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- References [119]
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- Product number
- 17563-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17563-1-AP, RRID:AB_2178659
- Product name
- RIP3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RIP3 antibody (Cat. #17563-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Shikonin and chitosan-silver nanoparticles synergize against triple-negative breast cancer through RIPK3-triggered necroptotic immunogenic cell death.
Ferroptosis induced by plasma-activated Ringer's lactate solution prevents oral cancer progression.
Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1.
Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy.
Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation.
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis.
Targeting P2Y(14)R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitis.
NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
Electroacupuncture Inhibits Neuroinflammation Induced by Astrocytic Necroptosis Through RIP1/MLKL/TLR4 Pathway in a Mouse Model of Spinal Cord Injury.
The cGAS/STING signaling pathway is involved in sevoflurane induced neuronal necroptosis via regulating microglia M1 polarization.
An investigation of the distributions of ferroptosis and necroptosis mediators in the maternal-fetal interface at different days of rat pregnancy.
The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells.
RIPK3 activation promotes DAXX-dependent neuronal necroptosis after intracerebral hemorrhage in mice.
The traditional herb Sargentodoxa cuneata alleviates DSS-induced colitis by attenuating epithelial barrier damage via blocking necroptotic signaling.
Knockdown of BCL-3 Attenuates Inflammatory Response in Intracerebral Hemorrhage Through an rBMECs/MGs Microenvironment.
SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus.
Xinyang tablet alleviated cardiac dysfunction in a cardiac pressure overload model by regulating the receptor-interacting serum/three-protein kinase 3/FUN14 domain containing 1-mediated mitochondrial unfolded protein response and mitophagy.
Phosphoproteomics Reveals Novel Insights into the Pathogenesis and Identifies New Therapeutic Kinase Targets of Ulcerative Colitis.
Pimpinellin ameliorates macrophage inflammation by promoting RNF146-mediated PARP1 ubiquitination.
Nanointegrative Glycoengineering-Activated Necroptosis of Triple Negative Breast Cancer Stem Cells Enables Self-Amplifiable Immunotherapy for Systemic Tumor Rejection.
HIST3H2A promotes the progression of prostate cancer through inhibiting cell necroptosis.
Lovastatin/SN38 co-loaded liposomes amplified ICB therapeutic effect via remodeling the immunologically-cold colon tumor and synergized stimulation of cGAS-STING pathway.
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.
Induction of RIPK3/MLKL-mediated necroptosis by Erigeron breviscapus injection exhibits potent antitumor effect.
N-acetyl-L-cysteine alleviated the oxidative stress-induced inflammation and necroptosis caused by excessive NiCl(2) in primary spleen lymphocytes.
Fe(III)-Shikonin supramolecular nanomedicines as immunogenic cell death stimulants and multifunctional immunoadjuvants for tumor vaccination.
Brazilin inhibits bladder cancer by promoting cell necroptosis.
A natural chalcone cardamonin inhibits necroptosis and ameliorates dextran sulfate sodium (DSS)-induced colitis by targeting RIPK1/3 kinases.
PEDF inhibits LPS-induced acute lung injury in rats and promotes lung epithelial cell survival by upregulating PPAR-γ.
Protective Effect of a Novel RIPK1 Inhibitor, Compound 4-155, in Systemic Inflammatory Response Syndrome and Sepsis.
Effect of doramectin on programmed cell death pathway in glioma cells.
LncRNA MALAT1 Promoted Neuronal Necroptosis in Cerebral Ischemia-reperfusion Mice by Stabilizing HSP90.
p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells.
Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage.
Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy.
Identification of necroptosis-related gene TRAF5 as potential target of diagnosing atherosclerosis and assessing its stability.
Cisatracurium besylate rescues Mycobacterium Tuberculosis-infected macrophages from necroptosis and enhances the bactericidal effect of isoniazid.
Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease.
Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis.
A Mitochondrion-Targeting Protein (B2) Primes ROS/Nrf2-Mediated Stress Signals, Triggering Apoptosis and Necroptosis in Lung Cancer.
Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis.
Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1.
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.
Role of SESTRIN2/AMPK/ULK1 pathway activation and lysosomes dysfunction in NaAsO(2)-induced liver injury under oxidative stress.
Ameliorative effects of epigallocatechin-3-gallate nanoparticles on 2,4-dinitrochlorobenzene induced atopic dermatitis: A potential mechanism of inflammation-related necroptosis.
Blue Light Induces RPE Cell Necroptosis, Which Can Be Inhibited by Minocycline.
Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors.
Necrosulfonamide Alleviates Acute Brain Injury of Intracerebral Hemorrhage via Inhibiting Inflammation and Necroptosis.
Porphyromonas gingivalis lipopolysaccharide induced RIPK3/MLKL-mediated necroptosis of oral epithelial cells and the further regulation in macrophage activation.
A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma.
Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease.
New insights of necroptosis and immune infiltration in sepsis-induced myocardial dysfunction from bioinformatics analysis through RNA-seq in mice.
Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.
Mesenchymal Stem Cells-Derived Exosomes Ameliorate Ischemia/Reperfusion Induced Acute Kidney Injury in a Porcine Model.
Protective effect of inhibiting necroptosis on gentamicin-induced nephrotoxicity.
Central nervous system stimulants promote nerve cell death under continuous hypoxia.
Novel pharmacological inhibition of JMJD3 improves necrotizing enterocolitis by attenuating the inflammatory response and ameliorating intestinal injury.
Study of the synergistic effect of singlet oxygen with other plasma-generated ROS in fungi inactivation during water disinfection.
Tea polyphenols alleviates acetochlor-induced apoptosis and necroptosis via ROS/MAPK/NF-κB signaling in Ctenopharyngodon idellus kidney cells.
Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance.
Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.
LRG-1 promotes fat graft survival through the RAB31-mediated inhibition of hypoxia-induced apoptosis.
Sperm-Associated Antigen 9 Promotes Influenza A Virus-Induced Cell Death via the c-Jun N-Terminal Kinase Signaling Pathway.
LncRNA 122049 suppresses apoptosis of renal tubular epithelial cells in ischemic AKI by targeting the miR-330-5p/ELK1 axis.
Selenium Deficiency Induces Apoptosis and Necroptosis Through ROS/MAPK Signal in Human Uterine Smooth Muscle Cells.
RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage.
Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis.
Protective Effect of MFG-E8 on Necroptosis-Induced Intestinal Inflammation and Enteroendocrine Cell Function in Diabetes.
The role of KIAA1191 in the necroptotic pathway of multiple myeloma.
Salmonella pSLT-encoded effector SpvB promotes RIPK3-dependent necroptosis in intestinal epithelial cells.
Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis.
Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line.
Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification.
Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.
Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis.
Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19.
Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro.
RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus.
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.
ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency.
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice.
Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway.
Pterocephin A, a novel Triterpenoid Saponin from Pterocephalus hookeri induced liver injury by activation of necroptosis.
Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer.
Deficiency of NEAT1 prevented MPP(+)-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis.
CB1R Promotes Chronic Alcohol-Induced Neuronal Necroptosis in Mice Prefrontal Cortex.
The Performance of HepG2 and HepaRG Systems through the Glass of Acetaminophen-Induced Toxicity.
Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation.
Cadmium exposure induces TNF-α-mediated necroptosis via FPR2/TGF-β/NF-κB pathway in swine myocardium.
M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.
Coxsackievirus A6 Induces Necroptosis for Viral Production.
Combination of Rapamycin and MK-2206 Induced Cell Death via Autophagy and Necroptosis in MYCN-Amplified Neuroblastoma Cell Lines.
Cryptotanshinone protects dextran sulfate sodium-induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation.
Pharmacological activation of CB2 receptor protects against ethanol-induced myocardial injury related to RIP1/RIP3/MLKL-mediated necroptosis.
Protective effect of astaxanthin against SnS(2) nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
Necroptosis mediated by impaired autophagy flux contributes to adverse ventricular remodeling after myocardial infarction.
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Raman micro-spectroscopy monitoring of cytochrome c redox state in Candida utilis during cell death under low-temperature plasma-induced oxidative stress.
SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States.
Protective effect of dabrafenib on renal ischemia-reperfusion injury in vivo and in vitro.
Necrostatin-1 Alleviates Bleomycin-Induced Pulmonary Fibrosis and Extracellular Matrix Expression in Interstitial Pulmonary Fibrosis.
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.
MUC1 downregulation promotes TNF-α-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway.
Necrostatin-1 Attenuates Renal Ischemia and Reperfusion Injury via Meditation of HIF-1α/mir-26a/TRPC6/PARP1 Signaling.
Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
PEDF decreases cardiomyocyte edema during oxygen‑glucose deprivation and recovery via inhibiting lactate accumulation and expression of AQP1.
Evaluation of the Liver Toxicity of Pterocephalus hookeri Extract via Triggering Necrosis.
A "Hibernating-Like" Viable State Induced by Lentiviral Vector-Mediated Pigment Epithelium-Derived Factor Overexpression in Rat Acute Ischemic Myocardium.
Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation.
Necroptosis and Apoptosis Contribute to Cisplatin and Aminoglycoside Ototoxicity.
Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis.
Selenoprotein S silencing triggers mouse hepatoma cells apoptosis and necrosis involving in intracellular calcium imbalance and ROS-mPTP-ATP.
Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis.
Receptor-Interacting Protein 3/Caspase-8 May Regulate Inflammatory Response and Promote Tissue Regeneration in the Periodontal Microenvironment.
TNF-α increases Staphylococcus aureus-induced death of human alveolar epithelial cell line A549 associated with RIP3-mediated necroptosis.
Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice.
Liang J, Tian X, Zhou M, Yan F, Fan J, Qin Y, Chen B, Huo X, Yu Z, Tian Y, Deng S, Peng Y, Wang Y, Liu B, Ma X
Biomaterials 2024 Sep;309:122608
Biomaterials 2024 Sep;309:122608
Ferroptosis induced by plasma-activated Ringer's lactate solution prevents oral cancer progression.
Sato K, Yang M, Nakamura K, Tanaka H, Hori M, Nishio M, Suzuki A, Hibi H, Toyokuni S
Oral diseases 2024 Sep;30(6):3912-3924
Oral diseases 2024 Sep;30(6):3912-3924
Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1.
Chiu HW, Chou CL, Lee KT, Shih CC, Huang TH, Sung LC
International journal of biological macromolecules 2024 May;268(Pt 2):131779
International journal of biological macromolecules 2024 May;268(Pt 2):131779
Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy.
Jiang S, Ma F, Lou J, Li J, Shang X, Li Y, Wu J, Xu S
European journal of pharmacology 2024 May 5;970:176455
European journal of pharmacology 2024 May 5;970:176455
Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation.
Kang H, Hu Q, Yang Y, Huang G, Li J, Zhao X, Zhu L, Su H, Tang W, Wan M
ACS nano 2024 May 28;18(21):13885-13898
ACS nano 2024 May 28;18(21):13885-13898
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis.
Peng F, Liao M, Jin W, Liu W, Li Z, Fan Z, Zou L, Chen S, Zhu L, Zhao Q, Zhan G, Ouyang L, Peng C, Han B, Zhang J, Fu L
Signal transduction and targeted therapy 2024 May 15;9(1):133
Signal transduction and targeted therapy 2024 May 15;9(1):133
Targeting P2Y(14)R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitis.
Liu C, Wang H, Han L, Zhu Y, Ni S, Zhi J, Yang X, Zhi J, Sheng T, Li H, Hu Q
Nature communications 2024 Mar 7;15(1):2083
Nature communications 2024 Mar 7;15(1):2083
NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
Zhu J, Li J, Yang K, Chen Y, Wang J, He Y, Shen K, Wang K, Shi T, Chen W
Cancer letters 2024 Mar 31;585:216693
Cancer letters 2024 Mar 31;585:216693
Electroacupuncture Inhibits Neuroinflammation Induced by Astrocytic Necroptosis Through RIP1/MLKL/TLR4 Pathway in a Mouse Model of Spinal Cord Injury.
Zhao H, Zong X, Li L, Li N, Liu C, Zhang W, Li J, Yang C, Huang S
Molecular neurobiology 2024 Jun;61(6):3258-3271
Molecular neurobiology 2024 Jun;61(6):3258-3271
The cGAS/STING signaling pathway is involved in sevoflurane induced neuronal necroptosis via regulating microglia M1 polarization.
Zhang Q, Li Y, Liu Y, Wang X, Yang Y, Shi L
Cellular signalling 2024 Jul;119:111195
Cellular signalling 2024 Jul;119:111195
An investigation of the distributions of ferroptosis and necroptosis mediators in the maternal-fetal interface at different days of rat pregnancy.
Tatar M, Tüfekci KK
Anatomia, histologia, embryologia 2024 Jan;53(1):e12991
Anatomia, histologia, embryologia 2024 Jan;53(1):e12991
The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells.
Li J, Tang M, Ke RX, Li PL, Sheng ZG, Zhu BZ
Toxicology and applied pharmacology 2024 Jan;482:116765
Toxicology and applied pharmacology 2024 Jan;482:116765
RIPK3 activation promotes DAXX-dependent neuronal necroptosis after intracerebral hemorrhage in mice.
Bai Q, Wang S, Rao D, Zhou Z, Wang J, Wang Q, Qin Y, Chu Z, Zhao S, Yu D, Xu Y
CNS neuroscience & therapeutics 2024 Jan;30(1):e14397
CNS neuroscience & therapeutics 2024 Jan;30(1):e14397
The traditional herb Sargentodoxa cuneata alleviates DSS-induced colitis by attenuating epithelial barrier damage via blocking necroptotic signaling.
Wang Y, Zhang B, Liu S, Xu E, Wang Z
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117373
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117373
Knockdown of BCL-3 Attenuates Inflammatory Response in Intracerebral Hemorrhage Through an rBMECs/MGs Microenvironment.
Ma J, Yin H, Ran Z, Luo T, Jin Z, Zheng L, Zhang F
Neuroscience 2024 Jan 26;537:105-115
Neuroscience 2024 Jan 26;537:105-115
SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus.
Ye X, Lin JY, Chen LX, Wu XC, Ma KJ, Li BX, Fang YX
Heliyon 2024 Jan 15;10(1):e23945
Heliyon 2024 Jan 15;10(1):e23945
Xinyang tablet alleviated cardiac dysfunction in a cardiac pressure overload model by regulating the receptor-interacting serum/three-protein kinase 3/FUN14 domain containing 1-mediated mitochondrial unfolded protein response and mitophagy.
Dong X, Zhuang HW, Wen RJ, Huang YS, Liang BX, Li H, Xian SX, Li C, Wang LJ, Wang JY
Journal of ethnopharmacology 2024 Aug 10;330:118152
Journal of ethnopharmacology 2024 Aug 10;330:118152
Phosphoproteomics Reveals Novel Insights into the Pathogenesis and Identifies New Therapeutic Kinase Targets of Ulcerative Colitis.
Tao S, Long X, Gong P, Yu X, Tian L
Inflammatory bowel diseases 2024 Aug 1;30(8):1367-1378
Inflammatory bowel diseases 2024 Aug 1;30(8):1367-1378
Pimpinellin ameliorates macrophage inflammation by promoting RNF146-mediated PARP1 ubiquitination.
Yang L, Du M, Liu K, Wang P, Zhu J, Li F, Wang Z, Huang K, Liang M
Phytotherapy research : PTR 2024 Apr;38(4):1783-1798
Phytotherapy research : PTR 2024 Apr;38(4):1783-1798
Nanointegrative Glycoengineering-Activated Necroptosis of Triple Negative Breast Cancer Stem Cells Enables Self-Amplifiable Immunotherapy for Systemic Tumor Rejection.
Zhao Y, Li Y, He J, Li M, Yao X, Yang H, Luo Z, Luo P, Su M
Advanced healthcare materials 2024 Apr;13(9):e2303337
Advanced healthcare materials 2024 Apr;13(9):e2303337
HIST3H2A promotes the progression of prostate cancer through inhibiting cell necroptosis.
Yang L, Ruan Y, Xu H
BMC cancer 2024 Apr 29;24(1):544
BMC cancer 2024 Apr 29;24(1):544
Lovastatin/SN38 co-loaded liposomes amplified ICB therapeutic effect via remodeling the immunologically-cold colon tumor and synergized stimulation of cGAS-STING pathway.
Yang Y, Qi J, Hu J, Zhou Y, Zheng J, Deng W, Inam M, Guo J, Xie Y, Li Y, Xu C, Deng W, Chen W
Cancer letters 2024 Apr 28;588:216765
Cancer letters 2024 Apr 28;588:216765
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.
Cai Y, Chen X, Lu T, Fang X, Ding M, Yu Z, Hu S, Liu J, Zhou X, Wang X
International journal of biological sciences 2023;19(14):4627-4643
International journal of biological sciences 2023;19(14):4627-4643
Induction of RIPK3/MLKL-mediated necroptosis by Erigeron breviscapus injection exhibits potent antitumor effect.
Guo X, Li R, Cui J, Hu C, Yu H, Ren L, Cheng Y, Jiang J, Ding X, Wang L
Frontiers in pharmacology 2023;14:1219362
Frontiers in pharmacology 2023;14:1219362
N-acetyl-L-cysteine alleviated the oxidative stress-induced inflammation and necroptosis caused by excessive NiCl(2) in primary spleen lymphocytes.
Zhang X, Xu L, Ma W, Shi B, Liu Q, Song Y, Fang C, Liu P, Qiao S, Cai J, Zhang Z
Frontiers in immunology 2023;14:1146645
Frontiers in immunology 2023;14:1146645
Fe(III)-Shikonin supramolecular nanomedicines as immunogenic cell death stimulants and multifunctional immunoadjuvants for tumor vaccination.
Feng W, Shi W, Cui Y, Xu J, Liu S, Gao H, Zhu S, Liu Y, Zhang H
Theranostics 2023;13(15):5266-5289
Theranostics 2023;13(15):5266-5289
Brazilin inhibits bladder cancer by promoting cell necroptosis.
Yang X, Zhang S, He J, Zhao L, Chen L, Yang Y, Wang J, Yan L, Zhang T
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):738-748
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):738-748
A natural chalcone cardamonin inhibits necroptosis and ameliorates dextran sulfate sodium (DSS)-induced colitis by targeting RIPK1/3 kinases.
Shen X, Chen H, Wen T, Liu L, Yang Y, Xie F, Wang L
European journal of pharmacology 2023 Sep 5;954:175840
European journal of pharmacology 2023 Sep 5;954:175840
PEDF inhibits LPS-induced acute lung injury in rats and promotes lung epithelial cell survival by upregulating PPAR-γ.
Xu L, Chen Y, Feng S, Liu Z, Ye Y, Zhou R, Liu L
BMC pulmonary medicine 2023 Sep 23;23(1):359
BMC pulmonary medicine 2023 Sep 23;23(1):359
Protective Effect of a Novel RIPK1 Inhibitor, Compound 4-155, in Systemic Inflammatory Response Syndrome and Sepsis.
Ling ZY, Lv QZ, Li J, Lu RY, Chen LL, Xu WH, Wang Y, Zhuang CL
Inflammation 2023 Oct;46(5):1796-1809
Inflammation 2023 Oct;46(5):1796-1809
Effect of doramectin on programmed cell death pathway in glioma cells.
Du S, Liang H, Zhou L, Chen C, Sun R, Zhang J, Meng X, Gao A
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 Oct;25(10):2871-2883
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 Oct;25(10):2871-2883
LncRNA MALAT1 Promoted Neuronal Necroptosis in Cerebral Ischemia-reperfusion Mice by Stabilizing HSP90.
Huang S, Hou D, Zhang L, Pei C, Liang J, Li J, Yang G, Yu D
Neurochemical research 2023 Nov;48(11):3457-3471
Neurochemical research 2023 Nov;48(11):3457-3471
p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells.
Li X, Xiong W, Wang Y, Li Y, Cheng X, Liu W
Laboratory investigation; a journal of technical methods and pathology 2023 May;103(5):100058
Laboratory investigation; a journal of technical methods and pathology 2023 May;103(5):100058
Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage.
Qiu X, Tao Q, Zhang L, Kuang C, Xie Y, Zhang L, Yin S, Peng J, Jiang Y
Journal of neurochemistry 2023 Mar;164(6):829-846
Journal of neurochemistry 2023 Mar;164(6):829-846
Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy.
Sun K, Guo Z, Zhang J, Hou L, Liang S, Lu F, Wang G, Xu J, Zhang X, Guo F, Zhu W
Cell death discovery 2023 Mar 31;9(1):109
Cell death discovery 2023 Mar 31;9(1):109
Identification of necroptosis-related gene TRAF5 as potential target of diagnosing atherosclerosis and assessing its stability.
Peng Z, Wang K, Wang S, Wu R, Yao C
BMC medical genomics 2023 Jun 17;16(1):139
BMC medical genomics 2023 Jun 17;16(1):139
Cisatracurium besylate rescues Mycobacterium Tuberculosis-infected macrophages from necroptosis and enhances the bactericidal effect of isoniazid.
Wen Q, Zhang J, Zhang Z, Chen L, Liu H, Han Z, Chen Y, Wang K, Liu J, Sai N, Zhou X, Zhou C, Hu S, Ma L
International immunopharmacology 2023 Jul;120:110291
International immunopharmacology 2023 Jul;120:110291
Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease.
Zhou M, Zhi J, Zhi J, Xiong Z, Wu F, Lu Y, Hu Q
International journal of biological macromolecules 2023 Jul 31;244:125373
International journal of biological macromolecules 2023 Jul 31;244:125373
Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis.
Wang L, Yan H, Chen X, Han L, Liu G, Yang H, Lu D, Liu W, Che C
Journal of microbiology and biotechnology 2023 Jan 28;33(1):43-50
Journal of microbiology and biotechnology 2023 Jan 28;33(1):43-50
A Mitochondrion-Targeting Protein (B2) Primes ROS/Nrf2-Mediated Stress Signals, Triggering Apoptosis and Necroptosis in Lung Cancer.
Chiu HW, Hung SW, Chiu CF, Hong JR
Biomedicines 2023 Jan 11;11(1)
Biomedicines 2023 Jan 11;11(1)
Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis.
Liu WC, Chiu HW, Chou CL, Chiu YJ, Lee YH
Environmental pollution (Barking, Essex : 1987) 2023 Feb 1;318:120871
Environmental pollution (Barking, Essex : 1987) 2023 Feb 1;318:120871
Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1.
Wang ZW, Zou FM, Wang AL, Yang J, Jin R, Wang BL, Shen LJ, Qi S, Liu J, Liu J, Wang WC, Liu QS
Acta pharmacologica Sinica 2023 Apr;44(4):801-810
Acta pharmacologica Sinica 2023 Apr;44(4):801-810
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.
Zhou G, Wu H, Yang J, Ye M, Liu D, Li Y, Zhang D, Zhang J, Yang Q, Liu Y
Cardiovascular toxicology 2023 Apr;23(3-4):161-175
Cardiovascular toxicology 2023 Apr;23(3-4):161-175
Role of SESTRIN2/AMPK/ULK1 pathway activation and lysosomes dysfunction in NaAsO(2)-induced liver injury under oxidative stress.
Bi D, Zheng D, Shi M, Hu Q, Wang H, Zhi H, Lou D, Zhang A, Hu Y
Ecotoxicology and environmental safety 2023 Apr 1;254:114751
Ecotoxicology and environmental safety 2023 Apr 1;254:114751
Ameliorative effects of epigallocatechin-3-gallate nanoparticles on 2,4-dinitrochlorobenzene induced atopic dermatitis: A potential mechanism of inflammation-related necroptosis.
Han M, Wang X, Wang J, Lang D, Xia X, Jia Y, Chen Y
Frontiers in nutrition 2022;9:953646
Frontiers in nutrition 2022;9:953646
Blue Light Induces RPE Cell Necroptosis, Which Can Be Inhibited by Minocycline.
Song W, Zhu R, Gao W, Xing C, Yang L
Frontiers in medicine 2022;9:831463
Frontiers in medicine 2022;9:831463
Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors.
Zhang M, Wang L, Liu W, Wang T, De Sanctis F, Zhu L, Zhang G, Cheng J, Cao Q, Zhou J, Tagliabue A, Bronte V, Yan D, Wan X, Yu G
Journal of immunology research 2022;2022:2253436
Journal of immunology research 2022;2022:2253436
Necrosulfonamide Alleviates Acute Brain Injury of Intracerebral Hemorrhage via Inhibiting Inflammation and Necroptosis.
Zhang X, Zhang Y, Wang F, Liu Y, Yong VW, Xue M
Frontiers in molecular neuroscience 2022;15:916249
Frontiers in molecular neuroscience 2022;15:916249
Porphyromonas gingivalis lipopolysaccharide induced RIPK3/MLKL-mediated necroptosis of oral epithelial cells and the further regulation in macrophage activation.
Geng F, Liu J, Yin C, Zhang S, Pan Y, Sun H
Journal of oral microbiology 2022;14(1):2041790
Journal of oral microbiology 2022;14(1):2041790
A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma.
Khan M, Lin J, Wang B, Chen C, Huang Z, Tian Y, Yuan Y, Bu J
Frontiers in immunology 2022;13:968165
Frontiers in immunology 2022;13:968165
Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease.
Wang X, Liu XQ, Jiang L, Huang YB, Zeng HX, Zhu QJ, Qi XM, Wu YG
Frontiers in pharmacology 2022;13:966645
Frontiers in pharmacology 2022;13:966645
New insights of necroptosis and immune infiltration in sepsis-induced myocardial dysfunction from bioinformatics analysis through RNA-seq in mice.
Du Y, Zhong Y, Ding R, Wang X, Xia F, Zhang Q, Peng Q
Frontiers in cellular and infection microbiology 2022;12:1068324
Frontiers in cellular and infection microbiology 2022;12:1068324
Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.
Sun S, Huan S, Li Z, Yao Y, Su Y, Xia S, Wang S, Xu X, Shao J, Zhang Z, Zhang F, Fu J, Zheng S
PeerJ 2022;10:e13376
PeerJ 2022;10:e13376
Mesenchymal Stem Cells-Derived Exosomes Ameliorate Ischemia/Reperfusion Induced Acute Kidney Injury in a Porcine Model.
Huang J, Cao H, Cui B, Ma X, Gao L, Yu C, Shen F, Yang X, Liu N, Qiu A, Cai G, Zhuang S
Frontiers in cell and developmental biology 2022;10:899869
Frontiers in cell and developmental biology 2022;10:899869
Protective effect of inhibiting necroptosis on gentamicin-induced nephrotoxicity.
Hu BF, Gong Q, Chen SQ, Yue L, Ma WX, Wang F, Feng XW, Wang JN, Li C, Liu MM, Wang XF, Meng XM, Li J, Wen JG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Sep;36(9):e22487
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Sep;36(9):e22487
Central nervous system stimulants promote nerve cell death under continuous hypoxia.
Ikeda-Murakami K, Ikeda T, Watanabe M, Tani N, Ishikawa T
Human cell 2022 Sep;35(5):1391-1407
Human cell 2022 Sep;35(5):1391-1407
Novel pharmacological inhibition of JMJD3 improves necrotizing enterocolitis by attenuating the inflammatory response and ameliorating intestinal injury.
Ma S, Xu L, Chen L, Sun X, Hu F, Gong Y, Yang R, Li J, Wang Q, Huang S, Zhou H, Wang J
Biochemical pharmacology 2022 Sep;203:115165
Biochemical pharmacology 2022 Sep;203:115165
Study of the synergistic effect of singlet oxygen with other plasma-generated ROS in fungi inactivation during water disinfection.
Xu H, Fang C, Shao C, Li L, Huang Q
The Science of the total environment 2022 Sep 10;838(Pt 4):156576
The Science of the total environment 2022 Sep 10;838(Pt 4):156576
Tea polyphenols alleviates acetochlor-induced apoptosis and necroptosis via ROS/MAPK/NF-κB signaling in Ctenopharyngodon idellus kidney cells.
Zhao X, Shi X, Liu Q, Li X
Aquatic toxicology (Amsterdam, Netherlands) 2022 May;246:106153
Aquatic toxicology (Amsterdam, Netherlands) 2022 May;246:106153
Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance.
Wang Y, Xiong J, Yuan Y, Peng C, Wu P, Wang Y, Lu J, Yin Y, Xu J, Chen S, Liu J
Obesity (Silver Spring, Md.) 2022 Mar;30(3):680-693
Obesity (Silver Spring, Md.) 2022 Mar;30(3):680-693
Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.
Sun S, Li Z, Huan S, Kai J, Xia S, Su Y, Ji S, Chen A, Wang S, Xu X, Shao J, Zhang F, Zhang B, Zhang Z, Zheng S
Phytotherapy research : PTR 2022 Jun;36(6):2660-2676
Phytotherapy research : PTR 2022 Jun;36(6):2660-2676
LRG-1 promotes fat graft survival through the RAB31-mediated inhibition of hypoxia-induced apoptosis.
Ho CK, Zheng D, Sun J, Wen D, Wu S, Yu L, Gao Y, Zhang Y, Li Q
Journal of cellular and molecular medicine 2022 Jun;26(11):3153-3168
Journal of cellular and molecular medicine 2022 Jun;26(11):3153-3168
Sperm-Associated Antigen 9 Promotes Influenza A Virus-Induced Cell Death via the c-Jun N-Terminal Kinase Signaling Pathway.
Gui R, Zheng H, Ma L, Liu R, Lin X, Ke X, Ye C, Jian X, Chen Q
mBio 2022 Jun 28;13(3):e0061522
mBio 2022 Jun 28;13(3):e0061522
LncRNA 122049 suppresses apoptosis of renal tubular epithelial cells in ischemic AKI by targeting the miR-330-5p/ELK1 axis.
Xiao Y, Li X, Qiu S, Wang Y, Zhang D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22395
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22395
Selenium Deficiency Induces Apoptosis and Necroptosis Through ROS/MAPK Signal in Human Uterine Smooth Muscle Cells.
Wang Y, Li X, Yao Y, Zhao X, Shi X, Cai Y
Biological trace element research 2022 Jul;200(7):3147-3158
Biological trace element research 2022 Jul;200(7):3147-3158
RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage.
Huang S, Hu W, Rao D, Wu X, Bai Q, Wang J, Chu Z, Xu Y
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2022 Jan;31(1):106213
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2022 Jan;31(1):106213
Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis.
Liu Q, Du P, Zhu Y, Zhang X, Cai J, Zhang Z
Cellular and molecular life sciences : CMLS 2022 Jan 30;79(2):106
Cellular and molecular life sciences : CMLS 2022 Jan 30;79(2):106
Protective Effect of MFG-E8 on Necroptosis-Induced Intestinal Inflammation and Enteroendocrine Cell Function in Diabetes.
Hua X, Li B, Yu F, Zhao W, Tan Y, Li X, Fu C, Yu X, Gao H, Cheng M
Nutrients 2022 Jan 29;14(3)
Nutrients 2022 Jan 29;14(3)
The role of KIAA1191 in the necroptotic pathway of multiple myeloma.
Xu Z, Sun Y, Jiang J, Liu P
Annals of hematology 2022 Feb;101(2):359-367
Annals of hematology 2022 Feb;101(2):359-367
Salmonella pSLT-encoded effector SpvB promotes RIPK3-dependent necroptosis in intestinal epithelial cells.
Dong K, Zhu Y, Deng Q, Sun L, Yang S, Huang K, Cao Y, Li Y, Wu S, Huang R
Cell death discovery 2022 Feb 2;8(1):44
Cell death discovery 2022 Feb 2;8(1):44
Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis.
Wang L, Yan H, Chen X, Lee J, Sun J, Liu G, Yang H, Lu D, Liu W, Che C
International immunopharmacology 2022 Dec;113(Pt A):109275
International immunopharmacology 2022 Dec;113(Pt A):109275
Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line.
Tu Y, Yang Y, Wang Y, Wu N, Tao J, Yang G, You M
Environmental pollution (Barking, Essex : 1987) 2022 Dec 1;314:120217
Environmental pollution (Barking, Essex : 1987) 2022 Dec 1;314:120217
Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification.
Feng W, Shi W, Wang Z, Cui Y, Shao X, Liu S, Rong L, Liu Y, Zhang H
ACS applied materials & interfaces 2022 Aug 24;14(33):37540-37552
ACS applied materials & interfaces 2022 Aug 24;14(33):37540-37552
Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.
Zhu J, Liu L, Ma J, Fu Q, Zheng Z, Du E, Xu Y, Zhang Z
Environmental pollution (Barking, Essex : 1987) 2022 Aug 1;306:119421
Environmental pollution (Barking, Essex : 1987) 2022 Aug 1;306:119421
Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis.
Yu C, Lei Z, Li X, Huang LH, Li ZQ, Zhu HW, Han D, Huang H, Yu X
Biochemical genetics 2022 Apr;60(2):598-610
Biochemical genetics 2022 Apr;60(2):598-610
Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19.
Bilinska K, von Bartheld CS, Butowt R
Frontiers in cellular neuroscience 2021;15:674123
Frontiers in cellular neuroscience 2021;15:674123
Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro.
Wang F, Tang L, Liang B, Jin C, Gao L, Li Y, Li Z, Shao J, Zhang Z, Tan S, Zhang F, Zheng S
Frontiers in pharmacology 2021;12:658811
Frontiers in pharmacology 2021;12:658811
RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus.
Wen C, Yu Y, Gao C, Qi X, Cardona CJ, Xing Z
Frontiers in cellular and infection microbiology 2021;11:637710
Frontiers in cellular and infection microbiology 2021;11:637710
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.
Zhu J, Xin M, Xu C, He Y, Zhang W, Wang Z, Zhuang C
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3193-3205
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3193-3205
ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency.
Cui M, Liu D, Xiong W, Wang Y, Mi J
Cell death discovery 2021 Oct 4;7(1):274
Cell death discovery 2021 Oct 4;7(1):274
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
Wang Y, Song M, Zhou P, Wang J, Zheng J, Xu H
International immunopharmacology 2021 Nov;100:108067
International immunopharmacology 2021 Nov;100:108067
Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice.
Li X, Cai Y, Luo J, Ding J, Yao G, Xiao X, Tang Y, Liang Z
Cell death discovery 2021 Nov 8;7(1):338
Cell death discovery 2021 Nov 8;7(1):338
Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway.
Zhang H, Zhou L, Zhou Y, Wang L, Jiang W, Liu L, Yue S, Zheng P, Liu H
Life sciences 2021 Nov 15;285:119963
Life sciences 2021 Nov 15;285:119963
Pterocephin A, a novel Triterpenoid Saponin from Pterocephalus hookeri induced liver injury by activation of necroptosis.
Wang R, Wei L, Dong Z, Meng F, Wang G, Zhou S, Lan X, Liao Z, Chen M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 May;85:153548
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 May;85:153548
Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer.
Long K, Gu L, Li L, Zhang Z, Li E, Zhang Y, He L, Pan F, Guo Z, Hu Z
Cell death & disease 2021 May 18;12(6):503
Cell death & disease 2021 May 18;12(6):503
Deficiency of NEAT1 prevented MPP(+)-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis.
Zhou S, Zhang D, Guo J, Chen Z, Chen Y, Zhang J
Brain research 2021 Jan 1;1750:147156
Brain research 2021 Jan 1;1750:147156
CB1R Promotes Chronic Alcohol-Induced Neuronal Necroptosis in Mice Prefrontal Cortex.
Ye L, Li S, Liu X, Zhang D, Li L, Jiang Y
Alcohol and alcoholism (Oxford, Oxfordshire) 2021 Feb 24;56(2):230-239
Alcohol and alcoholism (Oxford, Oxfordshire) 2021 Feb 24;56(2):230-239
The Performance of HepG2 and HepaRG Systems through the Glass of Acetaminophen-Induced Toxicity.
Lőrincz T, Deák V, Makk-Merczel K, Varga D, Hajdinák P, Szarka A
Life (Basel, Switzerland) 2021 Aug 21;11(8)
Life (Basel, Switzerland) 2021 Aug 21;11(8)
Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation.
Wu F, Shao Q, Cheng Z, Xiong X, Fang K, Zhao Y, Dong R, Xu L, Lu F, Chen G
Chinese medicine 2021 Aug 16;16(1):78
Chinese medicine 2021 Aug 16;16(1):78
Cadmium exposure induces TNF-α-mediated necroptosis via FPR2/TGF-β/NF-κB pathway in swine myocardium.
Zhao X, Wang S, Li X, Liu H, Xu S
Toxicology 2021 Apr 15;453:152733
Toxicology 2021 Apr 15;453:152733
M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.
Zhou XL, Yang J, Qu XJ, Meng J, Miao RR, Cui SX
Frontiers in pharmacology 2020;11:557312
Frontiers in pharmacology 2020;11:557312
Coxsackievirus A6 Induces Necroptosis for Viral Production.
Zhang S, Yu X, Meng X, Huo W, Su Y, Liu J, Liu Y, Zhang J, Wang S, Yu J
Frontiers in microbiology 2020;11:42
Frontiers in microbiology 2020;11:42
Combination of Rapamycin and MK-2206 Induced Cell Death via Autophagy and Necroptosis in MYCN-Amplified Neuroblastoma Cell Lines.
Dong Y, Gong W, Hua Z, Chen B, Zhao G, Liu Z, Thiele CJ, Li Z
Frontiers in pharmacology 2020;11:31
Frontiers in pharmacology 2020;11:31
Cryptotanshinone protects dextran sulfate sodium-induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation.
Min X, Zeng X, Zhao W, Han Z, Wang Y, Han Y, Pei L, Chen X
Phytotherapy research : PTR 2020 Oct;34(10):2639-2648
Phytotherapy research : PTR 2020 Oct;34(10):2639-2648
Pharmacological activation of CB2 receptor protects against ethanol-induced myocardial injury related to RIP1/RIP3/MLKL-mediated necroptosis.
Liu X, Zhang D, Dong X, Zhu R, Ye Y, Li L, Jiang Y
Molecular and cellular biochemistry 2020 Nov;474(1-2):1-14
Molecular and cellular biochemistry 2020 Nov;474(1-2):1-14
Protective effect of astaxanthin against SnS(2) nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
Yuan L, Liang P, Qu Y, An T, Wang J, Deng X, Bai L, Shen P, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
Necroptosis mediated by impaired autophagy flux contributes to adverse ventricular remodeling after myocardial infarction.
Zhang H, Yin Y, Liu Y, Zou G, Huang H, Qian P, Zhang G, Zhang J
Biochemical pharmacology 2020 May;175:113915
Biochemical pharmacology 2020 May;175:113915
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Lin Y, Yu M, Fan T
Toxicology letters 2020 Mar 1;320:9-18
Toxicology letters 2020 Mar 1;320:9-18
Raman micro-spectroscopy monitoring of cytochrome c redox state in Candida utilis during cell death under low-temperature plasma-induced oxidative stress.
Chen Z, Liu J, Tian L, Zhang Q, Guan Y, Chen L, Liu G, Yu HQ, Tian Y, Huang Q
The Analyst 2020 Jun 7;145(11):3922-3930
The Analyst 2020 Jun 7;145(11):3922-3930
SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States.
Wu K, Liu H, Wang Y, He J, Xu S, Chen Y, Kuang J, Liu J, Guo L, Li D, Shi R, Shen L, Wang Y, Zhang X, Wang J, Pei D, Chen J
Cell reports 2020 Jan 7;30(1):25-36.e6
Cell reports 2020 Jan 7;30(1):25-36.e6
Protective effect of dabrafenib on renal ischemia-reperfusion injury in vivo and in vitro.
Liu SS, Chen YY, Wang SX, Yu Q
Biochemical and biophysical research communications 2020 Feb 5;522(2):395-401
Biochemical and biophysical research communications 2020 Feb 5;522(2):395-401
Necrostatin-1 Alleviates Bleomycin-Induced Pulmonary Fibrosis and Extracellular Matrix Expression in Interstitial Pulmonary Fibrosis.
Mou F, Mou C
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 5;26:e919739
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 5;26:e919739
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
Zhang X, Wu J, Liu Q, Li X, Li S, Chen J, Hong Z, Wu X, Zhao Y, Ren J
Cell death & disease 2020 Dec 11;11(12):1050
Cell death & disease 2020 Dec 11;11(12):1050
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Yang T, Fan TJ, Xu B
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.
Guo FX, Wu Q, Li P, Zheng L, Ye S, Dai XY, Kang CM, Lu JB, Xu BM, Xu YJ, Xiao L, Lu ZF, Bai HL, Hu YW, Wang Q
Cell death and differentiation 2019 Sep;26(9):1670-1687
Cell death and differentiation 2019 Sep;26(9):1670-1687
MUC1 downregulation promotes TNF-α-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway.
Zhang H, Ji J, Liu Q, Xu S
Journal of cellular physiology 2019 Sep;234(9):15080-15088
Journal of cellular physiology 2019 Sep;234(9):15080-15088
Necrostatin-1 Attenuates Renal Ischemia and Reperfusion Injury via Meditation of HIF-1α/mir-26a/TRPC6/PARP1 Signaling.
Shen B, Mei M, Pu Y, Zhang H, Liu H, Tang M, Pan Q, He Y, Wu X, Zhao H
Molecular therapy. Nucleic acids 2019 Sep 6;17:701-713
Molecular therapy. Nucleic acids 2019 Sep 6;17:701-713
Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
Li X, Peng Z, Zhou Y, Wang J, Lin X, Dong X, Liu X, Jiang J, Jiang Y, Li L
Toxicology letters 2019 Oct 1;313:77-90
Toxicology letters 2019 Oct 1;313:77-90
PEDF decreases cardiomyocyte edema during oxygen‑glucose deprivation and recovery via inhibiting lactate accumulation and expression of AQP1.
Huang B, Miao H, Yuan Y, Qiu F, Liu X, Liu Z, Zhang H, Zhao Q, Wang M, Dong H, Zhang Z
International journal of molecular medicine 2019 May;43(5):1979-1990
International journal of molecular medicine 2019 May;43(5):1979-1990
Evaluation of the Liver Toxicity of Pterocephalus hookeri Extract via Triggering Necrosis.
Wang R, Dong Z, Zhang X, Mao J, Meng F, Lan X, Liao Z, Chen M
Toxins 2019 Mar 2;11(3)
Toxins 2019 Mar 2;11(3)
A "Hibernating-Like" Viable State Induced by Lentiviral Vector-Mediated Pigment Epithelium-Derived Factor Overexpression in Rat Acute Ischemic Myocardium.
Yuan Y, Huang B, Miao H, Liu X, Zhang H, Qiu F, Liu Z, Zhang Y, Dong H, Zhang Z
Human gene therapy 2019 Jun;30(6):762-776
Human gene therapy 2019 Jun;30(6):762-776
Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation.
Chen J, Jiang Z, Zhou X, Sun X, Cao J, Liu Y, Wang X
Cardiovascular drugs and therapy 2019 Feb;33(1):45-54
Cardiovascular drugs and therapy 2019 Feb;33(1):45-54
Necroptosis and Apoptosis Contribute to Cisplatin and Aminoglycoside Ototoxicity.
Ruhl D, Du TT, Wagner EL, Choi JH, Li S, Reed R, Kim K, Freeman M, Hashisaki G, Lukens JR, Shin JB
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Apr 10;39(15):2951-2964
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Apr 10;39(15):2951-2964
Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis.
Wu X, Guo Y, Min X, Pei L, Chen X
The American journal of Chinese medicine 2018;46(6):1263-1279
The American journal of Chinese medicine 2018;46(6):1263-1279
Selenoprotein S silencing triggers mouse hepatoma cells apoptosis and necrosis involving in intracellular calcium imbalance and ROS-mPTP-ATP.
Li X, Chen M, Yang Z, Wang W, Lin H, Xu S
Biochimica et biophysica acta. General subjects 2018 Oct;1862(10):2113-2123
Biochimica et biophysica acta. General subjects 2018 Oct;1862(10):2113-2123
Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis.
Hu J, Wang H, Gu J, Liu X, Zhou X
Acta biochimica et biophysica Sinica 2018 Oct 1;50(10):1018-1027
Acta biochimica et biophysica Sinica 2018 Oct 1;50(10):1018-1027
Receptor-Interacting Protein 3/Caspase-8 May Regulate Inflammatory Response and Promote Tissue Regeneration in the Periodontal Microenvironment.
Yan B, Wei K, Hou L, Dai T, Gu Y, Qiu X, Chen J, Feng Y, Cheng H, Yu Z, Zhang Y, Zhang H, Li D
Medical science monitor : international medical journal of experimental and clinical research 2018 Jul 29;24:5247-5257
Medical science monitor : international medical journal of experimental and clinical research 2018 Jul 29;24:5247-5257
TNF-α increases Staphylococcus aureus-induced death of human alveolar epithelial cell line A549 associated with RIP3-mediated necroptosis.
Wen SH, Lin LN, Wu HJ, Yu L, Lin L, Zhu LL, Li HY, Zhang HL, Li CC
Life sciences 2018 Feb 15;195:81-86
Life sciences 2018 Feb 15;195:81-86
Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice.
Guo Y, Wu X, Wu Q, Lu Y, Shi J, Chen X
Toxicology and applied pharmacology 2018 Apr 1;344:35-45
Toxicology and applied pharmacology 2018 Apr 1;344:35-45
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 17563-1-AP(RIPK3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RIP3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RIP3. This antibody recognizes human, mouse antigen. The RIP3 antibody has been validated for the following applications: ELISA, WB, IP analysis.
