14018-1-AP

antibody from Proteintech Group

Targeting: BACH1 BACH-1, BTBD24

Provider product page for 14018-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [68]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 14018-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14018-1-AP, RRID:AB_2274498
Product name: BACH1 antibody
Antibody type: Polyclonal
Description: KD/KO validated BACH1 antibody (Cat. #14018-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

BACH1 protein structure - 14018-1-AP shown in red.

Submitted references Mechanism of Bushen Wenyang Huayu Formula against oxidative damage by Let-7b-Bach1 in the treatment of endometriosis.

Zhang Y, Luo L, Liu L, Hu S, Niu R, Xi Y, Liu Q, Wu S, Sun Y, Zhao J, Zhang Y, He M
Journal of ethnopharmacology 2026 May 23;363:121392

A multi-omic approach reveals iron availability influences cell fate fidelity.

Ong AJS, Tigani TA, Gomes AJ, Reinecke JM, Cox AG, Brown KK
npj metabolic health and disease 2026 Mar 6;4(1)

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia.

Lewis AC, Gruber E, Franich R, Armstrong J, Kelly MJ, Opazo CM, Low YC, Flippe L, Wijanarko K, Rowe CL, Mawal CH, Birrell A, So J, Vaidyanathan S, Ting K, Semcesen LN, Last K, Ang CS, Pomilio G, Brown FC, Wei AH, Powell JA, Ng ES, Frazier AE, McArthur K, Lalaoui N, Stroud DA, Brown KK, Johnstone RW, Kats LM
Cell 2026 Jan 8;189(1):215-232.e24

BPC157 drives angiogenesis through FBXO22-dependent stabilization of BACH1.

Zhang J, Liu M, Ou H, Wang Z, He L, Xiao Y, Xie F, Yu D, Cao H, He W, Wang S, Zhang W, Zhang K, Zhang Y, Li M, Hao Q
Cell communication and signaling : CCS 2026 Jan 29;24(1)

BACH1 is stabilized by vitamin E and attenuates the formation of hypertrophic scar through the Wnt/β-catenin pathway.

Luan W, Fan S, Jiang H, Jiang D, Yang J, He L
Burns : journal of the International Society for Burn Injuries 2026 Feb;52(1):107807

The interplay between hormonal vitamin D and lipopolysaccharide signaling on human neutrophil transcriptional responses.

Ismailova A, Salehi-Tabar R, Ismailova N, Dumas O, Saliba J, Blank V, White JH
Frontiers in immunology 2025;16:1683913

Identification of a BACH1 lung cancer signature: A novel tool for understanding BACH1 biology and identifying new inhibitors.

Klenja-Skudrinja D, Ali KX, Walker D, Higgins M, Patel AA, Raj D, Creelman A, McDowall C, Taylor C, Wenta T, Larsson E, Wiel C, Sayin VI, de la Vega L
Redox biology 2025 Sep;85:103789

Yangxinshi tablet protects against myocardial injury and increases skeletal muscle exercise capacity by regulating mitochondrial bioenergetics.

Song H, Liu C, Yang Z, Liu D, Li J, Mei Z, Xu J, Pan J, Zhang X, Yan C, Han Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156990

The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1.

Mao F, Wu S, Allison DB, He D, Kong Y, Li C, Li Z, Zhang Y, Wang X, Zhang Q, Wang C, Liu X
PLoS biology 2025 Nov;23(11):e3003490

Fatty acid-binding protein 4 drives microglia-mediated neuroinflammation through promoting S100A9 expression and lipid droplet accumulation after intracerebral hemorrhage.

He J, Qin Z, Liu H, Cai Y, Wu H, Wang T, Hu Q, Xu Y, Yang P, Wu X, Qu Y, Guo W
Journal of neuroinflammation 2025 Nov 7;22(1):263

Renal expression and clinical significance of Bach1-related oxidative stress indicators in patients with chronic glomerulonephritis.

Zhang H, Li XL, Lu JY, Ke Q, Li J, Du Y, Yu YF
Pathology, research and practice 2025 May;269:155935

Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance.

Lei G, Sun M, Cheng J, Ye R, Lu Z, Horbath A, Huo D, Wu S, Alapati A, Aggarwal S, Xu Z, Mao C, Yan Y, Yao J, Li Q, Chen X, Lee H, Zhuang L, Jiang D, Pataer A, Roth JA, Navin N, Koong AC, You MJ, Lin SH, Gan B
Cancer cell 2025 Jun 9;43(6):1076-1092.e5

Heshuxiaoji pill suppresses steatohepatitis and fibrosis by regulating the AngII-BACH1 mediated vasoconstriction.

Pu Y, Ren W, Gan Z, Wang S, Peng M, Yue R, Huang R
Journal of ethnopharmacology 2025 Jun 26;350:119989

Bach1 Deficiency Ameliorates Radiation Pneumonitis via Activating TFAM Signaling Pathway.

Huang J, Zhang Y, Jiang F, Zhang Y, Li S, He S, Sun J, Chen D, Pang Q, Wu Y
Antioxidants & redox signaling 2025 Jul;43(1-3):75-91

Acquisition mechanism of heme oxygenase-1 induction by heat shock in human monocytic cell line THP-1 after differentiation to macrophage-like cells.

Tsuji D, Ishida N, Miyamoto T, Inouye S, Akagi R
Journal of biochemistry 2025 Jul 31;178(2):135-143

Deficiency of BTB and CNC homology 1 promotes colon tumorigenesis by enhancing intestinal epithelial cell proliferation in mice.

Kanamaru K, Tanikawa J, Takagi T, Muto A, Igarashi K, Naito Y, Higashimura Y
Bioscience, biotechnology, and biochemistry 2025 Jul 23;89(8):1120-1127

High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis.

Zou P, Li T, Cao Z, Yang E, Bao M, Zhang H, Zhang Z, Liu D, Zhang M, Gao X, Ge J, Jiang X, Tian Z, Luo P
Cell death discovery 2025 Feb 5;11(1):46

Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity.

Lin Z, Li Y, Wu Z, Liu Q, Li X, Luo W
Journal of nanobiotechnology 2025 Feb 14;23(1):109

Piceatannol-3'-O-β-D-glucopyranoside inhibits neuroexcitotoxicity and ferroptosis through NMDAR/NRF2/BACH1/ACSL4 pathway in acute ischemic stroke.

Fan G, Liu J, Liu M, Huang Y
Free radical biology & medicine 2025 Feb 1;227:667-679

THBru ameliorates atherosclerosis by inhibiting endothelial ferroptosis via regulation of the super-enhancer-associated ABCC1.

Feng J, Hu Y, Sun X, Hao Y, Li Y, Huang Q, Xie Y, Gao J, Hu A, Hong Y, Wang X, Liu H, Dou Z, Yao L, Lu Q, Wang J, Kopylov P, Han W, Zhang Y, Liu X
Acta pharmaceutica Sinica. B 2025 Dec;15(12):6461-6477

The interplay of sleep deprivation, ferroptosis, and BACH1 in cardiovascular disease pathogenesis.

Wu Z, Huang X, Lu X, Cao Y
Tissue & cell 2025 Aug;95:102848

Effect of ultrasound-microbubble exposure on acute myeloid leukemia cancer cell proteome.

Stilwell J, Savaya DA, Sakarya E, Ferworn C, Cloves E, Botelho RJ, Antonescu CN, Karshafian R
Scientific reports 2025 Aug 14;15(1):29817

MAFF alleviates hepatic ischemia-reperfusion injury by regulating the CLCF1/STAT3 signaling pathway.

Lei D, Wang Y, Li S, Xiang S, Luo Y, Yan P, Luo F, Huang Z, Wu Z
Cellular & molecular biology letters 2025 Apr 1;30(1):39

ZNF131-BACH1 transcriptionally accelerates RAD51-dependent homologous recombination repair and therapy-resistance of non-small-lung cancer cells by preventing their degradation from CUL3.

Fan M, Liu Q, Ma X, Jiang Y, Wang Y, Jia S, Nie Y, Deng R, Zhou P, Zhang S, Jiang S, Guan M, Hou Y, Miao Y, Zhang Y, Zhang X
Theranostics 2024;14(18):7241-7264

BTB and CNC homology 1 deficiency disrupts intestinal IgA secretion through regulation of polymeric immunoglobulin receptor expression.

Hamada R, Yonezawa A, Matsumoto K, Mitani T, Takagi T, Muto A, Igarashi K, Naito Y, Higashimura Y
American journal of physiology. Gastrointestinal and liver physiology 2024 Sep 1;327(3):G414-G423

Remifentanil represses oxidative stress to relieve hepatic ischemia/reperfusion injury via regulating BACH1/PRDX1 axis.

You Y, Chen S, Deng H, Xing X, Tang B, Wu Y, Lei E
Clinics and research in hepatology and gastroenterology 2024 Oct;48(8):102422

Disruption of BACH1 Protects AC16 Cardiomyocytes Against Hypoxia/Reoxygenation-Evoked Injury by Diminishing CDKN3 Transcription.

Li Y, Zhou Y, Pei H, Li D
Cardiovascular toxicology 2024 Oct;24(10):1105-1115

FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1.

Zeng H, Xu J, Wu R, Wang X, Jiang Y, Wang Q, Guo J, Xiao F
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167307

PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer.

Nguyen CDK, Colón-Emeric BA, Murakami S, Shujath MNY, Yi C
Cell reports 2024 May 28;43(5):114176

Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress.

Yuan Z, Li J, Xiao F, Wu Y, Zhang Z, Shi J, Qian J, Wu X, Yan F
International journal of oral science 2024 May 11;16(1):38

Thermosensitive gel-nano system against esophageal cancer via restoring p53 activity and boosting T-cell immunity.

Gong K, Lin J, Chen X, Duan Y, Zhang J, Yu J, Wang J, Sun R, Li J, Duan Y
Journal of controlled release : official journal of the Controlled Release Society 2024 Jul;371:111-125

BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility.

Amaral EP, Namasivayam S, Queiroz ATL, Fukutani E, Hilligan KL, Aberman K, Fisher L, Bomfim CCB, Kauffman K, Buchanan J, Santuo L, Gazzinelli-Guimaraes PH, Costa DL, Teixeira MA, Barreto-Duarte B, Rocha CG, Santana MF, Cordeiro-Santos M, Barber DL, Wilkinson RJ, Kramnik I, Igarashi K, Scriba T, Mayer-Barber KD, Andrade BB, Sher A
Nature microbiology 2024 Jan;9(1):120-135

Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells.

Liu CX, Gao Y, Xu XF, Jin X, Zhang Y, Xu Q, Ding HX, Li BJ, Du FK, Li LC, Zhong MW, Zhu JK, Zhang GY
World journal of gastroenterology 2024 Feb 7;30(5):485-498

RTA408 alleviates lipopolysaccharide-induced acute lung injury via inhibiting Bach1-mediated ferroptosis.

Wu Y, Zhang Y, Ge L, He S, Zhang Y, Chen D, Nie Y, Zhu M, Pang Q
International immunopharmacology 2024 Dec 5;142(Pt B):113250

Dual BACH1 regulation by complementary SCF-type E3 ligases.

Goretzki B, Khoshouei M, Schröder M, Penner P, Egger L, Stephan C, Argoti D, Dierlamm N, Rada JM, Kapps S, Müller CS, Thiel Z, Mutlu M, Tschopp C, Furkert D, Freuler F, Haenni S, Tenaillon L, Knapp B, Hinniger A, Hoppe P, Schmidt E, Gutmann S, Iurlaro M, Ryzhakov G, Fernández C
Cell 2024 Dec 26;187(26):7585-7602.e25

BACH1 impairs hepatocyte regeneration after hepatectomy with repeated ischemia/reperfusion by reprogramming energy metabolism and exacerbating oxidative stress.

Hu Y, Li J, Hu L, Liu F, Chen R, Xu L, Tang Z, Lu B, Yu J
Biochemical pharmacology 2024 Aug;226:116377

δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis.

He X, Wang D, Yi Y, Tan Y, Wu M, Wang H, Hu W, Chen H, Zhang Q, Wu Y
Cell death discovery 2023 Sep 22;9(1):349

Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer.

Zhang L, Liang J, Qin H, Lv Y, Liu X, Li Z, Chao Z, Jia C, Qin X, Zhang H
Journal of experimental & clinical cancer research : CR 2023 Nov 10;42(1):296

BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.

Guo J, Qiu J, Jia M, Li Q, Wei X, Li L, Pan Q, Jin J, Ge F, Ma S, He Y, Lin J, Li Y, Ma J, Jiang N, Zhi X, Jiang L, Zhang J, Osto E, Jing Q, Wang X, Meng D
Nucleic acids research 2023 May 22;51(9):4284-4301

Bach1 modulates AKT3 transcription to participate in hyperglycaemia-mediated EndMT in vascular endothelial cells.

Meng Z, Shen W, Yu L, Tong F, He H, Hu Y, Wu W, Liu J
Clinical and experimental pharmacology & physiology 2023 Jun;50(6):443-452

BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.

Yao B, Cai Y, Wan L, Deng J, Zhao L, Wang W, Han Z
The journal of gene medicine 2023 Jun;25(6):e3488

Hyperforin Enhances Heme Oxygenase-1 Expression Triggering Lipid Peroxidation in BRAF-Mutated Melanoma Cells and Hampers the Expression of Pro-Metastatic Markers.

Cardile A, Passarini C, Zanrè V, Fiore A, Menegazzi M
Antioxidants (Basel, Switzerland) 2023 Jun 30;12(7)

Regulation of DNA damage response by trimeric G-proteins.

Abd El-Hafeez AA, Sun N, Chakraborty A, Ear J, Roy S, Chamarthi P, Rajapakse N, Das S, Luker KE, Hazra TK, Luker GD, Ghosh P
iScience 2023 Feb 17;26(2):105973

The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency.

Ge MK, Zhang C, Zhang N, He P, Cai HY, Li S, Wu S, Chu XL, Zhang YX, Ma HM, Xia L, Yang S, Yu JX, Yao SY, Zhou XL, Su B, Chen GQ, Shen SM
Cell metabolism 2023 Dec 5;35(12):2216-2230.e8

BACH1 controls hepatic insulin signaling and glucose homeostasis in mice.

Jin J, He Y, Guo J, Pan Q, Wei X, Xu C, Qi Z, Li Q, Ma S, Lin J, Jiang N, Ma J, Wang X, Jiang L, Ding Q, Osto E, Zhi X, Meng D
Nature communications 2023 Dec 21;14(1):8428

Protective effect of tin chloride on rhabdomyolysis-induced acute kidney injury in rats.

Ohtani S, Shimizu H, Yamaoka M, Takahashi T, Omori E, Morimatsu H
PloS one 2022;17(3):e0265512

The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.

Zhao Y, Song J, Dong W, Liu X, Yang C, Wang D, Xue Y, Ruan X, Liu L, Wang P, Zhang M, Liu Y
Cell death & disease 2022 Sep 5;13(9):767

Glucose Increases Hepatic Mitochondrial Antioxidant Enzyme Activities in Insulin Resistant Rats Following Chronic Angiotensin Receptor Blockade.

Godoy-Lugo JA, Thorwald MA, Mendez DA, Rodriguez R, Nakano D, Nishiyama A, Ortiz RM
International journal of molecular sciences 2022 Sep 17;23(18)

BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells.

Liu C, Yu J, Liu B, Liu M, Song G, Zhu L, Peng B
BMC oral health 2022 Nov 24;22(1):536

MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis.

Shiozaki Y, Miyazaki-Anzai S, Keenan AL, Miyazaki M
Autophagy 2022 May;18(5):1049-1061

The SETD8/ELK1/bach1 complex regulates hyperglycaemia-mediated EndMT in diabetic nephropathy.

Li X, Lu L, Hou W, Wang F, Huang T, Meng Z, Zhu M
Journal of translational medicine 2022 Mar 29;20(1):147

Interplay of Nrf2 and BACH1 in inducing ferroportin expression and enhancing resistance of human macrophages towards ferroptosis.

Namgaladze D, Fuhrmann DC, Brüne B
Cell death discovery 2022 Jul 19;8(1):327

G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes.

Li C, Yin Z, Xiao R, Huang B, Cui Y, Wang H, Xiang Y, Wang L, Lei L, Ye J, Li T, Zhong Y, Guo F, Xia Y, Fang P, Liang K
Genome biology 2022 Dec 15;23(1):259

Single-Cell Analysis Identify Transcription Factor BACH1 as a Master Regulator Gene in Vascular Cells During Aging.

Ge F, Pan Q, Qin Y, Jia M, Ruan C, Wei X, Jing Q, Zhi X, Wang X, Jiang L, Osto E, Guo J, Meng D
Frontiers in cell and developmental biology 2021;9:786496

MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2.

Sun M, Guo M, Ma G, Zhang N, Pan F, Fan X, Wang R
Toxicology and applied pharmacology 2021 Sep 1;426:115637

PTEN deficiency facilitates the therapeutic vulnerability to proteasome inhibitor bortezomib in gallbladder cancer.

Jiang TY, Feng XF, Fang Z, Cui XW, Lin YK, Pan YF, Yang C, Ding ZW, Zhang YJ, Tan YX, Wang HY, Dong LW
Cancer letters 2021 Mar 31;501:187-199

Role of the Transcription Factor BTB and CNC Homology 1 in a Rat Model of Acute Liver Injury Induced by Experimental Endotoxemia.

Tanioka N, Shimizu H, Omori E, Takahashi T, Yamaoka M, Morimatsu H
Acta medica Okayama 2021 Jun;75(3):363-372

Defective BACH1/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells.

Chillappagari S, Garapati V, Mahavadi P, Naehrlich L, Schmeck BT, Schmitz ML, Guenther A
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2021 Jan;20(1):140-148

Heme oxygenase-1 induction by heat shock in rat hepatoma cell line is regulated by the coordinated function of HSF1, NRF2 and BACH1.

Akagi R, Kubo T, Hatori Y, Miyamoto T, Inouye S
Journal of biochemistry 2021 Dec 4;170(4):501-510

PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.

Jiang TY, Pan YF, Wan ZH, Lin YK, Zhu B, Yuan ZG, Ma YH, Shi YY, Zeng TM, Dong LW, Tan YX, Wang HY
Science translational medicine 2020 Sep 23;12(562)

Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.

You L, Chen J, Liu W, Xiang Q, Luo Z, Wang W, Xu W, Wu K, Zhang Q, Liu Y, Wu J
Virulence 2020 Dec;11(1):537-553

Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.

Yang P, Zhou Y, Xia Q, Yao L, Chang X
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727

S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells.

Tsuneyoshi T, Kunimura K, Morihara N
Nitric oxide : biology and chemistry 2019 Mar 1;84:22-29

microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia.

Tili E, Mezache L, Michaille JJ, Amann V, Williams J, Vandiver P, Quinonez M, Fadda P, Mikhail A, Nuovo G
Annals of diagnostic pathology 2018 Jun;34:103-109

Dynamic changes in Bach1 expression in the kidney of rhabdomyolysis-associated acute kidney injury.

Yamaoka M, Shimizu H, Takahashi T, Omori E, Morimatsu H
PloS one 2017;12(7):e0180934

The electrophilic character of quinones is essential for the suppression of Bach1.

Su C, Liu Z, Wang Y, Wang Y, Song E, Song Y
Toxicology 2017 Jul 15;387:17-26

Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.

Su C, Shi Q, Song X, Fu J, Liu Z, Wang Y, Wang Y, Xia X, Song E, Song Y
Toxicology 2016 Jul 1;363-364:48-57

Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway.

Kwok SC
International journal of cell biology 2013;2013:162094

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 14018-1-AP(BACH1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human cervical cancer using 14018-1-AP(BACH1 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The BACH1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BACH1. This antibody recognizes human,mouse,rat antigen. The BACH1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 14018-1-AP.pdf

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