Antibody data
- Antibody Data
- Antigen structure
- References [116]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
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- Product number
- 22280-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#22280-1-AP, RRID:AB_2736821
- Product name
- MYH7-specific antibody
- Antibody type
- Polyclonal
- Description
- MYH7-specific antibody (Cat. #22280-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2.
GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM).
Structural Diversity of 2-O-(β-d-Glucopyranosyl)benzyl Quinates from Casearia tardieuae and Their Anti-Myocardial Hypertrophy Activity in Rat Cardiomyocytes.
Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.
Salvia miltiorrhiza extract attenuates cardiorenal syndrome by inhibiting IL-1β mediated cross-talk between heart and kidney.
CTRP9 ameliorates heart failure with preserved ejection fraction by regulating lipid metabolism.
CELF1 Downregulation Promotes Cardiomyocyte Hypertrophy via Regulating Alternative Splicing of Tead1.
Sodium butyrate ameliorates muscle atrophy in type 2 diabetes-related sarcopenia via the PI3K/Akt/FoxO1 pathway.
Loss of STARD7 Impairs Mitochondrial Phospholipid Homeostasis and Contributes to Mitochondrial Myopathy.
WNT5B regulates myogenesis and fiber type conversion by affecting mRNA stability.
Reduced Muscle Force in Dystrophic DMDΔ52 Pigs Is Incompletely Restored by Systemic Transcript Reframing (DMDΔ51-52).
RNA-seq and ChIP-seq unveils thyroid hormone receptor α deficiency affects skeletal muscle myoblast proliferation and differentiation via Col6a1 during aging.
Indole-3-propionic acid enhances glycolytic myofiber formation in piglets through PI3K-mTOR activation and gut microbiota-driven tryptophan metabolic alteration.
Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.
Multi-Omics Insights into Postnatal Skeletal Muscle Development in Duroc Pigs.
Melatonin Activates AMPK Pathway to Regulate the Regeneration of Slow Muscle Fibers in Skeletal Muscle Injury Repair.
Development of an efficient mice model of cancer-associated cardiac cachexia.
YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes.
CACNB4 attenuates cardiac dysfunction by regulating calcium and ATP levels via interaction with RyR2.
Identification of novel biomarkers for hypertension and ventricular remodeling based on transcriptomics and machine learning.
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target.
Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways.
Conductive MeCbl/PEDOT:PSS/HA hydrogels with electrical stimulation for enhanced peripheral nerve regeneration.
PLK1 Downregulation Attenuates ET-1-Induced Cardiomyocyte Hypertrophy by Suppressing the ERK1/2 Pathway.
Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury.
LMOD2 interaction with ACTC1 regulates myogenic differentiation.
Cold Stress Regulates Muscle Development and Promotes Muscle Fiber Transformation by Regulating Mib1/Notch Pathway.
Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation.
Podocarpane and cleistanthane diterpenoids from Strophioblachia glandulosa: structural elucidation, anti-hypertrophy activity and network pharmacology.
Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice.
Development of a flexible 3D printed TPU-PVC microfluidic devices for organ-on-a-chip applications.
Sodium Butyrate Alleviates Heat Stress-Induced Oxidative Stress and Skeletal Muscle Homeostasis Disruption by Promoting Autophagy in Mice.
Bee venom alleviates isoproterenol-induced cardiac hypertrophy via JAK2/NF-κB signaling cascade.
Exercise alleviates programmed necrosis in myocardial ischemia-reperfusion injury through adipose tissue-derived exosomal miR-17-3p targeting CAMKII.
Functional characterization of a novel JPH2 variant (p.R160H) associated with dilated cardiomyopathy.
OTUB2 aggravates pathological cardiac hypertrophy through Rac1 activation.
GPCPD1 is regulated by METTL3/IGF2BP3 dependent m(6)A modification to affect pig muscle fiber type conversion.
O-GlcNAcylation modification of MyoD regulates skeletal muscle fiber differentiation by antagonizing the UPF1 pathway.
Inhibiting glycosphingolipids alleviates cardiac hypertrophy by reducing reactive oxygen species and restoring autophagic homeostasis.
Comprehensive analysis of disulfidptosis-related genes and the immune microenvironment in heart failure.
Light-phase time-restricted feeding disrupts the muscle clock and insulin sensitivity yet potentially induces muscle fiber remodeling in mice.
Time-restricted feeding relieves high temperature-induced impairment on meat quality by activating the Nrf2/HO-1 pathway, modification of muscle fiber composition, and enriching the polyunsaturated fatty acids in pigs.
The transcription factor PPARA mediates SIRT1 regulation of NCOR1 to protect damaged heart cells.
Mechanical Stress-Oxidative Stress Axis: Biological Basis in the Vaginal Wall and Pelvic Floor Muscles of Rats with Simulated Birth Injury.
Association of attenuated leptin signaling pathways with impaired cardiac function under prolonged high-altitude hypoxia.
Semaglutide ameliorates pressure overload-induced cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome.
Overexpressing of the GIPC1 protects against pathological cardiac remodelling.
Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart.
OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes.
STING activation in cardiomyocytes drives hypertrophy-associated heart failure via NF-κB-mediated inflammatory response.
Proteomic Profiling of SGLT-2 Inhibitor Canagliflozin in a Swine Model of Chronic Myocardial Ischemia.
The total xanthones extracted from Gentianella acuta alleviates HFpEF by activating the IRE1α/Xbp1s pathway.
Caprylic Acid Inhibits High Mobility Group Box-1-Induced Mitochondrial Damage in Myocardial Tubes.
CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1.
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway.
Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders.
CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis.
α-Ketoglutarate improves cardiac insufficiency through NAD(+)-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice.
JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKIIδ in cardiomyocytes.
Myogenic exosome miR-140-5p modulates skeletal muscle regeneration and injury repair by regulating muscle satellite cells.
Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes.
Regulation of myo-miR-24-3p on the Myogenesis and Fiber Type Transformation of Skeletal Muscle.
Mast Cells Contribute to Pressure Overload-Induced Myocardial Hypertrophy by Upregulating TRPV4 via Histamine: Role of Ca2+/ CnA/NFATc3 Signaling Pathway.
Qianyang yuyin granule ameliorates mitochondrial dysfunction of hypertensive myocardial remodeling.
Baicalin improves isoproterenol-induced cardiac remodeling by regulating the Nrf2-dependent signaling pathway.
Core biomarkers analysis benefit for diagnosis on human intrahepatic cholestasis of pregnancy.
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition.
Identification of different myofiber types in pigs muscles and construction of regulatory networks.
Identification of circRNA-miRNA-mRNA regulatory network and its role in cardiac hypertrophy.
Sodium Butyrate Ameliorates Type 2 Diabetes-Related Sarcopenia Through IL-33-Independent ILC2s/IL-13/STAT3 Signaling Pathway.
Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp.
Dietary Taurine Supplementation Improves the Meat Quality, Muscle Fiber Type, and Mitochondrial Function of Finishing Pigs.
SOX4 as a potential therapeutic target for pathological cardiac hypertrophy.
Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp.
GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy.
The Mouse CircGHR Regulates Proliferation, Differentiation and Apoptosis of Hepatocytes and Myoblasts.
"Biqi" Bayberry Extract Promotes Skeletal Muscle Fiber Type Remodeling by Increasing Fast Myofiber Formation via the Akt/FoxO1 Pathway in Mice.
Sacubitril/Valsartan Ameliorates Crizotinib-Induced Cardiotoxicity in Mice.
Endurance Exercise-Induced Fgf21 Promotes Skeletal Muscle Fiber Conversion through TGF-β1 and p38 MAPK Signaling Pathway.
Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation.
Toll-like receptor-2 in cardiomyocytes and macrophages mediates isoproterenol-induced cardiac inflammation and remodeling.
G9a inhibition promotes the formation of pacemaker-like cells by reducing the enrichment of H3K9me2 in the HCN4 promoter region.
Effect of morphological change on the maturation of human induced pluripotent stem cell-derived cardiac tissue in rotating flow culture.
Taurine promotes muscle fiber type transformation through CaN/NFATc1 signaling in porcine myoblasts.
Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response.
Super-enhancer-driven lncRNA Snhg7 aggravates cardiac hypertrophy via Tbx5/GLS2/ferroptosis axis.
An EGFP Knock-in Zebrafish Experimental Model Used in Evaluation of the Amantadine Drug Safety During Early Cardiogenesis.
Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.
Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling.
Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts.
Scutellarein protects against cardiac hypertrophy via suppressing TRAF2/NF-κB signaling pathway.
Engineering of thick human functional myocardium via static stretching and electrical stimulation.
ANGPTL8 is a negative regulator in pathological cardiac hypertrophy.
Loss of Myostatin Alters Mitochondrial Oxidative Phosphorylation, TCA Cycle Activity, and ATP Production in Skeletal Muscle.
Exercise-derived peptide protects against pathological cardiac remodeling.
TANK Promotes Pressure Overload Induced Cardiac Hypertrophy via Activating AKT Signaling Pathway.
Sleeve Gastrectomy Ameliorates Diabetes-Induced Cardiac Hypertrophy Correlates With the MAPK Signaling Pathway.
Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats.
YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy.
Generation of a homozygous MYH7 gene knockout human embryonic stem cell line (WAe009-A-69) using an episomal vector-based CRISPR/Cas9 system.
An MRTF-A-Sp1-PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy.
MYH7B variants cause hypertrophic cardiomyopathy by activating the CaMK-signaling pathway.
LonP1 regulates mitochondrial network remodeling through the PINK1/Parkin pathway during myoblast differentiation.
Comprehensive histological investigation of age-related changes in dermal extracellular matrix and muscle fibers in the upper lip vermilion.
Effect of Hypoxia on the Muscle Fiber Switching Signal Pathways CnA/NFATc1 and Myostatin in Mouse Myocytes.
Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo.
Sphingosine-1-phosphate ameliorates the cardiac hypertrophic response through inhibiting the activity of histone deacetylase-2.
Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.
Roles of Mitogen-Activating Protein Kinase Kinase Kinase Kinase-3 (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Regulation.
Proteomics of acute heart failure in a rat post-myocardial infarction model.
Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.
Excess Imidacloprid Exposure Causes the Heart Tube Malformation of Chick Embryos.
HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1.
MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells.
Zhao R, Cui X, Du H, Wang Z, Liu C, Zhang L, Qi J, Yang D, Yu H, Yan S, Liu W, Sun H, Wang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(17):e21337
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(17):e21337
GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM).
Tang N, Mu R, Wang H, Wu J, Zhang J, Huang D, Han Y, Li W, Chen Y, Li X, Sun Y, Zhang Z, Zuo J, Hu Y, Yin Y, Qu Y, Liu J, Jiao L, Liu X, Liang H, Wang N, Bai Y, Liu Y, Wang B, Zhao D, Liu Y, Yang B
Cell death and differentiation 2026 Mar 5;
Cell death and differentiation 2026 Mar 5;
Structural Diversity of 2-O-(β-d-Glucopyranosyl)benzyl Quinates from Casearia tardieuae and Their Anti-Myocardial Hypertrophy Activity in Rat Cardiomyocytes.
Zhang JJ, Zhang HY, Li N, Jiang F, Luo SZ, Xiao WL, Zheng CB, Li XL
Journal of agricultural and food chemistry 2026 Mar 4;74(8):6850-6863
Journal of agricultural and food chemistry 2026 Mar 4;74(8):6850-6863
Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.
Han L, Jing L, Zhu X, Li C, Bai L, Fang Y, Zhou Y, Bai D, Lu J, Han Y, Guo C, Zhou S, Yang Q
Journal of cachexia, sarcopenia and muscle 2026 Jun;17(3):e70295
Journal of cachexia, sarcopenia and muscle 2026 Jun;17(3):e70295
Salvia miltiorrhiza extract attenuates cardiorenal syndrome by inhibiting IL-1β mediated cross-talk between heart and kidney.
Wang M, Bai JQ, Cai J, Chen QQ, Wen XD, Qi LW, Zhang L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158060
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158060
CTRP9 ameliorates heart failure with preserved ejection fraction by regulating lipid metabolism.
Xin J, Liu R, Deng M, Song Y, Cui Y, Gao J, Zhang B, Feng L, Mu X, Cui J, Li H, Zhu L, Sun Y, Yi W
Journal of translational medicine 2026 Jan 7;24(1):228
Journal of translational medicine 2026 Jan 7;24(1):228
CELF1 Downregulation Promotes Cardiomyocyte Hypertrophy via Regulating Alternative Splicing of Tead1.
Hu L, Zhu K, Zeng S, Liu Y, Zhang S, Ni L
Genes 2026 Jan 29;17(2)
Genes 2026 Jan 29;17(2)
Sodium butyrate ameliorates muscle atrophy in type 2 diabetes-related sarcopenia via the PI3K/Akt/FoxO1 pathway.
Song CY, Yang Y, Hong K
Tissue & cell 2026 Aug;101:103487
Tissue & cell 2026 Aug;101:103487
Loss of STARD7 Impairs Mitochondrial Phospholipid Homeostasis and Contributes to Mitochondrial Myopathy.
Horibata Y, Sato T, Ohyama M, Yuyama S, Itoh M, Miura S, Konishi A, Sugimoto H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71777
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71777
WNT5B regulates myogenesis and fiber type conversion by affecting mRNA stability.
Fan D, Yao Y, Yan C, Li F, Yang Y, Xie B, Tang Z
International journal of biological sciences 2025;21(9):3934-3948
International journal of biological sciences 2025;21(9):3934-3948
Reduced Muscle Force in Dystrophic DMDΔ52 Pigs Is Incompletely Restored by Systemic Transcript Reframing (DMDΔ51-52).
Blasi M, Hristov H, Stöckl JB, Kraetzl M, Fiedler S, Kemter E, Kurome M, Kessler B, Cambra JM, Zakhartchenko V, Walter MC, Kupatt C, Klymiuk N, Fröhlich T, Blutke A, Stirm M, Jaudas F, Wolf E
Journal of cachexia, sarcopenia and muscle 2025;16(5):e70084
Journal of cachexia, sarcopenia and muscle 2025;16(5):e70084
RNA-seq and ChIP-seq unveils thyroid hormone receptor α deficiency affects skeletal muscle myoblast proliferation and differentiation via Col6a1 during aging.
Shi R, Chen G, Zhang Y, Zhang J, Yan L, Duan Y
Journal of muscle research and cell motility 2025 Sep;46(3):167-182
Journal of muscle research and cell motility 2025 Sep;46(3):167-182
Indole-3-propionic acid enhances glycolytic myofiber formation in piglets through PI3K-mTOR activation and gut microbiota-driven tryptophan metabolic alteration.
Kong Y, Wang Q, Wang J, Qiu X, Yang Y, Liu J, Yang F, Qi R
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Sep;22:363-374
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Sep;22:363-374
Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.
Zhang C, Song Y, Jin X, Xu Q, Ye H, Wu Z, Lin H, Hu J, Huang C, Zhou J, Lian J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e14659
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e14659
Multi-Omics Insights into Postnatal Skeletal Muscle Development in Duroc Pigs.
Wang K, Li X, Liu X, Liufu S, Xiao L, Chen B, Chen W, Jiang J, Liu Y, Ma H
Animals : an open access journal from MDPI 2025 Sep 16;15(18)
Animals : an open access journal from MDPI 2025 Sep 16;15(18)
Melatonin Activates AMPK Pathway to Regulate the Regeneration of Slow Muscle Fibers in Skeletal Muscle Injury Repair.
Xie W, Hong Z, Xie Y, Hou K, Li S, Fang M, Guan Y, Zhang Z, Zhang M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71123
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71123
Development of an efficient mice model of cancer-associated cardiac cachexia.
Xiong S, Zheng H, Wu T, Tan J, Huang T, Shen C, Ji Y, Liu M, Wan J, Cai W
Animal models and experimental medicine 2025 Nov;8(11):1960-1970
Animal models and experimental medicine 2025 Nov;8(11):1960-1970
YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes.
Zheng QS, Xiong YQ, Xu JC, Qian JF, Luo W, Wang QY, Zhao YN, Luo Y, Cui YQ, Fang Y, Guo XC, Chen DD, Wang Y, Liang G
Acta pharmacologica Sinica 2025 Nov;46(11):2938-2950
Acta pharmacologica Sinica 2025 Nov;46(11):2938-2950
CACNB4 attenuates cardiac dysfunction by regulating calcium and ATP levels via interaction with RyR2.
Jiang S, Hong M, Zhang J, Xu F, Zhang X, Zhang G
European journal of medical research 2025 Nov 5;30(1):1071
European journal of medical research 2025 Nov 5;30(1):1071
Identification of novel biomarkers for hypertension and ventricular remodeling based on transcriptomics and machine learning.
Li Z, Zhang B, Chao L, Tian X, Chen W, Liu C, Tian H
iScience 2025 Nov 21;28(11):113668
iScience 2025 Nov 21;28(11):113668
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
Lin K, Wei W, Chen S, Gong Y, Wang X, Wang M, Li R, Zhao Y, Xu S, Jin C, Jiang C, Fu G, Li Q
Cell death & disease 2025 May 22;16(1):409
Cell death & disease 2025 May 22;16(1):409
Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target.
Zuo X, Zhao R, Wu M, Wang Y, Wang S, Tang K, Wang Y, Chen J, Yan X, Cao Y, Li T
Nature aging 2025 Mar;5(3):419-436
Nature aging 2025 Mar;5(3):419-436
Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways.
Zhang M, Guan X, Dong Z, Yang C, Xiong C, Cheng W, Shang A, Liu Y, Guo X, Zhang B, Zhang B, Jin S, Qi W, Alexandrovna BT, Jiang Y, Du Z, Xu C
Clinical and translational medicine 2025 Mar;15(3):e70247
Clinical and translational medicine 2025 Mar;15(3):e70247
Conductive MeCbl/PEDOT:PSS/HA hydrogels with electrical stimulation for enhanced peripheral nerve regeneration.
Liu K, Shao J, Han B, Liu J, Yan S, Liu B, Liu Y
Materials today. Bio 2025 Jun;32:101755
Materials today. Bio 2025 Jun;32:101755
PLK1 Downregulation Attenuates ET-1-Induced Cardiomyocyte Hypertrophy by Suppressing the ERK1/2 Pathway.
Ding J, Yang A, Zhou L, Zhang F, Zhou H, Zhang Y, Wang Y, Liu Y, Liang D, Liu Y, Wu Y
Journal of cardiovascular translational research 2025 Jun;18(3):586-598
Journal of cardiovascular translational research 2025 Jun;18(3):586-598
Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury.
Zhuang X, Shi S, Liu S, Jiao Y, Huang B, Yang Y, Yang L, Yang X, Wang H, Liang C, Song D, Yu H, Zou D, Sun Q, Yang S, Yin C, Li J, Liu Y, Min J, Wang F, Nian Y, Du L, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2500566
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2500566
LMOD2 interaction with ACTC1 regulates myogenic differentiation.
Wang K, Liu C, Yi L, Liufu S, Chen W, Liu X, Chen B, Xu X, Liu J, Liu X, Yin Y, Ma H
BMC genomics 2025 Jul 31;26(1):709
BMC genomics 2025 Jul 31;26(1):709
Cold Stress Regulates Muscle Development and Promotes Muscle Fiber Transformation by Regulating Mib1/Notch Pathway.
Zheng M, Qi J, Wang X, Fu T, Chang Z, Zhao T, Sun Y, Lu J, Yan Y, Wang H
Frontiers in bioscience (Landmark edition) 2025 Jul 28;30(7):40141
Frontiers in bioscience (Landmark edition) 2025 Jul 28;30(7):40141
Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation.
Tan B, Hong L, Xiao L, Wu J, Lu G, Wang S, Liu L, Zheng E, Cai G, Li Z, Gu T, Wu Z
Nature communications 2025 Jul 1;16(1):5833
Nature communications 2025 Jul 1;16(1):5833
Podocarpane and cleistanthane diterpenoids from Strophioblachia glandulosa: structural elucidation, anti-hypertrophy activity and network pharmacology.
Wu XW, Huang YX, Li CJ, Li YF, Wang BB, Zeb MA, Xiao WL, Zheng CB, Li XL
Bioorganic chemistry 2025 Jan;154:108026
Bioorganic chemistry 2025 Jan;154:108026
Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice.
Sun S, Yu T, Huh JY, Cai Y, Yoon S, Javaid HMA
Skeletal muscle 2025 Jan 13;15(1):2
Skeletal muscle 2025 Jan 13;15(1):2
Development of a flexible 3D printed TPU-PVC microfluidic devices for organ-on-a-chip applications.
Kado Abdalkader R, Konishi S, Fujita T
Scientific reports 2025 Feb 19;15(1):6125
Scientific reports 2025 Feb 19;15(1):6125
Sodium Butyrate Alleviates Heat Stress-Induced Oxidative Stress and Skeletal Muscle Homeostasis Disruption by Promoting Autophagy in Mice.
Lu J, Li C, Zhao T, Li F, Yao Z, Dong Y, Gong Z, Yan Y, Luo X, Wang H
Nutrients 2025 Feb 15;17(4)
Nutrients 2025 Feb 15;17(4)
Bee venom alleviates isoproterenol-induced cardiac hypertrophy via JAK2/NF-κB signaling cascade.
Shi P, Han S, Sun Y, Li M, Xu X
Tissue & cell 2025 Dec;97:103077
Tissue & cell 2025 Dec;97:103077
Exercise alleviates programmed necrosis in myocardial ischemia-reperfusion injury through adipose tissue-derived exosomal miR-17-3p targeting CAMKII.
Liu Z, Lu W, He Y, Yu F
Archives of biochemistry and biophysics 2025 Dec;774:110640
Archives of biochemistry and biophysics 2025 Dec;774:110640
Functional characterization of a novel JPH2 variant (p.R160H) associated with dilated cardiomyopathy.
Jiao K, Gong K, Luo Y, Liu R, Wang L, Yao Y, Xie L
BMC cardiovascular disorders 2025 Dec 20;26(1):73
BMC cardiovascular disorders 2025 Dec 20;26(1):73
OTUB2 aggravates pathological cardiac hypertrophy through Rac1 activation.
Xing J, Lin L, Zhao Y, Shen Z, Wei Y, Xue X, Qin F, Liu H
Human cell 2025 Dec 2;39(1):17
Human cell 2025 Dec 2;39(1):17
GPCPD1 is regulated by METTL3/IGF2BP3 dependent m(6)A modification to affect pig muscle fiber type conversion.
Yang Y, Tan B, Xiao L, Huang H, Xu W, Su J, Zhao Y, Hong L, Cai G, Li Z, Dai L, Gu T
Gene 2025 Aug 20;962:149578
Gene 2025 Aug 20;962:149578
O-GlcNAcylation modification of MyoD regulates skeletal muscle fiber differentiation by antagonizing the UPF1 pathway.
Kou L, Zhang M, Li X, Zhang Z, Guo W, Zhang B, Yang P, Xia Y, Wang H, Xu B, Li S
The Journal of biological chemistry 2025 Apr;301(4):108364
The Journal of biological chemistry 2025 Apr;301(4):108364
Inhibiting glycosphingolipids alleviates cardiac hypertrophy by reducing reactive oxygen species and restoring autophagic homeostasis.
Jiang C, Tan M, Lai L, Wang Y, Chen Z, Xie Q, Li Y
Frontiers in pharmacology 2024;15:1409625
Frontiers in pharmacology 2024;15:1409625
Comprehensive analysis of disulfidptosis-related genes and the immune microenvironment in heart failure.
Zhao L, Zhang J, Song Q, Dai C, Qin Y, Li A
Frontiers in cell and developmental biology 2024;12:1516898
Frontiers in cell and developmental biology 2024;12:1516898
Light-phase time-restricted feeding disrupts the muscle clock and insulin sensitivity yet potentially induces muscle fiber remodeling in mice.
Ye Z, Huang K, Dai X, Gao D, Gu Y, Qian J, Zhang F, Zhai Q
Heliyon 2024 Sep 30;10(18):e37475
Heliyon 2024 Sep 30;10(18):e37475
Time-restricted feeding relieves high temperature-induced impairment on meat quality by activating the Nrf2/HO-1 pathway, modification of muscle fiber composition, and enriching the polyunsaturated fatty acids in pigs.
Li Z, Wang Y, Yuan P, Zhu Y, Hu P, Song T, Liu R, Liu HY, Cai D
Stress biology 2024 Sep 14;4(1):39
Stress biology 2024 Sep 14;4(1):39
The transcription factor PPARA mediates SIRT1 regulation of NCOR1 to protect damaged heart cells.
Wang M, Zhou F, Luo Y, Deng X, Chen X, Yi Q
Cardiovascular diagnosis and therapy 2024 Oct 31;14(5):832-847
Cardiovascular diagnosis and therapy 2024 Oct 31;14(5):832-847
Mechanical Stress-Oxidative Stress Axis: Biological Basis in the Vaginal Wall and Pelvic Floor Muscles of Rats with Simulated Birth Injury.
Wang Q, Wu X, Wang S, Xie B, Sun X, Wang J
International urogynecology journal 2024 Nov;35(11):2141-2152
International urogynecology journal 2024 Nov;35(11):2141-2152
Association of attenuated leptin signaling pathways with impaired cardiac function under prolonged high-altitude hypoxia.
Wang J, Liu S, Sun L, Kong Z, Chai J, Wen J, Tian X, Chen N, Xu C
Scientific reports 2024 May 3;14(1):10206
Scientific reports 2024 May 3;14(1):10206
Semaglutide ameliorates pressure overload-induced cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome.
He W, Wei J, Liu X, Zhang Z, Huang R, Jiang Z
Scientific reports 2024 May 23;14(1):11824
Scientific reports 2024 May 23;14(1):11824
Overexpressing of the GIPC1 protects against pathological cardiac remodelling.
Sun X, Han Y, Yu Y, Chen Y, Dong C, Lv Y, Qu H, Fan Z, Yu Y, Sang Y, Tang W, Liu Y, Ju J, Zhao D, Bai Y
European journal of pharmacology 2024 May 15;971:176488
European journal of pharmacology 2024 May 15;971:176488
Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart.
Lv Q, Li D, Zhao L, Yu P, Tao Y, Zhu Q, Wang Y, Wang M, Fu G, Shang M, Zhang W
Science advances 2024 May 10;10(19):eadl3549
Science advances 2024 May 10;10(19):eadl3549
OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes.
Wang Q, Liang S, Qian J, Xu J, Zheng Q, Wang M, Guo X, Min J, Wu G, Zhuang Z, Luo W, Liang G
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167018
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167018
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Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):166997
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):166997
Proteomic Profiling of SGLT-2 Inhibitor Canagliflozin in a Swine Model of Chronic Myocardial Ischemia.
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Biomedicines 2024 Mar 6;12(3)
Biomedicines 2024 Mar 6;12(3)
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Zhao L, Qin Y, Liu Y, An L, Liu W, Zhang C, Song Q, Dai C, Zhang J, Li A
Journal of cellular and molecular medicine 2024 Jun;28(11):e18466
Journal of cellular and molecular medicine 2024 Jun;28(11):e18466
Caprylic Acid Inhibits High Mobility Group Box-1-Induced Mitochondrial Damage in Myocardial Tubes.
Nukaga S, Fujiwara-Tani R, Nishida R, Miyagawa Y, Goto K, Kawahara I, Nakashima C, Fujii K, Ogata R, Ohmori H, Kuniyasu H
International journal of molecular sciences 2024 Jul 24;25(15)
International journal of molecular sciences 2024 Jul 24;25(15)
CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1.
Mei S, Ma X, Zhou L, Wuyun Q, Wang J, Xiao Q, Wang M, Zhang K, Chen C, Yan J, Ding H
iScience 2024 Jul 19;27(7):110200
iScience 2024 Jul 19;27(7):110200
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway.
Lv C, Zhou L, Meng Y, Yuan H, Geng J
Cellular signalling 2024 Jan;113:110974
Cellular signalling 2024 Jan;113:110974
Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders.
Gao S, Zhao X, Leng Y, Xia Z
Scientific reports 2024 Jan 28;14(1):2328
Scientific reports 2024 Jan 28;14(1):2328
CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis.
Shi L, Tan Y, Zheng W, Cao G, Zhou H, Li P, Cui J, Song Y, Feng L, Li H, Shan W, Zhang B, Yi W
Cell death discovery 2024 Jan 26;10(1):53
Cell death discovery 2024 Jan 26;10(1):53
α-Ketoglutarate improves cardiac insufficiency through NAD(+)-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice.
Yu H, Gan D, Luo Z, Yang Q, An D, Zhang H, Hu Y, Ma Z, Zeng Q, Xu D, Ren H
Molecular medicine (Cambridge, Mass.) 2024 Jan 22;30(1):15
Molecular medicine (Cambridge, Mass.) 2024 Jan 22;30(1):15
JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKIIδ in cardiomyocytes.
Xu J, Liang S, Wang Q, Zheng Q, Wang M, Qian J, Yu T, Lou S, Luo W, Zhou H, Liang G
Cellular and molecular life sciences : CMLS 2024 Jan 10;81(1):18
Cellular and molecular life sciences : CMLS 2024 Jan 10;81(1):18
Myogenic exosome miR-140-5p modulates skeletal muscle regeneration and injury repair by regulating muscle satellite cells.
Cao X, Xue L, Yu X, Yan Y, Lu J, Luo X, Wang H, Wang J
Aging 2024 Feb 29;16(5):4609-4630
Aging 2024 Feb 29;16(5):4609-4630
Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes.
Fu Q, Yuan J, Yang TH, Su JH, Zhang JJ, Wu XW, Zhang HY, Xiao WL, Zheng CB, Li XL
Journal of natural products 2024 Feb 23;87(2):297-303
Journal of natural products 2024 Feb 23;87(2):297-303
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Fan D, Yao Y, Liu Y, Yan C, Li F, Wang S, Yu M, Xie B, Tang Z
Genes 2024 Feb 21;15(3)
Genes 2024 Feb 21;15(3)
Mast Cells Contribute to Pressure Overload-Induced Myocardial Hypertrophy by Upregulating TRPV4 via Histamine: Role of Ca2+/ CnA/NFATc3 Signaling Pathway.
Zhang ZD, Lian T, Cheng QY, Zhu MP, Lv JF
Current medical science 2024 Dec;44(6):1071-1080
Current medical science 2024 Dec;44(6):1071-1080
Qianyang yuyin granule ameliorates mitochondrial dysfunction of hypertensive myocardial remodeling.
Zheng Y, Fang Y, Luo Y, Fan Y, Fang Z
Journal of ethnopharmacology 2024 Dec 5;335:118610
Journal of ethnopharmacology 2024 Dec 5;335:118610
Baicalin improves isoproterenol-induced cardiac remodeling by regulating the Nrf2-dependent signaling pathway.
Qian K, Song L, Guo JM, Fu D, Shi J, Ma Y, Ge ZJ, Li L, Zhang SQ
BMC cardiovascular disorders 2024 Dec 20;24(1):733
BMC cardiovascular disorders 2024 Dec 20;24(1):733
Core biomarkers analysis benefit for diagnosis on human intrahepatic cholestasis of pregnancy.
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BMC pregnancy and childbirth 2024 Aug 10;24(1):525
BMC pregnancy and childbirth 2024 Aug 10;24(1):525
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Wu Q, Liu WJ, Ma XY, Chang JS, Zhao XY, Liu YH, Yu XY
Acta pharmacologica Sinica 2024 Apr;45(4):738-750
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BMC genomics 2024 Apr 24;25(1):400
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PloS one 2023;18(3):e0279638
PloS one 2023;18(3):e0279638
Sodium Butyrate Ameliorates Type 2 Diabetes-Related Sarcopenia Through IL-33-Independent ILC2s/IL-13/STAT3 Signaling Pathway.
Cao Y, Li Y, Han W, Jia X, Zhu P, Wei B, Cong X, Wang Z
Journal of inflammation research 2023;16:343-358
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Neininger-Castro AC, Hayes JB Jr, Sanchez ZC, Taneja N, Fenix AM, Moparthi S, Vassilopoulos S, Burnette DT
bioRxiv : the preprint server for biology 2023 Oct 6;
bioRxiv : the preprint server for biology 2023 Oct 6;
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Journal of agricultural and food chemistry 2023 Oct 18;71(41):15331-15340
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European journal of pharmacology 2023 Nov 5;958:176071
European journal of pharmacology 2023 Nov 5;958:176071
Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp.
Neininger-Castro AC, Hayes JB, Sanchez ZC, Taneja N, Fenix AM, Moparthi S, Vassilopoulos S, Burnette DT
eLife 2023 Nov 3;12
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114324
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The Mouse CircGHR Regulates Proliferation, Differentiation and Apoptosis of Hepatocytes and Myoblasts.
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Genes 2023 May 31;14(6)
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"Biqi" Bayberry Extract Promotes Skeletal Muscle Fiber Type Remodeling by Increasing Fast Myofiber Formation via the Akt/FoxO1 Pathway in Mice.
Li J, Li Y, Suo X, Li J, Huang D, Kou G
Foods (Basel, Switzerland) 2023 Jun 23;12(13)
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International journal of molecular sciences 2023 Jul 13;24(14)
International journal of molecular sciences 2023 Jul 13;24(14)
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Zou J, Wang W, Lu Y, Ayala J, Dong K, Zhou H, Wang J, Chen W, Weintraub NL, Zhou J, Li J, Su H
Cell reports 2023 Jan 31;42(1):112018
Cell reports 2023 Jan 31;42(1):112018
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22740
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22740
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Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
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Regenerative therapy 2023 Dec;24:479-488
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European journal of pharmacology 2023 Aug 15;953:175822
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Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.
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International journal of biological sciences 2022;18(5):2018-2031
International journal of biological sciences 2022;18(5):2018-2031
Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling.
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Developmental cell 2022 Oct 24;57(20):2397-2411.e9
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Molecular biology reports 2022 Mar;49(3):2085-2095
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Cell death & disease 2022 Jul 18;13(7):621
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International journal of molecular sciences 2022 Dec 11;23(24)
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Frontiers in cardiovascular medicine 2021;8:687540
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Frontiers in physiology 2021;12:785799
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 22280-1-AP( MYH7 Antibody) at dilution of 1:2000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The MYH7-specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human MYH7-specific. This antibody recognizes human, mouse antigen. The MYH7-specific antibody has been validated for the following applications: ELISA, IHC, WB, IP analysis.