19508-1-AP

antibody from Proteintech Group

Targeting: PACS2 KIAA0602, PACS1L

Provider product page for 19508-1-AP

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [17]
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Validations
Western blot [1]

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Product number: 19508-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19508-1-AP, RRID:AB_10643387
Product name: PACS2-Specific antibody
Antibody type: Polyclonal
Description: KD/KO validated PACS2-Specific antibody (Cat. #19508-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PACS2 protein structure - 19508-1-AP shown in red.

Submitted references MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism.

Liu S, Han S, Wang C, Chen H, Xu Q, Feng S, Wang Y, Yao J, Zhou Q, Tang X, Lin L, Hu L, Davidson AJ, Yang B, Ye C, Yang F, Mao J, Tong C, Chen J, Jiang H
International journal of biological sciences 2024;20(2):569-584

CGI1746 targets σ(1)R to modulate ferroptosis through mitochondria-associated membranes.

Zhang Z, Zhou H, Gu W, Wei Y, Mou S, Wang Y, Zhang J, Zhong Q
Nature chemical biology 2024 Jun;20(6):699-709

PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.

Yang J, Li L, Li C, Chen W, Liu Y, Luo S, Zhao C, Han Y, Yang M, Zhao H, Jiang N, Xi Y, Tang C, Cai J, Xiao L, Liu H, Sun L
Cell death & disease 2023 Oct 4;14(10):649

Icariin inhibits the formation of mitochondria-associated membranes (MAMs) and improves erectile function in rats treated with prostate radiation.

Deng CJ, Li X, Zeng Y, Jiang J, Jiang R
Andrology 2022 Sep;10(6):1208-1216

PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease.

Zhao C, Li L, Li C, Tang C, Cai J, Liu Y, Yang J, Xi Y, Yang M, Jiang N, Han Y, Liu Y, Luo S, Xiao L, Sun L
Molecular medicine (Cambridge, Mass.) 2022 Sep 23;28(1):117

PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.

Li C, Li L, Yang M, Yang J, Zhao C, Han Y, Zhao H, Jiang N, Wei L, Xiao Y, Liu Y, Xiong X, Xi Y, Luo S, Deng F, Chen W, Yuan S, Zhu X, Xiao L, Sun L
Diabetes 2022 May 1;71(5):1034-1050

PACS2-TRPV1 axis is required for ER-mitochondrial tethering during ER stress and lung fibrosis.

Knoell J, Chillappagari S, Knudsen L, Korfei M, Dartsch R, Jonigk D, Kuehnel MP, Hoetzenecker K, Guenther A, Mahavadi P
Cellular and molecular life sciences : CMLS 2022 Feb 25;79(3):151

Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins.

Herrera-Cruz MS, Yap MC, Tahbaz N, Phillips K, Thomas L, Thomas G, Simmen T
Biology direct 2021 Nov 7;16(1):22

Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL‑6/STAT3 signaling pathway.

Shi W, Men L, Pi X, Jiang T, Peng D, Huo S, Luo P, Wang M, Guo J, Jiang Y, Peng L, Lin L, Li S, Lv J
International journal of oncology 2021 Dec;59(6)

Targeting mitochondria-associated membranes as a potential therapy against endothelial injury induced by hypoxia.

Yang YD, Li MM, Xu G, Zhang EL, Chen J, Sun B, Chen DW, Gao YQ
Journal of cellular biochemistry 2019 Nov;120(11):18967-18978

The Multifunctional Sorting Protein PACS-2 Controls Mitophagosome Formation in Human Vascular Smooth Muscle Cells through Mitochondria-ER Contact Sites.

Moulis M, Grousset E, Faccini J, Richetin K, Thomas G, Vindis C
Cells 2019 Jun 25;8(6)

PACS2 is required for ox-LDL-induced endothelial cell apoptosis by regulating mitochondria-associated ER membrane formation and mitochondrial Ca(2+) elevation.

Yu S, Zhang L, Liu C, Yang J, Zhang J, Huang L
Experimental cell research 2019 Jun 15;379(2):191-202

MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.

Takeda K, Nagashima S, Shiiba I, Uda A, Tokuyama T, Ito N, Fukuda T, Matsushita N, Ishido S, Iwawaki T, Uehara T, Inatome R, Yanagi S
The EMBO journal 2019 Aug 1;38(15):e100999

Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo.

Wu S, Lu Q, Ding Y, Wu Y, Qiu Y, Wang P, Mao X, Huang K, Xie Z, Zou MH
Circulation 2019 Apr 16;139(16):1913-1936

Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.

Haile Y, Deng X, Ortiz-Sandoval C, Tahbaz N, Janowicz A, Lu JQ, Kerr BJ, Gutowski NJ, Holley JE, Eggleton P, Giuliani F, Simmen T
Journal of neuroinflammation 2017 Jan 23;14(1):19

The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.

Dombernowsky SL, Samsøe-Petersen J, Petersen CH, Instrell R, Hedegaard AM, Thomas L, Atkins KM, Auclair S, Albrechtsen R, Mygind KJ, Fröhlich C, Howell M, Parker P, Thomas G, Kveiborg M
Nature communications 2015 Jun 25;6:7518

Autophagosomes form at ER-mitochondria contact sites.

Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T
Nature 2013 Mar 21;495(7441):389-93

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PACS2-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human PACS2-Specific. This antibody recognizes human,mouse,rat antigen. The PACS2-Specific antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 19508-1-AP.pdf

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