Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 14972-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14972-1-AP, RRID:AB_2265677
- Product name
- LEF1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LEF1 antibody (Cat. #14972-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references FHL1 Inhibits the Progression of Colorectal Cancer by Regulating the Wnt/β-Catenin Signaling Pathway.
Screening and Identification of Key Biomarkers of Gastric Cancer: Three Genes Jointly Predict Gastric Cancer.
MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
The protective mechanism of SIRT1 on cartilage through regulation of LEF-1.
Potential molecular mechanism of cardiac hypertrophy in mice induced by exposure to ambient PM2.5.
Ginsenoside Rg1 Improves Differentiation by Inhibiting Senescence of Human Bone Marrow Mesenchymal Stem Cell via GSK-3β and β-Catenin.
Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor.
Dedicator of cytokinesis protein 2 couples with lymphoid enhancer-binding factor 1 to regulate expression of CD21 and B-cell differentiation.
AKIP1 promotes early recurrence of hepatocellular carcinoma through activating the Wnt/β-catenin/CBP signaling pathway.
A novel long noncoding RNA AK016739 inhibits osteoblast differentiation and bone formation.
Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice.
Overexpression of MYC binding protein promotes invasion and migration in gastric cancer.
microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma.
Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway.
TIMELESS confers cisplatin resistance in nasopharyngeal carcinoma by activating the Wnt/β-catenin signaling pathway and promoting the epithelial mesenchymal transition.
Dimethyloxalylglycine prevents bone loss in ovariectomized C57BL/6J mice through enhanced angiogenesis and osteogenesis.
Inhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling.
Liu Y, Wang C, Cheng P, Zhang S, Zhou W, Xu Y, Xu H, Ji G
Journal of Cancer 2021;12(17):5345-5354
Journal of Cancer 2021;12(17):5345-5354
Screening and Identification of Key Biomarkers of Gastric Cancer: Three Genes Jointly Predict Gastric Cancer.
Shan MJ, Meng LB, Guo P, Zhang YM, Kong D, Liu YB
Frontiers in oncology 2021;11:591893
Frontiers in oncology 2021;11:591893
MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
Hu L, Yin C, Chen D, Wu Z, Liang S, Zhang Y, Huang Z, Liu S, Xu X, Chen Z, Zhang Y, Qian A
Cell death and differentiation 2021 Jul;28(7):2160-2178
Cell death and differentiation 2021 Jul;28(7):2160-2178
The protective mechanism of SIRT1 on cartilage through regulation of LEF-1.
Hu X, Feng G, Meng Z, Ma L, Jin Q
BMC musculoskeletal disorders 2021 Jul 27;22(1):642
BMC musculoskeletal disorders 2021 Jul 27;22(1):642
Potential molecular mechanism of cardiac hypertrophy in mice induced by exposure to ambient PM2.5.
Liu Q, Han B, Zhang Y, Jiang T, Ning J, Kang A, Huang X, Zhang H, Pang Y, Zhang B, Wang Q, Niu Y, Zhang R
Ecotoxicology and environmental safety 2021 Aug 19;224:112659
Ecotoxicology and environmental safety 2021 Aug 19;224:112659
Ginsenoside Rg1 Improves Differentiation by Inhibiting Senescence of Human Bone Marrow Mesenchymal Stem Cell via GSK-3β and β-Catenin.
Wang Z, Jiang R, Wang L, Chen X, Xiang Y, Chen L, Xiao M, Ling L, Wang Y
Stem cells international 2020;2020:2365814
Stem cells international 2020;2020:2365814
Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor.
Drake KA, Chaney CP, Das A, Roy P, Kwartler CS, Rakheja D, Carroll TJ
Development (Cambridge, England) 2020 Jul 31;147(21)
Development (Cambridge, England) 2020 Jul 31;147(21)
Dedicator of cytokinesis protein 2 couples with lymphoid enhancer-binding factor 1 to regulate expression of CD21 and B-cell differentiation.
Jing Y, Kang D, Liu L, Huang H, Chen A, Yang L, Jiang P, Li N, Miller H, Liu Z, Zhu X, Yang J, Wang X, Sun J, Liu Z, Liu W, Zhou X, Liu C
The Journal of allergy and clinical immunology 2019 Nov;144(5):1377-1390.e4
The Journal of allergy and clinical immunology 2019 Nov;144(5):1377-1390.e4
AKIP1 promotes early recurrence of hepatocellular carcinoma through activating the Wnt/β-catenin/CBP signaling pathway.
Cui Y, Wu X, Lin C, Zhang X, Ye L, Ren L, Chen M, Yang M, Li Y, Li M, Li J, Guan J, Song L
Oncogene 2019 Jul;38(27):5516-5529
Oncogene 2019 Jul;38(27):5516-5529
A novel long noncoding RNA AK016739 inhibits osteoblast differentiation and bone formation.
Yin C, Tian Y, Yu Y, Wang H, Wu Z, Huang Z, Zhang Y, Li D, Yang C, Wang X, Li Y, Qian A
Journal of cellular physiology 2019 Jul;234(7):11524-11536
Journal of cellular physiology 2019 Jul;234(7):11524-11536
Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice.
Xing F, Yi WJ, Miao F, Su MY, Lei TC
International journal of molecular medicine 2018 Apr;41(4):2079-2085
International journal of molecular medicine 2018 Apr;41(4):2079-2085
Overexpression of MYC binding protein promotes invasion and migration in gastric cancer.
Gong L, Xia Y, Qian Z, Shi J, Luo J, Song G, Xu J, Ye Z
Oncology letters 2018 Apr;15(4):5243-5249
Oncology letters 2018 Apr;15(4):5243-5249
microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma.
He XY, Tan ZL, Mou Q, Liu FJ, Liu S, Yu CW, Zhu J, Lv LY, Zhang J, Wang S, Bao LM, Peng B, Zhao H, Zou L
Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 1;23(11):2905-2918
Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 1;23(11):2905-2918
Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway.
Chen S, Sun YY, Zhang ZX, Li YH, Xu ZM, Fu WN
Oncotarget 2017 Feb 28;8(9):14708-14718
Oncotarget 2017 Feb 28;8(9):14708-14718
TIMELESS confers cisplatin resistance in nasopharyngeal carcinoma by activating the Wnt/β-catenin signaling pathway and promoting the epithelial mesenchymal transition.
Liu SL, Lin HX, Lin CY, Sun XQ, Ye LP, Qiu F, Wen W, Hua X, Wu XQ, Li J, Song LB, Guo L
Cancer letters 2017 Aug 28;402:117-130
Cancer letters 2017 Aug 28;402:117-130
Dimethyloxalylglycine prevents bone loss in ovariectomized C57BL/6J mice through enhanced angiogenesis and osteogenesis.
Peng J, Lai ZG, Fang ZL, Xing S, Hui K, Hao C, Jin Q, Qi Z, Shen WJ, Dong QN, Bing ZH, Fu DL
PloS one 2014;9(11):e112744
PloS one 2014;9(11):e112744
Inhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling.
Gong Y, Xu CY, Wang JR, Hu XH, Hong D, Ji X, Shi W, Chen HX, Wang HB, Wu XM
Cell death & disease 2014 Nov 27;5:e1544
Cell death & disease 2014 Nov 27;5:e1544
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- COLO 320 cells were subjected to SDS PAGE followed by western blot with 14972-1-AP( LEF1 Antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LEF1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LEF1. This antibody recognizes human,mouse,rat antigen. The LEF1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 14972-1-AP(LEF1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue