66513-1-Ig

antibody from Proteintech Group

Targeting: OLIG2 BHLHB1, bHLHe19, OLIGO2, PRKCBP2, RACK17

Provider product page for 66513-1-Ig

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [33]
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Product number: 66513-1-Ig - Provider product page
Provider: Proteintech Group
Product name: OLIG2 antibody
Antibody type: Monoclonal
Description: OLIG2 antibody (Cat. #66513-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1E8C5
Vial size: 20ul, 150ul

OLIG2 protein structure - 66513-1-Ig shown in red.

Submitted references Biomarkers for early detection and monitoring of abnormal brain development in mild fetal growth restriction.

Onoda A, Kitase Y, Coq JO, Ueda K, Shimizu S, Tsuji M, Hayakawa M, Sato Y
iScience 2025 Sep 19;28(9):113237

Targeting formyl peptide receptor 1 reduces brain inflammation and neurodegeneration.

Li Y, Li Z, Zheng P, Guan S, Li Y, Yao N, Qi Z, Zhang X, Su L, Jing J, Wu S, Zhao X, Wang M, Böttcher C, Ljunggren HG, Paul F, Van Kaer L, Verkhratsky A, Shi FD
Science (New York, N.Y.) 2025 Nov 13;390(6774):eadq1177

Baicalin and kaempferol alleviates cuprizone-induced demyelination and microglial activation by inhibiting the STAT3 and NF-κB signaling pathways.

Liu L, Zhao Y, Bu J, Peng S, Li Y, Su P, Li Y
International immunopharmacology 2025 May 8;154:114592

Paroxetine ameliorates corticosterone-induced myelin damage by promoting the proliferation and differentiation of oligodendrocyte precursor cells.

Bu J, Liu Y, Zhao Y, Liu L, Shen J, Li Y
Neuroscience 2025 May 7;573:344-354

Aging activates escape of the silent X chromosome in the female mouse hippocampus.

Gadek M, Shaw CK, Abdulai-Saiku S, Saloner R, Marino F, Wang D, Bonham LW, Yokoyama JS, Panning B, Benayoun BA, Casaletto KB, Ramani V, Dubal DB
Science advances 2025 Mar 7;11(10):eads8169

Astrocyte lactoferrin deficiency affects the construction and function of spinal neurons by regulating cholesterol metabolism.

Tong X, Liu X, Jiang YX, Su JR, Luan JQ, Guo C
Experimental cell research 2025 Jun 1;449(1):114595

Celastrol Mediated Regulation of the HnRNPA1-Thyroxine Axis in the Amygdala Alleviates High Fat Diet-Induced Demyelination and Cognitive Deficits in Mice.

Yao X, Zhang S, Zhang G, Liu Y, Zhu Y, Wang W, Zhu C, Lin N
Phytotherapy research : PTR 2025 Jul;39(7):3091-3104

DNMT3b-mediated CpA methylation facilitates REST binding and gene silencing and exacerbates hippocampal demyelination in diabetic mice.

Yao TF, Wang ZY, Sun L, Yu SX, Yu HD, Yang ZZ, Li WZ, Niu L, Sun D, Shi YH, Li JQ, Liu WQ, Liu XZ, Zuo ZF
The Journal of biological chemistry 2025 Feb;301(2):108137

Ferroptosis suppressor protein 1 regulated oligodendrocytes ferroptosis rescued by idebenone in spinal cord injury.

Fan B, Liu D, Qin J, Shi Z, Hu Z, Gao X, Ren Y, Zhao P, Chen X, Ren Y, Ning G, Liu T, Feng S
Free radical biology & medicine 2025 Feb 1;227:129-142

Hypoxia-induced TGFBI maintains glioma stem cells by stabilizing EphA2.

Chen Z, Wang J, Peng P, Liu G, Dong M, Zhang X, Zhang Y, Yang X, Wan L, Xiang W, Zhang S, Zhang B, Wu Q, Yu X, Wan F
Theranostics 2024;14(15):5778-5792

Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.

Zhou J, Zhang L, Peng J, Zhang X, Zhang F, Wu Y, Huang A, Du F, Liao Y, He Y, Xie Y, Gu L, Kuang C, Ou W, Xie M, Tu T, Pang J, Zhang D, Guo K, Feng Y, Yin S, Cao Y, Li T, Jiang Y
Cell metabolism 2024 Sep 3;36(9):2054-2068.e14

Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2.

Lv D, Dixit D, Cruz AF, Kim LJY, Duan L, Xu X, Wu Q, Zhong C, Lu C, Gersey ZC, Gimple RC, Xie Q, Yang K, Liu X, Fang X, Wu X, Kidwell RL, Wang X, Bao S, He HH, Locasale JW, Agnihotri S, Rich JN
Cell metabolism 2024 Nov 5;36(11):2419-2436.e8

Inhibition of GZMB activity ameliorates cognitive dysfunction by reducing demyelination in diabetic mice.

Yang ZZ, Liu WQ, Yu HD, Yu SX, Li YR, Wang YF, Yao TF, Li WZ, Sun D, Niu L, Liu XZ, Zuo ZF
Free radical biology & medicine 2024 Nov 20;225:53-62

Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in subarachnoid hemorrhage.

Mao J, Bao Y, Liu F, Ye Q, Peng J, Nie J, Huang L, Liao Y, Xing Y, Wu D, Wang K, Feng W, Qi S, Pan J, Qiu B
Journal of neuroinflammation 2024 Nov 19;21(1):302

Ring finger protein 216 loss-of-function induces white matter hyperintensities by inhibiting oligodendroglia proliferation.

Xu W, Chen K, Yuan Y, Guo M, Dong Q, Cui M
Cell biochemistry and function 2024 Jun;42(4):e4057

Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.

Li Y, Munoz-Mayorga D, Nie Y, Kang N, Tao Y, Lagerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L, Chen X
Cell metabolism 2024 Jun 4;36(6):1351-1370.e8

Exogenous NADPH could mitigate pyroptosis-induced brain injury in fetal mice exposed to gestational intermittent hypoxia.

Wei J, Zheng W, Teng C, An X, Li L, Zhong P, Peng C, Zhuge S, Akoto Ampadu J, Yu C, Cai X
International immunopharmacology 2024 Jun 30;135:112311

Selenoprotein W modulates tau homeostasis in an Alzheimer's disease mouse model.

Ren B, Situ J, Huang X, Tan Q, Xiao S, Li N, Tian J, Du X, Ni J, Liu Q
Communications biology 2024 Jul 17;7(1):872

EAAT3 impedes oligodendrocyte remyelination in chronic cerebral hypoperfusion-induced white matter injury.

Zhang Y, Ya D, Yang J, Jiang Y, Li X, Wang J, Tian N, Deng J, Yang B, Li Q, Liao R
CNS neuroscience & therapeutics 2024 Jan;30(1):e14487

TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA-PKcs.

Xu C, Chen G, Yu B, Sun B, Zhang Y, Zhang M, Yang Y, Xiao Y, Cheng SY, Li Y, Feng H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400023

Enriched environment treatment promotes neural functional recovery together with microglia polarization and remyelination after cerebral ischemia in rats.

Han Y, Shen X, Gao Z, Han P, Bi X
Brain research bulletin 2024 Apr;209:110912

Single-cell analysis of spinal cord injury reveals functional heterogeneity of oligodendrocyte lineage cells.

Wu Z, Li G, Wang S, Zhang N, Li X, Zhang F, Niu J, Wang N, Zu J, Wang Y
Gene 2023 Nov 30;886:147713

Remyelination in neuromyelitis optica spectrum disorder is promoted by edaravone through mTORC1 signaling activation.

Luo W, Xu H, Xu L, Jiang W, Chen C, Chang Y, Liu C, Tian Z, Qiu X, Xie C, Li X, Chen H, Lai S, Wu L, Cui Y, Tang C, Qiu W
Glia 2023 Feb;71(2):284-304

A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma.

Du X, Pang J, Gu B, Si T, Chang Y, Li T, Wu M, Wang Z, Wang Y, Feng J, Wu N, Man J, Li H, Li A, Zhang T, Wang B, Duan X
Nucleic acids research 2023 Feb 22;51(3):1050-1066

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Wang H, Devadoss D, Nair M, Chand HS, Lakshmana MK
Frontiers in cellular neuroscience 2022;16:954071

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Sun W, Wen M, Liu M, Wang Q, Liu Q, Li L, Siebert HC, Loers G, Zhang R, Zhang N
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Prognostic Value and Biological Function of Galectins in Malignant Glioma.

Zhu H, Liu D, Cheng L, Liu J, Wang G, Li H, Zhang Y, Mi H, Zhang S, Shu K, Yu X
Frontiers in oncology 2022;12:834307

Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.

Ye C, Li H, Li Y, Zhang Y, Liu G, Mi H, Li H, Xiao Q, Niu L, Yu X
iScience 2022 Sep 16;25(9):104872

A three-dimensional matrix system containing melatonin and neural stem cells repairs damage from traumatic brain injury in rats.

Fang XY, Zhao DW, Zhang C, Ge HF, Zhang XY, Zhao FC, Jiang YB, Feng H, Hu R
Neural regeneration research 2022 Nov;17(11):2512-2517

Single-Cell RNA Sequencing With Combined Use of Bulk RNA Sequencing to Reveal Cell Heterogeneity and Molecular Changes at Acute Stage of Ischemic Stroke in Mouse Cortex Penumbra Area.

Guo K, Luo J, Feng D, Wu L, Wang X, Xia L, Tao K, Wu X, Cui W, He Y, Wang B, Zhao Z, Zhang Z
Frontiers in cell and developmental biology 2021;9:624711

Shenzhiling oral liquid protects the myelin sheath against Alzheimer's disease through the PI3K/Akt-mTOR pathway.

Zheng M, Liu Z, Mana L, Qin G, Huang S, Gong Z, Tian M, He Y, Wang P
Journal of ethnopharmacology 2021 Oct 5;278:114264

Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage.

Sun XG, Zhang MM, Liu SY, Chu XH, Xue GQ, Zhang BC, Zhu JB, Godje Godje IS, Zhu LJ, Hu HY, Hai-Wang, Shen YJ, Wang GQ
Experimental neurology 2021 Jul;341:113692

Matrine protects oligodendrocytes by inhibiting their apoptosis and enhancing mitochondrial autophagy.

Wang MR, Zhang XJ, Liu HC, Ma WD, Zhang ML, Zhang Y, Li X, Dou MM, Jing YL, Chu YJ, Zhu L
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