Antibody data
- Antibody Data
- Antigen structure
- References [111]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
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- Product number
- 10099-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10099-1-AP, RRID:AB_2239240
- Product name
- SIRT3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SIRT3 antibody (Cat. #10099-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway.
Integrated analysis reveals crosstalk between pyroptosis and immune regulation in renal fibrosis.
Resveratrol protects against myocardial ischemic injury in obese mice via activating SIRT3/FOXO3a signaling pathway and restoring redox homeostasis.
Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis.
Phosphatidylserine Counteracts the High Stocking Density-Induced Stress Response, Redox Imbalance and Immunosuppression in Fish Megalobrama ambylsephala.
The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia-reperfusion-induced renal fibrosis.
KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.
Corn Oligopeptide Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Sirtuin Signaling Pathway.
The Effectiveness of Four Nicotinamide Adenine Dinucleotide (NAD(+)) Precursors in Alleviating the High-Glucose-Induced Damage to Hepatocytes in Megalobrama amblycephala: Evidence in NAD(+) Homeostasis, Sirt1/3 Activation, Redox Defense, Inflammatory Response, Apoptosis, and Glucose Metabolism.
Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.
Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia.
Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.
Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.
Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3.
Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway.
Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway.
Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway.
SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages.
Metabolic reprogramming induced by DCA enhances cisplatin sensitivity through increasing mitochondrial oxidative stress in cholangiocarcinoma.
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity.
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis.
Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling.
Bioactivity-based molecular networking-guided identification of guttiferone J from Garcinia cambogia as an anti-obesity candidate.
Effects of Exercise Preconditioning on Doxorubicin-Induced Liver and Kidney Toxicity in Male and Female Rats.
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Resveratrol reverses TGF-β1-mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis.
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics.
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated m(6)A modification of SIRT3 mRNA.
Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models.
SIRT3 Regulates Levels of Deacetylated SOD2 to Prevent Oxidative Stress and Mitochondrial Dysfunction During Oocyte Maturation in Pigs.
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Combination of Perindopril Erbumine and Huangqi-Danshen Decoction Protects Against Chronic Kidney Disease via Sirtuin3/Mitochondrial Dynamics Pathway.
Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage.
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway.
Atractylon inhibits the tumorigenesis of glioblastoma through SIRT3 signaling.
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Fraxinellone inhibits progression of glioblastoma via regulating the SIRT3 signaling pathway.
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
[Effects of Long-Term Ethanol Consumption on Learning-Memory Functions in Mice and the Mechanisms Involved].
Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway.
Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling.
Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation.
SIRT3-AMPK signaling pathway as a protective target in endothelial dysfunction of early sepsis.
Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.
Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin-induced acute kidney injury.
Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3.
The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3.
The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells.
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis.
Antimelanoma Effects of Concomitant Inhibition of SIRT1 and SIRT3 in Braf(V600E)/Pten(NULL) Mice.
Honokiol improves endothelial function in type 2 diabetic rats via alleviating oxidative stress and insulin resistance.
The Protective Effect of 1,25(OH)(2)D(3) on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism.
Jian-Pi-Yi-Shen Formula Alleviates Chronic Kidney Disease in Two Rat Models by Modulating QPRT/NAD(+)/SIRT3/Mitochondrial Dynamics Pathway.
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects.
Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.
CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice.
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3.
Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels.
Endurance Exercise-Induced Autophagy/Mitophagy Coincides with a Reinforced Anabolic State and Increased Mitochondrial Turnover in the Cortex of Young Male Mouse Brain.
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.
Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling.
Proteomic analysis of lysine acetylation reveals that metabolic enzymes and heat shock proteins may be potential targets for DSS-induced mice colitis.
Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3.
Dioscin Protects against Aβ1-42 Oligomers-Induced Neurotoxicity via the Function of SIRT3 and Autophagy.
Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy.
SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels.
Anomalous AMPK-regulated angiotensin AT(1)R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.
SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity.
RGD-PEG-PLA Delivers MiR-133 to Infarct Lesions of Acute Myocardial Infarction Model Rats for Cardiac Protection.
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Activated PI3K/AKT Signaling Pathway Associates with Oxidative Stress and Impaired Developmental Potential of Vitrified-Thawed Oocytes.
Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock.
Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats.
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Modulation of mitochondrial phenotypes by endurance exercise contributes to neuroprotection against a MPTP-induced animal model of PD.
Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration.
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia.
Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity.
Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells.
Sun M, Wang F, Li H, Li M, Wang Y, Wang C, Zhang Y, Zhang D, Li J, Yao S
Journal of inflammation research 2024;17:1349-1364
Journal of inflammation research 2024;17:1349-1364
Integrated analysis reveals crosstalk between pyroptosis and immune regulation in renal fibrosis.
Bai F, Han L, Yang J, Liu Y, Li X, Wang Y, Jiang R, Zeng Z, Gao Y, Zhang H
Frontiers in immunology 2024;15:1247382
Frontiers in immunology 2024;15:1247382
Resveratrol protects against myocardial ischemic injury in obese mice via activating SIRT3/FOXO3a signaling pathway and restoring redox homeostasis.
Zhu X, Ma E, Ge Y, Yuan M, Guo X, Peng J, Zhu W, Ren DN, Wo D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116476
Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis.
Han X, Ning Y, Dou X, Wang Y, Shan Q, Shi K, Wang Z, Ding C, Hao M, Wang K, Peng M, Kuang H, Yang Q, Sang X, Cao G
Journal of pharmaceutical analysis 2024 May;14(5):100927
Journal of pharmaceutical analysis 2024 May;14(5):100927
Phosphatidylserine Counteracts the High Stocking Density-Induced Stress Response, Redox Imbalance and Immunosuppression in Fish Megalobrama ambylsephala.
Jiang Y, Liu Z, Zhang L, Liu W, Li H, Li X
Antioxidants (Basel, Switzerland) 2024 May 25;13(6)
Antioxidants (Basel, Switzerland) 2024 May 25;13(6)
The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia-reperfusion-induced renal fibrosis.
Wu H, Wang L, Kang P, Zhou X, Li W, Xia Z
International immunopharmacology 2024 May 10;132:112002
International immunopharmacology 2024 May 10;132:112002
KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.
Zhou J, Wang T, Zhang H, Liu J, Wei P, Xu R, Yan Q, Chen G, Li W, Gao SJ, Lu C
PLoS pathogens 2024 Mar;20(3):e1012082
PLoS pathogens 2024 Mar;20(3):e1012082
Corn Oligopeptide Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Sirtuin Signaling Pathway.
Xu Y, Su T, Mishra H, Ando R, Furutani Y, Lu J, Cai M, Suzuki H, Yu W, Qin XY
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6360-6371
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6360-6371
The Effectiveness of Four Nicotinamide Adenine Dinucleotide (NAD(+)) Precursors in Alleviating the High-Glucose-Induced Damage to Hepatocytes in Megalobrama amblycephala: Evidence in NAD(+) Homeostasis, Sirt1/3 Activation, Redox Defense, Inflammatory Response, Apoptosis, and Glucose Metabolism.
Dong Y, Wang X, Wei L, Liu Z, Chu X, Xiong W, Liu W, Li X
Antioxidants (Basel, Switzerland) 2024 Mar 22;13(4)
Antioxidants (Basel, Switzerland) 2024 Mar 22;13(4)
Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.
Yang W, Qiu C, Lv H, Zhang Z, Yao T, Huang L, Wu G, Zhang X, Chen J, He Y
Translational vision science & technology 2024 Mar 1;13(3):19
Translational vision science & technology 2024 Mar 1;13(3):19
Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia.
Chen LL, Li YQ, Kang ZH, Zhang X, Gu SY, Wang N, Shen XY
Molecular and cellular endocrinology 2024 Jan 1;579:112073
Molecular and cellular endocrinology 2024 Jan 1;579:112073
Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.
Wei Y, Wang X, Ma Z, Xiang P, Liu G, Yin B, Hou L, Shu P, Liu W, Peng X
iScience 2024 Feb 16;27(2):108706
iScience 2024 Feb 16;27(2):108706
Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.
Zhang A, Pan Y, Wang H, Ding R, Zou T, Guo D, Shen Y, Ji P, Huang W, Wen Q, Wang Q, Hu H, Wu J, Xiang M, Ye B
Aging cell 2024 Apr;23(4):e14091
Aging cell 2024 Apr;23(4):e14091
Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3.
Zhang W, Fan Z, Wang F, Yin L, Wu J, Li D, Song S, Wang X, Tang Y, Huang C
Oxidative medicine and cellular longevity 2023;2023:9966355
Oxidative medicine and cellular longevity 2023;2023:9966355
Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway.
Xiao L, Fang Z, Wang Q, Sheng X, Qi X, Xing K, Guo Y, Ni H, Wang X, Zhang Y
Oxidative medicine and cellular longevity 2023;2023:1708251
Oxidative medicine and cellular longevity 2023;2023:1708251
Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway.
Jin X, He R, Lin Y, Liu J, Wang Y, Li Z, Liao Y, Yang S
Drug design, development and therapy 2023;17:3363-3383
Drug design, development and therapy 2023;17:3363-3383
Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway.
He H, Liu P, Li P
Drug design, development and therapy 2023;17:3205-3218
Drug design, development and therapy 2023;17:3205-3218
SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages.
Guo M, Zhuang H, Su Y, Meng Q, Liu W, Liu N, Wei M, Dai SM, Deng H
Frontiers in immunology 2023;14:1128543
Frontiers in immunology 2023;14:1128543
Metabolic reprogramming induced by DCA enhances cisplatin sensitivity through increasing mitochondrial oxidative stress in cholangiocarcinoma.
Qin H, Zheng G, Li Q, Shen L
Frontiers in pharmacology 2023;14:1128312
Frontiers in pharmacology 2023;14:1128312
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Koh YC, Lin SJ, Hsu KY, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
Wang X, Wu H, An J, Zhang G, Chen Y, Fu L, Tao L, Liang G, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
Zhan R, Meng X, Tian D, Xu J, Cui H, Yang J, Xu Y, Shi M, Xue J, Yu W, Hu G, Li K, Ge X, Zhang Q, Zhao M, Du J, Guo X, Xu W, Gao Y, Yao C, Chen F, Chen Y, Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E, Wang Y, Zheng L
Neuron 2023 Nov 15;111(22):3634-3649.e7
Neuron 2023 Nov 15;111(22):3634-3649.e7
Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity.
Kong W, Peng Y, Ji C, Liu Z, Gao S, Zhang Y, Chen J, Li X, Bao M, Zhang Y, Jiang Q, Wang F, Li Z, Bian X, Ye J
Clinical science (London, England : 1979) 2023 May 31;137(10):823-841
Clinical science (London, England : 1979) 2023 May 31;137(10):823-841
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B
Diabetes 2023 May 1;72(5):611-626
Diabetes 2023 May 1;72(5):611-626
Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis.
Zi Y, Wang X, Zi Y, Yu H, Lan Y, Fan Y, Ren C, Liao K, Chen H
Free radical biology & medicine 2023 May 1;200:73-86
Free radical biology & medicine 2023 May 1;200:73-86
Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling.
Liu LW, Xie Y, Li GQ, Zhang T, Sui YH, Zhao ZJ, Zhang YY, Yang WB, Geng XL, Xue DB, Chen H, Wang YW, Lu TQ, Shang LR, Li ZB, Li L, Sun B
British journal of pharmacology 2023 Mar;180(5):647-666
British journal of pharmacology 2023 Mar;180(5):647-666
Bioactivity-based molecular networking-guided identification of guttiferone J from Garcinia cambogia as an anti-obesity candidate.
Feng Z, Chen J, Chen C, Feng L, Wang R, Zhu J, Lou R, Liu J, Ye Y, Lin L
British journal of pharmacology 2023 Mar;180(5):589-608
British journal of pharmacology 2023 Mar;180(5):589-608
Effects of Exercise Preconditioning on Doxorubicin-Induced Liver and Kidney Toxicity in Male and Female Rats.
Boeno FP, Patel J, Montalvo RN, Lapierre-Nguyen SS, Schreiber CM, Smuder AJ
International journal of molecular sciences 2023 Jun 16;24(12)
International journal of molecular sciences 2023 Jun 16;24(12)
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Koh YC, Chok D, Chang CH, Wei CC, Wu CT, Cheng KC, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
Wei Y, Xiao G, Xu H, Sun X, Shi Y, Wang F, Kang J, Peng J, Zhou F
The FEBS journal 2023 Jul;290(14):3629-3645
The FEBS journal 2023 Jul;290(14):3629-3645
SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.
Huang P, Zhao H, Pan X, Li J, Pan W, Dai H, Wang J, Xia C, Liu F
Biochemical pharmacology 2023 Jul;213:115592
Biochemical pharmacology 2023 Jul;213:115592
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Qin Y, Shi Y, Yu Q, Yang S, Wang Y, Dai X, Li G, Cheng Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114761
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114761
Resveratrol reverses TGF-β1-mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis.
Wang J, Huang P, Pan X, Xia C, Zhang H, Zhao H, Yuan Z, Liu J, Meng C, Liu F
Phytotherapy research : PTR 2023 Jan;37(1):211-230
Phytotherapy research : PTR 2023 Jan;37(1):211-230
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
Li Y, Shen B, Lv C, Zhu X, Naren Q, Xu D, Chen H, Wu F
International immunopharmacology 2023 Jan;114:109489
International immunopharmacology 2023 Jan;114:109489
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
Lin S, Yang F, Hu M, Chen J, Chen G, Hu A, Li X, Fu D, Xing C, Xiong Z, Wu Y, Cao H
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics.
Wang R, Xu H, Tan B, Yi Q, Sun Y, Xiang H, Chen T, Liu H, Xie Q, Wang L, Tian J, Zhu J
Free radical biology & medicine 2023 Feb 1;195:270-282
Free radical biology & medicine 2023 Feb 1;195:270-282
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, Wang H, Ji Y, Xie LP, Gu AH, Sun CQ, Wang QM, Wang LS
Archives of toxicology 2023 Dec;97(12):3209-3226
Archives of toxicology 2023 Dec;97(12):3209-3226
Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated m(6)A modification of SIRT3 mRNA.
Zhang Y, Wang R, Tan H, Wu K, Hu Y, Diao H, Wang D, Tang X, Leng M, Li X, Cai Z, Luo D, Shao X, Yan M, Chen Y, Rong X, Guo J
Journal of ethnopharmacology 2023 Dec 5;317:116766
Journal of ethnopharmacology 2023 Dec 5;317:116766
Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models.
Sanz-Alcázar A, Britti E, Delaspre F, Medina-Carbonero M, Pazos-Gil M, Tamarit J, Ros J, Cabiscol E
Cellular and molecular life sciences : CMLS 2023 Dec 21;81(1):12
Cellular and molecular life sciences : CMLS 2023 Dec 21;81(1):12
SIRT3 Regulates Levels of Deacetylated SOD2 to Prevent Oxidative Stress and Mitochondrial Dysfunction During Oocyte Maturation in Pigs.
Jiao L, Hu CX, Zhang Y, Zhang YX, Cai WW, Pan WL, Sun SC, Zhang Y
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 Dec 21;29(6):2149-2160
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 Dec 21;29(6):2149-2160
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Cong L, Liu X, Bai Y, Qin Q, Zhao L, Shi Y, Bai Y, Guo Z
Biological research 2023 Dec 2;56(1):62
Biological research 2023 Dec 2;56(1):62
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Wang Y, Chen X, Baker JS, Davison GW, Xu S, Zhou Y, Bao X
European journal of nutrition 2023 Apr;62(3):1453-1466
European journal of nutrition 2023 Apr;62(3):1453-1466
Combination of Perindopril Erbumine and Huangqi-Danshen Decoction Protects Against Chronic Kidney Disease via Sirtuin3/Mitochondrial Dynamics Pathway.
Wei X, Wang Y, Weng J, Lao Y, Deng R, Lu J, Yang S, Liu X
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5812105
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5812105
Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage.
Liao X, Lv X, Zhang Y, Han Y, Li J, Zeng J, Tang D, Meng J, Yuan X, Peng Z, Tao L, Xie Y
Oxidative medicine and cellular longevity 2022;2022:2453617
Oxidative medicine and cellular longevity 2022;2022:2453617
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Wang L, Wang J
Oxidative medicine and cellular longevity 2022;2022:1755608
Oxidative medicine and cellular longevity 2022;2022:1755608
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway.
Li Q, Tan JX, He Y, Bai F, Li SW, Hou YW, Ji LS, Gao YT, Zhang X, Zhou ZH, Yu Z, Fang M, Gao YQ, Li M
International journal of biological sciences 2022;18(4):1594-1611
International journal of biological sciences 2022;18(4):1594-1611
Atractylon inhibits the tumorigenesis of glioblastoma through SIRT3 signaling.
Sun S, Shi J, Wang X, Huang C, Huang Y, Xu J, Jiang Y, Cao L, Xie T, Wang Y, Huang Z
American journal of cancer research 2022;12(5):2310-2322
American journal of cancer research 2022;12(5):2310-2322
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Peng Y, Liao K, Tan F, Liang Y, Sun X, Cui Z, Ye B, Chen Z, Tang S, Chen J
Experimental eye research 2022 Sep;222:109158
Experimental eye research 2022 Sep;222:109158
Fraxinellone inhibits progression of glioblastoma via regulating the SIRT3 signaling pathway.
Shi J, Sun S, Xing S, Huang C, Huang Y, Wang Q, Xue X, Chen Z, Wang Y, Huang Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113416
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113416
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350
Nature communications 2022 Oct 26;13(1):6350
[Effects of Long-Term Ethanol Consumption on Learning-Memory Functions in Mice and the Mechanisms Involved].
Zhou J, Wu W, Ji LW, Li Q, Liang Y, Li T, Yang L
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2022 Nov;53(6):1049-1054
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2022 Nov;53(6):1049-1054
Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway.
Yao Y, Ren Z, Yang R, Mei Y, Dai Y, Cheng Q, Xu C, Xu X, Wang S, Kim KM, Noh JH, Zhu J, Zhao N, Liu YU, Mao G, Sima J
Cell & bioscience 2022 Nov 4;12(1):180
Cell & bioscience 2022 Nov 4;12(1):180
Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling.
Gao S, Yang Q, Liu Z, Kong W, Chen J, Li X, Peng Y, Bao M, Bian X, Zhang Y, Jiang Q, Li Z, Zhang Y, Yan F, Ye J
Clinical science (London, England : 1979) 2022 Nov 30;136(22):1711-1730
Clinical science (London, England : 1979) 2022 Nov 30;136(22):1711-1730
Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation.
Hou T, Tian Y, Cao Z, Zhang J, Feng T, Tao W, Sun H, Wen H, Lu X, Zhu Q, Li M, Lu X, Liu B, Zhao Y, Yang Y, Zhu WG
Molecular cell 2022 Nov 3;82(21):4099-4115.e9
Molecular cell 2022 Nov 3;82(21):4099-4115.e9
SIRT3-AMPK signaling pathway as a protective target in endothelial dysfunction of early sepsis.
Yu H, Liu Q, Chen G, Huang L, Luo M, Lv D, Luo S
International immunopharmacology 2022 May;106:108600
International immunopharmacology 2022 May;106:108600
Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.
Head PE, Myung S, Chen Y, Schneller JL, Wang C, Duncan N, Hoffman P, Chang D, Gebremariam A, Gucek M, Manoli I, Venditti CP
Science translational medicine 2022 May 25;14(646):eabn4772
Science translational medicine 2022 May 25;14(646):eabn4772
Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin-induced acute kidney injury.
Yu C, Li T, Li J, Cui B, Liu N, Bayliss G, Zhuang S
Journal of cellular and molecular medicine 2022 Jul;26(14):4061-4075
Journal of cellular and molecular medicine 2022 Jul;26(14):4061-4075
Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3.
Zhang Q, Ren J, Wang F, Pan M, Cui L, Li M, Qu F
Free radical biology & medicine 2022 Jul;187:1-16
Free radical biology & medicine 2022 Jul;187:1-16
The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3.
Chen DK, Shao HY, Yang L, Hu JM
Natural products and bioprospecting 2022 Jan 27;12(1):1
Natural products and bioprospecting 2022 Jan 27;12(1):1
The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells.
Fu X, Li K, Niu Y, Lin Q, Liang H, Luo X, Liu L, Li N
Microbiology spectrum 2022 Feb 23;10(1):e0231021
Microbiology spectrum 2022 Feb 23;10(1):e0231021
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Zhang S, Wu X, Wang J, Shi Y, Hu Q, Cui W, Bai H, Zhou J, Du Y, Han L, Li L, Feng D, Ge S, Qu Y
Redox biology 2022 Aug;54:102390
Redox biology 2022 Aug;54:102390
Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis.
Zhang L, Shi J, Du D, Niu N, Liu S, Yang X, Lu P, Shen X, Shi N, Yao L, Zhang R, Hu G, Lu G, Zhu Q, Zeng T, Liu T, Xia Q, Huang W, Xue J
EBioMedicine 2022 Apr;78:103959
EBioMedicine 2022 Apr;78:103959
Antimelanoma Effects of Concomitant Inhibition of SIRT1 and SIRT3 in Braf(V600E)/Pten(NULL) Mice.
Chhabra G, Singh CK, Guzmán-Pérez G, Ndiaye MA, Iczkowski KA, Ahmad N
The Journal of investigative dermatology 2022 Apr;142(4):1145-1157.e7
The Journal of investigative dermatology 2022 Apr;142(4):1145-1157.e7
Honokiol improves endothelial function in type 2 diabetic rats via alleviating oxidative stress and insulin resistance.
He A, Yu H, Hu Y, Chen H, Li X, Shen J, Zhuang R, Chen Y, Sasmita BR, Luo M, Lv D
Biochemical and biophysical research communications 2022 Apr 16;600:109-116
Biochemical and biophysical research communications 2022 Apr 16;600:109-116
The Protective Effect of 1,25(OH)(2)D(3) on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism.
Yang J, Zhang Y, Pan Y, Sun C, Liu Z, Liu N, Fu Y, Li X, Li Y, Kong J
Frontiers in cell and developmental biology 2021;9:627135
Frontiers in cell and developmental biology 2021;9:627135
Jian-Pi-Yi-Shen Formula Alleviates Chronic Kidney Disease in Two Rat Models by Modulating QPRT/NAD(+)/SIRT3/Mitochondrial Dynamics Pathway.
Liu X, Liu S, Zhang B, Luo D, Huang S, Wang F, Zheng L, Lu J, Chen J, Li S
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6625345
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6625345
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Lv D, Luo M, Cheng Z, Wang R, Yang X, Guo Y, Huang L, Li X, Huang B, Shen J, Luo S, Yan J
Oxidative medicine and cellular longevity 2021;2021:5577019
Oxidative medicine and cellular longevity 2021;2021:5577019
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Liu X, Luo D, Huang S, Liu S, Zhang B, Wang F, Lu J, Chen J, Li S
Frontiers in physiology 2021;12:723690
Frontiers in physiology 2021;12:723690
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Pan J, Cao Z, Fang C, Lei Y, Sun J, Huang X, Han D
Frontiers in pharmacology 2021;12:722530
Frontiers in pharmacology 2021;12:722530
Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects.
Liu X, Deng R, Wei X, Wang Y, Weng J, Lao Y, Lu J, Xiong G, Li S
Bioscience reports 2021 Oct 29;41(10)
Bioscience reports 2021 Oct 29;41(10)
Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.
Sivalingam K, Doke M, Khan MA, Samikkannu T
Scientific reports 2021 Oct 29;11(1):21335
Scientific reports 2021 Oct 29;11(1):21335
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
Sun XC, Wang Y, Zeng HF, Xi YM, Lin H, Han ZY, Chen KL
Cell death discovery 2021 Oct 21;7(1):304
Cell death discovery 2021 Oct 21;7(1):304
The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.
Yue XF, Shen CX, Wang JW, Dai LY, Fang Q, Long L, Zhi Y, Li XR, Wang YW, Shen GF, Liu ZJ, Shi CM, Li WB
Asian journal of andrology 2021 May-Jun;23(3):249-258
Asian journal of andrology 2021 May-Jun;23(3):249-258
CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice.
Gan L, Liu D, Liu J, Chen E, Chen C, Liu L, Hu H, Guan X, Ma W, Zhang Y, He Y, Liu B, Tang S, Jiang W, Xue J, Xin H
Signal transduction and targeted therapy 2021 Jun 11;6(1):223
Signal transduction and targeted therapy 2021 Jun 11;6(1):223
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3.
Yang X, Li X, Luo M, Li C, Huang L, Li X, Huang B, Shen J, Luo S, Yan J
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):897-907
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):897-907
Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels.
Gombos Z, Koltai E, Torma F, Bakonyi P, Kolonics A, Aczel D, Ditroi T, Nagy P, Kawamura T, Radak Z
International journal of molecular sciences 2021 Jul 15;22(14)
International journal of molecular sciences 2021 Jul 15;22(14)
Endurance Exercise-Induced Autophagy/Mitophagy Coincides with a Reinforced Anabolic State and Increased Mitochondrial Turnover in the Cortex of Young Male Mouse Brain.
Kwon I, Jang Y, Lee Y
Journal of molecular neuroscience : MN 2021 Jan;71(1):42-54
Journal of molecular neuroscience : MN 2021 Jan;71(1):42-54
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Yang W, Liu J, Hou L, Chen Q, Liu Y
Life sciences 2021 Jan 15;265:118796
Life sciences 2021 Jan 15;265:118796
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Cui W, Wu X, Shi Y, Guo W, Luo J, Liu H, Zheng L, Du Y, Wang P, Wang Q, Feng D, Ge S, Qu Y
Cell proliferation 2021 Feb;54(2):e12964
Cell proliferation 2021 Feb;54(2):e12964
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.
Chen H, Zhang DM, Zhang ZP, Li MZ, Wu HF
Genes & genomics 2021 Dec;43(12):1433-1444
Genes & genomics 2021 Dec;43(12):1433-1444
Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling.
Chen Y, Zhang H, Ji S, Jia P, Chen Y, Li Y, Wang T
Free radical biology & medicine 2021 Dec;177:1-14
Free radical biology & medicine 2021 Dec;177:1-14
Proteomic analysis of lysine acetylation reveals that metabolic enzymes and heat shock proteins may be potential targets for DSS-induced mice colitis.
Wang JM, Lin SR, Zhu YB, Yuan J, Wang YM, Zhang Q, Xie LS, Li SH, Liu SQ, Yu SG, Wu QF
International immunopharmacology 2021 Dec;101(Pt B):108336
International immunopharmacology 2021 Dec;101(Pt B):108336
Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3.
Cheng Z, Lv D, Luo M, Wang R, Guo Y, Yang X, Huang L, Li X, Li C, Shang FF, Huang B, Shen J, Luo S, Yan J
European journal of pharmacology 2021 Aug 15;905:174186
European journal of pharmacology 2021 Aug 15;905:174186
Dioscin Protects against Aβ1-42 Oligomers-Induced Neurotoxicity via the Function of SIRT3 and Autophagy.
Zhang Z, Han K, Wang C, Sun C, Jia N
Chemical & pharmaceutical bulletin 2020;68(8):717-725
Chemical & pharmaceutical bulletin 2020;68(8):717-725
Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy.
Zhu Z, Li H, Chen W, Cui Y, Huang A, Qi X
Frontiers in pharmacology 2020;11:94
Frontiers in pharmacology 2020;11:94
SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels.
Han D, Jiang L, Gu X, Huang S, Pang J, Wu Y, Yin J, Wang J
Journal of cellular physiology 2020 Nov;235(11):8839-8851
Journal of cellular physiology 2020 Nov;235(11):8839-8851
Anomalous AMPK-regulated angiotensin AT(1)R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.
Chao YM, Wu KLH, Tsai PC, Tain YL, Leu S, Lee WC, Chan JYH
Journal of biomedical science 2020 May 23;27(1):68
Journal of biomedical science 2020 May 23;27(1):68
SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity.
Feng X, Wang Y, Chen W, Xu S, Li L, Geng Y, Shen A, Gao H, Zhang L, Liu S
Aging 2020 Mar 4;12(5):4178-4192
Aging 2020 Mar 4;12(5):4178-4192
RGD-PEG-PLA Delivers MiR-133 to Infarct Lesions of Acute Myocardial Infarction Model Rats for Cardiac Protection.
Sun B, Liu S, Hao R, Dong X, Fu L, Han B
Pharmaceutics 2020 Jun 21;12(6)
Pharmaceutics 2020 Jun 21;12(6)
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Xu LX, Hao LJ, Ma JQ, Liu JK, Hasim A
Molecular and cellular biochemistry 2020 Jan;464(1-2):11-20
Molecular and cellular biochemistry 2020 Jan;464(1-2):11-20
Activated PI3K/AKT Signaling Pathway Associates with Oxidative Stress and Impaired Developmental Potential of Vitrified-Thawed Oocytes.
Li J, Yang X, Liu F, Song Y, Liu Y
Reproductive sciences (Thousand Oaks, Calif.) 2020 Jan;27(1):404-410
Reproductive sciences (Thousand Oaks, Calif.) 2020 Jan;27(1):404-410
Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice.
Téglás T, Ábrahám D, Jókai M, Kondo S, Mohammadi R, Fehér J, Szabó D, Wilhelm M, Radák Z
Biogerontology 2020 Dec;21(6):807-815
Biogerontology 2020 Dec;21(6):807-815
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Dong D, Dong Y, Fu J, Lu S, Yuan C, Xia M, Sun L
Life sciences 2020 Aug 15;255:117846
Life sciences 2020 Aug 15;255:117846
Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock.
Tong Y, Dong Y, Feng Y, Li Z, Jia Y, Zhang X, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2019;2019:4929107
Oxidative medicine and cellular longevity 2019;2019:4929107
Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells.
Fan C, Ma Q, Xu M, Qiao Y, Zhang Y, Li P, Bi Y, Tang M
International journal of molecular sciences 2019 Oct 5;20(19)
International journal of molecular sciences 2019 Oct 5;20(19)
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J
Pharmacological research 2019 Aug;146:104276
Pharmacological research 2019 Aug;146:104276
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
Sun Y, Teng Z, Sun X, Zhang L, Chen J, Wang B, Lu F, Liu N, Yu M, Peng S, Wang Y, Zhao D, Zhao Y, Ren H, Cheng Z, Dong S, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats.
Chen L, He PL, Yang J, Yang YF, Wang K, Amend B, Stenzl A, Zhang YM, Wang ZL, Xing SS, Luo X
Molecular medicine reports 2019 Apr;19(4):2960-2968
Molecular medicine reports 2019 Apr;19(4):2960-2968
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Yang Y, Cao Y, Chen L, Liu F, Qi Z, Cheng X, Wang Z
Cancer medicine 2018 Sep;7(9):4610-4618
Cancer medicine 2018 Sep;7(9):4610-4618
Modulation of mitochondrial phenotypes by endurance exercise contributes to neuroprotection against a MPTP-induced animal model of PD.
Jang Y, Kwon I, Song W, Cosio-Lima LM, Taylor S, Lee Y
Life sciences 2018 Sep 15;209:455-465
Life sciences 2018 Sep 15;209:455-465
Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration.
Song Y, Li S, Geng W, Luo R, Liu W, Tu J, Wang K, Kang L, Yin H, Wu X, Gao Y, Zhang Y, Yang C
Redox biology 2018 Oct;19:339-353
Redox biology 2018 Oct;19:339-353
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Xing SS, Li J, Chen L, Yang YF, He PL, Li J, Yang J
Mechanisms of ageing and development 2018 Oct;175:1-6
Mechanisms of ageing and development 2018 Oct;175:1-6
Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.
Xu WY, Hu QS, Qin Y, Zhang B, Liu WS, Ni QX, Xu J, Yu XJ
World journal of gastroenterology 2018 Nov 21;24(43):4893-4905
World journal of gastroenterology 2018 Nov 21;24(43):4893-4905
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
Sun Y, Tian Z, Liu N, Zhang L, Gao Z, Sun X, Yu M, Wu J, Yang F, Zhao Y, Ren H, Chen H, Zhao D, Wang Y, Dong S, Xu C, Lu F, Zhang W
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, Wei X, Zhang Y, Sun Y, Zhou Z, Su H, Zhang C, Li N, Gao C, Peng J, Yi F
Nature communications 2017 Sep 4;8(1):413
Nature communications 2017 Sep 4;8(1):413
Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia.
Zhou X, Han TL, Chen H, Baker PN, Qi H, Zhang H
Experimental cell research 2017 Oct 1;359(1):195-204
Experimental cell research 2017 Oct 1;359(1):195-204
Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity.
Yoon SP, Kim J
Anatomy & cell biology 2016 Sep;49(3):165-176
Anatomy & cell biology 2016 Sep;49(3):165-176
Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells.
Jiao X, Li Y, Zhang T, Liu M, Chi Y
Biochemical and biophysical research communications 2016 Nov 18;480(3):387-393
Biochemical and biophysical research communications 2016 Nov 18;480(3):387-393
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SIRT3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIRT3. This antibody recognizes human,mouse,rat antigen. The SIRT3 antibody has been validated for the following applications: ELISA, WB analysis.