NB100-1268

Hirukawa A, Smith HW, Zuo D, Dufour CR, Savage P, Bertos N, Johnson RM, Bui T, Bourque G, Basik M, Giguère V, Park M, Muller WJ
Nature communications 2018 Jun 29;9(1):2547

Phosphorylcholine-based stealthy nanocapsules enabling tumor microenvironment-responsive doxorubicin release for tumor suppression.

Liu G, Tsai HI, Zeng X, Zuo Y, Tao W, Han J, Mei L
Theranostics 2017;7(5):1192-1203

A mouse model of aniridia reveals the in vivo downstream targets of Pax6 driving iris and ciliary body development in the eye.

Wang X, Shan X, Gregory-Evans CY
Biochimica et biophysica acta. Molecular basis of disease 2017 Jan;1863(1):60-67

Yap and Taz play a crucial role in neural crest-derived craniofacial development.

Wang J, Xiao Y, Hsu CW, Martinez-Traverso IM, Zhang M, Bai Y, Ishii M, Maxson RE, Olson EN, Dickinson ME, Wythe JD, Martin JF
Development (Cambridge, England) 2016 Feb 1;143(3):504-15

Foxc1 is required by pericytes during fetal brain angiogenesis.

Siegenthaler JA, Choe Y, Patterson KP, Hsieh I, Li D, Jaminet SC, Daneman R, Kume T, Huang EJ, Pleasure SJ
Biology open 2013 Jul 15;2(7):647-59

Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells.

Hayashi H, Kume T
PloS one 2008 Jun 11;3(6):e2401

FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A.

Berry FB, Skarie JM, Mirzayans F, Fortin Y, Hudson TJ, Raymond V, Link BA, Walter MA
Human molecular genetics 2008 Feb 15;17(4):490-505

Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development.

Zarbalis K, Siegenthaler JA, Choe Y, May SR, Peterson AS, Pleasure SJ
Proceedings of the National Academy of Sciences of the United States of America 2007 Aug 28;104(35):14002-7

FGF19 is a target for FOXC1 regulation in ciliary body-derived cells.

Tamimi Y, Skarie JM, Footz T, Berry FB, Link BA, Walter MA
Human molecular genetics 2006 Nov 1;15(21):3229-40

Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis.

Berry FB, Lines MA, Oas JM, Footz T, Underhill DA, Gage PJ, Walter MA
Human molecular genetics 2006 Mar 15;15(6):905-19

Identification of FOXC1 as a TGF-beta1 responsive gene and its involvement in negative regulation of cell growth.

Zhou Y, Kato H, Asanoma K, Kondo H, Arima T, Kato K, Matsuda T, Wake N
Genomics 2002 Nov;80(5):465-72

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: FoxC1 Antibody [NB100-1268] - HEK293 lysate (10 ug protein in RIPA buffer) over expressing Human FOXC1 with DYKDDDDK tag probed with FOXC1 Antibody (1 ug/mL) in Lane A and probed with anti-DYKDDDDK Tag (1/3000) in lane C. Mock-transfected HEK293 probed with FOXC1 Antibody (1 mg/mL) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunocytochemistry/Immunofluorescence

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Flow Cytometry: FoxC1 Antibody [NB100-1268] - Paraformaldehyde fixed HEK293 cells (blue line), permeabilized with 0.5% Triton. Primary antibody at 10 ug/mL, 1 hr incubation, followed by Alexa Fluor 488 secondary antibody at 2 ug/mL. IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.