disease 2024 Feb 27;15(2):175
Cell death & disease 2024 Feb 27;15(2):175
Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice.
Xiong Y, Liu X, Jiang L, Hao T, Wang Y, Li T
Journal of translational medicine 2024 Feb 24;22(1):199
Journal of translational medicine 2024 Feb 24;22(1):199
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Zheng Z, Shang X, Sun K, Hou Y, Zhang X, Xu J, Liu H, Ruan Z, Hou L, Guo Z, Wang G, Xu F, Guo F
Free radical biology & medicine 2024 Feb 20;212:336-348
Free radical biology & medicine 2024 Feb 20;212:336-348
The neuroprotective effect of LCZ696 on methamphetamine-induced cognitive impairment in mice.
Qian L, Ruan Y, Gong X, Yu Z, Lin S, Li X, Shen Y, Luo H, Si Z, Liu Y
Neuroscience letters 2024 Feb 16;823:137630
Neuroscience letters 2024 Feb 16;823:137630
Isofraxidin attenuates dextran sulfate sodium-induced ulcerative colitis through inhibiting pyroptosis by upregulating Nrf2 and reducing reactive oxidative species.
He S, Zhang T, Wang YY, Yuan W, Li L, Li J, Yang YY, Wu DM, Xu Y
International immunopharmacology 2024 Feb 15;128:111570
International immunopharmacology 2024 Feb 15;128:111570
Gamma-oryzanol alleviates osteoarthritis development by targeting Keap1-Nrf2 binding to interfere with chondrocyte ferroptosis.
Dai ZH, Zhou CC, Yu CY, Qian CJ, Jin SQ, Du SQ, Lv YY, Jin C, Zheng G, Zhan Y
International immunopharmacology 2024 Feb 15;128:111469
International immunopharmacology 2024 Feb 15;128:111469
1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature.
Tonelotto V, Costa-Garcia M, O'Reilly E, Smith KF, Slater K, Dillon ET, Pendino M, Higgins C, Sist P, Bosch R, Passamonti S, Piulats JM, Villanueva A, Tramer F, Vanella L, Carey M, Kennedy BN
Cell death discovery 2024 Feb 10;10(1):70
Cell death discovery 2024 Feb 10;10(1):70
Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation.
Hu Y, Nan Y, Lin H, Zhao Q, Chen T, Tao X, Ding B, Lu L, Chen S, Zhu J, Guo X, Lin Z
Pediatric research 2024 Dec;96(7):1681-1692
Pediatric research 2024 Dec;96(7):1681-1692
Fluorescent gold nanoclusters possess multiple actions against atherosclerosis.
Lee YN, Wu YJ, Su CH, Wang BJ, Yang SH, Lee HI, Chou YH, Tien TY, Lin CF, Chan WH, Chung CH, Wang SW, Yeh HI
Redox biology 2024 Dec;78:103427
Redox biology 2024 Dec;78:103427
Pharmacological USP2 targeting suppresses ovarian cancer growth by potentiating apoptosis and ferroptosis.
Yang D, Liu X, Yang Y, Long Y, Nan D, Shi B, Wang J, Yang M, Cong H, Xing L, Zhou F, Yuan Q, Ta N, Zhang Y, Ma R, Liu F, Liu S
Archives of biochemistry and biophysics 2024 Dec;762:110193
Archives of biochemistry and biophysics 2024 Dec;762:110193
Inhibition of CDGSH iron‑sulfur domain 2 exhibits tumor-suppressing effects on diffuse large B-cell lymphoma (DLBCL) by inducing ferroptosis through the regulation of the NRF2/SLC7A11/GPX4 pathway.
Zhang J, Wang T, Zhang H, Li N, Liu B, Fang L
Toxicology and applied pharmacology 2024 Dec;493:117148
Toxicology and applied pharmacology 2024 Dec;493:117148
TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2.
Li Y, Guo X, Zhan P, Huang S, Chen J, Zhou Y, Jiang W, Chen L, Lin Z
Inflammation 2024 Dec;47(6):2041-2056
Inflammation 2024 Dec;47(6):2041-2056
Reserpine alleviates cisplatin-induced acute kidney injury via anti-ferroptosis and cGAS/STING pathway.
Xu N, Mu R, Deng S, Han Y, Shi Y, Fu X, Li H, Yao Q
Renal failure 2024 Dec;46(2):2406395
Renal failure 2024 Dec;46(2):2406395
Chrysophanol-mediated trx-1 activation attenuates renal fibrosis through inhibition of the JNK/Cx43 signaling pathway.
Bao N, Wang J, Yue Q, Cao F, Gu X, Wen K, Kong W, Gu M
Renal failure 2024 Dec;46(2):2398710
Renal failure 2024 Dec;46(2):2398710
Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway.
Du L, Guo C, Zeng S, Yu K, Liu M, Li Y
Renal failure 2024 Dec;46(2):2377785
Renal failure 2024 Dec;46(2):2377785
Nanoparticles transfected with plasmid-encoded lncRNA-OIP5-AS1 inhibit renal ischemia-reperfusion injury in mice via the miR-410-3p/Nrf2 axis.
Zhang R, Zhang X, Zhu X, Li T, Li Y, Zhang P, Chen Y, Li G, Han X
Renal failure 2024 Dec;46(1):2319327
Renal failure 2024 Dec;46(1):2319327
CircYTHDF1/miR-19b-3p/YTHDF1 axis contributes to pregnancy-induced hypertension development by enhancing vascular endothelial cell injury.
Wang F, Yang Q, Wang X, Guo Y, Lin S
Hypertension in pregnancy 2024 Dec;43(1):2414976
Hypertension in pregnancy 2024 Dec;43(1):2414976
Exposure to Polypropylene Microplastics Causes Cardiomyocyte Apoptosis Through Oxidative Stress and Activation of the MAPK-Nrf2 Signaling Pathway.
Lu T, Yuan X, Sui C, Yang C, Li D, Liu H, Zhang G, Li G, Li S, Zhang J, Zhou L, Xu M
Environmental toxicology 2024 Dec;39(12):5371-5381
Environmental toxicology 2024 Dec;39(12):5371-5381
Rivaroxaban Combined with Atorvastatin Inhibits Acute Pulmonary Embolism by Promoting the Expression of NRF2/NQO1.
Chen Y, Fan C, Wang J, Jiang M
Cardiovascular drugs and therapy 2024 Dec;38(6):1271-1287
Cardiovascular drugs and therapy 2024 Dec;38(6):1271-1287
Procyanidin B1 Promotes PSMC3-NRF2 Ubiquitination to Induce Ferroptosis in Glioblastoma.
Gao W, Li Y, Lin X, Deng K, Long X, Li D, Huang M, Wang X, Xu Y, She X, Wu M
Phytotherapy research : PTR 2024 Dec;38(12):5583-5597
Phytotherapy research : PTR 2024 Dec;38(12):5583-5597
Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway.
Hu R, Wu F, Zheng YQ
Redox report : communications in free radical research 2024 Dec;29(1):2332038
Redox report : communications in free radical research 2024 Dec;29(1):2332038
Regulation of LAMTOR1 by oxidative stress in retinal pigment epithelium: Implications for age-related macular degeneration pathogenesis.
Cai J, Liao F, Mao Y, Liu S, Wu X, Tang S, Wang S, Shan G, Wu S
Experimental eye research 2024 Dec;249:110129
Experimental eye research 2024 Dec;249:110129
Sulforaphane acts through the NFE2L2/AMPK signaling pathway to protect boar spermatozoa from cryoinjury by activating antioxidant defenses.
Zhang G, Wen F, Li Y, Sun P, Li Y, Hu Z, Wang H, Ma Y, Liang G, Chen L, Yang K, Hu J
Theriogenology 2024 Dec;230:330-340
Theriogenology 2024 Dec;230:330-340
Oleanolic acid promotes porcine oocyte maturation by activating the Nrf2/HO-1 signalling pathway.
Wang YQ, Dong YW, Qu HX, Qi JJ, Yan CX, Wei HK, Sun H, Sun BX, Liang S
Theriogenology 2024 Dec;230:203-211
Theriogenology 2024 Dec;230:203-211
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
Zhao Y, Zheng G, Yang S, Liu S, Wu Y, Miao Y, Liang Z, Hua Y, Zhang J, Shi J, Li D, Cheng Y, Zhang Y, Chen Y, Fan G, Ma C
British journal of pharmacology 2024 Dec;181(23):4822-4844
British journal of pharmacology 2024 Dec;181(23):4822-4844
Protective Effect of Acteoside against Hydrogen Peroxide-Induced Oxidative Damage in Human Corneal Epithelial Cells.
Huang Y, Peng Q
Bulletin of experimental biology and medicine 2024 Dec;178(2):213-217
Bulletin of experimental biology and medicine 2024 Dec;178(2):213-217
Baliosperoid A attenuates lipopolysaccharide-induced acute lung injury by targeting SHP2 to inhibit inflammation and oxidative stress.
Li Y, Zhao L, Liu Z, Chen Y, Li X, Zhu D, Liu L
Bioorganic chemistry 2024 Dec;153:107982
Bioorganic chemistry 2024 Dec;153:107982
Discovery of novel 5-phenyl-1H-pyrrole-2-carboxylic acids as Keap1-Nrf2 inhibitors for acute lung injury treatment.
Tang J, Tie X, Zhi S, Wang Z, Zhao Q, Qu Z, Lu G, Li Q, Wu Y, Shi Y
Bioorganic chemistry 2024 Dec;153:107741
Bioorganic chemistry 2024 Dec;153:107741
Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway.
Liu Y, Wang Y, Wang J, Wang X, Chen L, Han T, Lian H, Gan M, Wang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156143
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156143
Dang-Gui-Bu-Xue decoction against diabetic nephropathy via modulating the carbonyl compounds metabolic profile and AGEs/RAGE pathway.
Zhang ZT, Qi Y, Chen P, Chen L, Jiang Y, Fan Z, Guan H, Bai L, Liu J, Zhao D, Yan G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156104
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156104
Osmundacetone ameliorates Alzheimer's-like pathologies by inhibiting β-amyloid fibrillation, oxidative damage and neuroinflammation in APP/PS1 transgenic mice.
Zhao LX, Ren H, Su JY, Zhang Q, He DL, Wu TY, Zhang YH, Wang ZY, Fan YG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156091
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156091
Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway.
Li W, Zhong Y, Lin Z, Deng Z, Long D, Li M, Li C, Mao G, Kang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156052
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156052
Inhibition of ubiquitin-specific protease 7 ameliorates ferroptosis-mediated myocardial infarction by contrasting oxidative stress: An in vitro and in vivo analysis.
Yang D, Zhang T, Qu H, Li S, Lu J, Cao W, Chen Z, Zhang H, Yang J, Wang J
Cellular signalling 2024 Dec;124:111423
Cellular signalling 2024 Dec;124:111423
Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC-1α-mediated Transcriptional Coactivation.
Duan C, Li B, Liu H, Zhang Y, Yao X, Liu K, Wu X, Mao X, Wu H, Xu Z, Zhong Y, Hu Z, Gong Y, Xu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2408945
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2408945
Role of hypoxia-inducible-factor-1α (HIF-1α) in ferroptosis of adipose tissue during ketosis.
Fan Y, Ma L, Fang X, Du S, Mauck J, Loor JJ, Sun X, Jia H, Xu C, Xu Q
Journal of dairy science 2024 Dec;107(12):10611-10627
Journal of dairy science 2024 Dec;107(12):10611-10627
Dietary Bacillus subtilis benefits meat quality by regulating the muscle fiber type and antioxidant capacity of broilers.
Wang H, Xiao C, Li J, Liang R, Liu Y, Song Z, Buyse J, Zhu L
Poultry science 2024 Dec;103(12):104267
Poultry science 2024 Dec;103(12):104267
Spatheliachromen mitigates methylglyoxal-induced myotube atrophy by activating Nrf2, inhibiting ubiquitin-mediated protein degradation, and restoring mitochondrial function.
Chuang YF, Cheng L, Chang WH, Yu SY, Hsu HT, An LM, Yen CH, Chang FR, Lo YC
European journal of pharmacology 2024 Dec 5;984:177070
European journal of pharmacology 2024 Dec 5;984:177070
Gypenoside A-loaded mPEG-PLGA nanoparticles ameliorate high-glucose-induced retinal microvasculopathy by inhibiting ferroptosis.
Chen Q, Qiu FS, Xie W, Yu WY, Su ZA, Qin GM, Kang YK, Jiang SL, Yu CH
International journal of pharmaceutics 2024 Dec 5;666:124758
International journal of pharmaceutics 2024 Dec 5;666:124758
Investigating the potential risk of cadmium exposure on seizure severity and anxiety-like behaviors through the ferroptosis pathway in epileptic mice: An integrated multi-omics approach.
Chang Y, Jiang X, Dou J, Xie R, Zhao W, Cao Y, Gao J, Yao F, Wu D, Mei H, Zhong Y, Ge Y, Xu H, Jiang W, Xiao X, Jiang Y, Hu S, Wu Y, Liu Y
Journal of hazardous materials 2024 Dec 5;480:135814
Journal of hazardous materials 2024 Dec 5;480:135814
Albiflorin inhibits osteoclastogenesis and titanium particles-induced osteolysis via inhibition of ROS accumulation and the PI3K/AKT signaling pathway.
Wang Q, Tao H, Wang H, Chen K, Zhu P, Chen W, Shi F, Gu Y, Xu Y, Geng D
International immunopharmacology 2024 Dec 5;142(Pt B):113245
International immunopharmacology 2024 Dec 5;142(Pt B):113245
Triphala ameliorates cognitive deficits and anxiety via activation of the Nrf2/HO-1 axis in chronic sleep-deprived mice.
Wang W, He M, Rangji C, Yu S, Long P, Zhang Y, Wen X
International immunopharmacology 2024 Dec 5;142(Pt B):113179
International immunopharmacology 2024 Dec 5;142(Pt B):113179
Corydaline attenuates osteolysis in rheumatoid arthritis via mitigating reactive oxygen species production and suppressing calcineurin-Nfatc1 signaling.
Lu Q, Wang H, Zhang X, Yuan T, Wang Y, Feng C, Li Z, Sun S
International immunopharmacology 2024 Dec 5;142(Pt B):113158
International immunopharmacology 2024 Dec 5;142(Pt B):113158
Cardioprotective effect of Saussurea involucrata injection against Doxorubicin-induced cardiotoxicity by network pharmacology analysis and experimental verification.
Wang D, Jin Y, Yang M, Xue Y, Zhang X, Guo Y, Li X, Ma K
Acta biochimica et biophysica Sinica 2024 Dec 4;57(4):554-568
Acta biochimica et biophysica Sinica 2024 Dec 4;57(4):554-568
Prevention of bleomycin-induced pulmonary fibrosis by vaccination with the Tocilizumab mimotope.
Guo J, Yang L, Song H, Bai L
Human vaccines & immunotherapeutics 2024 Dec 31;20(1):2319965
Human vaccines & immunotherapeutics 2024 Dec 31;20(1):2319965
Colon-targeted engineered postbiotics nanoparticles alleviate osteoporosis through the gut-bone axis.
Yu T, Bai R, Wang Z, Qin Y, Wang J, Wei Y, Zhao R, Nie G, Han B
Nature communications 2024 Dec 30;15(1):10893
Nature communications 2024 Dec 30;15(1):10893
CRL3(Keap1) E3 ligase facilitates ubiquitin-mediated degradation of oncogenic SRX to suppress colorectal cancer progression.
Zhu F, Li L, Chen Y, Pan Y, Zhang W, Li L, Cai L, Zhao X, Zhao H, Wang S, Jia L
Nature communications 2024 Dec 3;15(1):10536
Nature communications 2024 Dec 3;15(1):10536
Screening of orthopedic medicines identifies raloxifene hydrochloride as a novel ferroptosis inhibitor for spinal cord injury therapy.
Su S, Wu X, Zhu Y, Yang S, Lu K, Zhang X, Zhang D, Wang X
International immunopharmacology 2024 Dec 25;143(Pt 3):113542
International immunopharmacology 2024 Dec 25;143(Pt 3):113542
Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects.
Wu CY, Wang KQ, Qin YY, Wang HW, Wu MM, Zhu XD, Lu XY, Zhu MM, Lu CS, Hu QQ
International immunopharmacology 2024 Dec 25;143(Pt 2):113490
International immunopharmacology 2024 Dec 25;143(Pt 2):113490
Nicotinamide adenine dinucleotide phosphate alleviates intestinal ischemia/reperfusion injury via Nrf2/HO-1 pathway.
Chen SY, Xu H, Qin Y, He TQ, Shi RR, Xing YR, Xu J, Cong RC, Wang MR, Yang JS, Gu JH, He BS
International immunopharmacology 2024 Dec 25;143(Pt 2):113478
International immunopharmacology 2024 Dec 25;143(Pt 2):113478
Ruscogenin attenuates osteoarthritis by modulating oxidative stress-mediated macrophage reprogramming via directly targeting Sirt3.
Liu Y, Li W, Tang H, Yang Z, Wei M, Zhou W, Li Z, Huang W
International immunopharmacology 2024 Dec 25;143(Pt 1):113336
International immunopharmacology 2024 Dec 25;143(Pt 1):113336
Isolicoflavonol ameliorates acute liver injury via inhibiting NLRP3 inflammasome activation through boosting Nrf2 signaling in vitro and in vivo.
Zhang XJ, Pu YK, Yang PY, Wang MR, Zhang RH, Li XL, Xiao WL
International immunopharmacology 2024 Dec 25;143(Pt 1):113233
International immunopharmacology 2024 Dec 25;143(Pt 1):113233
African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation.
Gao H, Gu T, Gao X, Song Z, Liu J, Song Y, Zhang G, Sun Y
Veterinary research 2024 Dec 20;55(1):172
Veterinary research 2024 Dec 20;55(1):172
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
Qi XM, Zhang WZ, Zuo YQ, Qiao YB, Zhang YL, Ren JH, Li QS
Cell biology and toxicology 2024 Dec 20;41(1):2
Cell biology and toxicology 2024 Dec 20;41(1):2
1,2-Propanediol Attenuates Radiation-Induced HaCaT Cell Injury by Inhibiting Oxidative Stress.
Liu Y, Ren B, Liu Y, Li Q, Jin J, Wu CT, Zhou G, Jin J
Biomedical and environmental sciences : BES 2024 Dec 20;37(12):1447-1452
Biomedical and environmental sciences : BES 2024 Dec 20;37(12):1447-1452
Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro.
Shimasaki M, Ueda S, Sakurai M, Kawahara N, Ueda Y, Ichiseki T
Biomolecules 2024 Dec 20;14(12)
Biomolecules 2024 Dec 20;14(12)
Effects of Bifidobacterium and rosuvastatin on metabolic-associated fatty liver disease via the gut-liver axis.
Ran X, Wang YJ, Li SG, Dai CB
Lipids in health and disease 2024 Dec 18;23(1):401
Lipids in health and disease 2024 Dec 18;23(1):401
myCAF-derived exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment.
Fang H, Dai W, Gu R, Zhang Y, Li J, Luo W, Tong S, Han L, Wang Y, Jiang C, Wang X, Wang R, Cai G
Journal of hematology & oncology 2024 Dec 18;17(1):126
Journal of hematology & oncology 2024 Dec 18;17(1):126
Carbon dots encapsulated zeolitic imidazolate framework-8 as an enhanced multi-antioxidant for efficient cytoprotection to HK-2 cells.
Zhou S, Cai H, Tang Z, Lu S
Journal of colloid and interface science 2024 Dec 15;676:726-738
Journal of colloid and interface science 2024 Dec 15;676:726-738
Oligomeric Proanthocyanidins Ameliorate Cadmium-Induced Senescence of Osteocytes Through Combating Oxidative Stress and Inflammation.
Yu G, Wang Z, Gong A, Fu X, Chen N, Zhou D, Li Y, Liu Z, Tong X
Antioxidants (Basel, Switzerland) 2024 Dec 12;13(12)
Antioxidants (Basel, Switzerland) 2024 Dec 12;13(12)
Effects of ginger root extract on cognitive impairment and the Nrf2/GPX4/SLC7A11 signaling pathway in aluminum-exposed rats.
Qin L, Jiang X, Wei Y, Xie J, Yang L
Metabolic brain disease 2024 Dec 11;40(1):60
Metabolic brain disease 2024 Dec 11;40(1):60
Downregulation of chemoresistance by claudin-14 silencing in human colorectal cancer cells.
Mizukami Y, Ito A, Hashimoto S, Ando T, Ishikawa Y, Eguchi H, Yoshino Y, Matsunaga T, Ikari A
Archives of biochemistry and biophysics 2024 Aug;758:110075
Archives of biochemistry and biophysics 2024 Aug;758:110075
ABCC1 deficiency potentiated noise-induced hearing loss in mice by impairing cochlear antioxidant capacity.
Liu J, Bai Y, Feng Y, Liu X, Pang B, Zhang S, Jiang M, Chen A, Huang H, Chen Y, Ling J, Mei L
Redox biology 2024 Aug;74:103218
Redox biology 2024 Aug;74:103218
IFP35 aggravates Staphylococcus aureus infection by promoting Nrf2-regulated ferroptosis.
Dai M, Ouyang W, Yu Y, Wang T, Wang Y, Cen M, Yang L, Han Y, Yao Y, Xu F
Journal of advanced research 2024 Aug;62:143-154
Journal of advanced research 2024 Aug;62:143-154
GOLPH3 inhibits erastin-induced ferroptosis in colorectal cancer cells.
Chen L, Wang C, Chen X, Wu Y, Chen M, Deng X, Qiu C
Cell biology international 2024 Aug;48(8):1198-1211
Cell biology international 2024 Aug;48(8):1198-1211
Osthole exhibits the remedial potential for polycystic ovary syndrome mice through Nrf2-Foxo1-GSH-NF-κB pathway.
Jin S, Wang YS, Huang JC, Wang TT, Li BY, Guo B, Yue ZP
Cell biology international 2024 Aug;48(8):1111-1123
Cell biology international 2024 Aug;48(8):1111-1123
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling.
Dong J, Che J, Wu Y, Deng Y, Jiang X, He Z, Zhang J
Cellular oncology (Dordrecht, Netherlands) 2024 Aug;47(4):1459-1474
Cellular oncology (Dordrecht, Netherlands) 2024 Aug;47(4):1459-1474
Mesenchymal Stromal Cell Therapy Alleviates Ovalbumin-Induced Chronic Airway Remodeling by Suppressing M2 Macrophage Polarization.
Yu H, Zhu G, Qin Q, Wang X, Guo X, Gu W
Inflammation 2024 Aug;47(4):1298-1312
Inflammation 2024 Aug;47(4):1298-1312
Glutamine Mitigates Oxidative Stress-Induced Matrix Degradation, Ferroptosis, and Pyroptosis in Nucleus Pulposus Cells via Deubiquitinating and Stabilizing Nrf2.
Wu J, Han W, Zhang Y, Li S, Qin T, Huang Z, Zhang C, Shi M, Wu Y, Zheng W, Gao B, Xu K, Ye W
Antioxidants & redox signaling 2024 Aug;41(4-6):278-295
Antioxidants & redox signaling 2024 Aug;41(4-6):278-295
Ezetimibe ketone protects against renal ischemia-reperfusion injury and attenuates oxidative stress via activation of the Nrf2/HO-1 signaling pathway.
Chen Z, Wang K, He X, Xue D, Ma X
Journal of biochemical and molecular toxicology 2024 Aug;38(8):e23792
Journal of biochemical and molecular toxicology 2024 Aug;38(8):e23792
Crebanine mitigates glucocorticoid-induced osteonecrosis of the femoral head by restoring bone remodelling homeostasis via attenuating oxidative stress.
Dong S, Ge J, Meng Q, Yuan T, Wang Y, Li Y, Lu Q, Song W, Li Z, Sun S
Journal of cellular and molecular medicine 2024 Aug;28(16):e70044
Journal of cellular and molecular medicine 2024 Aug;28(16):e70044
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
Xue Q, Li J, Qin R, Li M, Li Y, Zhang J, Wang R, Goltzman D, Miao D, Yang R
Aging cell 2024 Aug;23(8):e14202
Aging cell 2024 Aug;23(8):e14202
Hydroxygenkwanin exerts a neuroprotective effect by activating the Nrf2/ARE signaling pathway.
Osama A, Wu J, Nie Q, Song ZL, Zhang L, Gao J, Zhang B
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Aug;190:114842
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Aug;190:114842
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Cao H, Zhao L, Yuan Y, Liao C, Zeng W, Li A, Huang Q, Zhao Y, Fan Y, Jiang L, Song D, Li S, Zhang B
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Exosomes From Muscle-Derived Stem Cells Repair Peripheral Nerve Injury by Inhibiting Ferroptosis via the Keap1-Nrf2-Ho-1 Axis.
Liu Z, Zeng X, Bian W, Li H, Tegeleqi B, Gao Z, Liu J
Journal of cellular biochemistry 2024 Aug;125(8):e30614
Journal of cellular biochemistry 2024 Aug;125(8):e30614
Herpotrichone A Exerts Neuroprotective Effects by Relieving Ferroptosis.
Deng JL, Wang GY, Zhai YJ, Feng XY, Deng L, Han WB, Tang JJ
Journal of agricultural and food chemistry 2024 Aug 7;72(31):17356-17367
Journal of agricultural and food chemistry 2024 Aug 7;72(31):17356-17367
Brown adipose tissue-derived FGF21 mediates the cardioprotection of dexmedetomidine in myocardial ischemia/reperfusion injury.
Ding Y, Su J, Shan B, Fu X, Zheng G, Wang J, Wu L, Wang F, Chai X, Sun H, Zhang J
Scientific reports 2024 Aug 7;14(1):18292
Scientific reports 2024 Aug 7;14(1):18292
Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT.
Yamauchi T, Okano Y, Terada D, Yasukochi S, Tsuruta A, Tsurudome Y, Ushijima K, Matsunaga N, Koyanagi S, Ohdo S
Cancer & metabolism 2024 Aug 7;12(1):23
Cancer & metabolism 2024 Aug 7;12(1):23
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.
Dong Y, Kang H, Peng R, Liu Z, Liao F, Hu SA, Ding W, Wang P, Yang P, Zhu M, Wang S, Wu M, Ye D, Gan X, Li F, Song K
Cell metabolism 2024 Aug 6;36(8):1679-1695.e6
Cell metabolism 2024 Aug 6;36(8):1679-1695.e6
Vaccarin suppresses diabetic nephropathy through inhibiting the EGFR/ERK1/2 signaling pathway.
Zhu X, Meng X, Du X, Zhao C, Ma X, Wen Y, Zhang S, Hou B, Cai W, Du B, Han Z, Xu F, Qiu L, Sun H
Acta biochimica et biophysica Sinica 2024 Aug 27;56(12):1860-1874
Acta biochimica et biophysica Sinica 2024 Aug 27;56(12):1860-1874
Hsp90α promotes chemoresistance in pancreatic cancer by regulating Keap1-Nrf2 axis and inhibiting ferroptosis.
Liu B, Chen Z, Li Z, Zhao X, Zhang W, Zhang A, Wen L, Wang X, Zhou S, Qian D
Acta biochimica et biophysica Sinica 2024 Aug 22;57(2):295-309
Acta biochimica et biophysica Sinica 2024 Aug 22;57(2):295-309
Mitigation of ROS-triggered endoplasmic reticulum stress by upregulating Nrf2 retards diabetic nephropathy.
Zeng X, Zhang Y, Tian L, Zheng Y, Zhang J, Wu Z
Biochemical and biophysical research communications 2024 Aug 20;721:149972
Biochemical and biophysical research communications 2024 Aug 20;721:149972
Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy.
Yang S, Zhu Y, Shi Y, Su S, Liang H, Li S, Wu Z, Miao J, Chen Y, Zhang X, Wang X
Free radical biology & medicine 2024 Aug 20;221:245-256
Free radical biology & medicine 2024 Aug 20;221:245-256
TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.
Hu Y, Zou W, Zhang L, Zhang S, Hu L, Song Z, Kong S, Gao Y, Zhang J, Yang Y, Zheng J
Free radical biology & medicine 2024 Aug 20;221:155-168
Free radical biology & medicine 2024 Aug 20;221:155-168
Inhaled aerosolized algal polysaccharides: A novel and reliable strategy for treating pneumonia through inflammation and oxidative stress inhibition.
Zhang X, Lv D, Li B, Ding Y
International immunopharmacology 2024 Aug 20;137:112532
International immunopharmacology 2024 Aug 20;137:112532
Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2/HO-1 pathways.
Chen J, Zhu X, Wang Z, Rützler M, Lu Q, Xu H, Andersson R, Dai Y, Shen Z, Calamita G, Xie S, Bai Y, Chen B
International immunopharmacology 2024 Aug 20;137:112450
International immunopharmacology 2024 Aug 20;137:112450
Biochanin A: Disrupting the inflammatory vicious cycle for dry eye disease.
Chen T, Zhou N, Liang Q, Li Q, Li B, Chu Y, Zhang D, Chen Z, Tsao JR, Feng X, Hu K
European journal of pharmacology 2024 Aug 15;977:176583
European journal of pharmacology 2024 Aug 15;977:176583
Construction of mitochondrial-targeting nano-prodrug for enhanced Rhein delivery and treatment for osteoarthritis in vitro.
Huang H, Yang L, He H, Zhou B, Qin Z, Zheng L, Shen C
International journal of pharmaceutics 2024 Aug 15;661:124397
International journal of pharmaceutics 2024 Aug 15;661:124397
Tricetin protects against liver fibrosis through promoting autophagy and Nrf2 signaling in hepatic stellate cells.
Li W, Lv R, Zou T, Chen M
Life sciences 2024 Aug 15;351:122798
Life sciences 2024 Aug 15;351:122798
Nrf2 expression, mitochondrial fission, and neuronal apoptosis in the prefrontal cortex of methamphetamine abusers and rats.
Nie QY, Yang GM, Zhang P, Dong WJ, Jing D, Hou ZP, Peng YX, Yu Y, Li LH, Hong SJ
Brain research 2024 Aug 15;1837:148973
Brain research 2024 Aug 15;1837:148973
Sofalcone attenuates neurodegeneration in MPTP-induced mouse model of Parkinson's disease by inhibiting oxidative stress and neuroinflammation.
Chen M, He X, Fan Y, Xia L, Dong Z
Molecular biology reports 2024 Aug 14;51(1):908
Molecular biology reports 2024 Aug 14;51(1):908
Mesenchymal stem cell-derived extracellular vesicles mitigate neuronal damage from intracerebral hemorrhage by modulating ferroptosis.
Yang Y, Gao L, Xi J, Liu X, Yang H, Luo Q, Xie F, Niu J, Meng P, Tian X, Wu X, Long Q
Stem cell research & therapy 2024 Aug 13;15(1):255
Stem cell research & therapy 2024 Aug 13;15(1):255
Salvia miltiorrhiza suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling.
Wu YT, Zhang GY, Li L, Liu B, Wang RY, Song RQ, Hua Y, Bi YM, Han X, Zhang F, Wang D, Xie LP, Zhou YC
Journal of ethnopharmacology 2024 Aug 10;330:118214
Journal of ethnopharmacology 2024 Aug 10;330:118214
Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.
Kong L, Liu Y, Li J, Wang Y, Ji P, Shi Q, Han M, Xu H, Li W, Li W
Journal of ethnopharmacology 2024 Aug 10;330:118205
Journal of ethnopharmacology 2024 Aug 10;330:118205
Redox Balance and Inflammatory Response in Follicular Fluids of Women Recovered by SARS-CoV-2 Infection or Anti-COVID-19 Vaccinated: A Combined Metabolomics and Biochemical Study.
Castiglione Morelli MA, Iuliano A, Viggiani L, Matera I, Pistone A, Schettini SCA, Colucci P, Ostuni A
International journal of molecular sciences 2024 Aug 1;25(15)
International journal of molecular sciences 2024 Aug 1;25(15)
Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells.
Dai W, Xu B, Ding L, Zhang Z, Yang H, He T, Liu L, Pei X, Fu X
Free radical biology & medicine 2024 Aug 1;220:1-14
Free radical biology & medicine 2024 Aug 1;220:1-14
Amino acid deprivation induces TXNIP expression by NRF2 downregulation.
Ahn SH, Jang SK, Kim YJ, Kim G, Park KS, Park IC, Jin HO
IUBMB life 2024 Apr;76(4):212-222
IUBMB life 2024 Apr;76(4):212-222
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.
Yang Y, Ren J, Zhang J, Shi H, Wang J, Yan Y
Redox biology 2024 Apr;70:103067
Redox biology 2024 Apr;70:103067
Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages.
Wu Y, Gong X, Shen J, Zhu K
Journal of advanced research 2024 Apr;58:117-128
Journal of advanced research 2024 Apr;58:117-128
SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke.
Li J, Wei G, Song Z, Chen Z, Gu J, Zhang L, Wang Z
Neurochemical research 2024 Apr;49(4):998-1007
Neurochemical research 2024 Apr;49(4):998-1007
Cichoric acid targets RANKL to inhibit osteoclastogenesis and prevent ovariectomy-induced bone loss.
Xian Y, Gao Y, Su Y, Su Y, Lian H, Feng X, Liu Z, Zhao J, Xu J, Liu Q, Song F
Phytotherapy research : PTR 2024 Apr;38(4):1971-1989
Phytotherapy research : PTR 2024 Apr;38(4):1971-1989
CD44-targeted melanin-based nanoplatform for alleviation of ischemia/reperfusion-induced acute kidney injury.
Sun J, Zhao X, Shen H, Dong J, Rong S, Cai W, Zhang R
Journal of controlled release : official journal of the Controlled Release Society 2024 Apr;368:1-14
Journal of controlled release : official journal of the Controlled Release Society 2024 Apr;368:1-14
Pseudolaric acid B exerts an antifungal effect and targets SIRT1 to ameliorate inflammation by regulating Nrf2/NF-κB pathways in fungal keratitis.
Liu S, Qin T, Zou F, Dong H, Yu L, Wang H, Zhang L
Inflammopharmacology 2024 Apr;32(2):1133-1146
Inflammopharmacology 2024 Apr;32(2):1133-1146
APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy.
Du Y, Zhou Y, Yan X, Pan F, He L, Guo Z, Hu Z
Cell death and differentiation 2024 Apr;31(4):431-446
Cell death and differentiation 2024 Apr;31(4):431-446
SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress.
Luo J, Li P, Dong M, Zhang Y, Lu S, Chen M, Zhou H, Lin N, Jiang H, Wang Y
Cell death and differentiation 2024 Apr;31(4):417-430
Cell death and differentiation 2024 Apr;31(4):417-430
Therapeutic effect and mechanism of action of pterostilbene nano drugs in dry eye models.
Li K, Lin M, Huang K, Han J, Wei L, Miao L, Chen H, Gong Q, Li X, Hu L
Experimental eye research 2024 Apr;241:109836
Experimental eye research 2024 Apr;241:109836
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Liu J, Duangjan C, Irwin RW, Curran SP
Mechanisms of ageing and development 2024 Apr;218:111914
Mechanisms of ageing and development 2024 Apr;218:111914
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
Li Q, Kang J, Liu N, Huang J, Zhang X, Pang K, Zhang S, Wang M, Zhao Y, Dong S, Li H, Zhao D, Lu F, Zhang W
Free radical biology & medicine 2024 Apr;216:118-138
Free radical biology & medicine 2024 Apr;216:118-138
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
Xu Y, Sun D, Xiong L, Zhang Z, Li Y, Liu K, Li H, Chen L
Bioorganic chemistry 2024 Apr;145:107190
Bioorganic chemistry 2024 Apr;145:107190
ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.
Qian Z, Xia M, Zhao T, Li Y, Li G, Zhang Y, Li H, Yang L
Clinical and translational medicine 2024 Apr;14(4):e1661
Clinical and translational medicine 2024 Apr;14(4):e1661
Glutathione Depletion-Induced Versatile Nanomedicine for Potentiating the Ferroptosis to Overcome Solid Tumor Radioresistance and Enhance Immunotherapy.
Song H, Sun H, He N, Xu C, Du L, Ji K, Wang J, Zhang M, Gu Y, Wang Y, Liu Q
Advanced healthcare materials 2024 Apr;13(9):e2303412
Advanced healthcare materials 2024 Apr;13(9):e2303412
Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2/xCT/GPX4 signaling pathway.
Deng Y, Chu X, Li Q, Zhu G, Hu J, Sun J, Zeng H, Huang J, Ge G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155458
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155458
Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction.
Cai F, Li D, Zhou K, Zhang W, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155407
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155407
Very low-carbohydrate diet with higher protein ratio improves lipid metabolism and inflammation in rats with diet-induced nonalcoholic fatty liver disease.
Wu IT, Yeh WJ, Huang WC, Yang HY
The Journal of nutritional biochemistry 2024 Apr;126:109583
The Journal of nutritional biochemistry 2024 Apr;126:109583
Alginate oligosaccharide alleviates vascular aging by upregulating glutathione peroxidase 7.
Wang S, Yu Y, Liu J, Hu S, Shi S, Feng W, Mao Y
The Journal of nutritional biochemistry 2024 Apr;126:109578
The Journal of nutritional biochemistry 2024 Apr;126:109578
A NRF2 Regulated and the Immunosuppressive Microenvironment Reversed Nanoplatform for Cholangiocarcinoma Photodynamic-Gas Therapy.
Wang W, Gao Y, Xu J, Zou T, Yang B, Hu S, Cheng X, Xia Y, Zheng Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307143
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307143
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429
Communications biology 2024 Apr 9;7(1):429
Hesperidin ameliorates H(2)O(2)-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway.
Huang Q, Liu J, Peng C, Han X, Tan Z
Journal of animal science and biotechnology 2024 Apr 9;15(1):57
Journal of animal science and biotechnology 2024 Apr 9;15(1):57
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
Zeng Q, Wen BB, Liu X, Luo YY, Hu ZG, Huang L, Zhang XH, Huang XT, Zhou TT, Sang XX, Luo YY, Xiong DY, Luo ZQ, Liu W, Tang SY
Chinese medicine 2024 Apr 8;19(1):60
Chinese medicine 2024 Apr 8;19(1):60
A Flavonoid Glycoside Compound from Siraitia grosvenorii with Anti-Inflammatory and Hepatoprotective Effects In Vitro.
Wu J, Huang H, Gong L, Tian X, Peng Z, Zhu Y, Wang W
Biomolecules 2024 Apr 7;14(4)
Biomolecules 2024 Apr 7;14(4)
Guben Qingfei decoction attenuates LPS-induced acute lung injury by modulating the TLR4/NF-κB and Keap1/Nrf2 signaling pathways.
Zeng Z, Fu Y, Li M, Shi Y, Ding Q, Chen S
Journal of ethnopharmacology 2024 Apr 6;323:117674
Journal of ethnopharmacology 2024 Apr 6;323:117674
Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling.
Zhang ZT, Liang QF, Wang X, Wang RS, Duan TT, Wang SM, Tang D
Journal of ethnopharmacology 2024 Apr 6;323:117647
Journal of ethnopharmacology 2024 Apr 6;323:117647
NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury.
Huang Y, Li X, Wei L, Ma S, Ma L, Zan Y, He X, Tang Y, Ding Y
Biology direct 2024 Apr 29;19(1):32
Biology direct 2024 Apr 29;19(1):32
Neuroprotective effect of acetoxypachydiol against oxidative stress through activation of the Keap1-Nrf2/HO-1 pathway.
Qi Y, Liu G, Jin S, Jian R, Zou Z, Wang C, Zhang Y, Zhao M, Zhu H, Yan P
BMC complementary medicine and therapies 2024 Apr 25;24(1):175
BMC complementary medicine and therapies 2024 Apr 25;24(1):175
Differences in Airway Remodeling and Emphysematous Lesions between Rats Exposed to Smoke from New-Type and Conventional Tobacco Varieties.
Wei K, Li Y, Du B, Wu J
Antioxidants (Basel, Switzerland) 2024 Apr 24;13(5)
Antioxidants (Basel, Switzerland) 2024 Apr 24;13(5)
Investigating the role of itaconate in macrophage activation and oxidative stress injury in sepsis-associated acute kidney injury.
Yang L, Zhou P, Li R, Yin Y, Xie G, Shi L, Zhang P, Tao K
Molecular biology reports 2024 Apr 20;51(1):533
Molecular biology reports 2024 Apr 20;51(1):533
The role of FPR2-mediated ferroptosis in formyl peptide-induced acute lung injury against endothelial barrier damage and protective effect of the mitochondria-derived peptide MOTS-c.
Wen Z, Fan J, Zhan F, Li X, Li B, Lu P, Yao X, Shen Z, Liu Z, Wang C, Li X, Jin W, Zhang X, Qi Y, Wang X, Song M
International immunopharmacology 2024 Apr 20;131:111911
International immunopharmacology 2024 Apr 20;131:111911
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789
International immunopharmacology 2024 Apr 20;131:111789
Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53.
Tang YJ, Zhang Z, Yan T, Chen K, Xu GF, Xiong SQ, Wu DQ, Chen J, Jose PA, Zeng CY, Fu JJ
Cardiovascular diabetology 2024 Apr 2;23(1):116
Cardiovascular diabetology 2024 Apr 2;23(1):116
Dysregulated VEGF/VEGFR-2 Signaling and Plexogenic Lesions in the Embryonic Lungs of Chickens Predisposed to Pulmonary Arterial Hypertension.
Ye L, Liu R, Li Q, Zhou C, Tan X
International journal of molecular sciences 2024 Apr 19;25(8)
International journal of molecular sciences 2024 Apr 19;25(8)
Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression.
Pan R, Wang R, Cheng F, Wang L, Cui Z, She J, Yang X
Reproductive biology and endocrinology : RB&E 2024 Apr 11;22(1):41
Reproductive biology and endocrinology : RB&E 2024 Apr 11;22(1):41
Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway.
Dong M, Yang Z, Gao Q, Deng Q, Li L, Chen H
Antioxidants (Basel, Switzerland) 2024 Apr 10;13(4)
Antioxidants (Basel, Switzerland) 2024 Apr 10;13(4)
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
Wogonin Diminishes Radioresistance of Breast Cancer via Inhibition of the Nrf2/HIF-1[Formula: see text] Pathway.
Wang T, Wang P, Wang S, Ma Y, Zhao Z, Long F
The American journal of Chinese medicine 2023;51(8):2243-2262
The American journal of Chinese medicine 2023;51(8):2243-2262
Quercetin Ameliorates Diabetic Kidney Injury by Inhibiting Ferroptosis via Activating Nrf2/HO-1 Signaling Pathway.
Feng Q, Yang Y, Qiao Y, Zheng Y, Yu X, Liu F, Wang H, Zheng B, Pan S, Ren K, Liu D, Liu Z
The American journal of Chinese medicine 2023;51(4):997-1018
The American journal of Chinese medicine 2023;51(4):997-1018
Ethylhexadecyldimethylammonium bromide, a quaternary ammonium compound, controls inflammatory response through NRF2 pathway in a human immortalized keratinocyte cell line.
Aubry L, Vallion R, Salman S, Damiens MH, Ferret PJ, Kerdine-Römer S
Frontiers in toxicology 2023;5:1132020
Frontiers in toxicology 2023;5:1132020
Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products.
Miyauchi Y, Koba H, Sawai M, Kansui H, Takechi S
The Journal of toxicological sciences 2023;48(5):263-272
The Journal of toxicological sciences 2023;48(5):263-272
N-acetyl cysteine inhibits IL-1α release from murine keratinocytes induced by 2-hydroxyethyl methacrylate.
Kaji T, Kuroishi T, Bando K, Takahashi M, Sugawara S
The Journal of toxicological sciences 2023;48(10):557-569
The Journal of toxicological sciences 2023;48(10):557-569
Nrf2 Expression Is Decreased in LRRK2 Transgenic Mouse Brain and LRRK2 Overexpressing SH-SY5Y Cells.
Kawakami F, Imai M, Tamaki S, Ohta E, Kawashima R, Maekawa T, Kurosaki Y, Ohba K, Ichikawa T
Biological & pharmaceutical bulletin 2023;46(1):123-127
Biological & pharmaceutical bulletin 2023;46(1):123-127
Butylphthalide improves brain damage induced by renal ischemia-reperfusion injury rats through Nrf2/HO-1 and NOD2/MAPK/NF-κB pathways.
Min J, Chen Q, Pan M, Liu T, Gu Q, Zhang D, Sun R
Renal failure 2023;45(2):2259234
Renal failure 2023;45(2):2259234
Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD).
Theys C, Vanderhaeghen T, Van Dijck E, Peleman C, Scheepers A, Ibrahim J, Mateiu L, Timmermans S, Vanden Berghe T, Francque SM, Van Hul W, Libert C, Vanden Berghe W
Frontiers in molecular medicine 2023;3:1283170
Frontiers in molecular medicine 2023;3:1283170
Detection of Ferroptosis by Immunohistochemistry and Immunofluorescence.
Zhong X, Chen R
Methods in molecular biology (Clifton, N.J.) 2023;2712:211-222
Methods in molecular biology (Clifton, N.J.) 2023;2712:211-222
OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.
Liu N, Fan Y, Li Y, Zhang Y, Li J, Wang Y, Wang Z, Liu Y, Li Y, Kang Z, Peng Y, Ru Z, Yang M, Feng C, Wang Y, Yang X
Current neuropharmacology 2023;21(12):2550-2562
Current neuropharmacology 2023;21(12):2550-2562
Pterostilbene Confers Protection against Diquat-Induced Intestinal Damage with Potential Regulation of Redox Status and Ferroptosis in Broiler Chickens.
Chen Y, Zhang H, Li Y, Wang T
Oxidative medicine and cellular longevity 2023;2023:8258354
Oxidative medicine and cellular longevity 2023;2023:8258354
JFD, a Novel Natural Inhibitor of Keap1 Alkylation, Suppresses Intracellular Mycobacterium Tuberculosis Growth through Keap1/Nrf2/SOD2-Mediated ROS Accumulation.
Wan H, Cai Y, Xiao L, Ling Y, Ge L, Mo S, Xie Q, Peng S, Zhou B, Zeng X, Chen X
Oxidative medicine and cellular longevity 2023;2023:6726654
Oxidative medicine and cellular longevity 2023;2023:6726654
Protective Effect of Alkaline Mineral Water on Calcium Oxalate-Induced Kidney Injury in Mice.
Liu L, Lin C, Li X, Cheng Y, Wang R, Luo C, Zhao X, Jiang Z
Evidence-based complementary and alternative medicine : eCAM 2023;2023:4559802
Evidence-based complementary and alternative medicine : eCAM 2023;2023:4559802
miR-432-5p Inhibits the Ferroptosis in Cardiomyocytes Induced by Hypoxia/Reoxygenation via Activating Nrf2/SLC7A11 Axis by Degrading Keap1.
Geng W, Yan S, Li X, Liu Q, Zhang X, Gu X, Tian X, Jiang Y
Analytical cellular pathology (Amsterdam) 2023;2023:1293200
Analytical cellular pathology (Amsterdam) 2023;2023:1293200
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses.
Chen F, Zhan J, Liu M, Mamun AA, Huang S, Tao Y, Zhao J, Zhang Y, Xu Y, He Z, Du S, Lu W, Li X, Chen Z, Xiao J
International journal of biological sciences 2023;19(13):4340-4359
International journal of biological sciences 2023;19(13):4340-4359
Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK/ARE/Nrf2 pathway.
Yamagishi N, Yamamoto Y, Nishi T, Ito T, Kanai Y
PloS one 2023;18(6):e0287788
PloS one 2023;18(6):e0287788
Probiotics attenuate valproate-induced liver steatosis and oxidative stress in mice.
Song W, Yan X, Zhai Y, Ren J, Wu T, Guo H, Song Y, Li X, Guo Y
PloS one 2023;18(11):e0294363
PloS one 2023;18(11):e0294363
Exploration of Artemisinin Against IgA Nephropathy via AKT/Nrf2 Pathway by Bioinformatics and Experimental Validation.
Yang WG, Sun A, Zhu R, Liu N, He WJ, Liu LL
Drug design, development and therapy 2023;17:1679-1697
Drug design, development and therapy 2023;17:1679-1697
Mastoparan M Suppressed NLRP3 Inflammasome Activation by Inhibiting MAPK/NF-κB and Oxidative Stress in Gouty Arthritis.
Yan Y, Yu L, Chen B, Cao C, Zhao H, Wang Q, Xie D, Xi Y, Zhang C, Cheng J
Journal of inflammation research 2023;16:6179-6193
Journal of inflammation research 2023;16:6179-6193
Dental Pulp Stem Cells Ameliorate Elastase-Induced Pulmonary Emphysema by Regulating Inflammation and Oxidative Stress.
Gao X, Liu Z, Wang Z
Journal of inflammation research 2023;16:1497-1508
Journal of inflammation research 2023;16:1497-1508
Shikimic acid (SA) inhibits neuro-inflammation and exerts neuroprotective effects in an LPS-induced in vitro and in vivo model.
Bao X, Zheng Z, Lv J, Bao J, Chang S, Jiang X, Xin Y
Frontiers in pharmacology 2023;14:1265571
Frontiers in pharmacology 2023;14:1265571
Fecal microbiota transplantation from HUC-MSC-treated mice alleviates acute lung injury in mice through anti-inflammation and gut microbiota modulation.
Hua F, Cui E, Lv L, Wang B, Li L, Lu H, Chen N, Chen W
Frontiers in microbiology 2023;14:1243102
Frontiers in microbiology 2023;14:1243102
Ursolic acid reduces oxidative stress injury to ameliorate experimental autoimmune myocarditis by activating Nrf2/HO-1 signaling pathway.
Fu Y, Liu T, He S, Zhang Y, Tan Y, Bai Y, Shi J, Deng W, Qiu J, Wang Z, Chen Y, Jin Q, Xie M, Wang J
Frontiers in pharmacology 2023;14:1189372
Frontiers in pharmacology 2023;14:1189372
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Zou YY, Tang XB, Chen ZL, Liu B, Zheng L, Song MY, Xiao Q, Zhou ZQ, Peng XY, Tang CF
Frontiers in endocrinology 2023;14:1162485
Frontiers in endocrinology 2023;14:1162485
Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway.
Chen T, Hu Y, Lu L, Zhao Q, Tao X, Ding B, Chen S, Zhu J, Guo X, Lin Z
Frontiers in pharmacology 2023;14:1134464
Frontiers in pharmacology 2023;14:1134464
Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis.
Liu X, Peng X, Cen S, Yang C, Ma Z, Shi X
Frontiers in pharmacology 2023;14:1129662
Frontiers in pharmacology 2023;14:1129662
Occlusion preconditioned mice are resilient to hypobaric hypoxia-induced myocarditis and arrhythmias due to enhanced immunomodulation, metabolic homeostasis, and antioxidants defense.
Adzika GK, Mprah R, Rizvi R, Adekunle AO, Ndzie Noah ML, Wowui PI, Adzraku SY, Adu-Amankwaah J, Wang F, Lin Y, Fu L, Liu X, Xiang J, Sun H
Frontiers in immunology 2023;14:1124649
Frontiers in immunology 2023;14:1124649
Ginsenoside ompound K reduces neuronal damage and improves neuronal synaptic dysfunction by targeting Aβ.
Li N, Pang Q, Zhang Y, Lin J, Li H, Li Z, Liu Y, Fang X, An Y, Bai H, Li D, Cao Z, Liu J, Yang Q, Hu S
Frontiers in pharmacology 2023;14:1103012
Frontiers in pharmacology 2023;14:1103012
Resolvin D1/N-formyl peptide receptor 2 ameliorates paclitaxel-induced neuropathic pain through the activation of IL-10/Nrf2/HO-1 pathway in mice.
Su CJ, Zhang JT, Zhao FL, Xu DL, Pan J, Liu T
Frontiers in immunology 2023;14:1091753
Frontiers in immunology 2023;14:1091753
Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway.
Lou L, Wang M, He J, Yang S, Meng F, Wang S, Jin X, Cai J, Cai C
Frontiers in pharmacology 2023;14:1067402
Frontiers in pharmacology 2023;14:1067402
Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal.
Kou Y, Rong X, Tang R, Zhang Y, Yang P, Liu H, Ma W, Li M
Frontiers in pharmacology 2023;14:1067085
Frontiers in pharmacology 2023;14:1067085
Pien-tze-huang promotes wound healing in streptozotocin-induced diabetes models associated with improving oxidative stress via the Nrf2/ARE pathway.
Liu Y, Mo J, Liang F, Jiang S, Xiong J, Meng X, Mo Z
Frontiers in pharmacology 2023;14:1062664
Frontiers in pharmacology 2023;14:1062664
Phellodendronoside A Exerts Anticancer Effects Depending on Inducing Apoptosis Through ROS/Nrf2/Notch Pathway and Modulating Metabolite Profiles in Hepatocellular Carcinoma.
Si Y, Hui C, Guo T, Liu M, Chen X, Dong C, Feng S
Journal of hepatocellular carcinoma 2023;10:935-948
Journal of hepatocellular carcinoma 2023;10:935-948
Inhibitory Effects of Esculetin on Liver Cancer Through Triggering NCOA4 Pathway-Mediation Ferritinophagy in vivo and in vitro.
Xiu Z, Li Y, Fang J, Han J, Li S, Li Y, Yang X, Song G, Li Y, Jin N, Zhu Y, Zhu G, Sun L, Li X
Journal of hepatocellular carcinoma 2023;10:611-629
Journal of hepatocellular carcinoma 2023;10:611-629
Identification of cuproptosis-related biomarkers and analysis of immune infiltration in allograft lung ischemia-reperfusion injury.
Qin J, Xiao X, Li S, Wen N, Qin K, Li H, Wu J, Lu B, Li M, Sun X
Frontiers in molecular biosciences 2023;10:1269478
Frontiers in molecular biosciences 2023;10:1269478
Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway.
Hong Y, Zhou X, Li Q, Chen J, Wei Y, Shen L, Long C, Wu S, Wei G
Toxicology in vitro : an international journal published in association with BIBRA 2023 Sep;91:105626
Toxicology in vitro : an international journal published in association with BIBRA 2023 Sep;91:105626
Methylglyoxal suppresses microglia inflammatory response through NRF2-IκBζ pathway.
Wei SL, Yang Y, Si WY, Zhou Y, Li T, Du T, Zhang P, Li XL, Duan RN, Duan RS, Yang CL
Redox biology 2023 Sep;65:102843
Redox biology 2023 Sep;65:102843
Carnosine alleviates kidney tubular epithelial injury by targeting NRF2 mediated ferroptosis in diabetic nephropathy.
Zhang S, Li Y, Liu X, Guo S, Jiang L, Huang Y, Wu Y
Amino acids 2023 Sep;55(9):1141-1155
Amino acids 2023 Sep;55(9):1141-1155
Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress.
Li X, Yi L, Liu X, Chen X, Chen S, Cai S
Transplantation proceedings 2023 Sep;55(7):1751-1761
Transplantation proceedings 2023 Sep;55(7):1751-1761
Effect of renal denervation on cardiac remodelling and function in rats with chronic intermittent hypoxia.
Lu D, Wang K, Jiang W, Zhang H, Zhang H
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):719-727
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):719-727
TGF-β3 Protects Neurons Against Intermittent Hypoxia-Induced Oxidative Stress and Apoptosis Through Activation of the Nrf-2/KEAP1/HO-1 Pathway via Binding to TGF-βRI.
Huang Y, Liu Z, Wang X, Li Y, Liu L, Li B
Neurochemical research 2023 Sep;48(9):2808-2825
Neurochemical research 2023 Sep;48(9):2808-2825
Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia.
Yamada M, Warabi E, Oishi H, Lira VA, Okutsu M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23156
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23156
Involvement of NADPH oxidases in the Na/K‑ATPase/Src/ROS oxidant amplification loop in renal fibrosis.
Zhang H, Lai F, Cheng X, Wang Y
Molecular medicine reports 2023 Sep;28(3)
Molecular medicine reports 2023 Sep;28(3)
Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation.
Li J, Zhang J, Xue Q, Liu B, Qin R, Li Y, Qiu Y, Wang R, Goltzman D, Miao D, Yang R
Aging cell 2023 Sep;22(9):e13912
Aging cell 2023 Sep;22(9):e13912
Aloe-emodin alleviates doxorubicin-induced cardiotoxicity via inhibition of ferroptosis.
He Y, Xi J, Fang J, Zhang B, Cai W
Free radical biology & medicine 2023 Sep;206:13-21
Free radical biology & medicine 2023 Sep;206:13-21
Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke.
Wang J, He P, Tian Q, Luo Y, He Y, Liu C, Gong P, Guo Y, Ye Q, Li M
Neural regeneration research 2023 Sep;18(9):2029-2036
Neural regeneration research 2023 Sep;18(9):2029-2036
Notopterol alleviates the progression of osteoarthritis: An in vitro and in vivo study.
Qu Y, Qiu L, Qiu H, Shen Y, Tang M, Huang Y, Peng Y, Wang J, Fu Q
Cytokine 2023 Sep;169:156309
Cytokine 2023 Sep;169:156309
Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis.
Yang XM, Wang XQ, Hu LP, Feng MX, Zhou YQ, Li DX, Li J, Miao XC, Zhang YL, Yao LL, Nie HZ, Huang S, Xia Q, Zhang XL, Jiang SH, Zhang ZG
Gastroenterology 2023 Sep;165(3):629-646
Gastroenterology 2023 Sep;165(3):629-646
Cynarin alleviates intervertebral disc degeneration via protecting nucleus pulposus cells from ferroptosis.
Zhang P, Rong K, Guo J, Cui L, Kong K, Zhao C, Yang H, Xu H, Qin A, Ma P, Yang X, Zhao J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115252
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115252
Berberine protects cyclophosphamide and busulfan-induced premature ovarian insufficiency in mouse model.
Peng Y, Sun L, Guo W, Liu Z, Wang T, Zou T, Zhou J, Yang X, Fan X
Journal of pharmacological sciences 2023 Sep;153(1):46-54
Journal of pharmacological sciences 2023 Sep;153(1):46-54
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.
Xiang X, Chen J, Jiang T, Yan C, Kang Y, Zhang M, Xiang K, Guo J, Jiang G, Wang C, XiangXu, Yang X, Chen Z
Drug delivery and translational research 2023 Sep;13(9):2286-2296
Drug delivery and translational research 2023 Sep;13(9):2286-2296
Pharmacological activation of the Nrf2 pathway by Taxifolin remodels articular cartilage microenvironment for the therapy of Osteoarthritis.
Jiang H, Yu J, Yan Z, Lin Z, Lin M, Mao Y, Hong Z, Lin J, Xue X, Pan X
International immunopharmacology 2023 Sep;122:110587
International immunopharmacology 2023 Sep;122:110587
Liensinine pretreatment reduces inflammation, oxidative stress, apoptosis, and autophagy to alleviate sepsis acute kidney injury.
Zhang W, Chen H, Xu Z, Zhang X, Tan X, He N, Shen J, Dong J
International immunopharmacology 2023 Sep;122:110563
International immunopharmacology 2023 Sep;122:110563
A Biomimetic Nanoparticle Exerting Protection against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS.
Yao Q, Tang Y, Dai S, Huang L, Jiang Z, Zheng S, Sun M, Xu Y, Lu R, Sun T, Huang H, Jiang X, Yao X, Lin G, Kou L, Chen R
Advanced healthcare materials 2023 Sep;12(24):e2300571
Advanced healthcare materials 2023 Sep;12(24):e2300571
FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
Tong G, Chen Y, Chen X, Fan J, Zhu K, Hu Z, Li S, Zhu J, Feng J, Wu Z, Hu Z, Zhou B, Jin L, Chen H, Shen J, Cong W, Li X
Nature communications 2023 Sep 30;14(1):6107
Nature communications 2023 Sep 30;14(1):6107
Cell state transition analysis identifies interventions that improve control of Mycobacterium tuberculosis infection by susceptible macrophages.
Yabaji SM, Rukhlenko OS, Chatterjee S, Bhattacharya B, Wood E, Kasaikina M, Kholodenko BN, Gimelbrant AA, Kramnik I
Science advances 2023 Sep 29;9(39):eadh4119
Science advances 2023 Sep 29;9(39):eadh4119
Antidiabetic Effect of Collagen Peptides from Harpadon nehereus Bones in Streptozotocin-Induced Diabetes Mice by Regulating Oxidative Stress and Glucose Metabolism.
Lin Q, Guo Y, Li J, He S, Chen Y, Jin H
Marine drugs 2023 Sep 29;21(10)
Marine drugs 2023 Sep 29;21(10)
δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis.
He X, Wang D, Yi Y, Tan Y, Wu M, Wang H, Hu W, Chen H, Zhang Q, Wu Y
Cell death discovery 2023 Sep 22;9(1):349
Cell death discovery 2023 Sep 22;9(1):349
Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression.
Zeng T, Li J, Xie L, Dong Z, Chen Q, Huang S, Xie S, Lai Y, Li J, Yan W, Wang Y, Xie Z, Hu C, Zhang J, Kuang S, Song Y, Gao L, Lv Z
Journal of neuroinflammation 2023 Sep 21;20(1):212
Journal of neuroinflammation 2023 Sep 21;20(1):212
FGF2 Rescued Cisplatin-Injured Granulosa Cells through the NRF2-Autophagy Pathway.
Wang L, Cheng F, Pan R, Cui Z, She J, Zhang Y, Yang X
International journal of molecular sciences 2023 Sep 18;24(18)
International journal of molecular sciences 2023 Sep 18;24(18)
Exploring anti-acute kidney injury mechanism of Dahuang-Gancao decoction by network pharmacology and experimental validation.
Wang R, An Y, Xu Y, Li C, Wang Q, Zou Y, Wang G
Aging 2023 Sep 18;15(19):10072-10088
Aging 2023 Sep 18;15(19):10072-10088
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Zhong G, Li Y, Li L, Huo Y, Zhang W, Li T, Ma F, Liao J, Li Y, Zhang H, Guo J, Pan J, Yu W, Hu L, Tang Z
Journal of hazardous materials 2023 Sep 15;458:131908
Journal of hazardous materials 2023 Sep 15;458:131908
Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis.
Hou L, Wang G, Zhang X, Lu F, Xu J, Guo Z, Lin J, Zheng Z, Liu H, Hou Y, Sun K, Guo F
iScience 2023 Sep 15;26(9):107647
iScience 2023 Sep 15;26(9):107647
The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism.
Oh M, Jang SY, Lee JY, Kim JW, Jung Y, Kim J, Seo J, Han TS, Jang E, Son HY, Kim D, Kim MW, Park JS, Song KH, Oh KJ, Kim WK, Bae KH, Huh YM, Kim SH, Kim D, Han BS, Lee SC, Hwang GS, Lee EW
Nature communications 2023 Sep 15;14(1):5728
Nature communications 2023 Sep 15;14(1):5728
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
Zhang L, Liang S, Zhang Z, Wang K, Cao J, Yao M, Qin L, Qu C, Miao J
International journal of molecular sciences 2023 Sep 12;24(18)
International journal of molecular sciences 2023 Sep 12;24(18)
Nuclear erythroid 2-related factor 2 protects against reactive oxygen species -induced preterm premature rupture of membranes through regulation of mitochondria†.
Zhang X, He X, Wei L, He Y, Li Y, Wang Y, Li C
Biology of reproduction 2023 Sep 12;109(3):330-339
Biology of reproduction 2023 Sep 12;109(3):330-339
Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation.
Tao M, Yan W, Chen C, Tang M, Zhao X, Feng Q, Fei X, Fu Y
Life sciences 2023 Sep 1;328:121847
Life sciences 2023 Sep 1;328:121847
Graphene oxide had adverse effects on sperm motility and morphology through oxidative stress.
Chen Q, Li L, Zhao J, Zhang Y, Xue X
Toxicology in vitro : an international journal published in association with BIBRA 2023 Oct;92:105653
Toxicology in vitro : an international journal published in association with BIBRA 2023 Oct;92:105653
Honokiol alleviates radiation-induced premature ovarian failure via enhancing Nrf2.
Xin L, Li F, Yu H, Xiong Q, Hou Q, Meng Y
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13769
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13769
Perillaldehyde Mitigates Ionizing Radiation-Induced Intestinal Injury by Inhibiting Ferroptosis via the Nrf2 Signaling Pathway.
Tang LF, Ma X, Xie LW, Zhou H, Yu J, Wang ZX, Li M
Molecular nutrition & food research 2023 Oct;67(19):e2300232
Molecular nutrition & food research 2023 Oct;67(19):e2300232
Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis.
Feng R, Liu J, Yang Z, Yao T, Ye P, Li X, Zhang J, Jiang H
Molecular neurobiology 2023 Oct;60(10):6001-6017
Molecular neurobiology 2023 Oct;60(10):6001-6017
Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia-reperfusion injury model of mice.
Wang ZS, Shu B, Han Q, Li GH, Guo YL
International urology and nephrology 2023 Oct;55(10):2599-2610
International urology and nephrology 2023 Oct;55(10):2599-2610
Anti-inflammatory activity of 2-methoxy-4-vinylphenol involves inhibition of lipopolysaccharide-induced inducible nitric oxidase synthase by heme oxygenase-1.
Asami E, Kitami M, Ida T, Kobayashi T, Saeki M
Immunopharmacology and immunotoxicology 2023 Oct;45(5):589-596
Immunopharmacology and immunotoxicology 2023 Oct;45(5):589-596
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway.
Wang X, Yang J, Wang W, Li Y, Yang Y
Immunopharmacology and immunotoxicology 2023 Oct;45(5):527-538
Immunopharmacology and immunotoxicology 2023 Oct;45(5):527-538
TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway.
Liang C, Zhang HY, Wang YQ, Yang LA, Du YS, Luo Y, Zhang TC, Xu Y
Current medical science 2023 Oct;43(5):1023-1032
Current medical science 2023 Oct;43(5):1023-1032
NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11.
Lin S, Cheng H, Yang G, Wang C, Leung CK, Zhang S, Tan Y, Zhang H, Wang H, Miao L, Li Y, Huang Y, Li J, Zhang R, Zeng X
Neurotoxicity research 2023 Oct;41(5):398-407
Neurotoxicity research 2023 Oct;41(5):398-407
Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase.
Liu L, Zhang Y, Wang L, Liu Y, Chen H, Hu Q, Xie C, Meng X, Shen X
Phytotherapy research : PTR 2023 Oct;37(10):4587-4606
Phytotherapy research : PTR 2023 Oct;37(10):4587-4606
SUMOylation of the ubiquitin ligase component KEAP1 at K39 upregulates NRF2 and its target function in lung cancer cell proliferation.
Yang H, Du Y, Fei X, Huang S, Yimiti M, Yang X, Ma J, Li S, Tuoheniyazi H, Zhao Y, Gu Z, Xu D
The Journal of biological chemistry 2023 Oct;299(10):105215
The Journal of biological chemistry 2023 Oct;299(10):105215
Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1/Nrf2 and inhibiting TLR4/NF-κB p65 pathways.
Tian J, Zhang S, Li L, Lin X, Li Y, Zhao K, Zheng F, Chen Y, Yang Y, Wu T, Pang J
Experimental biology and medicine (Maywood, N.J.) 2023 Oct;248(20):1864-1876
Experimental biology and medicine (Maywood, N.J.) 2023 Oct;248(20):1864-1876
Effects of dietary resveratrol supplementation in cattle on the anti-oxidative capacity and meat quality of beef steaks under high‑oxygen packaging.
Cui Y, Qi J, Li J, Zhang Y, Yang X, Xin L, Niu L, Xu B, Qian Z, Zhu L, Liang R
Meat science 2023 Oct;204:109238
Meat science 2023 Oct;204:109238
Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2/GPX4 pathway.
Pan M, Wang Z, Wang Y, Jiang X, Fan Y, Gong F, Sun Y, Wang D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115333
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115333
MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis.
Li C, Han S, Zhu J, Cheng F
Cellular signalling 2023 Oct;110:110801
Cellular signalling 2023 Oct;110:110801
Puerarin protects against acetaminophen-induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway.
Zhou W, He H, Wei Q, Che L, Zhao X, Liu W, Yan Y, Hu L, Du Y, Yin Z, Shuai Y, Yang L, Feng R
Food science & nutrition 2023 Oct;11(10):6604-6615
Food science & nutrition 2023 Oct;11(10):6604-6615
Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke.
Shaheryar ZA, Khan MA, Hameed H, Zaidi SAA, Anjum I, Rahman MSU
European journal of pharmacology 2023 Oct 5;956:175990
European journal of pharmacology 2023 Oct 5;956:175990
Citrus peel extract protects against diesel exhaust particle-induced chronic obstructive pulmonary disease-like lung lesions and oxidative stress.
Fang ZF, Fu Y, Peng Y, Song SR, Wang ZN, Yang Y, Nie YC, Han HL, Teng YB, Xiao WM, Chen JP, Zhou BJ, Ou GL, Xie JX, Liu XY, Zhang JJ, Zhong NS
Food & function 2023 Oct 30;14(21):9841-9856
Food & function 2023 Oct 30;14(21):9841-9856
Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis.
Xie W, Deng L, Lin M, Huang X, Qian R, Xiong D, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2023 Oct 29;12(11)
Antioxidants (Basel, Switzerland) 2023 Oct 29;12(11)
Paeoniflorin alleviates hypoxia/reoxygenation injury in HK-2 cells by inhibiting apoptosis and repressing oxidative damage via Keap1/Nrf2/HO-1 pathway.
Xing D, Ma Y, Lu M, Liu W, Zhou H
BMC nephrology 2023 Oct 26;24(1):314
BMC nephrology 2023 Oct 26;24(1):314
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394
Cell death discovery 2023 Oct 24;9(1):394
Potential regulatory role of the Nrf2/HMGB1/TLR4/NF-κB signaling pathway in lupus nephritis.
Li SJ, Ruan DD, Wu WZ, Wu M, Wu QY, Wang HL, Ji YY, Zhang YP, Lin XF, Fang ZT, Liao LS, Luo JW, Gao MZ, Wu JB
Pediatric rheumatology online journal 2023 Oct 23;21(1):130
Pediatric rheumatology online journal 2023 Oct 23;21(1):130
Conditional Dependency of LP-184 on Prostaglandin Reductase 1 is Synthetic Lethal in Pancreatic Cancers with DNA Damage Repair Deficiencies.
Restifo D, McDermott JR, Cvetkovic D, Dos Santos T, Ogier C, Surumbayeva A, Handorf EA, Schimke C, Ma C, Cai KQ, Olszanski AJ, Kathad U, Bhatia K, Sharma P, Kulkarni A, Astsaturov I
Molecular cancer therapeutics 2023 Oct 2;22(10):1182-1190
Molecular cancer therapeutics 2023 Oct 2;22(10):1182-1190
Eriocitrin inhibits epithelial-mesenchymal transformation (EMT) in lung adenocarcinoma cells via triggering ferroptosis.
Gao M, Lai K, Deng Y, Lu Z, Song C, Wang W, Xu C, Li N, Geng Q
Aging 2023 Oct 2;15(19):10089-10104
Aging 2023 Oct 2;15(19):10089-10104
Cyasterone ameliorates sepsis-related acute lung injury via AKT (Ser473)/GSK3β (Ser9)/Nrf2 pathway.
Lin M, Xie W, Xiong D, Tang S, Huang X, Deng L, Huang L, Zhang X, Zhou T, Qian R, Zeng Q, Sang X, Luo Y, Hua Q, Ren L, Liu W
Chinese medicine 2023 Oct 19;18(1):136
Chinese medicine 2023 Oct 19;18(1):136
A Study of Gentianae Radix et Rhizoma Class Differences Based on Chemical Composition and Core Efficacy.
Kou B, Jiang Y, Chen Y, Yang J, Sun J, Yan Y, Weng L, Xiao C
Molecules (Basel, Switzerland) 2023 Oct 17;28(20)
Molecules (Basel, Switzerland) 2023 Oct 17;28(20)
Verbascoside Elicits Its Beneficial Effects by Enhancing Mitochondrial Spare Respiratory Capacity and the Nrf2/HO-1 Mediated Antioxidant System in a Murine Skeletal Muscle Cell Line.
Sciandra F, Bottoni P, De Leo M, Braca A, Brancaccio A, Bozzi M
International journal of molecular sciences 2023 Oct 17;24(20)
International journal of molecular sciences 2023 Oct 17;24(20)
Partial Replacement of Diet with Dehulled Adlay Ameliorates Hepatic Steatosis, Inflammation, Oxidative Stress, and Gut Dysbiosis in Rats with Nonalcoholic Fatty Liver Disease.
Huang HC, Lee PN, Huang WC, Yang HY
Nutrients 2023 Oct 16;15(20)
Nutrients 2023 Oct 16;15(20)
High-sulfated derivative of polysaccharide from Ulva pertusa improves Adriamycin-induced nephrotic syndrome by suppressing oxidative stress.
Wan Y, Wang S, Chen K, Liu L, Wang X, Zhang B, Hu L, Liu S, Zhao T, Qi H
Food & function 2023 Oct 16;14(20):9167-9180
Food & function 2023 Oct 16;14(20):9167-9180
Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca(2+) pathways.
Cui Z, Gu L, Liu T, Liu Y, Yu B, Kou J, Li F, Yang K
European journal of pharmacology 2023 Oct 15;957:176044
European journal of pharmacology 2023 Oct 15;957:176044
Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia/reperfusion injury through PI3K/Akt-mediated Nrf2 signaling pathways.
Xie X, Wang F, Ge W, Meng X, Fan L, Zhang W, Wang Z, Ding M, Gu S, Xing X, Sun X
European journal of pharmacology 2023 Oct 15;957:175979
European journal of pharmacology 2023 Oct 15;957:175979
Effective myocardial infarction treatment by targeted accumulation of Sulforaphane using porous magnetic silica nanoparticles.
Zhang J, Dong Y, Liu X, Jin H, Wang S, An N, Wang L
International journal of pharmaceutics 2023 Oct 15;645:123389
International journal of pharmaceutics 2023 Oct 15;645:123389
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Liu J, Duangjan C, Irwin RW, Curran SP
bioRxiv : the preprint server for biology 2023 Oct 11;
bioRxiv : the preprint server for biology 2023 Oct 11;
Polydopamine-loaded prunetin nanomaterials activate DRD2 to reduce UV-induced inflammation by stabilizing and promoting Nrf2 nuclear translocation.
Han J, Zheng S, Jin J, Wu T, Shi Y, Yang K, Zhang H, Li Y, Sun Y, Lv Y, Yao C, Lin T, Zhu C, Liu H
Acta biomaterialia 2023 Oct 1;169:556-565
Acta biomaterialia 2023 Oct 1;169:556-565
Injectable microenvironment-responsive hydrogels with redox-activatable supramolecular prodrugs mediate ferroptosis-immunotherapy for postoperative tumor treatment.
Cheng Z, Xue C, Liu M, Cheng Z, Tian G, Li M, Xue R, Yao X, Zhang Y, Luo Z
Acta biomaterialia 2023 Oct 1;169:289-305
Acta biomaterialia 2023 Oct 1;169:289-305
The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress.
Qu L, Wang F, Ma X
Heliyon 2023 Nov;9(11):e21955
Heliyon 2023 Nov;9(11):e21955
Network pharmacology and in vivo studies reveal the neuroprotective effects of paeoniflorin on Alzheimer's disease.
Zhang M, Zheng H, He J, Zhang M
Heliyon 2023 Nov;9(11):e21800
Heliyon 2023 Nov;9(11):e21800
The novel β-TrCP protein isoform hidden in circular RNA confers trastuzumab resistance in HER2-positive breast cancer.
Wang S, Wang Y, Li Q, Li X, Feng X, Zeng K
Redox biology 2023 Nov;67:102896
Redox biology 2023 Nov;67:102896
Mechanisms underlying citrinin-induced toxicity via oxidative stress and apoptosis-mediated by mitochondrial-dependent pathway in SH-SY5Y cells.
Abudayyak M, Karaman EF, Ozden S
Drug and chemical toxicology 2023 Nov;46(5):944-954
Drug and chemical toxicology 2023 Nov;46(5):944-954
Orientin inhibits inflammation in chondrocytes and attenuates osteoarthritis through Nrf2/NF-κB and SIRT6/NF-κB pathway.
Xia W, Xiao J, Tong C, Lu J, Tu Y, Li S, Ni L, Shi Y, Luo P, Zhang X, Wang X
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Nov;41(11):2405-2417
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Nov;41(11):2405-2417
Propofol Pretreatment Inhibits Liver Damage in Mice with Hepatic Ischemia/Reperfusion Injury and Protects Human Hepatocyte in Hypoxia/Reoxygenation.
Li J, Wang R, Chen H, Yang Y, Yang X, Wang W
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2023 Nov;34(11):1171-1179
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2023 Nov;34(11):1171-1179
Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway.
Xuan LN, Hu ZX, Jiang ZF, Zhang C, Sun XW, Ming WH, Liu HT, Qiao RF, Shen LJ, Liu SB, Wang GY, Wen L, Luan ZL, Yin J
CNS neuroscience & therapeutics 2023 Nov;29(11):3460-3478
CNS neuroscience & therapeutics 2023 Nov;29(11):3460-3478
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Chen X, Chen J, Miao C, Yin G, Zhang Z, Sun R, Ni S
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
BRD2 protects the rat H9C2 cardiomyocytes from hypoxia‑reoxygenation injury by targeting Nrf2/HO‑1 signaling pathway.
Liu Y, Fu Y, Xue X, Tang G, Si L
Experimental and therapeutic medicine 2023 Nov;26(5):542
Experimental and therapeutic medicine 2023 Nov;26(5):542
Fucoidan promotes angiogenesis and accelerates wound healing through AKT/Nrf2/HIF-1α signalling pathway.
Wen W, Yang L, Wang X, Zhang H, Wu F, Xu K, Chen S, Liao Z
International wound journal 2023 Nov;20(9):3606-3618
International wound journal 2023 Nov;20(9):3606-3618
The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury.
Yu Z, Cheng X, Pan W, Yu C, Duan Y
Neural regeneration research 2023 Nov;18(11):2482-2488
Neural regeneration research 2023 Nov;18(11):2482-2488
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
Wang X, Wu H, An J, Zhang G, Chen Y, Fu L, Tao L, Liang G, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway.
Zhu X, Huang N, Ji Y, Sheng X, Huo J, Zhu Y, Huang M, He W, Ma J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115567
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115567
Engineering cannabidiol synergistic carbon monoxide nanocomplexes to enhance cancer therapy via excessive autophagy.
Xiao C, Sun Y, Fan J, Nguyen W, Chen S, Long Y, Chen W, Zhu A, Liu B
Acta pharmaceutica Sinica. B 2023 Nov;13(11):4591-4606
Acta pharmaceutica Sinica. B 2023 Nov;13(11):4591-4606
A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB pathway and activation Nrf2 pathway in macrophages.
Shen X, Chen H, Zhang H, Luo L, Wen T, Liu L, Hu Q, Wang L
International immunopharmacology 2023 Nov;124(Pt B):110965
International immunopharmacology 2023 Nov;124(Pt B):110965
BNTA attenuates temporomandibular joint osteoarthritis progression by directly targeting ALDH3A1: An in vivo and in vitro study.
He K, Lin H, Zhang S, Ou Y, Lu J, Chen W, Zhou Y, Li Y, Lin Y, Su J, Xing Y, Chen H, Chen J
International immunopharmacology 2023 Nov;124(Pt B):110963
International immunopharmacology 2023 Nov;124(Pt B):110963
Activation of Nrf2/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury.
Guo H, Chen J, Yu H, Dong L, Yu R, Li Q, Song J, Chen H, Zhang H, Pu J, Wang W
International immunopharmacology 2023 Nov;124(Pt A):110864
International immunopharmacology 2023 Nov;124(Pt A):110864
Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy.
Sandouka S, Singh PK, Saadi A, Taiwo RO, Sheeni Y, Zhang T, Deeb L, Guignet M, White SH, Shekh-Ahmad T
Journal of translational medicine 2023 Nov 8;21(1):796
Journal of translational medicine 2023 Nov 8;21(1):796
Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease.
Deng GH, Wu CF, Li YJ, Shi H, Zhong WC, Hong MK, Li JJ, Zhao JM, Liu C, Qin MC, Zeng ZY, Zhang WM, Yung KKL, Lv ZP, Gao L
Military Medical Research 2023 Nov 8;10(1):53
Military Medical Research 2023 Nov 8;10(1):53
High-fat stimulation induces atrial neural remodeling by reducing NO production via the CRIF1/eNOS/P21 axi.
Zhang A, Li H, Song Q, Cui Y, Zhang Y, Wang X, Li Z, Hou Y
Lipids in health and disease 2023 Nov 6;22(1):189
Lipids in health and disease 2023 Nov 6;22(1):189
Sulforaphane ameliorated podocyte injury according to regulation of the Nrf2/PINK1 pathway for mitophagy in diabetic kidney disease.
Wang Y, Xu Y, Wang Q, Guo F, Song Y, Fan X, Shao M, Chen D, Zhang W, Qin G
European journal of pharmacology 2023 Nov 5;958:176042
European journal of pharmacology 2023 Nov 5;958:176042
Compound 5 alleviated acute kidney injury without affecting the antitumor effect after cisplatin treatment.
Guo Y, Li X, Yuan R, Ren J, Huang Y, Tian H
Biochemical and biophysical research communications 2023 Nov 5;680:177-183
Biochemical and biophysical research communications 2023 Nov 5;680:177-183
Lactoferrin Alleviates Ethanol-Induced Injury via Promoting Nrf2 Nuclear Translocation in BRL-3A Rat Liver Cells.
Li D, Ding L, Yan Y, Xing Y, Xu J, Qin L
International journal of molecular sciences 2023 Nov 28;24(23)
International journal of molecular sciences 2023 Nov 28;24(23)
Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation.
Li JJ, Dai WQ, Mo WH, Xu WQ, Li YY, Guo CY, Xu XF
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1341-1354
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1341-1354
Ferrostatin-1 suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling.
Wu YT, Zhang GY, Hua Y, Fan HJ, Han X, Xu HL, Chen GH, Liu B, Xie LP, Zhou YC
The Journal of pharmacy and pharmacology 2023 Nov 23;75(11):1467-1477
The Journal of pharmacy and pharmacology 2023 Nov 23;75(11):1467-1477
Chlorogenic Acid Alleviated AFB1-Induced Hepatotoxicity by Regulating Mitochondrial Function, Activating Nrf2/HO-1, and Inhibiting Noncanonical NF-κB Signaling Pathway.
Wang Q, Liu T, Koci M, Wang Y, Fu Y, Ma M, Ma Q, Zhao L
Antioxidants (Basel, Switzerland) 2023 Nov 22;12(12)
Antioxidants (Basel, Switzerland) 2023 Nov 22;12(12)
Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO-1 Pathway in BMSCs and Ovariectomized Mice.
Lin BH, Ma RX, Wu JT, Du SQ, Lv YY, Yu HN, Zhang W, Mao SM, Liu GY, Bu YT, Chen ZH, Jin C, Wu ZY, Yang L
Journal of agricultural and food chemistry 2023 Nov 2;
Journal of agricultural and food chemistry 2023 Nov 2;
IL-17A promotes tumorigenesis and upregulates PD-L1 expression in non-small cell lung cancer.
Liao H, Chang X, Gao L, Ye C, Qiao Y, Xie L, Lin J, Cai S, Dong H
Journal of translational medicine 2023 Nov 17;21(1):828
Journal of translational medicine 2023 Nov 17;21(1):828
The protective effects of uric acid against myocardial ischemia via the Nrf2 pathway.
Ma P, Zhao M, Li Y, Zhang G, Ma Y, Shi Y, Su P, Chen R, Tang ZG, Zhang Y, Liu B, Zhang Q, Liu X, Li F
European journal of pharmacology 2023 Nov 15;959:176062
European journal of pharmacology 2023 Nov 15;959:176062
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Wang H, Liu X, Yang H, Jing X, Wang W, Liu X, Zhang B, Liu X, Shao Y, Cui X
Life sciences 2023 Nov 15;333:122162
Life sciences 2023 Nov 15;333:122162
Fucoxanthin alleviated myocardial ischemia and reperfusion injury through inhibition of ferroptosis via the NRF2 signaling pathway.
Yan J, Li Z, Liang Y, Yang C, Ou W, Mo H, Tang M, Chen D, Zhong C, Que D, Feng L, Xiao H, Song X, Yang P
Food & function 2023 Nov 13;14(22):10052-10068
Food & function 2023 Nov 13;14(22):10052-10068
Identification of OLA1 as a Novel Protein Target of Vitexin to Ameliorate Dextran Sulfate Sodium-Induced Colitis with Tissue Thermal Proteome Profiling.
Li N, Wang R, Li W, Du Q, Deng Z, Fan Y, Zheng L
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16057-16066
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16057-16066
Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis.
Li Y, Zhong G, He T, Quan J, Liu S, Liu Z, Tang Z, Yu W
Ecotoxicology and environmental safety 2023 Nov 1;266:115542
Ecotoxicology and environmental safety 2023 Nov 1;266:115542
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy.
Xu B, Zhou Z, Fang J, Wang J, Tao K, Liu J, Liu S
Free radical biology & medicine 2023 Nov 1;208:319-333
Free radical biology & medicine 2023 Nov 1;208:319-333
MAGL inhibition relieves synovial inflammation and pain via regulating NOX4-Nrf2 redox balance in osteoarthritis.
Li X, Tao H, Zhou J, Zhang L, Shi Y, Zhang C, Sun W, Chu M, Chen K, Gu C, Yang X, Geng D, Hao Y
Free radical biology & medicine 2023 Nov 1;208:13-25
Free radical biology & medicine 2023 Nov 1;208:13-25
Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36.
Zhu Z, Li X, Wang X, Zuo X, Ma Y, Gao X, Liang Z, Zhang Z, Song Z, Ding T, Ju C, Li P, Li K, Zhang J, Quan H, Wang Z, Hu X
Bioengineering & translational medicine 2023 May;8(3):e10473
Bioengineering & translational medicine 2023 May;8(3):e10473
A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies.
Härkönen J, Pölönen P, Deen AJ, Selvarajan I, Teppo HR, Dimova EY, Kietzmann T, Ahtiainen M, Väyrynen JP, Väyrynen SA, Elomaa H, Tynkkynen N, Eklund T, Kuopio T, Talvitie EM, Taimen P, Kallajoki M, Kaikkonen MU, Heinäniemi M, Levonen AL
Redox biology 2023 May;61:102644
Redox biology 2023 May;61:102644
Electrophilic reactive aldehydes as a therapeutic target in colorectal cancer prevention and treatment.
Gobert AP, Asim M, Smith TM, Williams KJ, Barry DP, Allaman MM, McNamara KM, Hawkins CV, Delgado AG, Zhao S, Piazuelo MB, Washington MK, Coburn LA, Rathmacher JA, Wilson KT
Oncogene 2023 May;42(20):1685-1691
Oncogene 2023 May;42(20):1685-1691
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Xi Y, Chi Z, Tao X, Zhai X, Zhao Z, Ren J, Yang S, Dong D
Environmental toxicology 2023 May;38(5):1153-1161
Environmental toxicology 2023 May;38(5):1153-1161
Curcumin protects against doxorubicin induced oxidative stress by regulating the Keap1-Nrf2-ARE and autophagy signaling pathways.
Liao D, Shangguan D, Wu Y, Chen Y, Liu N, Tang J, Yao D, Shi Y
Psychopharmacology 2023 May;240(5):1179-1190
Psychopharmacology 2023 May;240(5):1179-1190
Pgp3 protein of Chlamydia trachomatis inhibits apoptosis via HO-1 upregulation mediated by PI3K/Akt activation.
Shu M, Bu J, Lei W, Chen L, Zhou Z, Lu C, Chen C, Li Z
Microbial pathogenesis 2023 May;178:106056
Microbial pathogenesis 2023 May;178:106056
Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke.
Shih CC, Liao WC, Ke HY, Kuo CW, Tsao CM, Tsai WC, Chiu YL, Huang HC, Wu CC
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114565
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114565
Chrysin protects against cerebral ischemia-reperfusion injury in hippocampus via restraining oxidative stress and transition elements.
Shang J, Jiao J, Yan M, Wang J, Li Q, Shabuerjiang L, Lu Y, Song Q, Bi L, Huang G, Zhang X, Wen Y, Cui Y, Wu K, Li G, Wang P, Liu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114534
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114534
Epigallocatechin-3-gallate (EGCG) based metal-polyphenol nanoformulations alleviates chondrocytes inflammation by modulating synovial macrophages polarization.
Wei H, Qin J, Huang Q, Jin Z, Zheng L, Zhao J, Qin Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114366
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114366
C1q/tumor necrosis factor-related protein-9 exerts antioxidant and anti-inflammatory effects on oxygen-glucose deprivation/reoxygenation-stimulated neurons by modulating the Akt-GSK-3β-Nrf2 cascade via AdipoR1.
Wang J, Ren B, Yang Y, Li Y
International immunopharmacology 2023 May;118:110045
International immunopharmacology 2023 May;118:110045
Aescin can alleviate NAFLD through Keap1-Nrf2 by activating antioxidant and autophagy.
Yu H, Yan S, Jin M, Wei Y, Zhao L, Cheng J, Ding L, Feng H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154746
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154746
Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice.
Liu Y, Mi Y, Wang Y, Meng Q, Xu L, Liu Y, Zhou D, Wang Y, Liang D, Li W, Li N, Hou Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154729
DNMT3A R882H mutation promotes acute leukemic cell survival by regulating glycolysis through the NRF2/NQO1 axis.
Chu X, Zhong L, Dan W, Wang X, Zhang Z, Liu Z, Lu Y, Shao X, Zhou Z, Chen S, Liu B
Cellular signalling 2023 May;105:110626
Cellular signalling 2023 May;105:110626
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination.
Wang X, Zhou T, Yang X, Cao X, Jin G, Zhang P, Guo J, Rong K, Li B, Hu Y, Liu K, Ma P, Qin A, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2204438
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2204438
Red Ginseng Improves D-galactose-Induced Premature Ovarian Failure in Mice Based on Network Pharmacology.
Shang Z, Fan M, Zhang J, Wang Z, Jiang S, Li W
International journal of molecular sciences 2023 May 4;24(9)
International journal of molecular sciences 2023 May 4;24(9)
Lactoferrin Relieves Deoxynivalenol-Induced Oxidative Stress and Inflammatory Response by Modulating the Nrf2/MAPK Pathways in the Liver.
Hu P, Liu Y, Li S, Zhao Y, Gu H, Zong Q, Ahmed AA, Bao W, Liu HY, Cai D
Journal of agricultural and food chemistry 2023 May 31;71(21):8182-8191
Journal of agricultural and food chemistry 2023 May 31;71(21):8182-8191
Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway.
Zhang X, Wang S, Jin Y, Wang J, Wang R, Yang X, Zhang S, Yan T, Jia Y
Journal of ethnopharmacology 2023 May 23;308:116253
Journal of ethnopharmacology 2023 May 23;308:116253
Protective effect and mechanism of Lycium ruthenicum polyphenols against acrylamide-induced neurotoxicity.
Pang Y, Chen J, Yang J, Xue Y, Gao H, Gao Q
Food & function 2023 May 22;14(10):4552-4568
Food & function 2023 May 22;14(10):4552-4568
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1.
Zheng J, Zhang Q, Zhao Z, Qiu Y, Zhou Y, Wu Z, Jiang C, Wang X, Jiang X
Journal of experimental & clinical cancer research : CR 2023 May 19;42(1):127
Journal of experimental & clinical cancer research : CR 2023 May 19;42(1):127
Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth.
Zhao H, Zhang M, Zhang J, Sun Z, Zhang W, Dong W, Cheng C, Yao Y, Li K
Cell & bioscience 2023 May 13;13(1):87
Cell & bioscience 2023 May 13;13(1):87
PM(2.5) caused ferroptosis in spermatocyte via overloading iron and disrupting redox homeostasis.
Wang J, Zhang Z, Shi F, Li Y, Tang Y, Liu C, Wang Y, Chen J, Jiang X, Yang H, Sun L, Chen Q, Ao L, Han F, Liu J, Cao J
The Science of the total environment 2023 May 10;872:162089
The Science of the total environment 2023 May 10;872:162089
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
Jiang H, Bai Z, Ou Y, Liu H, Si Z, Liu Y, Liu X, Liu X, Zhang Z, Tan N
Journal of ethnopharmacology 2023 May 10;307:116013
Journal of ethnopharmacology 2023 May 10;307:116013
Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization.
Shu N, Zhang Z, Wang X, Li R, Li W, Liu X, Zhang Q, Jiang Z, Tao L, Zhang L, Hou S
Investigative ophthalmology & visual science 2023 May 1;64(5):21
Investigative ophthalmology & visual science 2023 May 1;64(5):21
Ripretinib induced skeletal muscle toxicity through mitochondrial impairment in C2C12 myotubes.
Boran T, Zengin OS, Seker Z, Akyildiz AG, Oztas E, Özhan G
Toxicology 2023 May 1;489:153489
Toxicology 2023 May 1;489:153489
Sivelestat sodium attenuates acute lung injury by inhibiting JNK/NF-κB and activating Nrf2/HO-1 signaling pathways.
Zhang H, Zeng J, Li J, Gong H, Chen M, Li Q, Liu S, Luo S, Dong H, Xu Y, Duan H, Haung L, Lv C
Biomolecules & biomedicine 2023 May 1;23(3):457-470
Biomolecules & biomedicine 2023 May 1;23(3):457-470
Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis.
Zi Y, Wang X, Zi Y, Yu H, Lan Y, Fan Y, Ren C, Liao K, Chen H
Free radical biology & medicine 2023 May 1;200:73-86
Free radical biology & medicine 2023 May 1;200:73-86
The role of ferroptosis mediated by Bmal1/Nrf2 in nicotine -induce injury of BTB integrity.
Zhang Z, Cheng J, Yang L, Li X, Hua R, Xu D, Jiang Z, Li Q
Free radical biology & medicine 2023 May 1;200:26-35
Free radical biology & medicine 2023 May 1;200:26-35
Anti-inflammatory and antioxidative effects of gallic acid on experimental dry eye: in vitro and in vivo studies.
Li K, Gong Q, Lu B, Huang K, Tong Y, Mutsvene TE, Lin M, Xu Z, Lu F, Li X, Hu L
Eye and vision (London, England) 2023 May 1;10(1):17
Eye and vision (London, England) 2023 May 1;10(1):17
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
Liu X, Liu Y, Chen L, Zhang Z, Cui L, Wei T
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
Oral administration of Lactobacillus plantarum JC7 alleviates OVA-induced murine food allergy through immunoregulation and restoring disordered intestinal microbiota.
Duan C, Ma L, Yu J, Sun Y, Liu L, Ma F, Li X, Li D
European journal of nutrition 2023 Mar;62(2):685-698
European journal of nutrition 2023 Mar;62(2):685-698
Is Nrf2 Behind Endogenous Neuroprotection of the Hippocampal CA2-4,DG Region?
Lewczuk A, Zablocka B, Beresewicz-Haller M
Molecular neurobiology 2023 Mar;60(3):1645-1658
Molecular neurobiology 2023 Mar;60(3):1645-1658
Andrographolide-treated bone marrow mesenchymal stem cells-derived conditioned medium protects cardiomyocytes from injury by metabolic remodeling.
Sun Y, Xu H, Tan B, Yi Q, Liu H, Tian J, Zhu J
Molecular biology reports 2023 Mar;50(3):2651-2662
Molecular biology reports 2023 Mar;50(3):2651-2662
Molecular alteration of the proteasome contributes to AD-like pathology in the brain of HFD-STZ diabetic rats.
Gao H, Zhou Y, Jin PS, Wu DG, Wang YN, Zhao X, Zhao B
Metabolic brain disease 2023 Mar;38(3):1013-1024
Metabolic brain disease 2023 Mar;38(3):1013-1024
Ro25-6981 alleviates neuronal damage and improves cognitive deficits by attenuating oxidative stress via the Nrf2/ARE pathway in ischemia/reperfusion rats.
Gao X, Chen F, Xu X, Liu J, Dong F, Liu Y
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Mar;32(3):106971
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Mar;32(3):106971
Abamectin causes cardiac dysfunction in carp via inhibiting redox equilibrium and resulting in immune inflammatory response and programmed cell death.
Zhao P, Wang Y, Yang Q, Yu G, Ma F, Dong J
Environmental science and pollution research international 2023 Mar;30(11):29494-29509
Environmental science and pollution research international 2023 Mar;30(11):29494-29509
Costunolide alleviates hyperglycaemia-induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress.
Jin B, Chen Y, Wang J, Chen Y, Zhang M, Huang J, Wang Y
Journal of cellular and molecular medicine 2023 Mar;27(6):831-845
Journal of cellular and molecular medicine 2023 Mar;27(6):831-845
Protective effects of baicalin against L-glutamate-induced oxidative damage in HT-22 cells by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.
Li J, Wang G, Zhang Y, Fan X, Yao M
Iranian journal of basic medical sciences 2023 Mar;26(3):351-358
Iranian journal of basic medical sciences 2023 Mar;26(3):351-358
LncRNA UCA1 promoted cisplatin resistance in lung adenocarcinoma with HO1 targets NRF2/HO1 pathway.
Shi W, Ling L, Li C, Wu R, Zhang M, Shao F, Wang Y
Journal of cancer research and clinical oncology 2023 Mar;149(3):1295-1311
Journal of cancer research and clinical oncology 2023 Mar;149(3):1295-1311
Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss.
Guo J, Ren R, Guo Z, Sun K, He J, Shao J, Wang X
International immunopharmacology 2023 Mar;116:109820
International immunopharmacology 2023 Mar;116:109820
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Chen L, Mao M, Liu D, Liu W, Wang Y, Xie L, Deng Y, Lin Y, Xu Y, Zhong X, Cao W
International immunopharmacology 2023 Mar;116:109648
International immunopharmacology 2023 Mar;116:109648
Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib.
Yang C, Lu T, Liu M, Yuan X, Li D, Zhang J, Zhou L, Xu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154668
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154668
Uridine Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Ferroptosis of Macrophage.
Lai K, Song C, Gao M, Deng Y, Lu Z, Li N, Geng Q
International journal of molecular sciences 2023 Mar 7;24(6)
International journal of molecular sciences 2023 Mar 7;24(6)
Inhibition of p62 and/or NFE2L2 induced autophagy impaires esophageal squamous cell cancer metastasis by reversing EMT.
Chen X, Yu L, Zhou J, Ren J, Wang S, Tan Y, Ding Y
Gene 2023 Mar 30;858:147194
Gene 2023 Mar 30;858:147194
Antialcohol and Hepatoprotective Effects of Tamarind Shell Extract on Ethanol-Induced Damage to HepG2 Cells and Animal Models.
Han SC, Huang RP, Zhang QY, Yan CY, Li XY, Li YF, He RR, Li WX
Foods (Basel, Switzerland) 2023 Mar 3;12(5)
Foods (Basel, Switzerland) 2023 Mar 3;12(5)
Apigenin improves cytotoxicity of antiretroviral drugs against HTLV-1 infected cells through the modulation of AhR signaling.
Sales D, Lin E, Stoffel V, Dickson S, Khan ZK, Beld J, Jain P
NeuroImmune pharmacology and therapeutics 2023 Mar 25;2(1):49-62
NeuroImmune pharmacology and therapeutics 2023 Mar 25;2(1):49-62
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Cui X, Liu X, Kong P, Du T, Li T, Yang G, Zhang W, Jing X, Wang W
Aging 2023 Mar 24;15(6):2275-2292
Aging 2023 Mar 24;15(6):2275-2292
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
Zhang J, Zhang M, Huo XK, Ning J, Yu ZL, Morisseau C, Sun CP, Hammock BD, Ma XC
ACS central science 2023 Mar 22;9(3):440-456
ACS central science 2023 Mar 22;9(3):440-456
Photobiomodulation Controls Keratinocytes Inflammatory Response through Nrf2 and Reduces Langerhans Cells Activation.
Salman S, Guermonprez C, Peno-Mazzarino L, Lati E, Rousseaud A, Declercq L, Kerdine-Römer S
Antioxidants (Basel, Switzerland) 2023 Mar 21;12(3)
Antioxidants (Basel, Switzerland) 2023 Mar 21;12(3)
Reduced SUMOylation of Nrf2 signaling contributes to its inhibition induced by amyloid-β.
Wang P, Wang X, Qiao K, Zhang Y, Nie Q, Cui J, Sun J, Li L
Neuroscience letters 2023 Mar 16;799:137118
Neuroscience letters 2023 Mar 16;799:137118
Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery.
Wang Y, Cai Z, Zhan G, Li X, Li S, Wang X, Li S, Luo A
Antioxidants (Basel, Switzerland) 2023 Mar 13;12(3)
Antioxidants (Basel, Switzerland) 2023 Mar 13;12(3)
Effects and mechanisms of Xiaochaihu Tang against liver fibrosis: An integration of network pharmacology, molecular docking and experimental validation.
Wang SJ, Ye W, Li WY, Tian W, Zhang M, Sun Y, Feng YD, Liu CX, Liu SY, Cao W, Meng JR, Li XQ
Journal of ethnopharmacology 2023 Mar 1;303:116053
Journal of ethnopharmacology 2023 Mar 1;303:116053
Tingli Dazao Decoction pretreatment ameliorates mitochondrial damage induced by oxidative stress in cardiomyocytes.
Chen H, Zhu Y, Zhao X, Yang Z
Journal of ethnopharmacology 2023 Mar 1;303:115987
Journal of ethnopharmacology 2023 Mar 1;303:115987
Buyang Huanwu decoction alleviates oxidative injury of cerebral ischemia-reperfusion through PKCε/Nrf2 signaling pathway.
Yin M, Liu Z, Wang J, Gao W
Journal of ethnopharmacology 2023 Mar 1;303:115953
Journal of ethnopharmacology 2023 Mar 1;303:115953
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Liu X, Xi H, Han S, Zhang H, Hu J
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Polysaccharide from Flammulina velutipes residues protects mice from Pb poisoning by activating Akt/GSK3β/Nrf-2/HO-1 signaling pathway and modulating gut microbiota.
Liu Y, Li H, Ren P, Che Y, Zhou J, Wang W, Yang Y, Guan L
International journal of biological macromolecules 2023 Mar 1;230:123154
International journal of biological macromolecules 2023 Mar 1;230:123154
Ketogenic diets composed of long-chain and medium-chain fatty acids induce cardiac fibrosis in mice.
Sternberg F, Sternberg C, Dunkel A, Beikbaghban T, Gregor A, Szarzynski A, Somoza V, Walter I, Duszka K, Kofler B, Pohl EE
Molecular metabolism 2023 Jun;72:101711
Molecular metabolism 2023 Jun;72:101711
Farnesol Exerts Protective Effects against Chronic Sleep Deprivation-Induced Cognitive Impairment via Activation SIRT1/Nrf2 Pathway in the Hippocampi of Adult Mice.
Li Y, Xie Z, Luo X, Wang X, Wang Y, Guo M, Zhou Z, Sun R, Hua D, Luo A, Li S
Molecular nutrition & food research 2023 Jun;67(11):e2200735
Molecular nutrition & food research 2023 Jun;67(11):e2200735
UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis.
Gan Y, Deng J, Hao Q, Huang Y, Han T, Xu JG, Zhao M, Yao L, Xu Y, Xiong J, Lu H, Wang C, Chen J, Zhou X
Redox biology 2023 Jun;62:102705
Redox biology 2023 Jun;62:102705
Tubastatin A potently inhibits GPX4 activity to potentiate cancer radiotherapy through boosting ferroptosis.
Liu S, Zhang HL, Li J, Ye ZP, Du T, Li LC, Guo YQ, Yang D, Li ZL, Cao JH, Hu BX, Chen YH, Feng GK, Li ZM, Deng R, Huang JJ, Zhu XF
Redox biology 2023 Jun;62:102677
Redox biology 2023 Jun;62:102677
TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1.
Wei J, Wang L, Zhang Y, Sun T, Zhang C, Hu Z, Zhou L, Liu X, Wan J, Ma L
Oncogene 2023 Jun;42(26):2103-2112
Oncogene 2023 Jun;42(26):2103-2112
Baicalin ameliorates high fat diet-induced nonalcoholic fatty liver disease in mice via adenosine monophosphate-activated protein kinase-mediated regulation of SREBP1/Nrf2/NF-κB signaling pathways.
Gao Y, Liu J, Hao Z, Sun N, Guo J, Zheng X, Sun P, Yin W, Fan K, Li H
Phytotherapy research : PTR 2023 Jun;37(6):2405-2418
Phytotherapy research : PTR 2023 Jun;37(6):2405-2418
Donor graft METTL3 gene transfer ameliorates rat liver transplantation ischemia-reperfusion injury by enhancing HO-1 expression in an m(6)A-dependent manner.
Xiang S, Wang Y, Lei D, Luo Y, Peng D, Zong K, Liu Y, Huang Z, Mo S, Pu X, Zheng J, Wu Z
Clinical immunology (Orlando, Fla.) 2023 Jun;251:109325
Clinical immunology (Orlando, Fla.) 2023 Jun;251:109325
Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair.
Sun H, Xu J, Wang Y, Shen S, Xu X, Zhang L, Jiang Q
Bioactive materials 2023 Jun;24:477-496
Bioactive materials 2023 Jun;24:477-496
Anti-Inflammatory Effects of New Naphthyridine from Sponge Aaptos suberitoides in LPS-Stimulated RAW 264.7 Macrophages via Regulation of MAPK and Nrf2 Signaling Pathways.
Liu M, Zhang Z, He Q, Qi S, Sun K, Miao S, Wu Y, Gong K
Chemistry & biodiversity 2023 Jun;20(6):e202300410
Chemistry & biodiversity 2023 Jun;20(6):e202300410
Schisandrin B Improves the Hypothermic Preservation of Celsior Solution in Human Umbilical Cord Mesenchymal Stem Cells.
Zhang Y, Wang P, Jin MX, Zhou YQ, Ye L, Zhu XJ, Li HF, Zhou M, Li Y, Li S, Liang KY, Wang Y, Gao Y, Pan MX, Zhou SQ, Peng Q
Tissue engineering and regenerative medicine 2023 Jun;20(3):447-459
Tissue engineering and regenerative medicine 2023 Jun;20(3):447-459
Synergistic effects of combined treatment of 1,2-dichloroethane and high-dose ethanol on liver damage in mice and the related mechanisms.
Yang J, Zhang L, Wang T, Zhang J, Li M, Jin X, Tan X, Wang G, Zhao F, Jin Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113812
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113812
Olanzapine-induced nonalcoholic fatty liver disease: The effects of differential food pattern and the involvement of PGRMC1 signaling.
Zhu Z, Cao T, Chen H, Zhang B, Lin C, Cai H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113757
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113757
Anti-oxidative-initiated cognitive impairment amelioration in Alzheimer's disease model rats through preventive transcutaneous electrical acupoint stimulation.
Weng H, Wang Q, Ye R, Bai Y, Yang H, Xu G, Wang Q
Integrative medicine research 2023 Jun;12(2):100946
Integrative medicine research 2023 Jun;12(2):100946
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Yang G, Liu X, Jing X, Wang J, Wang H, Chen F, Wang W, Shao Y, Cui X
International immunopharmacology 2023 Jun;119:110159
International immunopharmacology 2023 Jun;119:110159
Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling.
Wang H, Jia X, Zhang M, Cheng C, Liang X, Wang X, Xie F, Wang J, Yu Y, He Y, Dong Q, Wang Y, Xu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154786
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154786
Wenqingyin suppresses ferroptosis in the pathogenesis of sepsis-induced liver injury by activating the Nrf2-mediated signaling pathway.
Xie L, Zhou C, Wu Y, Fu X, Zhang G, Han X, Xie S, Chen G, Xu H, Deng B, Liu B, Zhou Y, Li A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154748
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154748
PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis.
Wang Z, Li R, Hou N, Zhang J, Wang T, Fan P, Ji C, Zhang B, Liu L, Wang Y, Kong J, Yao Q, Duan J, Zhao G, Ling R, Zhang J
Journal for immunotherapy of cancer 2023 Jun;11(6)
Journal for immunotherapy of cancer 2023 Jun;11(6)
Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure.
Piell KM, Petri BJ, Head KZ, Wahlang B, Xu R, Zhang X, Pan J, Rai SN, de Silva K, Chariker JH, Rouchka EC, Tan M, Li Y, Cave MC, Klinge CM
Environmental toxicology and pharmacology 2023 Jun;100:104138
Environmental toxicology and pharmacology 2023 Jun;100:104138
Ferulic Acid Alleviates Hepatic Lipid Accumulation and Inflammation by Improving Proximal and Distal Intestinal Barriers in NAFLD Mice.
Fu J, Yang J, He L, Yang C, He J, Hua Y, Guo J, Liu S
The Tohoku journal of experimental medicine 2023 Jun 7;260(2):149-163
The Tohoku journal of experimental medicine 2023 Jun 7;260(2):149-163
A copper complex that combats triple negative breast cancer by restraining angiogenesis.
Zheng H, Hu C, Quan Y, Ye X, Shi X, Guo Z, Wang X
Dalton transactions (Cambridge, England : 2003) 2023 Jun 6;52(22):7626-7634
Dalton transactions (Cambridge, England : 2003) 2023 Jun 6;52(22):7626-7634
RETRACTED: Tangzhiqing-mediated NRF2 reduces autophagy-dependent ferroptosis to mitigate diabetes-related cognitive impairment neuronal damage.
Qiu L, Chen K, Wang X, Zhao Y
Rejuvenation research 2023 Jun 6;
Rejuvenation research 2023 Jun 6;
Exercise reduces hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice via its effects against inflammation and oxidative stress.
Pei Z, Ji J, Gao Y, Wang H, Wu Y, Yang J, Yang Q, Zhang L
Scientific reports 2023 Jun 5;13(1):9134
Scientific reports 2023 Jun 5;13(1):9134
Role of ionizing radiation activated NRF2 in lung cancer radioresistance.
Xu Q, Zhang P, Han X, Ren H, Yu W, Hao W, Luo B, Khan MI, Chen N
International journal of biological macromolecules 2023 Jun 30;241:124476
International journal of biological macromolecules 2023 Jun 30;241:124476
Ebselen alleviates white matter lesions and improves cognitive deficits by attenuating oxidative stress via Keap1/Nrf2 pathway in chronic cerebral hypoperfusion mice.
Dong F, Yan W, Meng Q, Song X, Cheng B, Liu Y, Yao R
Behavioural brain research 2023 Jun 25;448:114444
Behavioural brain research 2023 Jun 25;448:114444
Antioxidant Peptides from Monkfish Swim Bladders: Ameliorating NAFLD In Vitro by Suppressing Lipid Accumulation and Oxidative Stress via Regulating AMPK/Nrf2 Pathway.
Wu MF, Xi QH, Sheng Y, Wang YM, Wang WY, Chi CF, Wang B
Marine drugs 2023 Jun 16;21(6)
Marine drugs 2023 Jun 16;21(6)
Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke.
Qiao N, An Z, Fu Z, Chen X, Tong Q, Zhang Y, Ren H
European journal of pharmacology 2023 Jun 15;949:175717
European journal of pharmacology 2023 Jun 15;949:175717
SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway.
Dong L, Xu M, Li Y, Xu W, Wu C, Zheng H, Xiao Z, Sun G, Ding L, Li X, Li W, Zhou L, Xia Q
Cell death & disease 2023 Jun 14;14(6):361
Cell death & disease 2023 Jun 14;14(6):361
Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression.
Feng C, Liu Y, Zhang BY, Zhang H, Shan FY, Li TQ, Zhao ZN, Wang XX, Zhang XY
ACS omega 2023 Jun 13;8(23):20739-20754
ACS omega 2023 Jun 13;8(23):20739-20754
Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer.
Wu W, Zhao Y, Qin B, Jiang X, Wang C, Hu R, Ma R, Lee MH, Liu H, Li K, Yuan P
EBioMedicine 2023 Jul;93:104650
EBioMedicine 2023 Jul;93:104650
CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade.
Li C, Hao J, Qiu H, Xin H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1409-1425
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1409-1425
NFATc1-mediated expression of SLC7A11 drives sensitivity to TXNRD1 inhibitors in osteoclast precursors.
Zhong Z, Zhang C, Ni S, Ma M, Zhang X, Sang W, Lv T, Qian Z, Yi C, Yu B
Redox biology 2023 Jul;63:102711
Redox biology 2023 Jul;63:102711
Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells.
Zou X, Liu C, Huang Z, Xiang S, Li K, Yuan Y, Hao Y, Zhou F
Molecular biology reports 2023 Jul;50(7):5667-5674
Molecular biology reports 2023 Jul;50(7):5667-5674
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
Liang C, Yi K, Zhou X, Li X, Zhong C, Cao H, Xie C, Zhu J
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma.
Wang S, Wang T, Zhang X, Cheng S, Chen C, Yang G, Wang F, Wang R, Zhang Q, Yang D, Zhang Y, Liu S, Qin H, Liu Q, Liu H
Cell death and differentiation 2023 Jul;30(7):1757-1770
Cell death and differentiation 2023 Jul;30(7):1757-1770
Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders.
Pan ZS, Chen YL, Tang KJ, Liu ZZ, Liang JL, Guan YH, Xin XY, Liu CH, Shen CP
Experimental and therapeutic medicine 2023 Jul;26(1):320
Experimental and therapeutic medicine 2023 Jul;26(1):320
Liensinine, a alkaloid from lotus plumule, mitigates lipopolysaccharide-induced sepsis-associated encephalopathy through modulation of nuclear factor erythroid 2-related factor-mediated inflammatory biomarkers and mitochondria apoptosis.
Wang G, Sun Y, Yang Q, Dai D, Zhang L, Fan H, Zhang W, Dong J, Zhao P
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113813
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113813
Resveratrol Promotes Gluconeogenesis by Inhibiting SESN2-mTORC2-AKT Pathway in Calf Hepatocytes.
Wang G, Qin S, Geng H, Zheng Y, Li R, Xia C, Chen L, Yao J, Deng L
The Journal of nutrition 2023 Jul;153(7):1930-1943
The Journal of nutrition 2023 Jul;153(7):1930-1943
Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways.
Idera A, Sharkey LM, Kurauchi Y, Kadoyama K, Paulson HL, Katsuki H, Seki T
Journal of pharmacological sciences 2023 Jul;152(3):182-192
Journal of pharmacological sciences 2023 Jul;152(3):182-192
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Li X, Yu X, He S, Li J
International immunopharmacology 2023 Jul;120:110404
International immunopharmacology 2023 Jul;120:110404
Glycyrrhizin protects against particulate matter-induced lung injury via regulation of endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis through Nrf2/HO-1/NQO1 signaling pathway.
Shi Q, Qian Y, Wang B, Liu L, Chen Y, Chen C, Feng L, Chen J, Dong N
International immunopharmacology 2023 Jul;120:110371
International immunopharmacology 2023 Jul;120:110371
Aloperine alleviates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome activation.
Zeng J, Liu J, Huang JH, Fu SP, Wang XY, Xi C, Cui YR, Qu F
International immunopharmacology 2023 Jul;120:110142
International immunopharmacology 2023 Jul;120:110142
Denervation delays initial bone healing of rat tooth extraction socket.
Sheng Z, Zheng F, Li J, Wang Y, Du Y, Liu X, Yu X
Odontology 2023 Jul;111(3):640-648
Odontology 2023 Jul;111(3):640-648
Transcription Factor Nrf2 Modulates Lipopolysaccharide-Induced Injury in Bovine Endometrial Epithelial Cells.
Song P, Liu C, Sun M, Liu J, Lin P, Chen H, Zhou D, Tang K, Wang A, Jin Y
International journal of molecular sciences 2023 Jul 7;24(13)
International journal of molecular sciences 2023 Jul 7;24(13)
Long noncoding RNA PSMA3-AS1 functions as a competing endogenous RNA to promote gastric cancer progression by regulating the miR-329-3p/ALDOA axis.
Kan L, Yang M, Zhang H
Biology direct 2023 Jul 4;18(1):36
Biology direct 2023 Jul 4;18(1):36
Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury.
Fan K, Chen K, Zan X, Zhi Y, Zhang X, Zhang X, Qiu J, Liu G, Li L, Tang L, Hu K, Wan J, Gong X, Yang Y, Zhang L
Cell death & disease 2023 Jul 31;14(7):486
Cell death & disease 2023 Jul 31;14(7):486
Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice.
Chen F, Zhan J, Al Mamun A, Tao Y, Huang S, Zhao J, Zhang Y, Xu Y, Du S, Lu W, Li X, Chen Z, Xiao J
Food & function 2023 Jul 31;14(15):7176-7194
Food & function 2023 Jul 31;14(15):7176-7194
Ammonium tetrathiomolybdate relieves oxidative stress in cisplatin-induced acute kidney injury via NRF2 signaling pathway.
Qi H, Shi H, Yan M, Zhao L, Yin Y, Tan X, Qi H, Li H, Weng K, Tang Y, Dai Y
Cell death discovery 2023 Jul 25;9(1):259
Cell death discovery 2023 Jul 25;9(1):259
Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways.
Ganapathy AS, Saha K, Wang A, Arumugam P, Dharmaprakash V, Yochum G, Koltun W, Nighot M, Perdew G, Thompson TA, Ma T, Nighot P
Cell reports 2023 Jul 25;42(7):112705
Cell reports 2023 Jul 25;42(7):112705
Baicalin induces ferroptosis in osteosarcomas through a novel Nrf2/xCT/GPX4 regulatory axis.
Wen RJ, Dong X, Zhuang HW, Pang FX, Ding SC, Li N, Mai YX, Zhou ST, Wang JY, Zhang JF
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154881
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154881
The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing.
Li T, Yang C, Cao H, Mo S, Li B, Huang Z, Zhang R, Wu J, Zhang K, Gao Y
Molecules (Basel, Switzerland) 2023 Jul 19;28(14)
Molecules (Basel, Switzerland) 2023 Jul 19;28(14)
Neuroprotective effect of a medium-chain triglyceride ketogenic diet on MPTP-induced Parkinson's disease mice: a combination of transcriptomics and metabolomics in the substantia nigra and fecal microbiome.
Zhang W, Chen S, Huang X, Tong H, Niu H, Lu L
Cell death discovery 2023 Jul 17;9(1):251
Cell death discovery 2023 Jul 17;9(1):251
Protective effect of total flavonoids of Engelhardia roxburghiana Wall. leaves against radiation-induced intestinal injury in mice and its mechanism.
Wu S, Tian C, Tu Z, Guo J, Xu F, Qin W, Chang H, Wang Z, Hu T, Sun X, Ning H, Li Y, Gou W, Hou W
Journal of ethnopharmacology 2023 Jul 15;311:116428
Journal of ethnopharmacology 2023 Jul 15;311:116428
Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro.
Zhu Y, Han Y, Wang W, Liang G, Qi J
Journal of ethnopharmacology 2023 Jul 15;311:116286
Journal of ethnopharmacology 2023 Jul 15;311:116286
Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1.
Qi M, Zhong H, Cheng Z, Chen S, Xiao H, Shang J, Chen L, Sun J
Journal of medicinal chemistry 2023 Jul 13;66(13):9184-9200
Journal of medicinal chemistry 2023 Jul 13;66(13):9184-9200
Tripterygium glycosides reverse chemotherapy resistance in ovarian cancer by targeting the NRF2/GPX4 signal axis to induce ferroptosis of drug-resistant human epithelial ovarian cancer cells.
Ma B, Zhong Y, Chen R, Zhan X, Huang G, Xiong Y, Tan B
Biochemical and biophysical research communications 2023 Jul 12;665:178-186
Biochemical and biophysical research communications 2023 Jul 12;665:178-186
Gomphrena globosa L. extract alleviates carbon tetrachoride-induced liver injury in mice by activating antioxidant signaling pathways and promoting autophagy.
Wei Y, Tan W, Qin H, Jin M, Yu H, Cheng J, Feng H
Molecular biology reports 2023 Jan;50(1):97-106
Molecular biology reports 2023 Jan;50(1):97-106
Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway.
Xiao S, Zhou Y, Gao H, Yang D
Molecular medicine reports 2023 Jan;27(1)
Molecular medicine reports 2023 Jan;27(1)
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Li M, Zhang Y, Han T, Guan L, Fan D, Wu Q, Liu J, Xu Y, Fan Y
Phytochemistry 2023 Jan;205:113487
Phytochemistry 2023 Jan;205:113487
Diterpenoids with anti-inflammatory activity from Euphorbia wallichii.
Wang Y, Sun D, Jiang Q, Xiong L, Zhang N, Pan Y, Li H, Chen L
Phytochemistry 2023 Jan;205:113486
Phytochemistry 2023 Jan;205:113486
A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis.
Fan J, Xu X, Li Y, Zhang L, Miao M, Niu Y, Zhang Y, Zhang A, Jia Z, Wu M
Free radical biology & medicine 2023 Jan;194:84-98
Free radical biology & medicine 2023 Jan;194:84-98
TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K/Akt/Nrf2/Ferritin H pathway.
Cheng Y, Gao Y, Li J, Rui T, Li Q, Chen H, Jia B, Song Y, Gu Z, Wang T, Gao C, Wang Y, Wang Z, Wang F, Tao L, Luo C
Free radical biology & medicine 2023 Jan;194:184-198
Free radical biology & medicine 2023 Jan;194:184-198
Pine pollen extract alleviates ethanol-induced oxidative stress and apoptosis in HepG2 cells via MAPK signaling.
Ma D, Wang Z, He Z, Wang Z, Chen Q, Qin F, Zeng M, Chen J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113550
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113550
Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.
Mi Y, Wei C, Sun L, Liu H, Zhang J, Luo J, Yu X, He J, Ge H, Liu P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:114048
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:114048
Pterostilbene alleviated NAFLD via AMPK/mTOR signaling pathways and autophagy by promoting Nrf2.
Shen B, Wang Y, Cheng J, Peng Y, Zhang Q, Li Z, Zhao L, Deng X, Feng H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154561
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154561
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
Zheng M, Hu Z, Wang Y, Wang C, Zhong C, Cui W, You J, Gao B, Sun X, La L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
Nrf2 attenuates methamphetamine-induced myocardial injury by regulating oxidative stress and apoptosis in mice.
Yu H, Peng Y, Dong W, Shen B, Yang G, Nie Q, Tian Y, Qin L, Song C, Chen B, Zhao Y, Li L, Hong S
Human & experimental toxicology 2023 Jan-Dec;42:9603271231219488
Human & experimental toxicology 2023 Jan-Dec;42:9603271231219488
Effects of NBP on postoperative cognitive dysfunction in rats via Nrf 2/ARE pathway.
He J, Gao J, Zhu H, Zhao Y, Zhang X, Wang X, Wan S, Cao H, Zhai L, Wang Y, Wang S
Aging 2023 Jan 9;15(1):276-286
Aging 2023 Jan 9;15(1):276-286
Therapeutic Hypothermia after Cardiac Arrest Attenuates Hindlimb Paralysis and Damage of Spinal Motor Neurons and Astrocytes through Modulating Nrf2/HO-1 Signaling Pathway in Rats.
Ahn JH, Lee TK, Kim DW, Shin MC, Cho JH, Lee JC, Tae HJ, Park JH, Hong S, Lee CH, Won MH, Kim YH
Cells 2023 Jan 26;12(3)
Cells 2023 Jan 26;12(3)
Bifidobacterium animalis A12 and Lactobacillus salivarius M18-6 Alleviate Alcohol Injury by keap1-Nrf2 Pathway and Thioredoxin System.
Zhang Y, Ma J, Jing N, Zhang H, Xie Y, Liu H, Shan X, Ren J, Jin J
Foods (Basel, Switzerland) 2023 Jan 17;12(3)
Foods (Basel, Switzerland) 2023 Jan 17;12(3)
Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway.
Wu Y, Wu Y, Yu J, Zhang Y, Li Y, Fu R, Sun Y, Zhao K, Xiao Q
European journal of pharmacology 2023 Jan 15;939:175476
European journal of pharmacology 2023 Jan 15;939:175476
Evaluation of toxicological effects of bisphenol S with an in vitro human bone marrow mesenchymal stem cell: Implications for bone health.
Li M, Li T, Yin J, Xie C, Zhu J
Toxicology 2023 Jan 15;484:153408
Toxicology 2023 Jan 15;484:153408
CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
Yu X, Tong H, Chen J, Tang C, Wang S, Si Y, Wang S, Tang Z
Cell death & disease 2023 Jan 12;14(1):20
Cell death & disease 2023 Jan 12;14(1):20
Fresh Medium or L-Cystine as an Effective Nrf2 Inducer for Cytoprotection in Cell Culture.
Dai W, Chen QM
Cells 2023 Jan 12;12(2)
Cells 2023 Jan 12;12(2)
Drug repurposing of ilepcimide that ameliorates experimental autoimmune encephalomyelitis via restricting inflammatory response and oxidative stress.
Xu Z, Lu S, Liu X, Tang L, Liu Z, Cui J, Wang W, Lu W, Huang J
Toxicology and applied pharmacology 2023 Jan 1;458:116328
Toxicology and applied pharmacology 2023 Jan 1;458:116328
Hydrogen sulfide protects retinal pigment epithelium cells against ferroptosis through the AMPK- and p62-dependent non-canonical NRF2-KEAP1 pathway.
Yu M, Wang W, Dang J, Liu B, Xu J, Li J, Liu Y, He L, Ying Y, Cai J, Cheng G, Liu K
Experimental cell research 2023 Jan 1;422(1):113436
Experimental cell research 2023 Jan 1;422(1):113436
Organic extracts in PM2.5 are the major triggers to induce ferroptosis in SH-SY5Y cells.
Guo C, Lyu Y, Xia S, Ren X, Li Z, Tian F, Zheng J
Ecotoxicology and environmental safety 2023 Jan 1;249:114350
Ecotoxicology and environmental safety 2023 Jan 1;249:114350
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114
Theriogenology 2023 Jan 1;195:103-114
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
Yang J, Han F, Wu G, Dong Y, Su H, Xu J, Li J
Digestive diseases and sciences 2023 Feb;68(2):478-486
Digestive diseases and sciences 2023 Feb;68(2):478-486
Melatonin Alleviates the Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway.
Zheng Y, Gao N, Zhang W, Ma R, Chi F, Gao Z, Cong N
Molecular neurobiology 2023 Feb;60(2):629-642
Molecular neurobiology 2023 Feb;60(2):629-642
Dual Antioxidant DH-217 Mitigated Cerebral Ischemia-Reperfusion Injury by Targeting IKKβ/Nrf2/HO-1 Signal Axis.
Shen M, Zheng Y, Li G, Chen Y, Huang L, Wu J, Hong C
Neurochemical research 2023 Feb;48(2):579-590
Neurochemical research 2023 Feb;48(2):579-590
Corynoline ameliorates dextran sulfate sodium-induced colitis in mice by modulating Nrf2/NF-κB pathway.
Zhang H, Lang W, Li S, Xu C, Wang X, Li Y, Zhang Z, Wu T, Feng M
Immunopharmacology and immunotoxicology 2023 Feb;45(1):26-34
Immunopharmacology and immunotoxicology 2023 Feb;45(1):26-34
Curcumin alleviates ketamine-induced oxidative stress and apoptosis via Nrf2 signaling pathway in rats' cerebral cortex and hippocampus.
Zhang X, Cui Y, Song X, Jin X, Sheng X, Xu X, Li T, Chen H, Gao L
Environmental toxicology 2023 Feb;38(2):300-311
Environmental toxicology 2023 Feb;38(2):300-311
TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy.
Zhang X, Li S, Ren X, Xiang P, Zhang Y, Wang T, Qin Q, Sun F, Liu J, Gao L, Ma C, Yue X, Yang X, Han S, Liang X
The FEBS journal 2023 Feb;290(4):1117-1133
The FEBS journal 2023 Feb;290(4):1117-1133
Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors.
Liang X, Wei Y, Hou X, Guo Q, Liang H, Zeng K, Tu P, Zhang Q
Phytochemistry 2023 Feb;206:113530
Phytochemistry 2023 Feb;206:113530
Dietary curcumin supplementation relieves hydrogen peroxide-induced testicular injury by antioxidant and anti-apoptotic effects in roosters.
Wu H, Ye N, Huang Z, Lei K, Shi F, Wei Q
Theriogenology 2023 Feb;197:46-56
Theriogenology 2023 Feb;197:46-56
Protective effect of human umbilical cord mesenchymal stem cell derived conditioned medium in a mutant TDP-43 induced motoneuron-like cellular model of ALS.
Lan J, Zhou Y, Wang H, Tang J, Kang Y, Wang P, Liu X, Peng Y
Brain research bulletin 2023 Feb;193:106-116
Brain research bulletin 2023 Feb;193:106-116
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512
Materials today. Bio 2023 Feb;18:100512
Chemical constituents from the stems and leaves of Amomum villosum Lour. and their anti-inflammatory and antioxidant activities.
Gao C, Zhu M, Xu W, Wang Y, Xiong L, Sun D, Sun M, Lin Y, Li H, Chen L
Bioorganic chemistry 2023 Feb;131:106281
Bioorganic chemistry 2023 Feb;131:106281
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
Zhou Y, Tang J, Lan J, Zhang Y, Wang H, Chen Q, Kang Y, Sun Y, Feng X, Wu L, Jin H, Chen S, Peng Y
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis.
Zhu D, Kong M, Chen C, Luo J, Kong L
International immunopharmacology 2023 Feb;115:109689
International immunopharmacology 2023 Feb;115:109689
Cold exposure induces browning of bovine subcutaneous white fat in vivo and in vitro.
Li T, Bai H, Yang L, Wang H, Wei S, Yan P
Journal of thermal biology 2023 Feb;112:103446
Journal of thermal biology 2023 Feb;112:103446
Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly.
Gong MJ, Zhang HB, Lou M, Wang YS, Ma RP, Hu ZZ, Zheng GX, Zhang Y
Immunity, inflammation and disease 2023 Feb;11(2):e788
Immunity, inflammation and disease 2023 Feb;11(2):e788
Active Nrf2 signaling flexibly regulates HO-1 and NQO-1 in hypoxic Gansu Zokor (Eospalax cansus).
Li M, Peng Y, Chen W, Gao Y, Yang M, Li J, He J
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110811
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110811
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways.
Zhang M, Zhang J, Zhu QM, Zhao WY, Lv X, Yi J, Huo XK, Wang MJ, Sun CP
The Journal of pharmacy and pharmacology 2023 Feb 8;75(2):287-299
The Journal of pharmacy and pharmacology 2023 Feb 8;75(2):287-299
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
Chen Y, Liu X, Li L, He X, Zheng F, Zhang Y, Gao H, Jin Z, Wu D, Wang Q, Tao H, Zhao Y, Liu W, Zou L
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19
Secretome of hESC-Derived MSC-like Immune and Matrix Regulatory Cells Mitigate Pulmonary Fibrosis through Antioxidant and Anti-Inflammatory Effects.
Hu W, Yang J, Xue J, Ma J, Wu S, Wang J, Xu R, Wei J, Wang Y, Wang S, Liu X
Biomedicines 2023 Feb 5;11(2)
Biomedicines 2023 Feb 5;11(2)
NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress.
Wang Y, Zan Y, Huang Y, Peng X, Ma S, Ren J, Li X, Wei L, Wang X, Yuan Y, Tang J, Zhan Z, Wang Z, Ding Y
Cell death discovery 2023 Feb 4;9(1):43
Cell death discovery 2023 Feb 4;9(1):43
Cytotoxic and Antioxidant Activity of Hypericum perforatum L. Extracts against Human Melanoma Cells from Different Stages of Cancer Progression, Cultured under Normoxia and Hypoxia.
Brankiewicz A, Trzos S, Mrożek M, Opydo M, Szostak E, Dziurka M, Tuleja M, Łoboda A, Pocheć E
Molecules (Basel, Switzerland) 2023 Feb 3;28(3)
Molecules (Basel, Switzerland) 2023 Feb 3;28(3)
Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis.
Xu XQ, Xu T, Ji W, Wang C, Ren Y, Xiong X, Zhou X, Lin SH, Xu Y, Qiu Y
mBio 2023 Feb 28;14(1):e0237022
mBio 2023 Feb 28;14(1):e0237022
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke.
Zheng H, Guo X, Kang S, Li Z, Tian T, Li J, Wang F, Yu P, Chang S, Chang YZ
Cell death & disease 2023 Feb 25;14(2):161
Cell death & disease 2023 Feb 25;14(2):161
Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation.
Li H, Weng Q, Gong S, Zhang W, Wang J, Huang Y, Li Y, Guo J, Lan T
Food & function 2023 Feb 21;14(4):1884-1896
Food & function 2023 Feb 21;14(4):1884-1896
Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy.
Xia Q, Li Y, Xu W, Wu C, Zheng H, Liu L, Dong L
Cell & bioscience 2023 Feb 21;13(1):37
Cell & bioscience 2023 Feb 21;13(1):37
Elabela-APJ axis attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal ferroptosis.
Xu P, Kong L, Tao C, Zhu Y, Cheng J, Li W, Shen N, Li R, Zhang C, Wang L, Zhang Y, Wang G, Liu X, Sun W, Hu W
Free radical biology & medicine 2023 Feb 20;196:171-186
Free radical biology & medicine 2023 Feb 20;196:171-186
Ferroptosis Inducers Kill Mesenchymal Stem Cells Affected by Neuroblastoma.
Li X, Wang Q, Xu C, Zhang L, Zhou J, Lv J, Xu M, Jiang D
Cancers 2023 Feb 18;15(4)
Cancers 2023 Feb 18;15(4)
Nanodrug rescues liver fibrosis via synergistic therapy with H(2)O(2) depletion and Saikosaponin b1 sustained release.
Dong H, Han X, Hao M, Yang Q, Lyu Q, Tang D, Shen Z, Wang K, Kuang H, Cao G, Peng M, Shao M
Communications biology 2023 Feb 16;6(1):184
Communications biology 2023 Feb 16;6(1):184
Piperlongumine conjugates induce targeted protein degradation.
Pei J, Xiao Y, Liu X, Hu W, Sobh A, Yuan Y, Zhou S, Hua N, Mackintosh SG, Zhang X, Basso KB, Kamat M, Yang Q, Licht JD, Zheng G, Zhou D, Lv D
Cell chemical biology 2023 Feb 16;30(2):203-213.e17
Cell chemical biology 2023 Feb 16;30(2):203-213.e17
RTA dh404 Induces Cell Cycle Arrest, Apoptosis, and Autophagy in Glioblastoma Cells.
Tsai TH, Su YF, Tsai CY, Wu CH, Lee KT, Hsu YC
International journal of molecular sciences 2023 Feb 16;24(4)
International journal of molecular sciences 2023 Feb 16;24(4)
Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3/ATF3/SLC7A11 signaling.
Zhu B, Ni Y, Gong Y, Kang X, Guo H, Liu X, Li J, Wang L
Life sciences 2023 Feb 15;315:121331
Life sciences 2023 Feb 15;315:121331
β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells.
Zhang Y, Mao H, Li Y, Xiong Y, Liu X, Wang L, Chen Z
International journal of molecular sciences 2023 Feb 14;24(4)
International journal of molecular sciences 2023 Feb 14;24(4)
Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis.
Fei Q, Liu J, Qiao L, Zhang M, Xia H, Lu D, Wu D, Wang J, Li R, Li J, Yang F, Liu D, Xie B, Hui W, Qian B
Biochemical and biophysical research communications 2023 Feb 12;644:140-148
Biochemical and biophysical research communications 2023 Feb 12;644:140-148
Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages.
Yabaji SM, Rukhlenko OS, Chatterjee S, Bhattacharya B, Wood E, Kasaikina M, Kholodenko B, Gimelbrant AA, Kramnik I
bioRxiv : the preprint server for biology 2023 Feb 10;
bioRxiv : the preprint server for biology 2023 Feb 10;
Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK/NRF2 pathway.
Lu Q, Yang L, Xiao JJ, Liu Q, Ni L, Hu JW, Yu H, Wu X, Zhang BF
Free radical biology & medicine 2023 Feb 1;195:89-102
Free radical biology & medicine 2023 Feb 1;195:89-102
Anesthetic propofol inhibits ferroptosis and aggravates distant cancer metastasis via Nrf2 upregulation.
Zhang B, Hou Q, Zhang X, Ma Y, Yuan J, Li S, Zhao X, Sun L, Wang H, Zheng H
Free radical biology & medicine 2023 Feb 1;195:298-308
Free radical biology & medicine 2023 Feb 1;195:298-308
17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation.
Yang R, Li J, Zhang J, Xue Q, Qin R, Wang R, Goltzman D, Miao D
Free radical biology & medicine 2023 Feb 1;195:231-244
Free radical biology & medicine 2023 Feb 1;195:231-244
Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway.
Song G, Wang J, Liu J, Ruan Y
Redox biology 2023 Dec;68:102938
Redox biology 2023 Dec;68:102938
Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway.
Ding J, Lu B, Liu L, Zhong Z, Wang N, Li B, Sheng W, He Q
Pharmaceutical biology 2023 Dec;61(1):213-227
Pharmaceutical biology 2023 Dec;61(1):213-227
Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress.
Liu Q, Duan SB, Wang L, Luo XQ, Wang HS, Deng YH, Wu X, Wu T, Yan And P, Kang YX
Renal failure 2023 Dec;45(1):2179852
Renal failure 2023 Dec;45(1):2179852
Sulforaphane attenuates irradiation induced testis injury in mice.
Ran Y, Duan N, Gao Z, Liu Y, Liu X, Xue B
Redox report : communications in free radical research 2023 Dec;28(1):2279818
Redox report : communications in free radical research 2023 Dec;28(1):2279818
Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway.
Huang J, Zhu Y, Li S, Jiang H, Chen N, Xiao H, Liu J, Liang D, Zheng Q, Tang J, Meng X
Redox report : communications in free radical research 2023 Dec;28(1):2243423
Redox report : communications in free radical research 2023 Dec;28(1):2243423
Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats.
Hu B, Tian T, Li XT, Hao PP, Liu WC, Chen YG, Jiang TY, Chen PS, Cheng Y, Xue FS
Redox report : communications in free radical research 2023 Dec;28(1):2158526
Redox report : communications in free radical research 2023 Dec;28(1):2158526
Park7 protects retinal ganglion cells and promotes functional preservation after optic nerve crush via regulation of the Nrf2 signaling pathway.
Ouyang L, He T, Xing Y
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2023 Dec;261(12):3489-3502
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2023 Dec;261(12):3489-3502
Torachrysone-8-O-β-d-glucoside mediates anti-inflammatory effects by blocking aldose reductase-catalyzed metabolism of lipid peroxidation products.
Zhao WL, Xu D, Wang JS
Biochemical pharmacology 2023 Dec;218:115931
Biochemical pharmacology 2023 Dec;218:115931
Tussilagone inhibits osteoclastogenesis by modulating mitochondrial function and ROS production involved Nrf2 activation.
Feng X, Liu Z, Su Y, Lian H, Gao Y, Zhao J, Xu J, Liu Q, Song F
Biochemical pharmacology 2023 Dec;218:115895
Biochemical pharmacology 2023 Dec;218:115895
Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2.
Wang H, Yang G, Zhang X, Zhang H, Liu Y, Wang C, Miao L, Li Y, Huang Y, Teng H, Wang S, Cheng H, Zeng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114196
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114196
ZnO nanoparticles impair autophagic flux and cell viability through the TRIM16-NRF2-p62 pathway in inflammatory keratinocytes.
Wang M, Zheng H, Chen J, Tang Y, Feng M, Li L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114177
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114177
Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signalling.
Sun J, Wang XH, Song FH, Li DY, Gao SJ, Zhang LQ, Wu JY, Liu DQ, Wang LW, Zhou YQ, Mei W
British journal of pharmacology 2023 Dec;180(24):3194-3214
British journal of pharmacology 2023 Dec;180(24):3194-3214
Upregulation of autotaxin by oxidative stress via Nrf2 activation: A novel insight into the compensation mechanism in preeclamptic placenta.
Yanagisawa M, Nagamatsu T, Kurano M, Misumi F, Taguchi A, Akiba N, Ichinose M, Kumasawa K, Iriyama T, Fujii T, Yatomi Y, Osuga Y
Journal of reproductive immunology 2023 Dec;160:104153
Journal of reproductive immunology 2023 Dec;160:104153
Eicosapentaenoic acid enhances the sensitivity of osteosarcoma to cisplatin by inducing ferroptosis through the DNA-PKcs/AKT/NRF2 pathway and reducing PD-L1 expression to attenuate immune evasion.
Zhang Y, Shen G, Meng T, Lv Z, Li X, Li J, Li K
International immunopharmacology 2023 Dec;125(Pt B):111181
International immunopharmacology 2023 Dec;125(Pt B):111181
Umbelliferone attenuates cisplatin-induced acute kidney injury by inhibiting oxidative stress and inflammation via NRF2.
Yang Z, Ning R, Liu Q, Zang R, Liu S, Sun S
Physiological reports 2023 Dec;11(23):e15879
Physiological reports 2023 Dec;11(23):e15879
Hyperacute autonomic and cortical function recovery following cardiac arrest resuscitation in a rodent model.
Guo Y, Gharibani P, Agarwal P, Cho SM, Thakor NV, Geocadin RG
Annals of clinical and translational neurology 2023 Dec;10(12):2223-2237
Annals of clinical and translational neurology 2023 Dec;10(12):2223-2237
Oat Peptides Alleviate Dextran Sulfate Sodium Salt-Induced Colitis by Maintaining the Intestinal Barrier and Modulating the Keap1-Nrf2 Axis.
Ji ZH, Xie WY, Zhao PS, Wu HY, Ren WZ, Hu JP, Gao W, Yuan B
Nutrients 2023 Dec 9;15(24)
Nutrients 2023 Dec 9;15(24)
The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.
Zou L, Huang J, Zhang Q, Mo H, Xia W, Zhu C, Rao M
Human reproduction (Oxford, England) 2023 Dec 4;38(12):2422-2432
Human reproduction (Oxford, England) 2023 Dec 4;38(12):2422-2432
Klotho activation of Nrf2 inhibits the ferroptosis signaling pathway to ameliorate sepsis-associated acute kidney injury.
Zhou P, Zhao C, Chen Y, Liu X, Wu C, Hu Z
Translational andrology and urology 2023 Dec 31;12(12):1871-1884
Translational andrology and urology 2023 Dec 31;12(12):1871-1884
Dietary pyrroloquinoline quinone improvement of the antioxidant capacity of laying hens and eggs are linked to the alteration of Nrf2/HO-1 pathway and gut microbiota.
Shao D, Liu L, Tong H, Shi S
Food chemistry: X 2023 Dec 30;20:101021
Food chemistry: X 2023 Dec 30;20:101021
Novel Antioxidant Peptides Derived from Feather Keratin Alleviate H(2)O(2)-Induced Oxidative Damage in HepG2 Cells via Keap1/Nrf2 Pathway.
Pei XD, He YN, Wu QL, Zhang YM, Li F, Jiao DQ, Liu XL, Wang CH
Journal of agricultural and food chemistry 2023 Dec 20;71(50):20062-20072
Journal of agricultural and food chemistry 2023 Dec 20;71(50):20062-20072
DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
Chang K, Chen Y, Zhang X, Zhang W, Xu N, Zeng B, Wang Y, Feng T, Dai B, Xu F, Ye D, Wang C
Cancer research 2023 Dec 1;83(23):3940-3955
Cancer research 2023 Dec 1;83(23):3940-3955
Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways.
Zhou Q, Zhou Q, Xia R, Zhang P, Xie Y, Yang Z, Khan A, Zhou Z, Tan W, Liu L
Heliyon 2023 Aug;9(8):e18746
Heliyon 2023 Aug;9(8):e18746
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
Chen H, Ma Y, Qi X, Tian J, Ma Y, Niu T
Molecular nutrition & food research 2023 Aug;67(16):e2200499
Molecular nutrition & food research 2023 Aug;67(16):e2200499
Development of KEAP1-targeting PROTAC and its antioxidant properties: In vitro and in vivo.
Park SY, Gurung R, Hwang JH, Kang JH, Jung HJ, Zeb A, Hwang JI, Park SJ, Maeng HJ, Shin D, Oh SH
Redox biology 2023 Aug;64:102783
Redox biology 2023 Aug;64:102783
CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma.
Wu N, Zhu D, Li J, Li X, Zhu Z, Rao Q, Hu B, Wang H, Zhu Y
Journal of endocrinological investigation 2023 Aug;46(8):1573-1587
Journal of endocrinological investigation 2023 Aug;46(8):1573-1587
Inhibition of SIRT1 promotes ultraviolet B induced cataract via downregulation of the KEAP1/NFE2L2 signaling pathway.
Wu F, Xia X, Lei T, Du H, Hua H, Liu W, Xu B, Yang T
Journal of photochemistry and photobiology. B, Biology 2023 Aug;245:112753
Journal of photochemistry and photobiology. B, Biology 2023 Aug;245:112753
miR-1273h-5p protects the human corneal epithelium against UVR-induced oxidative stress and apoptosis: Role of miR-1273h-5p in climatic droplet keratopathy.
Hua Z, Shi R, Han X, Li G, Lv L, Jianimuhan N, Ma D, Cai L, Hu F, Yang J
Experimental eye research 2023 Aug;233:109536
Experimental eye research 2023 Aug;233:109536
ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
Yang M, Chen Y, Huang X, Shen F, Meng Y
Lung 2023 Aug;201(4):425-441
Lung 2023 Aug;201(4):425-441
NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1(G93A) mutation and exerts neuroprotection in amyotrophic lateral sclerosis.
Yang B, Pan J, Zhang XN, Wang H, He L, Rong X, Li X, Peng Y
Neurobiology of disease 2023 Aug;184:106210
Neurobiology of disease 2023 Aug;184:106210
Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.
Liu Z, Nan P, Gong Y, Tian L, Zheng Y, Wu Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114897
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114897
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Wan D, Zhu Z, Zhou J, Deng Z, Lei P, Liu Q, Sun X, Huang B
Toxicology research 2023 Aug;12(4):635-647
Toxicology research 2023 Aug;12(4):635-647
Oxazole-4-carboxamide/butylated hydroxytoluene hybrids with GSK-3β inhibitory and neuroprotective activities against Alzheimer's disease.
Luo Z, Li S, Zhang Y, Yin F, Luo H, Chen X, Cui N, Wan S, Li X, Kong L, Wang X
European journal of medicinal chemistry 2023 Aug 5;256:115415
European journal of medicinal chemistry 2023 Aug 5;256:115415
High-Frequency Repetitive Magnetic Stimulation Activates Bactericidal Activity of Macrophages via Modulation of p62/Keap1/Nrf2 and p38 MAPK Pathways.
Deramaudt TB, Chehaitly A, Charrière T, Arnaud J, Bonay M
Antioxidants (Basel, Switzerland) 2023 Aug 30;12(9)
Antioxidants (Basel, Switzerland) 2023 Aug 30;12(9)
Metabolomic Analysis of Trehalose Alleviating Oxidative Stress in Myoblasts.
Zhang S, Qiu X, Zhang Y, Huang C, Lin D
International journal of molecular sciences 2023 Aug 28;24(17)
International journal of molecular sciences 2023 Aug 28;24(17)
Sarmentosin Induces Autophagy-dependent Apoptosis via Activation of Nrf2 in Hepatocellular Carcinoma.
Jiang Z, Gao L, Liu C, Wang J, Han Y, Pan J
Journal of clinical and translational hepatology 2023 Aug 28;11(4):863-876
Journal of clinical and translational hepatology 2023 Aug 28;11(4):863-876
FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner.
Kim JW, Kim MJ, Han TH, Lee JY, Kim S, Kim H, Oh KJ, Kim WK, Han BS, Bae KH, Ban HS, Bae SH, Lee SC, Lee H, Lee EW
Cell death & disease 2023 Aug 26;14(8):567
Cell death & disease 2023 Aug 26;14(8):567
Liquiritigenin Confers Liver Protection by Enhancing NRF2 Signaling through Both Canonical and Non-canonical Signaling Pathways.
Shi M, Zhang J, Li M, Zhao Y, Guo Y, Xu J, Liu R, Li Z, Ren D, Liu P
Journal of medicinal chemistry 2023 Aug 24;66(16):11324-11334
Journal of medicinal chemistry 2023 Aug 24;66(16):11324-11334
Effects of Different Dietary Zinc (Zn) Sources on Growth Performance, Zn Metabolism, and Intestinal Health of Grass Carp.
Xu YC, Zheng H, Guo JC, Tan XY, Zhao T, Song YF, Wei XL, Luo Z
Antioxidants (Basel, Switzerland) 2023 Aug 23;12(9)
Antioxidants (Basel, Switzerland) 2023 Aug 23;12(9)
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
Li L, Guo C, Yu Y, Tie L, Lu G, Liu F, Han X, Ji L, Zou X
Cell & bioscience 2023 Aug 21;13(1):154
Cell & bioscience 2023 Aug 21;13(1):154
Retinoic acid protects against lipopolysaccharide-induced ferroptotic liver injury and iron disorders by regulating Nrf2/HO-1 and RARβ signaling.
Lai X, Wu A, Bing Y, Liu Y, Luo J, Yan H, Zheng P, Yu J, Chen D
Free radical biology & medicine 2023 Aug 20;205:202-213
Free radical biology & medicine 2023 Aug 20;205:202-213
B7-H3 confers stemness characteristics to gastric cancer cells by promoting glutathione metabolism through AKT/pAKT/Nrf2 pathway.
Xia L, Chen Y, Li J, Wang J, Shen K, Zhao A, Jin H, Zhang G, Xi Q, Xia S, Shi T, Li R
Chinese medical journal 2023 Aug 20;136(16):1977-1989
Chinese medical journal 2023 Aug 20;136(16):1977-1989
Neuroprotective Effects of Activin A against Cerebral Ischemia/Reperfusion Injury in Mice by Enhancing Nrf2 Expression to Attenuate Neuronal Ferroptosis.
Wang F, Ma M, Yang J, Shi X, Wang J, Xu Z
ACS chemical neuroscience 2023 Aug 2;14(15):2818-2826
ACS chemical neuroscience 2023 Aug 2;14(15):2818-2826
The mitochondrial-derived peptide MOTS-c suppresses ferroptosis and alleviates acute lung injury induced by myocardial ischemia reperfusion via PPARγ signaling pathway.
Lu P, Li X, Li B, Li X, Wang C, Liu Z, Ji Y, Wang X, Wen Z, Fan J, Yi C, Song M, Wang X
European journal of pharmacology 2023 Aug 15;953:175835
European journal of pharmacology 2023 Aug 15;953:175835
linc01515 regulates PM(2.5)-induced oxidative stress via targeting NRF2 in airway epithelial cells.
Wang X, Zhu H, Sun G, Zhou M, Zhang H, Liu H, Wang M, Zhang Z, Chu H
Environmental pollution (Barking, Essex : 1987) 2023 Aug 15;331(Pt 2):121798
Environmental pollution (Barking, Essex : 1987) 2023 Aug 15;331(Pt 2):121798
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Gao Z, Zhan H, Zong W, Sun M, Linghu L, Wang G, Meng F, Chen M
Life sciences 2023 Aug 15;327:121793
Life sciences 2023 Aug 15;327:121793
Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity.
Xiao X, Hu H, Zhong Y, Chen Y, Tang K, Pan Z, Huang J, Yang X, Wang Q, Gao Y
Molecular medicine (Cambridge, Mass.) 2023 Aug 15;29(1):108
Molecular medicine (Cambridge, Mass.) 2023 Aug 15;29(1):108
Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota.
Huang W, Chen H, He Q, Xie W, Peng Z, Ma Q, Huang Q, Chen Z, Liu Y
Food & function 2023 Aug 14;14(16):7692-7704
Food & function 2023 Aug 14;14(16):7692-7704
Exosomes secreted by mesenchymal stem cells delay brain aging by upregulating SIRT1 expression.
Zhang X, Liu T, Hou X, Zhou Z, Zhang F, Ma H, Wu X, Jiang J
Scientific reports 2023 Aug 14;13(1):13213
Scientific reports 2023 Aug 14;13(1):13213
Correction: Tang et al. Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop. Nutrients 2022, 14, 1504.
Tang H, Zheng Z, Wang H, Wang L, Zhao G, Wang P
Nutrients 2023 Aug 11;15(16)
Nutrients 2023 Aug 11;15(16)
TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling.
Xu T, Yang Y, Chen Z, Wang J, Wang X, Zheng Y, Wang C, Wang Y, Zhu Z, Ding X, Zhou J, Li G, Zhang H, Zhang W, Wu Y, Song X
Journal of experimental & clinical cancer research : CR 2023 Aug 1;42(1):190
Journal of experimental & clinical cancer research : CR 2023 Aug 1;42(1):190
Nrf2 protects against methamphetamine-induced nephrotoxicity by mitigating oxidative stress and autophagy in mice.
Dong W, Wan J, Yu H, Shen B, Yang G, Nie Q, Tian Y, Qin L, Song C, Chen B, Li L, Hong S
Toxicology letters 2023 Aug 1;384:136-148
Toxicology letters 2023 Aug 1;384:136-148
Ginsenoside Rg1 protects cardiac mitochondrial function via targeting GSTP1 to block S-glutathionylation of optic atrophy 1.
Zhu H, Yan C, Yao P, Li P, Li Y, Yang H
Free radical biology & medicine 2023 Aug 1;204:54-67
Free radical biology & medicine 2023 Aug 1;204:54-67
Cold atmospheric plasma alleviates radiation-induced skin injury by suppressing inflammation and promoting repair.
Ma L, Chen Y, Gong Q, Cheng Z, Ran C, Liu K, Shi C
Free radical biology & medicine 2023 Aug 1;204:184-194
Free radical biology & medicine 2023 Aug 1;204:184-194
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis.
Wang F, Guo K, Nan L, Wang S, Lu J, Wang Q, Ba Z, Huang Y, Wu D
Free radical biology & medicine 2023 Aug 1;204:128-150
Free radical biology & medicine 2023 Aug 1;204:128-150
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
Wang Y, Tang B, Li H, Zheng J, Zhang C, Yang Z, Tan X, Luo P, Ma L, Wang Y, Long L, Chen Z, Xiao Z, Ma L, Zhou J, Wang Y, Shi C
EBioMedicine 2023 Apr;90:104480
EBioMedicine 2023 Apr;90:104480
Pterostilbene ameliorates oxidative damage and ferroptosis in human ovarian granulosa cells by regulating the Nrf2/HO-1 pathway.
Chen X, Song QL, Li ZH, Ji R, Wang JY, Cao ML, Mu XF, Zhang Y, Guo DY, Yang J
Archives of biochemistry and biophysics 2023 Apr;738:109561
Archives of biochemistry and biophysics 2023 Apr;738:109561
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Wang Y, Chen X, Baker JS, Davison GW, Xu S, Zhou Y, Bao X
European journal of nutrition 2023 Apr;62(3):1453-1466
European journal of nutrition 2023 Apr;62(3):1453-1466
Ginsenoside Rd promotes omentin secretion in adipose through TBK1-AMPK to improve mitochondrial biogenesis via WNT5A/Ca(2+) pathways in heart failure.
Wan S, Cui Z, Wu L, Zhang F, Liu T, Hu J, Tian J, Yu B, Liu F, Kou J, Li F
Redox biology 2023 Apr;60:102610
Redox biology 2023 Apr;60:102610
Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent manner.
Chen Y, Zhu S, Lin Z, Zhang Y, Jin C, He S, Chen X, Zhou X
Molecular biology reports 2023 Apr;50(4):3469-3478
Molecular biology reports 2023 Apr;50(4):3469-3478
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Shen Y, Teng L, Qu Y, Huang Y, Peng Y, Tang M, Fu Q
Inflammation 2023 Apr;46(2):655-678
Inflammation 2023 Apr;46(2):655-678
JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice.
Xie Z, Wu XJ, Cheng RW, Cui JH, Yuan ST, Zhou JW, Liu QH
Acta pharmacologica Sinica 2023 Apr;44(4):897-912
Acta pharmacologica Sinica 2023 Apr;44(4):897-912
Ampicillin exacerbates acetaminophen-induced acute liver injury by inducing intestinal microbiota imbalance and butyrate reduction.
Li ZM, Kong CY, Mao YQ, Huang JT, Chen HL, Han B, Wang LS
Liver international : official journal of the International Association for the Study of the Liver 2023 Apr;43(4):865-877
Liver international : official journal of the International Association for the Study of the Liver 2023 Apr;43(4):865-877
Dimethyl fumarate protects against hepatic ischemia-reperfusion injury by alleviating ferroptosis via the NRF2/SLC7A11/HO-1 axis.
Qi D, Chen P, Bao H, Zhang L, Sun K, Song S, Li T
Cell cycle (Georgetown, Tex.) 2023 Apr;22(7):818-828
Cell cycle (Georgetown, Tex.) 2023 Apr;22(7):818-828
Ameliorative effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 signaling pathway.
Hu Y, Yan Z, He Y, Li Y, Li M, Li Y, Zhang D, Zhao Y, Ommati MM, Wang J, Huo M, Wang J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113647
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113647
Isosinensetin alleviates estrogen deficiency-induced osteoporosis via suppressing ROS-mediated NF-κB/MAPK signaling pathways.
Qin Y, Song D, Liao S, Chen J, Xu M, Su Y, Lian H, Peng H, Wei L, Chen K, Xu J, Zhao J, Liu Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114347
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114347
Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs.
Li D, Shen L, Zhang D, Wang X, Wang Q, Qin W, Gao Y, Li X
Journal of environmental sciences (China) 2023 Apr;126:683-696
Journal of environmental sciences (China) 2023 Apr;126:683-696
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Dong C, Song C, He Z, Song Q, Song T, Liu J, Xiong Y, Su X, Zhou J, Yang S, Liao W
International immunopharmacology 2023 Apr;117:110042
International immunopharmacology 2023 Apr;117:110042
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
Chen H, Qi X, Guan K, Wang R, Li Q, Ma Y
Journal of dairy science 2023 Apr;106(4):2271-2288
Journal of dairy science 2023 Apr;106(4):2271-2288
Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion.
Zhang X, Yang X, Zhang S, Wang J, Wang M, Ma T, Wan M, Lv X, Yan T, Jia Y
The Journal of pharmacy and pharmacology 2023 Apr 7;75(4):574-584
The Journal of pharmacy and pharmacology 2023 Apr 7;75(4):574-584
Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-κB pathways.
Li J, Lu Q, Peng M, Liao J, Zhang B, Yang D, Huang P, Yang Y, Zhao Q, Han B, Li J
Journal of ethnopharmacology 2023 Apr 6;305:116069
Journal of ethnopharmacology 2023 Apr 6;305:116069
A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns.
Tang Y, Han Y, Zhao J, Lv Y, Fan C, Zheng L, Zhang Z, Liu Z, Li C, Lin Y
Nano-micro letters 2023 Apr 30;15(1):112
Nano-micro letters 2023 Apr 30;15(1):112
Synthesis of Lathyrol PROTACs and Evaluation of Their Anti-Inflammatory Activities.
Wang W, Liu Y, Xiong L, Sun D, Wang H, Song Z, Li Y, Li H, Chen L
Journal of natural products 2023 Apr 28;86(4):767-781
Journal of natural products 2023 Apr 28;86(4):767-781
Continuous Monochromatic Blue Light Exacerbates High-Fat Diet-Induced Kidney Injury via Corticosterone-Mediated Oxidative Stress.
Ren W, Wang Z, Cao J, Dong Y, Wang T, Chen Y
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
Iron Saturation Drives Lactoferrin Effects on Oxidative Stress and Neurotoxicity Induced by HIV-1 Tat.
Ianiro G, D'Ezio V, Carpinelli L, Casella C, Bonaccorsi di Patti MC, Rosa L, Valenti P, Colasanti M, Musci G, Cutone A, Persichini T
International journal of molecular sciences 2023 Apr 27;24(9)
International journal of molecular sciences 2023 Apr 27;24(9)
Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling.
Wang G, Qin S, Chen L, Geng H, Zheng Y, Xia C, Yao J, Deng L
Cell death & disease 2023 Apr 25;14(4):292
Cell death & disease 2023 Apr 25;14(4):292
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Xu L, Cai J, Li C, Yang M, Duan T, Zhao Q, Xi Y, Sun L, He L, Tang C, Sun L
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2.
Zhang FL, Chen XW, Wang YF, Hu Z, Zhang WJ, Zhou BW, Ci PF, Liu KX
Journal of translational medicine 2023 Apr 18;21(1):264
Journal of translational medicine 2023 Apr 18;21(1):264
Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species.
Wang Q, Peng X, Chen Y, Tang X, Qin Y, He M, Chen W, Chen H
Biochemical and biophysical research communications 2023 Apr 16;652:88-94
Biochemical and biophysical research communications 2023 Apr 16;652:88-94
Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway.
Zhao Y, Li Y, Li H, Shi S
Experimental cell research 2023 Apr 15;425(2):113542
Experimental cell research 2023 Apr 15;425(2):113542
Variable p53/Nrf2 crosstalk contributes to triptolide-induced hepatotoxic process.
Hou Z, Yan M, Li H, Wang W, You S, Wang M, Du T, Gong H, Li W, Guo L, Wei S, Zhang B, Ji M, Chen X
Toxicology letters 2023 Apr 15;379:67-75
Toxicology letters 2023 Apr 15;379:67-75
Involvements of Nrf2 and oxidative stress in the ozone-elicited exacerbation in an allergic rhinitis model.
Sun N, Huang Y, Zhang X, Niu Y, Duan Y, Kan H, Zhang R
Ecotoxicology and environmental safety 2023 Apr 15;255:114822
Ecotoxicology and environmental safety 2023 Apr 15;255:114822
Polysaccharides extracted from mulberry fruits (Morus nigra L.): antioxidant effect of ameliorating H(2)O(2)-induced liver injury in HepG2 cells.
Li X, Hua Y, Yang C, Liu S, Tan L, Guo J, Li Y
BMC complementary medicine and therapies 2023 Apr 12;23(1):112
BMC complementary medicine and therapies 2023 Apr 12;23(1):112
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
Li J, Bai J, Si X, Jia H, Wu Z
Chemico-biological interactions 2023 Apr 1;374:110386
Chemico-biological interactions 2023 Apr 1;374:110386
Blue LED light induces cytotoxicity via ROS production and mitochondrial damage in bovine subcutaneous preadipocytes.
Hao W, Zhao C, Li G, Wang H, Li T, Yan P, Wei S
Environmental pollution (Barking, Essex : 1987) 2023 Apr 1;322:121195
Environmental pollution (Barking, Essex : 1987) 2023 Apr 1;322:121195
Traditional Chinese medicine prescriptions (XJZ, JSS) ameliorate spleen inflammatory response and antioxidant capacity by synergistically regulating NF-κB and Nrf2 signaling pathways in piglets.
Chen J, Hu N, Mao Y, Hu A, Jiang W, Huang A, Wang Y, Meng P, Hu M, Yang X, Cao Y, Yang F, Cao H
Frontiers in veterinary science 2022;9:993018
Frontiers in veterinary science 2022;9:993018
Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats.
Liang Z, Miao Y, Teng X, Xiao L, Guo Q, Xue H, Tian D, Jin S, Wu Y
Frontiers in molecular biosciences 2022;9:947778
Frontiers in molecular biosciences 2022;9:947778
Adaptive mechanisms in no flow vs. low flow ischemia in equine jejunum epithelium: Different paths to the same destination.
Dengler F, Sternberg F, Grages M, Kästner SB, Verhaar N
Frontiers in veterinary science 2022;9:947482
Frontiers in veterinary science 2022;9:947482
The beneficial effects of traditional Chinese medicine on antioxidative status and inflammatory cytokines expression in the liver of piglets.
Wang X, Wang Y, Mao Y, Hu A, Xu T, Yang Y, Wang F, Zhou G, Guo X, Cao H, Yang F
Frontiers in veterinary science 2022;9:937745
Frontiers in veterinary science 2022;9:937745
Rutin Supplementation Reduces Oxidative Stress, Inflammation and Apoptosis of Mammary Gland in Sheep During the Transition Period.
Ding H, Li Y, Zhao C, Yang Y, Xiong C, Zhang D, Feng S, Wu J, Wang X
Frontiers in veterinary science 2022;9:907299
Frontiers in veterinary science 2022;9:907299
The Protective Effect of Sulforaphane on Dextran Sulfate Sodium-Induced Colitis Depends on Gut Microbial and Nrf2-Related Mechanism.
He C, Gao M, Zhang X, Lei P, Yang H, Qing Y, Zhang L
Frontiers in nutrition 2022;9:893344
Frontiers in nutrition 2022;9:893344
Trans-anethole Ameliorates Intestinal Injury Through Activation of Nrf2 Signaling Pathway in Subclinical Necrotic Enteritis-Induced Broilers.
Yu C, Tong Y, Li Q, Wang T, Yang Z
Frontiers in veterinary science 2022;9:877066
Frontiers in veterinary science 2022;9:877066
Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress.
Zou P, Zhang X, Zhang R, Chai X, Zhao Y, Li E, Zhang Q, Yan R, Yang J, Liao B
Frontiers in molecular biosciences 2022;9:853654
Frontiers in molecular biosciences 2022;9:853654
Using Collagen Peptides From the Skin of Monkfish (Lophius litulon) to Ameliorate Kidney Damage in High-Fat Diet Fed Mice by Regulating the Nrf2 Pathway and NLRP3 Signaling.
Miao B, Zheng J, Zheng G, Tian X, Zhang W, Yuan F, Yang Z
Frontiers in nutrition 2022;9:798708
Frontiers in nutrition 2022;9:798708
Effects of folic acid on oxidative damage of kidney in lead-exposed rats.
Li N, Wen L, Yu Z, Li T, Wang T, Qiao M, Song L, Huang X
Frontiers in nutrition 2022;9:1035162
Frontiers in nutrition 2022;9:1035162
Tannic acid attenuates intestinal oxidative damage by improving antioxidant capacity and intestinal barrier in weaned piglets and IPEC-J2 cells.
Wang M, Huang H, Wang L, Yin L, Yang H, Chen C, Zheng Q, He S
Frontiers in nutrition 2022;9:1012207
Frontiers in nutrition 2022;9:1012207
Tanshinone IIA Regulates Keap1/Nrf2 Signal Pathway by Activating Sestrin2 to Restrain Pulmonary Fibrosis.
Li H, Wu M, Guo C, Zhai R, Chen J
The American journal of Chinese medicine 2022;50(8):2125-2151
The American journal of Chinese medicine 2022;50(8):2125-2151
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance.
Lyu Y, Ren XK, Guo CC, Li ZF, Zheng JP
The Journal of toxicological sciences 2022;47(12):519-529
The Journal of toxicological sciences 2022;47(12):519-529
Corrigendum to "Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway".
Ding B, Geng S, Hou X, Ma X, Xu H, Yang F, Liu K, Liang W, Ma G
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9828973
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9828973
Fibroblast Growth Factor 19 Improves LPS-Induced Lipid Disorder and Organ Injury by Regulating Metabolomic Characteristics in Mice.
Liu T, Tang X, Cui Y, Xiong X, Xu Y, Hu S, Feng S, Shao L, Ren Y, Miao H, Zhang H, Zhu X, Zhang Y, Wang C
Oxidative medicine and cellular longevity 2022;2022:9673512
Oxidative medicine and cellular longevity 2022;2022:9673512
Carbon Monoxide-Releasing Molecule-3 Suppresses the Malignant Biological Behavior of Tongue Squamous Cell Carcinoma via Regulating Keap1/Nrf2/HO-1 Signaling Pathway.
Dai Y, Chen H, Pan Y, Song H
BioMed research international 2022;2022:9418332
BioMed research international 2022;2022:9418332
Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway.
Gao Y, Hu M, Niu X, Li M, Xu L, Xiao Y, Zhang J, Wang H, Li L, Chu B, Lv P
Oxidative medicine and cellular longevity 2022;2022:8652741
Oxidative medicine and cellular longevity 2022;2022:8652741
NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules.
Zhang H, Chen C, Liu Y, Ren L, Qi J, Yang Y, Chen W, Yao Y, Cai X, Liu Z, Hao M, Li L, Deng Z, Sun M, Lu Y, Chen K, Hou P
Oxidative medicine and cellular longevity 2022;2022:8488269
Oxidative medicine and cellular longevity 2022;2022:8488269
Exosomes Derived from Baicalin-Pretreated Mesenchymal Stem Cells Alleviate Hepatocyte Ferroptosis after Acute Liver Injury via the Keap1-NRF2 Pathway.
Zhao S, Huang M, Yan L, Zhang H, Shi C, Liu J, Zhao S, Liu H, Wang B
Oxidative medicine and cellular longevity 2022;2022:8287227
Oxidative medicine and cellular longevity 2022;2022:8287227
Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R(-)/(-)) Mice.
Li W, Zhang H, Zhang L, Zhang T, Ding H
BioMed research international 2022;2022:7709926
BioMed research international 2022;2022:7709926
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Wang P, Zhang S, Liu W, Chen S, Lv X, Hu B, Shao Z
Oxidative medicine and cellular longevity 2022;2022:7531788
Oxidative medicine and cellular longevity 2022;2022:7531788
Metabolism-Related Gene TXNRD1 Regulates Inflammation and Oxidative Stress Induced by Cigarette Smoke through the Nrf2/HO-1 Pathway in the Small Airway Epithelium.
Huang Q, Peng M, Gu Y, Wu J, Zhan Y, Deng Z, Chen S, Yang R, Chen J, Xie J
Oxidative medicine and cellular longevity 2022;2022:7067623
Oxidative medicine and cellular longevity 2022;2022:7067623
Paeoniflorin Regulates NEDD4L/STAT3 Pathway to Induce Ferroptosis in Human Glioma Cells.
Nie XH, Qiu S, Xing Y, Xu J, Lu B, Zhao SF, Li YT, Su ZZ
Journal of oncology 2022;2022:6093216
Journal of oncology 2022;2022:6093216
Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway.
Zhang B, Wan S, Liu H, Qiu Q, Chen H, Chen Z, Wang L, Liu X
Oxidative medicine and cellular longevity 2022;2022:5992436
Oxidative medicine and cellular longevity 2022;2022:5992436
Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity.
Shi H, Yan Y, Yang H, Pu P, Tang H
BioMed research international 2022;2022:5623555
BioMed research international 2022;2022:5623555
Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin-Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway.
Liu Y, Huang P, Li Z, Xu C, Wang H, Jia B, Gong A, Xu M
Oxidative medicine and cellular longevity 2022;2022:5361241
Oxidative medicine and cellular longevity 2022;2022:5361241
Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue.
Han GJ, Min XZ, Ma SS, Ding C, Wang XQ
Oxidative medicine and cellular longevity 2022;2022:5126042
Oxidative medicine and cellular longevity 2022;2022:5126042
Tripeptide Leu-Pro-Phe from Corn Protein Hydrolysates Attenuates Hyperglycemia-Induced Neural Tube Defect in Chicken Embryos.
Yan CY, Sun J, Yu GY, Liu JH, Huang RP, Han SC, Zhang QY, Li XM, Yan JG, Kurihara H, Li WX, Li YF, He RR
Oxidative medicine and cellular longevity 2022;2022:4932304
Oxidative medicine and cellular longevity 2022;2022:4932304
Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis.
Huang YB, Jiang L, Liu XQ, Wang X, Gao L, Zeng HX, Zhu W, Hu XR, Wu YG
Oxidative medicine and cellular longevity 2022;2022:4776243
Oxidative medicine and cellular longevity 2022;2022:4776243
Homeobox A1 Facilitates Immune Escape and Alleviates Oxidative Stress in Lung Adenocarcinoma.
Zhao F, Tian H, Liu X, Guan Y, Zhu Y, Ren P, Zhang J, Dong Y, Fu L
Oxidative medicine and cellular longevity 2022;2022:4102666
Oxidative medicine and cellular longevity 2022;2022:4102666
Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2'-Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester.
Guan D, Zhou W, Wei H, Wang T, Zheng K, Yang C, Feng R, Xu R, Fu Y, Li C, Li Y, Li C
Oxidative medicine and cellular longevity 2022;2022:3920664
Oxidative medicine and cellular longevity 2022;2022:3920664
HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation.
Han S, Lin F, Qi Y, Liu C, Zhou L, Xia Y, Chen K, Xing J, Liu Z, Yu W, Zhang Y, Zhou X, Rao T, Cheng F
Oxidative medicine and cellular longevity 2022;2022:3846217
Oxidative medicine and cellular longevity 2022;2022:3846217
Theaflavin-3,3'-Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis.
Xu C, Ni S, Xu N, Yin G, Yu Y, Zhou B, Zhao G, Wang L, Zhu R, Jiang S, Wang Y
Oxidative medicine and cellular longevity 2022;2022:3531995
Oxidative medicine and cellular longevity 2022;2022:3531995
Theaflavin-3,3'-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways.
Teng Y, Jin Z, Ren W, Lu M, Hou M, Zhou Q, Wang W, Yang H, Zou J
Oxidative medicine and cellular longevity 2022;2022:3047425
Oxidative medicine and cellular longevity 2022;2022:3047425
Streptococcus lutetiensis Induces Autophagy via Oxidative Stress in Bovine Mammary Epithelial Cells.
Chen P, Yang J, Wu N, Han B, Kastelic JP, Gao J
Oxidative medicine and cellular longevity 2022;2022:2549772
Oxidative medicine and cellular longevity 2022;2022:2549772
Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice.
Zhang Y, Liu Y, Liu X, Yuan X, Xiang M, Liu J, Zhang L, Zhu S, Lu J, Tang Q, Cheng S
Oxidative medicine and cellular longevity 2022;2022:2297268
Oxidative medicine and cellular longevity 2022;2022:2297268
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Wang L, Wang J
Oxidative medicine and cellular longevity 2022;2022:1755608
Oxidative medicine and cellular longevity 2022;2022:1755608
TRPV1 Modulator Ameliorates Alzheimer-Like Amyloid-β Neuropathology via Akt/Gsk3β-Mediated Nrf2 Activation in the Neuro-2a/APP Cell Model.
Wang X, Bian Y, Wong CTT, Lu JH, Lee SM
Oxidative medicine and cellular longevity 2022;2022:1544244
Oxidative medicine and cellular longevity 2022;2022:1544244
Ginsenoside Rg1 Reduces Oxidative Stress Via Nrf2 Activation to Regulate Age-Related Mesenchymal Stem Cells Fate Switch Between Osteoblasts and Adipocytes.
Hou J, Wang L, Wang C, Ma R, Wang Z, Xiao H, Zeng D, Ling L, Wang Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1411354
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1411354
Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury.
Mao Y, Du J, Chen X, Al Mamun A, Cao L, Yang Y, Mubwandarikwa J, Zaeem M, Zhang W, Chen Y, Dai Y, Xiao J, Ye K
Oxidative medicine and cellular longevity 2022;2022:1337630
Oxidative medicine and cellular longevity 2022;2022:1337630
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway.
Li Q, Tan JX, He Y, Bai F, Li SW, Hou YW, Ji LS, Gao YT, Zhang X, Zhou ZH, Yu Z, Fang M, Gao YQ, Li M
International journal of biological sciences 2022;18(4):1594-1611
International journal of biological sciences 2022;18(4):1594-1611
Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane.
Gao X, Al-Baadani MA, Wu M, Tong N, Shen X, Ding X, Liu J
International journal of nanomedicine 2022;17:17-29
International journal of nanomedicine 2022;17:17-29
Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model.
Xiao S, Zhou Y, Wang Q, Yang D
Drug design, development and therapy 2022;16:4411-4428
Drug design, development and therapy 2022;16:4411-4428
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Wang J, Zhang Y, Zhang M, Sun S, Zhong Y, Han L, Xu Y, Wan D, Zhang J, Zhu H
Drug design, development and therapy 2022;16:279-296
Drug design, development and therapy 2022;16:279-296
Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.
Huang S, Wang Y, Xie S, Lai Y, Mo C, Zeng T, Kuang S, Deng G, Zhou C, Chen Y, Huang S, Gao L, Lv Z
Cellular and molecular gastroenterology and hepatology 2022;13(6):1649-1672
Cellular and molecular gastroenterology and hepatology 2022;13(6):1649-1672
Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress.
Jia Z, Wang P, Xu Y, Feng G, Wang Q, He X, Song Y, Liu P, Chen J
Frontiers in pharmacology 2022;13:986510
Frontiers in pharmacology 2022;13:986510
Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.
Wang J, Wang K, Ding L, Zhao P, Zhang C, Wang H, Yang Z, Liu Z
Frontiers in pharmacology 2022;13:969892
Frontiers in pharmacology 2022;13:969892
Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.
Jiang Z, Qi G, Lu W, Wang H, Li D, Chen W, Ding L, Yang X, Yuan H, Zeng Q
Frontiers in pharmacology 2022;13:952950
Frontiers in pharmacology 2022;13:952950
Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer's disease.
Li J, Zou B, Cheng XY, Yang XH, Li J, Zhao CH, Ma RX, Tian JX, Yao Y
Frontiers in pharmacology 2022;13:940999
Frontiers in pharmacology 2022;13:940999
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Shao Y, Sun L, Yang G, Wang W, Liu X, Du T, Chen F, Jing X, Cui X
Frontiers in pharmacology 2022;13:937502
Frontiers in pharmacology 2022;13:937502
Caryophyllene Oxide Induces Ferritinophagy by Regulating the NCOA4/FTH1/LC3 Pathway in Hepatocellular Carcinoma.
Xiu Z, Zhu Y, Han J, Li Y, Yang X, Yang G, Song G, Li S, Li Y, Cheng C, Li Y, Fang J, Li X, Jin N
Frontiers in pharmacology 2022;13:930958
Frontiers in pharmacology 2022;13:930958
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
Yang T, Lin X, Li H, Zhou X, Fan F, Yang J, Luo Y, Liu X
Frontiers in pharmacology 2022;13:927871
Frontiers in pharmacology 2022;13:927871
Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs.
Li D, Zhao H, Xu P, Lin Q, Zhao T, Li C, Cui ZK, Tian G
Frontiers in pharmacology 2022;13:887833
Frontiers in pharmacology 2022;13:887833
Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation.
Biao Y, Chen J, Liu C, Wang R, Han X, Li L, Zhang Y
Frontiers in pharmacology 2022;13:877924
Frontiers in pharmacology 2022;13:877924
Naringin Relieves Diabetic Cardiac Autonomic Neuropathy Mediated by P2Y(14) Receptor in Superior Cervical Ganglion.
Tang G, Pi L, Guo H, Hu Z, Zhou C, Hu Q, Peng H, Xiao Z, Zhang Z, Wang M, Peng T, Huang J, Liang S, Li G
Frontiers in pharmacology 2022;13:873090
Frontiers in pharmacology 2022;13:873090
Kaempferol From Penthorum chinense Pursh Attenuates Hepatic Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Inflammation Through Activation of the Nrf2/HO-1 Signaling Pathway.
Chen Y, Li T, Tan P, Shi H, Cheng Y, Cai T, Bai J, Du Y, Fu W
Frontiers in pharmacology 2022;13:857015
Frontiers in pharmacology 2022;13:857015
Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling.
Qin X, Liu B, Gao F, Hu Y, Chen Z, Xu J, Zhang X
Frontiers in physiology 2022;13:856699
Frontiers in physiology 2022;13:856699
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
Chen R, Zeng J, Li C, Xiao H, Li S, Lin Z, Huang K, Shen J, Huang H
Frontiers in pharmacology 2022;13:853383
Frontiers in pharmacology 2022;13:853383
Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1.
Shi H, Hou B, Li H, Zhou H, Du B
Frontiers in pharmacology 2022;13:839464
Frontiers in pharmacology 2022;13:839464
Sleeve Gastrectomy-Induced AMPK Activation Attenuates Diabetic Cardiomyopathy by Maintaining Mitochondrial Homeostasis via NR4A1 Suppression in Rats.
Li S, Dong S, Xu Q, Shi B, Li L, Zhang W, Zhu J, Cheng Y, Zhang G, Zhong M
Frontiers in physiology 2022;13:837798
Frontiers in physiology 2022;13:837798
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Guo J, Hu H, Chen Z, Xu J, Nie J, Lu J, Ma L, Ji H, Yuan J, Xu B
Frontiers in physiology 2022;13:822348
Frontiers in physiology 2022;13:822348
Nrf2 Signaling Pathway Mediates the Protective Effects of Daphnetin Against D-Galactose Induced-Premature Ovarian Failure.
Zhang M, Yu X, Li D, Ma N, Wei Z, Ci X, Zhang S
Frontiers in pharmacology 2022;13:810524
Frontiers in pharmacology 2022;13:810524
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.
Guo Z, Lin J, Sun K, Guo J, Yao X, Wang G, Hou L, Xu J, Guo J, Guo F
Frontiers in pharmacology 2022;13:791376
Frontiers in pharmacology 2022;13:791376
Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway.
Ma T, Jia L, Zhao J, Lv L, Yu Y, Ruan H, Song X, Chen H, Li X, Zhang J, Gao L
Frontiers in pharmacology 2022;13:1027553
Frontiers in pharmacology 2022;13:1027553
Yinchen Linggui Zhugan decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease by modulation of SIRT1/Nrf2 signaling pathway and gut microbiota.
Jiang H, Mao T, Sun Z, Shi L, Han X, Zhang Y, Zhang X, Wang J, Hu J, Zhang L, Li J, Han H
Frontiers in microbiology 2022;13:1001778
Frontiers in microbiology 2022;13:1001778
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Liu H, Zhao L, Wang M, Yang K, Jin Z, Zhao C, Shi G
Frontiers in oncology 2022;12:852095
Frontiers in oncology 2022;12:852095
WASH regulates the oxidative stress Nrf2/ARE pathway to inhibit proliferation and promote apoptosis of HeLa cells under the action of Jolkinolide B.
Hong Y, Liu J, Kong W, Li H, Cui Y, Liu Y, Deng Z, Ma D, Zhang K, Li J, Li M
PeerJ 2022;10:e13499
PeerJ 2022;10:e13499
Theaflavin Attenuates TBHP-Induced Endothelial Cells Oxidative Stress by Activating PI3K/AKT/Nrf2 and Accelerates Wound Healing in Rats.
Chen D, Wu Z, Wu LN, Jiang J, Hu GN
Frontiers in bioengineering and biotechnology 2022;10:830574
Frontiers in bioengineering and biotechnology 2022;10:830574
Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.
Jing S, Wan J, Wang T, He Z, Ding Q, Sheng G, Wang S, Zhao H, Zhu Z, Wu H, Li W
Frontiers in bioengineering and biotechnology 2022;10:1071776
Frontiers in bioengineering and biotechnology 2022;10:1071776
Cytoglobin inhibits non-thermal plasma-induced apoptosis in melanoma cells through regulation of the NRF2-mediated antioxidant response.
De Backer J, Lin A, Berghe WV, Bogaerts A, Hoogewijs D
Redox biology 2022 Sep;55:102399
Redox biology 2022 Sep;55:102399
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
Guo W, Long X, Lv M, Deng S, Liu D, Yang Q
The Journal of international medical research 2022 Sep;50(9):3000605221118680
The Journal of international medical research 2022 Sep;50(9):3000605221118680
Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection.
Xi J, Zhang Z, Wang Z, Wu Q, He Y, Xu Y, Ding Z, Zhao H, Da H, Zhang F, Zhao H, Fang J
Free radical biology & medicine 2022 Sep;190:202-215
Free radical biology & medicine 2022 Sep;190:202-215
Colchicine improves severe acute pancreatitis-induced acute lung injury by suppressing inflammation, apoptosis and oxidative stress in rats.
Zhang D, Li L, Li J, Wei Y, Tang J, Man X, Liu F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113461
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113461
Chaihujialonggumulitang shows psycho-cardiology therapeutic effect on acute myocardial infarction with comorbid anxiety by the activation of Nrf2/HO-1 pathway and suppression of oxidative stress and apoptosis.
Shi J, Hou J, Sun Y, Jia Z, Zhou Y, Wang C, Zhao H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113437
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113437
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Shen Y, Fan X, Qu Y, Tang M, Huang Y, Peng Y, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
1,3-Dichloro-2-propanol-Induced Renal Tubular Cell Necroptosis through the ROS/RIPK3/MLKL Pathway.
Fan Y, Lu J, Yu Z, Qu X, Guan S
Journal of agricultural and food chemistry 2022 Sep 7;70(35):10847-10857
Journal of agricultural and food chemistry 2022 Sep 7;70(35):10847-10857
Hawk Tea Flavonoids as Natural Hepatoprotective Agents Alleviate Acute Liver Damage by Reshaping the Intestinal Microbiota and Modulating the Nrf2 and NF-κB Signaling Pathways.
Xu T, Hu S, Liu Y, Sun K, Luo L, Zeng L
Nutrients 2022 Sep 5;14(17)
Nutrients 2022 Sep 5;14(17)
Omarigliptin Mitigates 6-Hydroxydopamine- or Rotenone-Induced Oxidative Toxicity in PC12 Cells by Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Actions.
Gouda NA, Cho J
Antioxidants (Basel, Switzerland) 2022 Sep 28;11(10)
Antioxidants (Basel, Switzerland) 2022 Sep 28;11(10)
IDH1 Promotes Foam Cell Formation by Aggravating Macrophage Ferroptosis.
Li B, Wang C, Lu P, Ji Y, Wang X, Liu C, Lu X, Xu X, Wang X
Biology 2022 Sep 23;11(10)
Biology 2022 Sep 23;11(10)
Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway.
Luo JF, Zhou H, Lio CK
Molecules (Basel, Switzerland) 2022 Sep 22;27(19)
Molecules (Basel, Switzerland) 2022 Sep 22;27(19)
Fucoxanthin ameliorated myocardial fibrosis in STZ-induced diabetic rats and cell hypertrophy in HG-induced H9c2 cells by alleviating oxidative stress and restoring mitophagy.
Zheng D, Chen L, Li G, Jin L, Wei Q, Liu Z, Yang G, Li Y, Xie X
Food & function 2022 Sep 22;13(18):9559-9575
Food & function 2022 Sep 22;13(18):9559-9575
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
He D, Liu Y, Li J, Wang H, Ye B, He Y, Li Z, Gao X, Fu S, Liu D
Cells 2022 Sep 19;11(18)
Cells 2022 Sep 19;11(18)
Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling.
Wang K, Tang Y, Wu X, Liang H, Chen D, Yu B, He J, Mao X, Huang Z, Yan H, Wu A, Luo Y, Zheng P, Yu J, Wang H, Luo J
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Glucose Increases Hepatic Mitochondrial Antioxidant Enzyme Activities in Insulin Resistant Rats Following Chronic Angiotensin Receptor Blockade.
Godoy-Lugo JA, Thorwald MA, Mendez DA, Rodriguez R, Nakano D, Nishiyama A, Ortiz RM
International journal of molecular sciences 2022 Sep 17;23(18)
International journal of molecular sciences 2022 Sep 17;23(18)
A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells.
Zhang XG, Liu AX, Zhang YX, Zhou MY, Li XY, Fu MH, Pan YP, Xu J, Zhang JQ
Journal of ethnopharmacology 2022 Sep 15;295:115397
Journal of ethnopharmacology 2022 Sep 15;295:115397
Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.
Bondi CD, Rush BM, Hartman HL, Wang J, Al-Bataineh MM, Hughey RP, Tan RJ
Antioxidants (Basel, Switzerland) 2022 Sep 14;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 14;11(9)
Carbon tetrachloride exposure induces ovarian damage through oxidative stress and inflammatory mediated ovarian fibrosis.
Xue L, Li X, Zhu X, Zhang J, Zhou S, Tang W, Chen D, Chen Y, Dai J, Wu M, Wu M, Wang S
Ecotoxicology and environmental safety 2022 Sep 1;242:113859
Ecotoxicology and environmental safety 2022 Sep 1;242:113859
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway.
Chen TY, Zheng SK
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):830-839
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):830-839
Quercetin in Tonglong Qibi decoction ameliorates testosterone-induced benign prostatic hyperplasia in rats by regulating Nrf2 signalling pathways and oxidative stress.
Fu W, Chen S, Zhang Z, Chen Y, You X, Li Q
Andrologia 2022 Oct;54(9):e14502
Andrologia 2022 Oct;54(9):e14502
Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects.
Ye C, Geng Z, Zhang LL, Zheng F, Zhou YB, Zhu GQ, Xiong XQ
Acta pharmacologica Sinica 2022 Oct;43(10):2573-2584
Acta pharmacologica Sinica 2022 Oct;43(10):2573-2584
Antihepatofibrotic effect of Guizhifuling pill on carbon tetrachloride-induced liver fibrosis in mice.
Baogui XU, Jiawen Z, Xiaoxiao T, Falei Y, Zhongliang L, Zuisu Y, Xianjun D
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):715-722
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):715-722
CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway.
Ren X, Yu J, Guo L, Zhang Z
Metabolic brain disease 2022 Oct;37(7):2417-2429
Metabolic brain disease 2022 Oct;37(7):2417-2429
Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO-1 signaling pathway in mice.
Xu L, Gao Y, Hu M, Dong Y, Xu J, Zhang J, Lv P
Fundamental & clinical pharmacology 2022 Oct;36(5):790-800
Fundamental & clinical pharmacology 2022 Oct;36(5):790-800
Effects of Inorganic and Organic Manganese Supplementation on Growth Performance, Tibia Development, and Oxidative Stress in Broiler Chickens.
Xia WH, Tang L, Wang ZY, Wang L
Biological trace element research 2022 Oct;200(10):4453-4464
Biological trace element research 2022 Oct;200(10):4453-4464
Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling.
Zhang Y, Yang S, Qiu Z, Huang L, Huang L, Liang Y, Liu X, Wang M, Zhou B
Free radical biology & medicine 2022 Oct;191:66-81
Free radical biology & medicine 2022 Oct;191:66-81
LipoxinA(4) analog BML-111 protects podocytes cultured in high-glucose medium against oxidative injury via activating Nrf2 pathway.
Hao H, Xie F, Xu F, Wang Q, Wu Y, Zhang D
International immunopharmacology 2022 Oct;111:109170
International immunopharmacology 2022 Oct;111:109170
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Qu Y, Shen Y, Teng L, Huang Y, Yang Y, Jian X, Fan S, Wu P, Fu Q
International immunopharmacology 2022 Oct;111:109129
International immunopharmacology 2022 Oct;111:109129
Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury.
Xia M, Zhang Y, Wu H, Zhang Q, Liu Q, Li G, Zhao T, Liu X, Zheng S, Qian Z, Li H
International immunopharmacology 2022 Oct;111:109120
International immunopharmacology 2022 Oct;111:109120
Immature rat testis sustained long-term development using an integrative model.
Ma Y, Chen J, Li H, Xu F, Chong T, Wang Z, Zhang L
Biological research 2022 Oct 4;55(1):30
Biological research 2022 Oct 4;55(1):30
DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway.
Chu X, Zhong L, Dan W, Wang X, Zhang Z, Liu Z, Lu Y, Shao X, Zhou Z, Chen S, Liu B
Cell communication and signaling : CCS 2022 Oct 27;20(1):168
Cell communication and signaling : CCS 2022 Oct 27;20(1):168
Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease.
Zhao H, Xian G, Zeng J, Zhong G, An D, Peng Y, Hu D, Lin Y, Li J, Su S, Ning Y, Xu D, Zeng Q
Antioxidants (Basel, Switzerland) 2022 Oct 24;11(11)
Antioxidants (Basel, Switzerland) 2022 Oct 24;11(11)
Potential contribution of early endothelial progenitor cell (eEPC)-to-macrophage switching in the development of pulmonary plexogenic lesion.
Shao FJ, Guo XL, Xu JX, Liu R, Li DY, Li QH, Zhou T, Fang C, Tan X
Respiratory research 2022 Oct 23;23(1):290
Respiratory research 2022 Oct 23;23(1):290
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise.
Barsky ST, Monks DA
Biology of sex differences 2022 Oct 23;13(1):59
Biology of sex differences 2022 Oct 23;13(1):59
Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems.
Nakahara E, Mullapudi V, Collier GE, Joachimiak LA, Hulleman JD
ACS chemical biology 2022 Oct 21;17(10):2877-2889
ACS chemical biology 2022 Oct 21;17(10):2877-2889
PLK-1 Interacting Checkpoint Helicase, PICH, Mediates Cellular Oxidative Stress Response.
Dutta A, Das A, Bisht D, Arya V, Muthuswami R
Epigenomes 2022 Oct 18;6(4)
Epigenomes 2022 Oct 18;6(4)
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages.
Yang T, Zhao Q, Hu M, Pan S, Zhang L, Zhu R, Zhou B, Feng X, Gao Z, Zhu Z, Zhang Y, Hu L, Liu F, Shan Z
Antioxidants (Basel, Switzerland) 2022 Oct 18;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 18;11(10)
Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy.
Fan H, Cui J, Liu F, Zhang W, Yang H, He N, Dong Z, Dong J
European journal of pharmacology 2022 Oct 15;933:175252
European journal of pharmacology 2022 Oct 15;933:175252
AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway.
Sun H, Cai H, Xu C, Zhai H, Lux F, Xie Y, Feng L, Du L, Liu Y, Sun X, Wang Q, Song H, He N, Zhang M, Ji K, Wang J, Gu Y, Leduc G, Doussineau T, Wang Y, Liu Q, Tillement O
Journal of nanobiotechnology 2022 Oct 14;20(1):449
Journal of nanobiotechnology 2022 Oct 14;20(1):449
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Zhou W, Wu WH, Si ZL, Liu HL, Wang H, Jiang H, Liu YF, Alolga RN, Chen C, Liu SJ, Bian XY, Shan JJ, Li J, Tan NH, Zhang ZH
Nature communications 2022 Oct 14;13(1):6081
Nature communications 2022 Oct 14;13(1):6081
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Xiong L, Wu H, Zhong T, Luo F, Li Q, Li M, Fan Y
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Accelerated Bone Regeneration by an Astaxanthin-Modified Antioxidant Aerogel through Relieving Oxidative Stress via the NRF2 Signaling Pathway.
Guo J, Yang X, Chen J, Wang C, Kang Y, Jiang T, Chen M, Li W, Zhou C, Chen Z
ACS biomaterials science & engineering 2022 Oct 10;8(10):4524-4534
ACS biomaterials science & engineering 2022 Oct 10;8(10):4524-4534
Photoprotective Effects of Cannabidiol against Ultraviolet-B-Induced DNA Damage and Autophagy in Human Keratinocyte Cells and Mouse Skin Tissue.
Li Y, Hao D, Wei D, Xiao Y, Liu L, Li X, Wang L, Gan Y, Yan W, Ke B, Jiang X
Molecules (Basel, Switzerland) 2022 Oct 10;27(19)
Molecules (Basel, Switzerland) 2022 Oct 10;27(19)
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Liu F, Wang Y, Chen L, Bello BK, Zhang T, Yang H, Li X, Pan E, Feng H, Dong J
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis.
Sun Y, He Y, Tong J, Liu D, Zhang H, He T, Bi Y
Genes & diseases 2022 Nov;9(6):1742-1756
Genes & diseases 2022 Nov;9(6):1742-1756
Betaine Ameliorates Acute Sever Ulcerative Colitis by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis.
Chen L, Liu D, Mao M, Liu W, Wang Y, Liang Y, Cao W, Zhong X
Molecular nutrition & food research 2022 Nov;66(22):e2200341
Molecular nutrition & food research 2022 Nov;66(22):e2200341
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.
Fang J, Ma Y, Li Y, Li J, Zhang X, Han X, Ma S, Guan F
Molecular carcinogenesis 2022 Nov;61(11):1043-1055
Molecular carcinogenesis 2022 Nov;61(11):1043-1055
Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.
Sun W, Xie W, Huang D, Cui Y, Yue J, He Q, Jiang L, Xiong J, Sun W, Yi Q
International journal of molecular medicine 2022 Nov;50(5)
International journal of molecular medicine 2022 Nov;50(5)
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Wang T, Liu J, Huang X, Zhang C, Shangguan M, Chen J, Wu S, Chen M, Yang Z, Zhao S
Oncology reports 2022 Nov;48(5)
Oncology reports 2022 Nov;48(5)
Realgar-induced nephrotoxicity via ferroptosis in mice.
Zhang S, Cao S, Zhou H, Li L, Hu Q, Mao X, Ji S
Journal of applied toxicology : JAT 2022 Nov;42(11):1843-1853
Journal of applied toxicology : JAT 2022 Nov;42(11):1843-1853
OL-FS13 alleviates experimental cerebral ischemia-reperfusion injury.
Liu N, Li Y, Yang Y, Shu L, Liu Y, Wu Y, Sun D, Kang Z, Zhang Y, Ni D, Wei Z, Li S, Yang M, Wang Y, Sun J, Yang X
Experimental neurology 2022 Nov;357:114180
Experimental neurology 2022 Nov;357:114180
Protective role of TLR9-induced macrophage/microglia phagocytosis after experimental intracerebral hemorrhage in mice.
Wei J, Dai S, Pu C, Luo P, Yang Y, Jiang X, Li X, Lin W, Fei Z
CNS neuroscience & therapeutics 2022 Nov;28(11):1800-1813
CNS neuroscience & therapeutics 2022 Nov;28(11):1800-1813
Xiaojianzhong decoction attenuates gastric mucosal injury by activating the p62/Keap1/Nrf2 signaling pathway to inhibit ferroptosis.
Chen J, Zhang J, Chen T, Bao S, Li J, Wei H, Hu X, Liang Y, Liu F, Yan S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113631
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113631
Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H(2)O(2)-induced BV-2 microglial cells injury.
Wang Y, Zhu M, Liang J, Zhang N, Sun D, Li H, Chen L
Bioorganic chemistry 2022 Nov;128:106067
Bioorganic chemistry 2022 Nov;128:106067
Magnesium isoglycyrrhizinate ameliorates lipopolysaccharide-induced liver injury by upregulating autophagy and inhibiting inflammation via IL-22 expression.
Zhou X, Li X, Yi K, Liang C, Geng S, Zhu J, Xie C, Zhong C
Bioorganic chemistry 2022 Nov;128:106034
Bioorganic chemistry 2022 Nov;128:106034
Spatial Analysis of NQO1 in Non-Small Cell Lung Cancer Shows Its Expression Is Independent of NRF1 and NRF2 in the Tumor Microenvironment.
Kaghazchi B, Um IH, Elshani M, Read OJ, Harrison DJ
Biomolecules 2022 Nov 8;12(11)
Biomolecules 2022 Nov 8;12(11)
5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages.
Liang P, Wang L, Yang S, Pan X, Li J, Zhang Y, Liang Y, Li J, Zhou B
Journal of inflammation (London, England) 2022 Nov 30;19(1):24
Journal of inflammation (London, England) 2022 Nov 30;19(1):24
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.
Jin Y, Zhang Q, Qin X, Liu Z, Li Z, Zhong X, Xia L, He J, Fang B
Journal of nanobiotechnology 2022 Nov 3;20(1):469
Journal of nanobiotechnology 2022 Nov 3;20(1):469
Neutrophil Nanovesicle Protects against Experimental Autoimmune Encephalomyelitis through Enhancing Myelin Clearance by Microglia.
Shen S, Cheng X, Zhou L, Zhao Y, Wang H, Zhang J, Sun X, Wang Y, Shu Y, Xu Y, Tao Y, Li M, Lu Z, Cai W, Nie G, Qiu W
ACS nano 2022 Nov 22;16(11):18886-18897
ACS nano 2022 Nov 22;16(11):18886-18897
Oxidative stress in the RVLM mediates sympathetic hyperactivity induced by circadian disruption.
Duan W, Ye P, Leng YQ, Liu DH, Sun JC, Tan X, Wang WZ
Neuroscience letters 2022 Nov 20;791:136917
Neuroscience letters 2022 Nov 20;791:136917
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
Li XT, Song JW, Zhang ZZ, Zhang MW, Liang LR, Miao R, Liu Y, Chen YH, Liu XY, Zhong JC
Free radical biology & medicine 2022 Nov 20;193(Pt 1):459-473
Free radical biology & medicine 2022 Nov 20;193(Pt 1):459-473
NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7.
Zhao X, Zhang M, Wang J, Ji K, Wang Y, Sun X, Xu C, Wang Q, He N, Song H, Du L, Wang F, Huang H, Liu Y, Liu Q
Free radical biology & medicine 2022 Nov 20;193(Pt 1):342-353
Free radical biology & medicine 2022 Nov 20;193(Pt 1):342-353
BP5 alleviates endotoxemia-induced acute lung injury by activating Nrf2 via dual regulation of the Keap1-Nrf2 interaction and the Akt (Ser473)/GSK3β (Ser9)/Fyn pathway.
Li T, Geng Z, Zhang J, Xu L, Zhu X
Free radical biology & medicine 2022 Nov 20;193(Pt 1):304-318
Free radical biology & medicine 2022 Nov 20;193(Pt 1):304-318
pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance "One Stone Four Birds" Effect of Rhein on Ulcerative Colitis.
Qi S, Luo R, Han X, Nie W, Ye N, Fu C, Gao F
ACS applied materials & interfaces 2022 Nov 16;14(45):50692-50709
ACS applied materials & interfaces 2022 Nov 16;14(45):50692-50709
Tea Tree Oil Mediates Antioxidant Factors Relish and Nrf2-Autophagy Axis Regulating the Lipid Metabolism of Macrobrachium rosenbergii.
Liu M, Zheng X, Sun C, Zhou Q, Liu B, Xu P
Antioxidants (Basel, Switzerland) 2022 Nov 16;11(11)
Antioxidants (Basel, Switzerland) 2022 Nov 16;11(11)
Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling.
Lu Q, Gouda NA, Quan G, Nada H, Elkamhawy A, Lee D, Lee CH, Cho J, Lee K
European journal of medicinal chemistry 2022 Nov 15;242:114692
European journal of medicinal chemistry 2022 Nov 15;242:114692
Salecan ameliorates liver injury by regulating gut microbiota and its metabolites.
Li P, Liu Y, Zhao J, Pan W, He Y, Fu S, Liu Y, Xu YJ
Food & function 2022 Nov 14;13(22):11744-11757
Food & function 2022 Nov 14;13(22):11744-11757
Antioxidant Effects of Roasted Licorice in a Zebrafish Model and Its Mechanisms.
Zhou Q, Zhang S, Geng X, Jiang H, Dai Y, Wang P, Hua M, Gao Q, Lang S, Hou L, Shi D, Zhou M
Molecules (Basel, Switzerland) 2022 Nov 10;27(22)
Molecules (Basel, Switzerland) 2022 Nov 10;27(22)
Silibinin improves L-cell mass and function through an estrogen receptor-mediated antioxidative mechanism.
Wang J, Zhang L, Cao H, Shi X, Zhang X, Gao Z, Ikeda K, Yan T, Jia Y, Xu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154022
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154022
LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1.
Sun Y, Teng Y, Wang L, Zhang Z, Chen C, Wang Y, Zhang X, Xiang P, Song X, Lu J, Li N, Gao L, Liang X, Xia Y, Wu Z, Ma C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 May;9(16):e2103135
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 May;9(16):e2103135
Collagen peptides from Acaudina molpadioides prevent CCl(4) -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.
Li J, Li Y, Lin S, Zhao W, Chen Y, Jin H
Journal of food science 2022 May;87(5):2185-2196
Journal of food science 2022 May;87(5):2185-2196
MCFA alleviate H(2) O(2) -induced oxidative stress in AML12 cells via the ERK1/2/Nrf2 pathway.
Wang D, Chen J, Sun H, Chen W, Yang X
Lipids 2022 May;57(3):153-162
Lipids 2022 May;57(3):153-162
Protective effect of rutin against diabetes-associated cognitive decline in rats.
Xianchu L, Huan P, Kang L, Beiwang D, Ming L
Pakistan journal of pharmaceutical sciences 2022 May;35(3):769-775
Pakistan journal of pharmaceutical sciences 2022 May;35(3):769-775
Manganese Mitigates Heat Stress-Induced Apoptosis by Alleviating Endoplasmic Reticulum Stress and Activating the NRF2/SOD2 Pathway in Primary Chick Embryonic Myocardial Cells.
Qin S, Wang R, Tang D, Qin S, Guo Y, Shi Z
Biological trace element research 2022 May;200(5):2312-2320
Biological trace element research 2022 May;200(5):2312-2320
Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2.
Sun X, Dong M, Gao Y, Wang Y, Du L, Liu Y, Wang Q, Ji K, He N, Wang J, Zhang M, Gu Y, Song H, Zhai H, Feng L, Xu C, Liu Q
Biochemical pharmacology 2022 May;199:114981
Biochemical pharmacology 2022 May;199:114981
Rhein regulates redox-mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage-activated crosstalk.
Zhou Y, Gao C, Vong CT, Tao H, Li H, Wang S, Wang Y
British journal of pharmacology 2022 May;179(9):1978-1997
British journal of pharmacology 2022 May;179(9):1978-1997
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6.
Zhou S, Li J, Zhang X, Xiong W
Bioengineered 2022 May;13(5):13507-13519
Bioengineered 2022 May;13(5):13507-13519
Novel 18β-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity.
Tu B, Liang J, Ou Y, Zhang X, Zheng W, Wu R, Gan L, Li D, Lu Y, Wu J, David Hong W, Zhang K, Wu P, Jin J, Wong WL
Bioorganic chemistry 2022 May;122:105714
Bioorganic chemistry 2022 May;122:105714
Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury.
Zheng J, Wang Y, Wang Z, Chen W, Luo M, Zhang C, Wang Y, Chen L, Wu F, Yang W, Yang Z, Wang Y, Shi C
Free radical research 2022 May-Jun;56(5-6):411-426
Free radical research 2022 May-Jun;56(5-6):411-426
Nrf2 Transcriptional Activity Governs Intestine Development.
Kopacz A, Kloska D, Klimczyk D, Kopec M, Jozkowicz A, Piechota-Polanczyk A
International journal of molecular sciences 2022 May 31;23(11)
International journal of molecular sciences 2022 May 31;23(11)
A transcriptomics and molecular biology based investigation reveals the protective effect and mechanism of carnosol on t-BHP induced HRMECs via Nrf2 signaling pathway.
Ren Y, Liu Y, Liu K, Shu Z, Lv T, Chen Z, Feng W, Zhang Y
European journal of pharmacology 2022 May 15;923:174933
European journal of pharmacology 2022 May 15;923:174933
Nrf2 and NF-κB/NLRP3 inflammasome pathways are involved in Prototheca bovis infections of mouse mammary gland tissue and mammary epithelial cells.
Zhao W, Deng Z, Barkema HW, Xu M, Gao J, Liu G, Lin Y, Kastelic JP, Han B
Free radical biology & medicine 2022 May 1;184:148-157
Free radical biology & medicine 2022 May 1;184:148-157
Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPARγ pathways in H9c2 cardiomyocytes.
Xiong L, Huang J, Wang S, Yuan Q, Yang D, Zheng Z, Wu Y, Wu C, Gao Y, Zou L, Hu G
Archives of toxicology 2022 Mar;96(3):767-781
Archives of toxicology 2022 Mar;96(3):767-781
Photothermal therapy with regulated Nrf2/NF-κB signaling pathway for treating bacteria-induced periodontitis.
Tian Y, Li Y, Liu J, Lin Y, Jiao J, Chen B, Wang W, Wu S, Li C
Bioactive materials 2022 Mar;9:428-445
Bioactive materials 2022 Mar;9:428-445
Identification of inflammatory response and alternative splicing in acute kidney injury and experimental verification of the involvement of RNA‑binding protein RBFOX1 in this disease.
Lin F, Xu L, Yuan R, Han S, Xie J, Jiang K, Li B, Yu W, Rao T, Zhou X, Cheng F
International journal of molecular medicine 2022 Mar;49(3)
International journal of molecular medicine 2022 Mar;49(3)
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Kang H, Dong Y, Peng R, Liu H, Guo Q, Song K, Zhu M, Yu K, Wu W, Li F
Biochemical pharmacology 2022 Mar;197:114932
Biochemical pharmacology 2022 Mar;197:114932
Protective effect of resveratrol against hydrogen peroxide-induced oxidative stress in bovine skeletal muscle cells.
Zhang X, Liu X, Wan F, You W, Tan X, Sheng Q, Li C, Hu Z, Liu G, Zhao H
Meat science 2022 Mar;185:108724
Meat science 2022 Mar;185:108724
Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling.
Zhang Z, Tang J, Song J, Xie M, Liu Y, Dong Z, Liu X, Li X, Zhang M, Chen Y, Shi H, Zhong J
Free radical biology & medicine 2022 Mar;181:130-142
Free radical biology & medicine 2022 Mar;181:130-142
Klotho alleviates NLRP3 inflammasome-mediated neuroinflammation in a temporal lobe epilepsy rat model by activating the Nrf2 signaling pathway.
Xiang T, Luo X, Ye L, Huang H, Wu Y
Epilepsy & behavior : E&B 2022 Mar;128:108509
Epilepsy & behavior : E&B 2022 Mar;128:108509
Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
Zhang W, Dun Y, You B, Qiu L, Ripley-Gonzalez JW, Cheng J, Fu S, Li C, Liu S
BMJ open diabetes research & care 2022 Mar;10(2)
BMJ open diabetes research & care 2022 Mar;10(2)
Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway.
Ding XQ, Jian TY, Gai YN, Niu GT, Liu Y, Meng XH, Li J, Lyu H, Ren BR, Chen J
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2923-2935
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2923-2935
DHA-Enriched Phospholipids and EPA-Enriched Phospholipids Alleviate Lipopolysaccharide-Induced Intestinal Barrier Injury in Mice via a Sirtuin 1-Dependent Mechanism.
Du L, Hao YM, Yang YH, Zheng Y, Wu ZJ, Zhou MQ, Wang BZ, Wang YM, Wu H, Su GH
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2911-2922
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2911-2922
Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells.
Jo A, Bae JH, Yoon YJ, Chung TH, Lee EW, Kim YH, Joh HM, Chung JW
Cell death & disease 2022 Mar 7;13(3):212
Cell death & disease 2022 Mar 7;13(3):212
Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents.
Fang Y, Tan Q, Zhou H, Gu Q, Xu J
European journal of medicinal chemistry 2022 Mar 5;231:114151
European journal of medicinal chemistry 2022 Mar 5;231:114151
Novel Prenylated Indole Alkaloids with Neuroprotection on SH-SY5Y Cells against Oxidative Stress Targeting Keap1-Nrf2.
Xiao X, Tong Z, Zhang Y, Zhou H, Luo M, Hu T, Hu P, Kong L, Liu Z, Yu C, Huang Z, Hu L
Marine drugs 2022 Mar 4;20(3)
Marine drugs 2022 Mar 4;20(3)
Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration.
Xu Z, Liu Y, Ma R, Chen J, Qiu J, Du S, Li C, Wu Z, Yang X, Chen Z, Chen T
ACS applied materials & interfaces 2022 Mar 30;14(12):14059-14071
ACS applied materials & interfaces 2022 Mar 30;14(12):14059-14071
Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway.
Ye J, Zheng J, Tian X, Xu B, Yuan F, Wang B, Yang Z, Huang F
Marine drugs 2022 Mar 25;20(4)
Marine drugs 2022 Mar 25;20(4)
Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome.
Dai Z, An LY, Chen XY, Yang F, Zhao N, Li CC, Ren R, Li BY, Tao WY, Li P, Jiang C, Yan F, Jiang ZY, You QD, Di B, Xu LL
Journal of medicinal chemistry 2022 Mar 24;65(6):5029-5043
Journal of medicinal chemistry 2022 Mar 24;65(6):5029-5043
Obstructive Sleep Apnea Affects Lacrimal Gland Function.
Wang S, He X, Li Q, Zhang Y, Hu J, Zong R, Zhuang J, Quantock AJ, Gao Y, Li W, Liu Z
Investigative ophthalmology & visual science 2022 Mar 2;63(3):3
Investigative ophthalmology & visual science 2022 Mar 2;63(3):3
Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses.
Li J, Deng SH, Li J, Li L, Zhang F, Zou Y, Wu DM, Xu Y
Cellular & molecular biology letters 2022 Mar 19;27(1):29
Cellular & molecular biology letters 2022 Mar 19;27(1):29
Hepatic Lipid Accumulation and Dysregulation Associate with Enhanced Reactive Oxygen Species and Pro-Inflammatory Cytokine in Low-Birth-Weight Goats.
Liu T, Li R, Luo N, Lou P, Limesand SW, Yang Y, Zhao Y, Chen X
Animals : an open access journal from MDPI 2022 Mar 18;12(6)
Animals : an open access journal from MDPI 2022 Mar 18;12(6)
Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.
Fu F, Lai Q, Hu J, Zhang L, Zhu X, Kou J, Yu B, Li F
Antioxidants (Basel, Switzerland) 2022 Mar 18;11(3)
Antioxidants (Basel, Switzerland) 2022 Mar 18;11(3)
Potential for reversing miR-634-mediated cytoprotective processes to improve efficacy of chemotherapy against oral squamous cell carcinoma.
Tran PX, Inoue J, Harada H, Inazawa J
Molecular therapy oncolytics 2022 Mar 17;24:897-908
Molecular therapy oncolytics 2022 Mar 17;24:897-908
The Inflammatory Response in Human Keratinocytes Exposed to Cinnamaldehyde Is Regulated by Nrf2.
Vallion R, Hardonnière K, Bouredji A, Damiens MH, Deloménie C, Pallardy M, Ferret PJ, Kerdine-Römer S
Antioxidants (Basel, Switzerland) 2022 Mar 17;11(3)
Antioxidants (Basel, Switzerland) 2022 Mar 17;11(3)
Centrosomal protein 290 is a novel prognostic indicator that modulates liver cancer cell ferroptosis via the Nrf2 pathway.
Shan Y, Yang G, Lu Q, Hu X, Qi D, Zhou Y, Xiao Y, Cao L, Tian F, Pan Q
Aging 2022 Mar 10;14(5):2367-2382
Aging 2022 Mar 10;14(5):2367-2382
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
Xu F, Zhang J, Zhou X, Hao H
Experimental cell research 2022 Mar 1;412(1):113025
Experimental cell research 2022 Mar 1;412(1):113025
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
Chen Z, Tian L, Wang L, Ma X, Lei F, Chen X, Fu R
Inflammation 2022 Jun;45(3):992-1006
Inflammation 2022 Jun;45(3):992-1006
Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment.
Wang L, Zhao L, Gong FL, Sun C, Du DD, Yang XX, Guo XL
Acta pharmacologica Sinica 2022 Jun;43(6):1556-1567
Acta pharmacologica Sinica 2022 Jun;43(6):1556-1567
Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.
Zhai X, Dai T, Chi Z, Zhao Z, Wu G, Yang S, Dong D
Environmental toxicology 2022 Jun;37(6):1332-1342
Environmental toxicology 2022 Jun;37(6):1332-1342
HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma.
Zeng Z, Huang H, Zhang J, Liu Y, Zhong W, Chen W, Lu Y, Qiao Y, Zhao H, Meng X, Zou F, Cai S, Dong H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jun;36(6):e22359
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jun;36(6):e22359
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
Cheng L, Shi L, He C, Wang C, Lv Y, Li H, An Y, Dai H, Duan Y, Zhang H, Huang Y, Fu W, Meng Y, Zhao B
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation in vitro.
Zhang Y, Zhou YJ, Tang JS, Lan JQ, Kang YY, Wu L, Peng Y
Journal of Asian natural products research 2022 Jun;24(6):577-588
Journal of Asian natural products research 2022 Jun;24(6):577-588
Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative response.
Zhu L, He S, Huang L, Ren D, Nie T, Tao K, Xia L, Lu F, Mao Z, Yang Q
Aging cell 2022 Jun;21(6):e13616
Aging cell 2022 Jun;21(6):e13616
Antagonistic effects of selenium on lead-induced oxidative stress and apoptosis of Leydig cells in sheep.
Shi L, Wang X, Duan Y, Li K, Ren Y
Theriogenology 2022 Jun;185:43-49
Theriogenology 2022 Jun;185:43-49
m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Liang D, Lin WJ, Ren M, Qiu J, Yang C, Wang X, Li N, Zeng T, Sun K, You L, Yan L, Wang W
Autophagy 2022 Jun;18(6):1318-1337
Autophagy 2022 Jun;18(6):1318-1337
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.
Li S, Ma Y, Ye S, Su Y, Hu D, Xiao F
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113071
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113071
Bioinspired Multifunctional Black Phosphorus Hydrogel with Antibacterial and Antioxidant Properties: A Stepwise Countermeasure for Diabetic Skin Wound Healing.
Ding Q, Sun T, Su W, Jing X, Ye B, Su Y, Zeng L, Qu Y, Yang X, Wu Y, Luo Z, Guo X
Advanced healthcare materials 2022 Jun;11(12):e2102791
Advanced healthcare materials 2022 Jun;11(12):e2102791
6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-κB pathway in H9c2 cells.
Han X, Liu P, Zheng B, Zhang M, Zhang Y, Xue Y, Liu C, Chu X, Wang X, Sun S, Chu L
The Journal of nutritional biochemistry 2022 Jun;104:108975
The Journal of nutritional biochemistry 2022 Jun;104:108975
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
Zhong T, Li M, Wu H, Wang D, Liu J, Xu Y, Fan Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.
Liu P, Lin C, Liu Z, Zhu C, Lin Z, Xu D, Chen J, Huang Q, Li CY, Hou L, Pan JA, Liu X
Cellular and molecular life sciences : CMLS 2022 Jun 8;79(7):352
Cellular and molecular life sciences : CMLS 2022 Jun 8;79(7):352
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Yin BF, Li ZL, Yan ZQ, Guo Z, Liang JW, Wang Q, Zhao ZD, Li PL, Hao RC, Han MY, Li XT, Mao N, Ding L, Chen DF, Gao Y, Zhu H
Stem cell research & therapy 2022 Jun 7;13(1):241
Stem cell research & therapy 2022 Jun 7;13(1):241
Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice.
Fan K, Zan X, Zhi Y, Yang Y, Hu K, Zhang X, Zhang X, Zhao S, Chen K, Gong X, Tian R, Zhang L
Biochemical and biophysical research communications 2022 Jun 4;607:103-109
Biochemical and biophysical research communications 2022 Jun 4;607:103-109
Protective Effect of Lycium ruthenicum Polyphenols on Oxidative Stress against Acrylamide Induced Liver Injury in Rats.
Gao H, Xue Y, Wu L, Huo J, Pang Y, Chen J, Gao Q
Molecules (Basel, Switzerland) 2022 Jun 25;27(13)
Molecules (Basel, Switzerland) 2022 Jun 25;27(13)
Novel Probiotic Lactic Acid Bacteria Were Identified from Healthy Infant Feces and Exhibited Anti-Inflammatory Capacities.
Li B, Pan LL, Sun J
Antioxidants (Basel, Switzerland) 2022 Jun 24;11(7)
Antioxidants (Basel, Switzerland) 2022 Jun 24;11(7)
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function.
Chen Z, Wang H, Hu B, Chen X, Zheng M, Liang L, Lyu J, Zeng Q
European journal of histochemistry : EJH 2022 Jun 21;66(3)
European journal of histochemistry : EJH 2022 Jun 21;66(3)
Constant light in early life induces fear-related behavior in chickens with suppressed melatonin secretion and disrupted hippocampal expression of clock- and BDNF-associated genes.
Yang Y, Cong W, Liu J, Zhao M, Xu P, Han W, Wang D, Zhao R
Journal of animal science and biotechnology 2022 Jun 21;13(1):67
Journal of animal science and biotechnology 2022 Jun 21;13(1):67
Mesenchymal stem cells improve redox homeostasis and mitochondrial respiration in fibroblast cell lines with pathogenic MT-ND3 and MT-ND6 variants.
Navaratnarajah T, Bellmann M, Seibt A, Anand R, Degistirici Ö, Meisel R, Mayatepek E, Reichert A, Baertling F, Distelmaier F
Stem cell research & therapy 2022 Jun 17;13(1):256
Stem cell research & therapy 2022 Jun 17;13(1):256
Inhibition of Nicotinamide adenine dinucleotide phosphate oxidase 4 attenuates cell apoptosis and oxidative stress in a rat model of polycystic ovary syndrome through the activation of Nrf-2/HO-1 signaling pathway.
Li Y, Xu J, Li L, Bai L, Wang Y, Zhang J, Wang H
Molecular and cellular endocrinology 2022 Jun 15;550:111645
Molecular and cellular endocrinology 2022 Jun 15;550:111645
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Zhou X, Wang S, Zhou R, Zhang T, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Zhou X, Song N
Toxicology 2022 Jun 15;475:153227
Toxicology 2022 Jun 15;475:153227
Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and ferroptosis in male reproduction of mice and TM4 Sertoli cells exposed to PM(2.5).
Shi F, Zhang Z, Cui H, Wang J, Wang Y, Tang Y, Yang W, Zou P, Ling X, Han F, Liu J, Chen Q, Liu C, Cao J, Ao L
Ecotoxicology and environmental safety 2022 Jun 15;238:113569
Ecotoxicology and environmental safety 2022 Jun 15;238:113569
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.
Zhou M, Dai Y, Ma Y, Yan Y, Hua M, Gao Q, Geng X, Zhou Q
Molecules (Basel, Switzerland) 2022 Jun 14;27(12)
Molecules (Basel, Switzerland) 2022 Jun 14;27(12)
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Nguyen V, Zhang Y, Gao C, Cao X, Tian Y, Carver W, Kiaris H, Cui T, Tan W
Cells 2022 Jun 14;11(12)
Cells 2022 Jun 14;11(12)
Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles.
Li N, Du H, Mao L, Xu G, Zhang M, Fan Y, Dong X, Zheng L, Wang B, Qin X, Jiang X, Chen C, Zou Z, Zhang J
Journal of nanobiotechnology 2022 Jun 11;20(1):270
Journal of nanobiotechnology 2022 Jun 11;20(1):270
Antioxidant potential of Pediococcus pentosaceus strains from the sow milk bacterial collection in weaned piglets.
Wang L, Liu Q, Chen Y, Zheng X, Wang C, Qi Y, Dong Y, Xiao Y, Chen C, Chen T, Huang Q, Zhai Z, Long C, Yang H, Li J, Wang L, Zhang G, Liao P, Liu YX, Huang P, Huang J, Wang Q, Chu H, Yin J, Yin Y
Microbiome 2022 Jun 1;10(1):83
Microbiome 2022 Jun 1;10(1):83
Structure of the nutrient-sensing hub GATOR2.
Valenstein ML, Rogala KB, Lalgudi PV, Brignole EJ, Gu X, Saxton RA, Chantranupong L, Kolibius J, Quast JP, Sabatini DM
Nature 2022 Jul;607(7919):610-616
Nature 2022 Jul;607(7919):610-616
Fibroblast growth factor 9 attenuates sepsis-induced fulminant hepatitis in mice.
Li A, Li XM, Song CG, Xiao X, Yao WM, Tian HS
Amino acids 2022 Jul;54(7):1069-1081
Amino acids 2022 Jul;54(7):1069-1081
CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy.
Dong J, Zhang KJ, Li GC, Chen XR, Lin JJ, Li JW, Lv ZY, Deng ZZ, Dai J, Cao W, Jiang Q
Acta pharmacologica Sinica 2022 Jul;43(7):1793-1802
Acta pharmacologica Sinica 2022 Jul;43(7):1793-1802
GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
Xu H, Jin J, Chen Y, Wu G, Zhu H, Wang Q, Wang J, Li S, Grigore FN, Ma J, Chen CC, Lan Q, Li M
Oncogene 2022 Jul;41(31):3876-3885
Oncogene 2022 Jul;41(31):3876-3885
Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma.
Li Y, Yang J, Zhang Q, Xu S, Sun W, Ge S, Xu X, Jager MJ, Jia R, Zhang J, Fan X
Oncogene 2022 Jul;41(27):3539-3553
Oncogene 2022 Jul;41(27):3539-3553
2-undecanone protects against fine particles-induced heart inflammation via modulating Nrf2/HO-1 and NF-κB pathways.
Jiao Y, Wang S, Jiang L, Sun X, Li J, Liu X, Yao X, Zhang C, Wang N, Deng H, Yang G
Environmental toxicology 2022 Jul;37(7):1642-1652
Environmental toxicology 2022 Jul;37(7):1642-1652
Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway.
Ma Y, Li S, Tang S, Ye S, Liang N, Liang Y, Xiao F
Environmental science and pollution research international 2022 Jul;29(34):52289-52301
Environmental science and pollution research international 2022 Jul;29(34):52289-52301
Enhanced Extracellular Matrix Degradation in Growth Plate Contributes to Manganese Deficiency-Induced Tibial Dyschondroplasia in Broiler Chicks.
Dong PF, Jin C, Lian CY, Wang L, Wang ZY
Biological trace element research 2022 Jul;200(7):3326-3335
Biological trace element research 2022 Jul;200(7):3326-3335
The neuroprotective effects of paeoniflorin against MPP(+)-induced damage to dopaminergic neurons via the Akt/Nrf2/GPX4 pathway.
Wang L, An H, Yu F, Yang J, Ding H, Bao Y, Xie H, Huang D
Journal of chemical neuroanatomy 2022 Jul;122:102103
Journal of chemical neuroanatomy 2022 Jul;122:102103
Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.
Luo P, Huang Q, Chen S, Wang Y, Dou H
International immunopharmacology 2022 Jul;108:108864
International immunopharmacology 2022 Jul;108:108864
Maackiain protects against sepsis via activating AMPK/Nrf2/HO-1 pathway.
Bai X, Zhu Y, Jie J, Li D, Song L, Luo J
International immunopharmacology 2022 Jul;108:108710
International immunopharmacology 2022 Jul;108:108710
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Zhu W, Tang H, Cao L, Zhang J, Li J, Ma D, Guo C
Chemical biology & drug design 2022 Jul;100(1):108-120
Chemical biology & drug design 2022 Jul;100(1):108-120
The Protective Effects of Apigenin Against Radiation-Induced Intestinal Injury.
Liu D, Peng R, Chen Z, Yu H, Wang S, Dong S, Li W, Shao W, Dai J, Li F, Jiang Q, Sun W
Dose-response : a publication of International Hormesis Society 2022 Jul-Sep;20(3):15593258221113791
Dose-response : a publication of International Hormesis Society 2022 Jul-Sep;20(3):15593258221113791
Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway.
Chen Z, Liu H, Zhao X, Mamateli S, Liu C, Wang L, Yu J, Liu Y, Cai J, Qiao T
BMC complementary medicine and therapies 2022 Jul 7;22(1):180
BMC complementary medicine and therapies 2022 Jul 7;22(1):180
Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway.
Huang Q, Zhang C, Dong S, Han J, Qu S, Xie T, Zhao H, Shi Y
Chinese medicine 2022 Jul 6;17(1):83
Chinese medicine 2022 Jul 6;17(1):83
Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ(1-42)-induced Alzheimer's disease mice and glutamate-injured HT22 cells.
Yang S, Xie Z, Pei T, Zeng Y, Xiong Q, Wei H, Wang Y, Cheng W
Chinese medicine 2022 Jul 4;17(1):82
Chinese medicine 2022 Jul 4;17(1):82
Lactoferrin Prevents Chronic Alcoholic Injury by Regulating Redox Balance and Lipid Metabolism in Female C57BL/6J Mice.
Li DM, Wu YX, Hu ZQ, Wang TC, Zhang LL, Zhou Y, Tong X, Xu JY, Qin LQ
Antioxidants (Basel, Switzerland) 2022 Jul 31;11(8)
Antioxidants (Basel, Switzerland) 2022 Jul 31;11(8)
Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway.
Dai C, Zhang Q, Shen L, Sharma G, Jiang H, Wang Z, Shen J
Antioxidants (Basel, Switzerland) 2022 Jul 30;11(8)
Antioxidants (Basel, Switzerland) 2022 Jul 30;11(8)
T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells.
Sun T, Zhang Q, Li M, Tang S, Dai C
Journal of fungi (Basel, Switzerland) 2022 Jul 22;8(8)
Journal of fungi (Basel, Switzerland) 2022 Jul 22;8(8)
Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats.
Liu R, Liu B, Tian L, Jiang X, Li X, Cai D, Sun J, Bai W, Jin Y
International journal of molecular sciences 2022 Jul 21;23(14)
International journal of molecular sciences 2022 Jul 21;23(14)
Antioxidant Effects of DPP-4 Inhibitors in Early Stages of Experimental Diabetic Retinopathy.
Ramos H, Bogdanov P, Huerta J, Deàs-Just A, Hernández C, Simó R
Antioxidants (Basel, Switzerland) 2022 Jul 21;11(7)
Antioxidants (Basel, Switzerland) 2022 Jul 21;11(7)
Bisdemethoxycurcumin Attenuated Renal Injury via Activation of Keap1/Nrf2 Pathway in High-Fat Diet-Fed Mice.
Ding X, Chen Y, Zhou L, Wu R, Jian T, Lyu H, Liu Y, Chen J
International journal of molecular sciences 2022 Jul 2;23(13)
International journal of molecular sciences 2022 Jul 2;23(13)
Oxidative injury induced by drinking water disinfection by-products dibromoacetonitrile and dichloroacetonitrile in mouse hippocampal neuronal cells: The protective effect of N-acetyl-L-cysteine.
Li F, Zhou J, Zhu X, Lu R, Ye Y, Wang S, Xing G, Shen H
Toxicology letters 2022 Jul 15;365:61-73
Toxicology letters 2022 Jul 15;365:61-73
Salvianolate ameliorates renal tubular injury through the Keap1/Nrf2/ARE pathway in mouse kidney ischemia-reperfusion injury.
Sun D, Cui S, Ma H, Zhu P, Li N, Zhang X, Zhang L, Xuan L, Li J
Journal of ethnopharmacology 2022 Jul 15;293:115331
Journal of ethnopharmacology 2022 Jul 15;293:115331
Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca(2+) release from the ER.
Inoue R, Tsuno T, Togashi Y, Okuyama T, Sato A, Nishiyama K, Kyohara M, Li J, Fukushima S, Kin T, Miyashita D, Shiba Y, Atobe Y, Kiyonari H, Bando K, Shapiro AMJ, Funakoshi K, Kulkarni RN, Terauchi Y, Shirakawa J
iScience 2022 Jul 15;25(7):104603
iScience 2022 Jul 15;25(7):104603
An auto-photoacoustic melanin-based drug delivery nano-platform for self-monitoring of acute kidney injury therapy via a triple-collaborative strategy.
Zhao X, Sun J, Dong J, Guo C, Cai W, Han J, Shen H, Lv S, Zhang R
Acta biomaterialia 2022 Jul 15;147:327-341
Acta biomaterialia 2022 Jul 15;147:327-341
Procyanidin B2 Alleviates Heat-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.
Wang H, Hao W, Yang L, Li T, Zhao C, Yan P, Wei S
International journal of molecular sciences 2022 Jul 14;23(14)
International journal of molecular sciences 2022 Jul 14;23(14)
GSTM3 deficiency impedes DNA mismatch repair to promote gastric tumorigenesis via CAND1/NRF2-KEAP1 signaling.
Chen T, Jinlin D, Wang F, Yuan Z, Xue J, Lu T, Huang W, Liu Y, Zhang Y
Cancer letters 2022 Jul 10;538:215692
Cancer letters 2022 Jul 10;538:215692
Angiotensin (1-7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats.
Zaman A, Banday AA
American journal of physiology. Renal physiology 2022 Jul 1;323(1):F33-F47
American journal of physiology. Renal physiology 2022 Jul 1;323(1):F33-F47
Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.
Yu G, Ji S, Yun Y, Cheng K, Zhang H, Jia P, Wang T, Zhang L
Journal of animal science 2022 Jul 1;100(7)
Journal of animal science 2022 Jul 1;100(7)
Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway.
Wen Y, Liu Y, Huang Q, Liu R, Liu J, Zhang F, Liu S, Jiang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153856
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153856
Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice.
Tang D, He WJ, Zhang ZT, Shi JJ, Wang X, Gu WT, Chen ZQ, Xu YH, Chen YB, Wang SM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153777
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153777
GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder.
Shimizu F, Ogawa R, Mizukami Y, Watanabe K, Hara K, Kadono C, Takahashi T, Misu T, Takeshita Y, Sano Y, Fujisawa M, Maeda T, Nakashima I, Fujihara K, Kanda T
Neurology(R) neuroimmunology & neuroinflammation 2022 Jan;9(1)
Neurology(R) neuroimmunology & neuroinflammation 2022 Jan;9(1)
Role of Nox4 in High Calcium-Induced Renal Oxidative Stress Damage and Crystal Deposition.
Xun Y, Zhou P, Yang Y, Li C, Zhang J, Hu H, Qin B, Zhang Z, Wang Q, Lu Y, Wang S
Antioxidants & redox signaling 2022 Jan;36(1-3):15-38
Antioxidants & redox signaling 2022 Jan;36(1-3):15-38
Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response.
Yang W, Tao K, Zhang P, Chen X, Sun X, Li R
Biochemical pharmacology 2022 Jan;195:114863
Biochemical pharmacology 2022 Jan;195:114863
Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.
Yang R, Zhang J, Li J, Qin R, Chen J, Wang R, Goltzman D, Miao D
Free radical biology & medicine 2022 Jan;178:246-261
Free radical biology & medicine 2022 Jan;178:246-261
Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice.
Fan H, Tu T, Zhang X, Yang Q, Liu G, Zhang T, Bao Y, Lu Y, Dong Z, Dong J, Zhao P
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112759
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112759
CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway.
Wang S, Yi X, Wu Z, Guo S, Dai W, Wang H, Shi Q, Zeng K, Guo W, Li C
The Journal of investigative dermatology 2022 Jan;142(1):189-200.e8
The Journal of investigative dermatology 2022 Jan;142(1):189-200.e8
Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner.
Han D, Li S, Xia Q, Meng X, Dong L
FEBS open bio 2022 Jan;12(1):118-129
FEBS open bio 2022 Jan;12(1):118-129
Genistein mitigates oxidative stress and inflammation by regulating Nrf2/HO-1 and NF-κB signaling pathways in hypoxic-ischemic brain damage in neonatal mice.
Li Y, Zhang JJ, Chen RJ, Chen L, Chen S, Yang XF, Min JW
Annals of translational medicine 2022 Jan;10(2):32
Annals of translational medicine 2022 Jan;10(2):32
Curcumin reduces oxidative stress and fat deposition in longissimus dorsi muscle of intrauterine growth-retarded finishing pigs.
Zhang J, Yan E, Zhang L, Wang T, Wang C
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13741
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13741
Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway.
Du P, Zhang X, Luo K, Li Y, Fu C, Xiao J, Xiao Q
Human & experimental toxicology 2022 Jan-Dec;41:9603271221087146
Human & experimental toxicology 2022 Jan-Dec;41:9603271221087146
Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats.
Sargin P, Roethle MF, Jia S, Pant T, Ciecko AE, Atkinson SN, Salzman NH, Teng RJ, Chen YG, Cabrera SM, Hessner MJ
Gut microbes 2022 Jan-Dec;14(1):2136467
Gut microbes 2022 Jan-Dec;14(1):2136467
Endothelial cell metabolic memory causes cardiovascular dysfunction in diabetes.
Yao Y, Song Q, Hu C, Da X, Yu Y, He Z, Xu C, Chen Q, Wang QK
Cardiovascular research 2022 Jan 7;118(1):196-211
Cardiovascular research 2022 Jan 7;118(1):196-211
Betulinic acid-nucleoside hybrid prevents acute alcohol -induced liver damage by promoting anti-oxidative stress and autophagy.
Zheng LY, Zou X, Wang YL, Zou M, Ma F, Wang N, Li JW, Wang MS, Hung HY, Wang Q
European journal of pharmacology 2022 Jan 5;914:174686
European journal of pharmacology 2022 Jan 5;914:174686
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Xu LT, Wang T, Fang KL, Zhao Y, Wang XN, Ren DM, Shen T
Journal of ethnopharmacology 2022 Jan 30;283:114694
Journal of ethnopharmacology 2022 Jan 30;283:114694
Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.
Liang R, Tong X, Dong Z, Qin W, Fan L, Bai Z, Zhang Z, Xiang T, Wang Z, Tan N
Journal of ethnopharmacology 2022 Jan 30;283:114664
Journal of ethnopharmacology 2022 Jan 30;283:114664
Hyperglycemia Induces Meibomian Gland Dysfunction.
Guo Y, Zhang H, Zhao Z, Luo X, Zhang M, Bu J, Liang M, Wu H, Yu J, He H, Zong R, Chen Y, Liu Z, Li W
Investigative ophthalmology & visual science 2022 Jan 3;63(1):30
Investigative ophthalmology & visual science 2022 Jan 3;63(1):30
Glyphosate-induced gut microbiota dysbiosis facilitates male reproductive toxicity in rats.
Liu JB, Chen K, Li ZF, Wang ZY, Wang L
The Science of the total environment 2022 Jan 20;805:150368
The Science of the total environment 2022 Jan 20;805:150368
Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects.
He ZX, An Q, Wei B, Zhou WJ, Wei BF, Gong YP, Zhang X, Gao G, Dong GJ, Huo JL, Zhang XH, Yang FF, Liu HM, Ma LY, Zhao W
Journal of medicinal chemistry 2022 Jan 13;65(1):163-190
Journal of medicinal chemistry 2022 Jan 13;65(1):163-190
Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo.
Wang G, Wang Y, Yang Q, Xu C, Zheng Y, Wang L, Wu J, Zeng M, Luo M
Cell death & disease 2022 Jan 10;13(1):29
Cell death & disease 2022 Jan 10;13(1):29
NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.
Feng Z, Qin Y, Huo F, Jian Z, Li X, Geng J, Li Y, Wu J
Biochimica et biophysica acta. Molecular basis of disease 2022 Jan 1;1868(1):166287
Biochimica et biophysica acta. Molecular basis of disease 2022 Jan 1;1868(1):166287
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Huang L, Han Y, Zhou Q, Sun Z, Yan J
Translational neuroscience 2022 Jan 1;13(1):301-308
Translational neuroscience 2022 Jan 1;13(1):301-308
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Liu YP, Yuan XY, Li XY, Wang Y, Sun ZB, Deng WH, Lei YD, Huang L, Jiang TY, Zhang ZH
Journal of applied toxicology : JAT 2022 Feb;42(2):230-243
Journal of applied toxicology : JAT 2022 Feb;42(2):230-243
Liraglutide Regulates Mitochondrial Quality Control System Through PGC-1α in a Mouse Model of Parkinson's Disease.
Wu P, Dong Y, Chen J, Guan T, Cao B, Zhang Y, Qi Y, Guan Z, Wang Y
Neurotoxicity research 2022 Feb;40(1):286-297
Neurotoxicity research 2022 Feb;40(1):286-297
Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
Kang H, Guo Q, Dong Y, Peng R, Song K, Wang J, Liu H, Zhu M, Zhao H, Guan H, Li F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Feb;36(2):e22167
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Feb;36(2):e22167
Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model.
Wang H, Li M, Chen P, Shi X
Reproductive sciences (Thousand Oaks, Calif.) 2022 Feb;29(2):578-585
Reproductive sciences (Thousand Oaks, Calif.) 2022 Feb;29(2):578-585
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance.
Romani P, Nirchio N, Arboit M, Barbieri V, Tosi A, Michielin F, Shibuya S, Benoist T, Wu D, Hindmarch CCT, Giomo M, Urciuolo A, Giamogante F, Roveri A, Chakravarty P, Montagner M, Calì T, Elvassore N, Archer SL, De Coppi P, Rosato A, Martello G, Dupont S
Nature cell biology 2022 Feb;24(2):168-180
Nature cell biology 2022 Feb;24(2):168-180
Dietary mulberry-leaf flavonoids improve the eggshell quality of aged breeder hens.
Huang Z, Dai H, Jiang J, Ye N, Zhu S, Wei Q, Lv Z, Shi F
Theriogenology 2022 Feb;179:177-186
Theriogenology 2022 Feb;179:177-186
Emodin ameliorates antioxidant capacity and exerts neuroprotective effect via PKM2-mediated Nrf2 transactivation.
Ding Z, Da HH, Osama A, Xi J, Hou Y, Fang J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Feb;160:112790
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Feb;160:112790
Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.
Zhong CC, Zhao T, Hogstrand C, Chen F, Song CC, Luo Z
The Journal of nutritional biochemistry 2022 Feb;100:108883
The Journal of nutritional biochemistry 2022 Feb;100:108883
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway.
Dang R, Wang M, Li X, Wang H, Liu L, Wu Q, Zhao J, Ji P, Zhong L, Licinio J, Xie P
Journal of neuroinflammation 2022 Feb 7;19(1):41
Journal of neuroinflammation 2022 Feb 7;19(1):41
Pharmacological Effects of Gami-Yukmijihwang-Tang on the Lipopolysaccharide-Induced Hippocampus Oxidation and Inflammation via Regulation of Sirt6.
Kang JY, Lee JS, Seol IC, Kim YS, Park MS, Yoo HR
Pharmaceuticals (Basel, Switzerland) 2022 Feb 28;15(3)
Pharmaceuticals (Basel, Switzerland) 2022 Feb 28;15(3)
Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway.
Liu B, Wang Z, He R, Xiong R, Li G, Zhang L, Fu T, Li C, Li N, Geng Q
Clinical science (London, England : 1979) 2022 Feb 25;136(4):273-289
Clinical science (London, England : 1979) 2022 Feb 25;136(4):273-289
The dual role of p62 in ferroptosis of glioblastoma according to p53 status.
Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Deng G, Xu Z, Zhang S, Liu B, Chen Q
Cell & bioscience 2022 Feb 25;12(1):20
Cell & bioscience 2022 Feb 25;12(1):20
18β-Glycyrrhetinic acid suppresses allergic airway inflammation through NF-κB and Nrf2/HO-1 signaling pathways in asthma mice.
Liu J, Xu Y, Yan M, Yu Y, Guo Y
Scientific reports 2022 Feb 24;12(1):3121
Scientific reports 2022 Feb 24;12(1):3121
Hydroxytyrosol Alleviates Dextran Sulfate Sodium-Induced Colitis by Modulating Inflammatory Responses, Intestinal Barrier, and Microbiome.
Wang Q, Wang C, Abdullah, Tian W, Qiu Z, Song M, Cao Y, Xiao J
Journal of agricultural and food chemistry 2022 Feb 23;70(7):2241-2252
Journal of agricultural and food chemistry 2022 Feb 23;70(7):2241-2252
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Liu H, Zhao D, Li H, Zhang W, Lin Q, Wang X, Zheng S, Zhang L, Li L, Hu S, Hu Y
Cell death & disease 2022 Feb 21;13(2):166
Cell death & disease 2022 Feb 21;13(2):166
Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway.
Chen GH, Song CC, Pantopoulos K, Wei XL, Zheng H, Luo Z
Free radical biology & medicine 2022 Feb 20;180:95-107
Free radical biology & medicine 2022 Feb 20;180:95-107
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
Zhang L, Zhu XZ, Badamjav R, Zhang JZ, Kou JP, Yu BY, Li F
European journal of pharmacology 2022 Feb 15;917:174748
European journal of pharmacology 2022 Feb 15;917:174748
Mitochondria-Dependent Oxidative Stress Mediates ZnO Nanoparticle (ZnO NP)-Induced Mitophagy and Lipotoxicity in Freshwater Teleost Fish.
Chen GH, Song CC, Zhao T, Hogstrand C, Wei XL, Lv WH, Song YF, Luo Z
Environmental science & technology 2022 Feb 15;56(4):2407-2420
Environmental science & technology 2022 Feb 15;56(4):2407-2420
Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities.
Wang W, Xiong L, Li Y, Song Z, Sun D, Li H, Chen L
Bioorganic & medicinal chemistry 2022 Feb 15;56:116627
Bioorganic & medicinal chemistry 2022 Feb 15;56:116627
Anti-fatigue effect of hypericin in a chronic forced exercise mouse model.
Sun Y, Liang C, Zheng L, Liu L, Li Z, Yang G, Li Y
Journal of ethnopharmacology 2022 Feb 10;284:114767
Journal of ethnopharmacology 2022 Feb 10;284:114767
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Ni L, Xiao J, Zhang D, Shao Z, Huang C, Wang S, Wu Y, Tian N, Sun L, Wu A, Zhou Y, Wang X, Zhang X
Cell death & disease 2022 Feb 10;13(2):140
Cell death & disease 2022 Feb 10;13(2):140
Basic fibroblast growth factor protects against liver ischemia-reperfusion injury via the Nrf2/Hippo signaling pathway.
Chen X, Tong G, Chen S
Tissue & cell 2022 Dec;79:101921
Tissue & cell 2022 Dec;79:101921
Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway.
Li H, Yuan Y, Chen H, Dai H, Li J
Molecular metabolism 2022 Dec;66:101617
Molecular metabolism 2022 Dec;66:101617
A plant-derived natural photosynthetic system for improving cell anabolism.
Chen P, Liu X, Gu C, Zhong P, Song N, Li M, Dai Z, Fang X, Liu Z, Zhang J, Tang R, Fan S, Lin X
Nature 2022 Dec;612(7940):546-554
Nature 2022 Dec;612(7940):546-554
ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
Zhang J, Liu L, Zhang Y, Yuan Y, Miao Z, Lu K, Zhang X, Ni R, Zhang H, Zhao Y, Wang X
Redox biology 2022 Dec;58:102554
Redox biology 2022 Dec;58:102554
Bone marrow-derived mesenchymal stem cells ameliorate severe acute pancreatitis by inhibiting oxidative stress in rats.
Zhao D, Yu W, Xie W, Ma Z, Hu Z, Song Z
Molecular and cellular biochemistry 2022 Dec;477(12):2761-2771
Molecular and cellular biochemistry 2022 Dec;477(12):2761-2771
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.
Li F, Mao Q, Wang J, Zhang X, Lv X, Wu B, Yan T, Jia Y
Metabolic brain disease 2022 Dec;37(8):2965-2978
Metabolic brain disease 2022 Dec;37(8):2965-2978
Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice.
Mao Y, Lee E, Yang X, Bae EJ, Jeon R, Park BH
Journal of enzyme inhibition and medicinal chemistry 2022 Dec;37(1):2133-2146
Journal of enzyme inhibition and medicinal chemistry 2022 Dec;37(1):2133-2146
Antidiabetic drug metformin suppresses tumorigenesis through inhibition of mevalonate pathway enzyme HMGCS1.
Chen Y, Li M, Yang Y, Lu Y, Li X
The Journal of biological chemistry 2022 Dec;298(12):102678
The Journal of biological chemistry 2022 Dec;298(12):102678
Ferroptosis contributes to hypoxic-ischemic brain injury in neonatal rats: Role of the SIRT1/Nrf2/GPx4 signaling pathway.
Li C, Wu Z, Xue H, Gao Q, Zhang Y, Wang C, Zhao P
CNS neuroscience & therapeutics 2022 Dec;28(12):2268-2280
CNS neuroscience & therapeutics 2022 Dec;28(12):2268-2280
Nickel nanoparticles exert cytotoxic effects on trophoblast HTR-8/SVneo cells possibly via Nrf2/MAPK/caspase 3 pathway.
Li T, Li Z, Fu J, Tang C, Liu L, Xu J, Zhao J, Li Z
Environmental research 2022 Dec;215(Pt 2):114336
Environmental research 2022 Dec;215(Pt 2):114336
Spermidine Alleviates Intrauterine Hypoxia-Induced Offspring Newborn Myocardial Mitochondrial Damage in Rats by Inhibiting Oxidative Stress and Regulating Mitochondrial Quality Control.
Chai N, Zheng H, Zhang H, Li L, Yu X, Wang L, Bi X, Yang L, Niu T, Liu X, Zhao Y, Dong L
Iranian journal of pharmaceutical research : IJPR 2022 Dec;21(1):e133776
Iranian journal of pharmaceutical research : IJPR 2022 Dec;21(1):e133776
Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing.
Guan G, Zhang Q, Jiang Z, Liu J, Wan J, Jin P, Lv Q
Small (Weinheim an der Bergstrasse, Germany) 2022 Dec;18(51):e2203064
Small (Weinheim an der Bergstrasse, Germany) 2022 Dec;18(51):e2203064
Defective autophagy triggered by arterial cyclic stretch promotes neointimal hyperplasia in vein grafts via the p62/nrf2/slc7a11 signaling pathway.
Chen Y, Bao M, Liu JT, Bao H, Zhang SM, Lou Y, Qi YX
Journal of molecular and cellular cardiology 2022 Dec;173:101-114
Journal of molecular and cellular cardiology 2022 Dec;173:101-114
Epoxymicheliolide prevents dextran sulfate sodium-induced colitis in mice by inhibiting TAK1-NF-κB pathway and activating Keap1-NRF2 signaling in macrophages.
He J, Liu L, Liu X, Chen H, Liu K, Huang N, Wang Y
International immunopharmacology 2022 Dec;113(Pt A):109404
International immunopharmacology 2022 Dec;113(Pt A):109404
Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway.
Liu L, Shi Q, Wang K, Qian Y, Zhou L, Bellusci S, Chen C, Dong N
International immunopharmacology 2022 Dec;113(Pt A):109398
International immunopharmacology 2022 Dec;113(Pt A):109398
Cycloastragenol suppresses M1 and promotes M2 polarization in LPS-stimulated BV-2 cells and ischemic stroke mice.
Chen T, Li Z, Li S, Zou Y, Gao X, Shu S, Wang Z
International immunopharmacology 2022 Dec;113(Pt A):109290
International immunopharmacology 2022 Dec;113(Pt A):109290
Mefunidone ameliorates lipopolysaccharide-induced acute lung injury through inhibiting MAPK signaling pathway and enhancing Nrf2 pathway.
Yao TT, Zhang Y, He RL, Lv X, He YJ, Li MY, Han YY, Long LZ, Jiang GL, Cheng XY, Hu GY, Li QB, Tao LJ, Meng J
International immunopharmacology 2022 Dec;113(Pt A):109263
International immunopharmacology 2022 Dec;113(Pt A):109263
Gankyrin and TIGAR cooperatively accelerate glucose metabolism toward the PPP and TCA cycle in hepatocellular carcinoma.
Yang C, Cui XW, Ding ZW, Jiang TY, Feng XF, Pan YF, Lin YK, Shang TY, Wang Q, Pan J, Wang J, Wang HY, Dong LW
Cancer science 2022 Dec;113(12):4151-4164
Cancer science 2022 Dec;113(12):4151-4164
Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.
Zhang J, Zhang M, Zhang WH, Zhu QM, Huo XK, Sun CP, Ma XC, Xiao HT
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154380
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154380
Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury.
Zhang J, Zhang M, Zhang WH, Zhu QM, Ning J, Huo XK, Xiao HT, Sun CP
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154377
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154377
Probiotic-fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota.
Zhao W, Peng D, Li W, Chen S, Liu B, Huang P, Wu J, Du B, Li P
Journal of the science of food and agriculture 2022 Dec;102(15):6877-6888
Journal of the science of food and agriculture 2022 Dec;102(15):6877-6888
Sulforaphane Ameliorates Hepatic Lipid Metabolism via Modulating Lipophagy In Vivo and In Vitro.
Lei P, Hu Y, Gao P, Ding Q, Yan J, Zhao J, Li B, Shan Y
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15126-15133
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15126-15133
Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke.
Liu J, Shen D, Wei C, Wu W, Luo Z, Hu L, Xiao Z, Hu T, Sun Q, Wang X, Ding Y, Liu M, Pang M, Gai K, Ma Y, Tian Y, Yu Y, Wang P, Guan Y, Xu M, Yang F, Li Q
iScience 2022 Dec 22;25(12):105527
iScience 2022 Dec 22;25(12):105527
Dehydroeburicoic Acid, a Dual Inhibitor against Oxidative Stress in Alcoholic Liver Disease.
Cheng S, Kuang Y, Li G, Wu J, Ko CN, Wang W, Ma DL, Ye M, Leung CH
Pharmaceuticals (Basel, Switzerland) 2022 Dec 22;16(1)
Pharmaceuticals (Basel, Switzerland) 2022 Dec 22;16(1)
Trehalose prevents glyphosate-induced testicular damage in roosters via its antioxidative properties.
Chen K, Liu JB, Tie CZ, Wang L
Research in veterinary science 2022 Dec 20;152:314-322
Research in veterinary science 2022 Dec 20;152:314-322
Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo.
Shi K, Xiao Y, Dong Y, Wang D, Xie Y, Tu J, Xu K, Zhou Z, Cao G, Liu Y
International journal of molecular sciences 2022 Dec 17;23(24)
International journal of molecular sciences 2022 Dec 17;23(24)
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
Ye H, Ma Z, Liu L, Zhang T, Han Q, Xiang Z, Xia Y, Ke Y, Guan X, Shi Q, Ataullakhanov FI, Panteleev M
ChemMedChem 2022 Dec 16;17(24):e202200317
ChemMedChem 2022 Dec 16;17(24):e202200317
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence.
Shi Y, Zhao L, Wang J, Liu S, Zhang Y, Qin Q
European journal of pharmacology 2022 Dec 15;937:175364
European journal of pharmacology 2022 Dec 15;937:175364
G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes.
Li C, Yin Z, Xiao R, Huang B, Cui Y, Wang H, Xiang Y, Wang L, Lei L, Ye J, Li T, Zhong Y, Guo F, Xia Y, Fang P, Liang K
Genome biology 2022 Dec 15;23(1):259
Genome biology 2022 Dec 15;23(1):259
Autophagy inhibition and reactive oxygen species elimination by acetyl-CoA acetyltransferase 1 through fused in sarcoma protein to promote prostate cancer.
Guan J, Jiang X, Guo Y, Zhao W, Li J, Li Y, Cheng M, Fu L, Zhao Y, Li Q
BMC cancer 2022 Dec 14;22(1):1313
BMC cancer 2022 Dec 14;22(1):1313
Improvement in heat stress-induced multiple organ dysfunction and intestinal damage through protection of intestinal goblet cells from prostaglandin E1 analogue misoprostol.
Hii HP, Lo WZ, Fu YH, Chen MH, Shih CC, Tsao CM, Ka SM, Chiu YL, Wu CC, Shih CC
Life sciences 2022 Dec 1;310:121039
Life sciences 2022 Dec 1;310:121039
Puerarin alleviates cadmium-induced rat neurocyte injury by alleviating Nrf2-mediated oxidative stress and inhibiting mitochondrial unfolded protein response.
Zhang W, Xu M, Wen S, Wang L, Zhang K, Zhang C, Zou H, Gu J, Liu X, Bian J, Liu Z, Yuan Y
Ecotoxicology and environmental safety 2022 Dec 1;247:114239
Ecotoxicology and environmental safety 2022 Dec 1;247:114239
The Nrf2 inhibitor brusatol synergistically enhances the cytotoxic effect of lapatinib in HER2-positive cancers.
Tian Z, Yang Y, Wu H, Chen Y, Jia H, Zhu L, He R, Jin Y, Zhou B, Ge C, Sun Y, Yang Y
Heliyon 2022 Aug;8(8):e10410
Heliyon 2022 Aug;8(8):e10410
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway.
Yuan Z, Xiao-Wei L, Juan W, Xiu-Juan L, Nian-Yun Z, Lei S
Journal of physiology and biochemistry 2022 Aug;78(3):641-652
Journal of physiology and biochemistry 2022 Aug;78(3):641-652
TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway.
Liu C, Li Y, Wang X
Inflammation 2022 Aug;45(4):1520-1533
Inflammation 2022 Aug;45(4):1520-1533
The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1.
Gao M, Qi Z, Deng M, Huang H, Xu Z, Guo G, Jing J, Huang X, Xu M, Kloeber JA, Liu S, Huang J, Lou Z, Han J
Oncogene 2022 Aug;41(33):4018-4027
Oncogene 2022 Aug;41(33):4018-4027
MgIG exerts therapeutic effects on crizotinib-induced hepatotoxicity by limiting ROS-mediated autophagy and pyroptosis.
Li M, Wang C, Yu Z, Lan Q, Xu S, Ye Z, Li R, Ying L, Zhang X, Zhou Z
Journal of cellular and molecular medicine 2022 Aug;26(16):4492-4505
Journal of cellular and molecular medicine 2022 Aug;26(16):4492-4505
Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol-Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways.
Li QM, Yang XR, Zha XQ, Pan LH, Zang DD, Zhang FY, Luo JP
Chemistry & biodiversity 2022 Aug;19(8):e202200471
Chemistry & biodiversity 2022 Aug;19(8):e202200471
Nrf2 Activation and NF-Kb & caspase/bax signaling inhibition by sodium butyrate alleviates LPS-induced cell injury in bovine mammary epithelial cells.
Ali I, Li C, Kuang M, Shah AU, Shafiq M, Ahmad MA, Abdalmegeed D, Li L, Wang G
Molecular immunology 2022 Aug;148:54-67
Molecular immunology 2022 Aug;148:54-67
Activation of AMPK/p38/Nrf2 is involved in resveratrol alleviating myocardial ischemia-reperfusion injury in diabetic rats as an endogenous antioxidant stress feedback.
Xu G, Ma Y, Jin J, Wang X
Annals of translational medicine 2022 Aug;10(16):890
Annals of translational medicine 2022 Aug;10(16):890
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
Huang W, Wen F, Gu P, Liu J, Xia Y, Li Y, Zhou J, Song S, Ruan S, Gu S, Chen X, Shu P
Chinese medicine 2022 Aug 9;17(1):93
Chinese medicine 2022 Aug 9;17(1):93
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration.
Peng P, Wang D, Xu X, Wang D, Gao B, Wang H, Jia H, Shang Q, Zheng C, Gao C, Mao J, Luo Z, Yang L, Hu X
Arthritis research & therapy 2022 Aug 3;24(1):181
Arthritis research & therapy 2022 Aug 3;24(1):181
Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes.
Shi JZ, Zheng XM, Zhou YF, Yun LY, Luo DM, Hao JJ, Liu PF, Zhang WK, Xu JK, Yan Y, Xie XM, He YY, Pang XB
Nutrients 2022 Aug 3;14(15)
Nutrients 2022 Aug 3;14(15)
LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination.
Zhang B, Bao W, Zhang S, Chen B, Zhou X, Zhao J, Shi Z, Zhang T, Chen Z, Wang L, Zheng X, Chen G, Wang Y
Cell death & disease 2022 Aug 25;13(8):734
Cell death & disease 2022 Aug 25;13(8):734
Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells.
Zhang M, Qiu H, Mao L, Wang B, Li N, Fan Y, Weng P, Hu S, Dong X, Qin X, Chen C, Zou Z, Yu C, Zhang J
Cell death & disease 2022 Aug 25;13(8):733
Cell death & disease 2022 Aug 25;13(8):733
Design of Diselenide-Bridged Hyaluronic Acid Nano-antioxidant for Efficient ROS Scavenging to Relieve Colitis.
Xu J, Chu T, Yu T, Li N, Wang C, Li C, Zhang Y, Meng H, Nie G
ACS nano 2022 Aug 23;16(8):13037-13048
ACS nano 2022 Aug 23;16(8):13037-13048
Aucubin promotes bone-fracture healing via the dual effects of anti-oxidative damage and enhancing osteoblastogenesis of hBM-MSCs.
Wang K, Zhou C, Li L, Dai C, Wang Z, Zhang W, Xu J, Zhu Y, Pan Z
Stem cell research & therapy 2022 Aug 19;13(1):424
Stem cell research & therapy 2022 Aug 19;13(1):424
Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis.
Zhang Z, Ji C, Wang YN, Liu S, Wang M, Xu X, Zhang D
Cells 2022 Aug 17;11(16)
Cells 2022 Aug 17;11(16)
Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector.
Li R, Wilson KF, Cerione RA
Cell death discovery 2022 Aug 13;8(1):357
Cell death discovery 2022 Aug 13;8(1):357
ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression.
Grube J, Woitok MM, Mohs A, Erschfeld S, Lynen C, Trautwein C, Otto T
Cell death & disease 2022 Aug 13;13(8):704
Cell death & disease 2022 Aug 13;13(8):704
Cytoglobin Silencing Promotes Melanoma Malignancy but Sensitizes for Ferroptosis and Pyroptosis Therapy Response.
De Backer J, Maric D, Zuhra K, Bogaerts A, Szabo C, Vanden Berghe W, Hoogewijs D
Antioxidants (Basel, Switzerland) 2022 Aug 10;11(8)
Antioxidants (Basel, Switzerland) 2022 Aug 10;11(8)
Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.
Zhu J, Liu L, Ma J, Fu Q, Zheng Z, Du E, Xu Y, Zhang Z
Environmental pollution (Barking, Essex : 1987) 2022 Aug 1;306:119421
Environmental pollution (Barking, Essex : 1987) 2022 Aug 1;306:119421
4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury.
Peng X, Su S, Zeng J, Xie K, Yang X, Xian G, Xiao Z, Zhu P, Zheng S, Xu D, Zeng Q
Free radical biology & medicine 2022 Aug 1;188:404-418
Free radical biology & medicine 2022 Aug 1;188:404-418
Fermented noni (Morinda citrifolia L.) fruit juice improved oxidative stress and insulin resistance under the synergistic effect of Nrf2/ARE pathway and gut flora in db/db mice and HepG2 cells.
Zhang X, Zhang B, Li L, Li X, Zhang J, Chen G
Food & function 2022 Aug 1;13(15):8254-8273
Food & function 2022 Aug 1;13(15):8254-8273
Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.
Zhou W, Dong G, Gao G, He Z, Xu J, Aziz S, Ma L, Zhao W
Biochemistry and cell biology = Biochimie et biologie cellulaire 2022 Aug 1;100(4):309-324
Biochemistry and cell biology = Biochimie et biologie cellulaire 2022 Aug 1;100(4):309-324
Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways.
Shi Y, Chen J, Li S, Wu Y, Yu C, Ni L, Xiao J, Shao Z, Zhu H, Wang J, Wang X, Zhang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153928
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153928
Adipokine ZAG Alters Depression-Like Behavior by Regulating Oxidative Stress in Hippocampus.
Sun H, Ma F, Chen W, Yang X
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2022 Apr;54(4):259-267
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2022 Apr;54(4):259-267
The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.
Wu XY, Wang T, Hu HX, Zhang K, Zhao Y, Zhao BB, Lou HX, Wang XN, Shen T
Phytotherapy research : PTR 2022 Apr;36(4):1692-1707
Phytotherapy research : PTR 2022 Apr;36(4):1692-1707
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y, Wu Y, Tian N, Sun L, Wu A, Pan Z, Zhang X, Wang X
Biochemical pharmacology 2022 Apr;198:114935
Biochemical pharmacology 2022 Apr;198:114935
Sulforaphane improves cognitive dysfunction after surgery and anesthesia in mice: The role of Keap1-Nrf2 signaling.
Hua D, Luo A, Wu Z, Huang C, Li S, Xu X, Xu J, Yang C, Wang D, Liu C
Brain research bulletin 2022 Apr;181:1-11
Brain research bulletin 2022 Apr;181:1-11
Acute lung inflammation induced by zinc oxide nanoparticles: Evolution and intervention via NRF2 activator.
Guo T, Fang X, Liu Y, Ruan Y, Hu Y, Wang X, Hu Y, Wang G, Xu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Apr;162:112898
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Apr;162:112898
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Zhu W, Tang H, Li J, Guedes RM, Cao L, Guo C
Bioengineered 2022 Apr;13(4):9233-9247
Bioengineered 2022 Apr;13(4):9233-9247
Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension.
Sun Y, Wan W, Zhao X, Han X, Ye T, Chen X, Ran Q, Wang X, Liu X, Qu C, Shi S, Zhang C, Yang B
Bioengineered 2022 Apr;13(4):10843-10856
Bioengineered 2022 Apr;13(4):10843-10856
Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation.
Xue J, Liao Q, Luo M, Hua C, Zhao J, Yu G, Chen X, Li X, Zhang X, Ran R, Lu F, Wang Y, Qiao L
Open biology 2022 Apr;12(4):210310
Open biology 2022 Apr;12(4):210310
Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance.
Wang H, Wang Q, Cai G, Duan Z, Nugent Z, Huang J, Zheng J, Borowsky AD, Li JJ, Liu P, Kung HJ, Murphy L, Chen HW, Wang J
Acta pharmaceutica Sinica. B 2022 Apr;12(4):1871-1884
Acta pharmaceutica Sinica. B 2022 Apr;12(4):1871-1884
Melatonin Nuclear Receptors Mediate Green-and-Blue-Monochromatic-Light-Combinations-Inhibited B Lymphocyte Apoptosis in the Bursa of Chickens via Reducing Oxidative Stress and Nfκb Expression.
Zhang Y, Wang Z, Dong Y, Cao J, Chen Y
Antioxidants (Basel, Switzerland) 2022 Apr 8;11(4)
Antioxidants (Basel, Switzerland) 2022 Apr 8;11(4)
D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation.
Ueda E, Ohta T, Konno A, Hirai H, Kurauchi Y, Katsuki H, Seki T
Cells 2022 Apr 5;11(7)
Cells 2022 Apr 5;11(7)
Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway.
Jia Y, Guo H, Cheng X, Zhang Y, Si M, Shi J, Ma D
Food & function 2022 Apr 4;13(7):4205-4215
Food & function 2022 Apr 4;13(7):4205-4215
Relationship between Neuroprotective Effects and Structure of Procyanidins.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J
Molecules (Basel, Switzerland) 2022 Apr 2;27(7)
Molecules (Basel, Switzerland) 2022 Apr 2;27(7)
MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis.
Ma H, Xie C, Chen Z, He G, Dai Z, Cai H, Zhang H, Lu H, Wu H, Hu X, Zhou K, Zheng G, Xu H, Xu C
Cell death discovery 2022 Apr 19;8(1):209
Cell death discovery 2022 Apr 19;8(1):209
Activation of Nrf2/HO-1 Antioxidant Pathway by Heme Attenuates Calcification of Human Lens Epithelial Cells.
Chowdhury A, Balogh E, Ababneh H, Tóth A, Jeney V
Pharmaceuticals (Basel, Switzerland) 2022 Apr 19;15(5)
Pharmaceuticals (Basel, Switzerland) 2022 Apr 19;15(5)
Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.
Yan W, Li M, Guo Q, Li X, Zhou S, Dai J, Zhang J, Wu M, Tang W, Wen J, Xue L, Jin Y, Luo A, Wang S
Ecotoxicology and environmental safety 2022 Apr 15;235:113432
Ecotoxicology and environmental safety 2022 Apr 15;235:113432
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
Xi X, Li Z, Liu H, Chen S, Liu D
Frontiers in cell and developmental biology 2021;9:816000
Frontiers in cell and developmental biology 2021;9:816000
Notoginsenoside R1 Protects Against High Glucose-Induced Cell Injury Through AMPK/Nrf2 and Downstream HO-1 Signaling.
Du F, Huang H, Cao Y, Ran Y, Wu Q, Chen B
Frontiers in cell and developmental biology 2021;9:791643
Frontiers in cell and developmental biology 2021;9:791643
SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production.
Zhao X, Gao M, Liang J, Chen Y, Wang Y, Wang Y, Xiao Y, Zhao Z, Wan X, Jiang M, Luo X, Wang F, Sun X
Frontiers in cell and developmental biology 2021;9:639851
Frontiers in cell and developmental biology 2021;9:639851
Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway.
Liao ZQ, Jiang YN, Su ZL, Bi HL, Li JT, Li CL, Yang XL, Zhang Y, Xie X
Frontiers in cardiovascular medicine 2021;8:809689
Frontiers in cardiovascular medicine 2021;8:809689
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Zhang P, Han X, Zhang X, Zhu X
Frontiers in nutrition 2021;8:667695
Frontiers in nutrition 2021;8:667695
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Li X, Gao M, Zhu S, Yin L, Zhang B, Qi Y, Zhao Y, Yu Y, Xu L
Frontiers in nutrition 2021;8:635232
Frontiers in nutrition 2021;8:635232
Nicotinic Acid against Acetaminophen-Induced Hepatotoxicity via Sirt1/Nrf2 Antioxidative Pathway in Mice.
Hu D, Zhang L, Jiang R, Liao C, Xu J, Jiang S, Yang Y, Lin L, Huang J, Shen Y, Tang L, Li L
Journal of nutritional science and vitaminology 2021;67(3):145-152
Journal of nutritional science and vitaminology 2021;67(3):145-152
Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways.
Qiu R, Chen S, Hua F, Bian S, Chen J, Li G, Wu X
Biological & pharmaceutical bulletin 2021;44(9):1254-1262
Biological & pharmaceutical bulletin 2021;44(9):1254-1262
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Li Y, Chandra TP, Song X, Nie L, Liu M, Yi J, Zheng X, Chu C, Yang J
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Metabolic Activation of Retrorsine may Disrupt Bile Acid Homeostasis in Mice through the Nrf2 Pathway.
Pang X, Tang C, Cao P, Zhou L, Chen X
Current drug metabolism 2021;22(11):870-881
Current drug metabolism 2021;22(11):870-881
Nrf2 Activation Attenuates Chronic Constriction Injury-Induced Neuropathic Pain via Induction of PGC-1α-Mediated Mitochondrial Biogenesis in the Spinal Cord.
Sun J, Li JY, Zhang LQ, Li DY, Wu JY, Gao SJ, Liu DQ, Zhou YQ, Mei W
Oxidative medicine and cellular longevity 2021;2021:9577874
Oxidative medicine and cellular longevity 2021;2021:9577874
Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway.
Yang F, He X, Chen T, Liu J, Luo Z, Sun S, Qin D, Huang W, Tang Y, Liu C, Luo F
Oxidative medicine and cellular longevity 2021;2021:9426314
Oxidative medicine and cellular longevity 2021;2021:9426314
Zisheng Shenqi Decoction Ameliorates Monosodium Urate-Mediated Gouty Arthritis in Rats via Promotion of Autophagy through the AMPK/mTOR Signaling Pathway.
Han J, Shi G, Li W, Wang S, Bai J, Sun X, Xie Y, Sui F, Chen F, Jiang D
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6918026
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6918026
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
Zhang J, Cheng P, Dai W, Ji J, Wu L, Feng J, Wu J, Yu Q, Li J, Guo C
PPAR research 2021;2021:6658944
PPAR research 2021;2021:6658944
MCU That Is Transcriptionally Regulated by Nrf2 Augments Malignant Biological Behaviors in Oral Squamous Cell Carcinoma Cells.
Wu R, Zuo W, Xu X, Bi L, Zhang C, Chen H, Liu H
BioMed research international 2021;2021:6650791
BioMed research international 2021;2021:6650791
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.
Liu H, Xu X, Wu R, Bi L, Zhang C, Chen H, Yang Y
BioMed research international 2021;2021:6616547
BioMed research international 2021;2021:6616547
GPX4-Regulated Ferroptosis Mediates S100-Induced Experimental Autoimmune Hepatitis Associated with the Nrf2/HO-1 Signaling Pathway.
Zhu L, Chen D, Zhu Y, Pan T, Xia D, Cai T, Lin H, Lin J, Jin X, Wu F, Yu S, Zhu K, Xu L, Chen Y
Oxidative medicine and cellular longevity 2021;2021:6551069
Oxidative medicine and cellular longevity 2021;2021:6551069
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Lv D, Luo M, Cheng Z, Wang R, Yang X, Guo Y, Huang L, Li X, Huang B, Shen J, Luo S, Yan J
Oxidative medicine and cellular longevity 2021;2021:5577019
Oxidative medicine and cellular longevity 2021;2021:5577019
Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway.
Ding B, Geng S, Hou X, Ma X, Xu H, Yang F, Liu K, Liang W, Ma G
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5545193
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5545193
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Li X, Wang X, Miao L, Guo Y, Yuan R, Ren J, Huang Y, Tian H
Oxidative medicine and cellular longevity 2021;2021:4714649
Oxidative medicine and cellular longevity 2021;2021:4714649
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy.
Pei Z, Wang X, Yang C, Dong M, Wang F
Oxidative medicine and cellular longevity 2021;2021:3899356
Oxidative medicine and cellular longevity 2021;2021:3899356
Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes.
Yang B, Huang H, He Q, Lu W, Zheng L, Cui L
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1905995
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1905995
Microglia-Derived Exosomes Improve Spinal Cord Functional Recovery after Injury via Inhibiting Oxidative Stress and Promoting the Survival and Function of Endothelia Cells.
Peng W, Wan L, Luo Z, Xie Y, Liu Y, Huang T, Lu H, Hu J
Oxidative medicine and cellular longevity 2021;2021:1695087
Oxidative medicine and cellular longevity 2021;2021:1695087
PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa.
Zhu P, Yang Q, Li G, Chang Q
Disease markers 2021;2021:1602797
Disease markers 2021;2021:1602797
Gastric Electrical Pacing Reduces Apoptosis of Interstitial Cells of Cajal via Antioxidative Stress Effect Attributing to Phenotypic Polarization of M2 Macrophages in Diabetic Rats.
Wang H, Zhao K, Ba Y, Gao T, Shi N, Niu Q, Liu C, Chen Y
Oxidative medicine and cellular longevity 2021;2021:1298657
Oxidative medicine and cellular longevity 2021;2021:1298657
Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies.
Zou L, Cheng G, Xu C, Liu H, Wang Y, Li N, Fan X, Zhu C, Xia W
International journal of nanomedicine 2021;16:1565-1573
International journal of nanomedicine 2021;16:1565-1573
Acupuncture Relieves Stress-Induced Depressive Behavior by Reducing Oxidative Stress and Neuroapoptosis in Rats.
Cheng WJ, Li P, Huang WY, Huang Y, Chen WJ, Chen YP, Shen JL, Chen JK, Long NS, Meng XJ
Frontiers in behavioral neuroscience 2021;15:783056
Frontiers in behavioral neuroscience 2021;15:783056
Methylcobalamin Protects Melanocytes from H(2)O(2)-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway.
An R, Li D, Dong Y, She Q, Zhou T, Nie X, Pan R, Deng Y
Drug design, development and therapy 2021;15:4837-4848
Drug design, development and therapy 2021;15:4837-4848
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F
Drug design, development and therapy 2021;15:3207-3221
Drug design, development and therapy 2021;15:3207-3221
Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice.
Chen D, Gao ZQ, Wang YY, Wan BB, Liu G, Chen JL, Wu YX, Zhou Q, Jiang SY, Yu RQ, Pang QF
Journal of inflammation research 2021;14:803-816
Journal of inflammation research 2021;14:803-816
Computational Systems Pharmacology, Molecular Docking and Experiments Reveal the Protective Mechanism of Li-Da-Qian Mixture in the Treatment of Glomerulonephritis.
Zhou W, Sha Y, Zeng J, Zhang X, Zhang A, Ge X
Journal of inflammation research 2021;14:6939-6958
Journal of inflammation research 2021;14:6939-6958
Analysis by Metabolomics and Transcriptomics for the Energy Metabolism Disorder and the Aryl Hydrocarbon Receptor Activation in Male Reproduction of Mice and GC-2spd Cells Exposed to PM(2.5).
Shi F, Zhang Z, Wang J, Wang Y, Deng J, Zeng Y, Zou P, Ling X, Han F, Liu J, Ao L, Cao J
Frontiers in endocrinology 2021;12:807374
Frontiers in endocrinology 2021;12:807374
Limonin Alleviates Non-alcoholic Fatty Liver Disease by Reducing Lipid Accumulation, Suppressing Inflammation and Oxidative Stress.
Li Y, Yang M, Lin H, Yan W, Deng G, Ye H, Shi H, Wu C, Ma G, Xu S, Tan Q, Gao Z, Gao L
Frontiers in pharmacology 2021;12:801730
Frontiers in pharmacology 2021;12:801730
DPHC From Alpinia officinarum Ameliorates Oxidative Stress and Insulin Resistance via Activation of Nrf2/ARE Pathway in db/db Mice and High Glucose-Treated HepG2 Cells.
Zhang X, Zhang Y, Zhou M, Xie Y, Dong X, Bai F, Zhang J
Frontiers in pharmacology 2021;12:792977
Frontiers in pharmacology 2021;12:792977
Menthol Targeting AMPK Alleviates the Inflammatory Response of Bovine Mammary Epithelial Cells and Restores the Synthesis of Milk Fat and Milk Protein.
Liu S, Guo W, Jia Y, Ye B, Liu S, Fu S, Liu J, Hu G
Frontiers in immunology 2021;12:782989
Frontiers in immunology 2021;12:782989
Enhancing Fatty Acids Oxidation via L-Carnitine Attenuates Obesity-Related Atrial Fibrillation and Structural Remodeling by Activating AMPK Signaling and Alleviating Cardiac Lipotoxicity.
Zhang Y, Fu Y, Jiang T, Liu B, Sun H, Zhang Y, Fan B, Li X, Qin X, Zheng Q
Frontiers in pharmacology 2021;12:771940
Frontiers in pharmacology 2021;12:771940
Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice.
Jia Y, Li J, Liu P, Si M, Jin Y, Wang H, Ma D, Chu L
Frontiers in pharmacology 2021;12:758670
Frontiers in pharmacology 2021;12:758670
Induction of Mitosis Delay and Apoptosis by CDDO-TFEA in Glioblastoma Multiforme.
Tsai TH, Lieu AS, Huang TY, Kwan AL, Lin CL, Hsu YC
Frontiers in pharmacology 2021;12:756228
Frontiers in pharmacology 2021;12:756228
Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell.
Xiong H, Chen Z, Lin B, Xie B, Liu X, Chen C, Li Z, Jia Y, Wu Z, Yang M, Jia Y, Wang L, Zhou J, Meng X
Frontiers in immunology 2021;12:745111
Frontiers in immunology 2021;12:745111
Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival.
Jiang J, Dong C, Zhai L, Lou J, Jin J, Cheng S, Chen Z, Guo X, Lin D, Ding J, Gao W
Frontiers in pharmacology 2021;12:735530
Frontiers in pharmacology 2021;12:735530
Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway.
Wang J, Jiang W, Xin J, Xue W, Shi C, Wen J, Huang Y, Hu C
Frontiers in pharmacology 2021;12:717276
Frontiers in pharmacology 2021;12:717276
Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets.
Wang M, Huang H, Wang L, Yang H, He S, Liu F, Tu Q, He S
Frontiers in microbiology 2021;12:706758
Frontiers in microbiology 2021;12:706758
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Liu X, Xu Y, Cheng S, Zhou X, Zhou F, He P, Hu F, Zhang L, Chen Y, Jia Y
Frontiers in pharmacology 2021;12:687394
Frontiers in pharmacology 2021;12:687394
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Luo LF, Qin LY, Wang JX, Guan P, Wang N, Ji ES
Frontiers in pharmacology 2021;12:669782
Frontiers in pharmacology 2021;12:669782
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Zheng T, Yang J, Zhang J, Yang C, Fan Z, Li Q, Zhai Y, Liu H, Yang J
Frontiers in pharmacology 2021;12:669146
Frontiers in pharmacology 2021;12:669146
The Protective Effects of Sulforaphane on High-Fat Diet-Induced Obesity in Mice Through Browning of White Fat.
Liu Y, Fu X, Chen Z, Luo T, Zhu C, Ji Y, Bian Z
Frontiers in pharmacology 2021;12:665894
Frontiers in pharmacology 2021;12:665894
Tanshinone I Inhibits Oxidative Stress-Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling.
Wu YT, Xie LP, Hua Y, Xu HL, Chen GH, Han X, Tan ZB, Fan HJ, Chen HM, Li J, Liu B, Zhou YC
Frontiers in pharmacology 2021;12:644116
Frontiers in pharmacology 2021;12:644116
The Protective Effects of Shengmai Formula Against Myocardial Injury Induced by Ultrafine Particulate Matter Exposure and Myocardial Ischemia are Mediated by the PI3K/AKT/p38 MAPK/Nrf2 Pathway.
Chen L, Guo Y, Qu S, Li K, Yang T, Yang Y, Zheng Z, Liu H, Wang X, Deng S, Zhang Y, Zhu X, Li Y
Frontiers in pharmacology 2021;12:619311
Frontiers in pharmacology 2021;12:619311
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
Lu J, Liu SY, Zhang J, Yang GM, Gao GB, Yu NN, Li YP, Li YX, Ma ZQ, Wang Y, Lu CH
American journal of cancer research 2021;11(7):3575-3593
American journal of cancer research 2021;11(7):3575-3593
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Luo Q, Xian P, Wang T, Wu S, Sun T, Wang W, Wang B, Yang H, Yang Y, Wang H, Liu W, Long Q
Theranostics 2021;11(12):5986-6005
Theranostics 2021;11(12):5986-6005
Nrf2 Down-Regulation by Camptothecin Favors Inhibiting Invasion, Metastasis and Angiogenesis in Hepatocellular Carcinoma.
Liu Q, Zhao S, Meng F, Wang H, Sun L, Li G, Gao F, Chen F
Frontiers in oncology 2021;11:661157
Frontiers in oncology 2021;11:661157
Daphnetin inhibits spinal glial activation via Nrf2/HO-1/NF-κB signaling pathway and attenuates CFA-induced inflammatory pain.
Yang Y, Sheng Q, Nie Z, Liu L, Zhang W, Chen G, Ye F, Shi L, Lv Z, Xie J, Wang D
International immunopharmacology 2021 Sep;98:107882
International immunopharmacology 2021 Sep;98:107882
Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis.
Chen G, Yang Z, Wen D, Guo J, Xiong Q, Li P, Zhao L, Wang J, Wu C, Dong L
Immunity, inflammation and disease 2021 Sep;9(3):959-970
Immunity, inflammation and disease 2021 Sep;9(3):959-970
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells.
Song Q, Peng S, Sun Z, Heng X, Zhu X
Yonsei medical journal 2021 Sep;62(9):843-849
Yonsei medical journal 2021 Sep;62(9):843-849
TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway.
Yu HF, Zheng LW, Yang ZQ, Wang YS, Wang TT, Yue ZP, Guo B
Experimental & molecular medicine 2021 Sep;53(9):1307-1318
Experimental & molecular medicine 2021 Sep;53(9):1307-1318
Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs.
Senyuk V, Eskandari N, Jiang Y, Garcia-Varela R, Sundstrom R, Leanza L, Peruzzo R, Burkard M, Minshall RD, Gentile S
Redox biology 2021 Sep;45:102030
Redox biology 2021 Sep;45:102030
Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway.
Yang S, Zhang X, Zhang H, Lin X, Chen X, Zhang Y, Lin X, Huang L, Zhuge Q
Molecular medicine reports 2021 Sep;24(3)
Molecular medicine reports 2021 Sep;24(3)
N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells.
Peng W, Zhu Z, Yang Y, Hou J, Lu J, Chen C, Liu F, Pi R
Brain research bulletin 2021 Sep;174:250-259
Brain research bulletin 2021 Sep;174:250-259
CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling.
Yu S, Hu Q, Fan K, Yang C, Gao Y
Journal of cell communication and signaling 2021 Sep;15(3):383-392
Journal of cell communication and signaling 2021 Sep;15(3):383-392
Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism.
Yin D, Jin G, He H, Zhou W, Fan Z, Gong C, Zhao J, Xiong H
Aging 2021 Sep 8;13(17):21268-21282
Aging 2021 Sep 8;13(17):21268-21282
Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway.
Luo M, Zheng LW, Wang YS, Huang JC, Yang ZQ, Yue ZP, Guo B
Food & function 2021 Sep 20;12(18):8800-8811
Food & function 2021 Sep 20;12(18):8800-8811
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Zhang Q, Su G, Yang Q, Wei Z, Wang J, Zheng L, Zhao M
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Hu S, Li S, Liu Y, Sun K, Luo L, Zeng L
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome.
Zhang H, Li L, Hao M, Chen K, Lu Y, Qi J, Chen W, Ren L, Cai X, Chen C, Liu Z, Zhao B, Li Z, Hou P
Journal of ethnopharmacology 2021 Sep 15;277:114254
Journal of ethnopharmacology 2021 Sep 15;277:114254
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2.
Sun M, Guo M, Ma G, Zhang N, Pan F, Fan X, Wang R
Toxicology and applied pharmacology 2021 Sep 1;426:115637
Toxicology and applied pharmacology 2021 Sep 1;426:115637
LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.
Zhang Y, Guo S, Wang S, Li X, Hou D, Li H, Wang L, Xu Y, Ma B, Wang H, Jiang X
Ecotoxicology and environmental safety 2021 Sep 1;220:112376
Ecotoxicology and environmental safety 2021 Sep 1;220:112376
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Wen L, Yang QH, Ma XL, Li T, Xiao S, Sun CF
International immunopharmacology 2021 Oct;99:107993
International immunopharmacology 2021 Oct;99:107993
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
Fan S, Liu X, Wang Y, Ren X, Liu Y, Dong Y, Fan Q, Wei J, Ma J, Yu A, Song R, Sui H, Shen M, Fang F, Xia Q, She G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1.
Zhang J, Cui J, Zhao F, Yang L, Xu X, Shi Y, Wei B
Redox biology 2021 Oct;46:102114
Redox biology 2021 Oct;46:102114
Black raspberry (Rubus occidentalis) attenuates inflammatory markers and vascular endothelial dysfunction in Wistar rats fed a high-fat diet with fructose solution.
Park SY, Jung H, Lin Z, Hwang KT, Kwak HK
Journal of food biochemistry 2021 Oct;45(10):e13917
Journal of food biochemistry 2021 Oct;45(10):e13917
Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke.
Li L, Cheng SQ, Guo W, Cai ZY, Sun YQ, Huang XX, Yang J, Ji J, Chen YY, Dong YF, Cheng H, Sun XL
Journal of cellular and molecular medicine 2021 Oct;25(20):9753-9766
Journal of cellular and molecular medicine 2021 Oct;25(20):9753-9766
A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway.
Tan Q, Fang Y, Peng X, Zhou H, Xu J, Gu Q
Bioorganic chemistry 2021 Oct;115:105177
Bioorganic chemistry 2021 Oct;115:105177
The Potential Protective Effect and Possible Mechanism of Peptides from Oyster (Crassostrea hongkongensis) Hydrolysate on Triptolide-Induced Testis Injury in Male Mice.
Zhang X, Peng Z, Zheng H, Zhang C, Lin H, Qin X
Marine drugs 2021 Oct 9;19(10)
Marine drugs 2021 Oct 9;19(10)
Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells.
Kwok HH, Gao B, Chan KH, Ip MS, Minna JD, Lam DC
Cancers 2021 Oct 25;13(21)
Cancers 2021 Oct 25;13(21)
RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma.
Tsai TH, Lieu AS, Huang TY, Kwan AL, Lin CL, Hsu YC
Journal of clinical medicine 2021 Oct 20;10(21)
Journal of clinical medicine 2021 Oct 20;10(21)
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Tian X, Xue Y, Xie G, Zhou Y, Xiao H, Ding F, Zhang M
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Ma Y, Li S, Ye S, Tang S, Hu D, Wei L, Xiao F
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress.
Elkamhawy A, Woo J, Gouda NA, Kim J, Nada H, Roh EJ, Park KD, Cho J, Lee K
Antioxidants (Basel, Switzerland) 2021 Oct 12;10(10)
Antioxidants (Basel, Switzerland) 2021 Oct 12;10(10)
Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury.
Kong L, Deng J, Zhou X, Cai B, Zhang B, Chen X, Chen Z, Wang W
Cell death & disease 2021 Oct 11;12(10):928
Cell death & disease 2021 Oct 11;12(10):928
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Zou Y, Chen Z, Sun C, Yang D, Zhou Z, Peng X, Zheng L, Tang C
International journal of molecular sciences 2021 Oct 10;22(20)
International journal of molecular sciences 2021 Oct 10;22(20)
Protective effects of Nrf2 against sepsis-induced hepatic injury.
Li L, Zhang Q, Zhang X, Xu X, Wang X, Huang X, Wang T, Jiang Z, Xiao L, Zhang L, Sun L
Life sciences 2021 Oct 1;282:119807
Life sciences 2021 Oct 1;282:119807
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Nicotinamide improves NAD(+) levels to protect against acetaminophen-induced acute liver injury in mice.
Xu J, Zhang L, Jiang R, Hu K, Hu D, Liao C, Jiang S, Yang Y, Huang J, Tang L, Li L
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Loss of PHLDA1 has a protective role in OGD/R-injured neurons via regulation of the GSK-3β/Nrf2 pathway.
Yang F, Chen R
Human & experimental toxicology 2021 Nov;40(11):1909-1920
Human & experimental toxicology 2021 Nov;40(11):1909-1920
Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
Cui Q, Yan L
Cell and tissue research 2021 Nov;386(2):349-363
Cell and tissue research 2021 Nov;386(2):349-363
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis.
Meng X, Zhang L, Han B, Zhang Z
Environmental toxicology 2021 Nov;36(11):2266-2277
Environmental toxicology 2021 Nov;36(11):2266-2277
The role of Nrf2 pathway in alleviating fluorine-induced apoptosis by different selenium sources in the chicken duodenum and jejunum.
Ju H, Chen S, Xue Y, Zhang X, Wang Y
Ecotoxicology and environmental safety 2021 Nov;224:112708
Ecotoxicology and environmental safety 2021 Nov;224:112708
Chemical Constituents from the Rhizome of Ligusticum chuanxiong Hort. and Their Nrf2 Inducing Activity.
Zhang K, Fang KL, Wang T, Xu LT, Zhao Y, Wang XN, Xiang L, Shen T
Chemistry & biodiversity 2021 Nov;18(11):e2100302
Chemistry & biodiversity 2021 Nov;18(11):e2100302
Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress.
Yang C, Luo P, Chen SJ, Deng ZC, Fu XL, Xu DN, Tian YB, Huang YM, Liu WJ
Poultry science 2021 Nov;100(11):101459
Poultry science 2021 Nov;100(11):101459
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Wang L, Wang X, Kong L, Wang S, Huang K, Wu J, Wang C, Sun H, Liu K, Meng Q
International immunopharmacology 2021 Nov;100:108159
International immunopharmacology 2021 Nov;100:108159
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Liu Y, Zhou J, Luo Y, Li J, Shang L, Zhou F, Yang S
Chinese medicine 2021 Nov 29;16(1):127
Chinese medicine 2021 Nov 29;16(1):127
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Liu XL, Zhao YC, Zhu HY, Wu M, Zheng YN, Yang M, Cheng ZQ, Ding CB, Liu WC
Food & function 2021 Nov 29;12(23):12142-12158
Food & function 2021 Nov 29;12(23):12142-12158
TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via activation of Nrf2.
Deng S, Wu D, Li L, Li J, Xu Y
Cellular & molecular biology letters 2021 Nov 18;26(1):48
Cellular & molecular biology letters 2021 Nov 18;26(1):48
Cynaropicrin Induces Cell Cycle Arrest and Apoptosis by Inhibiting PKM2 to Cause DNA Damage and Mitochondrial Fission in A549 Cells.
Ding Z, Xi J, Zhong M, Chen F, Zhao H, Zhang B, Fang J
Journal of agricultural and food chemistry 2021 Nov 17;69(45):13557-13567
Journal of agricultural and food chemistry 2021 Nov 17;69(45):13557-13567
Ripened Pu-Erh Tea Improved the Enterohepatic Circulation in a Circadian Rhythm Disorder Mice Model.
Hu S, Chen Y, Zhao S, Sun K, Luo L, Zeng L
Journal of agricultural and food chemistry 2021 Nov 17;69(45):13533-13545
Journal of agricultural and food chemistry 2021 Nov 17;69(45):13533-13545
Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization.
Feng J, Liu Z, Chen H, Zhang M, Ma X, Han Q, Lu D, Wang C
European journal of pharmacology 2021 Nov 15;911:174522
European journal of pharmacology 2021 Nov 15;911:174522
Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway.
Chen Y, Wang J, Li J, Zhu J, Wang R, Xi Q, Wu H, Shi T, Chen W
European journal of pharmacology 2021 Nov 15;911:174518
European journal of pharmacology 2021 Nov 15;911:174518
Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway.
Zhang H, Zhou L, Zhou Y, Wang L, Jiang W, Liu L, Yue S, Zheng P, Liu H
Life sciences 2021 Nov 15;285:119963
Life sciences 2021 Nov 15;285:119963
Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer.
Yang J, Mo J, Dai J, Ye C, Cen W, Zheng X, Jiang L, Ye L
Cell death & disease 2021 Nov 13;12(11):1079
Cell death & disease 2021 Nov 13;12(11):1079
Erythritol Improves Nonalcoholic Fatty Liver Disease by Activating Nrf2 Antioxidant Capacity.
Jin M, Wei Y, Yu H, Ma X, Yan S, Zhao L, Ding L, Cheng J, Feng H
Journal of agricultural and food chemistry 2021 Nov 10;69(44):13080-13092
Journal of agricultural and food chemistry 2021 Nov 10;69(44):13080-13092
Effective-component compatibility of Bufei Yishen formula protects COPD rats against PM2.5-induced oxidative stress via miR-155/FOXO3a pathway.
Li J, Wang J, Li Y, Zhao P, Tian Y, Liu X, He H, Jia R
Ecotoxicology and environmental safety 2021 Nov 10;228:112918
Ecotoxicology and environmental safety 2021 Nov 10;228:112918
Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury.
Xu JJ, Cui J, Lin Q, Chen XY, Zhang J, Gao EH, Wei B, Zhao W
International journal of cardiology 2021 Nov 1;342:82-93
International journal of cardiology 2021 Nov 1;342:82-93
Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage.
Wu B, Wu Y, Fan C, Feng C, Wang H, Bai F, Zuo J, Tang W
International immunopharmacology 2021 May;94:107482
International immunopharmacology 2021 May;94:107482
Trojan Horse Delivery of 4,4'-Dimethoxychalcone for Parkinsonian Neuroprotection.
Zhang W, Chen H, Ding L, Gong J, Zhang M, Guo W, Xu P, Li S, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(9):2004555
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(9):2004555
Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation.
Sun J, Zhou C, Zhao Y, Zhang X, Chen W, Zhou Q, Hu B, Gao D, Raatz L, Wang Z, Nelson PJ, Jiang Y, Ren N, Bruns CJ, Zhou H
Redox biology 2021 May;41:101942
Redox biology 2021 May;41:101942
Expression of COX-2 and Nrf2/GPx3 in the anterior vaginal wall tissues of women with pelvic organ prolapse.
Lin T, Ji Y, Zhao Y, Xia Z
Archives of gynecology and obstetrics 2021 May;303(5):1245-1253
Archives of gynecology and obstetrics 2021 May;303(5):1245-1253
Protective effects of gastrodin pretreatment on mouse hepatic ischemia-reperfusion occurring through antioxidant and anti-apoptotic mechanisms.
Sun B, Jiang J, Zhu X, Yang D, Cui Z, Zhang Y, Zhang M, Qian Y, Liu R, Yang W
Experimental and therapeutic medicine 2021 May;21(5):471
Experimental and therapeutic medicine 2021 May;21(5):471
Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.
Zhou W, Xu C, Dong G, Qiao H, Yang J, Liu H, Ding L, Sun K, Zhao W
European journal of medicinal chemistry 2021 May 5;217:113326
European journal of medicinal chemistry 2021 May 5;217:113326
Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities.
Hori Y, Tsutsumi R, Nasu K, Boateng A, Ashikari Y, Sugiura M, Nakajima M, Kurauchi Y, Hisatsune A, Katsuki H, Seki T
Cells 2021 May 3;10(5)
Cells 2021 May 3;10(5)
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca(2+)/CaMKII/Nrf2 signaling pathway.
Lv Z, Xu X, Sun Z, Yang YX, Guo H, Li J, Sun K, Wu R, Xu J, Jiang Q, Ikegawa S, Shi D
Cell death & disease 2021 May 18;12(6):504
Cell death & disease 2021 May 18;12(6):504
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Upregulation of Chemoresistance by Mg(2+) Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells.
Onuma S, Manabe A, Yoshino Y, Matsunaga T, Asai T, Ikari A
Cells 2021 May 12;10(5)
Cells 2021 May 12;10(5)
4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.
Weng WT, Kuo PC, Brown DA, Scofield BA, Furnas D, Paraiso HC, Wang PY, Yu IC, Yen JH
Journal of neuroinflammation 2021 May 11;18(1):110
Journal of neuroinflammation 2021 May 11;18(1):110
Anti-inflammatory activity of the water extract of Chloranthus serratus roots in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways.
Sun S, Zhang J, Li H, Du Y, Li S, Li A, Suo X, Wang Y, Sun Q
Journal of ethnopharmacology 2021 May 10;271:113880
Journal of ethnopharmacology 2021 May 10;271:113880
Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia.
Yang GX, Sun JM, Zheng LL, Zhang L, Li J, Gan HX, Huang Y, Huang J, Diao XX, Tang Y, Wang R, Ma L
Bioorganic & medicinal chemistry 2021 May 1;37:116109
Bioorganic & medicinal chemistry 2021 May 1;37:116109
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit.
Feng XH, Xu HY, Wang JY, Duan S, Wang YC, Ma CM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153479
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153479
The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2.
Meng C, Zhan J, Chen D, Shao G, Zhang H, Gu W, Luo J
Oncogene 2021 Mar;40(9):1706-1720
Oncogene 2021 Mar;40(9):1706-1720
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Zhang Y, Sun J, Dong Y, Shen X, Zhang Z
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Chondrocyte ferroptosis contribute to the progression of osteoarthritis.
Yao X, Sun K, Yu S, Luo J, Guo J, Lin J, Wang G, Guo Z, Ye Y, Guo F
Journal of orthopaedic translation 2021 Mar;27:33-43
Journal of orthopaedic translation 2021 Mar;27:33-43
Gambogic acid ameliorates high glucose- and palmitic acid-induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo.
Chen J, Li L, Zhou Y, Zhang J, Chen L
Cell stress & chaperones 2021 Mar;26(2):367-375
Cell stress & chaperones 2021 Mar;26(2):367-375
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
Shi M, Huang XY, Ren XY, Wei XY, Ma Y, Lin ZZ, Liu DT, Song L, Zhao TJ, Li G, Yao L, Zhu M, Zhang C, Xie C, Wu Y, Wu HM, Fan LP, Ou J, Zhan YH, Lin SY, Lin SC
Nature cell biology 2021 Mar;23(3):268-277
Nature cell biology 2021 Mar;23(3):268-277
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Free radical biology & medicine 2021 Mar;165:229-242
Free radical biology & medicine 2021 Mar;165:229-242
Oxidative stress in retrotrapezoid nucleus/parafacial respiratory group and impairment of central chemoreception in rat offspring exposed to maternal cigarette smoke.
Lei F, Wang W, Fu Y, Wang J, Zheng Y
Reproductive toxicology (Elmsford, N.Y.) 2021 Mar;100:35-41
Reproductive toxicology (Elmsford, N.Y.) 2021 Mar;100:35-41
Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARγ pathway against oxidative injury in mice hippocampus.
Xiong L, Huang J, Gao Y, Gao Y, Wu C, He S, Zou L, Yang D, Han Y, Yuan Q, Zheng Z, Hu G
Toxicology research 2021 Mar;10(2):277-283
Toxicology research 2021 Mar;10(2):277-283
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Sun Y, He L, Wang W, Wang T, Hua W, Li T, Wang L, Gao T, Chen F, Tang L
Journal of ethnopharmacology 2021 Mar 25;268:113617
Journal of ethnopharmacology 2021 Mar 25;268:113617
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Wang W, Zhai D, Bai Y, Xue K, Deng L, Ma L, Du T, Ye Z, Qu D, Xiang A, Chen G, Zhao Y, Wang L, Lu Z
Cell death discovery 2021 Mar 23;7(1):58
Cell death discovery 2021 Mar 23;7(1):58
Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal Muscle Fiber Atrophy during Simulated Microgravity.
Lawler JM, Hord JM, Ryan P, Holly D, Janini Gomes M, Rodriguez D, Guzzoni V, Garcia-Villatoro E, Green C, Lee Y, Little S, Garcia M, Hill L, Brooks MC, Lawler MS, Keys N, Mohajeri A, Kamal KY
International journal of molecular sciences 2021 Mar 23;22(6)
International journal of molecular sciences 2021 Mar 23;22(6)
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Xie C, Ma H, Shi Y, Li J, Wu H, Wang B, Shao Z, Huang C, Chen J, Sun L, Zhou Y, Tian N, Wu Y, Gao W, Wu A, Wang X, Zhang X
Food & function 2021 Mar 21;12(6):2703-2714
Food & function 2021 Mar 21;12(6):2703-2714
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Mar 17;70(1):67-78
Physiological research 2021 Mar 17;70(1):67-78
Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-κB and Nrf2 pathways.
Guo C, Bi J, Li X, Lyu J, Liu X, Wu X, Liu J
Food chemistry 2021 Mar 15;340:127931
Food chemistry 2021 Mar 15;340:127931
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.
Feng J, Xie L, Yu X, Liu C, Dong H, Lu W, Kong R
Biochemical and biophysical research communications 2021 Mar 12;544:22-30
Biochemical and biophysical research communications 2021 Mar 12;544:22-30
Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway.
Huang S, Mo C, Zeng T, Lai Y, Zhou C, Xie S, Chen L, Wang Y, Chen Y, Huang S, Gao L, Lv Z
Aging 2021 Mar 11;13(5):6592-6605
Aging 2021 Mar 11;13(5):6592-6605
Troxerutin Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.
Wang X, Gao Y, Wang L, Yang D, Bu W, Gou L, Huang J, Duan X, Pan Y, Cao S, Gao Z, Cheng C, Feng Z, Xie J, Yao R
Journal of agricultural and food chemistry 2021 Mar 10;69(9):2729-2744
Journal of agricultural and food chemistry 2021 Mar 10;69(9):2729-2744
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Lu D, Le Y, Ding J, Dou X, Mao W, Zhu J
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.
Peng J, Jiang Z, Wu G, Cai Z, Du Q, Tao L, Zhang Y, Chen Y, Shen X
Journal of drug targeting 2021 Jun;29(5):520-530
Journal of drug targeting 2021 Jun;29(5):520-530
Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.
Dai JM, Guo WN, Tan YZ, Niu KW, Zhang JJ, Liu CL, Yang XM, Tao KS, Chen ZN, Dai JY
Journal of cellular and molecular medicine 2021 Jun;25(12):5782-5798
Journal of cellular and molecular medicine 2021 Jun;25(12):5782-5798
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Li X, Wang X, Miao L, Liu Y, Lin X, Guo Y, Yuan R, Tian H
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Upregulation of antioxidant and autophagy pathways via NRF2 activation protects spinal cord neurons from ozone damage.
Zhang C, Ma S, Zhao X, Wen B, Sun P, Fu Z
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury.
Liu M, Zheng B, Liu P, Zhang J, Chu X, Dong C, Shi J, Liang Y, Chu L, Liu Y, Han X
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Ginkgo biloba delays light-induced photoreceptor degeneration through antioxidant and antiapoptotic properties.
Chudhary M, Zhang C, Song S, Ren X, Kong L
Experimental and therapeutic medicine 2021 Jun;21(6):576
Experimental and therapeutic medicine 2021 Jun;21(6):576
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Zhang Z, Qin X, Wang Z, Li Y, Chen F, Chen R, Li C, Zhang W, Zhang M
Experimental and therapeutic medicine 2021 Jun;21(6):556
Experimental and therapeutic medicine 2021 Jun;21(6):556
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Li X, Wang X, Miao L, Guo Y, Yuan R, Tian H
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Pan H, Xu Y, Cai Q, Wu M, Ding M
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Liu Z, He Q, Liu Y, Zhang Y, Cui M, Peng H, Wang Y, Chen S, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2021 Jun 30;458:152838
Toxicology 2021 Jun 30;458:152838
Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease.
Kawasaki T, Sugihara F, Fukushima K, Matsuki T, Nabeshima H, Machida T, Mitsui Y, Fujimura S, Sagawa R, Gaheun L, Kuniyoshi K, Tanaka H, Narazaki M, Kumanogoh A, Akira S, Satoh T
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 29;118(26)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 29;118(26)
Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis.
Zhang M, Zhang T, Song C, Qu J, Gu Y, Liu S, Li H, Xiao W, Kong L, Sun Y, Lv W
Journal of ethnopharmacology 2021 Jun 28;274:114064
Journal of ethnopharmacology 2021 Jun 28;274:114064
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
Dai C, Li H, Wang Y, Tang S, Velkov T, Shen J
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
Effect of Chronic Stress Present in Fibroblasts Derived from Patients with a Sporadic Form of AD on Mitochondrial Function and Mitochondrial Turnover.
Drabik K, Malińska D, Piecyk K, Dębska-Vielhaber G, Vielhaber S, Duszyński J, Szczepanowska J
Antioxidants (Basel, Switzerland) 2021 Jun 10;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 10;10(6)
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
Zhu Z, Hu R, Li J, Xing X, Chen J, Zhou Q, Sun J
International immunopharmacology 2021 Jul;96:107660
International immunopharmacology 2021 Jul;96:107660
The piperine derivative HJ105 inhibits Aβ(1-42)-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.
Yang X, Zhi J, Leng H, Chen Y, Gao H, Ma J, Ji J, Hu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153571
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153571
Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling.
Luo LF, Guan P, Qin LY, Wang JX, Wang N, Ji ES
Molecular and cellular biochemistry 2021 Jul;476(7):2603-2611
Molecular and cellular biochemistry 2021 Jul;476(7):2603-2611
Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum.
Xue H, Cao H, Xing C, Feng J, Zhang L, Zhang C, Hu G, Yang F
Toxicology 2021 Jul;459:152855
Toxicology 2021 Jul;459:152855
Exosomes are involved in total body irradiation-induced intestinal injury in mice.
Li H, Jiang M, Zhao SY, Zhang SQ, Lu L, He X, Feng GX, Wu X, Fan SJ
Acta pharmacologica Sinica 2021 Jul;42(7):1111-1123
Acta pharmacologica Sinica 2021 Jul;42(7):1111-1123
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Liu X, Li M, Zhu J, Huang W, Song J
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Increased lipid peroxidation by graphene quantum dots induces ferroptosis in macrophages.
Shao Y, Wang L, Chen J, Hunag Y, Huang Y, Wang X, Zhou D, Zhang J, Wu W, Zhang Q, Li F, Xia X, Huang Y
NanoImpact 2021 Jul;23:100334
NanoImpact 2021 Jul;23:100334
Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice.
Cong L, Lei MY, Liu ZQ, Liu ZF, Ma Z, Liu K, Li J, Deng Y, Liu W, Xu B
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Jul;153:112283
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Jul;153:112283
Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis.
Liu P, Li J, Liu M, Zhang M, Xue Y, Zhang Y, Han X, Jing X, Chu L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111552
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111552
Choline attenuates heat stress-induced oxidative injury and apoptosis in bovine mammary epithelial cells by modulating PERK/Nrf-2 signaling pathway.
Yang M, Kuang M, Wang G, Ali I, Tang Y, Yang C, Li Y, Li L
Molecular immunology 2021 Jul;135:388-397
Molecular immunology 2021 Jul;135:388-397
Baicalin-loaded macrophage-derived exosomes ameliorate ischemic brain injury via the antioxidative pathway.
Huang Z, Guo L, Huang L, Shi Y, Liang J, Zhao L
Materials science & engineering. C, Materials for biological applications 2021 Jul;126:112123
Materials science & engineering. C, Materials for biological applications 2021 Jul;126:112123
Tolerable upper intake level of iron damages the liver of weaned piglets.
Ding H, Zhao Y, Yu X, Chen L, Han J, Feng J
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer's disease.
Qu L, Ji L, Wang C, Luo H, Li S, Peng W, Yin F, Lu D, Liu X, Kong L, Wang X
European journal of medicinal chemistry 2021 Jul 5;219:113441
European journal of medicinal chemistry 2021 Jul 5;219:113441
Chlamydia trachomatis Pgp3 protein regulates oxidative stress via activation of the Nrf2/NQO1 signal pathway.
Shu M, Lei W, Su S, Wen Y, Luo F, Zhao L, Chen L, Lu C, Zhou Z, Li Z
Life sciences 2021 Jul 15;277:119502
Life sciences 2021 Jul 15;277:119502
Proteomics analysis in the kidney of mice following oral feeding Realgar.
Zhang S, Li C, Feng T, Cao S, Zhou H, Li L, Hu Q, Mao X, Ji S
Journal of ethnopharmacology 2021 Jul 15;275:114118
Journal of ethnopharmacology 2021 Jul 15;275:114118
The role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence.
Li S, Ma Y, Liang Y, Liang N, Ye S, Xiao F
Ecotoxicology and environmental safety 2021 Jul 15;218:112300
Ecotoxicology and environmental safety 2021 Jul 15;218:112300
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Zhou J, Zhao Y, Guo YJ, Zhao YS, Liu H, Ren J, Li JR, Ji ES
Life sciences 2021 Jul 1;276:119403
Life sciences 2021 Jul 1;276:119403
Salvinorin A protects against methicillin resistant staphylococcus aureus-induced acute lung injury via Nrf2 pathway.
Zeng S, Chen D, Liu G, Wu YX, Gao ZQ, Su Y, Yuan JN, Liu L, Shan JC, Pang QF, Zhu T
International immunopharmacology 2021 Jan;90:107221
International immunopharmacology 2021 Jan;90:107221
Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis.
Wu YX, Zeng S, Wan BB, Wang YY, Sun HX, Liu G, Gao ZQ, Chen D, Chen YQ, Lu MD, Pang QF
International immunopharmacology 2021 Jan;90:107187
International immunopharmacology 2021 Jan;90:107187
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Sun K, Luo J, Jing X, Xiang W, Guo J, Yao X, Liang S, Guo F, Xu T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
RNA-seq reveals novel cancer-selective and disease subtype-independent mechanistic targets of withaferin A in human breast cancer cells.
Hahm ER, Kim SH, Singh KB, Singh SV
Molecular carcinogenesis 2021 Jan;60(1):3-14
Molecular carcinogenesis 2021 Jan;60(1):3-14
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Yang Y, Li J, Zhang L, Lin Z, Xiao H, Sun X, Zhang M, Liu P, Huang H
Pharmacological research 2021 Jan;163:105333
Pharmacological research 2021 Jan;163:105333
Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I.
Zeng H, Wang L, Zhang J, Pan T, Yu Y, Lu J, Zhou P, Yang H, Li P
Acta pharmaceutica Sinica. B 2021 Jan;11(1):71-88
Acta pharmaceutica Sinica. B 2021 Jan;11(1):71-88
Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT.
Bai Y, Wang W, Wang L, Ma L, Zhai D, Wang F, Shi R, Liu C, Xu Q, Chen G, Lu Z
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Lv H, Sun X, Jia H, Xu C
Food & function 2021 Jan 21;12(2):696-705
Food & function 2021 Jan 21;12(2):696-705
Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.
Li S, Wang X, Xiao Y, Wang Y, Wan Y, Li X, Li Q, Tang X, Cai D, Ran B, Wu C
Ecotoxicology and environmental safety 2021 Jan 15;208:111426
Ecotoxicology and environmental safety 2021 Jan 15;208:111426
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Jan 14;70(1)
Physiological research 2021 Jan 14;70(1)
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
Liang J, Zhou X, Wang J, Fei ZY, Qin GC, Zhang DK, Zhou JY, Chen LX
Neuroreport 2021 Jan 13;32(2):144-156
Neuroreport 2021 Jan 13;32(2):144-156
The Time-Course of Antioxidant Irisin Activity: Role of the Nrf2/HO-1/HMGB1 Axis.
Mazur-Bialy AI, Pocheć E
Antioxidants (Basel, Switzerland) 2021 Jan 11;10(1)
Antioxidants (Basel, Switzerland) 2021 Jan 11;10(1)
Klotho ameliorates diabetic nephropathy by activating Nrf2 signaling pathway in podocytes.
Xing L, Guo H, Meng S, Zhu B, Fang J, Huang J, Chen J, Wang Y, Wang L, Yao X, Wang H
Biochemical and biophysical research communications 2021 Jan 1;534:450-456
Biochemical and biophysical research communications 2021 Jan 1;534:450-456
Dietary alpha-lipoic acid supplementation improves spermatogenesis and semen quality via antioxidant and anti-apoptotic effects in aged breeder roosters.
Ye N, Lv Z, Dai H, Huang Z, Shi F
Theriogenology 2021 Jan 1;159:20-27
Theriogenology 2021 Jan 1;159:20-27
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
Guo C, Zhang Y, Nie Q, Cao D, Wang X, Wan X, Liu M, Cui J, Sun J, Bai Y, Li L
Neurobiology of aging 2021 Feb;98:10-20
Neurobiology of aging 2021 Feb;98:10-20
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration.
Sivalingam K, Cirino TJ, McLaughlin JP, Samikkannu T
Molecular neurobiology 2021 Feb;58(2):490-504
Molecular neurobiology 2021 Feb;58(2):490-504
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Cui W, Wu X, Shi Y, Guo W, Luo J, Liu H, Zheng L, Du Y, Wang P, Wang Q, Feng D, Ge S, Qu Y
Cell proliferation 2021 Feb;54(2):e12964
Cell proliferation 2021 Feb;54(2):e12964
Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress.
Li Z, Wang Y, Zhang Y, Wang X, Gao B, Li Y, Li R, Wang J
Archives of medical research 2021 Feb;52(2):163-173
Archives of medical research 2021 Feb;52(2):163-173
H(2)S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434.
Li N, Wang J, Zang X, Wang Z, Zhang T, Zhao B, Miao J, Lin Z
Apoptosis : an international journal on programmed cell death 2021 Feb;26(1-2):111-131
Apoptosis : an international journal on programmed cell death 2021 Feb;26(1-2):111-131
Exercise reduces hyperlipidemia-induced kidney damage in apolipoprotein E-deficient mice.
Qian C, Yang Q, Guo L, Zhu H, You X, Liu H, Sun Y
Experimental and therapeutic medicine 2021 Feb;21(2):153
Experimental and therapeutic medicine 2021 Feb;21(2):153
Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage.
Bakalarz D, Surmiak M, Yang X, Wójcik D, Korbut E, Śliwowski Z, Ginter G, Buszewicz G, Brzozowski T, Cieszkowski J, Głowacka U, Magierowska K, Pan Z, Wang B, Magierowski M
Acta pharmaceutica Sinica. B 2021 Feb;11(2):456-475
Acta pharmaceutica Sinica. B 2021 Feb;11(2):456-475
Marine algal polysaccharides alleviate aflatoxin B1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers.
Guo Y, Balasubramanian B, Zhao ZH, Liu WC
Poultry science 2021 Feb;100(2):844-857
Poultry science 2021 Feb;100(2):844-857
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Zhang C, Nie P, Zhou C, Hu Y, Duan S, Gu M, Jiang D, Wang Y, Deng Z, Chen J, Chen S, Wang L
Cell death & disease 2021 Feb 24;12(2):209
Cell death & disease 2021 Feb 24;12(2):209
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Wang Z, Cai B, Cao C, Lv H, Dai Y, Zheng M, Zhao G, Peng Y, Gou W, Wang J, Liu D, Hu Y
Free radical biology & medicine 2021 Feb 20;164:249-257
Free radical biology & medicine 2021 Feb 20;164:249-257
Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress.
Zhang MH, Li J, Zhu XY, Zhang YQ, Ye ST, Leng YR, Yang T, Zhang H, Kong LY
Free radical biology & medicine 2021 Feb 20;164:1-12
Free radical biology & medicine 2021 Feb 20;164:1-12
Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice.
Farooqui Z, Mohammad RS, Lokhandwala MF, Banday AA
Clinical and experimental hypertension (New York, N.Y. : 1993) 2021 Feb 17;43(2):175-180
Clinical and experimental hypertension (New York, N.Y. : 1993) 2021 Feb 17;43(2):175-180
Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway.
Cheng J, Xu T, Xun C, Guo H, Cao R, Gao S, Sheng W
Life sciences 2021 Feb 1;266:118905
Life sciences 2021 Feb 1;266:118905
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
Tocmo R, Le B, Heun A, van Pijkeren JP, Parkin K, Johnson JJ
Free radical biology & medicine 2021 Feb 1;163:102-115
Free radical biology & medicine 2021 Feb 1;163:102-115
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Yang RZ, Zheng HL, Xu WN, Zheng XF, Li B, Jiang LS, Jiang SD
Aging 2021 Feb 1;13(3):4647-4662
Aging 2021 Feb 1;13(3):4647-4662
ATF3 regulates oxidative stress and extracellular matrix degradation via p38/Nrf2 signaling pathway in pelvic organ prolapse.
Feng J, Li Y, Jin X, Gong R, Xia Z
Tissue & cell 2021 Dec;73:101660
Tissue & cell 2021 Dec;73:101660
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Feng Z, Wang C, Yue, Jin, Meng Q, Wu J, Sun H
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Pharmaceutical biology 2021 Dec;59(1):1106-1116
CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway.
Xu Y, Sang W, Zhong Y, Xue S, Yang M, Wang C, Lu H, Huan R, Mao X, Zhu L, He C, Ma J
Cell proliferation 2021 Dec;54(12):e13142
Cell proliferation 2021 Dec;54(12):e13142
Dimethyl fumarate ameliorates endotoxin-induced acute kidney injury against macrophage oxidative stress.
Zhou K, Xie M, Yi S, Tang Y, Luo H, Xiao Q, Xiao J, Li Y
Renal failure 2021 Dec;43(1):1229-1239
Renal failure 2021 Dec;43(1):1229-1239
Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway.
Wu YX, Wang YY, Gao ZQ, Chen D, Liu G, Wan BB, Jiang FJ, Wei MX, Zuo J, Zhu J, Chen YQ, Qian F, Pang QF
Acta pharmacologica Sinica 2021 Dec;42(12):2069-2081
Acta pharmacologica Sinica 2021 Dec;42(12):2069-2081
Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the Akt-GSK3β and Nrf2-Keap1-HO-1 pathways in vitro and in vivo murine models of Alzheimer's disease.
Bian Y, Chen Y, Wang X, Cui G, Ung COL, Lu JH, Cong W, Tang B, Lee SM
Journal of advanced research 2021 Dec;34:1-12
Journal of advanced research 2021 Dec;34:1-12
Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer.
Gao Q, Wu Y, Lu C, Kai W, Xie W, Wang Q, Wang L, Liu S, Pan Y
Cell cycle (Georgetown, Tex.) 2021 Dec;20(23):2465-2475
Cell cycle (Georgetown, Tex.) 2021 Dec;20(23):2465-2475
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Song Z, Gao C, Jiang Q, Xu J, Xiong L, Liu K, Sun D, Li H, Chen L
Phytochemistry 2021 Dec;192:112971
Phytochemistry 2021 Dec;192:112971
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Tong J, Fang J, Zhu T, Xiang P, Shang J, Chen L, Zhao J, Wang Y, Tong L, Sun M
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.
Shen PC, Chou SH, Lu CC, Huang HT, Chien SH, Huang PJ, Liu ZM, Shih CL, Su SJ, Chen LM, Tien YC
Cartilage 2021 Dec;13(2_suppl):238S-253S
Cartilage 2021 Dec;13(2_suppl):238S-253S
MicroRNA miR-106a-5p targets forkhead box transcription factor FOXC1 to suppress the cell proliferation, migration, and invasion of ectopic endometrial stromal cells via the PI3K/Akt/mTOR signaling pathway.
Zhou X, Chen Z, Pei L, Sun J
Bioengineered 2021 Dec;12(1):2203-2213
Bioengineered 2021 Dec;12(1):2203-2213
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.
Zhang L, Zhu T, He F, Li X
International immunopharmacology 2021 Dec;101(Pt B):108238
International immunopharmacology 2021 Dec;101(Pt B):108238
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
Zhu F, Shao J, Tian Y, Xu Z
International immunopharmacology 2021 Dec;101(Pt B):108221
International immunopharmacology 2021 Dec;101(Pt B):108221
Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens.
Dai H, Lv Z, Huang Z, Ye N, Li S, Jiang J, Cheng Y, Shi F
Poultry science 2021 Dec;100(12):101499
Poultry science 2021 Dec;100(12):101499
Lack of Type I Interferon Signaling Ameliorates Respiratory Syncytial Virus-Induced Lung Inflammation and Restores Antioxidant Defenses.
Ansar M, Qu Y, Ivanciuc T, Garofalo RP, Casola A
Antioxidants (Basel, Switzerland) 2021 Dec 28;11(1)
Antioxidants (Basel, Switzerland) 2021 Dec 28;11(1)
A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD(2)-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus.
Iwasa K, Yamamoto S, Yamashina K, Yagishita-Kyo N, Maruyama K, Awaji T, Takei Y, Hirasawa A, Yoshikawa K
Journal of neuroinflammation 2021 Dec 27;18(1):304
Journal of neuroinflammation 2021 Dec 27;18(1):304
Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.
Huang D, Chowdhury S, Wang H, Savage SR, Ivey RG, Kennedy JJ, Whiteaker JR, Lin C, Hou X, Oberg AL, Larson MC, Eskandari N, Delisi DA, Gentile S, Huntoon CJ, Voytovich UJ, Shire ZJ, Yu Q, Gygi SP, Hoofnagle AN, Herbert ZT, Lorentzen TD, Calinawan A, Karnitz LM, Weroha SJ, Kaufmann SH, Zhang B, Wang P, Birrer MJ, Paulovich AG
Cell reports. Medicine 2021 Dec 21;2(12):100471
Cell reports. Medicine 2021 Dec 21;2(12):100471
Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.
Hong Y, Zhou Y, Shen L, Wei Y, Long C, Fu Y, Wu H, Wang J, Wu Y, Wu S, Wei G
Ecotoxicology and environmental safety 2021 Dec 20;227:112889
Ecotoxicology and environmental safety 2021 Dec 20;227:112889
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.
Feng X, Jiang T, Yang C, Pang S, Ding Z, Hu H, Wang H, Dong L, Yang N
Cell death & disease 2021 Dec 17;13(1):6
Cell death & disease 2021 Dec 17;13(1):6
Fucoxanthin regulates Nrf2 signaling to decrease oxidative stress and improves renal fibrosis depending on Sirt1 in HG-induced GMCs and STZ-induced diabetic rats.
Yang G, Li Q, Peng J, Jin L, Zhu X, Zheng D, Zhang Y, Wang R, Song Y, Hu W, Xie X
European journal of pharmacology 2021 Dec 15;913:174629
European journal of pharmacology 2021 Dec 15;913:174629
Lactoferrin Alleviates Acute Alcoholic Liver Injury by Improving Redox-Stress Response Capacity in Female C57BL/6J Mice.
Li D, Hu Z, He Q, Guo Y, Chong Y, Xu J, Qin L
Journal of agricultural and food chemistry 2021 Dec 15;69(49):14856-14867
Journal of agricultural and food chemistry 2021 Dec 15;69(49):14856-14867
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Wang Y, Jin R, Chen J, Cao J, Xiao J, Li X, Sun C
Food chemistry 2021 Dec 15;365:130470
Food chemistry 2021 Dec 15;365:130470
Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.
Ye S, Li S, Ma Y, Hu D, Xiao F
Ecotoxicology and environmental safety 2021 Dec 1;225:112779
Ecotoxicology and environmental safety 2021 Dec 1;225:112779
Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway.
Cao L, Zhao J, Ma L, Chen J, Xu J, Rahman SU, Feng S, Li Y, Wu J, Wang X
Ecotoxicology and environmental safety 2021 Dec 1;225:112737
Ecotoxicology and environmental safety 2021 Dec 1;225:112737
Glutaredoxin 1 protects neurons from oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3β/Nrf2 signaling.
Qiu Z, Li X, Duan C, Li R, Han L
Journal of bioenergetics and biomembranes 2021 Aug;53(4):369-379
Journal of bioenergetics and biomembranes 2021 Aug;53(4):369-379
The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
Tan Y, Cao H, Li Q, Sun J
Cell biology international 2021 Aug;45(8):1654-1665
Cell biology international 2021 Aug;45(8):1654-1665
PLK2 protects retinal ganglion cells from oxidative stress by potentiating Nrf2 signaling via GSK-3β.
Fan Y, Wang J, He N, Feng H
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22815
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22815
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis.
Liu M, Fan Y, Li D, Han B, Meng Y, Chen F, Liu T, Song Z, Han Y, Huang L, Chang Y, Cao P, Nakai A, Tan K
Molecular oncology 2021 Aug;15(8):2084-2105
Molecular oncology 2021 Aug;15(8):2084-2105
Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death.
Zhang L, Zou L, Jiang X, Cheng S, Zhang J, Qin X, Qin Z, Chen C, Zou Z
Nanotoxicology 2021 Aug;15(6):779-797
Nanotoxicology 2021 Aug;15(6):779-797
The in vitro and in vivo study of oleanolic acid indole derivatives as novel anti-inflammatory agents: Synthesis, biological evaluation, and mechanistic analysis.
Jin J, He H, Zhang X, Wu R, Gan L, Li D, Lu Y, Wu P, Wong WL, Zhang K
Bioorganic chemistry 2021 Aug;113:104981
Bioorganic chemistry 2021 Aug;113:104981
Isoeucommin A attenuates kidney injury in diabetic nephropathy through the Nrf2/HO-1 pathway.
Huang Q, Ouyang DS, Liu Q
FEBS open bio 2021 Aug;11(8):2350-2363
FEBS open bio 2021 Aug;11(8):2350-2363
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
Wei N, Lu T, Yang L, Dong Y, Liu X
FEBS open bio 2021 Aug;11(8):2118-2126
FEBS open bio 2021 Aug;11(8):2118-2126
Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway.
Guo S, Yang J, Qin J, Qazi IH, Pan B, Zang S, Lv T, Deng S, Fang Y, Zhou G
Animals : an open access journal from MDPI 2021 Aug 6;11(8)
Animals : an open access journal from MDPI 2021 Aug 6;11(8)
Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism.
Liu C, Hua H, Zhu H, Cheng Y, Guo Y, Yao W, Qian H
International journal of biological macromolecules 2021 Aug 31;185:804-812
International journal of biological macromolecules 2021 Aug 31;185:804-812
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl(4)-induced liver injury in vivo.
Xin C, Liu S, Qu H, Wang Z
International journal of biological macromolecules 2021 Aug 31;185:338-349
International journal of biological macromolecules 2021 Aug 31;185:338-349
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer.
Xie C, Zhou X, Liang C, Li X, Ge M, Chen Y, Yin J, Zhu J, Zhong C
Journal of experimental & clinical cancer research : CR 2021 Aug 24;40(1):266
Journal of experimental & clinical cancer research : CR 2021 Aug 24;40(1):266
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Hong J, Shi Z, Li C, Ji X, Li S, Chen Y, Jiang G, Shi M, Wang W, Zhang Y, Hu B, Yan S
Free radical biology & medicine 2021 Aug 1;171:365-378
Free radical biology & medicine 2021 Aug 1;171:365-378
PSMD12 promotes glioma progression by upregulating the expression of Nrf2.
Wang Z, Li Z, Xu H, Liao Y, Sun C, Chen Y, Sheng M, Lan Q, Wang Z
Annals of translational medicine 2021 Apr;9(8):700
Annals of translational medicine 2021 Apr;9(8):700
Silicon Oxynitrophosphide Nanoscale Coating Enhances Antioxidant Marker-Induced Angiogenesis During in vivo Cranial Bone-Defect Healing.
do Monte FA, Ahuja N, Awad KR, Pan Z, Young S, Kim HK, Aswath P, Brotto M, Varanasi VG
JBMR plus 2021 Apr;5(4):e10425
JBMR plus 2021 Apr;5(4):e10425
Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.
Liu K, Yang W, Hu M, Xie W, Huang J, Cui M, He X, Nie X
Journal of cellular and molecular medicine 2021 Apr;25(8):3976-3990
Journal of cellular and molecular medicine 2021 Apr;25(8):3976-3990
Myricetin protects against H(2) O(2) -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
Kan X, Liu J, Chen Y, Guo W, Xu D, Cheng J, Cao Y, Yang Z, Fu S
Journal of cellular physiology 2021 Apr;236(4):2684-2695
Journal of cellular physiology 2021 Apr;236(4):2684-2695
Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.
Yuan J, Che S, Ruan Z, Song L, Tang R, Zhang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Apr;150:112098
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Apr;150:112098
Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy.
Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Journal of dairy science 2021 Apr;104(4):4516-4528
Journal of dairy science 2021 Apr;104(4):4516-4528
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Zhu Y, Wang C, Luo J, Hua S, Li D, Peng L, Liu H, Song L
Food & function 2021 Apr 7;12(7):3120-3131
Food & function 2021 Apr 7;12(7):3120-3131
Heme-Mediated Activation of the Nrf2/HO-1 Axis Attenuates Calcification of Valve Interstitial Cells.
Balogh E, Chowdhury A, Ababneh H, Csiki DM, Tóth A, Jeney V
Biomedicines 2021 Apr 15;9(4)
Biomedicines 2021 Apr 15;9(4)
AKR1B10 negatively regulates autophagy through reducing GAPDH upon glucose starvation in colon cancer.
Li W, Liu C, Huang Z, Shi L, Zhong C, Zhou W, Meng P, Li Z, Wang S, Luo F, Yan J, Wu T
Journal of cell science 2021 Apr 15;134(8)
Journal of cell science 2021 Apr 15;134(8)
Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.
Yuan J, Che S, Zhang L, Ruan Z
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4101-4110
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4101-4110
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Wang Y, Wang HL, Xing GD, Qian Y, Zhong JF, Chen KL
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Zhang J, Jiang D, Lin S, Cheng Y, Pan J, Ding W, Chen Y, Fan J
Life sciences 2021 Apr 1;270:119131
Life sciences 2021 Apr 1;270:119131
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κB Pathway.
Wu J, Yang CL, Sha YK, Wu Y, Liu ZY, Yuan ZH, Sun ZL
The American journal of Chinese medicine 2020;48(1):127-142
The American journal of Chinese medicine 2020;48(1):127-142
Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.
Zhu Q, Zeng J, Li J, Chen X, Miao J, Jin Q, Chen H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9817932
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9817932
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Meng X, Zhang C, Guo Y, Han Y, Wang C, Chu H, Kong L, Ma H
Oxidative medicine and cellular longevity 2020;2020:8787156
Oxidative medicine and cellular longevity 2020;2020:8787156
Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by Aβ (25-35) and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.
Yu X, Li Y, Mu X
BioMed research international 2020;2020:8210578
BioMed research international 2020;2020:8210578
Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2.
Xu C, Hou B, He P, Ma P, Yang X, Yang X, Zhang L, Qiang G, Li W, Du G
Oxidative medicine and cellular longevity 2020;2020:6431459
Oxidative medicine and cellular longevity 2020;2020:6431459
Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells.
Feng LX, Zhao F, Liu Q, Peng JC, Duan XJ, Yan P, Wu X, Wang HS, Deng YH, Duan SB
Oxidative medicine and cellular longevity 2020;2020:6123459
Oxidative medicine and cellular longevity 2020;2020:6123459
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Tian TT, Li QR, Gan SQ, Chang CR, Shen XC
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
The Nrf2/PGC1α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer.
Deng X, Lin N, Fu J, Xu L, Luo H, Jin Y, Liu Y, Sun L, Su J
Oxidative medicine and cellular longevity 2020;2020:4830418
Oxidative medicine and cellular longevity 2020;2020:4830418
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Qi J, Chen X, Wu Q, Wang J, Zhang H, Mao A, Zhu M, Miao C
Oxidative medicine and cellular longevity 2020;2020:3985089
Oxidative medicine and cellular longevity 2020;2020:3985089
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Du J, He W, Zhang C, Wu J, Li Z, Wang M, Feng S, Liang G
BioMed research international 2020;2020:3243906
BioMed research international 2020;2020:3243906
Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation.
Jin M, Feng H, Wang Y, Yan S, Shen B, Li Z, Qin H, Wang Q, Li J, Liu G
Oxidative medicine and cellular longevity 2020;2020:2940746
Oxidative medicine and cellular longevity 2020;2020:2940746
Comparative effectiveness of 4 natural and chemical activators of Nrf2 on inflammation, oxidative stress, macrophage polarization, and bactericidal activity in an in vitro macrophage infection model.
Ali M, Bonay M, Vanhee V, Vinit S, Deramaudt TB
PloS one 2020;15(6):e0234484
PloS one 2020;15(6):e0234484
Mechanisms and therapeutic implications of RTA 408, an activator of Nrf2, in subarachnoid hemorrhage-induced delayed cerebral vasospasm and secondary brain injury.
Tsai TH, Lin SH, Wu CH, Tsai YC, Yang SF, Lin CL
PloS one 2020;15(10):e0240122
PloS one 2020;15(10):e0240122
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Yuan L, Li Q, Bai D, Shang X, Hu F, Chen Z, An T, Chen Y, Zhang X
International journal of nanomedicine 2020;15:3415-3431
International journal of nanomedicine 2020;15:3415-3431
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo.
Wang H, Jiang Z, Pang Z, Zhou T, Gu Y
Drug design, development and therapy 2020;14:4801-4813
Drug design, development and therapy 2020;14:4801-4813
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Gao Z, Sui J, Fan R, Qu W, Dong X, Sun D
Drug design, development and therapy 2020;14:1971-1982
Drug design, development and therapy 2020;14:1971-1982
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Qi D, Liu H, Sun X, Luo D, Zhu M, Tao T, Gao C, Zhou C, Zhou W, Xiao J
Frontiers in pharmacology 2020;11:621110
Frontiers in pharmacology 2020;11:621110
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Hu J, Zhu Z, Ying H, Yao J, Ma H, Li L, Zhao Y
Frontiers in pharmacology 2020;11:605065
Frontiers in pharmacology 2020;11:605065
Rutaecarpine Ameliorates Ethanol-Induced Gastric Mucosal Injury in Mice by Modulating Genes Related to Inflammation, Oxidative Stress and Apoptosis.
Ren S, Wei Y, Wang R, Wei S, Wen J, Yang T, Chen X, Wu S, Jing M, Li H, Wang M, Zhao Y
Frontiers in pharmacology 2020;11:600295
Frontiers in pharmacology 2020;11:600295
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.
Li C, Zhang S, Li L, Hu Q, Ji S
Frontiers in pharmacology 2020;11:594496
Frontiers in pharmacology 2020;11:594496
Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling.
Lin Y, Luo T, Weng A, Huang X, Yao Y, Fu Z, Li Y, Liu A, Li X, Chen D, Pan H
Frontiers in immunology 2020;11:580593
Frontiers in immunology 2020;11:580593
Formononetin Attenuates Airway Inflammation and Oxidative Stress in Murine Allergic Asthma.
Yi L, Cui J, Wang W, Tang W, Teng F, Zhu X, Qin J, Wuniqiemu T, Sun J, Wei Y, Dong J
Frontiers in pharmacology 2020;11:533841
Frontiers in pharmacology 2020;11:533841
α-Cyperone Attenuates H(2)O(2)-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2.
Huang B, Liu J, Fu S, Zhang Y, Li Y, He D, Ran X, Yan X, Du J, Meng T, Gao X, Liu D
Frontiers in pharmacology 2020;11:281
Frontiers in pharmacology 2020;11:281
Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling.
Liu D, Bai X, Ma W, Xin D, Chu X, Yuan H, Qiu J, Ke H, Yin S, Chen W, Wang Z
Frontiers in pharmacology 2020;11:204
Frontiers in pharmacology 2020;11:204
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Chen S, Ding R, Hu Z, Yin X, Xiao F, Zhang W, Yan S, Lv C
Frontiers in immunology 2020;11:1829
Frontiers in immunology 2020;11:1829
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Wang J, Fang Z, Song C, Kang H, Guo Q, Dong Y, Zhang Y, Peng R, Guan H, Li F
Frontiers in pharmacology 2020;11:1175
Frontiers in pharmacology 2020;11:1175
Kaempferol Protects Blood Vessels From Damage Induced by Oxidative Stress and Inflammation in Association With the Nrf2/HO-1 Signaling Pathway.
Yao H, Sun J, Wei J, Zhang X, Chen B, Lin Y
Frontiers in pharmacology 2020;11:1118
Frontiers in pharmacology 2020;11:1118
Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle.
Wei J, Hao Q, Chen C, Li J, Han X, Lei Z, Wang T, Wang Y, You X, Chen X, Li H, Ding Y, Huang W, Hu Y, Lin S, Shen H, Lin Y
Theranostics 2020;10(20):9230-9248
Theranostics 2020;10(20):9230-9248
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
Li R, Xiao J, Tang S, Lin X, Xu H, Han B, Yang M, Liu F
Molecular medicine reports 2020 Sep;22(3):2545-2550
Molecular medicine reports 2020 Sep;22(3):2545-2550
Sp4 controls constitutive expression of neuronal serine racemase and NF-E2-related factor-2 mediates its induction by valproic acid.
Zhang H, Lu J, Wu S
Biochimica et biophysica acta. Gene regulatory mechanisms 2020 Sep;1863(9):194597
Biochimica et biophysica acta. Gene regulatory mechanisms 2020 Sep;1863(9):194597
Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy.
Chen L, Liao F, Jiang Z, Zhang C, Wang Z, Luo P, Jiang Q, Wu J, Wang Q, Luo M, Li X, Leng Y, Ma L, Shen G, Chen Z, Wang Y, Tan X, Gan Y, Liu D, Liu Y, Shi C
British journal of pharmacology 2020 Sep;177(17):3991-4006
British journal of pharmacology 2020 Sep;177(17):3991-4006
PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway.
Zhou YQ, Liu DQ, Chen SP, Chen N, Sun J, Wang XM, Li DY, Tian YK, Ye DW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110356
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110356
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Kong H, Wang H, Zhuo Z, Li Z, Tian P, Wu J, Liu J, Chen Z, Zhang J, Luo Q
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
Cholestasis Differentially Affects Liver Connexins.
Cooreman A, Van Campenhout R, Crespo Yanguas S, Gijbels E, Leroy K, Pieters A, Tabernilla A, Van Brantegem P, Annaert P, Cogliati B, Vinken M
International journal of molecular sciences 2020 Sep 7;21(18)
International journal of molecular sciences 2020 Sep 7;21(18)
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Jiang TY, Pan YF, Wan ZH, Lin YK, Zhu B, Yuan ZG, Ma YH, Shi YY, Zeng TM, Dong LW, Tan YX, Wang HY
Science translational medicine 2020 Sep 23;12(562)
Science translational medicine 2020 Sep 23;12(562)
Astaxanthin attenuates oxidative stress and immune impairment in D-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway.
Chen Z, Xiao J, Liu H, Yao K, Hou X, Cao Y, Liu X
Food & function 2020 Sep 23;11(9):8099-8111
Food & function 2020 Sep 23;11(9):8099-8111
(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis.
Wang M, Liu CY, Wang T, Yu HM, Ouyang SH, Wu YP, Gong HB, Ma XH, Jiao GL, Fu LL, Wu QS, Kurihara H, Li YF, Shen T, He RR
Cell death & disease 2020 Sep 19;11(9):781
Cell death & disease 2020 Sep 19;11(9):781
NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest.
Sun X, Wang Y, Ji K, Liu Y, Kong Y, Nie S, Li N, Hao J, Xie Y, Xu C, Du L, Liu Q
Nucleic acids research 2020 Sep 18;48(16):9109-9123
Nucleic acids research 2020 Sep 18;48(16):9109-9123
Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study.
Terada K, Murata A, Toki E, Goto S, Yamakawa H, Setoguchi S, Watase D, Koga M, Takata J, Matsunaga K, Karube Y
Molecules (Basel, Switzerland) 2020 Sep 14;25(18)
Molecules (Basel, Switzerland) 2020 Sep 14;25(18)
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Zhang B, Yu D, Luo N, Yang C, Zhu Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
Liraglutide Up-regulation Thioredoxin Attenuated Müller Cells Apoptosis in High Glucose by Regulating Oxidative Stress and Endoplasmic Reticulum Stress.
Ren X, Sun L, Wei L, Liu J, Zhu J, Yu Q, Kong H, Kong L
Current eye research 2020 Oct;45(10):1283-1291
Current eye research 2020 Oct;45(10):1283-1291
Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
Sun Q, Ye Z, Qin Y, Fan G, Ji S, Zhuo Q, Xu W, Liu W, Hu Q, Liu M, Zhang Z, Xu X, Yu X
Oncogene 2020 Oct;39(42):6572-6588
Oncogene 2020 Oct;39(42):6572-6588
NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway.
Liu P, Wu D, Duan J, Xiao H, Zhou Y, Zhao L, Feng Y
Redox biology 2020 Oct;37:101702
Redox biology 2020 Oct;37:101702
MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
Wang T, Jian Z, Baskys A, Yang J, Li J, Guo H, Hei Y, Xian P, He Z, Li Z, Li N, Long Q
Biomaterials 2020 Oct;257:120264
Biomaterials 2020 Oct;257:120264
MiR-23a-5p exacerbates intestinal ischemia-reperfusion injury by promoting oxidative stress via targeting PPAR alpha.
Li LX, Yin LH, Gao M, Xu LN, Qi Y, Peng JY
Biochemical pharmacology 2020 Oct;180:114194
Biochemical pharmacology 2020 Oct;180:114194
Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway.
Gou Z, Su X, Hu X, Zhou Y, Huang L, Fan Y, Li J, Lu L
Brain research bulletin 2020 Oct;163:40-48
Brain research bulletin 2020 Oct;163:40-48
Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage.
Xiong Y, Xin DQ, Hu Q, Wang LX, Qiu J, Yuan HT, Chu XL, Liu DX, Li G, Wang Z
Neural regeneration research 2020 Oct;15(10):1920-1930
Neural regeneration research 2020 Oct;15(10):1920-1930
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Tanshinone IIA attenuates acetaminophen-induced hepatotoxicity through HOTAIR-Nrf2-MRP2/4 signaling pathway.
Zhang X, Wang T, Yang Y, Li R, Chen Y, Li R, Jiang X, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110547
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110547
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D(3) Plus Nicotine.
Liou SF, Nguyen TTN, Hsu JH, Sulistyowati E, Huang SE, Wu BN, Lin MC, Yeh JL
Antioxidants (Basel, Switzerland) 2020 Oct 6;9(10)
Antioxidants (Basel, Switzerland) 2020 Oct 6;9(10)
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.
Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO Jr, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC
Cell metabolism 2020 Oct 6;32(4):561-574.e7
Cell metabolism 2020 Oct 6;32(4):561-574.e7
Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease.
Zhang W, Gong J, Ding L, Zhang Z, Pan X, Chen X, Guo W, Zhang X, Yang X, Peng G, Lin Y, Gao F, Li Y, Zhu X, Xuan A, Wang S, Sun X, Zhang Y, Xu P
Cell death & disease 2020 Oct 22;11(10):897
Cell death & disease 2020 Oct 22;11(10):897
Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway.
Qin X, Hua J, Lin SJ, Zheng HT, Wang JJ, Li W, Ke JJ, Cai HB
Biochemical and biophysical research communications 2020 Oct 20;531(3):431-437
Biochemical and biophysical research communications 2020 Oct 20;531(3):431-437
Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.
Yu Z, Yang L, Deng S, Liang M
European journal of pharmacology 2020 Oct 15;885:173399
European journal of pharmacology 2020 Oct 15;885:173399
Upregulation of Glutaredoxin 2 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and ROS production in neurons by enhancing Nrf2 signaling via modulation of GSK-3β.
Wen J, Li X, Zheng S, Xiao Y
Brain research 2020 Oct 15;1745:146946
Brain research 2020 Oct 15;1745:146946
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.
Wang Y, Lian M, Zhou J, Wu S
Molecular neurobiology 2020 Nov;57(11):4417-4437
Molecular neurobiology 2020 Nov;57(11):4417-4437
Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.
Li M, Liu P, Xue Y, Liang Y, Shi J, Han X, Zhang J, Chu X, Chu L
Oncology reports 2020 Nov;44(5):2306-2316
Oncology reports 2020 Nov;44(5):2306-2316
A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation.
Pan LL, Ren Z, Liu Y, Zhao Y, Li H, Pan X, Fang X, Liang W, Wang Y, Yang J, Sun J
Journal of cellular and molecular medicine 2020 Nov;24(22):12955-12969
Journal of cellular and molecular medicine 2020 Nov;24(22):12955-12969
Crocin ameliorates arsenic trioxide‑induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis.
Liang Y, Zheng B, Li J, Shi J, Chu L, Han X, Chu X, Zhang X, Zhang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110713
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110713
Down-regulation of miR-383-5p suppresses apoptosis in oxidative stress rat hepatocytes by targeting Bcl2.
Xu B, Zang SC, Lang LM, Lian S, Lu J, Li SZ, Yang HM, Zhen L
Journal of animal physiology and animal nutrition 2020 Nov;104(6):1948-1959
Journal of animal physiology and animal nutrition 2020 Nov;104(6):1948-1959
Two resveratrol analogs, pinosylvin and 4,4'-dihydroxystilbene, improve oligoasthenospermia in a mouse model by attenuating oxidative stress via the Nrf2-ARE pathway.
Wang CN, Sang MM, Gong SN, Yang JF, Cheng CY, Sun F
Bioorganic chemistry 2020 Nov;104:104295
Bioorganic chemistry 2020 Nov;104:104295
Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice.
Tamatam CM, Reddy NM, Potteti HR, Ankireddy A, Noone PM, Yamamoto M, Kensler TW, Reddy SP
Scientific reports 2020 Nov 4;10(1):19034
Scientific reports 2020 Nov 4;10(1):19034
Anthocyanins decrease the internalization of TiO(2) nanoparticles into 3D Caco-2 spheroids.
Wang J, Zhang J, Li S, Huang C, Xie Y, Cao Y
Food chemistry 2020 Nov 30;331:127360
Food chemistry 2020 Nov 30;331:127360
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Ding S, Ma N, Liu H, Tang M, Mei J
Aging 2020 Nov 24;12(24):25505-25527
Aging 2020 Nov 24;12(24):25505-25527
Mutual antagonism between indoleamine 2,3-dioxygenase 1 and nuclear factor E2-related factor 2 regulates the maturation status of DCs in liver fibrosis.
Mo C, Xie S, Zhong W, Zeng T, Huang S, Lai Y, Deng G, Zhou C, Yan W, Chen Y, Huang S, Gao L, Lv Z
Free radical biology & medicine 2020 Nov 20;160:178-190
Free radical biology & medicine 2020 Nov 20;160:178-190
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Cell death & disease 2020 Nov 17;11(11):991
Cell death & disease 2020 Nov 17;11(11):991
Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis.
Liu Z, Lv X, Song E, Song Y
Toxicology and applied pharmacology 2020 Nov 15;407:115241
Toxicology and applied pharmacology 2020 Nov 15;407:115241
Hesperidin ameliorates hypobaric hypoxia-induced retinal impairment through activation of Nrf2/HO-1 pathway and inhibition of apoptosis.
Xin X, Li Y, Liu H
Scientific reports 2020 Nov 10;10(1):19426
Scientific reports 2020 Nov 10;10(1):19426
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, Yang L
Journal of food biochemistry 2020 May;44(5):e13180
Journal of food biochemistry 2020 May;44(5):e13180
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways.
Shen B, Feng H, Cheng J, Li Z, Jin M, Zhao L, Wang Q, Qin H, Liu G
Journal of cellular and molecular medicine 2020 May;24(9):5097-5108
Journal of cellular and molecular medicine 2020 May;24(9):5097-5108
Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury.
Cheng P, Liu H, Li Y, Pi P, Jiang Y, Zang S, Li X, Fu A, Ren X, Xu J, Holmgren A, Lu J
Biochemical pharmacology 2020 May;175:113873
Biochemical pharmacology 2020 May;175:113873
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
Yu YP, Cai LC, Wang XY, Cheng SY, Zhang DM, Jian WG, Wang TD, Yang JK, Yang KB, Zhang C
Cancer science 2020 May;111(5):1555-1566
Cancer science 2020 May;111(5):1555-1566
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, Mao A, Zhu M
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation.
Wu Y, Jin Y, Sun T, Zhu P, Li J, Zhang Q, Wang X, Jiang J, Chen G, Zhao X
Journal of nanobiotechnology 2020 May 19;18(1):77
Journal of nanobiotechnology 2020 May 19;18(1):77
Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds.
Castiglione GM, Xu Z, Zhou L, Duh EJ
Nature communications 2020 May 18;11(1):2476
Nature communications 2020 May 18;11(1):2476
Anti-Inflammatory Effects of Lasia spinosa Leaf Extract in Lipopolysaccharide-Induced RAW 264.7 Macrophages.
Nguyen TQC, Duy Binh T, Pham TLA, Nguyen YDH, Thi Xuan Trang D, Nguyen TT, Kanaori K, Kamei K
International journal of molecular sciences 2020 May 13;21(10)
International journal of molecular sciences 2020 May 13;21(10)
Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions.
Magierowska K, Bakalarz D, Wójcik D, Korbut E, Danielak A, Głowacka U, Pajdo R, Buszewicz G, Ginter G, Surmiak M, Kwiecień S, Chmura A, Magierowski M, Brzozowski T
Cells 2020 May 12;9(5)
Cells 2020 May 12;9(5)
Spinosin Inhibits Aβ(1-42) Production and Aggregation via Activating Nrf2/HO-1 Pathway.
Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y
Biomolecules & therapeutics 2020 May 1;28(3):259-266
Biomolecules & therapeutics 2020 May 1;28(3):259-266
6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway.
Hong MK, Hu LL, Zhang YX, Xu YL, Liu XY, He PK, Jia YH
International immunopharmacology 2020 Mar;80:106196
International immunopharmacology 2020 Mar;80:106196
Mesenchymal stromal cells ameliorate acute lung injury induced by LPS mainly through stanniocalcin-2 mediating macrophage polarization.
Lv H, Liu Q, Sun Y, Yi X, Wei X, Liu W, Zhang Q, Yi H, Chen G
Annals of translational medicine 2020 Mar;8(6):334
Annals of translational medicine 2020 Mar;8(6):334
NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes.
Oksanen M, Hyötyläinen I, Trontti K, Rolova T, Wojciechowski S, Koskuvi M, Viitanen M, Levonen AL, Hovatta I, Roybon L, Lehtonen Š, Kanninen KM, Hämäläinen RH, Koistinaho J
Glia 2020 Mar;68(3):589-599
Glia 2020 Mar;68(3):589-599
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Xiao T, Sun J, Xing Z, Xie F, Yang L, Ding W
Cell biology international 2020 Mar;44(3):821-829
Cell biology international 2020 Mar;44(3):821-829
Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice.
Huang M, Wang Q, Long F, Di Y, Wang J, Zhun Zhu Y, Liu X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4107-4119
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4107-4119
Nardosinanone N suppresses LPS-induced macrophage activation by modulating the Nrf2 pathway and mPGES-1.
Lio CK, Luo JF, Shen XY, Dai Y, Machado J, Xie Y, Yao YD, Yu Y, Liu JX, Yao XS, Luo P, Zhou H
Biochemical pharmacology 2020 Mar;173:113639
Biochemical pharmacology 2020 Mar;173:113639
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
Zhu M, Liu H, Sun K, Liu J, Mou Y, Qi D, Zhou C, Abudunaibi M, Tasiken B, Li J, Cheng H, Huang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCF(β-TRCP)-Mediated Degradation of NRF2 in Pancreatic Cancer.
Yang Q, Li K, Huang X, Zhao C, Mei Y, Li X, Jiao L, Yang H
Molecular therapy. Nucleic acids 2020 Mar 6;19:974-985
Molecular therapy. Nucleic acids 2020 Mar 6;19:974-985
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Yao X, Yu S, Jing X, Guo J, Sun K, Guo F, Ye Y
Stem cell research & therapy 2020 Mar 30;11(1):140
Stem cell research & therapy 2020 Mar 30;11(1):140
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Lin Z, Fu C, Yan Z, Wu Y, Zhan J, Lou Z, Liao X, Pan J
Food & function 2020 Mar 26;11(3):2654-2666
Food & function 2020 Mar 26;11(3):2654-2666
Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway.
Zhang L, Zhang J, Yan E, He J, Zhong X, Zhang L, Wang C, Wang T
Animals : an open access journal from MDPI 2020 Mar 24;10(3)
Animals : an open access journal from MDPI 2020 Mar 24;10(3)
Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation.
Sun ZM, Guan P, Luo LF, Qin LY, Wang N, Zhao YS, Ji ES
Life sciences 2020 Mar 15;245:117362
Life sciences 2020 Mar 15;245:117362
Polydatin ameliorates chemotherapy-induced cognitive impairment (chemobrain) by inhibiting oxidative stress, inflammatory response, and apoptosis in rats.
Tong Y, Wang K, Sheng S, Cui J
Bioscience, biotechnology, and biochemistry 2020 Jun;84(6):1201-1210
Bioscience, biotechnology, and biochemistry 2020 Jun;84(6):1201-1210
HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.
Yang X, Ji J, Liu C, Zhou M, Li H, Ye S, Hu Q
International immunopharmacology 2020 Jun;83:106383
International immunopharmacology 2020 Jun;83:106383
Sulforaphane reduces intracellular survival of Staphylococcus aureus in macrophages through inhibition of JNK and p38 MAPK‑induced inflammation.
Deramaudt TB, Ali M, Vinit S, Bonay M
International journal of molecular medicine 2020 Jun;45(6):1927-1941
International journal of molecular medicine 2020 Jun;45(6):1927-1941
Exogenous Hydrogen Sulfide Regulates Mycoplasma pneumoniae Lipid-Associated Membrane Proteins to Induce Expression of Heme Oxygenase-1 and Proinflammatory Cytokines.
Hu X, Zeng W, You X, Ding W, Liu P, Chen L, Zeng Y, Zhu C
Inflammation 2020 Jun;43(3):847-856
Inflammation 2020 Jun;43(3):847-856
Protective effect of apigenin on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation.
Zhou RJ, Zhao Y, Fan K, Xie ML
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jun;393(6):929-936
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jun;393(6):929-936
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Li H, Liang M, Wang Z, Zhang Y, Wu Q, Yang L
Journal of medicinal food 2020 Jun;23(6):565-574
Journal of medicinal food 2020 Jun;23(6):565-574
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Liu J, Tan Y, Yang B, Wu Y, Fan B, Zhu S, Song E, Song Y
Environment international 2020 Jun;139:105701
Environment international 2020 Jun;139:105701
Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways.
Jin W, Xue Y, Xue Y, Han X, Song Q, Zhang J, Li Z, Cheng J, Guan S, Sun S, Chu L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110047
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110047
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Chen X, Yang JL, Chen YY, Mao QS, Xue WJ
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
You R, Zhou W, Li Y, Zhang Y, Huang S, Jia Z, Zhang A
Clinical science (London, England : 1979) 2020 Jun 26;134(12):1357-1376
Clinical science (London, England : 1979) 2020 Jun 26;134(12):1357-1376
Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.
Lazzara PR, David BP, Ankireddy A, Richardson BG, Dye K, Ratia KM, Reddy SP, Moore TW
Journal of medicinal chemistry 2020 Jun 25;63(12):6547-6560
Journal of medicinal chemistry 2020 Jun 25;63(12):6547-6560
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Wang Y, Li C, Li J, Wang G, Li L
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.
Fan Y, Xing Y, Xiong L, Wang J
Chemico-biological interactions 2020 Jun 1;324:109086
Chemico-biological interactions 2020 Jun 1;324:109086
Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice.
Zhao X, Liu Z, Gao J, Li H, Wang X, Li Y, Sun F
Toxicology 2020 Jul;440:152489
Toxicology 2020 Jul;440:152489
Stomatin-like protein-2 confers neuroprotection effect in oxygen-glucose deprivation/reoxygenation-injured neurons by regulating AMPK/Nrf2 signalling.
Wang M, Li C, Shi W
Journal of drug targeting 2020 Jul;28(6):600-608
Journal of drug targeting 2020 Jul;28(6):600-608
MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells.
Bai T, Liang R, Zhu R, Wang W, Zhou L, Sun Y
Journal of cellular physiology 2020 Jul;235(7-8):5637-5648
Journal of cellular physiology 2020 Jul;235(7-8):5637-5648
Luteolin alleviates ochratoxin A induced oxidative stress by regulating Nrf2 and HIF-1α pathways in NRK-52E rat kidney cells.
Liu M, Cheng C, Li X, Zhou S, Hua J, Huang J, Li Y, Yang K, Zhang P, Zhang Y, Tian J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Jul;141:111436
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Jul;141:111436
Downregulation of RKIP promotes radioresistance of nasopharyngeal carcinoma by activating NRF2/NQO1 axis via downregulating miR-450b-5p.
Huang W, Shi G, Yong Z, Li J, Qiu J, Cao Y, Zhao Y, Yuan L
Cell death & disease 2020 Jul 6;11(7):504
Cell death & disease 2020 Jul 6;11(7):504
Piceatannol Ameliorates Hepatic Oxidative Damage and Mitochondrial Dysfunction of Weaned Piglets Challenged with Diquat.
Jia P, Ji S, Zhang H, Chen Y, Wang T
Animals : an open access journal from MDPI 2020 Jul 21;10(7)
Animals : an open access journal from MDPI 2020 Jul 21;10(7)
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Jasek-Gajda E, Jurkowska H, Jasińska M, Lis GJ
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Xie C, Ge M, Jin J, Xu H, Mao L, Geng S, Wu J, Zhu J, Li X, Zhong C
Journal of hazardous materials 2020 Jul 15;394:122549
Journal of hazardous materials 2020 Jul 15;394:122549
Hydrogen gas protects against delayed encephalopathy after acute carbon monoxide poisoning in a rat model.
Shen M, Zheng Y, Zhu K, Cai Z, Liu W, Sun X, Liu J, Zhu D
Neurological research 2020 Jan;42(1):22-30
Neurological research 2020 Jan;42(1):22-30
Inhibition of the Keap1-Nrf2 protein-protein interaction protects retinal cells and ameliorates retinal ischemia-reperfusion injury.
Hui Q, Karlstetter M, Xu Z, Yang J, Zhou L, Eilken HM, Terjung C, Cho H, Gong J, Lai MJ, Nassar K, Duh EJ
Free radical biology & medicine 2020 Jan;146:181-188
Free radical biology & medicine 2020 Jan;146:181-188
The expression of p-p62 and nuclear Nrf2 in esophageal squamous cell carcinoma and association with radioresistance.
Wang Z, Zhang J, Li M, Kong L, Yu J
Thoracic cancer 2020 Jan;11(1):130-139
Thoracic cancer 2020 Jan;11(1):130-139
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Dong Y, Xing Y, Sun J, Sun W, Xu Y, Quan C
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
HIPK2 overexpression relieves hypoxia/reoxygenation-induced apoptosis and oxidative damage of cardiomyocytes through enhancement of the Nrf2/ARE signaling pathway.
Dang X, Zhang R, Peng Z, Qin Y, Sun J, Niu Z, Pei H
Chemico-biological interactions 2020 Jan 25;316:108922
Chemico-biological interactions 2020 Jan 25;316:108922
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
Xu Q, Shi W, Lv P, Meng W, Mao G, Gong C, Chen Y, Wei Y, He X, Zhao J, Han H, Sun M, Xiao K
Cell death & disease 2020 Jan 2;11(1):6
Cell death & disease 2020 Jan 2;11(1):6
TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway.
Liu Y, Tao S, Liao L, Li Y, Li H, Li Z, Lin L, Wan X, Yang X, Chen L
Nature communications 2020 Jan 17;11(1):348
Nature communications 2020 Jan 17;11(1):348
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.
Xu A, Yang Y, Shao Y, Wu M, Sun Y
Cell communication and signaling : CCS 2020 Jan 15;18(1):9
Cell communication and signaling : CCS 2020 Jan 15;18(1):9
Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries.
Liang LY, Wang MM, Liu M, Zhao W, Wang X, Shi L, Zhu MJ, Zhao YL, Liu L, Maurya P, Wang Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Feb;62:104668
Toxicology in vitro : an international journal published in association with BIBRA 2020 Feb;62:104668
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Hang H, Wang LK, Ren SY, Song AJ, Wu GF
Current medical science 2020 Feb;40(1):55-62
Current medical science 2020 Feb;40(1):55-62
Protective effect of Liraglutide on diabetic retinal neurodegeneration via inhibiting oxidative stress and endoplasmic reticulum stress.
Liu J, Wei L, Wang Z, Song S, Lin Z, Zhu J, Ren X, Kong L
Neurochemistry international 2020 Feb;133:104624
Neurochemistry international 2020 Feb;133:104624
Evaluation and Exploration of Potentially Bioactive Peptides in Casein Hydrolysates against Liver Oxidative Damage in STZ/HFD-Induced Diabetic Rats.
Wang C, Zheng L, Su G, Zeng XA, Sun B, Zhao M
Journal of agricultural and food chemistry 2020 Feb 26;68(8):2393-2405
Journal of agricultural and food chemistry 2020 Feb 26;68(8):2393-2405
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Liu H, Zhu Y, Gao Y, Qi D, Zhao L, Zhao L, Liu C, Tao T, Zhou C, Sun X, Guo F, Xiao J
Cell death & disease 2020 Feb 18;11(2):129
Cell death & disease 2020 Feb 18;11(2):129
Syringin protects against colitis by ameliorating inflammation.
Zhang H, Gu H, Jia Q, Zhao Y, Li H, Shen S, Liu X, Wang G, Shi Q
Archives of biochemistry and biophysics 2020 Feb 15;680:108242
Archives of biochemistry and biophysics 2020 Feb 15;680:108242
Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress.
Zhang Y, Wang H, Zhang L, Yuan Y, Yu D
International journal of biological macromolecules 2020 Feb 15;145:944-949
International journal of biological macromolecules 2020 Feb 15;145:944-949
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H(2)O(2)-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
Qi L, Jiang J, Zhang J, Zhang L, Wang T
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Shopit A, Niu M, Wang H, Tang Z, Li X, Tesfaldet T, Ai J, Ahmad N, Al-Azab M, Tang Z
Life sciences 2020 Feb 1;242:117248
Life sciences 2020 Feb 1;242:117248
Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice.
Zang H, Wu W, Qi L, Tan W, Nagarkatti P, Nagarkatti M, Wang X, Cui T
Diabetes 2020 Dec;69(12):2720-2734
Diabetes 2020 Dec;69(12):2720-2734
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl(4)-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Zhang X, Feng J, Su S, Huang L
Pharmaceutical biology 2020 Dec;58(1):239-246
Pharmaceutical biology 2020 Dec;58(1):239-246
Oxidative stress-mediated hepatotoxicity in rats induced by ethanol extracts of different parts of Chloranthus serratus.
Sun S, Wang Y, Du Y, Sun Q, He L, Zhu E, Li J
Pharmaceutical biology 2020 Dec;58(1):1277-1289
Pharmaceutical biology 2020 Dec;58(1):1277-1289
Resveratrol improves meat quality, muscular antioxidant capacity, lipid metabolism and fiber type composition of intrauterine growth retarded pigs.
Cheng K, Yu C, Li Z, Li S, Yan E, Song Z, Zhang H, Zhang L, Wang T
Meat science 2020 Dec;170:108237
Meat science 2020 Dec;170:108237
Functional Food XingJiuTang Attenuates Alcohol-Induced Liver Injury by Regulating SIRT1/Nrf-2 Signaling Pathway.
Hao J, Ding Y, Shi W, Zhang C, Li R
Chemistry & biodiversity 2020 Dec;17(12):e2000619
Chemistry & biodiversity 2020 Dec;17(12):e2000619
Curcumin-cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress.
Caillaud M, Msheik Z, Ndong-Ntoutoume GM, Vignaud L, Richard L, Favreau F, Faye PA, Sturtz F, Granet R, Vallat JM, Sol V, Desmoulière A, Billet F
Free radical biology & medicine 2020 Dec;161:246-262
Free radical biology & medicine 2020 Dec;161:246-262
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Guo H, Wang Y, Liu D
Acta histochemica 2020 Dec;122(8):151620
Acta histochemica 2020 Dec;122(8):151620
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.
You L, Chen J, Liu W, Xiang Q, Luo Z, Wang W, Xu W, Wu K, Zhang Q, Liu Y, Wu J
Virulence 2020 Dec;11(1):537-553
Virulence 2020 Dec;11(1):537-553
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis.
Yi J, Zhu J, Wu J, Thompson CB, Jiang X
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 8;117(49):31189-31197
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 8;117(49):31189-31197
Hylocereus polyrhizus Peel Extract Retards Alcoholic Liver Disease Progression by Modulating Oxidative Stress and Inflammatory Responses in C57BL/6 Mice.
Yeh WJ, Tsai CC, Ko J, Yang HY
Nutrients 2020 Dec 18;12(12)
Nutrients 2020 Dec 18;12(12)
TRIM16 protects human periodontal ligament stem cells from oxidative stress-induced damage via activation of PICOT.
Zhao Y, Liu H, Xi X, Chen S, Liu D
Experimental cell research 2020 Dec 1;397(1):112336
Experimental cell research 2020 Dec 1;397(1):112336
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
Li Z, Lian Y, Wei R, Jin L, Cao H, Zhao T, Ma X, Zhong M, Gao Y, Zhang K
Life sciences 2020 Dec 1;262:118546
Life sciences 2020 Dec 1;262:118546
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
Gu M, Jin J, Ren C, Chen X, Gao W, Wang X, Wu Y, Tian N, Pan Z, Wu A, Zhou Y, Zhang X
Food & function 2020 Dec 1;11(12):10852-10863
Food & function 2020 Dec 1;11(12):10852-10863
Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain.
Zhou YQ, Liu DQ, Chen SP, Chen N, Sun J, Wang XM, Cao F, Tian YK, Ye DW
Acta pharmacologica Sinica 2020 Aug;41(8):1041-1048
Acta pharmacologica Sinica 2020 Aug;41(8):1041-1048
Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.
Du J, Zhu M, Li H, Liang G, Li Y, Feng S
Experimental and therapeutic medicine 2020 Aug;20(2):838-845
Experimental and therapeutic medicine 2020 Aug;20(2):838-845
Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice.
Xie D, Jiang L, Lin Y, Liu Z
BMC complementary medicine and therapies 2020 Aug 27;20(1):264
BMC complementary medicine and therapies 2020 Aug 27;20(1):264
Effects of Launaea sarmentosa Extract on Lipopolysaccharide-Induced Inflammation via Suppression of NF-κB/MAPK Signaling and Nrf2 Activation.
Nguyen TQC, Binh TD, Kusunoki R, Pham TLA, Nguyen YDH, Nguyen TT, Kanaori K, Kamei K
Nutrients 2020 Aug 26;12(9)
Nutrients 2020 Aug 26;12(9)
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Zhang Y, Zhao S, Fu Y, Yan L, Feng Y, Chen Y, Wu Y, Deng Y, Zhang G, Chen Z, Chen Y, Liu T
Cell death & disease 2020 Aug 18;11(8):641
Cell death & disease 2020 Aug 18;11(8):641
Silychristin A activates Nrf2-HO-1/SOD2 pathway to reduce apoptosis and improve GLP-1 production through upregulation of estrogen receptor α in GLUTag cells.
Wang J, Zhang X, Zhang L, Yan T, Wu B, Xu F, Jia Y
European journal of pharmacology 2020 Aug 15;881:173236
European journal of pharmacology 2020 Aug 15;881:173236
l-Arginine Inhibits Apoptosis of Ovine Intestinal Epithelial Cells through the l-Arginine-Nitric Oxide Pathway.
Zhang H, Zhao F, Peng A, Guo S, Wang M, Elsabagh M, Loor JJ, Wang H
The Journal of nutrition 2020 Aug 1;150(8):2051-2060
The Journal of nutrition 2020 Aug 1;150(8):2051-2060
Dandelion Extract Alleviated Lipopolysaccharide-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.
Sun Y, Wu Y, Wang Z, Chen J, Yang Y, Dong G
Toxins 2020 Aug 1;12(8)
Toxins 2020 Aug 1;12(8)
Protective effect of Dioscorea zingiberensis ethanol extract on the disruption of blood-testes barrier in high-fat diet/streptozotocin-induced diabetic mice by upregulating ZO-1 and Nrf2.
Zhou J, Xi Y, Zhang J, Tang J, Zhou X, Chen J, Nie C, Zhu Z, Ma B
Andrologia 2020 Apr;52(3):e13508
Andrologia 2020 Apr;52(3):e13508
Long noncoding RNA TUG1 regulates prostate cancer cell proliferation, invasion and migration via the Nrf2 signaling axis.
Yang G, Yin H, Lin F, Gao S, Zhan K, Tong H, Tang X, Pan Q, Gou X
Pathology, research and practice 2020 Apr;216(4):152851
Pathology, research and practice 2020 Apr;216(4):152851
Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis.
Kuo PC, Weng WT, Scofield BA, Paraiso HC, Brown DA, Wang PY, Yu IC, Yen JH
Journal of neuroinflammation 2020 Apr 29;17(1):138
Journal of neuroinflammation 2020 Apr 29;17(1):138
4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease.
Yang WJ, Chen XM, Wang SQ, Hu HX, Cheng XP, Xu LT, Ren DM, Wang XN, Zhao BB, Lou HX, Shen T
Journal of natural products 2020 Apr 24;83(4):1217-1228
Journal of natural products 2020 Apr 24;83(4):1217-1228
Maternal curcumin supplementation ameliorates placental function and fetal growth in mice with intrauterine growth retardation†.
Qi L, Jiang J, Zhang J, Zhang L, Wang T
Biology of reproduction 2020 Apr 24;102(5):1090-1101
Biology of reproduction 2020 Apr 24;102(5):1090-1101
Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses.
Jiang Z, Fu L, Xu Y, Hu X, Yang H, Zhang Y, Luo H, Gan S, Tao L, Liang G, Shen X
Scientific reports 2020 Apr 14;10(1):6427
Scientific reports 2020 Apr 14;10(1):6427
Compensatory upregulation of aldo-keto reductase 1B10 to protect hepatocytes against oxidative stress during hepatocarcinogenesis.
Liu Y, Zhang J, Liu H, Guan G, Zhang T, Wang L, Qi X, Zheng H, Chen CC, Liu J, Cao D, Lu F, Chen X
American journal of cancer research 2019;9(12):2730-2748
American journal of cancer research 2019;9(12):2730-2748
SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway.
Sun X, Wang S, Gai J, Guan J, Li J, Li Y, Zhao J, Zhao C, Fu L, Li Q
Frontiers in oncology 2019;9:754
Frontiers in oncology 2019;9:754
Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells.
Li Y, Guo Y, Feng Z, Bergan R, Li B, Qin Y, Zhao L, Zhang Z, Shi M
Nutrition and cancer 2019;71(6):1007-1018
Nutrition and cancer 2019;71(6):1007-1018
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X
Oxidative medicine and cellular longevity 2019;2019:8564681
Oxidative medicine and cellular longevity 2019;2019:8564681
Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway.
Liao HH, Zhang N, Meng YY, Feng H, Yang JJ, Li WJ, Chen S, Wu HM, Deng W, Tang QZ
Oxidative medicine and cellular longevity 2019;2019:6304058
Oxidative medicine and cellular longevity 2019;2019:6304058
CCl(4)-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Peng C, Zhou ZM, Li J, Luo Y, Zhou YS, Ke XH, Huang KE
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Zhao K, Li Y, Wang Z, Han N, Wang Y
BioMed research international 2019;2019:4348973
BioMed research international 2019;2019:4348973
Effects of Ethyl Pyruvate on Bile Duct Ligation-Induced Liver Fibrosis by Regulating Nrf2 Pathway and Proinflammatory Cytokines in Rats.
Zong Y, Zhang M, Li S, Qi W, Li J, Liu T, Yang H, Lu C, Hu X
Gastroenterology research and practice 2019;2019:2969802
Gastroenterology research and practice 2019;2019:2969802
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Zhang HF, Wang JH, Wang YL, Gao C, Gu YT, Huang J, Wang JH, Zhang Z
Oxidative medicine and cellular longevity 2019;2019:2853534
Oxidative medicine and cellular longevity 2019;2019:2853534
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
Yan X, Fu X, Jia Y, Ma X, Tao J, Yang T, Ma H, Liang X, Liu X, Yang J, Wei J
Oxidative medicine and cellular longevity 2019;2019:2654910
Oxidative medicine and cellular longevity 2019;2019:2654910
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Liu Y, Zhang S, Xue J, Wei Z, Ao P, Shen B, Ding L
Oxidative medicine and cellular longevity 2019;2019:2053149
Oxidative medicine and cellular longevity 2019;2019:2053149
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B, Chen X
Frontiers in pharmacology 2019;10:1030
Frontiers in pharmacology 2019;10:1030
Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.
Zhang C, Zhan J, Zhao M, Dai H, Deng Y, Zhou W, Zhao L
Neurotoxicology 2019 Sep;74:74-80
Neurotoxicology 2019 Sep;74:74-80
Ellagic acid supports neuron by regulating astroglia Nrf2.
Wang GQ, He XM, Zhu GF, Li DD, Shi JS, Zhang F
Biotechnology and applied biochemistry 2019 Sep;66(5):738-743
Biotechnology and applied biochemistry 2019 Sep;66(5):738-743
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
Li AL, Shen T, Wang T, Zhou MX, Wang B, Song JT, Zhang PL, Wang XL, Ren DM, Lou HX, Wang XN
Free radical biology & medicine 2019 Sep;141:21-33
Free radical biology & medicine 2019 Sep;141:21-33
Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway.
Wang Y, Zuo R, Wang Z, Luo L, Wu J, Zhang C, Liu M, Shi C, Zhou Y
Aging 2019 Sep 23;11(18):7961-7977
Aging 2019 Sep 23;11(18):7961-7977
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M
Marine drugs 2019 Sep 20;17(10)
Marine drugs 2019 Sep 20;17(10)
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Jing L, Jiang JR, Liu DM, Sheng JW, Zhang WF, Li ZJ, Wei LY
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Lysosomal dysfunction is associated with persistent lung injury in dams caused by pregnancy exposure to carbon black nanoparticles.
Liu X, Tu B, Jiang X, Xu G, Bai L, Zhang L, Meng P, Qin X, Chen C, Zou Z
Life sciences 2019 Sep 15;233:116741
Life sciences 2019 Sep 15;233:116741
Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo.
Liu C, Cui Y, Pi F, Guo Y, Cheng Y, Qian H
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10059-10068
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10059-10068
Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2-HMOX1 axis.
Liu X, Song Z, Bai J, Nauwynck H, Zhao Y, Jiang P
Veterinary research 2019 Sep 11;50(1):61
Veterinary research 2019 Sep 11;50(1):61
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
Wu XY, Chen XM, Zhou MX, Hu HX, Zhang JZ, Wang XN, Ren DM, Lou HX, Shen T
Chemico-biological interactions 2019 Sep 1;310:108741
Chemico-biological interactions 2019 Sep 1;310:108741
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Liang M, Li H, Wang Z, Cai L, Yang L
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Gao W, Wang W, Zhang J, Deng P, Hu J, Yang J, Deng Z
Metabolic brain disease 2019 Oct;34(5):1267-1280
Metabolic brain disease 2019 Oct;34(5):1267-1280
Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress.
Xie YK, Zhou X, Yuan HT, Qiu J, Xin DQ, Chu XL, Wang DC, Wang Z
Neural regeneration research 2019 Oct;14(10):1734-1742
Neural regeneration research 2019 Oct;14(10):1734-1742
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
Lu Q, Tan S, Gu W, Li F, Hua W, Zhang S, Chen F, Tang L
Journal of ethnopharmacology 2019 Oct 28;243:112089
Journal of ethnopharmacology 2019 Oct 28;243:112089
Botrysphin D attenuates arsenic-induced oxidative stress in human lung epithelial cells via activating Nrf2/ARE signaling pathways.
Wang T, Sun XY, Li AL, Zhou MX, Han Y, Zhang JZ, Ren DM, Lou HX, Wang XN, Shen T
Biochemical and biophysical research communications 2019 Oct 20;518(3):526-532
Biochemical and biophysical research communications 2019 Oct 20;518(3):526-532
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Shu G, Qiu Y, Hao J, Fu Q, Deng X
Food & function 2019 Oct 16;10(10):6858-6872
Food & function 2019 Oct 16;10(10):6858-6872
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Yang HM, Li SZ
Brain sciences 2019 Oct 12;9(10)
Brain sciences 2019 Oct 12;9(10)
Neuroprotection of Andrographolide Against Microglia-Mediated Inflammatory Injury and Oxidative Damage in PC12 Neurons.
Xu Y, Tang D, Wang J, Wei H, Gao J
Neurochemical research 2019 Nov;44(11):2619-2630
Neurochemical research 2019 Nov;44(11):2619-2630
Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss.
Menale C, Robinson LJ, Palagano E, Rigoni R, Erreni M, Almarza AJ, Strina D, Mantero S, Lizier M, Forlino A, Besio R, Monari M, Vezzoni P, Cassani B, Blair HC, Villa A, Sobacchi C
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Nov;34(11):2133-2148
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Nov;34(11):2133-2148
The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.
Yao B, He J, Yin X, Shi Y, Wan J, Tian Z
Toxicology letters 2019 Nov;316:109-118
Toxicology letters 2019 Nov;316:109-118
MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
Zhang J, Cai W, Fan Z, Yang C, Wang W, Xiong M, Ma C, Yang J
Atherosclerosis 2019 Nov;290:9-18
Atherosclerosis 2019 Nov;290:9-18
The roles of Nrf2 and autophagy in modulating inflammation mediated by TLR4 - NFκB in A549 cell exposed to layer house particulate matter 2.5 (PM(2.5)).
Dai P, Shen D, Shen J, Tang Q, Xi M, Li Y, Li C
Chemosphere 2019 Nov;235:1134-1145
Chemosphere 2019 Nov;235:1134-1145
Spinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats.
Gu M, He P, Lyu C, Liu X, Xu Y, Cheng S, Gu Y, Jia Y
Molecular medicine reports 2019 Nov;20(5):4253-4261
Molecular medicine reports 2019 Nov;20(5):4253-4261
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation.
Zhu J, Berisa M, Schwörer S, Qin W, Cross JR, Thompson CB
Cell metabolism 2019 Nov 5;30(5):865-876.e5
Cell metabolism 2019 Nov 5;30(5):865-876.e5
Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis.
Sun K, Luo J, Jing X, Guo J, Yao X, Hao X, Ye Y, Liang S, Lin J, Wang G, Guo F
Aging 2019 Nov 26;11(22):10513-10531
Aging 2019 Nov 26;11(22):10513-10531
Chitosan Oligosaccharide Attenuates Nonalcoholic Fatty Liver Disease Induced by High Fat Diet through Reducing Lipid Accumulation, Inflammation and Oxidative Stress in C57BL/6 Mice.
Tao W, Sun W, Liu L, Wang G, Xiao Z, Pei X, Wang M
Marine drugs 2019 Nov 16;17(11)
Marine drugs 2019 Nov 16;17(11)
Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1.
Cheng FY, Lee YH, Hsu YH, Chiu IJ, Chiu YJ, Lin YF, Chiu HW
Aging 2019 Nov 12;11(21):9875-9892
Aging 2019 Nov 12;11(21):9875-9892
Protective effect of dihydroartemisinin in inhibiting senescence of myeloid-derived suppressor cells from lupus mice via Nrf2/HO-1 pathway.
Li D, Qi J, Wang J, Pan Y, Li J, Xia X, Dou H, Hou Y
Free radical biology & medicine 2019 Nov 1;143:260-274
Free radical biology & medicine 2019 Nov 1;143:260-274
S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.
Tocmo R, Parkin K
Free radical biology & medicine 2019 Nov 1;143:164-175
Free radical biology & medicine 2019 Nov 1;143:164-175
The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice.
Liao Z, Zhang J, Wang J, Yan T, Xu F, Wu B, Xiao F, Bi K, Niu J, Jia Y
International journal of biological macromolecules 2019 Nov 1;140:568-576
International journal of biological macromolecules 2019 Nov 1;140:568-576
Hydrogen sulfide ameliorates disorders in the parafacial respiratory group region of neonatal rats caused by prenatal cigarette smoke exposure via an antioxidative effect.
Yan X, Zhao F, Zhang S, Lei F, Wang W, Zheng Y
Environmental toxicology and pharmacology 2019 May;68:80-90
Environmental toxicology and pharmacology 2019 May;68:80-90
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
Sparaneo A, Fabrizio FP, la Torre A, Graziano P, Di Maio M, Fontana A, Bisceglia M, Rossi A, Pizzolitto S, De Maglio G, Tancredi A, Grimaldi F, Balsamo T, Centra F, Manzorra MC, Trombetta D, Pantalone A, Bonfitto A, Maiello E, Fazio VM, Muscarella LA
International journal of molecular sciences 2019 May 23;20(10)
International journal of molecular sciences 2019 May 23;20(10)
Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model.
Liao Z, Zhang J, Liu B, Yan T, Xu F, Xiao F, Wu B, Bi K, Jia Y
Molecules (Basel, Switzerland) 2019 May 17;24(10)
Molecules (Basel, Switzerland) 2019 May 17;24(10)
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Yang P, Zhou Y, Xia Q, Yao L, Chang X
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation.
Hu Y, Wang Y, Yan T, Feng D, Ba Y, Zhang H, Zhu J, Cheng X, Cui L, Huang H
Reproductive toxicology (Elmsford, N.Y.) 2019 Mar;84:98-107
Reproductive toxicology (Elmsford, N.Y.) 2019 Mar;84:98-107
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signalling pathway and prevents oxidative insults in human lung epithelial cells.
Yang WJ, He JX, Zhou MX, Huang M, Wang SQ, Wang XN, Lou HX, Ren DM, Shen T
Free radical research 2019 Mar;53(3):348-358
Free radical research 2019 Mar;53(3):348-358
Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production.
Li C, Wang Y, Li L, Han Z, Mao S, Wang G
Cell stress & chaperones 2019 Mar;24(2):453-460
Cell stress & chaperones 2019 Mar;24(2):453-460
Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway.
Zhong L, Hao H, Chen D, Hou Q, Zhu Z, He W, Sun S, Sun M, Li M, Fu X
Journal of cellular physiology 2019 Mar;234(3):2606-2617
Journal of cellular physiology 2019 Mar;234(3):2606-2617
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L
International journal of molecular sciences 2019 Mar 6;20(5)
International journal of molecular sciences 2019 Mar 6;20(5)
Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β(1)/Smad(2)/Nrf(2)-NOX(4) signaling pathways.
Liu B, Rong Y, Sun D, Li W, Chen H, Cao B, Wang T
Biochemical and biophysical research communications 2019 Mar 5;510(2):329-333
Biochemical and biophysical research communications 2019 Mar 5;510(2):329-333
Neuroprotective Effect of Dioscin on the Aging Brain.
Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Synthesis and biological activities of petrosiols B and D.
Geng J, Ren Q, Chang C, Xie X, Liu J, Du Y
RSC advances 2019 Mar 28;9(18):10253-10263
RSC advances 2019 Mar 28;9(18):10253-10263
Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells.
Zuo R, Wang Y, Li J, Wu J, Wang W, Li B, Sun C, Wang Z, Shi C, Zhou Y, Liu M, Zhang C
Stem cells (Dayton, Ohio) 2019 Jun;37(6):828-840
Stem cells (Dayton, Ohio) 2019 Jun;37(6):828-840
Inhibition of SGK1 confers vulnerability to redox dysregulation in cervical cancer.
Wang M, Xue Y, Shen L, Qin P, Sang X, Tao Z, Yi J, Wang J, Liu P, Cheng H
Redox biology 2019 Jun;24:101225
Redox biology 2019 Jun;24:101225
Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome.
Qin M, Long F, Wu W, Yang D, Huang M, Xiao C, Chen X, Liu X, Zhu YZ
Free radical biology & medicine 2019 Jun;137:99-109
Free radical biology & medicine 2019 Jun;137:99-109
Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions.
Ren L, Zhan P, Wang Q, Wang C, Liu Y, Yu Z, Zhang S
Biochemical and biophysical research communications 2019 Jun 30;514(3):691-698
Biochemical and biophysical research communications 2019 Jun 30;514(3):691-698
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Yan J, Pang Y, Zhuang J, Lin H, Zhang Q, Han L, Ke P, Zhuang J, Huang X
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Zhou W, Ma L, Ding L, Guo Q, He Z, Yang J, Qiao H, Li L, Yang J, Yu S, Zhao L, Wang S, Liu HM, Suo Z, Zhao W
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.
Yamada M, Iwata M, Warabi E, Oishi H, Lira VA, Okutsu M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8022-8032
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8022-8032
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Liu H, Dong Y, Gao Y, Zhao L, Cai C, Qi D, Zhu M, Zhao L, Liu C, Guo F, Xiao J, Huang H
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Yang Y, Chen S, Tao L, Gan S, Luo H, Xu Y, Shen X
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway.
Lan H, Su Y, Liu Y, Deng C, Wang J, Chen T, Jules KED, Masau JF, Li H, Wei X
Life sciences 2019 Jul 1;228:35-46
Life sciences 2019 Jul 1;228:35-46
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Yang Q, Lin J, Zhang H, Liu Y, Kan M, Xiu Z, Chen X, Lan X, Li X, Shi X, Li N, Qu X
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats.
Chen ZJ, Chen JX, Wu LK, Li BY, Tian YF, Xian M, Huang ZP, Yu RA
Biomedical and environmental sciences : BES 2019 Jan;32(1):1-10
Biomedical and environmental sciences : BES 2019 Jan;32(1):1-10
Naringenin targets on astroglial Nrf2 to support dopaminergic neurons.
Wang GQ, Zhang B, He XM, Li DD, Shi JS, Zhang F
Pharmacological research 2019 Jan;139:452-459
Pharmacological research 2019 Jan;139:452-459
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Song Q, Zhang Y, Han X, Zhang Y, Zhang X, Gao Y, Zhang J, Chu L, Zhao S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde.
Huang J, Lu Y, Zhang B, Yang S, Zhang Q, Cui H, Lu X, Zhao Y, Yang X, Li R
Toxicology 2019 Jan 15;412:29-36
Toxicology 2019 Jan 15;412:29-36
Differential response to lead toxicity in rat primary microglia and astrocytes.
Peng J, Zhou F, Wang Y, Xu Y, Zhang H, Zou F, Meng X
Toxicology and applied pharmacology 2019 Jan 15;363:64-71
Toxicology and applied pharmacology 2019 Jan 15;363:64-71
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Lei P, Tian S, Teng C, Huang L, Liu X, Wang J, Zhang Y, Li B, Shan Y
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z
Metabolic brain disease 2019 Feb;34(1):319-329
Metabolic brain disease 2019 Feb;34(1):319-329
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Li Y, Chen Y, Qiu C, Ma X, Lei K, Cai G, Liang X, Liu J
Journal of cellular biochemistry 2019 Feb;120(2):1560-1576
Journal of cellular biochemistry 2019 Feb;120(2):1560-1576
Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1β and promoting Nrf2/HO-1.
Song S, An J, Li Y, Liu S
Molecular immunology 2019 Feb;106:143-152
Molecular immunology 2019 Feb;106:143-152
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
Ullah O, Li Z, Ali I, Xu L, Liu H, Shah SZA, Fang N
The Journal of reproduction and development 2019 Feb 8;65(1):73-81
The Journal of reproduction and development 2019 Feb 8;65(1):73-81
Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary.
Akino N, Wada-Hiraike O, Isono W, Terao H, Honjo H, Miyamoto Y, Tanikawa M, Sone K, Hirano M, Harada M, Hirata T, Hirota Y, Koga K, Oda K, Fujii T, Osuga Y
Reproductive biology and endocrinology : RB&E 2019 Feb 13;17(1):23
Reproductive biology and endocrinology : RB&E 2019 Feb 13;17(1):23
Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor.
Sha J, Zhang H, Zhao Y, Feng X, Hu X, Wang C, Song M, Fan H
Toxicology and applied pharmacology 2019 Feb 1;364:144-152
Toxicology and applied pharmacology 2019 Feb 1;364:144-152
Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
Li L, Liu T, Liu L, Li S, Zhang Z, Zhang R, Zhou Y, Liu F
Journal of bioenergetics and biomembranes 2019 Dec;51(6):393-402
Journal of bioenergetics and biomembranes 2019 Dec;51(6):393-402
Punicalagin Reversed the Hepatic Injury of Tetrachloromethane by Antioxidation and Enhancement of Autophagy.
Luo J, Long Y, Ren G, Zhang Y, Chen J, Huang R, Yang L
Journal of medicinal food 2019 Dec;22(12):1271-1279
Journal of medicinal food 2019 Dec;22(12):1271-1279
Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer.
Magierowska K, Korbut E, Hubalewska-Mazgaj M, Surmiak M, Chmura A, Bakalarz D, Buszewicz G, Wójcik D, Śliwowski Z, Ginter G, Gromowski T, Kwiecień S, Brzozowski T, Magierowski M
Free radical biology & medicine 2019 Dec;145:198-208
Free radical biology & medicine 2019 Dec;145:198-208
Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling.
Wang Y, Jiang F, Cheng H, Tan X, Liu Y, Wei C, Song E
International journal of molecular sciences 2019 Dec 5;20(24)
International journal of molecular sciences 2019 Dec 5;20(24)
Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation.
Niu Y, He J, Ahmad H, Shen M, Zhao Y, Gan Z, Zhang L, Zhong X, Wang C, Wang T
Nutrients 2019 Dec 5;11(12)
Nutrients 2019 Dec 5;11(12)
Curcumin Alleviates IUGR Jejunum Damage by Increasing Antioxidant Capacity through Nrf2/Keap1 Pathway in Growing Pigs.
Yan E, Zhang J, Han H, Wu J, Gan Z, Wei C, Zhang L, Wang C, Wang T
Animals : an open access journal from MDPI 2019 Dec 24;10(1)
Animals : an open access journal from MDPI 2019 Dec 24;10(1)
Water-separated part of Chloranthus serratus alleviates lipopolysaccharide- induced RAW264.7 cell injury mainly by regulating the MAPK and Nrf2/HO-1 inflammatory pathways.
Sun S, Du Y, Yin C, Suo X, Wang R, Xia R, Zhang X
BMC complementary and alternative medicine 2019 Dec 2;19(1):343
BMC complementary and alternative medicine 2019 Dec 2;19(1):343
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.
Liu L, Chen H, Jin J, Tang Z, Yin P, Zhong D, Li G
Life sciences 2019 Dec 15;239:117036
Life sciences 2019 Dec 15;239:117036
Discovery of coumarin-derived imino sulfonates as a novel class of potential cardioprotective agents.
Wei B, Zhou J, Xu JJ, Cui J, Ping FF, Ling JJ, Chen YJ
European journal of medicinal chemistry 2019 Dec 15;184:111779
European journal of medicinal chemistry 2019 Dec 15;184:111779
Dietary Dihydroartemisinin Supplementation Attenuates Hepatic Oxidative Damage of Weaned Piglets with Intrauterine Growth Retardation through the Nrf2/ARE Signaling Pathway.
Zhao Y, Niu Y, He J, Zhang L, Wang C, Wang T
Animals : an open access journal from MDPI 2019 Dec 13;9(12)
Animals : an open access journal from MDPI 2019 Dec 13;9(12)
Protective Effects of Fucoidan against Hydrogen Peroxide-Induced Oxidative Damage in Porcine Intestinal Epithelial Cells.
Li Y, Zhao W, Wang L, Chen Y, Zhang H, Wang T, Yang X, Xing F, Yan J, Fang X
Animals : an open access journal from MDPI 2019 Dec 10;9(12)
Animals : an open access journal from MDPI 2019 Dec 10;9(12)
Icariin targets Nrf2 signaling to inhibit microglia-mediated neuroinflammation.
Zheng Y, Zhu G, He J, Wang G, Li D, Zhang F
International immunopharmacology 2019 Aug;73:304-311
International immunopharmacology 2019 Aug;73:304-311
(-)-Epicatechin mitigates radiation-induced intestinal injury and promotes intestinal regeneration via suppressing oxidative stress.
Li Y, Ma S, Zhang Y, Yao M, Zhu X, Guan F
Free radical research 2019 Aug;53(8):851-864
Free radical research 2019 Aug;53(8):851-864
Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.
Betharia S, Rondόn-Ortiz AN, Brown DA
Neurochemical research 2019 Aug;44(8):1878-1892
Neurochemical research 2019 Aug;44(8):1878-1892
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J
Pharmacological research 2019 Aug;146:104276
Pharmacological research 2019 Aug;146:104276
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Wang Z, Liang M, Li H, Cai L, He H, Wu Q, Yang L
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Wang Y, Yang C, Elsheikh NAH, Li C, Yang F, Wang G, Li L
Aging 2019 Aug 12;11(15):5535-5547
Aging 2019 Aug 12;11(15):5535-5547
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241
Food & function 2019 Aug 1;10(8):5240-5241
KLF15 regulates endobiotic and xenobiotic metabolism.
Han S, Ray JW, Pathak P, Sweet DR, Zhang R, Gao H, Jain N, Koritzinsky EH, Matoba K, Xu W, Chan ER, Simon DI, Jain MK
Nature metabolism 2019 Apr;1(4):422-430
Nature metabolism 2019 Apr;1(4):422-430
Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner.
Zhang B, Wang G, He J, Yang Q, Li D, Li J, Zhang F
Journal of neuroinflammation 2019 Apr 22;16(1):92
Journal of neuroinflammation 2019 Apr 22;16(1):92
Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1.
Zhang L, Chen Z, Gong W, Zou Y, Xu F, Chen L, Huang H
Frontiers in pharmacology 2018;9:512
Frontiers in pharmacology 2018;9:512
A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis.
Ren Z, Li H, Zhang M, Zhao Y, Fang X, Li X, Chen W, Zhang H, Wang Y, Pan LL, Sun J
Frontiers in immunology 2018;9:2513
Frontiers in immunology 2018;9:2513
Fangchinoline Ameliorates the Expressions of Angiogenic Molecule in Cerebral Ischemia Induced Neuronal Degeneration in Neonatal Rats.
Daicheng H, Shiwen X, Huaping Z, Yong L, Qianqian Z, Changxia H
Translational neuroscience 2018;9:117-122
Translational neuroscience 2018;9:117-122
Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats.
Zhao F, Lei F, Yan X, Zhang S, Wang W, Zheng Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(5):1815-1828
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(5):1815-1828
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Li YR, Li GH, Sun L, Li L, Liu Y, Kong DG, Wang SQ, Ren DM, Wang XN, Lou HX, Shen T
Oxidative medicine and cellular longevity 2018;2018:7616852
Oxidative medicine and cellular longevity 2018;2018:7616852
Hepatoprotective Activity of the Ethanolic Extract of Polygonum multiflorum Thunb. against Oxidative Stress-Induced Liver Injury.
Lin EY, Chagnaadorj A, Huang SJ, Wang CC, Chiang YH, Cheng CW
Evidence-based complementary and alternative medicine : eCAM 2018;2018:4130307
Evidence-based complementary and alternative medicine : eCAM 2018;2018:4130307
Nrf2 protects stellate cells from Smad-dependent cell activation.
Prestigiacomo V, Suter-Dick L
PloS one 2018;13(7):e0201044
PloS one 2018;13(7):e0201044
Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia.
Belcher JD, Gomperts E, Nguyen J, Chen C, Abdulla F, Kiser ZM, Gallo D, Levy H, Otterbein LE, Vercellotti GM
PloS one 2018;13(10):e0205194
PloS one 2018;13(10):e0205194
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
Li X, Cui XX, Chen YJ, Wu TT, Xu H, Yin H, Wu YC
Frontiers in aging neuroscience 2018;10:121
Frontiers in aging neuroscience 2018;10:121
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, Li X, Xie C, Zhong C, Fu S
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Local low dose curcumin treatment improves functional recovery and remyelination in a rat model of sciatic nerve crush through inhibition of oxidative stress.
Caillaud M, Chantemargue B, Richard L, Vignaud L, Favreau F, Faye PA, Vignoles P, Sturtz F, Trouillas P, Vallat JM, Desmoulière A, Billet F
Neuropharmacology 2018 Sep 1;139:98-116
Neuropharmacology 2018 Sep 1;139:98-116
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Enhanced anti-obesity effects of bacterial cellulose combined with konjac glucomannan in high-fat diet-fed C57BL/6J mice.
Zhai X, Lin D, Zhao Y, Li W, Yang X
Food & function 2018 Oct 17;9(10):5260-5272
Food & function 2018 Oct 17;9(10):5260-5272
Renoprotective Effects of Antroquinonol in Rats with N(ω)-Nitro-l-Arginine Methyl Ester-Induced Hypertension.
Chen JR, Ko J, Yeh WJ, Huang WC, Yang HY
Nutrients 2018 Oct 17;10(10)
Nutrients 2018 Oct 17;10(10)
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice.
Rong Y, Cao B, Liu B, Li W, Chen Y, Chen H, Liu Y, Liu T
International immunopharmacology 2018 Nov;64:183-191
International immunopharmacology 2018 Nov;64:183-191
Anti-neovascularization effects of DMBT in age-related macular degeneration by inhibition of VEGF secretion through ROS-dependent signaling pathway.
Chen S, Zhou Y, Zhou L, Guan Y, Zhang Y, Han X
Molecular and cellular biochemistry 2018 Nov;448(1-2):225-235
Molecular and cellular biochemistry 2018 Nov;448(1-2):225-235
Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks.
Khaliq H, Jing W, Ke X, Ke-Li Y, Peng-Peng S, Cui L, Wei-Wei Q, Zhixin L, Hua-Zhen L, Hui S, Ju-Ming Z, Ke-Mei P
Biological trace element research 2018 Nov;186(1):226-237
Biological trace element research 2018 Nov;186(1):226-237
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Zhang X, Li X, Fang J, Hou X, Fang H, Guo F, Li F, Chen A, Huang S
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
Zhang LM, Zhang J, Zhang Y, Wang L, Fei C, Yi ZW, Dong L
Biochemical and biophysical research communications 2018 Nov 2;505(3):837-842
Biochemical and biophysical research communications 2018 Nov 2;505(3):837-842
Exposure to formaldehyde and diisononyl phthalate exacerbate neuroinflammation through NF-κB activation in a mouse asthma model.
Duan J, Kang J, Qin W, Deng T, Liu H, Li B, Yu W, Gong S, Yang X, Chen M
Ecotoxicology and environmental safety 2018 Nov 15;163:356-364
Ecotoxicology and environmental safety 2018 Nov 15;163:356-364
Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model.
Wu C, Yang L, Tucker D, Dong Y, Zhu L, Duan R, Liu TC, Zhang Q
Medicine and science in sports and exercise 2018 May;50(5):945-956
Medicine and science in sports and exercise 2018 May;50(5):945-956
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
Li D, Wang X, Huang Q, Li S, Zhou Y, Li Z
Redox biology 2018 May;15:62-73
Redox biology 2018 May;15:62-73
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Li H, Tang Z, Chu P, Song Y, Yang Y, Sun B, Niu M, Qaed E, Shopit A, Han G, Ma X, Peng J, Hu M, Tang Z
Free radical biology & medicine 2018 May 20;120:228-238
Free radical biology & medicine 2018 May 20;120:228-238
Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis.
Akiyama K, Warabi E, Okada K, Yanagawa T, Ishii T, Kose K, Tokushige K, Ishige K, Mizokami Y, Yamagata K, Onizawa K, Ariizumi SI, Yamamoto M, Shoda J
Experimental animals 2018 May 10;67(2):201-218
Experimental animals 2018 May 10;67(2):201-218
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis.
Meng N, Tang H, Zhang H, Jiang C, Su L, Min X, Zhang W, Zhang H, Miao Z, Zhang W, Zhuang C
Free radical biology & medicine 2018 Mar;117:228-237
Free radical biology & medicine 2018 Mar;117:228-237
Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge.
Paraiso HC, Kuo PC, Curfman ET, Moon HJ, Sweazey RD, Yen JH, Chang FL, Yu IC
Journal of neuroinflammation 2018 Mar 29;15(1):100
Journal of neuroinflammation 2018 Mar 29;15(1):100
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Tang X, Liu B, Wang X, Yu Q, Fang R
International journal of molecular sciences 2018 Mar 14;19(3)
International journal of molecular sciences 2018 Mar 14;19(3)
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Zhang J, Tucker LD, DongYan, Lu Y, Yang L, Wu C, Li Y, Zhang Q
Neurochemistry international 2018 Jun;116:1-12
Neurochemistry international 2018 Jun;116:1-12
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
Evans JP, Winiarski BK, Sutton PA, Jones RP, Ressel L, Duckworth CA, Pritchard DM, Lin ZX, Fretwell VL, Tweedle EM, Costello E, Goldring CE, Copple IM, Park BK, Palmer DH, Kitteringham NR
Oncotarget 2018 Jun 5;9(43):27104-27116
Oncotarget 2018 Jun 5;9(43):27104-27116
LncRNA MT1DP Aggravates Cadmium-Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR-365.
Gao M, Li C, Xu M, Liu Y, Cong M, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2018 Jul;5(7):1800087
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2018 Jul;5(7):1800087
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
Xue S, He W, Zeng X, Tang Z, Feng S, Zhong Z, Xiong Y, Wang Y, Ye Q
Molecular medicine reports 2018 Jul;18(1):815-826
Molecular medicine reports 2018 Jul;18(1):815-826
Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.
Gao W, Xiao C, Hu J, Chen B, Wang C, Cui B, Deng P, Yang J, Deng Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:637-644
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:637-644
β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice.
Xu X, Ding Y, Yang Y, Gao Y, Sun Q, Liu J, Yang X, Wang J, Zhang J
Nutrients 2018 Jul 3;10(7)
Nutrients 2018 Jul 3;10(7)
Activation of Nrf2 might reduce oxidative stress in human granulosa cells.
Akino N, Wada-Hiraike O, Terao H, Honjoh H, Isono W, Fu H, Hirano M, Miyamoto Y, Tanikawa M, Harada M, Hirata T, Hirota Y, Koga K, Oda K, Kawana K, Fujii T, Osuga Y
Molecular and cellular endocrinology 2018 Jul 15;470:96-104
Molecular and cellular endocrinology 2018 Jul 15;470:96-104
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Dai C, Ciccotosto GD, Cappai R, Tang S, Li D, Xie S, Xiao X, Velkov T
Molecular neurobiology 2018 Jan;55(1):421-434
Molecular neurobiology 2018 Jan;55(1):421-434
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
Shi A, Shi H, Wang Y, Liu X, Cheng Y, Li H, Zhao H, Wang S, Dong L
International immunopharmacology 2018 Jan;54:125-130
International immunopharmacology 2018 Jan;54:125-130
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Lin EY, Bayarsengee U, Wang CC, Chiang YH, Cheng CW
Environmental toxicology 2018 Jan;33(1):72-82
Environmental toxicology 2018 Jan;33(1):72-82
A small molecule targeting glutathione activates Nrf2 and inhibits cancer cell growth through promoting Keap-1 S-glutathionylation and inducing apoptosis.
Wang L, Qu G, Gao Y, Su L, Ye Q, Jiang F, Zhao B, Miao J
RSC advances 2018 Jan 2;8(2):792-804
RSC advances 2018 Jan 2;8(2):792-804
Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-β1/Smad3 Pathway.
Peng X, Dai C, Liu Q, Li J, Qiu J
Molecules (Basel, Switzerland) 2018 Jan 19;23(1)
Molecules (Basel, Switzerland) 2018 Jan 19;23(1)
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
Liu M, Xu H, Zhang L, Zhang C, Yang L, Ma E, Liu L, Li Y
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus.
Wible RS, Ramanathan C, Sutter CH, Olesen KM, Kensler TW, Liu AC, Sutter TR
eLife 2018 Feb 26;7
eLife 2018 Feb 26;7
Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea.
Li L, Ren F, Qi C, Xu L, Fang Y, Liang M, Feng J, Chen B, Ning W, Cao J
Respiratory research 2018 Feb 12;19(1):28
Respiratory research 2018 Feb 12;19(1):28
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Li Y, Fu S, Li E, Sun X, Xu H, Meng Y, Wang X, Chen Y, Xie C, Geng S, Wu J, Zhong C, Xu P
Phytotherapy research : PTR 2018 Dec;32(12):2480-2486
Phytotherapy research : PTR 2018 Dec;32(12):2480-2486
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
Yang WJ, Li YR, Gao H, Wu XY, Wang XL, Wang XN, Xiang L, Ren DM, Lou HX, Shen T
Journal of ethnopharmacology 2018 Dec 5;227:166-175
Journal of ethnopharmacology 2018 Dec 5;227:166-175
NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer.
Zhang TT, Qu N, Sun GH, Zhang L, Wang YJ, Mu XM, Wei WJ, Wang YL, Wang Y, Ji QH, Zhu YX, Shi RL
International journal of oncology 2018 Aug;53(2):685-693
International journal of oncology 2018 Aug;53(2):685-693
Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications.
Wang Z, Yuan S, Li Y, Zhang Z, Xiao W, Tang D, Ye K, Liu Z, Wang C, Zheng Y, Nie H, Chen H
Biochemical pharmacology 2018 Apr;150:54-63
Biochemical pharmacology 2018 Apr;150:54-63
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
Zhang X, Wang Y, Velkov T, Tang S, Dai C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Apr;114:88-97
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Apr;114:88-97
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.
Dai C, Ciccotosto GD, Cappai R, Wang Y, Tang S, Hoyer D, Schneider EK, Velkov T, Xiao X
ACS chemical neuroscience 2018 Apr 18;9(4):824-837
ACS chemical neuroscience 2018 Apr 18;9(4):824-837
Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia.
Feng L, Li J, Yang L, Zhu L, Huang X, Zhang S, Luo L, Jiang Z, Jiang T, Xu W, Wang X, Jin H
Theranostics 2017;7(7):1890-1900
Theranostics 2017;7(7):1890-1900
Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways.
Du L, Lei Y, Chen J, Song H, Wu X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1359-1368
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1359-1368
Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1.
Liao HH, Zhu JX, Feng H, Ni J, Zhang N, Chen S, Liu HJ, Yang Z, Deng W, Tang QZ
Oxidative medicine and cellular longevity 2017;2017:8370593
Oxidative medicine and cellular longevity 2017;2017:8370593
TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity.
Wang Y, Gu YH, Liu M, Bai Y, Liang LY, Wang HL
Oxidative medicine and cellular longevity 2017;2017:4310475
Oxidative medicine and cellular longevity 2017;2017:4310475
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
Wang Y, Zhao W, Li G, Chen J, Guan X, Chen X, Guan Z
PPAR research 2017;2017:4089214
PPAR research 2017;2017:4089214
The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms.
Li L, Kong L, Song H
Experimental and therapeutic medicine 2017 Sep;14(3):2505-2510
Experimental and therapeutic medicine 2017 Sep;14(3):2505-2510
Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway.
Duan L, Li J, Ma P, Yang X, Xu S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):47-56
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):47-56
The effect of hydrogen sulfide-releasing naproxen (ATB-346) versus naproxen on formation of stress-induced gastric lesions, the regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation.
Magierowski M, Magierowska K, Surmiak M, Hubalewska-Mazgaj M, Kwiecien S, Wallace JL, Brzozowski T
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2017 Oct;68(5):749-756
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2017 Oct;68(5):749-756
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Liu J, Wang L, Du Y, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Carbon monoxide released from its pharmacological donor, tricarbonyldichlororuthenium (II) dimer, accelerates the healing of pre-existing gastric ulcers.
Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Sliwowski Z, Ginter G, Pajdo R, Chmura A, Kwiecien S, Brzozowski T
British journal of pharmacology 2017 Oct;174(20):3654-3668
British journal of pharmacology 2017 Oct;174(20):3654-3668
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H(2)S system: Role of oxidative stress and endoplasmic reticulum stress.
Liu S, Xin D, Wang L, Zhang T, Bai X, Li T, Xie Y, Xue H, Bo S, Liu D, Wang Z
Redox biology 2017 Oct;13:528-540
Redox biology 2017 Oct;13:528-540
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
Li D, Dai C, Yang X, Wang F, Yu X, Xiao X, Tang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
Fibroblast growth factor-2-mediated protection of cardiomyocytes from the toxic effects of doxorubicin requires the mTOR/Nrf-2/HO-1 pathway.
Koleini N, Nickel BE, Wang J, Roveimiab Z, Fandrich RR, Kirshenbaum LA, Cattini PA, Kardami E
Oncotarget 2017 Oct 20;8(50):87415-87430
Oncotarget 2017 Oct 20;8(50):87415-87430
An inducible form of Nrf2 confers enhanced protection against acute oxidative stresses in RPE cells.
Vu KT, Hulleman JD
Experimental eye research 2017 Nov;164:31-36
Experimental eye research 2017 Nov;164:31-36
SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis.
Huang R, Li X, Yu Y, Ma L, Liu S, Zong X, Zheng Q
Oncotarget 2017 Nov 7;8(55):94080-94090
Oncotarget 2017 Nov 7;8(55):94080-94090
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
Ge W, Zhao K, Wang X, Li H, Yu M, He M, Xue X, Zhu Y, Zhang C, Cheng Y, Jiang S, Hu Y
Cancer cell 2017 Nov 13;32(5):561-573.e6
Cancer cell 2017 Nov 13;32(5):561-573.e6
3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway.
Kuo PC, Yu IC, Scofield BA, Brown DA, Curfman ET, Paraiso HC, Chang FL, Yen JH
Brain, behavior, and immunity 2017 May;62:180-192
Brain, behavior, and immunity 2017 May;62:180-192
Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats.
Bai Y, Wang Y, Liu M, Gu YH, Jiang B, Wu X, Wang HL
Molecular medicine reports 2017 May;15(5):3135-3142
Molecular medicine reports 2017 May;15(5):3135-3142
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Dai C, Lei L, Li B, Lin Y, Xiao X, Tang S
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.
Gao M, Zhao B, Chen M, Liu Y, Xu M, Wang Z, Liu S, Zhang C
Biomaterials 2017 Jun;130:14-27
Biomaterials 2017 Jun;130:14-27
Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo.
Zhao X, Dong W, Gao Y, Shin DS, Ye Q, Su L, Jiang F, Zhao B, Miao J
Scientific reports 2017 Jun 20;7(1):3919
Scientific reports 2017 Jun 20;7(1):3919
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
Shen S, Li J, You H, Wu Z, Wu Y, Zhao Y, Zhu Y, Guo Q, Li X, Li R, Ma P, Yang X, Chen M
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jan;99:60-69
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jan;99:60-69
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Hu YR, Ma H, Zou ZY, He K, Xiao YB, Wang Y, Feng M, Ye XL, Li XG
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:313-322
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:313-322
Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells.
Zhang J, Su L, Ye Q, Zhang S, Kung H, Jiang F, Jiang G, Miao J, Zhao B
Oncotarget 2017 Jan 31;8(5):7625-7636
Oncotarget 2017 Jan 31;8(5):7625-7636
Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.
Wang Y, Gu YH, Liu M, Bai Y, Wang HL
Molecular medicine reports 2017 Feb;15(2):673-680
Molecular medicine reports 2017 Feb;15(2):673-680
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Basu M, Courtney SC, Brinton MA
PLoS pathogens 2017 Feb;13(2):e1006240
PLoS pathogens 2017 Feb;13(2):e1006240
Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD).
Kemter E, Fröhlich T, Arnold GJ, Wolf E, Wanke R
Scientific reports 2017 Feb 21;7:42970
Scientific reports 2017 Feb 21;7:42970
Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway.
Yang N, Shi JJ, Wu FP, Li M, Zhang X, Li YP, Zhai S, Jia XL, Dang SS
World journal of gastroenterology 2017 Feb 21;23(7):1203-1214
World journal of gastroenterology 2017 Feb 21;23(7):1203-1214
NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway.
Bernard K, Logsdon NJ, Miguel V, Benavides GA, Zhang J, Carter AB, Darley-Usmar VM, Thannickal VJ
The Journal of biological chemistry 2017 Feb 17;292(7):3029-3038
The Journal of biological chemistry 2017 Feb 17;292(7):3029-3038
Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.
Sang L, Wang XM, Xu DY, Sang LX, Han Y, Jiang LY
World journal of gastroenterology 2017 Dec 21;23(47):8334-8344
World journal of gastroenterology 2017 Dec 21;23(47):8334-8344
Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway.
Zhang J, Tong W, Sun H, Jiang M, Shen Y, Liu Y, Gu H, Guo J, Fang J, Jin L
Experimental gerontology 2017 Dec 15;100:77-86
Experimental gerontology 2017 Dec 15;100:77-86
(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.
Yang D, Xiao CX, Su ZH, Huang MW, Qin M, Wu WJ, Jia WW, Zhu YZ, Hu JF, Liu XH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Aug 15;32:15-23
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Aug 15;32:15-23
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.
Zhang C, Li C, Chen S, Li Z, Jia X, Wang K, Bao J, Liang Y, Wang X, Chen M, Li P, Su H, Wan JB, Lee SMY, Liu K, He C
Redox biology 2017 Apr;11:1-11
Redox biology 2017 Apr;11:1-11
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, Dong S, Yang F, Zhang L, Zhong X, Xu C, Lu F, Zhang W
Cell & bioscience 2016;6:33
Cell & bioscience 2016;6:33
Protective Effects of Hydrogen Sulfide in the Ageing Kidney.
Hou CL, Wang MJ, Sun C, Huang Y, Jin S, Mu XP, Chen Y, Zhu YC
Oxidative medicine and cellular longevity 2016;2016:7570489
Oxidative medicine and cellular longevity 2016;2016:7570489
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C
PloS one 2016;11(2):e0149032
PloS one 2016;11(2):e0149032
Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats.
Hu Q, Li T, Wang L, Xie Y, Liu S, Bai X, Zhang T, Bo S, Xin D, Xue H, Li G, Wang Z
Frontiers in cellular neuroscience 2016;10:306
Frontiers in cellular neuroscience 2016;10:306
Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice.
Han X, Li W, Huang D, Yang X
Chemico-biological interactions 2016 Sep 25;257:132-40
Chemico-biological interactions 2016 Sep 25;257:132-40
3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice.
Lu L, Dong J, Li D, Zhang J, Fan S
Free radical biology & medicine 2016 Oct;99:463-471
Free radical biology & medicine 2016 Oct;99:463-471
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:183-192
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:183-192
Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.
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The Journal of experimental medicine 2016 May 2;213(5):859-75
The Journal of experimental medicine 2016 May 2;213(5):859-75
Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway.
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Scientific reports 2016 Jun 13;6:27733
Scientific reports 2016 Jun 13;6:27733
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
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Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, Xu Y, Zhao Y, Wang C, Peng J
Nutrients 2016 Jul 8;8(7)
Nutrients 2016 Jul 8;8(7)
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Zhao L, Xu L, Tao X, Han X, Yin L, Qi Y, Peng J
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
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Toxicology research 2016 Jan 1;5(1):268-277
Toxicology research 2016 Jan 1;5(1):268-277
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2016 Feb;88:1-12
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2016 Feb;88:1-12
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Transplantation proceedings 2016 Dec;48(10):3378-3386
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Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.
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Renal failure 2016 Aug;38(7):1099-106
Renal failure 2016 Aug;38(7):1099-106
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Acta pharmacologica Sinica 2016 Aug;37(8):1063-75
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Taurine protects against As2O3-induced autophagy in pancreas of rat offsprings through Nrf2/Trx pathway.
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Biochimie 2016 Apr;123:1-6
Biochimie 2016 Apr;123:1-6
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Toxicology in vitro : an international journal published in association with BIBRA 2015 Mar;29(2):380-8
Toxicology in vitro : an international journal published in association with BIBRA 2015 Mar;29(2):380-8
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Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
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Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
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Chemical research in toxicology 2015 Apr 20;28(4):765-74
Chemical research in toxicology 2015 Apr 20;28(4):765-74
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Zhao F, Li K, Zhao L, Liu J, Suo Q, Zhao J, Wang H, Zhao S
International journal of clinical and experimental pathology 2014;7(6):2780-9
International journal of clinical and experimental pathology 2014;7(6):2780-9
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- DMSO treated HeLa cells were subjected to SDS PAGE followed by western blot with 16396-1-AP( NRF2, NFE2L2 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-NRF2, NFE2L2 (IP:16396-1-AP, 3ug; Detection:16396-1-AP 1:300) with mouse kidney tissue lysate 7000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NRF2, NFE2L2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NRF2, NFE2L2. This antibody recognizes human, mouse antigen. The NRF2, NFE2L2 antibody has been validated for the following applications: ELISA, IP, WB, IHC analysis.
