10344-1-AP
antibody from Proteintech Group
Targeting: UBE3A
ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A
Antibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 10344-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10344-1-AP, RRID:AB_2211801
- Product name
- UBE3A antibody
- Antibody type
- Polyclonal
- Description
- UBE3A antibody (Cat. #10344-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells.
SNORD6 promotes cervical cancer progression by accelerating E6-mediated p53 degradation.
FRMD3 inhibits the growth and metastasis of breast cancer through the ubiquitination-mediated degradation of vimentin and subsequent impairment of focal adhesion.
E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure.
Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors.
The RBPJ/DAPK3/UBE3A signaling axis induces PBRM1 degradation to modulate the sensitivity of renal cell carcinoma to CDK4/6 inhibitors.
UBE3A activates the NOTCH pathway and promotes esophageal cancer progression by degradation of ZNF185.
The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells.
Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA.
Landscape of genomic imprinting and its functions in the mouse mammary gland.
N-myc downstream-regulated gene 2 promotes the protein stability of estrogen receptor beta via inhibition of ubiquitin-protein ligase E3A to suppress colorectal cancer.
All-Trans Retinoic Acid Exerts Neuroprotective Effects in Amyotrophic Lateral Sclerosis-Like Tg (SOD1*G93A)1Gur Mice.
Taurine Administration Recovers Motor and Learning Deficits in an Angelman Syndrome Mouse Model.
Luo Y, Yang Y, Yang C, Li C, Hu R, Geng W, Kang X, Lin H
FEBS open bio 2023 Sep;13(9):1756-1771
FEBS open bio 2023 Sep;13(9):1756-1771
SNORD6 promotes cervical cancer progression by accelerating E6-mediated p53 degradation.
Li Q, Xie B, Chen X, Lu B, Chen S, Sheng X, Zhao Y
Cell death discovery 2023 Jun 27;9(1):192
Cell death discovery 2023 Jun 27;9(1):192
FRMD3 inhibits the growth and metastasis of breast cancer through the ubiquitination-mediated degradation of vimentin and subsequent impairment of focal adhesion.
Shao W, Li J, Piao Q, Yao X, Li M, Wang S, Song Z, Sun Y, Zheng L, Wang G, Liu L, Yu C, Huang Y, Bao Y, Sun L
Cell death & disease 2023 Jan 11;14(1):13
Cell death & disease 2023 Jan 11;14(1):13
E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure.
Buel GR, Chen X, Myint W, Kayode O, Folimonova V, Cruz A, Skorupka KA, Matsuo H, Walters KJ
Structure (London, England : 1993) 2023 Apr 6;31(4):395-410.e6
Structure (London, England : 1993) 2023 Apr 6;31(4):395-410.e6
Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors.
Tan Q, Liu Z, Gao X, Wang Y, Qiu X, Chen J, Liang L, Guo H, Huang S, Wu D, Zhou B, Hu R, Li Z
Oncogene 2022 Oct;41(42):4754-4767
Oncogene 2022 Oct;41(42):4754-4767
The RBPJ/DAPK3/UBE3A signaling axis induces PBRM1 degradation to modulate the sensitivity of renal cell carcinoma to CDK4/6 inhibitors.
Liu W, Zhang B, Zhang D, Guo F, Ye K, Zhu L, Jin X
Cell death & disease 2022 Apr 2;13(4):295
Cell death & disease 2022 Apr 2;13(4):295
UBE3A activates the NOTCH pathway and promotes esophageal cancer progression by degradation of ZNF185.
Zheng Z, Zhang B, Yu H, Li S, Song N, Jin X, Li J
International journal of biological sciences 2021;17(12):3024-3035
International journal of biological sciences 2021;17(12):3024-3035
The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells.
Wang Y, Xie Y, Sun B, Guo Y, Song L, Mohammednur DE, Zhao C
Infectious agents and cancer 2021 Dec 24;16(1):71
Infectious agents and cancer 2021 Dec 24;16(1):71
Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA.
Wolter JM, Mao H, Fragola G, Simon JM, Krantz JL, Bazick HO, Oztemiz B, Stein JL, Zylka MJ
Nature 2020 Nov;587(7833):281-284
Nature 2020 Nov;587(7833):281-284
Landscape of genomic imprinting and its functions in the mouse mammary gland.
Xu H, Zhao L, Feng X, Ma Y, Chen W, Zou L, Yang Q, Sun J, Yu H, Jiao B
Journal of molecular cell biology 2020 May 5;12(11):857-869
Journal of molecular cell biology 2020 May 5;12(11):857-869
N-myc downstream-regulated gene 2 promotes the protein stability of estrogen receptor beta via inhibition of ubiquitin-protein ligase E3A to suppress colorectal cancer.
Zhu J, Lv Y, Hao J, Shi T, Wang S, Wang K, Fan X, Guo Y, Zhang J, Li J
Journal of gastrointestinal oncology 2020 Dec;11(6):1200-1213
Journal of gastrointestinal oncology 2020 Dec;11(6):1200-1213
All-Trans Retinoic Acid Exerts Neuroprotective Effects in Amyotrophic Lateral Sclerosis-Like Tg (SOD1*G93A)1Gur Mice.
Zhu Y, Liu Y, Yang F, Chen W, Jiang J, He P, Jiang S, Li M, Xu R
Molecular neurobiology 2020 Aug;57(8):3603-3615
Molecular neurobiology 2020 Aug;57(8):3603-3615
Taurine Administration Recovers Motor and Learning Deficits in an Angelman Syndrome Mouse Model.
Guzzetti S, Calzari L, Buccarello L, Cesari V, Toschi I, Cattaldo S, Mauro A, Pregnolato F, Mazzola SM, Russo S
International journal of molecular sciences 2018 Apr 5;19(4)
International journal of molecular sciences 2018 Apr 5;19(4)
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10344-1-AP(UBE3A antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using UBE3A antibody 10344-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 10344-1-AP(UBE3A antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 10344-1-AP(UBE3A antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue