Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations [0]
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- Product number
- 80427-2-RR - Provider product page

- Provider
- Proteintech Group
- Product name
- Phospho-SMAD2 (Ser465/467)/SMAD3 (Ser423/425) monoclonal antibody
- Antibody type
- Recombinant
- Description
- Phospho-SMAD2 (Ser465/467)/SMAD3 (Ser423/425) monoclonal antibody (Catalog no. 80427-2-RR) is a rabbit recombinant antibody that shows reactivity with human and has been validated for the following applications: WB, IF/ICC, FC (Intra), ELISA, ChIP-qPCR
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 240826D11
Submitted references Bisdemethoxycurcumin attenuates myocardial fibrosis in heart failure with preserved ejection fraction by targeting TGFBR1 and oxidative stress.
Huanggan decoction ameliorates cholestatic hepatic fibrosis in rats via TGF-β1/Smad3 signaling pathway.
Mechanism of Platelet-Rich Plasma in Promoting Diabetic Wound Healing via the PI3K/AKT Signaling Pathway to Regulate Collagen Synthesis and Angiogenesis.
YTHDF2 promotes arsenic carcinogenesis through m(6)A-dependent SMAD7 decay and PRR5 escape from decay.
A Brain-Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF-β1/PI3K-AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses.
CD14+ Monocytes Will Become a New Target for the Treatment of Osteoporosis: Based on Mendel Randomization, Clinical Analysis and Cell Experiment Verification.
SULT1E1 suppresses hepatocellular carcinoma progression via activation of the TGF-β/SMAD signaling pathway and cell cycle arrest.
Mechanism of IFITM1 regulating epidural scar hyperplasia after laminectomy through SMAD3/CBR4 pathway.
Discovery of protein lactylation-associated biomarkers and their potential pathogenic mechanisms in recurrent spontaneous abortion.
CRABP2 promotes peritoneal metastasis in CRC through TGF-β/Smad-mediated EMT signaling and invadopodia formation.
TSN Disrupts Fanconi Anemia Pathway Activation Through JAK/STAT1-Mediated Transcriptional Repression of FA Core Subunits in Bladder Cancer.
METTL3/IGF2BP2 stabilizes IQGAP3 via m6A modification to drive HCC metastasis through TGF-β/Smad signaling and EMT.
Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment.
Reduced glutathione enhances adipose tissue-derived mesenchymal stem cell engraftment efficiency for liver fibrosis by targeting TGFβ1/SMAD3/NOX4 pathway.
Omentin-1 attenuates atrial fibrillation via Src/PI3K/Akt signaling-mediated anti-fibrotic effects in cardiac fibroblasts.
[PSMD11 overexpression promotes epithelial-mesenchymal transition in gastric cancer and affects patient prognosis].
Integrated Proteomics Reveals Spliceosome Dysregulation and Highlights DHX9 as a TGF-β Signaling-Driven Fibrosis Hub in Endometriosis.
Sodium Hyaluronate-PDGF Repairs Cartilage and Subchondral Bone Microenvironment via HIF-1α-VEGF-Notch and SDF-1-CXCR4 Inhibition in Osteoarthritis.
ErTao decoction alleviates liver fibrosis by suppressing STING-mediated macrophages and NLRP3 inflammasome activation.
Autophagy inhibition enhances antifibrotic potential of placental mesenchymal stem cells of fetal origin via regulating TGF-β1 mediated protein degradation of HGF.
FATP5 modulates biological activity and lipid metabolism in prostate cancer through the TEAD4-mediated Hippo signaling.
Xu R, Cao G, Hou L, Fu W, Bi C, Li X, Wang X
Computational and structural biotechnology journal 2026;31:422-435
Computational and structural biotechnology journal 2026;31:422-435
Huanggan decoction ameliorates cholestatic hepatic fibrosis in rats via TGF-β1/Smad3 signaling pathway.
Lei Y, Ma X, Jin X, He Y, Yang J, Zhao Y, Chen J, Gao T
PloS one 2026;21(3):e0344168
PloS one 2026;21(3):e0344168
Mechanism of Platelet-Rich Plasma in Promoting Diabetic Wound Healing via the PI3K/AKT Signaling Pathway to Regulate Collagen Synthesis and Angiogenesis.
Liu H, Huang W, Jiang S, Yan B, Kong C, Zhu W, Xie Q, Cui C
Journal of diabetes research 2026;2026(1):e1254597
Journal of diabetes research 2026;2026(1):e1254597
YTHDF2 promotes arsenic carcinogenesis through m(6)A-dependent SMAD7 decay and PRR5 escape from decay.
Zhang Q, Man J, Cai J, Zhao T, Zhang Z
International journal of biological macromolecules 2026 Mar;348:150816
International journal of biological macromolecules 2026 Mar;348:150816
A Brain-Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF-β1/PI3K-AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses.
Han Z, Li X, Zhu Y, Wang Z, Hou Y, Tao H, Ma M, Xie X, Zhang H
Journal of cellular and molecular medicine 2026 Mar;30(5):e71065
Journal of cellular and molecular medicine 2026 Mar;30(5):e71065
CD14+ Monocytes Will Become a New Target for the Treatment of Osteoporosis: Based on Mendel Randomization, Clinical Analysis and Cell Experiment Verification.
Wang H, Ma X, Zhou P, Zhang J, Wang B, Liu J
Journal of cellular and molecular medicine 2026 Jan;30(2):e71024
Journal of cellular and molecular medicine 2026 Jan;30(2):e71024
SULT1E1 suppresses hepatocellular carcinoma progression via activation of the TGF-β/SMAD signaling pathway and cell cycle arrest.
Zhang W, Peng J, Dai D, Huang C, Liu F, Chen X
BMC gastroenterology 2026 Feb 11;26(1)
BMC gastroenterology 2026 Feb 11;26(1)
Mechanism of IFITM1 regulating epidural scar hyperplasia after laminectomy through SMAD3/CBR4 pathway.
Wang H, Zhu Z, Liu J
Frontiers in immunology 2025;16:1628970
Frontiers in immunology 2025;16:1628970
Discovery of protein lactylation-associated biomarkers and their potential pathogenic mechanisms in recurrent spontaneous abortion.
Yan X, Wang X, Sun X, Jiao J
International journal of biological macromolecules 2025 Sep;321(Pt 4):146004
International journal of biological macromolecules 2025 Sep;321(Pt 4):146004
CRABP2 promotes peritoneal metastasis in CRC through TGF-β/Smad-mediated EMT signaling and invadopodia formation.
Hao W, Dong X, Wang Z, Wen T, Liu L, Gu T, Ma H
Cellular signalling 2025 Oct;134:111927
Cellular signalling 2025 Oct;134:111927
TSN Disrupts Fanconi Anemia Pathway Activation Through JAK/STAT1-Mediated Transcriptional Repression of FA Core Subunits in Bladder Cancer.
Zhao W, Xie Z, Zhu L, Li W
Dose-response : a publication of International Hormesis Society 2025 Oct-Dec;23(4):15593258251406039
Dose-response : a publication of International Hormesis Society 2025 Oct-Dec;23(4):15593258251406039
METTL3/IGF2BP2 stabilizes IQGAP3 via m6A modification to drive HCC metastasis through TGF-β/Smad signaling and EMT.
Pan D, Zhang H, Zhou J, He S, Yuan G
Pathology, research and practice 2025 Nov;275:156228
Pathology, research and practice 2025 Nov;275:156228
Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment.
Bi L, Wang J, Yang J, Zhuang Z, Chen K, Xu Z, Zuo X, Xu J, Sheng Y, Cui Y
Clinical proteomics 2025 May 29;22(1):22
Clinical proteomics 2025 May 29;22(1):22
Reduced glutathione enhances adipose tissue-derived mesenchymal stem cell engraftment efficiency for liver fibrosis by targeting TGFβ1/SMAD3/NOX4 pathway.
Yu S, Wang Y, Shi Y, Yu S, Zhao B, Liao N, Liu X
Bioengineering & translational medicine 2025 Mar;10(2):e10735
Bioengineering & translational medicine 2025 Mar;10(2):e10735
Omentin-1 attenuates atrial fibrillation via Src/PI3K/Akt signaling-mediated anti-fibrotic effects in cardiac fibroblasts.
Li TL, Zhu NN, Zhao MX, Sun J, Yin Z, Xie P, Huang JH, Guo JP, Yuan HT, Li SX, Zhao-Liang S
European journal of pharmacology 2025 Jun 5;996:177588
European journal of pharmacology 2025 Jun 5;996:177588
[PSMD11 overexpression promotes epithelial-mesenchymal transition in gastric cancer and affects patient prognosis].
Zhou R, Yang J, Song B, Chen X, Wang L, Wang Y, Zuo L, Zhu B
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Dec 20;45(12):2747-2755
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Dec 20;45(12):2747-2755
Integrated Proteomics Reveals Spliceosome Dysregulation and Highlights DHX9 as a TGF-β Signaling-Driven Fibrosis Hub in Endometriosis.
Yang M, Zhang L, Ding X, Wei P, Zhang H, Chen J, Zhang Y, Li D, Chen Z, Lin D, Huang Z, Chen Q
Journal of proteome research 2025 Aug 1;24(8):4044-4059
Journal of proteome research 2025 Aug 1;24(8):4044-4059
Sodium Hyaluronate-PDGF Repairs Cartilage and Subchondral Bone Microenvironment via HIF-1α-VEGF-Notch and SDF-1-CXCR4 Inhibition in Osteoarthritis.
Wang Z, Zhu P, Li H, Ye B, Luo Q, Cheng J, Cai Y
Journal of cellular and molecular medicine 2025 Apr;29(7):e70515
Journal of cellular and molecular medicine 2025 Apr;29(7):e70515
ErTao decoction alleviates liver fibrosis by suppressing STING-mediated macrophages and NLRP3 inflammasome activation.
Jia H, Li J, Chen X, Liu Z, Wu C, Liu C, Zhang J, Luo M, Huang M, Huang S, Cai M, Gao L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156489
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156489
Autophagy inhibition enhances antifibrotic potential of placental mesenchymal stem cells of fetal origin via regulating TGF-β1 mediated protein degradation of HGF.
Zhou W, Wang J, Ding L, Cai R, Cheng J, Liang P, Zhu Y, Zhang Z
Scientific reports 2025 Apr 21;15(1):13805
Scientific reports 2025 Apr 21;15(1):13805
FATP5 modulates biological activity and lipid metabolism in prostate cancer through the TEAD4-mediated Hippo signaling.
Liu S, He Y, Gu Z
Frontiers in oncology 2024;14:1442911
Frontiers in oncology 2024;14:1442911
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