11089-1-AP

antibody from Proteintech Group

Targeting: NFE2 NF-E2

Provider product page for 11089-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [20]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 11089-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11089-1-AP, RRID:AB_2152928
Product name: NFE2 antibody
Antibody type: Polyclonal
Description: NFE2 antibody (Cat. #11089-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

NFE2 protein structure - 11089-1-AP shown in red.

Submitted references Naringenin inhibits Ferroptosis and ameliorates interstitial cystitis with metabolic syndrome by activating the Nrf2/NQO-1 pathway.

Zhao J, Ju C, Shao C, Sun Y, Yang T, Liu J, Wu D, Li H, Jia R, Zhou L, Zhao F
International immunopharmacology 2026 May 1;176:116485

Ginkgolic acid: a novel IL1R1 agonist facilitating megakaryocyte differentiation and platelet production via the SRC/MEK/ERK pathway.

Wang Y, Liao R, Liao R, Huang M, Jiang P, Liu Z, Wu A, Huang F, Huang Q, Luo J, Wang L, Wu J
International immunopharmacology 2026 Jan 1;168(Pt 2):115884

Regulating mitochondrial oxidative phosphorylation and MAPK signaling: wedelolactone as a novel therapeutic for radiation-induced thrombocytopenia.

Li Z, Li Q, Wu S, Mei X, Qi X, Liu S, Qiao G, Shen H, Luo J, Zeng J, Huang F, Li R, Wang L
Frontiers in pharmacology 2025;16:1508215

Ferulic acid promotes thrombopoiesis via TLR4/JAK2/STAT3 signaling: A novel therapeutic strategy for thrombocytopenia.

Liao R, Huang M, Liu Z, Wang X, Gan X, Hao L, Jiang P, Luo J, Huang Q, Mei Q, Wu A, Wang L, Wu J
Biochemical pharmacology 2025 Sep;239:117088

Oxymatrine, a novel TLR2 agonist, promotes megakaryopoiesis and thrombopoiesis through the STING/NF-κB pathway.

Ni C, Zhou L, Yang S, Ran M, Luo J, Cheng K, Huang F, Tang X, Xie X, Qin D, Mei Q, Wang L, Xiao J, Wu J
Journal of pharmaceutical analysis 2025 Jan;15(1):101054

NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression.

Xu W, Liu J, Liu Q, Xu J, Zhou L, Liang Z, Huang H, Huang B, Xiao GG, Guo J
Cell reports 2025 Feb 25;44(2):115226

Genistin: A Novel Estrogen Analogue Targeting ERβ to Alleviate Thrombocytopenia.

Tang X, Liao R, Zhou L, Yi T, Ran M, Luo J, Huang F, Wu A, Mei Q, Wang L, Huang X, Wu J
International journal of biological sciences 2024;20(6):2236-2260

Harmine promotes megakaryocyte differentiation and thrombopoiesis by activating the Rac1/Cdc42/JNK pathway through a potential target of 5-HTR2A.

Liu X, Lai J, Zhang X, Wu A, Zhou L, Li Y, Huang Q, Huang X, Li H, Lan C, Liu J, Huang F, Wu J
Phytotherapy research : PTR 2024 Nov;38(11):5134-5149

Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway.

Li Y, Lai J, Ran M, Yi T, Zhou L, Luo J, Liu X, Tang X, Huang M, Xie X, Li H, Yang Y, Zou W, Wu J
European journal of pharmacology 2024 May 15;971:176548

Decreasing circ_0014614 promotes the differentiation of bone marrow flineage cells into megakaryocytes in essential thrombocythemia via activiation of miR-138-5p/caspase3 axis.

Yu G, Chen X, Lu W, Li Y, Chen Y, Yin C, Zheng Z, Huang X, Xu D
Blood cells, molecules & diseases 2024 Jul;107:102855

Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia.

Zhou L, Ni C, Liao R, Tang X, Yi T, Ran M, Huang M, Liao R, Zhou X, Qin D, Wang L, Huang F, Xie X, Wan Y, Luo J, Wang Y, Wu J
eLife 2024 Apr 4;13

Xanthotoxin, a novel inducer of platelet formation, promotes thrombocytopoiesis via IL-1R1 and MEK/ERK signaling.

Lai J, Li Y, Ran M, Huang Q, Huang F, Zhu L, Wu Y, Zou W, Xie X, Tang Y, Yang F, Wu A, Ge G, Wu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114811

Targeting CXCR1 alleviates hyperoxia-induced lung injury through promoting glutamine metabolism.

Qin H, Zhuang W, Liu X, Wu J, Li S, Wang Y, Liu X, Chen C, Zhang H
Cell reports 2023 Jul 25;42(7):112745

Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory activity on the transcription of CDH1 to promote the progression of prostate cancer.

Zhou J, Yan X, Liu Y, Yang J
Biochemical and biophysical research communications 2023 Apr 2;650:9-16

Paired guide RNA CRISPR-Cas9 screening for protein-coding genes and lncRNAs involved in transdifferentiation of human B-cells to macrophages.

Arnan C, Ullrich S, Pulido-Quetglas C, Nurtdinov R, Esteban A, Blanco-Fernandez J, Aparicio-Prat E, Johnson R, Pérez-Lluch S, Guigó R
BMC genomics 2022 May 26;23(1):402

Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation.

Lu Z, Huang L, Li Y, Xu Y, Zhang R, Zhou Q, Sun Q, Lu Y, Chen J, Shen Y, Li J, Zhao B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jan;9(2):e2102669

Targeting TLR2/Rac1/cdc42/JNK Pathway to Reveal That Ruxolitinib Promotes Thrombocytopoiesis.

Yang S, Tang X, Wang L, Ni C, Wu Y, Zhou L, Zeng Y, Zhao C, Wu A, Wang Q, Xu X, Wang Y, Chen R, Zhang X, Zou L, Huang X, Wu J
International journal of molecular sciences 2022 Dec 17;23(24)

ERK and p38 MAPK inhibition controls NF-E2 degradation and profibrotic signaling in renal proximal tubule cells.

Li J, Jin S, Barati MT, Rane S, Lin Q, Tan Y, Cai L, Rane MJ
Life sciences 2021 Dec 15;287:120092

Loss of NF-E2 expression contributes to the induction of profibrotic signaling in diabetic kidneys.

Jin S, Li J, Barati M, Rane S, Lin Q, Tan Y, Zheng Z, Cai L, Rane MJ
Life sciences 2020 Aug 1;254:117783

Heme levels are increased in human failing hearts.

Khechaduri A, Bayeva M, Chang HC, Ardehali H
Journal of the American College of Cardiology 2013 May 7;61(18):1884-93

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: K-562 cells were subjected to SDS PAGE followed by western blot with 11089-1-AP(NFE2 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using NFE2 antibody 11089-1-AP at 1:100 dilution and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 11089-1-AP(NFE2 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue