Antibody data
- Antibody Data
- Antigen structure
- References [80]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 12570-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12570-1-AP, RRID:AB_2193037
- Product name
- SMAD2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SMAD2 antibody (Cat. #12570-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Elevated IgE promotes cardiac fibrosis by suppressing miR-486a-5p.
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro.
Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling.
Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway.
The miR-182/Myadm axis regulates hypoxia-induced pulmonary hypertension by balancing the BMP- and TGF-β-signalling pathways in an SMC/EC-crosstalk-associated manner.
Bergenin attenuates bleomycin-induced pulmonary fibrosis in mice via inhibiting TGF-β1 signaling pathway.
SMAD2 regulates testicular development and testosterone synthesis in Hu sheep.
Protection of CAPE-pNO2 Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Adiponectin Alleviates Intestinal Fibrosis by Enhancing AMP-Activated Protein Kinase Phosphorylation.
Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway.
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-β1/Smad pathway.
Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells (HSCs) in vitro and CCl4-induced hepatic fibrosis in rats in vivo.
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.
PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis.
SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion.
Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions.
MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein.
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2.
Ligand-independent EphB1 signaling mediates TGF-β-activated CDH2 and promotes lung cancer cell invasion and migration.
Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway.
KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway.
Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing.
TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis.
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma.
Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-β signals.
Raw and vinegar processed Curcuma wenyujin regulates hepatic fibrosis via bloking TGF-β/Smad signaling pathways and up-regulation of MMP-2/TIMP-1 ratio.
Retinal pigment epithelial cells secrete miR-202-5p-containing exosomes to protect against proliferative diabetic retinopathy.
miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling.
LncRNA Gm16410 regulates PM2.5-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway.
MicroRNA-148a-3p inhibits progression of hepatocelluar carcimoma by repressing SMAD2 expression in an Ago2 dependent manner.
Inhibitory Effect of Corilagin on miR-21-Regulated Hepatic Fibrosis Signaling Pathway.
A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway.
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.
MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer.
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Platelets promote invasion and induce epithelial to mesenchymal transition in ovarian cancer cells by TGF-β signaling pathway.
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways.
LRG1 Promotes Apoptosis and Autophagy through the TGFβ-smad1/5 Signaling Pathway to Exacerbate Ischemia/Reperfusion Injury.
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma.
Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway.
Role of TGF-β1/Smad3-mediated fibrosis in drug resistance mechanism of prolactinoma.
MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.
PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.
Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway.
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.
Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization.
Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients.
High doses of baicalin induces kidney injury and fibrosis through regulating TGF-β/Smad signaling pathway.
Transforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling.
Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop.
Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer.
Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.
CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy.
Metformin alleviates vascular calcification induced by vitamin D3 plus nicotine in rats via the AMPK pathway.
In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse.
Phenylethanol Glycosides from Cistanche tubulosa Suppress Hepatic Stellate Cell Activation and Block the Conduction of Signaling Pathways in TGF-β1/smad as Potential Anti-Hepatic Fibrosis Agents.
Interplay between intergrin-linked kinase and ribonuclease inhibitor affects growth and metastasis of bladder cancer through signaling ILK pathways.
Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice.
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Potent effects of dioscin against liver fibrosis.
Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy.
TGF-β2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF.
The role of SIRT6 in the differentiation of vascular smooth muscle cells in response to cyclic strain.
Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice.
Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis.
Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease.
Zhang Z, Chen B, Zhu Y, Zhang T, Zhang X, Yuan Y, Xu Y
Frontiers in cell and developmental biology 2021;9:664375
Frontiers in cell and developmental biology 2021;9:664375
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Pan J, Cao Z, Fang C, Lei Y, Sun J, Huang X, Han D
Frontiers in pharmacology 2021;12:722530
Frontiers in pharmacology 2021;12:722530
Elevated IgE promotes cardiac fibrosis by suppressing miR-486a-5p.
Zhao H, Yang H, Geng C, Chen Y, Tang Y, Li Z, Pang J, Shu T, Nie Y, Liu Y, Jia K, Wang J
Theranostics 2021;11(15):7600-7615
Theranostics 2021;11(15):7600-7615
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Ni K, Huang Z, Zhu Y, Xue D, Jin Q, Zhang C, Gu C
Frontiers in oncology 2021;11:654472
Frontiers in oncology 2021;11:654472
Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro.
Lv W, Ren Y, Wu M, Luo X, Yu J, Zhang Q, Wu Y
Burns : journal of the International Society for Burn Injuries 2021 Sep;47(6):1359-1372
Burns : journal of the International Society for Burn Injuries 2021 Sep;47(6):1359-1372
Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling.
Zhao W, Zhang X, Hou M, Zhang Y, Tang Y, Li L, Dong S, Liu L, Zhao D, Li W, Nan Y
Histology and histopathology 2021 Sep;36(9):967-979
Histology and histopathology 2021 Sep;36(9):967-979
Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway.
Li S, Gan L, Tian YJ, Tian Y, Fan RZ, Huang D, Yuan FY, Zhang X, Lin Y, Zhu QF, Tang GH, Yan XL, Yin S
Bioorganic chemistry 2021 Sep;114:105222
Bioorganic chemistry 2021 Sep;114:105222
The miR-182/Myadm axis regulates hypoxia-induced pulmonary hypertension by balancing the BMP- and TGF-β-signalling pathways in an SMC/EC-crosstalk-associated manner.
Bai Y, Wang J, Chen Y, Lv T, Wang X, Liu C, Xue H, He K, Sun L
Basic research in cardiology 2021 Sep 21;116(1):53
Basic research in cardiology 2021 Sep 21;116(1):53
Bergenin attenuates bleomycin-induced pulmonary fibrosis in mice via inhibiting TGF-β1 signaling pathway.
Li X, Wang Y, Liang J, Bi Z, Ruan H, Cui Y, Ma L, Wei Y, Zhou B, Zhang L, Zhou H, Yang C
Phytotherapy research : PTR 2021 Oct;35(10):5808-5822
Phytotherapy research : PTR 2021 Oct;35(10):5808-5822
SMAD2 regulates testicular development and testosterone synthesis in Hu sheep.
Yang H, Wan Z, Jin Y, Wang F, Zhang Y
Theriogenology 2021 Oct 15;174:139-148
Theriogenology 2021 Oct 15;174:139-148
Protection of CAPE-pNO2 Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Wan Q, Zhang L, Zhou Q, Han Y, Li Z, Li B
Inflammation 2021 Nov 24;
Inflammation 2021 Nov 24;
Adiponectin Alleviates Intestinal Fibrosis by Enhancing AMP-Activated Protein Kinase Phosphorylation.
Xie M, Xiong Z, Yin S, Xiong J, Li X, Jin L, Zhang F, Chen H, Lan P, Lian L
Digestive diseases and sciences 2021 May 19;
Digestive diseases and sciences 2021 May 19;
Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway.
Xiao Y, Deng J, Li C, Gong X, Gui Z, Huang J, Zhang Y, Liu Y, Ye X, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153488
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153488
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Zhao B, Li S, Guo Z, Chen Z, Zhang X, Xu C, Chen J, Wei C
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-β1/Smad pathway.
Zheng M, Li H, Sun L, Brigstock DR, Gao R
Cytokine 2021 Jul;143:155536
Cytokine 2021 Jul;143:155536
Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells (HSCs) in vitro and CCl4-induced hepatic fibrosis in rats in vivo.
Wang R, Zhang D, Tang D, Sun K, Peng J, Zhu W, Yin S, Wu Y
International immunopharmacology 2021 Jan;90:107151
International immunopharmacology 2021 Jan;90:107151
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
Wang R, Wu G, Dai T, Lang Y, Chi Z, Yang S, Dong D
Experimental and therapeutic medicine 2021 Jan;21(1):66
Experimental and therapeutic medicine 2021 Jan;21(1):66
ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.
Ma L, Li C, Lian S, Xu B, Yuan J, Lu J, Yang H, Guo J, Ji H
Molecular and cellular endocrinology 2021 Jan 1;519:111055
Molecular and cellular endocrinology 2021 Jan 1;519:111055
PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis.
Yu Q, Cheng P, Wu J, Guo C
Journal of cellular and molecular medicine 2021 Feb;25(3):1645-1660
Journal of cellular and molecular medicine 2021 Feb;25(3):1645-1660
SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion.
Yang S, Zhang H, Yang H, Zhang J, Wang J, Luo T, Jiang Y, Hua H
Experimental hematology & oncology 2021 Feb 23;10(1):17
Experimental hematology & oncology 2021 Feb 23;10(1):17
Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions.
Chen X, Zhang Y, Qian W, Han L, Li W, Duan W, Wu Z, Wang Z, Ma Q
iScience 2021 Dec 17;24(12):103400
iScience 2021 Dec 17;24(12):103400
MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein.
Zhuang Y, Li X, Zhan P, Pi G, Wen G
Oncology reports 2021 Apr;45(4)
Oncology reports 2021 Apr;45(4)
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Xiao Y, Liu Y, Lai Z, Huang J, Li C, Zhang Y, Gong X, Deng J, Ye X, Li X
Journal of ethnopharmacology 2021 Apr 24;270:113806
Journal of ethnopharmacology 2021 Apr 24;270:113806
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, Chi T, Zou L, Wang S, He Z
Oxidative medicine and cellular longevity 2020;2020:7950457
Oxidative medicine and cellular longevity 2020;2020:7950457
USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2.
Dou N, Hu Q, Li L, Wu Q, Li Y, Gao Y
International journal of biological sciences 2020;16(9):1648-1657
International journal of biological sciences 2020;16(9):1648-1657
Ligand-independent EphB1 signaling mediates TGF-β-activated CDH2 and promotes lung cancer cell invasion and migration.
Wang L, Peng Q, Sai B, Zheng L, Xu J, Yin N, Feng X, Xiang J
Journal of Cancer 2020;11(14):4123-4131
Journal of Cancer 2020;11(14):4123-4131
Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway.
Li X, Leng Y, Jiang Q, Wang Z, Luo P, Zhang C, Chen L, Wang Y, Wang H, Yue X, Shen C, Zhou Y, Shi C, Xie L
Frontiers in pharmacology 2020;11:1038
Frontiers in pharmacology 2020;11:1038
KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway.
Li Y, Yang J, Zhang X, Liu H, Guo J
Experimental and therapeutic medicine 2020 Sep;20(3):2774-2782
Experimental and therapeutic medicine 2020 Sep;20(3):2774-2782
Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing.
Jiang L, Zhang Y, Liu T, Wang X, Wang H, Song H, Wang W
Biochimie 2020 Oct;177:40-49
Biochimie 2020 Oct;177:40-49
TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis.
Xu S, Mao Y, Wu J, Feng J, Li J, Wu L, Yu Q, Zhou Y, Zhang J, Chen J, Ji J, Chen K, Wang F, Dai W, Fan X, Guo C
Journal of cellular and molecular medicine 2020 May;24(9):5224-5237
Journal of cellular and molecular medicine 2020 May;24(9):5224-5237
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
Su C, Wang Q, Luo H, Jiao W, Tang J, Li L, Tian L, Chen X, Liu B, Yu X, Li S, Guo S, Wang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma.
Zheng S, Wan L, Ge D, Jiang F, Qian Z, Tang J, Yang J, Yao Y, Yan J, Zhao L, Li H, Yang L
Cell death & disease 2020 Jul 24;11(7):576
Cell death & disease 2020 Jul 24;11(7):576
Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-β signals.
Fan P, Li Z, Zuo C, Fang M
Cell biochemistry and function 2020 Jan;38(1):38-46
Cell biochemistry and function 2020 Jan;38(1):38-46
Raw and vinegar processed Curcuma wenyujin regulates hepatic fibrosis via bloking TGF-β/Smad signaling pathways and up-regulation of MMP-2/TIMP-1 ratio.
Xie H, Su D, Zhang J, Ji, Mao J, Hao M, Wang Q, Yu M, Mao C, Lu T
Journal of ethnopharmacology 2020 Jan 10;246:111768
Journal of ethnopharmacology 2020 Jan 10;246:111768
Retinal pigment epithelial cells secrete miR-202-5p-containing exosomes to protect against proliferative diabetic retinopathy.
Gu S, Liu Y, Zou J, Wang W, Wei T, Wang X, Zhu L, Zhang M, Zhu J, Xie T, Yao Y, Qiu L
Experimental eye research 2020 Dec;201:108271
Experimental eye research 2020 Dec;201:108271
miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling.
Xu P, Li Z, Wang Y, Yu X, Shao X, Li YX, Peng C, Zhao Y, Wang YL
Molecular therapy. Nucleic acids 2020 Dec 4;22:542-556
Molecular therapy. Nucleic acids 2020 Dec 4;22:542-556
LncRNA Gm16410 regulates PM2.5-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway.
Ma K, Li C, Xu J, Ren F, Xu X, Liu C, Niu B, Li F
Ecotoxicology and environmental safety 2020 Dec 1;205:111327
Ecotoxicology and environmental safety 2020 Dec 1;205:111327
MicroRNA-148a-3p inhibits progression of hepatocelluar carcimoma by repressing SMAD2 expression in an Ago2 dependent manner.
Huang Z, Wen J, Yu J, Liao J, Liu S, Cai N, Liang H, Chen X, Ding Z, Zhang B
Journal of experimental & clinical cancer research : CR 2020 Aug 4;39(1):150
Journal of experimental & clinical cancer research : CR 2020 Aug 4;39(1):150
Inhibitory Effect of Corilagin on miR-21-Regulated Hepatic Fibrosis Signaling Pathway.
Zhou X, Xiong J, Lu S, Luo L, Chen ZL, Yang F, Jin F, Wang Y, Ma Q, Luo YY, Wang YJ, Zhou JB, Liu P, Zhao L
The American journal of Chinese medicine 2019;47(7):1541-1569
The American journal of Chinese medicine 2019;47(7):1541-1569
A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway.
Tran BH, Yu Y, Chang L, Tan B, Jia W, Xiong Y, Dai T, Zhong R, Zhang W, Le VM, Rose P, Wang Z, Mao Y, Zhu YZ
International journal of nanomedicine 2019;14:10061-10077
International journal of nanomedicine 2019;14:10061-10077
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
Shao Q, Jiang C, Xia Y, Zhao M, Zhang Q, Jin B, Liu J
International journal of clinical and experimental pathology 2019;12(3):867-875
International journal of clinical and experimental pathology 2019;12(3):867-875
POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.
Wang B, Xu X, Yang Z, Zhang L, Liu Y, Ma A, Xu G, Tang M, Jing T, Wu L, Liu Y
EBioMedicine 2019 Mar;41:320-332
EBioMedicine 2019 Mar;41:320-332
MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer.
He W, Liang B, Wang C, Li S, Zhao Y, Huang Q, Liu Z, Yao Z, Wu Q, Liao W, Zhang S, Liu Y, Xiang Y, Liu J, Shi M
Oncogene 2019 Jun;38(23):4637-4654
Oncogene 2019 Jun;38(23):4637-4654
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Xue K, Zhang J, Li C, Li J, Wang C, Zhang Q, Chen X, Yu X, Sun L, Yu X
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
Platelets promote invasion and induce epithelial to mesenchymal transition in ovarian cancer cells by TGF-β signaling pathway.
Guo Y, Cui W, Pei Y, Xu D
Gynecologic oncology 2019 Jun;153(3):639-650
Gynecologic oncology 2019 Jun;153(3):639-650
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
Yuan J, Tan L, Yin Z, Zhu W, Tao K, Wang G, Shi W, Gao J
Cell death & disease 2019 Jun 11;10(6):454
Cell death & disease 2019 Jun 11;10(6):454
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
Hu B, Mao Z, Du Q, Jiang X, Wang Z, Xiao Z, Zhu D, Wang X, Zhu Y, Wang H
Brain research bulletin 2019 Jul;149:21-31
Brain research bulletin 2019 Jul;149:21-31
HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways.
Lei R, Li J, Liu F, Li W, Zhang S, Wang Y, Chu X, Xu J
Cell cycle (Georgetown, Tex.) 2019 Dec;18(23):3239-3250
Cell cycle (Georgetown, Tex.) 2019 Dec;18(23):3239-3250
LRG1 Promotes Apoptosis and Autophagy through the TGFβ-smad1/5 Signaling Pathway to Exacerbate Ischemia/Reperfusion Injury.
Jin J, Sun H, Liu D, Wang H, Liu Q, Chen H, Zhong D, Li G
Neuroscience 2019 Aug 10;413:123-134
Neuroscience 2019 Aug 10;413:123-134
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
Zhao J, Meng M, Zhang J, Li L, Zhu X, Zhang L, Wang C, Gao M
Molecular medicine reports 2019 Apr;19(4):3168-3178
Molecular medicine reports 2019 Apr;19(4):3168-3178
A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma.
Lewis DM, Pruitt H, Jain N, Ciccaglione M, McCaffery JM, Xia Z, Weber K, Eisinger-Mathason TSK, Gerecht S
Cancer research 2019 Apr 15;79(8):1981-1995
Cancer research 2019 Apr 15;79(8):1981-1995
Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway.
Ye X, He L, Ma J, Li Y, Zhang M, Yang J, Zhang J, Xiao F, Wei H
Molecular medicine reports 2018 Oct;18(4):3611-3618
Molecular medicine reports 2018 Oct;18(4):3611-3618
Role of TGF-β1/Smad3-mediated fibrosis in drug resistance mechanism of prolactinoma.
Hu B, Mao Z, Jiang X, He D, Wang Z, Wang X, Zhu Y, Wang H
Brain research 2018 Nov 1;1698:204-212
Brain research 2018 Nov 1;1698:204-212
MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.
Li J, Zou K, Yu L, Zhao W, Lu Y, Mao J, Wang B, Wang L, Fan S, Song B, Li L
Molecular therapy. Nucleic acids 2018 Mar 2;10:426-437
Molecular therapy. Nucleic acids 2018 Mar 2;10:426-437
PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.
Zhao B, Liu L, Mao J, Zhang Z, Wang Q, Li Q
Cell death & disease 2018 Feb 22;9(3):307
Cell death & disease 2018 Feb 22;9(3):307
Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway.
Xiao Y, Ye J, Zhou Y, Huang J, Liu X, Huang B, Zhu L, Wu B, Zhang G, Cai Y
Archives of biochemistry and biophysics 2018 Feb 15;640:37-46
Archives of biochemistry and biophysics 2018 Feb 15;640:37-46
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
Wang EM, Fan QL, Yue Y, Xu L
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.
Yan L, You WQ, Sheng NQ, Gong JF, Hu LD, Tan GW, Chen HQ, Wang ZG
Aging 2018 Dec 6;10(12):3774-3793
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Biochemical pharmacology 2018 Aug;154:203-212
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Stem cell reports 2018 Apr 10;10(4):1267-1281
Stem cell reports 2018 Apr 10;10(4):1267-1281
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Cai Y, Ma W, Xiao Y, Wu B, Li X, Liu F, Qiu J, Zhang G
Toxicology and applied pharmacology 2017 Oct 15;333:1-9
Toxicology and applied pharmacology 2017 Oct 15;333:1-9
Transforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling.
Zhang X, Fan Q, Li Y, Yang Z, Yang L, Zong Z, Wang B, Meng X, Li Q, Liu J, Li H
Oncotarget 2017 May 2;8(18):29785-29794
Oncotarget 2017 May 2;8(18):29785-29794
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Biochemical and biophysical research communications 2017 Mar 11;484(3):514-521
Biochemical and biophysical research communications 2017 Mar 11;484(3):514-521
Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer.
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Oncogenesis 2017 Jan 9;6(1):e284
Oncogenesis 2017 Jan 9;6(1):e284
Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.
Zhao B, Liu L, Mao J, Liu K, Fan W, Liu J, Zhang Z, Li Q
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1036-1044
CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
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Oncotarget 2017 Dec 29;8(70):114506-114525
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Vascular pharmacology 2016 Jun;81:83-90
In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse.
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International journal of molecular medicine 2016 Jul;38(1):95-104
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Molecules (Basel, Switzerland) 2016 Jan 18;21(1):102
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Journal of experimental & clinical cancer research : CR 2016 Aug 30;35(1):130
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The American journal of Chinese medicine 2015;43(2):231-40
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Scientific reports 2015 Apr 8;5:9713
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Mediators of inflammation 2014;2014:954502
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Biochemical and biophysical research communications 2014 May 16;447(4):689-95
The role of SIRT6 in the differentiation of vascular smooth muscle cells in response to cyclic strain.
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The international journal of biochemistry & cell biology 2014 Apr;49:98-104
The international journal of biochemistry & cell biology 2014 Apr;49:98-104
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PloS one 2013;8(3):e59002
PloS one 2013;8(3):e59002
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Journal of cellular and molecular medicine 2012 Jan;16(1):118-28
Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease.
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Journal of cellular and molecular medicine 2012 Feb;16(2):249-59
Journal of cellular and molecular medicine 2012 Feb;16(2):249-59
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 12570-1-AP(SMAD2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using SMAD2 antibody 12570-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human endometrial cancer using 12570-1-AP(SMAD2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue