Explore
Validate
Learn
Other assayAntibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Other assay [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 13-5800 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- P-cadherin Monoclonal Antibody (NCC-CAD-299)
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Source: Monoclonal antibody was obtained by fusing the mouse myeloma cell-line P3-X63-Ag8-U1 with spleen cells of BALB/c mouse after immunization with human epidermal carcinoma cell A431.1) The monoclonal antibody was harvested from ascitic fluid.
- Antibody clone number
- NCC-CAD-299
- Concentration
- 2.0 mg/mL
Submitted references An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.
Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells.
Increased shedding of soluble fragments of P-cadherin in nipple aspirate fluids from women with breast cancer.
Cadherin switching dictates the biology of transitional cell carcinoma of the bladder: ex vivo and in vitro studies.
Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.
The fate of E- and P-cadherin during the early stages of apoptosis.
The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts.
The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts.
Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM, Klein OD
Cell stem cell 2017 Jul 6;21(1):91-106.e6
Cell stem cell 2017 Jul 6;21(1):91-106.e6
Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells.
Ribeiro AS, Albergaria A, Sousa B, Correia AL, Bracke M, Seruca R, Schmitt FC, Paredes J
Oncogene 2010 Jan 21;29(3):392-402
Oncogene 2010 Jan 21;29(3):392-402
Increased shedding of soluble fragments of P-cadherin in nipple aspirate fluids from women with breast cancer.
Mannello F, Tonti GA, Medda V, Pederzoli A, Sauter ER
Cancer science 2008 Nov;99(11):2160-9
Cancer science 2008 Nov;99(11):2160-9
Cadherin switching dictates the biology of transitional cell carcinoma of the bladder: ex vivo and in vitro studies.
Bryan RT, Atherfold PA, Yeo Y, Jones LJ, Harrison RF, Wallace DM, Jankowski JA
The Journal of pathology 2008 Jun;215(2):184-94
The Journal of pathology 2008 Jun;215(2):184-94
Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.
Müller N, Reinacher-Schick A, Baldus S, van Hengel J, Berx G, Baar A, van Roy F, Schmiegel W, Schwarte-Waldhoff I
Oncogene 2002 Sep 5;21(39):6049-58
Oncogene 2002 Sep 5;21(39):6049-58
The fate of E- and P-cadherin during the early stages of apoptosis.
Schmeiser K, Grand RJ
Cell death and differentiation 1999 Apr;6(4):377-86
Cell death and differentiation 1999 Apr;6(4):377-86
The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts.
Braga VM, Machesky LM, Hall A, Hotchin NA
The Journal of cell biology 1997 Jun 16;137(6):1421-31
The Journal of cell biology 1997 Jun 16;137(6):1421-31
The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts.
Braga VM, Machesky LM, Hall A, Hotchin NA
The Journal of cell biology 1997 Jun 16;137(6):1421-31
The Journal of cell biology 1997 Jun 16;137(6):1421-31
No comments: Submit comment
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- 6 Modulation of RT4 growth on collagen after 5 days. (A) RT4 growth without antibody (negative experimental control). (B) RT4 growth in the presence of anti-CK20 antibody (negative antibody control). (C) RT4 growth in the presence of anti-P-cadherin function-blocking antibody. (A-C) All show RT4 forming tight rounded multicellular colonies without any noticeable morphological changes. (D) RT4 growth in the presence of anti-E-cadherin function-blocking antibody, with the cells clustering together but seemingly unable to form tight rounded multicellular colonies
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- 5 Modulation of RT4 growth on plastic after 24 h. (A) RT4 growth without antibody (negative experimental control). (B) RT4 growth in the presence of anti-CK20 antibody (negative antibody control). (C, D) RT4 growth in the presence of anti-P-cadherin function blocking antibody. (E, F) RT4 growth in the presence of anti-E-cadherin function-blocking antibody
