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- Antibody Data
- Antigen structure
- References [234]
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- Product number
- 12570-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12570-1-AP, RRID:AB_2193037
- Product name
- SMAD2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SMAD2 antibody (Cat. #12570-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mapping Immune-Inflammatory Niches on Zirconia Bone Implants: Single-Cell Transcriptomic Profiling.
Intracavernous Injection of Mechanically Extracted Stromal Vascular Fragments Suppresses Endothelial-Mesenchymal Transformation to Mitigate Erectile Dysfunction in Hypertensive Rats.
Cathepsin E drives colorectal cancer progression and immune evasion via ZNF326 ADP-ribosylation and TGF-β/SMAD activation.
CACNB2 overexpression suppresses atrial fibroblast activation and atrial fibrosis to mitigate atrial fibrillation.
HDAC6 orchestrates metastatic and immunosuppressive programs in small cell lung cancer through S100A2-TGF-β/SMAD and CSF1R signaling.
SMAD2 ubiquitination through PY motif regulates skeletal muscle mass and fibrotic degeneration.
PARP1 stabilizes FOXN3 to suppress pulmonary fibrosis through p38-related feedback regulation.
Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF-κB and TGF-β Signaling Pathways.
Lactate Promotes Endothelial-Mesenchymal Transition via Mediating Twist1 Lactylation in Hypoxic Pulmonary Hypertension.
Targeting ADAMTS1/HDAC6 alleviates TGF-β1/SMAD2-associated cardiac fibrosis in cardiac fibrosis post-myocardial infarction.
SULT1E1 suppresses hepatocellular carcinoma progression via activation of the TGF-β/SMAD signaling pathway and cell cycle arrest.
Cyanoglycosides isolated from Moringa oleifera seeds inhibited PFKFB3/TGF-β1/smads pathway to alleviate diabetic nephropathy through driving metabolic reprogramming.
PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF-β/Smad Signalling Pathway.
Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis.
Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway.
TGF-β-Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization.
Lactobacillus rhamnosus GG attenuates MASLD/MASH progression by modulating gut microbiota and metabolic pathways.
Single-cell RNA sequencing reveals that myeloid S100A8/A9 is a novel regulator of the transition from adaptive hypertrophy to heart failure after pressure overload.
Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.
Spatial transcriptomics reveals Inhba/Smad2/E2f4 axis in Lrp2(high) thecal cell proliferation in androgen-induced PCOS mice.
Integrin αvβ6 mediates the effects of age-related decreases in matrix stiffness on Tenon's fibroblast activation and bleb scarring in glaucoma.
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Decabromodiphenyl ethane induces intrauterine growth restriction by suppressing placental angiogenesis via TWIST2/NAT10-mediated ac4C-dependent TGF-β1 mRNA stabilization.
Rhein alleviates renal interstitial fibrosis by inhibiting Smad3 phosphorylation in TGF-β/Smad signalling pathway.
CRABP2 promotes peritoneal metastasis in CRC through TGF-β/Smad-mediated EMT signaling and invadopodia formation.
Fecal Microbiota Transplantation Attenuated Inflammation Through TGF-β1/Smad Signaling Pathway in Caco-2 and RAW264.7 Cells.
METTL3/IGF2BP2 stabilizes IQGAP3 via m6A modification to drive HCC metastasis through TGF-β/Smad signaling and EMT.
Multi-Omics and Molecular Dynamics Analysis for Biomarker Discovery in Chronic Rhinosinusitis With Nasal Polyps.
Histone demethylase KDM9 activates the CCND1/AKT pathway to promote the malignant progression of gliomas through interaction with BRD2.
IGF2BP3 regulates EMP1 stability in an m(6)A-dependent manner and activates the TGF-β pathway to promote pancreatic cancer invasion.
Mechanistic insights into Y-Box binding protein-1 mediated regulation of lipid metabolism and oxidative stress in NAFLD via INHBE/TNF-β pathway.
Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment.
Mesenchymal stem cell exosomes regulate TGFβ/Smad3 by decreasing the METTL3-NEAT1 axis to inhibit scar progression after breast surgery.
LINC00525 promotes cell proliferation and collagen expression through feedforward regulation of TGF-β signaling in hypertrophic scar fibroblasts.
Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC.
Ergothioneine Ameliorates Liver Fibrosis by Inhibiting Glycerophospholipids Metabolism and TGF-β/Smads Signaling Pathway: Based on Metabonomics and Network Pharmacology.
Anti-fibrosis effect and its mechanism of atractylenolide III on post-traumatic extending knee joint contracture in rats.
Dietary phytosterol supplementation mitigates renal fibrosis via activating mitophagy and modulating the gut microbiota.
Effect of COL11A1 on oral squamous cell carcinoma.
Network pharmacology analysis reveals that coumestrol targets ZYX to inhibit ferroptosis and alleviate acute pancreatitis.
ACSL4 accelerates osteosarcoma progression via modulating TGF-β/Smad2 signaling pathway.
Activin A promoted the anti-tumor effect of ActRIIA (high) CD8(+) T cells in mouse hepatoma.
Inhibition of Endothelial-Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats.
Astragali Radix-Angelicae Sinensis Radix inhibits the activation of vascular adventitial fibroblasts and vascular intimal proliferation by regulating the TGF-β1/Smad2/3 pathway.
Low-dose SAHA enhances CD8(+) T cell-mediated antitumor immunity by boosting MHC I expression in non-small cell lung cancer.
Negative air ions alleviate nicotine-induced renal damage of spontaneously hypertensive rats via inhibiting oxidative stress and TGF-β/Smad pathway.
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis.
Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling.
Discovery of novel capsaicin analogs as TRPV1 inhibitors for the treatment of idiopathic pulmonary fibrosis.
Cryoablation-induced modulation of Treg cells and the TGF-β pathway in lung adenocarcinoma: implications for increased antitumor immunity.
Renal Denervation Improves Myocardial Mitochondrial Dysfunction and Myocardial Fibrosis by Inhibiting the NE/KLF15/renalase Pathway.
Interplay of HIF-1α, SMAD2, and VEGF signaling in hypoxic renal environments: impact on macrophage polarization and renoprotection.
AMPK regulates the anti-pulmonary fibrosis effects of tracheloside.
Protodioscin enhances Methotrexate-induced senescence and senolytic activity in HepG2 liver cancer spheroids by modulating cell cycle regulators and the TGF-β/p-Smad2-4 signaling pathway.
HIC2 suppresses glioblastoma progression via transcriptional repression of SEMA3A and inhibition of TGF-β signaling.
Calcineurin/NFAT1/Smad2 signaling regulates microglial autophagy that contributes to neuroinflammation and cognitive deficit in mice with sepsis-associated encephalopathy.
Tanshinone IIA ameliorates septic immunosuppression by balancing the Th17/Treg cell ratio and modulating Treg function after induction of autophagy.
Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression.
Inhibitory effect of SMAD2 on myogenesis in heat-stressed Hu sheep myoblasts.
Integrated Proteomics Reveals Spliceosome Dysregulation and Highlights DHX9 as a TGF-β Signaling-Driven Fibrosis Hub in Endometriosis.
SOX17 Prevents Endothelial-Mesenchymal Transition of Pulmonary Arterial Endothelial Cells in Pulmonary Hypertension through Mediating TGF-β/Smad2/3 Signaling.
Sodium Hyaluronate-PDGF Repairs Cartilage and Subchondral Bone Microenvironment via HIF-1α-VEGF-Notch and SDF-1-CXCR4 Inhibition in Osteoarthritis.
ErTao decoction alleviates liver fibrosis by suppressing STING-mediated macrophages and NLRP3 inflammasome activation.
Cornua cervi degelatinatum inhibits breast cancer stem-like cell properties and metastasis via miR-148a-3p-mediated TGF-β/Smad2 pathway.
Autophagy inhibition enhances antifibrotic potential of placental mesenchymal stem cells of fetal origin via regulating TGF-β1 mediated protein degradation of HGF.
Astragaloside I from Astragalus Attenuates Diabetic Kidney Disease by Regulating HDAC3/Klotho/TGF-β1 Loop.
Combination of Pirfenidone and Andrographolide Ameliorates Hepatic Stellate Cell Activation and Liver Fibrosis by Mediating TGF-β/Smad Signaling Pathway.
Hypoxia-driven TNS4 fosters HNSCC tumorigenesis by stabilizing integrin α5β1 complex and triggering FAK-mediated Akt and TGFβ signaling pathways.
Therapeutic Effects of Qingchang Tongluo Decoction on Intestinal Fibrosis in Crohn's Disease: Network Pharmacology, Molecular Docking and Experiment Validation.
FATP5 modulates biological activity and lipid metabolism in prostate cancer through the TEAD4-mediated Hippo signaling.
Mechanism of Zhenwu Decoction modulating TLR4/NF-κB/HIF-1α loop through miR-451 to delay renal fibrosis in type 2 CRS.
Activin E upregulates uncoupling protein 1 and fibroblast growth factor 21 in brown adipocytes.
Macrophage exosomal miR-30c-2-3p in atherosclerotic plaques aggravates microglial neuroinflammation during large-artery atherosclerotic stroke via TGF-β/SMAD2 pathway.
Strategies for arterial graft optimization at the single-cell level.
The circadian clock gene, BMAL1, promotes radiosensitization in nasopharyngeal carcinoma by inhibiting the epithelial-to-mesenchymal transition via the TGF-β1/Smads/Snail1 axis.
Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways.
Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
The miR-3074/BMP7 axis regulates TGF-β-caused activation of hepatic stellate cells in vitro and CCl(4)-caused murine liver fibrosis in vivo.
Ginsenoside RH4 inhibits Ang II-induced myocardial remodeling by interfering with NFIL3.
BATF promotes extramedullary infiltration through TGF-β1/Smad/MMPs axis in acute myeloid leukemia.
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
Chitosan-modified dihydromyricetin liposomes promote the repair of liver injury in mice suffering from diabetes mellitus.
Differentiation of Uc-MSCs into insulin secreting islet-like clusters by trypsin through TGF-beta signaling pathway.
MET exon 14 skipping mutation drives cancer progression and recurrence via activation of SMAD2 signalling.
HDAC6-selective inhibitor CAY10603 ameliorates cigarette smoke-induced small airway remodeling by regulating epithelial barrier dysfunction and reversing.
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution.
Icariin Regulates EMT and Stem Cell-Like Character in Breast Cancer through Modulating lncRNA NEAT1/TGFβ/SMAD2 Signaling Pathway.
miR-134-3p Regulates Cell Proliferation and Apoptosis by Targeting INHBA via Inhibiting the TGF-β/PI3K/AKT Pathway in Sheep Granulosa Cells.
Vaspin facilitates the proliferation and osteogenic differentiation of periodontal ligament stem cells.
SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress.
Knockdown of long noncoding RNA AL161431.1 inhibits malignant progression of cholangiocarcinoma.
Herb pair of Rhubarb-Astragalus mitigates renal interstitial fibrosis through downregulation of autophagy via p38-MAPK/TGF-β1 and p38-MAPK/smad2/3 pathways.
N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1.
The NF-κB/NUAK2 signaling axis regulates pancreatic cancer progression by targeting SMAD2/3.
Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling.
Total alkaloids of bulbus of Fritillaria cirrhosa alleviate bleomycin-induced inflammation and pulmonary fibrosis in rats by inhibiting TGF-β and NF-κB signaling pathway.
Identification and Characterization of a Novel Nanobody Against Human CTGF to Reveal Its Antifibrotic Effect in an in vitro Model of Liver Fibrosis.
Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α.
IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer.
An miRNA-mRNA integrative analysis in human placentas and mice: role of the Smad2/miR-155-5p axis in the development of fetal growth restriction.
The m6A reader YTHDC1-mediated lncRNA CTBP1-AS2 m6A modification accelerates cholangiocarcinoma progression.
Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcoma.
A nano-conductive osteogenic hydrogel to locally promote calcium influx for electro-inspired bone defect regeneration.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
The hsa_circ_0004805/hsa_miR-149-5p/TGFB2 axis plays critical roles in the pathophysiology of diabetic retinopathy in vitro and in vivo.
Yishen Tongluo formula alleviates diabetic kidney disease through regulating Sirt6/TGF-β1/Smad2/3 pathway and promoting degradation of TGF-β1.
Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins.
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF-β/SMAD signalling.
Down-regulation of the Smad signaling by circZBTB46 via the Smad2-PDLIM5 axis to inhibit type I collagen expression.
Sacha inchi albumin delays skin-aging by alleviating inflammation, oxidative stress and regulating gut microbiota in d-galactose induced-aging mice.
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
The miR-103a-3p/TGFBR3 axis regulates TGF-β-induced orbital fibroblast activation and fibrosis in thyroid-eye disease.
Hepatic stellate cell-released CXCL1 aggravates HCC malignant behaviors through the MIR4435-2HG/miR-506-3p/TGFB1 axis.
KNTC1, regulated by HPV E7, inhibits cervical carcinogenesis partially through Smad2.
Exosomes derived from human dermal fibroblasts protect against UVB‑induced skin photoaging.
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.
Inhibition of TGF-β1-induced epithelial-mesenchymal transition in gliomas by DMC-HA.
Exosomal ITGB6 from dormant lung adenocarcinoma cells activates cancer-associated fibroblasts by KLF10 positive feedback loop and the TGF-β pathway.
The chromatin remodeling protein BRG1 regulates HSC-myofibroblast differentiation and liver fibrosis.
Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.
HOXA11 promotes lymphatic metastasis of gastric cancer via transcriptional activation of TGFβ1.
Adipose-derived mesenchymal stem cell therapy for reverse bleomycin-induced experimental pulmonary fibrosis.
CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF-β/Smad signaling.
Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-β1/Smad Signaling.
Loureirin A Exerts Antikeloid Activity by Antagonizing the TGF-β1/Smad Signalling Pathway.
Multifunctional Drug-Loaded Phase-Change Nanoparticles Inhibit the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Affecting the Activity of Activated Hepatic Stellate Cells.
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Pyrrosia petiolosa Extract Ameliorates Ethylene Glycol-Induced Urolithiasis in Rats by Inhibiting Oxidative Stress and Inflammatory Response.
GPC1 promotes the growth and migration of colorectal cancer cells through regulating the TGF-β1/SMAD2 signaling pathway.
NR4A1 inhibits the epithelial-mesenchymal transition of hepatic stellate cells: Involvement of TGF-β-Smad2/3/4-ZEB signaling.
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling.
A robust CD8(+) T cell-related classifier for predicting the prognosis and efficacy of immunotherapy in stage III lung adenocarcinoma.
Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models.
Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa.
NCAPH regulates gastric cancer progression through DNA damage response.
Comparative analyses in transcriptome of human granulosa cells and follicular fluid micro-environment between poor ovarian responders with conventional controlled ovarian or mild ovarian stimulations.
Long noncoding RNA Lnc-DIF inhibits bone formation by sequestering miR-489-3p.
The Novel Competing Endogenous Long Noncoding RNA SM2 Regulates Gonadotropin Secretion in the Hu Sheep Anterior Pituitary by Targeting the Oar-miR-16b/TGF-β/SMAD2 Signaling Pathway.
Adiponectin Alleviates Intestinal Fibrosis by Enhancing AMP-Activated Protein Kinase Phosphorylation.
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Gli(ko) BMSC: A potential strategy of treatment for renal fibrosis.
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer.
Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice.
Hyperglycemia induces miR-26-5p down-regulation to overexpress PFKFB3 and accelerate epithelial-mesenchymal transition in gastric cancer.
Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway.
CeO(2) nanoparticles induce pulmonary fibrosis via activating S1P pathway as revealed by metabolomics.
Extracellular HSP90α promotes cellular senescence by modulating TGF-β signaling in pulmonary fibrosis.
Botox-A improve the thyroid-associated ophthalmopathy (TAO) orbital fibroblast activation through inhibiting the TGF-β/Smad signaling.
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Elevated IgE promotes cardiac fibrosis by suppressing miR-486a-5p.
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro.
Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling.
Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway.
The miR-182/Myadm axis regulates hypoxia-induced pulmonary hypertension by balancing the BMP- and TGF-β-signalling pathways in an SMC/EC-crosstalk-associated manner.
Bergenin attenuates bleomycin-induced pulmonary fibrosis in mice via inhibiting TGF-β1 signaling pathway.
SMAD2 regulates testicular development and testosterone synthesis in Hu sheep.
An experimental model of the epithelial to mesenchymal transition and pro-fibrogenesis in urothelial cells related to bladder pain syndrome/interstitial cystitis.
Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway.
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-β1/Smad pathway.
Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells (HSCs) in vitro and CCl(4)-induced hepatic fibrosis in rats in vivo.
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.
PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis.
SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion.
Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions.
MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein.
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2.
Ligand-independent EphB1 signaling mediates TGF-β-activated CDH2 and promotes lung cancer cell invasion and migration.
Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway.
KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway.
Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing.
TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis.
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma.
Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-β signals.
Raw and vinegar processed Curcuma wenyujin regulates hepatic fibrosis via bloking TGF-β/Smad signaling pathways and up-regulation of MMP-2/TIMP-1 ratio.
Retinal pigment epithelial cells secrete miR-202-5p-containing exosomes to protect against proliferative diabetic retinopathy.
miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling.
LncRNA Gm16410 regulates PM(2.5)-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway.
MicroRNA-148a-3p inhibits progression of hepatocelluar carcimoma by repressing SMAD2 expression in an Ago2 dependent manner.
Inhibitory Effect of Corilagin on miR-21-Regulated Hepatic Fibrosis Signaling Pathway.
A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway.
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.
MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer.
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Platelets promote invasion and induce epithelial to mesenchymal transition in ovarian cancer cells by TGF-β signaling pathway.
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways.
LRG1 Promotes Apoptosis and Autophagy through the TGFβ-smad1/5 Signaling Pathway to Exacerbate Ischemia/Reperfusion Injury.
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma.
Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway.
Role of TGF-β1/Smad3-mediated fibrosis in drug resistance mechanism of prolactinoma.
MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.
PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.
Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway.
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.
Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization.
Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients.
High doses of baicalin induces kidney injury and fibrosis through regulating TGF-β/Smad signaling pathway.
Transforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling.
Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop.
Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer.
Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy.
Metformin alleviates vascular calcification induced by vitamin D3 plus nicotine in rats via the AMPK pathway.
In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse.
Phenylethanol Glycosides from Cistanche tubulosa Suppress Hepatic Stellate Cell Activation and Block the Conduction of Signaling Pathways in TGF-β1/smad as Potential Anti-Hepatic Fibrosis Agents.
Interplay between intergrin-linked kinase and ribonuclease inhibitor affects growth and metastasis of bladder cancer through signaling ILK pathways.
Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice.
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Potent effects of dioscin against liver fibrosis.
Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy.
TGF-β2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF.
The role of SIRT6 in the differentiation of vascular smooth muscle cells in response to cyclic strain.
Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice.
Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis.
Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease.
Zhou J, Li A, Chen J, Dai J, Zhang W, Yang Z, Li P
Research (Washington, D.C.) 2026;9:1162
Research (Washington, D.C.) 2026;9:1162
Intracavernous Injection of Mechanically Extracted Stromal Vascular Fragments Suppresses Endothelial-Mesenchymal Transformation to Mitigate Erectile Dysfunction in Hypertensive Rats.
Shao C, Sun Y, Zhao J, Ju C, Yang T, Liu J, Zhou L, Jia R, Zhao F
Stem cells international 2026;2026:3343152
Stem cells international 2026;2026:3343152
Cathepsin E drives colorectal cancer progression and immune evasion via ZNF326 ADP-ribosylation and TGF-β/SMAD activation.
Zhang H, Feng J, Zhu M, Shi T, Xi Q
Journal of translational medicine 2026 Mar 14;24(1)
Journal of translational medicine 2026 Mar 14;24(1)
CACNB2 overexpression suppresses atrial fibroblast activation and atrial fibrosis to mitigate atrial fibrillation.
Zhang D, Li Z, Li N, Zhang H
Cellular signalling 2026 Jul;143:112448
Cellular signalling 2026 Jul;143:112448
HDAC6 orchestrates metastatic and immunosuppressive programs in small cell lung cancer through S100A2-TGF-β/SMAD and CSF1R signaling.
Jiang Y, Yu J, Wang T, Du Q, Wang J, Lu Y, Xu Q, Liu H, Li X, Tong L, Qin T, Huang D
Molecular cancer 2026 Jan 7;25(1):33
Molecular cancer 2026 Jan 7;25(1):33
SMAD2 ubiquitination through PY motif regulates skeletal muscle mass and fibrotic degeneration.
Yamasaki Y, Sakamoto K, Yashiro S, Kawa Y, Kondow A, Kubo A, Hitachi K, Inui M
Scientific reports 2026 Jan 30;16(1):6666
Scientific reports 2026 Jan 30;16(1):6666
PARP1 stabilizes FOXN3 to suppress pulmonary fibrosis through p38-related feedback regulation.
Zhu X, Huo Q, Jin L, Du J, Yu J, Wang H, Wu N, Li Y, Rui Y, Zhao C, Zhou J, Zhang Y, Li H, Lin J, Zheng C, Li W
Science advances 2026 Jan 2;12(1):eady1681
Science advances 2026 Jan 2;12(1):eady1681
Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF-κB and TGF-β Signaling Pathways.
Ye S, Xiang J, Zhou S, Ge Q, Anwaier A, Chang K, Wei G, Lu J, Tian X, Zhu S, Jiang Y, Zhang W, Cai T, Xu M, Ye D, Xu D, Wang T, Zhang H, Xu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e18500
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e18500
Lactate Promotes Endothelial-Mesenchymal Transition via Mediating Twist1 Lactylation in Hypoxic Pulmonary Hypertension.
Li X, Wang F, Liu N, Liu Y, Yu W, Tang M
International journal of molecular sciences 2026 Feb 27;27(5)
International journal of molecular sciences 2026 Feb 27;27(5)
Targeting ADAMTS1/HDAC6 alleviates TGF-β1/SMAD2-associated cardiac fibrosis in cardiac fibrosis post-myocardial infarction.
Jin Q, Chen C, Wu P, Li L, Jiang L, Chen R, Xu S, Huang Y, Xu H, Long X
Cell biology and toxicology 2026 Feb 12;42(1)
Cell biology and toxicology 2026 Feb 12;42(1)
SULT1E1 suppresses hepatocellular carcinoma progression via activation of the TGF-β/SMAD signaling pathway and cell cycle arrest.
Zhang W, Peng J, Dai D, Huang C, Liu F, Chen X
BMC gastroenterology 2026 Feb 11;26(1)
BMC gastroenterology 2026 Feb 11;26(1)
Cyanoglycosides isolated from Moringa oleifera seeds inhibited PFKFB3/TGF-β1/smads pathway to alleviate diabetic nephropathy through driving metabolic reprogramming.
Ge C, Shi Z, He J, Feng X, Shang K, Liao X, Liu Y, Jiang Y, Liu S
Pharmaceutical biology 2026 Dec;64(1):130-142
Pharmaceutical biology 2026 Dec;64(1):130-142
PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF-β/Smad Signalling Pathway.
Zhang H, Zhang L, Feng Z, Li X, Qiu Z, Wang X, Qian L
Cell proliferation 2026 Apr;59(4):e70123
Cell proliferation 2026 Apr;59(4):e70123
Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis.
Li BB, Zhang JT, Jiang YY, Li X, Wang DN, Zang JM, Liu ZL, Hu FX, Zhu X, Shen CC, Zhang W, Xu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 19;156:158220
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 19;156:158220
Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway.
Feng L, Xiao G, Chen Y, Ye T, Fan L, Xie Y, Mei T, Wang L, Ge J, Ye C, Chen J
International journal of biological sciences 2025;21(9):4153-4171
International journal of biological sciences 2025;21(9):4153-4171
TGF-β-Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization.
Ma W, Ma Y, Bai Y, Guo C, Zhang Q, Su X
Open medicine (Warsaw, Poland) 2025;20(1):20251279
Open medicine (Warsaw, Poland) 2025;20(1):20251279
Lactobacillus rhamnosus GG attenuates MASLD/MASH progression by modulating gut microbiota and metabolic pathways.
Wang SL, Liang S, Li SY, Fu JW, Wang ZY, Zhu DQ, Chen N
Frontiers in microbiology 2025;16:1586678
Frontiers in microbiology 2025;16:1586678
Single-cell RNA sequencing reveals that myeloid S100A8/A9 is a novel regulator of the transition from adaptive hypertrophy to heart failure after pressure overload.
Yu WJ, Jiang WX, Liu SJ, Li HH, Lin QY
Theranostics 2025;15(16):8587-8608
Theranostics 2025;15(16):8587-8608
Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.
Song S, Song Y
Frontiers in oncology 2025;15:1629962
Frontiers in oncology 2025;15:1629962
Spatial transcriptomics reveals Inhba/Smad2/E2f4 axis in Lrp2(high) thecal cell proliferation in androgen-induced PCOS mice.
Luo M, Tian X, Li L, Zhang G, Liu W, Mei L, Li H, You X, Zhang D, Zhou M, Xiao C, Ye J, Yang X
Frontiers in cell and developmental biology 2025;13:1633254
Frontiers in cell and developmental biology 2025;13:1633254
Integrin αvβ6 mediates the effects of age-related decreases in matrix stiffness on Tenon's fibroblast activation and bleb scarring in glaucoma.
Feng L, Xiong W, Yin J, Guan D, Li H, Cao J, Zhu Z, Zhang W, Zhang F
Experimental eye research 2025 Sep;258:110459
Experimental eye research 2025 Sep;258:110459
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Ma Y, Huang J, Gong J, Li L, Zhao Y, Jin Y, Gu J, Liu H, Wang Y, Sun Y
Chinese medicine 2025 Sep 22;20(1):146
Chinese medicine 2025 Sep 22;20(1):146
Decabromodiphenyl ethane induces intrauterine growth restriction by suppressing placental angiogenesis via TWIST2/NAT10-mediated ac4C-dependent TGF-β1 mRNA stabilization.
Ling R, Yin X, Ma L, Zhang Y, Ma Y, Gao R, Geng Y, Mu X, Chen X, Li F, He J
Journal of hazardous materials 2025 Sep 15;496:139377
Journal of hazardous materials 2025 Sep 15;496:139377
Rhein alleviates renal interstitial fibrosis by inhibiting Smad3 phosphorylation in TGF-β/Smad signalling pathway.
Zheng X, Wang L, Cheng Y, Lin H, Liu S, Chen X, Xiang Z
Chinese herbal medicines 2025 Oct;17(4):744-755
Chinese herbal medicines 2025 Oct;17(4):744-755
CRABP2 promotes peritoneal metastasis in CRC through TGF-β/Smad-mediated EMT signaling and invadopodia formation.
Hao W, Dong X, Wang Z, Wen T, Liu L, Gu T, Ma H
Cellular signalling 2025 Oct;134:111927
Cellular signalling 2025 Oct;134:111927
Fecal Microbiota Transplantation Attenuated Inflammation Through TGF-β1/Smad Signaling Pathway in Caco-2 and RAW264.7 Cells.
Qiu J, Wu C, Li S, Yang X
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2025 Oct 10;37(2):161-169
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2025 Oct 10;37(2):161-169
METTL3/IGF2BP2 stabilizes IQGAP3 via m6A modification to drive HCC metastasis through TGF-β/Smad signaling and EMT.
Pan D, Zhang H, Zhou J, He S, Yuan G
Pathology, research and practice 2025 Nov;275:156228
Pathology, research and practice 2025 Nov;275:156228
Multi-Omics and Molecular Dynamics Analysis for Biomarker Discovery in Chronic Rhinosinusitis With Nasal Polyps.
Guo Q, Qiao X, Huang S, Wen X, Chen Z, Dong D, Zhao Y
Chemical biology & drug design 2025 Nov;106(5):e70202
Chemical biology & drug design 2025 Nov;106(5):e70202
Histone demethylase KDM9 activates the CCND1/AKT pathway to promote the malignant progression of gliomas through interaction with BRD2.
Cheng J, Peng X, Tang S, Zhou P, Zhou Z, Mao Z, Li D, Yang L, Peng J
Cellular and molecular life sciences : CMLS 2025 Nov 26;82(1):423
Cellular and molecular life sciences : CMLS 2025 Nov 26;82(1):423
IGF2BP3 regulates EMP1 stability in an m(6)A-dependent manner and activates the TGF-β pathway to promote pancreatic cancer invasion.
Liu L, Zhang Y, Huang Y, Zhao X, Fu H, Chen L, Wang Q, Liu X, Zheng X, Zhu H, Fang Z, Gao Z, Yan S
Cell death & disease 2025 Nov 24;16(1):858
Cell death & disease 2025 Nov 24;16(1):858
Mechanistic insights into Y-Box binding protein-1 mediated regulation of lipid metabolism and oxidative stress in NAFLD via INHBE/TNF-β pathway.
Ren Z, Wang R, Wei J, Ma Z, Ke X
Biomolecules & biomedicine 2025 May 8;25(7):1528-1539
Biomolecules & biomedicine 2025 May 8;25(7):1528-1539
Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment.
Bi L, Wang J, Yang J, Zhuang Z, Chen K, Xu Z, Zuo X, Xu J, Sheng Y, Cui Y
Clinical proteomics 2025 May 29;22(1):22
Clinical proteomics 2025 May 29;22(1):22
Mesenchymal stem cell exosomes regulate TGFβ/Smad3 by decreasing the METTL3-NEAT1 axis to inhibit scar progression after breast surgery.
Du J, Wu J, Song Q, Li S, Hong Y, Anwar A, Fu Q, Liu J
Journal of molecular histology 2025 May 20;56(3):161
Journal of molecular histology 2025 May 20;56(3):161
LINC00525 promotes cell proliferation and collagen expression through feedforward regulation of TGF-β signaling in hypertrophic scar fibroblasts.
Chen L, Yin Y, Li J, Li Q, Zhu Z, Li J
Burns : journal of the International Society for Burn Injuries 2025 Mar;51(2):107353
Burns : journal of the International Society for Burn Injuries 2025 Mar;51(2):107353
Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC.
Wang J, Lv ZY, Li P, Zhang Y, Li X, Shen DF
Molecular and cellular biochemistry 2025 Mar;480(3):1611-1625
Molecular and cellular biochemistry 2025 Mar;480(3):1611-1625
Ergothioneine Ameliorates Liver Fibrosis by Inhibiting Glycerophospholipids Metabolism and TGF-β/Smads Signaling Pathway: Based on Metabonomics and Network Pharmacology.
Mao Y, Xie Z, Zhang X, Fu Y, Yu X, Deng L, Zhang X, Hou B, Wang X, Ma M, Ren F
Journal of applied toxicology : JAT 2025 Mar;45(3):514-530
Journal of applied toxicology : JAT 2025 Mar;45(3):514-530
Anti-fibrosis effect and its mechanism of atractylenolide III on post-traumatic extending knee joint contracture in rats.
Zhang BB, Xu L, Zhang QB, Wang Y, Chen C, Zhang JN, Rao XL, Zhu BJ, Li XM, Zhu DT, Kan XL, Mao J, Zhang R, Zhou Y
Experimental gerontology 2025 Mar;201:112708
Experimental gerontology 2025 Mar;201:112708
Dietary phytosterol supplementation mitigates renal fibrosis via activating mitophagy and modulating the gut microbiota.
Yang F, Gao Y, Xie S, Yang W, Wang Q, Ye W, Sun L, Zhou J, Feng X
Food & function 2025 Mar 17;16(6):2316-2334
Food & function 2025 Mar 17;16(6):2316-2334
Effect of COL11A1 on oral squamous cell carcinoma.
Liu YH, Li D, Zhang HL, Zhang BH, Song WJ, Li TK
Journal of stomatology, oral and maxillofacial surgery 2025 Jun;126(3S):102183
Journal of stomatology, oral and maxillofacial surgery 2025 Jun;126(3S):102183
Network pharmacology analysis reveals that coumestrol targets ZYX to inhibit ferroptosis and alleviate acute pancreatitis.
Chen J, Xu H, Gao L, Niu L, Huang Z, Liu S, Huang S, Chen Y, Li J, Tan P, Fu W
International immunopharmacology 2025 Jun 26;159:114948
International immunopharmacology 2025 Jun 26;159:114948
ACSL4 accelerates osteosarcoma progression via modulating TGF-β/Smad2 signaling pathway.
Li X, Chen Q, Zhao D, Tan J, Liao R, Gu Y, Zhu J, Zhang H, Xie J, Chen L
Molecular and cellular biochemistry 2025 Jan;480(1):549-562
Molecular and cellular biochemistry 2025 Jan;480(1):549-562
Activin A promoted the anti-tumor effect of ActRIIA (high) CD8(+) T cells in mouse hepatoma.
Hu L, Zhao Y, Zhang X, Ma C
Cancer medicine 2025 Jan;14(1):e70147
Cancer medicine 2025 Jan;14(1):e70147
Inhibition of Endothelial-Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats.
Lu Z, Li Y, Lu C, Meng Z, Bai L, Huang F, Zeng Z
Frontiers in bioscience (Landmark edition) 2025 Jan 7;30(1):26370
Frontiers in bioscience (Landmark edition) 2025 Jan 7;30(1):26370
Astragali Radix-Angelicae Sinensis Radix inhibits the activation of vascular adventitial fibroblasts and vascular intimal proliferation by regulating the TGF-β1/Smad2/3 pathway.
Li W, Xu S, Chen L, Tan W, Deng N, Li Y, Zhang W, Deng C
Journal of ethnopharmacology 2025 Jan 31;340:119302
Journal of ethnopharmacology 2025 Jan 31;340:119302
Low-dose SAHA enhances CD8(+) T cell-mediated antitumor immunity by boosting MHC I expression in non-small cell lung cancer.
Dong W, He B, Cao Y, Yang R, Zhang S, Kong Y, Lu D, Zheng X, Hou Y, Zhu M, Wang C, Yu S, Cui D, Wang H, Wang B
Cellular oncology (Dordrecht, Netherlands) 2025 Feb;48(1):249-264
Cellular oncology (Dordrecht, Netherlands) 2025 Feb;48(1):249-264
Negative air ions alleviate nicotine-induced renal damage of spontaneously hypertensive rats via inhibiting oxidative stress and TGF-β/Smad pathway.
Xiao S, Wei T, Xiao M, An Z, Shan M, Luo Z, Zhou J, Li N, Lu X
Ecotoxicology and environmental safety 2025 Feb;291:117882
Ecotoxicology and environmental safety 2025 Feb;291:117882
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis.
Huo JL, Fu W, Feng Q, Pan S, Liu D, Liu Z
Clinical science (London, England : 1979) 2025 Feb 6;139(3):229-46
Clinical science (London, England : 1979) 2025 Feb 6;139(3):229-46
Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling.
Yu J, Li Y, Li Y, Liu X, Huo Q, Wu N, Zhang Y, Zeng T, Zhang Y, Li HY, Lian J, Zhou J, Moses EJ, Geng J, Lin J, Li W, Zhu X
Nature communications 2025 Feb 21;16(1):1865
Nature communications 2025 Feb 21;16(1):1865
Discovery of novel capsaicin analogs as TRPV1 inhibitors for the treatment of idiopathic pulmonary fibrosis.
Cao Y, Wen Y, Zhou Z, Xi R, Shuai W, Zhang J, Suksamrarn A, Zhang G, Lu XX, Wang F
European journal of medicinal chemistry 2025 Feb 15;284:117229
European journal of medicinal chemistry 2025 Feb 15;284:117229
Cryoablation-induced modulation of Treg cells and the TGF-β pathway in lung adenocarcinoma: implications for increased antitumor immunity.
Lin S, Liu D, Liang T, Zhuang Y, Wang X, Ma S, Li Q, Hu K
BMC medicine 2025 Feb 14;23(1):89
BMC medicine 2025 Feb 14;23(1):89
Renal Denervation Improves Myocardial Mitochondrial Dysfunction and Myocardial Fibrosis by Inhibiting the NE/KLF15/renalase Pathway.
Chen Y, Fu R, Huang M, Liu T, Zeng L, Li X
Molecular neurobiology 2025 Dec;62(12):16001-16014
Molecular neurobiology 2025 Dec;62(12):16001-16014
Interplay of HIF-1α, SMAD2, and VEGF signaling in hypoxic renal environments: impact on macrophage polarization and renoprotection.
Xu Y, Xu J, Li J, Kong X, Mao H, Du Z, Zan J, Xu L, Qian W, Ma Z, Zhu Y, Zhu X
Renal failure 2025 Dec;47(1):2561784
Renal failure 2025 Dec;47(1):2561784
AMPK regulates the anti-pulmonary fibrosis effects of tracheloside.
Li S, Qian R, Xie W, Lin M, Huang X, Deng L, Xiong D, Liu W, Tang S
Chinese journal of natural medicines 2025 Dec;23(12):100005
Chinese journal of natural medicines 2025 Dec;23(12):100005
Protodioscin enhances Methotrexate-induced senescence and senolytic activity in HepG2 liver cancer spheroids by modulating cell cycle regulators and the TGF-β/p-Smad2-4 signaling pathway.
Jafaei Souq A, Ghanbari A, Tabandeh MR, Zamir Nasta T, Faramarzi A, Makalani F, Jalili C
Scientific reports 2025 Dec 22;15(1):44296
Scientific reports 2025 Dec 22;15(1):44296
HIC2 suppresses glioblastoma progression via transcriptional repression of SEMA3A and inhibition of TGF-β signaling.
Zhang L, Yang J, Ke X, Huang N, Zhou D, Cai H
Free radical biology & medicine 2025 Dec 1;240:674-684
Free radical biology & medicine 2025 Dec 1;240:674-684
Calcineurin/NFAT1/Smad2 signaling regulates microglial autophagy that contributes to neuroinflammation and cognitive deficit in mice with sepsis-associated encephalopathy.
Ding R, Hu N, Zhang X, Jiang F, Feng Y, Li Z, Tang S, Li W, Shi H, Si Y
Free radical biology & medicine 2025 Dec 1;240:15-28
Free radical biology & medicine 2025 Dec 1;240:15-28
Tanshinone IIA ameliorates septic immunosuppression by balancing the Th17/Treg cell ratio and modulating Treg function after induction of autophagy.
Ou H, Sun B, Jiang Y, Gao M
Archives of biochemistry and biophysics 2025 Aug;770:110451
Archives of biochemistry and biophysics 2025 Aug;770:110451
Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression.
Tuechler N, Burtscher ML, Garrido-Rodriguez M, Khan MM, Türei D, Tischer C, Kaspar S, Schwarz JJ, Stein F, Rettel M, Kramann R, Savitski MM, Saez-Rodriguez J, Pepperkok R
Molecular systems biology 2025 Aug;21(8):1030-1065
Molecular systems biology 2025 Aug;21(8):1030-1065
Inhibitory effect of SMAD2 on myogenesis in heat-stressed Hu sheep myoblasts.
Lu J, Liu Y, Li H
Journal of thermal biology 2025 Aug;132:104223
Journal of thermal biology 2025 Aug;132:104223
Integrated Proteomics Reveals Spliceosome Dysregulation and Highlights DHX9 as a TGF-β Signaling-Driven Fibrosis Hub in Endometriosis.
Yang M, Zhang L, Ding X, Wei P, Zhang H, Chen J, Zhang Y, Li D, Chen Z, Lin D, Huang Z, Chen Q
Journal of proteome research 2025 Aug 1;24(8):4044-4059
Journal of proteome research 2025 Aug 1;24(8):4044-4059
SOX17 Prevents Endothelial-Mesenchymal Transition of Pulmonary Arterial Endothelial Cells in Pulmonary Hypertension through Mediating TGF-β/Smad2/3 Signaling.
Zou X, Yuan M, Zhou W, Cai A, Cheng Y, Zhan Z, Zhang Y, Pan Z, Hu X, Zheng S, Liu T, Huang P
American journal of respiratory cell and molecular biology 2025 Apr;72(4):364-379
American journal of respiratory cell and molecular biology 2025 Apr;72(4):364-379
Sodium Hyaluronate-PDGF Repairs Cartilage and Subchondral Bone Microenvironment via HIF-1α-VEGF-Notch and SDF-1-CXCR4 Inhibition in Osteoarthritis.
Wang Z, Zhu P, Li H, Ye B, Luo Q, Cheng J, Cai Y
Journal of cellular and molecular medicine 2025 Apr;29(7):e70515
Journal of cellular and molecular medicine 2025 Apr;29(7):e70515
ErTao decoction alleviates liver fibrosis by suppressing STING-mediated macrophages and NLRP3 inflammasome activation.
Jia H, Li J, Chen X, Liu Z, Wu C, Liu C, Zhang J, Luo M, Huang M, Huang S, Cai M, Gao L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156489
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156489
Cornua cervi degelatinatum inhibits breast cancer stem-like cell properties and metastasis via miR-148a-3p-mediated TGF-β/Smad2 pathway.
Ma Y, Song B, Peng J, Wei F, Hao Y, Wen Y, Lv H, Shi X, Wang Y, Peng T
Journal of ethnopharmacology 2025 Apr 25;346:119709
Journal of ethnopharmacology 2025 Apr 25;346:119709
Autophagy inhibition enhances antifibrotic potential of placental mesenchymal stem cells of fetal origin via regulating TGF-β1 mediated protein degradation of HGF.
Zhou W, Wang J, Ding L, Cai R, Cheng J, Liang P, Zhu Y, Zhang Z
Scientific reports 2025 Apr 21;15(1):13805
Scientific reports 2025 Apr 21;15(1):13805
Astragaloside I from Astragalus Attenuates Diabetic Kidney Disease by Regulating HDAC3/Klotho/TGF-β1 Loop.
Zhang X, Wang J, Xiang S, Zhao L, Lv M, Duan Y, Gao G, Wang P, Jie Chen J, Xu J, Xie Z, Zhang Z
The American journal of Chinese medicine 2024;52(6):1795-1817
The American journal of Chinese medicine 2024;52(6):1795-1817
Combination of Pirfenidone and Andrographolide Ameliorates Hepatic Stellate Cell Activation and Liver Fibrosis by Mediating TGF-β/Smad Signaling Pathway.
Xu G, Ma T, Zhou C, Zhao F, Peng K, Li B
Analytical cellular pathology (Amsterdam) 2024;2024:2751280
Analytical cellular pathology (Amsterdam) 2024;2024:2751280
Hypoxia-driven TNS4 fosters HNSCC tumorigenesis by stabilizing integrin α5β1 complex and triggering FAK-mediated Akt and TGFβ signaling pathways.
Zhao X, Mai Z, Liu L, Lu Y, Cui L, Yu J
International journal of biological sciences 2024;20(1):231-248
International journal of biological sciences 2024;20(1):231-248
Therapeutic Effects of Qingchang Tongluo Decoction on Intestinal Fibrosis in Crohn's Disease: Network Pharmacology, Molecular Docking and Experiment Validation.
Li Y, Hu J, Au R, Cheng C, Xu F, Li W, Wu Y, Cui Y, Zhu L, Shen H
Drug design, development and therapy 2024;18:3269-3293
Drug design, development and therapy 2024;18:3269-3293
FATP5 modulates biological activity and lipid metabolism in prostate cancer through the TEAD4-mediated Hippo signaling.
Liu S, He Y, Gu Z
Frontiers in oncology 2024;14:1442911
Frontiers in oncology 2024;14:1442911
Mechanism of Zhenwu Decoction modulating TLR4/NF-κB/HIF-1α loop through miR-451 to delay renal fibrosis in type 2 CRS.
Xu X, Wang Y, Song Q, Zheng H, Lv J, Fu Z, Mao X, Li Y, Wu H, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155632
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155632
Activin E upregulates uncoupling protein 1 and fibroblast growth factor 21 in brown adipocytes.
Sakaki M, Kamatari Y, Kurisaki A, Funaba M, Hashimoto O
Molecular and cellular endocrinology 2024 Oct 1;592:112326
Molecular and cellular endocrinology 2024 Oct 1;592:112326
Macrophage exosomal miR-30c-2-3p in atherosclerotic plaques aggravates microglial neuroinflammation during large-artery atherosclerotic stroke via TGF-β/SMAD2 pathway.
Tang Y, Dong MH, Pang XW, Zhang H, Chu YH, Zhou LQ, Yang S, Zhang LY, You YF, Zhu LF, Wang W, Qin C, Tian DS
Journal of neuroinflammation 2024 Nov 8;21(1):292
Journal of neuroinflammation 2024 Nov 8;21(1):292
Strategies for arterial graft optimization at the single-cell level.
Hu Z, Dai M, Chang Y, Hua X, Zhang N, Chen X, Sheng Y, Xu Z, Zhang H, Zhang Y, Cui H, Jia H, Wang XJ, Song J
Nature cardiovascular research 2024 May;3(5):541-557
Nature cardiovascular research 2024 May;3(5):541-557
The circadian clock gene, BMAL1, promotes radiosensitization in nasopharyngeal carcinoma by inhibiting the epithelial-to-mesenchymal transition via the TGF-β1/Smads/Snail1 axis.
Li Y, Zhou Y, Zhao C, Liu L, He Q, Shang K, Xu X, Luo X, Zhou D, Jin F
Oral oncology 2024 May;152:106798
Oral oncology 2024 May;152:106798
Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways.
Jiang XX, Zhang R, Wang HS
Aging 2024 May 21;16(10):8630-8644
Aging 2024 May 21;16(10):8630-8644
Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Chen J, Zhang Z, Feng L, Liu W, Wang X, Chen H, Zou H
Archives of biochemistry and biophysics 2024 Mar;753:109892
Archives of biochemistry and biophysics 2024 Mar;753:109892
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Yuan Q, Fang Y, Guo J, Zhang Z, Liao J, Kuang J
Toxicology and applied pharmacology 2024 Mar;484:116845
Toxicology and applied pharmacology 2024 Mar;484:116845
The miR-3074/BMP7 axis regulates TGF-β-caused activation of hepatic stellate cells in vitro and CCl(4)-caused murine liver fibrosis in vivo.
Liu B, Xie X, Yang X, Dou C, Tang H, Liu J
Human cell 2024 Mar;37(2):435-450
Human cell 2024 Mar;37(2):435-450
Ginsenoside RH4 inhibits Ang II-induced myocardial remodeling by interfering with NFIL3.
Wang Y, An X, Wang F, Jiang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116253
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116253
BATF promotes extramedullary infiltration through TGF-β1/Smad/MMPs axis in acute myeloid leukemia.
Zhang R, Miao J, Zhai M, Liu R, Li F, Xu X, Huang L, Wang T, Yang R, Yang R, Wang Y, He A, Wang J
Molecular carcinogenesis 2024 Jun;63(6):1146-1159
Molecular carcinogenesis 2024 Jun;63(6):1146-1159
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
Qiu T, Hou K, Zhang J, Wang N, Yao X, Yang G, Jiang L, Dong J, Miao M, Bai J, Sun X
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
Guo L, Li K, Ma Y, Niu H, Li J, Shao X, Li N, Sun Y, Wang H
Human cell 2024 Jul;37(4):972-985
Human cell 2024 Jul;37(4):972-985
Chitosan-modified dihydromyricetin liposomes promote the repair of liver injury in mice suffering from diabetes mellitus.
Ding Q, Liu X, Zhang S, Chai G, Ma S, Sun S, Shen L, Gao Y, Ding C, Zhao T, Liu W
International journal of biological macromolecules 2024 Jul;273(Pt 2):133040
International journal of biological macromolecules 2024 Jul;273(Pt 2):133040
Differentiation of Uc-MSCs into insulin secreting islet-like clusters by trypsin through TGF-beta signaling pathway.
Huang F, Lai J, Qian L, Hong W, Li LC
Differentiation; research in biological diversity 2024 Jan-Feb;135:100744
Differentiation; research in biological diversity 2024 Jan-Feb;135:100744
MET exon 14 skipping mutation drives cancer progression and recurrence via activation of SMAD2 signalling.
Liang Q, Hu Y, Yuan Q, Yu M, Wang H, Zhao B
British journal of cancer 2024 Feb;130(3):380-393
British journal of cancer 2024 Feb;130(3):380-393
HDAC6-selective inhibitor CAY10603 ameliorates cigarette smoke-induced small airway remodeling by regulating epithelial barrier dysfunction and reversing.
Zhang Q, Yan L, Lu Y, Liu X, Yin Y, Wang Q, Gu X, Zhou X
Respiratory research 2024 Feb 5;25(1):66
Respiratory research 2024 Feb 5;25(1):66
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution.
Adzraku SY, Cao C, Zhou Q, Yuan K, Hao X, Li Y, Yuan S, Huang Y, Xu K, Qiao J, Ju W, Zeng L
Cell death & disease 2024 Feb 21;15(2):159
Cell death & disease 2024 Feb 21;15(2):159
Icariin Regulates EMT and Stem Cell-Like Character in Breast Cancer through Modulating lncRNA NEAT1/TGFβ/SMAD2 Signaling Pathway.
Song B, Wei F, Peng J, Wei X, Liu M, Nie Z, Ma Y, Peng T
Biological & pharmaceutical bulletin 2024 Feb 10;47(2):399-410
Biological & pharmaceutical bulletin 2024 Feb 10;47(2):399-410
miR-134-3p Regulates Cell Proliferation and Apoptosis by Targeting INHBA via Inhibiting the TGF-β/PI3K/AKT Pathway in Sheep Granulosa Cells.
Huang X, Bao Y, Yang F, Li X, Wang F, Zhang C
Biology 2024 Dec 30;14(1)
Biology 2024 Dec 30;14(1)
Vaspin facilitates the proliferation and osteogenic differentiation of periodontal ligament stem cells.
Jing Z, Feng X, Li X, Zhang X, Pan C
Journal of periodontal research 2024 Aug;59(4):812-820
Journal of periodontal research 2024 Aug;59(4):812-820
SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress.
Ren J, Che Y, Li H, Gao H, Wang Y, Wang Y, Su H, Li Z, Li J, Qu P
Cellular and molecular life sciences : CMLS 2024 Aug 19;81(1):359
Cellular and molecular life sciences : CMLS 2024 Aug 19;81(1):359
Knockdown of long noncoding RNA AL161431.1 inhibits malignant progression of cholangiocarcinoma.
Bai Z, Tian N, Ding Z, Lu Q, Wang Y, Du S, Hui Y
Aging 2024 Aug 1;16(15):11501-11512
Aging 2024 Aug 1;16(15):11501-11512
Herb pair of Rhubarb-Astragalus mitigates renal interstitial fibrosis through downregulation of autophagy via p38-MAPK/TGF-β1 and p38-MAPK/smad2/3 pathways.
Li J, Qin X, Xu W, Zhang H, Huang S, Yang Y, Qin M, Mi Z, Zhong X
The international journal of biochemistry & cell biology 2024 Apr;169:106549
The international journal of biochemistry & cell biology 2024 Apr;169:106549
N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1.
Li J, Xu X, Xu K, Zhou X, Wu K, Yao Y, Liu Z, Chen C, Wang L, Sun Z, Jiao D, Han X
Journal of experimental & clinical cancer research : CR 2024 Apr 20;43(1):119
Journal of experimental & clinical cancer research : CR 2024 Apr 20;43(1):119
The NF-κB/NUAK2 signaling axis regulates pancreatic cancer progression by targeting SMAD2/3.
Wang R, Su D, Liu Y, Huang H, Qiu J, Cao Z, Yang G, Chen H, Luo W, Tao J, Weng G, Zhang T
iScience 2024 Apr 19;27(4):109406
iScience 2024 Apr 19;27(4):109406
Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling.
Liu G, Li M, Zeng Z, Fan Q, Ren X, Wang Z, Sun Y, He Y, Sun L, Deng Y, Liu S, Zhong C, Gao J
European journal of medical research 2024 Apr 12;29(1):228
European journal of medical research 2024 Apr 12;29(1):228
Total alkaloids of bulbus of Fritillaria cirrhosa alleviate bleomycin-induced inflammation and pulmonary fibrosis in rats by inhibiting TGF-β and NF-κB signaling pathway.
Pai M, Er-Bu A, Wu Y, Ming TW, Gaun TKW, Ye B
Food & nutrition research 2023;67
Food & nutrition research 2023;67
Identification and Characterization of a Novel Nanobody Against Human CTGF to Reveal Its Antifibrotic Effect in an in vitro Model of Liver Fibrosis.
Liu R, Zhu M, Chen J, Gai J, Huang J, Zhou Y, Wan Y, Tu C
International journal of nanomedicine 2023;18:5407-5422
International journal of nanomedicine 2023;18:5407-5422
Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α.
Zhao Z, Liu L, Chen H, Li S, Guo Y, Hou X, Yang J
Frontiers in pharmacology 2023;14:1138265
Frontiers in pharmacology 2023;14:1138265
IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer.
Guan XQ, Yuan XN, Feng KX, Shao YC, Liu Q, Yang ZL, Chen YY, Deng J, Hu MS, Li J, Tian YH, Chu MF, Zhang JW, Wei L
American journal of cancer research 2023;13(7):2948-2968
American journal of cancer research 2023;13(7):2948-2968
An miRNA-mRNA integrative analysis in human placentas and mice: role of the Smad2/miR-155-5p axis in the development of fetal growth restriction.
Wu JX, Shi M, Gong BM, Ji BW, Hu CC, Wang GC, Lei L, Tang C, Sun LV, Wu XH, Wang X
Frontiers in bioengineering and biotechnology 2023;11:1159805
Frontiers in bioengineering and biotechnology 2023;11:1159805
The m6A reader YTHDC1-mediated lncRNA CTBP1-AS2 m6A modification accelerates cholangiocarcinoma progression.
Jin Z, Liu Y
Heliyon 2023 Sep;9(9):e19816
Heliyon 2023 Sep;9(9):e19816
Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcoma.
Yuan J, Jia J, Wu T, Du Z, Chen Q, Zhang J, Wu Z, Yuan Z, Zhao X, Liu J, Guo J, Cheng X
Cancer cell international 2023 Sep 26;23(1):215
Cancer cell international 2023 Sep 26;23(1):215
A nano-conductive osteogenic hydrogel to locally promote calcium influx for electro-inspired bone defect regeneration.
Yu C, Ying X, Shahbazi MA, Yang L, Ma Z, Ye L, Yang W, Sun R, Gu T, Tang R, Fan S, Yao S
Biomaterials 2023 Oct;301:122266
Biomaterials 2023 Oct;301:122266
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
The hsa_circ_0004805/hsa_miR-149-5p/TGFB2 axis plays critical roles in the pathophysiology of diabetic retinopathy in vitro and in vivo.
Shao J, Gu W, Ye L, Xin Y
Molecular and cellular endocrinology 2023 Oct 1;576:112042
Molecular and cellular endocrinology 2023 Oct 1;576:112042
Yishen Tongluo formula alleviates diabetic kidney disease through regulating Sirt6/TGF-β1/Smad2/3 pathway and promoting degradation of TGF-β1.
Zhang X, Zhao L, Xiang S, Sun Y, Wang P, Chen JJ, Teo BS, Xie Z, Zhang Z, Xu J
Journal of ethnopharmacology 2023 May 10;307:116243
Journal of ethnopharmacology 2023 May 10;307:116243
Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins.
Ren HL, Zhang JH, Xiao JH
Heliyon 2023 Jun;9(6):e16849
Heliyon 2023 Jun;9(6):e16849
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
Wu JC, Wang XJ, Zhu JH, Huang XY, Liu M, Qiao Z, Zhang Y, Sun Y, Wang ZY, Zhan P, Zhang T, Hu HL, Liu H, Tang W, Yi F
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF-β/SMAD signalling.
Zhang Z, Wu W, Jiao H, Chen Y, Ji X, Cao J, Yin F, Yin W
British journal of pharmacology 2023 Jun;180(12):1562-1581
British journal of pharmacology 2023 Jun;180(12):1562-1581
Down-regulation of the Smad signaling by circZBTB46 via the Smad2-PDLIM5 axis to inhibit type I collagen expression.
Yu J, Yan WZ, Zhang XH, Zheng B, Pan WS, Yang Z, Zhang H, Nie ZY, Ma Y, Bai Y, Zhang L, Feng DD, Wen JK
Journal of geriatric cardiology : JGC 2023 Jun 28;20(6):431-447
Journal of geriatric cardiology : JGC 2023 Jun 28;20(6):431-447
Sacha inchi albumin delays skin-aging by alleviating inflammation, oxidative stress and regulating gut microbiota in d-galactose induced-aging mice.
Zeng J, An M, Tian W, Wang K, Du B, Li P
Journal of the science of food and agriculture 2023 Jul;103(9):4470-4480
Journal of the science of food and agriculture 2023 Jul;103(9):4470-4480
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Jie Li Z, Bing Luo C, Liang Wang H, Sun J, Qian Yang Q, Lang Zhou Y
International journal of pharmaceutics 2023 Jul 25;642:123190
International journal of pharmaceutics 2023 Jul 25;642:123190
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Pan C, Fei Q, Jin J, Zheng J, Wu D, Li H, Huang X, Kong X
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
The miR-103a-3p/TGFBR3 axis regulates TGF-β-induced orbital fibroblast activation and fibrosis in thyroid-eye disease.
Xie B, Xiong W, Zhang F, Wang N, Luo Y, Chen Y, Cao J, Chen Z, Ma C, Chen H
Molecular and cellular endocrinology 2023 Jan 1;559:111780
Molecular and cellular endocrinology 2023 Jan 1;559:111780
Hepatic stellate cell-released CXCL1 aggravates HCC malignant behaviors through the MIR4435-2HG/miR-506-3p/TGFB1 axis.
Li S, Hu X, Yu S, Yi P, Chen R, Huang Z, Huang Y, Huang Y, Zhou R, Fan X
Cancer science 2023 Feb;114(2):504-520
Cancer science 2023 Feb;114(2):504-520
KNTC1, regulated by HPV E7, inhibits cervical carcinogenesis partially through Smad2.
Pan W, Wang S, Liu X, Wang M, Han X, Tian X, Lin J, Qiao X, Wang X
Experimental cell research 2023 Feb 1;423(1):113458
Experimental cell research 2023 Feb 1;423(1):113458
Exosomes derived from human dermal fibroblasts protect against UVB‑induced skin photoaging.
Park AY, Lee JO, Jang Y, Kim YJ, Lee JM, Kim SY, Kim BJ, Yoo KH
International journal of molecular medicine 2023 Dec;52(6)
International journal of molecular medicine 2023 Dec;52(6)
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.
Cui L, Lu Y, Zheng J, Guo B, Zhao X
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335
Inhibition of TGF-β1-induced epithelial-mesenchymal transition in gliomas by DMC-HA.
Shi L, Wang Z, Rong J, Fei X, Li X, He B, Gong W, Qian J
Aging 2023 Dec 27;15(24):15183-15195
Aging 2023 Dec 27;15(24):15183-15195
Exosomal ITGB6 from dormant lung adenocarcinoma cells activates cancer-associated fibroblasts by KLF10 positive feedback loop and the TGF-β pathway.
Feng X, Liu X, Xiang J, Xu J, Yin N, Wang L, Liu C, Liu Y, Zhao T, Zhao Z, Gao Y
Translational lung cancer research 2023 Dec 26;12(12):2520-2537
Translational lung cancer research 2023 Dec 26;12(12):2520-2537
The chromatin remodeling protein BRG1 regulates HSC-myofibroblast differentiation and liver fibrosis.
Zhu Y, Kang A, Kuai Y, Guo Y, Miao X, Zhu L, Kong M, Li N
Cell death & disease 2023 Dec 14;14(12):826
Cell death & disease 2023 Dec 14;14(12):826
Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.
Hu Z, Zhang Y, Chen J, Luo M, Wang N, Xiao Y, He Q
Molecular and cellular biochemistry 2023 Aug;478(8):1791-1802
Molecular and cellular biochemistry 2023 Aug;478(8):1791-1802
HOXA11 promotes lymphatic metastasis of gastric cancer via transcriptional activation of TGFβ1.
Li Z, Lu T, Chen Z, Yu X, Wang L, Shen G, Huang H, Li Z, Ren Y, Guo W, Hu Y
iScience 2023 Aug 18;26(8):107346
iScience 2023 Aug 18;26(8):107346
Adipose-derived mesenchymal stem cell therapy for reverse bleomycin-induced experimental pulmonary fibrosis.
Zhao X, Wu J, Yuan R, Li Y, Yang Q, Wu B, Zhai X, Wang J, Magalon J, Sabatier F, Daumas A, Zhu WM, Zhu N
Scientific reports 2023 Aug 14;13(1):13183
Scientific reports 2023 Aug 14;13(1):13183
CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF-β/Smad signaling.
Wang QR, Liu SS, Min JL, Yin M, Zhang Y, Zhang Y, Tang XN, Li X, Liu SS
Biochemical pharmacology 2023 Apr;210:115475
Biochemical pharmacology 2023 Apr;210:115475
Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-β1/Smad Signaling.
Yang C, Xiao Y, Du Y, Xiong J, Deng L, Liang Q, Yuan J, He C, He F, Huang X
Disease markers 2022;2022:9230647
Disease markers 2022;2022:9230647
Loureirin A Exerts Antikeloid Activity by Antagonizing the TGF-β1/Smad Signalling Pathway.
Ma H, Duan X, Zhang R, Li H, Guo Y, Tian Y, Huang M, Chen G, Wang Z, Li L
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8661288
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8661288
Multifunctional Drug-Loaded Phase-Change Nanoparticles Inhibit the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Affecting the Activity of Activated Hepatic Stellate Cells.
Zou X, Li T, Mao Y, Zhu M, Chen X, Niu J, Dong T, Jiang J, Yang X
BioMed research international 2022;2022:6441179
BioMed research international 2022;2022:6441179
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Li B, Lu ZY, Jiang SD, Jiang LS, Zheng XF
Oxidative medicine and cellular longevity 2022;2022:2912276
Oxidative medicine and cellular longevity 2022;2022:2912276
Pyrrosia petiolosa Extract Ameliorates Ethylene Glycol-Induced Urolithiasis in Rats by Inhibiting Oxidative Stress and Inflammatory Response.
Zhou F, Wang X
Disease markers 2022;2022:1913067
Disease markers 2022;2022:1913067
GPC1 promotes the growth and migration of colorectal cancer cells through regulating the TGF-β1/SMAD2 signaling pathway.
Lu F, Chen S, Shi W, Su X, Wu H, Liu M
PloS one 2022;17(6):e0269094
PloS one 2022;17(6):e0269094
NR4A1 inhibits the epithelial-mesenchymal transition of hepatic stellate cells: Involvement of TGF-β-Smad2/3/4-ZEB signaling.
Huang Q, Xu J, Ge Y, Shi Y, Wang F, Zhu M
Open life sciences 2022;17(1):447-454
Open life sciences 2022;17(1):447-454
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling.
Hu H, Mao G, Zheng J, Guo F
Drug design, development and therapy 2022;16:4223-4234
Drug design, development and therapy 2022;16:4223-4234
A robust CD8(+) T cell-related classifier for predicting the prognosis and efficacy of immunotherapy in stage III lung adenocarcinoma.
Feng J, Xu L, Zhang S, Geng L, Zhang T, Yu Y, Yuan R, He Y, Nan Z, Lin M, Guo H
Frontiers in immunology 2022;13:993187
Frontiers in immunology 2022;13:993187
Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models.
Ramani K, Mavila N, Abeynayake A, Tomasi ML, Wang J, Matsuda M, Seki E
eLife 2022 Oct 4;11
eLife 2022 Oct 4;11
Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa.
Zhang X, Cao Y, Pan D, Yao X, Wang F, Zhang G, Luo Y
Phytochemistry 2022 Nov;203:113378
Phytochemistry 2022 Nov;203:113378
NCAPH regulates gastric cancer progression through DNA damage response.
Wang Y, Li JQ, Yang ZL, Wang L, Zhang JC, Sun YF, Li ZY, Qin L
Neoplasma 2022 Mar;69(2):283-291
Neoplasma 2022 Mar;69(2):283-291
Comparative analyses in transcriptome of human granulosa cells and follicular fluid micro-environment between poor ovarian responders with conventional controlled ovarian or mild ovarian stimulations.
Liu X, Mai H, Chen P, Zhang Z, Wu T, Chen J, Sun P, Zhou C, Liang X, Huang R
Reproductive biology and endocrinology : RB&E 2022 Mar 21;20(1):54
Reproductive biology and endocrinology : RB&E 2022 Mar 21;20(1):54
Long noncoding RNA Lnc-DIF inhibits bone formation by sequestering miR-489-3p.
Yin C, Tian Y, Li D, Yu Y, Jiang S, Hou Y, Deng M, Zheng K, Zhang Y, Deng X, Chen Z, Miao Z, Hao Q, Li Y, Qian A
iScience 2022 Mar 18;25(3):103949
iScience 2022 Mar 18;25(3):103949
The Novel Competing Endogenous Long Noncoding RNA SM2 Regulates Gonadotropin Secretion in the Hu Sheep Anterior Pituitary by Targeting the Oar-miR-16b/TGF-β/SMAD2 Signaling Pathway.
Wan Z, Yang H, Chen P, Wang Z, Cai Y, Yao X, Wang F, Zhang Y
Cells 2022 Mar 14;11(6)
Cells 2022 Mar 14;11(6)
Adiponectin Alleviates Intestinal Fibrosis by Enhancing AMP-Activated Protein Kinase Phosphorylation.
Xie M, Xiong Z, Yin S, Xiong J, Li X, Jin L, Zhang F, Chen H, Lan P, Lian L
Digestive diseases and sciences 2022 Jun;67(6):2232-2243
Digestive diseases and sciences 2022 Jun;67(6):2232-2243
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Wan Q, Zhang L, Zhou Q, Han Y, Li Z, Li B
Inflammation 2022 Jun;45(3):1039-1058
Inflammation 2022 Jun;45(3):1039-1058
Gli(ko) BMSC: A potential strategy of treatment for renal fibrosis.
Shi L, Gao X, Bi Y, Li M, Sun H, Tian X, Bi W
Regenerative therapy 2022 Jun;20:157-164
Regenerative therapy 2022 Jun;20:157-164
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
Wu L, Yang FR, Xing ML, Lu SF, Chen HL, Yang QW, Zhang YT, Lu Y, Huang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154055
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154055
A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer.
Xu X, Wang H, Li X, Duan X, Wang Y
Aging 2022 Jun 9;14(11):4858-4873
Aging 2022 Jun 9;14(11):4858-4873
Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice.
Jiang J, Ding S, Zhang G, Dong Y
Ecotoxicology and environmental safety 2022 Jun 15;238:113571
Ecotoxicology and environmental safety 2022 Jun 15;238:113571
Hyperglycemia induces miR-26-5p down-regulation to overexpress PFKFB3 and accelerate epithelial-mesenchymal transition in gastric cancer.
He X, Cheng X, Ding J, Xiong M, Chen B, Cao G
Bioengineered 2022 Feb;13(2):2902-2917
Bioengineered 2022 Feb;13(2):2902-2917
Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway.
Wang H, Jiang Q, Zhang L
Pharmaceutical biology 2022 Dec;60(1):1407-1416
Pharmaceutical biology 2022 Dec;60(1):1407-1416
CeO(2) nanoparticles induce pulmonary fibrosis via activating S1P pathway as revealed by metabolomics.
Cui L, Wang X, Zhao X, Sun B, Xia T, Hu S
Nano today 2022 Aug;45
Nano today 2022 Aug;45
Extracellular HSP90α promotes cellular senescence by modulating TGF-β signaling in pulmonary fibrosis.
Zhong W, Chen W, Liu Y, Zhang J, Lu Y, Wan X, Qiao Y, Huang H, Zeng Z, Li W, Meng X, Zhao H, Zou M, Cai S, Dong H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22475
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22475
Botox-A improve the thyroid-associated ophthalmopathy (TAO) orbital fibroblast activation through inhibiting the TGF-β/Smad signaling.
Qi X, Luo B, Deng M, Cao J, Hou S, Xie Z, Tong B, Xiong W
Experimental eye research 2022 Apr;217:108971
Experimental eye research 2022 Apr;217:108971
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Liu Z, Xu B, Ding Y, Ding X, Yang Z
Bioengineered 2022 Apr;13(4):9357-9368
Bioengineered 2022 Apr;13(4):9357-9368
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Zhang Z, Chen B, Zhu Y, Zhang T, Zhang X, Yuan Y, Xu Y
Frontiers in cell and developmental biology 2021;9:664375
Frontiers in cell and developmental biology 2021;9:664375
Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.
Liu Y, Zhong W, Zhang J, Chen W, Lu Y, Qiao Y, Zeng Z, Huang H, Cai S, Dong H
Frontiers in pharmacology 2021;12:739220
Frontiers in pharmacology 2021;12:739220
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Pan J, Cao Z, Fang C, Lei Y, Sun J, Huang X, Han D
Frontiers in pharmacology 2021;12:722530
Frontiers in pharmacology 2021;12:722530
Elevated IgE promotes cardiac fibrosis by suppressing miR-486a-5p.
Zhao H, Yang H, Geng C, Chen Y, Tang Y, Li Z, Pang J, Shu T, Nie Y, Liu Y, Jia K, Wang J
Theranostics 2021;11(15):7600-7615
Theranostics 2021;11(15):7600-7615
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Ni K, Huang Z, Zhu Y, Xue D, Jin Q, Zhang C, Gu C
Frontiers in oncology 2021;11:654472
Frontiers in oncology 2021;11:654472
Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro.
Lv W, Ren Y, Wu M, Luo X, Yu J, Zhang Q, Wu Y
Burns : journal of the International Society for Burn Injuries 2021 Sep;47(6):1359-1372
Burns : journal of the International Society for Burn Injuries 2021 Sep;47(6):1359-1372
Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling.
Zhao W, Zhang X, Hou M, Zhang Y, Tang Y, Li L, Dong S, Liu L, Zhao D, Li W, Nan Y
Histology and histopathology 2021 Sep;36(9):967-979
Histology and histopathology 2021 Sep;36(9):967-979
Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway.
Li S, Gan L, Tian YJ, Tian Y, Fan RZ, Huang D, Yuan FY, Zhang X, Lin Y, Zhu QF, Tang GH, Yan XL, Yin S
Bioorganic chemistry 2021 Sep;114:105222
Bioorganic chemistry 2021 Sep;114:105222
The miR-182/Myadm axis regulates hypoxia-induced pulmonary hypertension by balancing the BMP- and TGF-β-signalling pathways in an SMC/EC-crosstalk-associated manner.
Bai Y, Wang J, Chen Y, Lv T, Wang X, Liu C, Xue H, He K, Sun L
Basic research in cardiology 2021 Sep 21;116(1):53
Basic research in cardiology 2021 Sep 21;116(1):53
Bergenin attenuates bleomycin-induced pulmonary fibrosis in mice via inhibiting TGF-β1 signaling pathway.
Li X, Wang Y, Liang J, Bi Z, Ruan H, Cui Y, Ma L, Wei Y, Zhou B, Zhang L, Zhou H, Yang C
Phytotherapy research : PTR 2021 Oct;35(10):5808-5822
Phytotherapy research : PTR 2021 Oct;35(10):5808-5822
SMAD2 regulates testicular development and testosterone synthesis in Hu sheep.
Yang H, Wan Z, Jin Y, Wang F, Zhang Y
Theriogenology 2021 Oct 15;174:139-148
Theriogenology 2021 Oct 15;174:139-148
An experimental model of the epithelial to mesenchymal transition and pro-fibrogenesis in urothelial cells related to bladder pain syndrome/interstitial cystitis.
Jin XW, Wang QZ, Zhao Y, Liu BK, Zhang X, Wang XJ, Lu GL, Pan JW, Shao Y
Translational andrology and urology 2021 Nov;10(11):4120-4131
Translational andrology and urology 2021 Nov;10(11):4120-4131
Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway.
Xiao Y, Deng J, Li C, Gong X, Gui Z, Huang J, Zhang Y, Liu Y, Ye X, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153488
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153488
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Zhao B, Li S, Guo Z, Chen Z, Zhang X, Xu C, Chen J, Wei C
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-β1/Smad pathway.
Zheng M, Li H, Sun L, Brigstock DR, Gao R
Cytokine 2021 Jul;143:155536
Cytokine 2021 Jul;143:155536
Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells (HSCs) in vitro and CCl(4)-induced hepatic fibrosis in rats in vivo.
Wang R, Zhang D, Tang D, Sun K, Peng J, Zhu W, Yin S, Wu Y
International immunopharmacology 2021 Jan;90:107151
International immunopharmacology 2021 Jan;90:107151
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
Wang R, Wu G, Dai T, Lang Y, Chi Z, Yang S, Dong D
Experimental and therapeutic medicine 2021 Jan;21(1):66
Experimental and therapeutic medicine 2021 Jan;21(1):66
ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.
Ma L, Li C, Lian S, Xu B, Yuan J, Lu J, Yang H, Guo J, Ji H
Molecular and cellular endocrinology 2021 Jan 1;519:111055
Molecular and cellular endocrinology 2021 Jan 1;519:111055
PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis.
Yu Q, Cheng P, Wu J, Guo C
Journal of cellular and molecular medicine 2021 Feb;25(3):1645-1660
Journal of cellular and molecular medicine 2021 Feb;25(3):1645-1660
SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion.
Yang S, Zhang H, Yang H, Zhang J, Wang J, Luo T, Jiang Y, Hua H
Experimental hematology & oncology 2021 Feb 23;10(1):17
Experimental hematology & oncology 2021 Feb 23;10(1):17
Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions.
Chen X, Zhang Y, Qian W, Han L, Li W, Duan W, Wu Z, Wang Z, Ma Q
iScience 2021 Dec 17;24(12):103400
iScience 2021 Dec 17;24(12):103400
MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein.
Zhuang Y, Li X, Zhan P, Pi G, Wen G
Oncology reports 2021 Apr;45(4)
Oncology reports 2021 Apr;45(4)
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Xiao Y, Liu Y, Lai Z, Huang J, Li C, Zhang Y, Gong X, Deng J, Ye X, Li X
Journal of ethnopharmacology 2021 Apr 24;270:113806
Journal of ethnopharmacology 2021 Apr 24;270:113806
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, Chi T, Zou L, Wang S, He Z
Oxidative medicine and cellular longevity 2020;2020:7950457
Oxidative medicine and cellular longevity 2020;2020:7950457
USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2.
Dou N, Hu Q, Li L, Wu Q, Li Y, Gao Y
International journal of biological sciences 2020;16(9):1648-1657
International journal of biological sciences 2020;16(9):1648-1657
Ligand-independent EphB1 signaling mediates TGF-β-activated CDH2 and promotes lung cancer cell invasion and migration.
Wang L, Peng Q, Sai B, Zheng L, Xu J, Yin N, Feng X, Xiang J
Journal of Cancer 2020;11(14):4123-4131
Journal of Cancer 2020;11(14):4123-4131
Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway.
Li X, Leng Y, Jiang Q, Wang Z, Luo P, Zhang C, Chen L, Wang Y, Wang H, Yue X, Shen C, Zhou Y, Shi C, Xie L
Frontiers in pharmacology 2020;11:1038
Frontiers in pharmacology 2020;11:1038
KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway.
Li Y, Yang J, Zhang X, Liu H, Guo J
Experimental and therapeutic medicine 2020 Sep;20(3):2774-2782
Experimental and therapeutic medicine 2020 Sep;20(3):2774-2782
Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing.
Jiang L, Zhang Y, Liu T, Wang X, Wang H, Song H, Wang W
Biochimie 2020 Oct;177:40-49
Biochimie 2020 Oct;177:40-49
TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis.
Xu S, Mao Y, Wu J, Feng J, Li J, Wu L, Yu Q, Zhou Y, Zhang J, Chen J, Ji J, Chen K, Wang F, Dai W, Fan X, Guo C
Journal of cellular and molecular medicine 2020 May;24(9):5224-5237
Journal of cellular and molecular medicine 2020 May;24(9):5224-5237
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
Su C, Wang Q, Luo H, Jiao W, Tang J, Li L, Tian L, Chen X, Liu B, Yu X, Li S, Guo S, Wang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma.
Zheng S, Wan L, Ge D, Jiang F, Qian Z, Tang J, Yang J, Yao Y, Yan J, Zhao L, Li H, Yang L
Cell death & disease 2020 Jul 24;11(7):576
Cell death & disease 2020 Jul 24;11(7):576
Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-β signals.
Fan P, Li Z, Zuo C, Fang M
Cell biochemistry and function 2020 Jan;38(1):38-46
Cell biochemistry and function 2020 Jan;38(1):38-46
Raw and vinegar processed Curcuma wenyujin regulates hepatic fibrosis via bloking TGF-β/Smad signaling pathways and up-regulation of MMP-2/TIMP-1 ratio.
Xie H, Su D, Zhang J, Ji D, Mao J, Hao M, Wang Q, Yu M, Mao C, Lu T
Journal of ethnopharmacology 2020 Jan 10;246:111768
Journal of ethnopharmacology 2020 Jan 10;246:111768
Retinal pigment epithelial cells secrete miR-202-5p-containing exosomes to protect against proliferative diabetic retinopathy.
Gu S, Liu Y, Zou J, Wang W, Wei T, Wang X, Zhu L, Zhang M, Zhu J, Xie T, Yao Y, Qiu L
Experimental eye research 2020 Dec;201:108271
Experimental eye research 2020 Dec;201:108271
miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling.
Xu P, Li Z, Wang Y, Yu X, Shao X, Li YX, Peng C, Zhao Y, Wang YL
Molecular therapy. Nucleic acids 2020 Dec 4;22:542-556
Molecular therapy. Nucleic acids 2020 Dec 4;22:542-556
LncRNA Gm16410 regulates PM(2.5)-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway.
Ma K, Li C, Xu J, Ren F, Xu X, Liu C, Niu B, Li F
Ecotoxicology and environmental safety 2020 Dec 1;205:111327
Ecotoxicology and environmental safety 2020 Dec 1;205:111327
MicroRNA-148a-3p inhibits progression of hepatocelluar carcimoma by repressing SMAD2 expression in an Ago2 dependent manner.
Huang Z, Wen J, Yu J, Liao J, Liu S, Cai N, Liang H, Chen X, Ding Z, Zhang B
Journal of experimental & clinical cancer research : CR 2020 Aug 4;39(1):150
Journal of experimental & clinical cancer research : CR 2020 Aug 4;39(1):150
Inhibitory Effect of Corilagin on miR-21-Regulated Hepatic Fibrosis Signaling Pathway.
Zhou X, Xiong J, Lu S, Luo L, Chen ZL, Yang F, Jin F, Wang Y, Ma Q, Luo YY, Wang YJ, Zhou JB, Liu P, Zhao L
The American journal of Chinese medicine 2019;47(7):1541-1569
The American journal of Chinese medicine 2019;47(7):1541-1569
A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway.
Tran BH, Yu Y, Chang L, Tan B, Jia W, Xiong Y, Dai T, Zhong R, Zhang W, Le VM, Rose P, Wang Z, Mao Y, Zhu YZ
International journal of nanomedicine 2019;14:10061-10077
International journal of nanomedicine 2019;14:10061-10077
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
Shao Q, Jiang C, Xia Y, Zhao M, Zhang Q, Jin B, Liu J
International journal of clinical and experimental pathology 2019;12(3):867-875
International journal of clinical and experimental pathology 2019;12(3):867-875
POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.
Wang B, Xu X, Yang Z, Zhang L, Liu Y, Ma A, Xu G, Tang M, Jing T, Wu L, Liu Y
EBioMedicine 2019 Mar;41:320-332
EBioMedicine 2019 Mar;41:320-332
MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer.
He W, Liang B, Wang C, Li S, Zhao Y, Huang Q, Liu Z, Yao Z, Wu Q, Liao W, Zhang S, Liu Y, Xiang Y, Liu J, Shi M
Oncogene 2019 Jun;38(23):4637-4654
Oncogene 2019 Jun;38(23):4637-4654
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Xue K, Zhang J, Li C, Li J, Wang C, Zhang Q, Chen X, Yu X, Sun L, Yu X
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
Platelets promote invasion and induce epithelial to mesenchymal transition in ovarian cancer cells by TGF-β signaling pathway.
Guo Y, Cui W, Pei Y, Xu D
Gynecologic oncology 2019 Jun;153(3):639-650
Gynecologic oncology 2019 Jun;153(3):639-650
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
Yuan J, Tan L, Yin Z, Zhu W, Tao K, Wang G, Shi W, Gao J
Cell death & disease 2019 Jun 11;10(6):454
Cell death & disease 2019 Jun 11;10(6):454
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
Hu B, Mao Z, Du Q, Jiang X, Wang Z, Xiao Z, Zhu D, Wang X, Zhu Y, Wang H
Brain research bulletin 2019 Jul;149:21-31
Brain research bulletin 2019 Jul;149:21-31
HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways.
Lei R, Li J, Liu F, Li W, Zhang S, Wang Y, Chu X, Xu J
Cell cycle (Georgetown, Tex.) 2019 Dec;18(23):3239-3250
Cell cycle (Georgetown, Tex.) 2019 Dec;18(23):3239-3250
LRG1 Promotes Apoptosis and Autophagy through the TGFβ-smad1/5 Signaling Pathway to Exacerbate Ischemia/Reperfusion Injury.
Jin J, Sun H, Liu D, Wang H, Liu Q, Chen H, Zhong D, Li G
Neuroscience 2019 Aug 10;413:123-134
Neuroscience 2019 Aug 10;413:123-134
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
Zhao J, Meng M, Zhang J, Li L, Zhu X, Zhang L, Wang C, Gao M
Molecular medicine reports 2019 Apr;19(4):3168-3178
Molecular medicine reports 2019 Apr;19(4):3168-3178
A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma.
Lewis DM, Pruitt H, Jain N, Ciccaglione M, McCaffery JM, Xia Z, Weber K, Eisinger-Mathason TSK, Gerecht S
Cancer research 2019 Apr 15;79(8):1981-1995
Cancer research 2019 Apr 15;79(8):1981-1995
Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway.
Ye X, He L, Ma J, Li Y, Zhang M, Yang J, Zhang J, Xiao F, Wei H
Molecular medicine reports 2018 Oct;18(4):3611-3618
Molecular medicine reports 2018 Oct;18(4):3611-3618
Role of TGF-β1/Smad3-mediated fibrosis in drug resistance mechanism of prolactinoma.
Hu B, Mao Z, Jiang X, He D, Wang Z, Wang X, Zhu Y, Wang H
Brain research 2018 Nov 1;1698:204-212
Brain research 2018 Nov 1;1698:204-212
MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.
Li J, Zou K, Yu L, Zhao W, Lu Y, Mao J, Wang B, Wang L, Fan S, Song B, Li L
Molecular therapy. Nucleic acids 2018 Mar 2;10:426-437
Molecular therapy. Nucleic acids 2018 Mar 2;10:426-437
PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.
Zhao B, Liu L, Mao J, Zhang Z, Wang Q, Li Q
Cell death & disease 2018 Feb 22;9(3):307
Cell death & disease 2018 Feb 22;9(3):307
Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway.
Xiao Y, Ye J, Zhou Y, Huang J, Liu X, Huang B, Zhu L, Wu B, Zhang G, Cai Y
Archives of biochemistry and biophysics 2018 Feb 15;640:37-46
Archives of biochemistry and biophysics 2018 Feb 15;640:37-46
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
Wang EM, Fan QL, Yue Y, Xu L
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.
Yan L, You WQ, Sheng NQ, Gong JF, Hu LD, Tan GW, Chen HQ, Wang ZG
Aging 2018 Dec 6;10(12):3774-3793
Aging 2018 Dec 6;10(12):3774-3793
Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization.
Lu H, Wu L, Liu L, Ruan Q, Zhang X, Hong W, Wu S, Jin G, Bai Y
Biochemical pharmacology 2018 Aug;154:203-212
Biochemical pharmacology 2018 Aug;154:203-212
Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients.
Deng WL, Gao ML, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY, Chen YC, Li YP, Pan D, Xue T, Jin ZB
Stem cell reports 2018 Apr 10;10(4):1267-1281
Stem cell reports 2018 Apr 10;10(4):1267-1281
High doses of baicalin induces kidney injury and fibrosis through regulating TGF-β/Smad signaling pathway.
Cai Y, Ma W, Xiao Y, Wu B, Li X, Liu F, Qiu J, Zhang G
Toxicology and applied pharmacology 2017 Oct 15;333:1-9
Toxicology and applied pharmacology 2017 Oct 15;333:1-9
Transforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling.
Zhang X, Fan Q, Li Y, Yang Z, Yang L, Zong Z, Wang B, Meng X, Li Q, Liu J, Li H
Oncotarget 2017 May 2;8(18):29785-29794
Oncotarget 2017 May 2;8(18):29785-29794
Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop.
Lei K, Liang X, Gao Y, Xu B, Xu Y, Li Y, Tao Y, Shi W, Liu J
Biochemical and biophysical research communications 2017 Mar 11;484(3):514-521
Biochemical and biophysical research communications 2017 Mar 11;484(3):514-521
Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer.
Xiang J, Fu X, Ran W, Wang Z
Oncogenesis 2017 Jan 9;6(1):e284
Oncogenesis 2017 Jan 9;6(1):e284
Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.
Zhao B, Liu L, Mao J, Liu K, Fan W, Liu J, Zhang Z, Li Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1036-1044
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1036-1044
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy.
Yan N, Wen L, Peng R, Li H, Liu H, Peng H, Sun Y, Wu T, Chen L, Duan Q, Sun Y, Zhou Q, Wei L, Zhang Z
Journal of diabetes research 2016;2016:8738760
Journal of diabetes research 2016;2016:8738760
Metformin alleviates vascular calcification induced by vitamin D3 plus nicotine in rats via the AMPK pathway.
Zhang X, Xiao J, Li R, Qin X, Wang F, Mao Y, Liang W, Sheng X, Guo M, Song Y, Ji X
Vascular pharmacology 2016 Jun;81:83-90
Vascular pharmacology 2016 Jun;81:83-90
In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse.
Chen X, Kong X, Liu D, Gao P, Zhang Y, Li P, Liu M
International journal of molecular medicine 2016 Jul;38(1):95-104
International journal of molecular medicine 2016 Jul;38(1):95-104
Phenylethanol Glycosides from Cistanche tubulosa Suppress Hepatic Stellate Cell Activation and Block the Conduction of Signaling Pathways in TGF-β1/smad as Potential Anti-Hepatic Fibrosis Agents.
You SP, Ma L, Zhao J, Zhang SL, Liu T
Molecules (Basel, Switzerland) 2016 Jan 18;21(1):102
Molecules (Basel, Switzerland) 2016 Jan 18;21(1):102
Interplay between intergrin-linked kinase and ribonuclease inhibitor affects growth and metastasis of bladder cancer through signaling ILK pathways.
Zhuang X, Lv M, Zhong Z, Zhang L, Jiang R, Chen J
Journal of experimental & clinical cancer research : CR 2016 Aug 30;35(1):130
Journal of experimental & clinical cancer research : CR 2016 Aug 30;35(1):130
Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice.
Chen MS, Zhang JH, Wang JL, Gao L, Chen XX, Xiao JH
The American journal of Chinese medicine 2015;43(2):231-40
The American journal of Chinese medicine 2015;43(2):231-40
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Dong D, Yin L, Qi Y, Xu L, Peng J
Nutrients 2015 Jun 15;7(6):4829-50
Nutrients 2015 Jun 15;7(6):4829-50
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy.
Shen M, Chen K, Lu J, Cheng P, Xu L, Dai W, Wang F, He L, Zhang Y, Chengfen W, Li J, Yang J, Zhu R, Zhang H, Zheng Y, Zhou Y, Guo C
Mediators of inflammation 2014;2014:954502
Mediators of inflammation 2014;2014:954502
TGF-β2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF.
Ma B, Kang Q, Qin L, Cui L, Pei C
Biochemical and biophysical research communications 2014 May 16;447(4):689-95
Biochemical and biophysical research communications 2014 May 16;447(4):689-95
The role of SIRT6 in the differentiation of vascular smooth muscle cells in response to cyclic strain.
Yao QP, Zhang P, Qi YX, Chen SG, Shen BR, Han Y, Yan ZQ, Jiang ZL
The international journal of biochemistry & cell biology 2014 Apr;49:98-104
The international journal of biochemistry & cell biology 2014 Apr;49:98-104
Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice.
Zhang XY, Shen BR, Zhang YC, Wan XJ, Yao QP, Wu GL, Wang JY, Chen SG, Yan ZQ, Jiang ZL
PloS one 2013;8(3):e59002
PloS one 2013;8(3):e59002
Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis.
Wang Z, Liu F, Tu W, Chang Y, Yao J, Wu W, Jiang X, He X, Lin J, Song Y
Journal of cellular and molecular medicine 2012 Jan;16(1):118-28
Journal of cellular and molecular medicine 2012 Jan;16(1):118-28
Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease.
Zhang Y, Fei M, Xue G, Zhou Q, Jia Y, Li L, Xin H, Sun S
Journal of cellular and molecular medicine 2012 Feb;16(2):249-59
Journal of cellular and molecular medicine 2012 Feb;16(2):249-59
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 12570-1-AP(SMAD2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using SMAD2 antibody 12570-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human endometrial cancer using 12570-1-AP(SMAD2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
