HPA001758

antibody from Atlas Antibodies

Targeting: SOX9 CMD1, CMPD1, SRA1

Provider product page for HPA001758

Western blot

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [41]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: HPA001758 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA001758, RRID:AB_1080067
Product name: Anti-SOX9
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human SOX9, Gene description: SRY (sex determining region Y)-box 9, Alternative Gene Names: CMD1, CMPD1, SRA1, Validated applications: ICC, IHC, WB, Uniprot ID: P48436, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.1 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

SOX9 protein structure - HPA001758 shown in red.

Submitted references Early embryogenesis in CHDFIDD mouse model reveals facial clefts and altered cranial neurogenesis

Hampl M, Jandová N, Lusková D, Nováková M, Szotkowská T, Čada Š, Procházka J, Kohoutek J, Buchtová M
Disease Models & Mechanisms 2024;17(6)

Sox9 regulates alternative splicing and pancreatic beta cell function

Puri S, Maachi H, Nair G, Russ H, Chen R, Pulimeno P, Cutts Z, Ntranos V, Hebrok M
Nature Communications 2024;15(1)

The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling

Xie M, Kaiser M, Gershtein Y, Schnyder D, Deviatiiarov R, Gazizova G, Shagimardanova E, Zikmund T, Kerckhofs G, Ivashkin E, Batkovskyte D, Newton P, Andersson O, Fried K, Gusev O, Zeberg H, Kaiser J, Adameyko I, Chagin A
Nature Communications 2024;15(1)

Pathology and causes of death in captive meerkats ( Suricata suricatta )

Martí-García B, Priestnall S, Suárez-Bonnet A
Veterinary Quarterly 2023;43(1):1-9

Notch Signaling Regulates the Chondrogenic Potential of Both Articular Chondrocytes and Their Progenitors During Expansion

Kurenkova A, Li L, Usanova A, Feng X, Zhou B, Nedorubov A, Lychagin A, Chagin A
Stem Cells 2023;41(6):658-671

Resveratrol’s Impact on the Chondrogenic Reagents’ Effects in Cell Sheet Cultures of Wharton’s Jelly-Derived MSCs

Kurenkova A, Presniakova V, Mosina Z, Kibirskiy P, Romanova I, Tugaeva G, Kosheleva N, Vinogradov K, Kostjuk S, Kotova S, Rochev Y, Medvedeva E, Timashev P
Cells 2023;12(24):2845

Frequent PIK3CA mutation in normal endometrial gland drives spheroid formation and may be involved in stem cell propagation.

Sato S, Nakayama K, Kanno K, Sultana R, Ishikawa M, Ishibashi T, Yamashita H, Kyo S
Cancer science 2023 Jun;114(6):2335-2344

SATINN: an automated neural network-based classification of testicular sections allows for high-throughput histopathology of mouse mutants

Yang R, Stendahl A, Vigh-Conrad K, Held M, Lima A, Conrad D, Peng H
Bioinformatics 2022;38(23):5288-5298

The transplantation of particulated juvenile allograft cartilage and synovium for the repair of meniscal defect in a lapine model

Yan W, Maimaitimin M, Zhao F, Fan Y, Yang S, Li Y, Cao C, Shao Z, Liu Z, Hu X, Ao Y, Cheng J
Journal of Orthopaedic Translation 2022;33

Development of ribs and intercostal muscles in the chicken embryo

Khabyuk J, Pröls F, Draga M, Scaal M
Journal of Anatomy 2022;241(3):831-845

Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms

Walker C, Chang H, Henegar L, Kashyap T, Shacham S, Sommer J, Wick M, Levy J, Landesman Y
Frontiers in Oncology 2022;12

Guided Self-Assembly of ES-Derived Lung Progenitors into Biomimetic Tube Structures That Impact Cell Differentiation

Soleas J, Huang L, D’Arcangelo E, Nostro M, Waddell T, McGuigan A, Karoubi G
Bioengineering 2021;8(12):209

Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation

Campbell N, Rao A, Hunter M, Sznurkowska M, Briker L, Zhang M, Baron M, Heilmann S, Deforet M, Kenny C, Ferretti L, Huang T, Perlee S, Garg M, Nsengimana J, Saini M, Montal E, Tagore M, Newton-Bishop J, Middleton M, Corrie P, Adams D, Rabbie R, Aceto N, Levesque M, Cornell R, Yanai I, Xavier J, White R
Developmental Cell 2021;56(20):2808-2825.e10

Implantation of Various Cell-Free Matrixes Does Not Contribute to the Restoration of Hyaline Cartilage within Full-Thickness Focal Defects

Ibragimova S, Medvedeva E, Romanova I, Istranov L, Istranova E, Lychagin A, Nedorubov A, Timashev P, Telpukhov V, Chagin A
International Journal of Molecular Sciences 2021;23(1):292

Symmetry and fluctuation of cell movements in neural crest-derived facial mesenchyme

Danescu A, Rens E, Rehki J, Woo J, Akazawa T, Fu K, Edelstein-Keshet L, Richman J
Development 2021;148(9)

Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries

Le Rolle M, Massa F, Siggers P, Turchi L, Loubat A, Koo B, Clevers H, Greenfield A, Schedl A, Chaboissier M, Chassot A
Proceedings of the National Academy of Sciences 2021;118(30)

Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversals

Richardson N, Gillot I, Gregoire E, Youssef S, de Rooij D, de Bruin A, De Cian M, Chaboissier M
eLife 2020;9

Extracellular matrix-inducing Sox9 promotes both basal progenitor proliferation and gliogenesis in developing neocortex

Güven A, Kalebic N, Long K, Florio M, Vaid S, Brandl H, Stenzel D, Huttner W
eLife 2020;9

Epiphyseal Cartilage Formation Involves Differential Dynamics of Various Cellular Populations During Embryogenesis

Zhang Y, Annusver K, Sunadome K, Kameneva P, Edwards S, Lei G, Kasper M, Chagin A, Adameyko I, Xie M
Frontiers in Cell and Developmental Biology 2020;8

Caspase Inhibition Affects the Expression of Autophagy-Related Molecules in Chondrocytes

Vesela B, Svandova E, Ramesova A, Kratochvilova A, Tucker A, Matalova E
CARTILAGE 2020;13(2_suppl):956S-968S

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Krivanek J, Soldatov R, Kastriti M, Chontorotzea T, Herdina A, Petersen J, Szarowska B, Landova M, Matejova V, Holla L, Kuchler U, Zdrilic I, Vijaykumar A, Balic A, Marangoni P, Klein O, Neves V, Yianni V, Sharpe P, Harkany T, Metscher B, Bajénoff M, Mina M, Fried K, Kharchenko P, Adameyko I
Nature Communications 2020;11(1)

Robinow syndrome skeletal phenotypes caused by the WNT5AC83S variant are due to dominant interference with chondrogenesis

Gignac S, Hosseini-Farahabadi S, Akazawa T, Schuck N, Fu K, Richman J
Human Molecular Genetics 2019;28(14):2395-2414

N-methyl-D-aspartate (NMDA) receptor expression and function is required for early chondrogenesis

Matta C, Juhász T, Fodor J, Hajdú T, Katona É, Szűcs-Somogyi C, Takács R, Vágó J, Oláh T, Bartók Á, Varga Z, Panyi G, Csernoch L, Zákány R
Cell Communication and Signaling 2019;17(1)

The interconnection between cytokeratin and cell membrane-bound β-catenin in Sertoli cells derived from juvenile Xenopus tropicalis testes

Nguyen T, Vegrichtova M, Tlapakova T, Krulova M, Krylov V
Biology Open 2019

SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance

Yuan X, Li J, Coulouarn C, Lin T, Sulpice L, Bergeat D, De La Torre C, Liebe R, Gretz N, Ebert M, Dooley S, Weng H
British Journal of Cancer 2018;119(11):1358-1366

Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma.

Sumita Y, Yamazaki M, Maruyama S, Abé T, Cheng J, Takagi R, Tanuma JI
Oncology reports 2018 Nov;40(5):2487-2496

Evaluation of the effects of the combination of BMP‑2‑modified BMSCs and PRP on cartilage defects

Ruan S, Deng J, Yan L, Huang W
Experimental and Therapeutic Medicine 2018

Hyperbaric oxygen protects type II collagen in interleukin-1β-induced mandibular condylar chondrocyte via inhibiting the JNK/c-Jun signaling pathway

Sun Q, Wu G, Chen H, Chen L, Chen H, Zhu G, Zhao H
Oncotarget 2017;8(36):60312-60323

Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary

Minkina A, Lindeman R, Gearhart M, Chassot A, Chaboissier M, Ghyselinck N, Bardwell V, Zarkower D
Developmental Biology 2017;424(2):208-220

Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation

Landfors M, Johansen J, Aronsen J, Vågbø C, Doré L, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl J, Aanes H, Fußer M, Klungland A
Cell Discovery 2017;3(1)

A genomic atlas of human adrenal and gonad development

del Valle I, Buonocore F, Duncan A, Lin L, Barenco M, Parnaik R, Shah S, Hubank M, Gerrelli D, Achermann J
Wellcome Open Research 2017;2

Class I histone deacetylase inhibition improves pancreatitis outcome by limiting leukocyte recruitment and acinar‐to‐ductal metaplasia

Bombardo M, Saponara E, Malagola E, Chen R, Seleznik G, Haumaitre C, Quilichini E, Zabel A, Reding T, Graf R, Sonda S
British Journal of Pharmacology 2017;174(21):3865-3880

Superficial cells are self‐renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice

Li L, Newton P, Bouderlique T, Sejnohova M, Zikmund T, Kozhemyakina E, Xie M, Krivanek J, Kaiser J, Qian H, Dyachuk V, Lassar A, Warman M, Barenius B, Adameyko I, Chagin A
The FASEB Journal 2016;31(3):1067-1084

Sox9 expression in canine epithelial skin tumors

Fantinato E, Milani L, Sironi G
European Journal of Histochemistry 2015;59(3)

Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation

Roy N, Malik S, Villanueva K, Urano A, Lu X, Von Figura G, Seeley E, Dawson D, Collisson E, Hebrok M
Genes & Development 2015;29(6):658-671

Contribution of Mature Hepatocytes to Biliary Regeneration in Rats with Acute and Chronic Biliary Injury

Syn W, Chen Y, Chen H, Chien C, Wu S, Ho Y, Yu C, Chang M
PLOS ONE 2015;10(8):e0134327

Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure

Poulsen R, Knowles H, Carr A, Hulley P
Cell Death & Disease 2014;5(2):e1074-e1074

Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma

Capaccione K, Hong X, Morgan K, Liu W, Bishop M, Liu L, Markert E, Deen M, Minerowicz C, Bertino J, Allen T, Pine S
Oncotarget 2014;5(11):3636-3650

Prognostic Significance of β-Catenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series.

Bruun J, Kolberg M, Nesland JM, Svindland A, Nesbakken A, Lothe RA
Frontiers in oncology 2014;4:118

Evaluation of protein biomarkers of prostate cancer aggressiveness

Rizzardi A, Rosener N, Koopmeiners J, Isaksson Vogel R, Metzger G, Forster C, Marston L, Tiffany J, McCarthy J, Turley E, Warlick C, Henriksen J, Schmechel S
BMC Cancer 2014;14(1)

Three-dimensional reconstructions of intrahepatic bile duct tubulogenesis in human liver

Vestentoft P, Jelnes P, Hopkinson B, Vainer B, Møllgård K, Quistorff B, Bisgaard H
BMC Developmental Biology 2011;11(1)

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Enhanced validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Genetic validation
Main image
Experimental details: Western blot analysis in U-251MG cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-SOX9 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
Sample type: Human
Protocol: Protocol

Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human testis and skeletal muscle tissues using HPA001758 antibody. Corresponding SOX9 RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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