659302

antibody from BioLegend

Targeting: RUNX1 AML1, AMLCR1, CBFA2, PEBP2A2

Immunocytochemistry

Antibody data

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Validation data

Product number: 659302 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#659302, RRID:AB_2563194
Product name: Purified anti-RUNX1
Antibody type: Monoclonal
Antigen: Partial human RUNX1 recombinant protein (191-350 aa) expressed in E. coli.
Description: RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. RUNX1 was first identified as a RUNX1-ETO fusion protein in acute myeloid leukaemia (AML) and is frequently mutated in AML and myelodysplastic syndrome due to chromosomal translocation. RUNX1-deficient mice fail to generate hematopoietic stem cells. RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. Impaired differentiation of megakaryocytes and decreased circulating platelet count was observed in the absence of RUNX1. These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Antibody clone number: 1C5B16
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: 2°C-8°C
Handling: Ambient RT

RUNX1 protein structure - 659302 shown in red.