BS1717

antibody from Bioworld Technology, Inc
Targeting: RUNX1 AML1, AMLCR1, CBFA2, PEBP2A2
Provider product page for BS1717
Western blot
Immunohistochemistry

Antibody data

Product number
BS1717 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1717, RRID:AB_1662957
Product name
RUNX1 (T270) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 250-300 of Human RUNX1.
Description
AML1 (also known as Runx1, CBFA2, and PEBP2Ï«B) is a member of the core binding factor (CBF) family of transcription factors. It is required for normal development of all hematopoietic lineages. AML1 forms a heterodimeric DNA binding complex with its partner protein CBFÉÇ and regulates the expression of cellular genes by binding to promoter and enhancer elements. AML1 is commonly translocated in hematopoietic cancers: chromosomal translocations include t(8;21) AML1-ETO, t(12;21) TEL-AML, and t(8;21) AML-M2. Phosphorylation of AML1 on several potential serine and threonine sites, including Ser249, is thought to occur in an Erk-dependent manner.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RUNX1 protein structure - BS1717 shown in red.