Antibody data
- Antibody Data
- Antigen structure
- References [46]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
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Validation data
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- Product number
- 17563-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17563-1-AP, RRID:AB_2178659
- Product name
- RIP3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RIP3 antibody (Cat. #17563-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro.
RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus.
Selenium Deficiency Induces Apoptosis and Necroptosis Through ROS/MAPK Signal in Human Uterine Smooth Muscle Cells.
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.
ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency.
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice.
RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage.
Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway.
Pterocephin A, a novel Triterpenoid Saponin from Pterocephalus hookeri induced liver injury by activation of necroptosis.
Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer.
Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis.
Deficiency of NEAT1 prevented MPP+-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis.
CB1R Promotes Chronic Alcohol-Induced Neuronal Necroptosis in Mice Prefrontal Cortex.
The Performance of HepG2 and HepaRG Systems through the Glass of Acetaminophen-Induced Toxicity.
Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation.
Cadmium exposure induces TNF-α-mediated necroptosis via FPR2/TGF-β/NF-κB pathway in swine myocardium.
M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.
Coxsackievirus A6 Induces Necroptosis for Viral Production.
Combination of Rapamycin and MK-2206 Induced Cell Death via Autophagy and Necroptosis in MYCN-Amplified Neuroblastoma Cell Lines.
Cryptotanshinone protects dextran sulfate sodium-induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation.
Pharmacological activation of CB2 receptor protects against ethanol-induced myocardial injury related to RIP1/RIP3/MLKL-mediated necroptosis.
Protective effect of astaxanthin against SnS2 nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
Necroptosis mediated by impaired autophagy flux contributes to adverse ventricular remodeling after myocardial infarction.
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Raman micro-spectroscopy monitoring of cytochrome c redox state in Candida utilis during cell death under low-temperature plasma-induced oxidative stress.
SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States.
Protective effect of dabrafenib on renal ischemia-reperfusion injury in vivo and in vitro.
Necrostatin-1 Alleviates Bleomycin-Induced Pulmonary Fibrosis and Extracellular Matrix Expression in Interstitial Pulmonary Fibrosis.
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.
Necrostatin-1 Attenuates Renal Ischemia and Reperfusion Injury via Meditation of HIF-1α/mir-26a/TRPC6/PARP1 Signaling.
Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
PEDF decreases cardiomyocyte edema during oxygen‑glucose deprivation and recovery via inhibiting lactate accumulation and expression of AQP1.
Evaluation of the Liver Toxicity of Pterocephalus hookeri Extract via Triggering Necrosis.
A "Hibernating-Like" Viable State Induced by Lentiviral Vector-Mediated Pigment Epithelium-Derived Factor Overexpression in Rat Acute Ischemic Myocardium.
MUC1 downregulation promotes TNF-α-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway.
Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation.
Necroptosis and Apoptosis Contribute to Cisplatin and Aminoglycoside Ototoxicity.
Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis.
Selenoprotein S silencing triggers mouse hepatoma cells apoptosis and necrosis involving in intracellular calcium imbalance and ROS-mPTP-ATP.
Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis.
Receptor-Interacting Protein 3/Caspase-8 May Regulate Inflammatory Response and Promote Tissue Regeneration in the Periodontal Microenvironment.
TNF-α increases Staphylococcus aureus-induced death of human alveolar epithelial cell line A549 associated with RIP3-mediated necroptosis.
Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice.
Wang F, Tang L, Liang B, Jin C, Gao L, Li Y, Li Z, Shao J, Zhang Z, Tan S, Zhang F, Zheng S
Frontiers in pharmacology 2021;12:658811
Frontiers in pharmacology 2021;12:658811
RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus.
Wen C, Yu Y, Gao C, Qi X, Cardona CJ, Xing Z
Frontiers in cellular and infection microbiology 2021;11:637710
Frontiers in cellular and infection microbiology 2021;11:637710
Selenium Deficiency Induces Apoptosis and Necroptosis Through ROS/MAPK Signal in Human Uterine Smooth Muscle Cells.
Wang Y, Li X, Yao Y, Zhao X, Shi X, Cai Y
Biological trace element research 2021 Sep 4;
Biological trace element research 2021 Sep 4;
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.
Zhu J, Xin M, Xu C, He Y, Zhang W, Wang Z, Zhuang C
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3193-3205
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3193-3205
ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency.
Cui M, Liu D, Xiong W, Wang Y, Mi J
Cell death discovery 2021 Oct 4;7(1):274
Cell death discovery 2021 Oct 4;7(1):274
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
Wang Y, Song M, Zhou P, Wang J, Zheng J, Xu H
International immunopharmacology 2021 Nov;100:108067
International immunopharmacology 2021 Nov;100:108067
Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice.
Li X, Cai Y, Luo J, Ding J, Yao G, Xiao X, Tang Y, Liang Z
Cell death discovery 2021 Nov 8;7(1):338
Cell death discovery 2021 Nov 8;7(1):338
RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage.
Huang S, Hu W, Rao D, Wu X, Bai Q, Wang J, Chu Z, Xu Y
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2021 Nov 24;31(1):106213
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2021 Nov 24;31(1):106213
Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway.
Zhang H, Zhou L, Zhou Y, Wang L, Jiang W, Liu L, Yue S, Zheng P, Liu H
Life sciences 2021 Nov 15;285:119963
Life sciences 2021 Nov 15;285:119963
Pterocephin A, a novel Triterpenoid Saponin from Pterocephalus hookeri induced liver injury by activation of necroptosis.
Wang R, Wei L, Dong Z, Meng F, Wang G, Zhou S, Lan X, Liao Z, Chen M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 May;85:153548
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 May;85:153548
Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer.
Long K, Gu L, Li L, Zhang Z, Li E, Zhang Y, He L, Pan F, Guo Z, Hu Z
Cell death & disease 2021 May 18;12(6):503
Cell death & disease 2021 May 18;12(6):503
Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis.
Yu C, Lei Z, Li X, Huang LH, Li ZQ, Zhu HW, Han D, Huang H, Yu X
Biochemical genetics 2021 Jul 29;
Biochemical genetics 2021 Jul 29;
Deficiency of NEAT1 prevented MPP+-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis.
Zhou S, Zhang D, Guo J, Chen Z, Chen Y, Zhang J
Brain research 2021 Jan 1;1750:147156
Brain research 2021 Jan 1;1750:147156
CB1R Promotes Chronic Alcohol-Induced Neuronal Necroptosis in Mice Prefrontal Cortex.
Ye L, Li S, Liu X, Zhang D, Li L, Jiang Y
Alcohol and alcoholism (Oxford, Oxfordshire) 2021 Feb 24;56(2):230-239
Alcohol and alcoholism (Oxford, Oxfordshire) 2021 Feb 24;56(2):230-239
The Performance of HepG2 and HepaRG Systems through the Glass of Acetaminophen-Induced Toxicity.
Lőrincz T, Deák V, Makk-Merczel K, Varga D, Hajdinák P, Szarka A
Life (Basel, Switzerland) 2021 Aug 21;11(8)
Life (Basel, Switzerland) 2021 Aug 21;11(8)
Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation.
Wu F, Shao Q, Cheng Z, Xiong X, Fang K, Zhao Y, Dong R, Xu L, Lu F, Chen G
Chinese medicine 2021 Aug 16;16(1):78
Chinese medicine 2021 Aug 16;16(1):78
Cadmium exposure induces TNF-α-mediated necroptosis via FPR2/TGF-β/NF-κB pathway in swine myocardium.
Zhao X, Wang S, Li X, Liu H, Xu S
Toxicology 2021 Apr 15;453:152733
Toxicology 2021 Apr 15;453:152733
M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.
Zhou XL, Yang J, Qu XJ, Meng J, Miao RR, Cui SX
Frontiers in pharmacology 2020;11:557312
Frontiers in pharmacology 2020;11:557312
Coxsackievirus A6 Induces Necroptosis for Viral Production.
Zhang S, Yu X, Meng X, Huo W, Su Y, Liu J, Liu Y, Zhang J, Wang S, Yu J
Frontiers in microbiology 2020;11:42
Frontiers in microbiology 2020;11:42
Combination of Rapamycin and MK-2206 Induced Cell Death via Autophagy and Necroptosis in MYCN-Amplified Neuroblastoma Cell Lines.
Dong Y, Gong W, Hua Z, Chen B, Zhao G, Liu Z, Thiele CJ, Li Z
Frontiers in pharmacology 2020;11:31
Frontiers in pharmacology 2020;11:31
Cryptotanshinone protects dextran sulfate sodium-induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation.
Min X, Zeng X, Zhao W, Han Z, Wang Y, Han Y, Pei L, Chen X
Phytotherapy research : PTR 2020 Oct;34(10):2639-2648
Phytotherapy research : PTR 2020 Oct;34(10):2639-2648
Pharmacological activation of CB2 receptor protects against ethanol-induced myocardial injury related to RIP1/RIP3/MLKL-mediated necroptosis.
Liu X, Zhang D, Dong X, Zhu R, Ye Y, Li L, Jiang Y
Molecular and cellular biochemistry 2020 Nov;474(1-2):1-14
Molecular and cellular biochemistry 2020 Nov;474(1-2):1-14
Protective effect of astaxanthin against SnS2 nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
Yuan L, Liang P, Qu Y, An T, Wang J, Deng X, Bai L, Shen P, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
Necroptosis mediated by impaired autophagy flux contributes to adverse ventricular remodeling after myocardial infarction.
Zhang H, Yin Y, Liu Y, Zou G, Huang H, Qian P, Zhang G, Zhang J
Biochemical pharmacology 2020 May;175:113915
Biochemical pharmacology 2020 May;175:113915
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Lin Y, Yu M, Fan T
Toxicology letters 2020 Mar 1;320:9-18
Toxicology letters 2020 Mar 1;320:9-18
Raman micro-spectroscopy monitoring of cytochrome c redox state in Candida utilis during cell death under low-temperature plasma-induced oxidative stress.
Chen Z, Liu J, Tian L, Zhang Q, Guan Y, Chen L, Liu G, Yu HQ, Tian Y, Huang Q
The Analyst 2020 Jun 7;145(11):3922-3930
The Analyst 2020 Jun 7;145(11):3922-3930
SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States.
Wu K, Liu H, Wang Y, He J, Xu S, Chen Y, Kuang J, Liu J, Guo L, Li D, Shi R, Shen L, Wang Y, Zhang X, Wang J, Pei D, Chen J
Cell reports 2020 Jan 7;30(1):25-36.e6
Cell reports 2020 Jan 7;30(1):25-36.e6
Protective effect of dabrafenib on renal ischemia-reperfusion injury in vivo and in vitro.
Liu SS, Chen YY, Wang SX, Yu Q
Biochemical and biophysical research communications 2020 Feb 5;522(2):395-401
Biochemical and biophysical research communications 2020 Feb 5;522(2):395-401
Necrostatin-1 Alleviates Bleomycin-Induced Pulmonary Fibrosis and Extracellular Matrix Expression in Interstitial Pulmonary Fibrosis.
Mou F, Mou C
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 5;26:e919739
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 5;26:e919739
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
Zhang X, Wu J, Liu Q, Li X, Li S, Chen J, Hong Z, Wu X, Zhao Y, Ren J
Cell death & disease 2020 Dec 11;11(12):1050
Cell death & disease 2020 Dec 11;11(12):1050
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Yang T, Fan TJ, Xu B
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.
Guo FX, Wu Q, Li P, Zheng L, Ye S, Dai XY, Kang CM, Lu JB, Xu BM, Xu YJ, Xiao L, Lu ZF, Bai HL, Hu YW, Wang Q
Cell death and differentiation 2019 Sep;26(9):1670-1687
Cell death and differentiation 2019 Sep;26(9):1670-1687
Necrostatin-1 Attenuates Renal Ischemia and Reperfusion Injury via Meditation of HIF-1α/mir-26a/TRPC6/PARP1 Signaling.
Shen B, Mei M, Pu Y, Zhang H, Liu H, Tang M, Pan Q, He Y, Wu X, Zhao H
Molecular therapy. Nucleic acids 2019 Sep 6;17:701-713
Molecular therapy. Nucleic acids 2019 Sep 6;17:701-713
Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
Li X, Peng Z, Zhou Y, Wang J, Lin X, Dong X, Liu X, Jiang J, Jiang Y, Li L
Toxicology letters 2019 Oct 1;313:77-90
Toxicology letters 2019 Oct 1;313:77-90
PEDF decreases cardiomyocyte edema during oxygen‑glucose deprivation and recovery via inhibiting lactate accumulation and expression of AQP1.
Huang B, Miao H, Yuan Y, Qiu F, Liu X, Liu Z, Zhang H, Zhao Q, Wang M, Dong H, Zhang Z
International journal of molecular medicine 2019 May;43(5):1979-1990
International journal of molecular medicine 2019 May;43(5):1979-1990
Evaluation of the Liver Toxicity of Pterocephalus hookeri Extract via Triggering Necrosis.
Wang R, Dong Z, Zhang X, Mao J, Meng F, Lan X, Liao Z, Chen M
Toxins 2019 Mar 2;11(3)
Toxins 2019 Mar 2;11(3)
A "Hibernating-Like" Viable State Induced by Lentiviral Vector-Mediated Pigment Epithelium-Derived Factor Overexpression in Rat Acute Ischemic Myocardium.
Yuan Y, Huang B, Miao H, Liu X, Zhang H, Qiu F, Liu Z, Zhang Y, Dong H, Zhang Z
Human gene therapy 2019 Jun;30(6):762-776
Human gene therapy 2019 Jun;30(6):762-776
MUC1 downregulation promotes TNF-α-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway.
Zhang H, Ji J, Liu Q, Xu S
Journal of cellular physiology 2019 Jan 21;
Journal of cellular physiology 2019 Jan 21;
Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation.
Chen J, Jiang Z, Zhou X, Sun X, Cao J, Liu Y, Wang X
Cardiovascular drugs and therapy 2019 Feb;33(1):45-54
Cardiovascular drugs and therapy 2019 Feb;33(1):45-54
Necroptosis and Apoptosis Contribute to Cisplatin and Aminoglycoside Ototoxicity.
Ruhl D, Du TT, Wagner EL, Choi JH, Li S, Reed R, Kim K, Freeman M, Hashisaki G, Lukens JR, Shin JB
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Apr 10;39(15):2951-2964
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Apr 10;39(15):2951-2964
Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis.
Wu X, Guo Y, Min X, Pei L, Chen X
The American journal of Chinese medicine 2018;46(6):1263-1279
The American journal of Chinese medicine 2018;46(6):1263-1279
Selenoprotein S silencing triggers mouse hepatoma cells apoptosis and necrosis involving in intracellular calcium imbalance and ROS-mPTP-ATP.
Li X, Chen M, Yang Z, Wang W, Lin H, Xu S
Biochimica et biophysica acta. General subjects 2018 Oct;1862(10):2113-2123
Biochimica et biophysica acta. General subjects 2018 Oct;1862(10):2113-2123
Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis.
Hu J, Wang H, Gu J, Liu X, Zhou X
Acta biochimica et biophysica Sinica 2018 Oct 1;50(10):1018-1027
Acta biochimica et biophysica Sinica 2018 Oct 1;50(10):1018-1027
Receptor-Interacting Protein 3/Caspase-8 May Regulate Inflammatory Response and Promote Tissue Regeneration in the Periodontal Microenvironment.
Yan B, Wei K, Hou L, Dai T, Gu Y, Qiu X, Chen J, Feng Y, Cheng H, Yu Z, Zhang Y, Zhang H, Li D
Medical science monitor : international medical journal of experimental and clinical research 2018 Jul 29;24:5247-5257
Medical science monitor : international medical journal of experimental and clinical research 2018 Jul 29;24:5247-5257
TNF-α increases Staphylococcus aureus-induced death of human alveolar epithelial cell line A549 associated with RIP3-mediated necroptosis.
Wen SH, Lin LN, Wu HJ, Yu L, Lin L, Zhu LL, Li HY, Zhang HL, Li CC
Life sciences 2018 Feb 15;195:81-86
Life sciences 2018 Feb 15;195:81-86
Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice.
Guo Y, Wu X, Wu Q, Lu Y, Shi J, Chen X
Toxicology and applied pharmacology 2018 Apr 1;344:35-45
Toxicology and applied pharmacology 2018 Apr 1;344:35-45
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 17563-1-AP(RIPK3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RIP3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RIP3. This antibody recognizes human, mouse antigen. The RIP3 antibody has been validated for the following applications: ELISA, WB, IP analysis.