- 32-4000 - Invitrogen Antibodies CDH3 antibody

Submitted references Biphasic Squamoid Alveolar Renal Cell Carcinoma: A Distinctive Subtype of Papillary Renal Cell Carcinoma?

Hes O, Condom Mundo E, Peckova K, Lopez JI, Martinek P, Vanecek T, Falconieri G, Agaimy A, Davidson W, Petersson F, Bulimbasic S, Damjanov I, Jimeno M, Ulamec M, Podhola M, Sperga M, Pane Foix M, Shelekhova K, Kalusova K, Hora M, Rotterova P, Daum O, Pivovarcikova K, Michal M
The American journal of surgical pathology 2016 May;40(5):664-75

HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway.

Xue M, Yao S, Hu M, Li W, Hao T, Zhou F, Zhu X, Lu H, Qin D, Yan Q, Zhu J, Gao SJ, Lu C
Nucleic acids research 2014 Sep;42(15):9862-79

Novel three-dimensional in vitro models of ovarian endometriosis.

Brueggmann D, Templeman C, Starzinski-Powitz A, Rao NP, Gayther SA, Lawrenson K
Journal of ovarian research 2014 Feb 6;7:17

A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro.

Lee JM, Mhawech-Fauceglia P, Lee N, Parsanian LC, Lin YG, Gayther SA, Lawrenson K
Laboratory investigation; a journal of technical methods and pathology 2013 May;93(5):528-42

P-cadherin is a direct PAX3-FOXO1A target involved in alveolar rhabdomyosarcoma aggressiveness.

Thuault S, Hayashi S, Lagirand-Cantaloube J, Plutoni C, Comunale F, Delattre O, Relaix F, Gauthier-Rouvière C
Oncogene 2013 Apr 11;32(15):1876-87

Sporadic hybrid oncocytic/chromophobe tumor of the kidney: a clinicopathologic, histomorphologic, immunohistochemical, ultrastructural, and molecular cytogenetic study of 14 cases.

Petersson F, Gatalica Z, Grossmann P, Perez Montiel MD, Alvarado Cabrero I, Bulimbasic S, Swatek A, Straka L, Tichy T, Hora M, Kuroda N, Legendre B, Michal M, Hes O
Virchows Archiv : an international journal of pathology 2010 Apr;456(4):355-65

JNK signaling pathway is required for bFGF-mediated surface cadherin downregulation on HUVEC.

Wu JC, Yan HC, Chen WT, Chen WH, Wang CJ, Chi YC, Kao WY
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Differences in invasive capacity of endometrial cancer cell lines expressing different progesterone receptor isotypes: possible involvement of cadherins.

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Journal of the Society for Gynecologic Investigation 2005 May;12(4):278-84

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Supportive validation

Submitted by: Invitrogen Antibodies (provider)
Main image
Experimental details: Figure 7. miR-718 mediates K1- and Nef-induced angiogenesis both in vitro and in vivo . ( A ) Matrigel assay analysis of microtubule formation. Tube formation assay was performed with HUVECs transduced with K1, incubated with soluble Nef protein for 72 h or both and further transfected with negative control nucleotide of miRNA (Neg. Ctrl.; top) or inhibitor of miR-718 (miR-718 inhibitor; bottom) for 48 h, respectively. The photographs of microtubules were captured at 16 h post seeding (original magnification, x100). ( B ) Quantification of results in (A). The results represent the mean +- SD from three independent experiments ( n = 3), each experiment containing six technical replicates. ( C ) Inhibition of miR-718 suppressed the enhanced effect of Nef on K1-induced angiogenesis. HUVECs transduced with K1, incubated with soluble Nef protein for 72 h or both were transfected with negative control nucleotide of miRNA (Neg. Ctrl.; top) or inhibitor of miR-718 (miR-718 inhibitor; bottom) for 48 h. The collected cells were mixed with Matrigel and subsequently implanted onto the CAM. Representative photographs of angiogenesis on the CAM are shown. ( D ) Quantification of results in (C). The number of blood vessels is expressed as the mean +- SD from three independent experiments ( n = 3), each experiment containing six technical replicates. ( E ) Western blot analysis of total PTEN and phosphorylation levels of AKT and mTOR. The tumor tissues from CAM that treated as in (C) were co

Supportive validation

Submitted by: Invitrogen Antibodies (provider)
Main image
Experimental details: Figure 8. miR-718 mediates K1- and Nef-induced tumorigenesis in nude mice. ( A ) Inhibition of miR-718 abrogates the enhanced effect of Nef on K1-induced tumorigenesis. EA.hy926 cells transduced with K1, Nef or both were infected with control virus (pCDH) or miR-718 sponge for 72 h and further re-suspended in serum-free medium. As detailed in the 'Materials and Methods' section, the treated cells were injected (s.c.) into nude mice. The sizes of tumors from nude mice were determined by two-dimensional caliper measurements. Data represent mean +- SD, each group with five tumors ( n = 5). Two independent experiments were performed and similar results were obtained. ** and *** indicate P < 0.01 and P < 0.001 by Student's t -test, respectively. ( B ) Tumor-bearing mice were killed at day 56 after injections, and tumors were removed and pictures were taken. ( C ) Inhibition of miR-718 abrogates the enhanced effect of Nef on K1-induced tumorigenesis. The tumors from nude mice treated as in (A) were removed and weighed. Scatter plots represent the weights of independent tumors from different groups. Data represent mean +- SD, each group with five tumors ( n = 5). Two independent experiments were performed and similar results were obtained. ( D ) Inhibition of miR-718 increased total PTEN level and suppressed the enhanced phosphorylation of AKT and mTOR by K1 and Nef. The tumor tissues from nude mice treated as in (A) were removed, and the expression of total PTEN, pho

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