10344-1-AP

antibody from Proteintech Group

Targeting: UBE3A ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

10344-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10344-1-AP, RRID:AB_2211801

Product name

UBE3A antibody

Antibody type

Polyclonal

Description

UBE3A antibody (Cat. #10344-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

UBQLN1 Inhibition reduces MASH progression through downregulating SIKE/p38 MAPK pathway in hepatocyte.

Chen Y, Yang F, Zheng G, Wang Y, Liu L, Yan Y
Journal of nanobiotechnology 2026 Mar 11;24(1)

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Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies.

Serdiuk T, Redeker V, Savistchenko J, Neupane S, Haenseler W, Fleischmann Y, Reber V, Keller S, Tiberi C, Bachmann-Gagescu R, Gstaiger M, Braun T, Riek R, Gentleman S, Aguzzi A, de Souza N, Melki R, Picotti P
Molecular systems biology 2026 Mar 11;

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Multi-targeting zinc finger nuclease vector unsilences paternal UBE3A in a mouse model of Angelman syndrome.

Bazick HO, James LM, Taylor-Blake B, Wolter JM, Zylka MJ
Gene therapy 2026 Jan;33(1):57-67

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Single-nucleus multi-omics identifies shared and distinct pathways in Pick's and Alzheimer's disease.

Shi Z, Das S, Morabito S, Stocksdale J, Miyoshi E, Srinivasan SS, Emerson N, Shahin A, Rahimzadeh N, Cao Z, Silva J, Castaneda AA, Head E, Thompson L, Swarup V
Science advances 2025 Nov 14;11(46):eads7973

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CRIP1 exacerbates osteoarthritis progression by recruiting UBE3A to induce the ubiquitination-mediated degradation of MFGE8.

Li Y, Cheng C, Li M, Hou Y, Li J, Duan S, Gao E, Liu K, Dai Z
Biochemical pharmacology 2025 Dec;242(Pt 4):117407

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UBQLN2 is necessary for UBE3A-mediated proteasomal degradation of the domesticated retroelement PEG10.

Roberts JE, Huynh PT, Carale LO, Whiteley AM
Journal of cell science 2025 Dec 15;138(24)

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UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation.

Loix M, Vanherle S, Bolkaerts L, Verberk SGS, Punt M, Wouters F, Moonen B, Verhagen R, Van Wouw SAE, Jongejan A, Distel B, Elgersma Y, Haidar M, Zelcer N, Hendriks JJA, Bogie JFJ
Nature communications 2025 Aug 29;16(1):8077

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Single-nucleus multi-omics identifies shared and distinct pathways in Pick's and Alzheimer's disease.

Shi Z, Das S, Morabito S, Miyoshi E, Stocksdale J, Emerson N, Srinivasan SS, Shahin A, Rahimzadeh N, Cao Z, Silva J, Castaneda AA, Head E, Thompson L, Swarup V
bioRxiv : the preprint server for biology 2024 Sep 8;

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UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells.

Luo Y, Yang Y, Yang C, Li C, Hu R, Geng W, Kang X, Lin H
FEBS open bio 2023 Sep;13(9):1756-1771

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SNORD6 promotes cervical cancer progression by accelerating E6-mediated p53 degradation.

Li Q, Xie B, Chen X, Lu B, Chen S, Sheng X, Zhao Y
Cell death discovery 2023 Jun 27;9(1):192

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FRMD3 inhibits the growth and metastasis of breast cancer through the ubiquitination-mediated degradation of vimentin and subsequent impairment of focal adhesion.

Shao W, Li J, Piao Q, Yao X, Li M, Wang S, Song Z, Sun Y, Zheng L, Wang G, Liu L, Yu C, Huang Y, Bao Y, Sun L
Cell death & disease 2023 Jan 11;14(1):13

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E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure.

Buel GR, Chen X, Myint W, Kayode O, Folimonova V, Cruz A, Skorupka KA, Matsuo H, Walters KJ
Structure (London, England : 1993) 2023 Apr 6;31(4):395-410.e6

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Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors.

Tan Q, Liu Z, Gao X, Wang Y, Qiu X, Chen J, Liang L, Guo H, Huang S, Wu D, Zhou B, Hu R, Li Z
Oncogene 2022 Oct;41(42):4754-4767

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The RBPJ/DAPK3/UBE3A signaling axis induces PBRM1 degradation to modulate the sensitivity of renal cell carcinoma to CDK4/6 inhibitors.

Liu W, Zhang B, Zhang D, Guo F, Ye K, Zhu L, Jin X
Cell death & disease 2022 Apr 2;13(4):295

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UBE3A activates the NOTCH pathway and promotes esophageal cancer progression by degradation of ZNF185.

Zheng Z, Zhang B, Yu H, Li S, Song N, Jin X, Li J
International journal of biological sciences 2021;17(12):3024-3035

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The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells.

Wang Y, Xie Y, Sun B, Guo Y, Song L, Mohammednur DE, Zhao C
Infectious agents and cancer 2021 Dec 24;16(1):71

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Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA.

Wolter JM, Mao H, Fragola G, Simon JM, Krantz JL, Bazick HO, Oztemiz B, Stein JL, Zylka MJ
Nature 2020 Nov;587(7833):281-284

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Landscape of genomic imprinting and its functions in the mouse mammary gland.

Xu H, Zhao L, Feng X, Ma Y, Chen W, Zou L, Yang Q, Sun J, Yu H, Jiao B
Journal of molecular cell biology 2020 May 5;12(11):857-869

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N-myc downstream-regulated gene 2 promotes the protein stability of estrogen receptor beta via inhibition of ubiquitin-protein ligase E3A to suppress colorectal cancer.

Zhu J, Lv Y, Hao J, Shi T, Wang S, Wang K, Fan X, Guo Y, Zhang J, Li J
Journal of gastrointestinal oncology 2020 Dec;11(6):1200-1213

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All-Trans Retinoic Acid Exerts Neuroprotective Effects in Amyotrophic Lateral Sclerosis-Like Tg (SOD1*G93A)1Gur Mice.

Zhu Y, Liu Y, Yang F, Chen W, Jiang J, He P, Jiang S, Li M, Xu R
Molecular neurobiology 2020 Aug;57(8):3603-3615

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Taurine Administration Recovers Motor and Learning Deficits in an Angelman Syndrome Mouse Model.

Guzzetti S, Calzari L, Buccarello L, Cesari V, Toschi I, Cattaldo S, Mauro A, Pregnolato F, Mazzola SM, Russo S
International journal of molecular sciences 2018 Apr 5;19(4)

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse brain tissue were subjected to SDS PAGE followed by western blot with 10344-1-AP(UBE3A antibody) at dilution of 1:1000

Sample type

tissue

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of Hela cells, using UBE3A antibody 10344-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human kidney using 10344-1-AP(UBE3A antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human kidney using 10344-1-AP(UBE3A antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue