Antibody data

Product number
11-7555 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-Vimentin Antibody
Antibody type
Polyclonal
Description
Vimentin is a major constituent of the intermediate filament family of proteins whose expression correlates with increased metastatic disease, reduced patient survival and poor prognosis across multiple tumor types. It is ubiquitously expressed in normal mesenchymal cells and is known to maintain cellular integrity and provide resistance against stress. Vimentin is overexpressed in various epithelial cancers, including prostate cancer, gastrointestinal tumors, tumors of the central nervous system, breast cancer, malignant melanoma, and lung cancer. Vimentin shows dynamically altered expression patterns during different developmental stages and high sequence homology throughout all vertebrates, suggesting that the protein is physiologically important.Its overexpression in cancer correlates with accelerated tumor growth, invasion, and poor prognosis; however, the role of vimentin in cancer progression remains obscure. In the recent years, vimentin has gained much importance as a marker for epithelial-mesenchymal transition (EMT).
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant Viment
in protein (amino acids 52-231) was
used as the immunogen for this ant
ibody.
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
VIM protein structure - 11-7555 shown in red.