Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AMM00006G - Provider product page
- Provider
- Leading Biology
- Product name
- Proteinase Inhibitor 9 (PI-9) Antibody (Clone PI9-17)
- Antibody type
- Monoclonal
- Description
- Proteinase inhibitor 9 (PI-9, also designated cytoplasmic antiproteinase 3, or CAP3) is a 42 kDa member of the ovalbumin family of serpins that is expressed in placenta, lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and of granzyme B-mediated apoptosis, and is also an inhibitor of capase-1 and, to a smaller extent, caspase-4 and caspase-8. PI-9 expression is also upregulated in response to inflammatory stimuli. This upregulation protects cells from apoptosis induced by endogenously expressed or released granzyme B, particulary during target cell killling.
- Reactivity
- Human
- Host
- Mouse
- Antibody clone number
- PI9-17
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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