Antibody data
- Antibody Data
- Antigen structure
- References [40]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 14972-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14972-1-AP, RRID:AB_2265677
- Product name
- LEF1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LEF1 antibody (Cat. #14972-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sinensetin suppresses breast cancer cell progression via Wnt/β-catenin pathway inhibition.
Targeting the IRE1α-XBP1s axis confers selective vulnerability in hepatocellular carcinoma with activated Wnt signaling.
Pancreatic stellate cell-derived exosomal tRF-19-PNR8YPJZ promotes proliferation and mobility of pancreatic cancer through AXIN2.
Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
Exosomal miR-128-3p reversed fibrinogen-mediated inhibition of oligodendrocyte progenitor cell differentiation and remyelination after cerebral ischemia.
Ursolic Acid Suppresses Colorectal Cancer by Down-Regulation of Wnt/β-Catenin Signaling Pathway Activity.
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells.
Hordenine Activated Dermal Papilla Cells and Promoted Hair Regrowth by Activating Wnt Signaling Pathway.
Early growth response 2 in the mPFC regulates mouse social and cooperative behaviors.
TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal.
Effect of overexpression of KLF4 on the growth and development of hair follicles in mice.
Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity.
Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model.
SiNiSan alleviates liver injury by promoting hepatic stem cell differentiation via Wnt/β-catenin signaling pathway.
miR-145-5p targets MMP2 to protect brain injury in hypertensive intracerebral hemorrhage via inactivation of the Wnt/β-catenin signaling pathway.
CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/β-catenin signaling.
Exosomal miRNA-181a-5p from the cells of the hair follicle dermal papilla promotes the hair follicle growth and development via the Wnt/β-catenin signaling pathway.
Characterization and functional analysis of lncRNA2690 in regulating the growth cycle of the hair follicle in rabbits.
DNA Methylation Mediates lncRNA2919 Regulation of Hair Follicle Regeneration.
Comprehensive Analysis of the Potential Immune-Related Biomarker Transporter Associated With Antigen Processing 1 That Inhibits Metastasis and Invasion of Ovarian Cancer Cells.
FHL1 Inhibits the Progression of Colorectal Cancer by Regulating the Wnt/β-Catenin Signaling Pathway.
Screening and Identification of Key Biomarkers of Gastric Cancer: Three Genes Jointly Predict Gastric Cancer.
MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
The protective mechanism of SIRT1 on cartilage through regulation of LEF-1.
Long non-coding RNA AC122108.1 promotes lung adenocarcinoma brain metastasis and progression through the Wnt/β-catenin pathway by directly binding to aldolase A.
Potential molecular mechanism of cardiac hypertrophy in mice induced by exposure to ambient PM(2.5).
Phosphofructokinase-1 Inhibition Promotes Neuronal Differentiation of Neural Stem Cells and Functional Recovery After Stroke.
Ginsenoside Rg1 Improves Differentiation by Inhibiting Senescence of Human Bone Marrow Mesenchymal Stem Cell via GSK-3β and β-Catenin.
Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor.
Dedicator of cytokinesis protein 2 couples with lymphoid enhancer-binding factor 1 to regulate expression of CD21 and B-cell differentiation.
AKIP1 promotes early recurrence of hepatocellular carcinoma through activating the Wnt/β-catenin/CBP signaling pathway.
A novel long noncoding RNA AK016739 inhibits osteoblast differentiation and bone formation.
Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice.
Overexpression of MYC binding protein promotes invasion and migration in gastric cancer.
microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma.
Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway.
TIMELESS confers cisplatin resistance in nasopharyngeal carcinoma by activating the Wnt/β-catenin signaling pathway and promoting the epithelial mesenchymal transition.
Dimethyloxalylglycine prevents bone loss in ovariectomized C57BL/6J mice through enhanced angiogenesis and osteogenesis.
Inhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling.
Zhu S, Meng L, Wei P, Gu G, Duan K
Translational cancer research 2024 Jan 31;13(1):348-362
Translational cancer research 2024 Jan 31;13(1):348-362
Targeting the IRE1α-XBP1s axis confers selective vulnerability in hepatocellular carcinoma with activated Wnt signaling.
Zhang T, Zhao F, Zhang Y, Shi JH, Cui F, Ma W, Wang K, Xu C, Zeng Q, Zhong R, Li N, Liu Y, Jin Y, Sheng X
Oncogene 2024 Apr;43(17):1233-1248
Oncogene 2024 Apr;43(17):1233-1248
Pancreatic stellate cell-derived exosomal tRF-19-PNR8YPJZ promotes proliferation and mobility of pancreatic cancer through AXIN2.
Cao W, Dai S, Ruan W, Long T, Zeng Z, Lei S
Journal of cellular and molecular medicine 2023 Sep;27(17):2533-2546
Journal of cellular and molecular medicine 2023 Sep;27(17):2533-2546
Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
Liu T, Fan MQ, Xie XX, Shu QP, Du XH, Qi LZ, Zhang XD, Zhang MH, Shan G, Du RL, Li SZ
Journal of translational medicine 2023 Sep 22;21(1):656
Journal of translational medicine 2023 Sep 22;21(1):656
Exosomal miR-128-3p reversed fibrinogen-mediated inhibition of oligodendrocyte progenitor cell differentiation and remyelination after cerebral ischemia.
Hou H, Wang Y, Yang L, Wang Y
CNS neuroscience & therapeutics 2023 May;29(5):1405-1422
CNS neuroscience & therapeutics 2023 May;29(5):1405-1422
Ursolic Acid Suppresses Colorectal Cancer by Down-Regulation of Wnt/β-Catenin Signaling Pathway Activity.
Zhao H, Tang S, Tao Q, Ming T, Lei J, Liang Y, Peng Y, Wang M, Liu M, Yang H, Ren S, Xu H
Journal of agricultural and food chemistry 2023 Mar 8;71(9):3981-3993
Journal of agricultural and food chemistry 2023 Mar 8;71(9):3981-3993
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
Kurihara C, Sakurai R, Chuang TD, Waring AJ, Walther FJ, Rehan VK
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells.
Wang P, Huang L, Yang F, Chen W, Bai D, Guo Y
MedComm 2023 Jun;4(3):e246
MedComm 2023 Jun;4(3):e246
Hordenine Activated Dermal Papilla Cells and Promoted Hair Regrowth by Activating Wnt Signaling Pathway.
Wang C, Zang K, Tang Z, Yang T, Ye X, Dang Y
Nutrients 2023 Jan 30;15(3)
Nutrients 2023 Jan 30;15(3)
Early growth response 2 in the mPFC regulates mouse social and cooperative behaviors.
Zhang Y, Feng W, Wang Z, Pang Y, Jin Y, Chen S, Ding S, Wang T, Zou Y, Sun P, Chen Y, Feng H, Huang H, Sheng C, Xiao M
Lab animal 2023 Feb;52(2):37-50
Lab animal 2023 Feb;52(2):37-50
TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal.
Wang J, Zhao D, Lei Z, Ge P, Lu Z, Chai Q, Zhang Y, Qiang L, Yu Y, Zhang X, Li B, Zhu S, Zhang L, Liu CH
Cellular & molecular immunology 2023 Feb;20(2):158-174
Cellular & molecular immunology 2023 Feb;20(2):158-174
Effect of overexpression of KLF4 on the growth and development of hair follicles in mice.
Han H, Qin H, Yang Y, Zhao L, Shen T, Pang Q
Development genes and evolution 2023 Dec;233(2):137-145
Development genes and evolution 2023 Dec;233(2):137-145
Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity.
He T, Wang S, Li S, Shen H, Hou L, Liu Y, Wei Y, Xie F, Zhang Z, Zhao Z, Mo C, Guo H, Huang Q, Zhang R, Shen D, Li B
iScience 2023 Apr 21;26(4):106289
iScience 2023 Apr 21;26(4):106289
Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model.
Yang X, Luo G, Fu L, Huang H, Wang L, Yin L, Zhang X, Wang T, Ma X, Feng T, Ye J
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3193572
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3193572
SiNiSan alleviates liver injury by promoting hepatic stem cell differentiation via Wnt/β-catenin signaling pathway.
Xu W, Du X, Li J, Zhang Z, Ma X, Luo D, Xiao M, Sun Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153969
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153969
miR-145-5p targets MMP2 to protect brain injury in hypertensive intracerebral hemorrhage via inactivation of the Wnt/β-catenin signaling pathway.
Xiao W, Jiang Z, Wan W, Pan W, Xu J
Annals of translational medicine 2022 May;10(10):571
Annals of translational medicine 2022 May;10(10):571
CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/β-catenin signaling.
Zhu L, Yang X, Feng J, Mao J, Zhang Q, He M, Mi Y, Mei Y, Jin G, Zhang H
Journal of translational medicine 2022 May 4;20(1):194
Journal of translational medicine 2022 May 4;20(1):194
Exosomal miRNA-181a-5p from the cells of the hair follicle dermal papilla promotes the hair follicle growth and development via the Wnt/β-catenin signaling pathway.
Zhao B, Li J, Zhang X, Dai Y, Yang N, Bao Z, Chen Y, Wu X
International journal of biological macromolecules 2022 May 15;207:110-120
International journal of biological macromolecules 2022 May 15;207:110-120
Characterization and functional analysis of lncRNA2690 in regulating the growth cycle of the hair follicle in rabbits.
Bao Z, Zhai P, Yao F, Ren Y, Zhao B, Chen Y, Wu X
Animal genetics 2022 Dec;53(6):841-848
Animal genetics 2022 Dec;53(6):841-848
DNA Methylation Mediates lncRNA2919 Regulation of Hair Follicle Regeneration.
Zhao B, Li J, Liu M, Yang N, Bao Z, Zhang X, Dai Y, Cai J, Chen Y, Wu X
International journal of molecular sciences 2022 Aug 22;23(16)
International journal of molecular sciences 2022 Aug 22;23(16)
Comprehensive Analysis of the Potential Immune-Related Biomarker Transporter Associated With Antigen Processing 1 That Inhibits Metastasis and Invasion of Ovarian Cancer Cells.
Li X, Zeng S, Ding Y, Nie Y, Yang M
Frontiers in molecular biosciences 2021;8:763958
Frontiers in molecular biosciences 2021;8:763958
FHL1 Inhibits the Progression of Colorectal Cancer by Regulating the Wnt/β-Catenin Signaling Pathway.
Liu Y, Wang C, Cheng P, Zhang S, Zhou W, Xu Y, Xu H, Ji G
Journal of Cancer 2021;12(17):5345-5354
Journal of Cancer 2021;12(17):5345-5354
Screening and Identification of Key Biomarkers of Gastric Cancer: Three Genes Jointly Predict Gastric Cancer.
Shan MJ, Meng LB, Guo P, Zhang YM, Kong D, Liu YB
Frontiers in oncology 2021;11:591893
Frontiers in oncology 2021;11:591893
MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
Hu L, Yin C, Chen D, Wu Z, Liang S, Zhang Y, Huang Z, Liu S, Xu X, Chen Z, Zhang Y, Qian A
Cell death and differentiation 2021 Jul;28(7):2160-2178
Cell death and differentiation 2021 Jul;28(7):2160-2178
The protective mechanism of SIRT1 on cartilage through regulation of LEF-1.
Hu X, Feng G, Meng Z, Ma L, Jin Q
BMC musculoskeletal disorders 2021 Jul 27;22(1):642
BMC musculoskeletal disorders 2021 Jul 27;22(1):642
Long non-coding RNA AC122108.1 promotes lung adenocarcinoma brain metastasis and progression through the Wnt/β-catenin pathway by directly binding to aldolase A.
Feng S, Liu H, Du P, Dong X, Pang Q, Guo H
Annals of translational medicine 2021 Dec;9(23):1729
Annals of translational medicine 2021 Dec;9(23):1729
Potential molecular mechanism of cardiac hypertrophy in mice induced by exposure to ambient PM(2.5).
Liu Q, Han B, Zhang Y, Jiang T, Ning J, Kang A, Huang X, Zhang H, Pang Y, Zhang B, Wang Q, Niu Y, Zhang R
Ecotoxicology and environmental safety 2021 Aug 19;224:112659
Ecotoxicology and environmental safety 2021 Aug 19;224:112659
Phosphofructokinase-1 Inhibition Promotes Neuronal Differentiation of Neural Stem Cells and Functional Recovery After Stroke.
Zhang F, Li Q, Liang H, Zhang Y
Neuroscience 2021 Apr 1;459:27-38
Neuroscience 2021 Apr 1;459:27-38
Ginsenoside Rg1 Improves Differentiation by Inhibiting Senescence of Human Bone Marrow Mesenchymal Stem Cell via GSK-3β and β-Catenin.
Wang Z, Jiang R, Wang L, Chen X, Xiang Y, Chen L, Xiao M, Ling L, Wang Y
Stem cells international 2020;2020:2365814
Stem cells international 2020;2020:2365814
Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor.
Drake KA, Chaney CP, Das A, Roy P, Kwartler CS, Rakheja D, Carroll TJ
Development (Cambridge, England) 2020 Jul 31;147(21)
Development (Cambridge, England) 2020 Jul 31;147(21)
Dedicator of cytokinesis protein 2 couples with lymphoid enhancer-binding factor 1 to regulate expression of CD21 and B-cell differentiation.
Jing Y, Kang D, Liu L, Huang H, Chen A, Yang L, Jiang P, Li N, Miller H, Liu Z, Zhu X, Yang J, Wang X, Sun J, Liu Z, Liu W, Zhou X, Liu C
The Journal of allergy and clinical immunology 2019 Nov;144(5):1377-1390.e4
The Journal of allergy and clinical immunology 2019 Nov;144(5):1377-1390.e4
AKIP1 promotes early recurrence of hepatocellular carcinoma through activating the Wnt/β-catenin/CBP signaling pathway.
Cui Y, Wu X, Lin C, Zhang X, Ye L, Ren L, Chen M, Yang M, Li Y, Li M, Li J, Guan J, Song L
Oncogene 2019 Jul;38(27):5516-5529
Oncogene 2019 Jul;38(27):5516-5529
A novel long noncoding RNA AK016739 inhibits osteoblast differentiation and bone formation.
Yin C, Tian Y, Yu Y, Wang H, Wu Z, Huang Z, Zhang Y, Li D, Yang C, Wang X, Li Y, Qian A
Journal of cellular physiology 2019 Jul;234(7):11524-11536
Journal of cellular physiology 2019 Jul;234(7):11524-11536
Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice.
Xing F, Yi WJ, Miao F, Su MY, Lei TC
International journal of molecular medicine 2018 Apr;41(4):2079-2085
International journal of molecular medicine 2018 Apr;41(4):2079-2085
Overexpression of MYC binding protein promotes invasion and migration in gastric cancer.
Gong L, Xia Y, Qian Z, Shi J, Luo J, Song G, Xu J, Ye Z
Oncology letters 2018 Apr;15(4):5243-5249
Oncology letters 2018 Apr;15(4):5243-5249
microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma.
He XY, Tan ZL, Mou Q, Liu FJ, Liu S, Yu CW, Zhu J, Lv LY, Zhang J, Wang S, Bao LM, Peng B, Zhao H, Zou L
Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 1;23(11):2905-2918
Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 1;23(11):2905-2918
Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway.
Chen S, Sun YY, Zhang ZX, Li YH, Xu ZM, Fu WN
Oncotarget 2017 Feb 28;8(9):14708-14718
Oncotarget 2017 Feb 28;8(9):14708-14718
TIMELESS confers cisplatin resistance in nasopharyngeal carcinoma by activating the Wnt/β-catenin signaling pathway and promoting the epithelial mesenchymal transition.
Liu SL, Lin HX, Lin CY, Sun XQ, Ye LP, Qiu F, Wen W, Hua X, Wu XQ, Li J, Song LB, Guo L
Cancer letters 2017 Aug 28;402:117-130
Cancer letters 2017 Aug 28;402:117-130
Dimethyloxalylglycine prevents bone loss in ovariectomized C57BL/6J mice through enhanced angiogenesis and osteogenesis.
Peng J, Lai ZG, Fang ZL, Xing S, Hui K, Hao C, Jin Q, Qi Z, Shen WJ, Dong QN, Bing ZH, Fu DL
PloS one 2014;9(11):e112744
PloS one 2014;9(11):e112744
Inhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling.
Gong Y, Xu CY, Wang JR, Hu XH, Hong D, Ji X, Shi W, Chen HX, Wang HB, Wu XM
Cell death & disease 2014 Nov 27;5(11):e1544
Cell death & disease 2014 Nov 27;5(11):e1544
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- COLO 320 cells were subjected to SDS PAGE followed by western blot with 14972-1-AP( LEF1 Antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LEF1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LEF1. This antibody recognizes human,mouse,rat antigen. The LEF1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 14972-1-AP(LEF1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue