Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [203]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10099-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10099-1-AP, RRID:AB_2239240
- Product name
- SIRT3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SIRT3 antibody (Cat. #10099-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury.
SIRT3 promotes oxaliplatin sensitivity in hepatocellular carcinoma by promoting ferroptosis through endoplasmic reticulum stress response.
NRH attenuates age-related hearing loss by suppressing cochlear ferroptosis and cellular senescence via Sirt3 activation.
Lithospermic Acid Improves Doxorubicin-Induced Cardiomyopathy Through Sirtuin-3-Mediated Deacetylation of p53.
Icariin attenuates premature ovarian insufficiency via a phytoestrogenic mechanism mediated by the ERβ/SIRT3 pathway.
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promoting SIRT1/SIRT3/FOXO3a-Dependent Mitochondrial Quality Control.
High-Intensity Interval Training Outperforms Moderate-Intensity Exercise in Hyperlipidemic ApoE⁻/⁻ Mice: A Molecular and Histological Comparison.
Hyperacetylation escalates myocardial susceptibility to ischemia reperfusion injury by mediating mitochondrial supercomplexes assembly in T2DM.
Benzalkonium chlorides compromise oocyte maturation and developmental competence by disrupting mitochondrial function and the SIRT3-SOD2 antioxidant axis.
High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE(‑/‑) mice via the NAD(+)‑mediated SIRT1/MFN2 pathway.
Paeoniflorin Ameliorates Spinal Cord Injury by Controlling Apoptosis and Ferroptosis in H(2)O(2)-Damaged PC12 Cells.
Combining Network Pharmacology and Experimental Verification to Investigate the Protective Effect of Melatonin on Fluoride-Induced Brain Injury.
KRAS(G12D) mutation promotes pancreatic tumorigenesis by suppressing sirtuin three via the guanine nucleotide exchange factor RCC1.
Zinc Alleviates Oxidative Stress Injury of the Testis Induced by Zearalenone through Sirt3-Foxo3 Pathway in Mice.
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
[Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress].
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy.
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polarization via mitophagy.
Circadian rhythm disruption impairs ovarian follicular development via NAD(+) metabolic reprogramming.
SIRT3-mediated mitochondrial fatty acid oxidation protects against hepatic lipid deposition in fatty liver hemorrhagic syndrome.
Quantitative evaluation of therapeutic effect of silver needle thermal conduction therapy on myofascial trigger point.
Improved myocardial mitochondrial energy metabolism in rats with chronic heart failure by modifying fatty acid oxidation using an extract of sand-fired aconite (Jianchang gang processing).
Sestrin2 Regulates Mitochondrial Function and Autophagy via Nrf2/SIRT3 Signaling to Ameliorate Hypoxia/Reoxygenation-Induced Rat's Cardiomyocyte Injury.
H3K18 lactylation drives the progression of silica nanoparticles-induced pulmonary fibrosis via promoting macrophage M1 polarization.
Cationic microbubble loading hSIRT3 and hTIMP3 optimize cardiac-targeted delivery and myocardial protection in the porcine MI/R model.
Seeds-and-soil inspired hydrogel microspheres: A dual-action antioxidant and cellular therapy for reversing intervertebral disc degeneration.
TNALP promotes epithelial oxidative stress and fibrosis via SIRT3-dependent mechanisms in tracheal injury.
SIRT3 mediates Tubeimoside I's inhibition on pulmonary artery smooth muscle cell proliferation and oxidative stress in pulmonary arterial hypertension.
Aronia melanocarpa anthocyanins attenuate light-induced retinal damage by enhancing photoreceptor cell function and anti-inflammatory effects.
Vitamin K2 Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease Through Mitochondrial Dysfunction Modulation via Gut Microbiota.
Activation of Sirtuin3 by 6,4'-Dihydroxy-7-methoxyflavanone Against Myoblasts Senescence by Attenuating D-Galactose-Induced Oxidative Stress and Inflammation.
The Sirt3-CD38 axis induces mitochondrial dysfunction in hypertrophied heart by regulating mitochondrial calcium overload.
Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis.
Mitochondrial dysfunction-associated cellular senescence is partially involved in bleomycin-induced pulmonary fibrosis in mice.
SIRT3 deficiency aggravates mitochondrial metabolic disorder and podocyte injury in DKD via MPC2 acetylation.
Ailanthone targets mitophagy-loaded SIRT4 to facilitate the deacetylation of HIF1α, triggering oxidative stress for gastric carcinoma treatment.
SIRT3-activating, biodegradable poly-honokiol with high drug loading for thoracic aortic dissection therapy.
SIRT3 mitigates dry eye disease through the activation of autophagy by deacetylation of FOXO1.
SIRT3 Functions as an Eraser of Histone H3K9 Lactylation to Modulate Transcription for Inhibiting the Progression of Esophageal Cancer.
Effective compound combination of Bufei Yishen formula ameliorates PM2.5-induced COPD by inhibiting mitochondrial oxidative stress through SIRT3-mediated FOXO3 deacetylation.
Lycium barbarum glycopeptide attenuates intracerebral hemorrhage-induced inflammation and oxidative stress via activation of the Sirt3 signaling pathway.
Conjugation with the XJB peptide enhanced neuroprotective effect of honokiol via SIRT3 modulation.
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Erucin Alleviates Cardiac Hypertrophy by Improving Mitochondrial Function via Nrf2-Sirt3 Pathway.
HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma.
Mitochondrial oxidative stress inhibited Sirt3/Foxo3/PPARα pathway and aggravated copper and zinc co-deficiency-induced hepatic lipotoxicity in a fish model.
Mitochondrial Calcium Uniporter-Mediated Regulation of the SIRT3/GSK3β/β-Catenin Signaling Pathway in Vascular Remodeling.
Alleviation of fibrosis and oxidative stress in pressure overload-induced cardiac remodeling and heart failure via SIRT3 activation by colchicine.
Long-Term Administration of Nicotinamide Mononucleotide Mitigates High-Fat-Diet-Induced Physiological Decline in Aging Mice.
The SIRT6/BAP1/xCT signaling axis mediates ferroptosis in cisplatin-induced AKI.
Chemoprotective Mechanism of Sodium Thiosulfate Against Cisplatin-Induced Nephrotoxicity Is via Renal Hydrogen Sulfide, Arginine/cAMP and NO/cGMP Signaling Pathways.
Shenling Baizhu San improves spermatogenic dysfunction in hyperuricemia mice by regulating Sirt3/Nrf2 to inhibit testicular ferroptosis.
Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis.
Trehalose Inhibits ferroptosis Through Activating SIRT3/SOD2 Signaling Axis and Alleviates Brain Injury After Traumatic Brain Injury.
Hydroxyacyl-coenzyme A dehydrogenase: A biomarker for authentication of death from mechanical asphyxia.
OAB-14 alleviates mitochondrial impairment through the SIRT3-dependent mechanism in APP/PS1 transgenic mice and N2a/APP cells.
Porphyromonas gingivalis Induces Endothelial Dysfunction Through Sirt3-Dependent CypD Acetylation.
SIRT5 Facilitates Liver Steatosis Progression via Promoting SDH Desuccinylation During High-Fat Diet Feeding.
Atractylodin inhibits ferroptosis in sepsis‑induced acute gastrointestinal injury via SIRT3/PRDX3.
Fisetin carbon dots alleviate periodontitis by enhancing mitophagy through regulation of sirtuin 3 SUMOylation.
Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis.
Sirtuin 1-mediated recruitment of non-structural protein 1 to glucocorticoid receptor induces glucocorticoid insensitivity post RSV infection.
Hesperidin mitigates copper nanoparticle exposure-induced mitochondrial unfolded protein response through the SIRT3-FOXO3A signaling pathway.
NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway.
MRPL12 K163 acetylation inhibits ccRCC via driving mitochondrial metabolic reprogramming.
SIRT3 Acetylation Regulates Mitophagy to Alleviate Deoxynivalenol-Induced Apoptosis in Porcine Alveolar Macrophages Cells.
The protective effect of kaempferol on high glucose-stimulated renal tubular epithelial cells.
Curcumin preserves bone health compromised by diabetes by inhibiting osteoporosis through regulation of the SIRT3/FoxO3a signalling pathway.
Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein.
Semaglutide protects against diabetes-associated cardiac inflammation via Sirt3-dependent RKIP pathway.
Xin-Ji-Er-Kang balances mitochondrial fusion and fission to protect cardiomyocytes in mice with heart failure by regulating the ERα/SIRT3 pathway.
Surfactant protein D alleviates chondrocytes senescence by upregulating SIRT3/SOD2 pathway in osteoarthritis.
Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway.
Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway.
Integrated analysis reveals crosstalk between pyroptosis and immune regulation in renal fibrosis.
Capsaicin mitigates ventilator-induced lung injury by suppressing ferroptosis and maintaining mitochondrial redox homeostasis through SIRT3-dependent mechanisms.
Deacetylation of GLUD1 maintains the survival of lung adenocarcinoma cells under glucose starvation by inhibiting autophagic cell death.
Dapagliflozin attenuates AKI to CKD transition in diabetes by activating SIRT3/PGC1-α signaling and alleviating aberrant metabolic reprogramming.
Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis.
SIRT3 Inhibits Cell Proliferation of Nonsmall Cell Lung Carcinoma by Inducing ROS Production.
Sirt6 Mono-ADP-Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission.
Metformin improves HPRT1-targeted purine metabolism and repairs NR4A1-mediated autophagic flux by modulating FoxO1 nucleocytoplasmic shuttling to treat postmenopausal osteoporosis.
SIRT3 differentially regulates lysine benzoylation from SIRT2 in mammalian cells.
Resveratrol protects against myocardial ischemic injury in obese mice via activating SIRT3/FOXO3a signaling pathway and restoring redox homeostasis.
Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis.
Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway.
Phosphatidylserine Counteracts the High Stocking Density-Induced Stress Response, Redox Imbalance and Immunosuppression in Fish Megalobrama ambylsephala.
The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia-reperfusion-induced renal fibrosis.
KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.
Corn Oligopeptide Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Sirtuin Signaling Pathway.
The Effectiveness of Four Nicotinamide Adenine Dinucleotide (NAD(+)) Precursors in Alleviating the High-Glucose-Induced Damage to Hepatocytes in Megalobrama amblycephala: Evidence in NAD(+) Homeostasis, Sirt1/3 Activation, Redox Defense, Inflammatory Response, Apoptosis, and Glucose Metabolism.
Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.
PGC1-Alpha/Sirt3 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Hirudin by Inhibiting Fibroblast Senescence.
Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy.
The Selective SIRT3 Inhibitor 3-TYP Represses Primary Myeloma Growth by Reducing c-Myc Stability.
Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity.
Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model.
Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia.
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice.
Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.
Ruscogenin attenuates osteoarthritis by modulating oxidative stress-mediated macrophage reprogramming via directly targeting Sirt3.
Dihydrolipoyl dehydrogenase promotes white adipocytes browning by activating the RAS/ERK pathway and undergoing crotonylation modification.
Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.
Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3.
Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway.
Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway.
Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway.
SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages.
Metabolic reprogramming induced by DCA enhances cisplatin sensitivity through increasing mitochondrial oxidative stress in cholangiocarcinoma.
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity.
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis.
Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling.
Bioactivity-based molecular networking-guided identification of guttiferone J from Garcinia cambogia as an anti-obesity candidate.
Effects of Exercise Preconditioning on Doxorubicin-Induced Liver and Kidney Toxicity in Male and Female Rats.
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Resveratrol reverses TGF-β1-mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis.
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics.
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated m(6)A modification of SIRT3 mRNA.
Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models.
SIRT3 Regulates Levels of Deacetylated SOD2 to Prevent Oxidative Stress and Mitochondrial Dysfunction During Oocyte Maturation in Pigs.
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Combination of Perindopril Erbumine and Huangqi-Danshen Decoction Protects Against Chronic Kidney Disease via Sirtuin3/Mitochondrial Dynamics Pathway.
Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage.
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway.
Mitochonic Acid-5 Inhibits Reactive Oxygen Species Production and Improves Human Chondrocyte Survival by Upregulating SIRT3-Mediated, Parkin-dependent Mitophagy.
Atractylon inhibits the tumorigenesis of glioblastoma through SIRT3 signaling.
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Fraxinellone inhibits progression of glioblastoma via regulating the SIRT3 signaling pathway.
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
[Effects of Long-Term Ethanol Consumption on Learning-Memory Functions in Mice and the Mechanisms Involved].
Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway.
Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling.
Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation.
SIRT3-AMPK signaling pathway as a protective target in endothelial dysfunction of early sepsis.
Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.
Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin-induced acute kidney injury.
Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3.
The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3.
The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells.
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis.
Antimelanoma Effects of Concomitant Inhibition of SIRT1 and SIRT3 in Braf(V600E)/Pten(NULL) Mice.
Honokiol improves endothelial function in type 2 diabetic rats via alleviating oxidative stress and insulin resistance.
The Protective Effect of 1,25(OH)(2)D(3) on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism.
Jian-Pi-Yi-Shen Formula Alleviates Chronic Kidney Disease in Two Rat Models by Modulating QPRT/NAD(+)/SIRT3/Mitochondrial Dynamics Pathway.
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects.
Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.
CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice.
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3.
Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels.
Endurance Exercise-Induced Autophagy/Mitophagy Coincides with a Reinforced Anabolic State and Increased Mitochondrial Turnover in the Cortex of Young Male Mouse Brain.
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.
Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling.
Proteomic analysis of lysine acetylation reveals that metabolic enzymes and heat shock proteins may be potential targets for DSS-induced mice colitis.
Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3.
Dioscin Protects against Aβ1-42 Oligomers-Induced Neurotoxicity via the Function of SIRT3 and Autophagy.
Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy.
SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels.
Anomalous AMPK-regulated angiotensin AT(1)R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.
SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity.
RGD-PEG-PLA Delivers MiR-133 to Infarct Lesions of Acute Myocardial Infarction Model Rats for Cardiac Protection.
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Activated PI3K/AKT Signaling Pathway Associates with Oxidative Stress and Impaired Developmental Potential of Vitrified-Thawed Oocytes.
Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock.
Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats.
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Modulation of mitochondrial phenotypes by endurance exercise contributes to neuroprotection against a MPTP-induced animal model of PD.
Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration.
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia.
Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity.
Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells.
Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.
Yao M, Wang X, Wei H, Wang L, Zhang D, Liang Z, He R, He Y, Jiang L, Cui Y
Frontiers in pharmacology 2026;17:1716078
Frontiers in pharmacology 2026;17:1716078
SIRT3 promotes oxaliplatin sensitivity in hepatocellular carcinoma by promoting ferroptosis through endoplasmic reticulum stress response.
Xu Y, Ma C, Xu X, Tu J, Chen X, Yang X, Sun D, Liu S, Wan Y, Qin L, Gu W, Qian H
Pathology, research and practice 2026 May;281:156400
Pathology, research and practice 2026 May;281:156400
NRH attenuates age-related hearing loss by suppressing cochlear ferroptosis and cellular senescence via Sirt3 activation.
Yuan C, Feng C, Ma T, Li S, Liu M, Tang G, Han L, Xing Y, Zhang T
Free radical biology & medicine 2026 May;248:450-468
Free radical biology & medicine 2026 May;248:450-468
Lithospermic Acid Improves Doxorubicin-Induced Cardiomyopathy Through Sirtuin-3-Mediated Deacetylation of p53.
Zhao Y, Xu T, Ye C, Zhang K, Heng X, Huang S, Chen Y, Guo Y, Shao S, Wen Z, Shao C, Lu X, Sun N, Yang H
Phytotherapy research : PTR 2026 Mar;40(3):965-985
Phytotherapy research : PTR 2026 Mar;40(3):965-985
Icariin attenuates premature ovarian insufficiency via a phytoestrogenic mechanism mediated by the ERβ/SIRT3 pathway.
Yang J, Wang N, Tong S, Zhao P
Cellular signalling 2026 Mar;139:112334
Cellular signalling 2026 Mar;139:112334
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promoting SIRT1/SIRT3/FOXO3a-Dependent Mitochondrial Quality Control.
Gao L, Shen J, Gao J, Li T, Yan D, Zeng X, Meng J, Li H, Chen D, Wu J
Antioxidants (Basel, Switzerland) 2026 Mar 23;15(3)
Antioxidants (Basel, Switzerland) 2026 Mar 23;15(3)
High-Intensity Interval Training Outperforms Moderate-Intensity Exercise in Hyperlipidemic ApoE⁻/⁻ Mice: A Molecular and Histological Comparison.
Qian C, Pei Z, Yang Z, Sun M, Zhang Y, Liu H, Sun Y
Frontiers in bioscience (Landmark edition) 2026 Mar 20;31(3):47751
Frontiers in bioscience (Landmark edition) 2026 Mar 20;31(3):47751
Hyperacetylation escalates myocardial susceptibility to ischemia reperfusion injury by mediating mitochondrial supercomplexes assembly in T2DM.
Deng Y, Yang W, Yang J, Ji L, Xie M, Tang K, He Q, Hu G, Shangguan W, Jiang C, Li T
Redox biology 2026 Jun;93:104163
Redox biology 2026 Jun;93:104163
Benzalkonium chlorides compromise oocyte maturation and developmental competence by disrupting mitochondrial function and the SIRT3-SOD2 antioxidant axis.
Lay K, Zhang D, Wang H, Li M, Zhang Y, Xu Q, Jia B, Nguyen T, Ren C, Zhou X, Tang H, Ling Y, Wu M, Gao Y, Zhang M, Zhang Y
Animal reproduction science 2026 Jun;289:108163
Animal reproduction science 2026 Jun;289:108163
High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE(‑/‑) mice via the NAD(+)‑mediated SIRT1/MFN2 pathway.
Gao S, Yao W, Yang J, Liu Y, Pei Z
Molecular medicine reports 2026 Jan;33(1)
Molecular medicine reports 2026 Jan;33(1)
Paeoniflorin Ameliorates Spinal Cord Injury by Controlling Apoptosis and Ferroptosis in H(2)O(2)-Damaged PC12 Cells.
Zhang Z, Zhou Z, Zhang P, Huo Y
Immunity, inflammation and disease 2026 Jan;14(1):e70324
Immunity, inflammation and disease 2026 Jan;14(1):e70324
Combining Network Pharmacology and Experimental Verification to Investigate the Protective Effect of Melatonin on Fluoride-Induced Brain Injury.
Ma R, Wang C, Qin W, Li Y, Zhang M, Liang Y, Wang L, Wang S, Xie G, Niu Q
Toxics 2026 Jan 29;14(2)
Toxics 2026 Jan 29;14(2)
KRAS(G12D) mutation promotes pancreatic tumorigenesis by suppressing sirtuin three via the guanine nucleotide exchange factor RCC1.
Mai T, Wang M, Qiu Y, Lu W, Wu H, Chen S, Chiao PJ, Huang P
The Journal of biological chemistry 2026 Feb;302(2):111057
The Journal of biological chemistry 2026 Feb;302(2):111057
Zinc Alleviates Oxidative Stress Injury of the Testis Induced by Zearalenone through Sirt3-Foxo3 Pathway in Mice.
Zhao Z, Yao J, Guo Z, Song L, Ma J, Song Y, Ma Y, Zhao J
Biological trace element research 2026 Feb;204(2):769-785
Biological trace element research 2026 Feb;204(2):769-785
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Fu T, Sun S, Wang Z, Zhao F, Zhen J, Ji X, Xue F, Mu Q, Wang Y, Liu Y, Wan Q
Cardiovascular diabetology 2026 Feb 3;25(1)
Cardiovascular diabetology 2026 Feb 3;25(1)
[Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress].
Peng Y, Jiang Y, Ma D, He A, Lü D, Luo M, Luo S
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2026 Feb 20;46(2):316-324
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2026 Feb 20;46(2):316-324
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy.
Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y, Ni Q, Ding X, Song G
Journal of diabetes 2026 Apr;18(4):e70209
Journal of diabetes 2026 Apr;18(4):e70209
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polarization via mitophagy.
You T, Dai B, Ding X, He Z, Peng J, Tao S, Ye L, Song T, Fan Z, Chen N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157985
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157985
Circadian rhythm disruption impairs ovarian follicular development via NAD(+) metabolic reprogramming.
Ying YY, Chen X, Yao SY, Chen RX, Ying Y, Qiu H, Xu QQ, Li ZY, Ye CQ, Qian YL, Liang HQ, Sun X, Zhang D
EBioMedicine 2026 Apr;126:106200
EBioMedicine 2026 Apr;126:106200
SIRT3-mediated mitochondrial fatty acid oxidation protects against hepatic lipid deposition in fatty liver hemorrhagic syndrome.
Cao P, Chen J, Zeng C, Hu Y, Yuan J, Guo X, Cao H, Zhang C, Zhuang Y, Hu G
Poultry science 2026 Apr 7;105(7):106901
Poultry science 2026 Apr 7;105(7):106901
Quantitative evaluation of therapeutic effect of silver needle thermal conduction therapy on myofascial trigger point.
Qin Y, Wang Y, Wo C, Wang Z, Yu Z, Huang Y, Wang L
PloS one 2025;20(9):e0330592
PloS one 2025;20(9):e0330592
Improved myocardial mitochondrial energy metabolism in rats with chronic heart failure by modifying fatty acid oxidation using an extract of sand-fired aconite (Jianchang gang processing).
Zhang H, Huang Y, Yang S, Gong F, Gu Y, Xie Q, Ye Y, Lu X, Zhong L
Frontiers in pharmacology 2025;16:1600410
Frontiers in pharmacology 2025;16:1600410
Sestrin2 Regulates Mitochondrial Function and Autophagy via Nrf2/SIRT3 Signaling to Ameliorate Hypoxia/Reoxygenation-Induced Rat's Cardiomyocyte Injury.
Liu T, Kong J, Li Z, Xi S, Liu L
Drug development research 2025 Sep;86(6):e70150
Drug development research 2025 Sep;86(6):e70150
H3K18 lactylation drives the progression of silica nanoparticles-induced pulmonary fibrosis via promoting macrophage M1 polarization.
Shi L, Zhang L, Ma Z, Hu Z, Geng Z, Liu H, Wang J, Feng K, Geng Y, Liu Y, Zhang C, Xie Y, Zou M, Liu Q, Yang Z, Pang Y, Niu Y, Bao L, Zhang R
Journal of hazardous materials 2025 Sep 15;496:139286
Journal of hazardous materials 2025 Sep 15;496:139286
Cationic microbubble loading hSIRT3 and hTIMP3 optimize cardiac-targeted delivery and myocardial protection in the porcine MI/R model.
Cai P, Chen K, Qin X, Jiang X, Jiao X, Liu K, Guo E, Li Z, Qiu X, Liu C, Sun L, Chuai J, Wu J, Chen W, Tian H
Materials today. Bio 2025 Oct;34:102234
Materials today. Bio 2025 Oct;34:102234
Seeds-and-soil inspired hydrogel microspheres: A dual-action antioxidant and cellular therapy for reversing intervertebral disc degeneration.
Yang Y, Guo J, Cao H, Tian X, Shen H, Niu J, Yang H, Shi Q, Xu Y
Biomaterials 2025 Oct;321:123326
Biomaterials 2025 Oct;321:123326
TNALP promotes epithelial oxidative stress and fibrosis via SIRT3-dependent mechanisms in tracheal injury.
Liu Z, Peng H, Peng M, Liao J, Liu B, Zhuang R, Yang H, Xu L, Li Y, Gao L, Guo S
Cellular signalling 2025 Oct;134:111943
Cellular signalling 2025 Oct;134:111943
SIRT3 mediates Tubeimoside I's inhibition on pulmonary artery smooth muscle cell proliferation and oxidative stress in pulmonary arterial hypertension.
Li Y, Zhang Y, Chen Y, Qiao Z, Wang D, Yang Y, Huang W, Yan J
European journal of pharmacology 2025 Oct 5;1004:177938
European journal of pharmacology 2025 Oct 5;1004:177938
Aronia melanocarpa anthocyanins attenuate light-induced retinal damage by enhancing photoreceptor cell function and anti-inflammatory effects.
Ye M, Zuo L, Li X, Sun D, Xu X, Huang S, Bai W
Food & function 2025 Oct 27;16(21):8496-8514
Food & function 2025 Oct 27;16(21):8496-8514
Vitamin K2 Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease Through Mitochondrial Dysfunction Modulation via Gut Microbiota.
Wang W, Li J, Mu L, Bai Y, Zhu M, Zhao Y, Hu S, Wang J, Shao P, Su X
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2025 Oct 23;95(5):37275
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2025 Oct 23;95(5):37275
Activation of Sirtuin3 by 6,4'-Dihydroxy-7-methoxyflavanone Against Myoblasts Senescence by Attenuating D-Galactose-Induced Oxidative Stress and Inflammation.
Li B, Gu Y, Zhou L, Chen R, Liu Y, Wan Z, Liang Z, Wang Y, Ji R, Liu Z
Nutrients 2025 Oct 20;17(20)
Nutrients 2025 Oct 20;17(20)
The Sirt3-CD38 axis induces mitochondrial dysfunction in hypertrophied heart by regulating mitochondrial calcium overload.
Liu J, Liu N, Qi C, Dong D, Liu B
European journal of medical research 2025 Oct 14;30(1):967
European journal of medical research 2025 Oct 14;30(1):967
Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis.
Hu Y, Lu H, Fang H, Chen B, Chen Z, Jiang M, Zhou Y, Li Z, Gao S, Huang Z, Zhou C, Liu Y, Chen Z, Fan Y
International journal of surgery (London, England) 2025 Oct 1;111(10):6647-6662
International journal of surgery (London, England) 2025 Oct 1;111(10):6647-6662
Mitochondrial dysfunction-associated cellular senescence is partially involved in bleomycin-induced pulmonary fibrosis in mice.
Yao YX, Lu X, Li Z, Liao HY, Liu ZB, Zhao H, Wang H, Xu DX, Tan ZX
Toxicology and applied pharmacology 2025 Nov;504:117524
Toxicology and applied pharmacology 2025 Nov;504:117524
SIRT3 deficiency aggravates mitochondrial metabolic disorder and podocyte injury in DKD via MPC2 acetylation.
Feng J, Feng L, Yan Y, Ye H, Tang K, Guo X, Ma Y
Cellular signalling 2025 Nov;135:112029
Cellular signalling 2025 Nov;135:112029
Ailanthone targets mitophagy-loaded SIRT4 to facilitate the deacetylation of HIF1α, triggering oxidative stress for gastric carcinoma treatment.
Lian X, Dai M, Xu X, Zhao H, Li S, Liu X, Lian Y, Ma T, Lian X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157283
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157283
SIRT3-activating, biodegradable poly-honokiol with high drug loading for thoracic aortic dissection therapy.
Qiao X, Wang D, Zhu H, Zhang B, Sun H, Wang J, Tan G, Jiang L, Peng X, Zhang L, Wang L, Han S, Meng L, Duan W
Journal of advanced research 2025 Nov 14;
Journal of advanced research 2025 Nov 14;
SIRT3 mitigates dry eye disease through the activation of autophagy by deacetylation of FOXO1.
Zhang D, Liang Q, Jiang J, Liu W, Chu Y, Chen Z, Li B, Chen T, Tsao JR, Hu K
Experimental eye research 2025 May;254:110328
Experimental eye research 2025 May;254:110328
SIRT3 Functions as an Eraser of Histone H3K9 Lactylation to Modulate Transcription for Inhibiting the Progression of Esophageal Cancer.
Chen C, Zhang Y, Zang Y, Fan Z, Han Y, Bai X, Wang A, Zhang J, Wang J, Zhang K
Molecular & cellular proteomics : MCP 2025 May;24(5):100973
Molecular & cellular proteomics : MCP 2025 May;24(5):100973
Effective compound combination of Bufei Yishen formula ameliorates PM2.5-induced COPD by inhibiting mitochondrial oxidative stress through SIRT3-mediated FOXO3 deacetylation.
Wang J, Yue H, Dong Y, Liu T, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156568
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156568
Lycium barbarum glycopeptide attenuates intracerebral hemorrhage-induced inflammation and oxidative stress via activation of the Sirt3 signaling pathway.
Ma CS, Han B, Meng SC, Bai M, Yi WJ, Zhang LY, Duan MY, Wang YJ, He MT
International immunopharmacology 2025 May 8;154:114518
International immunopharmacology 2025 May 8;154:114518
Conjugation with the XJB peptide enhanced neuroprotective effect of honokiol via SIRT3 modulation.
Liu G, Zhang T, Qian S, Zhang X, Lou H, Fan P
European journal of medicinal chemistry 2025 May 5;289:117460
European journal of medicinal chemistry 2025 May 5;289:117460
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Lin J, Yin Y, Cao J, Zhang Y, Chen J, Chen R, Zou B, Huang C, Lv Y, Xu S, Yang H, Lin P, Xie D
Cell discovery 2025 May 28;11(1):52
Cell discovery 2025 May 28;11(1):52
Erucin Alleviates Cardiac Hypertrophy by Improving Mitochondrial Function via Nrf2-Sirt3 Pathway.
Jiang S, Wang C, Dong Y, Chen L, Shi M, Zhang F, Wang Z, Liang M
Phytotherapy research : PTR 2025 May 26;
Phytotherapy research : PTR 2025 May 26;
HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma.
Zhou P, Peng X, Zhang K, Cheng J, Tang M, Shen L, Zhou Q, Li D, Yang L
Cell death & disease 2025 Mar 6;16(1):160
Cell death & disease 2025 Mar 6;16(1):160
Mitochondrial oxidative stress inhibited Sirt3/Foxo3/PPARα pathway and aggravated copper and zinc co-deficiency-induced hepatic lipotoxicity in a fish model.
Zhong CC, Zhang X, Pantopoulos K, Song CC, Yang H, Wei XL, Luo Z
Cellular and molecular life sciences : CMLS 2025 Jun 5;82(1):226
Cellular and molecular life sciences : CMLS 2025 Jun 5;82(1):226
Mitochondrial Calcium Uniporter-Mediated Regulation of the SIRT3/GSK3β/β-Catenin Signaling Pathway in Vascular Remodeling.
Jiang M, Lin L, Yue S, Shi S, Yan H, Yi H, Han F, Xu S, Su J, Zhang R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70761
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70761
Alleviation of fibrosis and oxidative stress in pressure overload-induced cardiac remodeling and heart failure via SIRT3 activation by colchicine.
Wu M, Chen G, Peng Y, Luo S
Biochemical and biophysical research communications 2025 Jul 12;770:151957
Biochemical and biophysical research communications 2025 Jul 12;770:151957
Long-Term Administration of Nicotinamide Mononucleotide Mitigates High-Fat-Diet-Induced Physiological Decline in Aging Mice.
Zhou AJ, Xiong ZE, Wang L, Chen XX, Wang ZP, Zhang YD, Chen WW, Cai XL, Xu YL, Rong S, Wang T
The Journal of nutrition 2025 Jan;155(1):237-249
The Journal of nutrition 2025 Jan;155(1):237-249
The SIRT6/BAP1/xCT signaling axis mediates ferroptosis in cisplatin-induced AKI.
Yang S, Chen L, Din S, Ye Z, Zhou X, Cheng F, Li W
Cellular signalling 2025 Jan;125:111479
Cellular signalling 2025 Jan;125:111479
Chemoprotective Mechanism of Sodium Thiosulfate Against Cisplatin-Induced Nephrotoxicity Is via Renal Hydrogen Sulfide, Arginine/cAMP and NO/cGMP Signaling Pathways.
Dugbartey GJ, Alornyo KK, Adams I, Adjei S, Amoah D, Obeng-Kyeremeh R
International journal of molecular sciences 2025 Jan 4;26(1)
International journal of molecular sciences 2025 Jan 4;26(1)
Shenling Baizhu San improves spermatogenic dysfunction in hyperuricemia mice by regulating Sirt3/Nrf2 to inhibit testicular ferroptosis.
Jiang X, Yu X, Zhu Z, Lyu Y, Jiang X, Liu Z, Cao J, Xiao M
Journal of ethnopharmacology 2025 Jan 31;340:119310
Journal of ethnopharmacology 2025 Jan 31;340:119310
Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis.
Fan Y, Chen Z, Wang H, Jiang M, Lu H, Wei Y, Hu Y, Mo L, Liu Y, Zhou C, He W, Chen Z
Bone research 2025 Jan 26;13(1):18
Bone research 2025 Jan 26;13(1):18
Trehalose Inhibits ferroptosis Through Activating SIRT3/SOD2 Signaling Axis and Alleviates Brain Injury After Traumatic Brain Injury.
Mu Z, Sun Z, Wu S, Yang J, Wang P, Zhao X
Neurochemical research 2025 Jan 11;50(1):78
Neurochemical research 2025 Jan 11;50(1):78
Hydroxyacyl-coenzyme A dehydrogenase: A biomarker for authentication of death from mechanical asphyxia.
Wu T, Li W, Hu Y, Zhang D, Tian L, Xu H, Zhang F, Xiao B, Shi Y, Chen Y, Liao X, Ma K, Chen L
Forensic science international 2025 Feb;367:112371
Forensic science international 2025 Feb;367:112371
OAB-14 alleviates mitochondrial impairment through the SIRT3-dependent mechanism in APP/PS1 transgenic mice and N2a/APP cells.
Zheng N, Cao RL, Liu DY, Liu P, Zhao XY, Zhang SX, Huang M, Zheng ZH, Chen GL, Zou LB
Free radical biology & medicine 2025 Feb 16;228:360-378
Free radical biology & medicine 2025 Feb 16;228:360-378
Porphyromonas gingivalis Induces Endothelial Dysfunction Through Sirt3-Dependent CypD Acetylation.
Xu S, Zheng C, Huang J, Lu B, Que H, Xu L, Hou Y, He L, Fan X, Deng K, Hu R, Deng H, Wang Y
Journal of periodontal research 2025 Dec;60(12):1296-1307
Journal of periodontal research 2025 Dec;60(12):1296-1307
SIRT5 Facilitates Liver Steatosis Progression via Promoting SDH Desuccinylation During High-Fat Diet Feeding.
Liu Z, Hu J, Lin Y, Ge C, Shao Y, Bao M, Liu M, Jia S, Li Y, Xu X, Li R, Jiang Q, Yan F, Xiao F, Ye J
Liver international : official journal of the International Association for the Study of the Liver 2025 Dec;45(12):e70433
Liver international : official journal of the International Association for the Study of the Liver 2025 Dec;45(12):e70433
Atractylodin inhibits ferroptosis in sepsis‑induced acute gastrointestinal injury via SIRT3/PRDX3.
Hu YX, Chen MQ, Wang JL, Wu T, Zhang HD, Li TT, Gao H, Bai Y
Molecular medicine reports 2025 Dec;32(6)
Molecular medicine reports 2025 Dec;32(6)
Fisetin carbon dots alleviate periodontitis by enhancing mitophagy through regulation of sirtuin 3 SUMOylation.
Deng Y, Jiang X, Che Z, Shang Y, Hu M, Wang W, Yu W, Yang B, Liu X
Journal of nanobiotechnology 2025 Dec 6;23(1):767
Journal of nanobiotechnology 2025 Dec 6;23(1):767
Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis.
Yu K, Liu M, Zhang T, Guo C, Du L, Li M, Wang Q, Han N, Chi Y, Li Y
Diabetology & metabolic syndrome 2025 Dec 2;18(1):7
Diabetology & metabolic syndrome 2025 Dec 2;18(1):7
Sirtuin 1-mediated recruitment of non-structural protein 1 to glucocorticoid receptor induces glucocorticoid insensitivity post RSV infection.
Che S, Long X, Mo S, Jiang Z, Xie X, Liu E, Xie J
International journal of biological macromolecules 2025 Aug;320(Pt 1):145811
International journal of biological macromolecules 2025 Aug;320(Pt 1):145811
Hesperidin mitigates copper nanoparticle exposure-induced mitochondrial unfolded protein response through the SIRT3-FOXO3A signaling pathway.
Wu Y, Wang S, Huang H, Yu J, Liang J, Huang H, Guo J, Tang Z, Liao J
International journal of biological macromolecules 2025 Aug;320(Pt 1):145750
International journal of biological macromolecules 2025 Aug;320(Pt 1):145750
NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway.
Zhao X, He M, He L, Han R, Liu Y
Scientific reports 2025 Aug 7;15(1):28975
Scientific reports 2025 Aug 7;15(1):28975
MRPL12 K163 acetylation inhibits ccRCC via driving mitochondrial metabolic reprogramming.
Ji X, Xue F, Wang Y, Gao D, Sun J, Dong T, Mu Q, Xu Q, Sun S, Liu Y, Wan Q
Cell death & disease 2025 Aug 26;16(1):646
Cell death & disease 2025 Aug 26;16(1):646
SIRT3 Acetylation Regulates Mitophagy to Alleviate Deoxynivalenol-Induced Apoptosis in Porcine Alveolar Macrophages Cells.
Fan P, Deng H, Wang Y, Ren Z, Deng J
International journal of molecular sciences 2025 Aug 25;26(17)
International journal of molecular sciences 2025 Aug 25;26(17)
The protective effect of kaempferol on high glucose-stimulated renal tubular epithelial cells.
Jiao XC, Li Y, Wu D, Zhang XG, Hou F
BMC nephrology 2025 Aug 20;26(1):477
BMC nephrology 2025 Aug 20;26(1):477
Curcumin preserves bone health compromised by diabetes by inhibiting osteoporosis through regulation of the SIRT3/FoxO3a signalling pathway.
Mohammad OH, Yang S, Ji W, Ma H, Tao R
Scientific reports 2025 Aug 12;15(1):29566
Scientific reports 2025 Aug 12;15(1):29566
Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein.
Hu F, Tong S, Xu H
The Journal of membrane biology 2025 Apr;258(2):123-133
The Journal of membrane biology 2025 Apr;258(2):123-133
Semaglutide protects against diabetes-associated cardiac inflammation via Sirt3-dependent RKIP pathway.
Lin K, Wang A, Zhai C, Zhao Y, Hu H, Huang D, Zhai Q, Yan Y, Ge J
British journal of pharmacology 2025 Apr;182(7):1561-1581
British journal of pharmacology 2025 Apr;182(7):1561-1581
Xin-Ji-Er-Kang balances mitochondrial fusion and fission to protect cardiomyocytes in mice with heart failure by regulating the ERα/SIRT3 pathway.
Cai WW, Qin YY, Ge F, Zhou Q, Huang L, Yang PB, Xia J, Li KK, Hou YF, Wu JM, Wang DY, You Y, Lu WJ, Gao S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156420
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156420
Surfactant protein D alleviates chondrocytes senescence by upregulating SIRT3/SOD2 pathway in osteoarthritis.
Jiang H, Zhang Y, Ji P, Ming J, Li Y, Zhou Y
Molecular medicine (Cambridge, Mass.) 2025 Apr 30;31(1):161
Molecular medicine (Cambridge, Mass.) 2025 Apr 30;31(1):161
Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway.
Sun M, Wang F, Li H, Li M, Wang Y, Wang C, Zhang Y, Zhang D, Li J, Yao S
Journal of inflammation research 2024;17:1349-1364
Journal of inflammation research 2024;17:1349-1364
Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway.
Yao B, Ma J, Ran Q, Chen H, He X
Frontiers in pharmacology 2024;15:1483518
Frontiers in pharmacology 2024;15:1483518
Integrated analysis reveals crosstalk between pyroptosis and immune regulation in renal fibrosis.
Bai F, Han L, Yang J, Liu Y, Li X, Wang Y, Jiang R, Zeng Z, Gao Y, Zhang H
Frontiers in immunology 2024;15:1247382
Frontiers in immunology 2024;15:1247382
Capsaicin mitigates ventilator-induced lung injury by suppressing ferroptosis and maintaining mitochondrial redox homeostasis through SIRT3-dependent mechanisms.
Lin J, Ou H, Luo B, Ling M, Lin F, Cen L, Hu Z, Ye L, Pan L
Molecular medicine (Cambridge, Mass.) 2024 Sep 12;30(1):148
Molecular medicine (Cambridge, Mass.) 2024 Sep 12;30(1):148
Deacetylation of GLUD1 maintains the survival of lung adenocarcinoma cells under glucose starvation by inhibiting autophagic cell death.
Hu Q, Sun L, Cheng Z, Wang L, Wan X, Xu J, Cheng J, Wang Z, Yuan Y, Wang K, Han T
Cell insight 2024 Oct;3(5):100186
Cell insight 2024 Oct;3(5):100186
Dapagliflozin attenuates AKI to CKD transition in diabetes by activating SIRT3/PGC1-α signaling and alleviating aberrant metabolic reprogramming.
Li H, Xia Y, Zha H, Zhang Y, Shi L, Wang J, Huang H, Yue R, Hu B, Zhu J, Song Z
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167433
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167433
Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis.
Du R, Gao Y, Yan C, Ren X, Qi S, Liu G, Guo X, Song X, Wang H, Rao J, Zang Y, Zheng M, Li J, Huang H
iScience 2024 Oct 18;27(10):110911
iScience 2024 Oct 18;27(10):110911
SIRT3 Inhibits Cell Proliferation of Nonsmall Cell Lung Carcinoma by Inducing ROS Production.
Yu Z, Liao H, Wu G, Liu Y, Zhang G, Xiao L, Yang S, Liu J, Yang G
The clinical respiratory journal 2024 Nov;18(11):e70033
The clinical respiratory journal 2024 Nov;18(11):e70033
Sirt6 Mono-ADP-Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission.
Zhang W, Bai L, Xu W, Liu J, Chen Y, Lin W, Lu H, Wang B, Luo B, Peng G, Zhang K, Shen C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2406390
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2406390
Metformin improves HPRT1-targeted purine metabolism and repairs NR4A1-mediated autophagic flux by modulating FoxO1 nucleocytoplasmic shuttling to treat postmenopausal osteoporosis.
Yang K, Wang X, Zhang C, Liu D, Tao L
Cell death & disease 2024 Nov 6;15(11):795
Cell death & disease 2024 Nov 6;15(11):795
SIRT3 differentially regulates lysine benzoylation from SIRT2 in mammalian cells.
Peng P, Lu Y, Ren X, Yan C, Guo X, Liu R, Song X, Huang H
iScience 2024 Nov 15;27(11):111176
iScience 2024 Nov 15;27(11):111176
Resveratrol protects against myocardial ischemic injury in obese mice via activating SIRT3/FOXO3a signaling pathway and restoring redox homeostasis.
Zhu X, Ma E, Ge Y, Yuan M, Guo X, Peng J, Zhu W, Ren DN, Wo D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116476
Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis.
Han X, Ning Y, Dou X, Wang Y, Shan Q, Shi K, Wang Z, Ding C, Hao M, Wang K, Peng M, Kuang H, Yang Q, Sang X, Cao G
Journal of pharmaceutical analysis 2024 May;14(5):100927
Journal of pharmaceutical analysis 2024 May;14(5):100927
Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway.
Zhao L, Zhang X, Chen Z, Lai Y, Xu J, Zhou R, Ma P, Cai W, Zeng Y, Wu X, Ying H, Yu F
Food & function 2024 May 7;15(9):4954-4969
Food & function 2024 May 7;15(9):4954-4969
Phosphatidylserine Counteracts the High Stocking Density-Induced Stress Response, Redox Imbalance and Immunosuppression in Fish Megalobrama ambylsephala.
Jiang Y, Liu Z, Zhang L, Liu W, Li H, Li X
Antioxidants (Basel, Switzerland) 2024 May 25;13(6)
Antioxidants (Basel, Switzerland) 2024 May 25;13(6)
The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia-reperfusion-induced renal fibrosis.
Wu H, Wang L, Kang P, Zhou X, Li W, Xia Z
International immunopharmacology 2024 May 10;132:112002
International immunopharmacology 2024 May 10;132:112002
KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation.
Zhou J, Wang T, Zhang H, Liu J, Wei P, Xu R, Yan Q, Chen G, Li W, Gao SJ, Lu C
PLoS pathogens 2024 Mar;20(3):e1012082
PLoS pathogens 2024 Mar;20(3):e1012082
Corn Oligopeptide Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Sirtuin Signaling Pathway.
Xu Y, Su T, Mishra H, Ando R, Furutani Y, Lu J, Cai M, Suzuki H, Yu W, Qin XY
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6360-6371
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6360-6371
The Effectiveness of Four Nicotinamide Adenine Dinucleotide (NAD(+)) Precursors in Alleviating the High-Glucose-Induced Damage to Hepatocytes in Megalobrama amblycephala: Evidence in NAD(+) Homeostasis, Sirt1/3 Activation, Redox Defense, Inflammatory Response, Apoptosis, and Glucose Metabolism.
Dong Y, Wang X, Wei L, Liu Z, Chu X, Xiong W, Liu W, Li X
Antioxidants (Basel, Switzerland) 2024 Mar 22;13(4)
Antioxidants (Basel, Switzerland) 2024 Mar 22;13(4)
Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.
Yang W, Qiu C, Lv H, Zhang Z, Yao T, Huang L, Wu G, Zhang X, Chen J, He Y
Translational vision science & technology 2024 Mar 1;13(3):19
Translational vision science & technology 2024 Mar 1;13(3):19
PGC1-Alpha/Sirt3 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Hirudin by Inhibiting Fibroblast Senescence.
He B, Zeng Q, Tian Y, Luo Y, Liao M, Huang W, Wu B, Luo Z, Huang X, Liu W, Tang S
Biomedicines 2024 Jun 27;12(7)
Biomedicines 2024 Jun 27;12(7)
Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy.
Qu H, Liu X, Zhu J, He N, He Q, Zhang L, Wang Y, Gong X, Xiong X, Liu J, Wang C, Yang G, Yang Q, Luo G, Zhu Z, Zheng Y, Zheng H
iScience 2024 Jun 21;27(6):109796
iScience 2024 Jun 21;27(6):109796
The Selective SIRT3 Inhibitor 3-TYP Represses Primary Myeloma Growth by Reducing c-Myc Stability.
Zeng Y, Zhang Y, Cui Z, Mao J, Xu J, Yao R
Chemical research in toxicology 2024 Jun 17;37(6):1062-1069
Chemical research in toxicology 2024 Jun 17;37(6):1062-1069
Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity.
Zhu W, Lian N, Wang J, Zhao F, Liu B, Sheng J, Zhang C, Zhou X, Gao W, Xie C, Gu H, Zhang Y, Bian M, Jiang M, Li Y
Chinese medicine 2024 Jun 14;19(1):85
Chinese medicine 2024 Jun 14;19(1):85
Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model.
Basel A, Bhadsavle SS, Scaturro KZ, Parkey GK, Gaytan MN, Patel JJ, Thomas KN, Golding MC
Aging and disease 2024 Jul 20;16(4):2408-2425
Aging and disease 2024 Jul 20;16(4):2408-2425
Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia.
Chen LL, Li YQ, Kang ZH, Zhang X, Gu SY, Wang N, Shen XY
Molecular and cellular endocrinology 2024 Jan 1;579:112073
Molecular and cellular endocrinology 2024 Jan 1;579:112073
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice.
Zhou Y, Zhao Q, Zhang Y, Di L, Xue F, Xu W, Gao W, Guo Y, He Y, Kou J, Qin Y, Xie X, Du L, Han G, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155298
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155298
Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.
Wei Y, Wang X, Ma Z, Xiang P, Liu G, Yin B, Hou L, Shu P, Liu W, Peng X
iScience 2024 Feb 16;27(2):108706
iScience 2024 Feb 16;27(2):108706
Ruscogenin attenuates osteoarthritis by modulating oxidative stress-mediated macrophage reprogramming via directly targeting Sirt3.
Liu Y, Li W, Tang H, Yang Z, Wei M, Zhou W, Li Z, Huang W
International immunopharmacology 2024 Dec 25;143(Pt 1):113336
International immunopharmacology 2024 Dec 25;143(Pt 1):113336
Dihydrolipoyl dehydrogenase promotes white adipocytes browning by activating the RAS/ERK pathway and undergoing crotonylation modification.
Liu Y, Liang J, Liu Z, Tian X, Sun C
International journal of biological macromolecules 2024 Apr;265(Pt 1):130816
International journal of biological macromolecules 2024 Apr;265(Pt 1):130816
Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.
Zhang A, Pan Y, Wang H, Ding R, Zou T, Guo D, Shen Y, Ji P, Huang W, Wen Q, Wang Q, Hu H, Wu J, Xiang M, Ye B
Aging cell 2024 Apr;23(4):e14091
Aging cell 2024 Apr;23(4):e14091
Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3.
Zhang W, Fan Z, Wang F, Yin L, Wu J, Li D, Song S, Wang X, Tang Y, Huang C
Oxidative medicine and cellular longevity 2023;2023:9966355
Oxidative medicine and cellular longevity 2023;2023:9966355
Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway.
Xiao L, Fang Z, Wang Q, Sheng X, Qi X, Xing K, Guo Y, Ni H, Wang X, Zhang Y
Oxidative medicine and cellular longevity 2023;2023:1708251
Oxidative medicine and cellular longevity 2023;2023:1708251
Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway.
Jin X, He R, Lin Y, Liu J, Wang Y, Li Z, Liao Y, Yang S
Drug design, development and therapy 2023;17:3363-3383
Drug design, development and therapy 2023;17:3363-3383
Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway.
He H, Liu P, Li P
Drug design, development and therapy 2023;17:3205-3218
Drug design, development and therapy 2023;17:3205-3218
SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages.
Guo M, Zhuang H, Su Y, Meng Q, Liu W, Liu N, Wei M, Dai SM, Deng H
Frontiers in immunology 2023;14:1128543
Frontiers in immunology 2023;14:1128543
Metabolic reprogramming induced by DCA enhances cisplatin sensitivity through increasing mitochondrial oxidative stress in cholangiocarcinoma.
Qin H, Zheng G, Li Q, Shen L
Frontiers in pharmacology 2023;14:1128312
Frontiers in pharmacology 2023;14:1128312
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Koh YC, Lin SJ, Hsu KY, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
Wang X, Wu H, An J, Zhang G, Chen Y, Fu L, Tao L, Liang G, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
Zhan R, Meng X, Tian D, Xu J, Cui H, Yang J, Xu Y, Shi M, Xue J, Yu W, Hu G, Li K, Ge X, Zhang Q, Zhao M, Du J, Guo X, Xu W, Gao Y, Yao C, Chen F, Chen Y, Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E, Wang Y, Zheng L
Neuron 2023 Nov 15;111(22):3634-3649.e7
Neuron 2023 Nov 15;111(22):3634-3649.e7
Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity.
Kong W, Peng Y, Ji C, Liu Z, Gao S, Zhang Y, Chen J, Li X, Bao M, Zhang Y, Jiang Q, Wang F, Li Z, Bian X, Ye J
Clinical science (London, England : 1979) 2023 May 31;137(10):823-841
Clinical science (London, England : 1979) 2023 May 31;137(10):823-841
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B
Diabetes 2023 May 1;72(5):611-626
Diabetes 2023 May 1;72(5):611-626
Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis.
Zi Y, Wang X, Zi Y, Yu H, Lan Y, Fan Y, Ren C, Liao K, Chen H
Free radical biology & medicine 2023 May 1;200:73-86
Free radical biology & medicine 2023 May 1;200:73-86
Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling.
Liu LW, Xie Y, Li GQ, Zhang T, Sui YH, Zhao ZJ, Zhang YY, Yang WB, Geng XL, Xue DB, Chen H, Wang YW, Lu TQ, Shang LR, Li ZB, Li L, Sun B
British journal of pharmacology 2023 Mar;180(5):647-666
British journal of pharmacology 2023 Mar;180(5):647-666
Bioactivity-based molecular networking-guided identification of guttiferone J from Garcinia cambogia as an anti-obesity candidate.
Feng Z, Chen J, Chen C, Feng L, Wang R, Zhu J, Lou R, Liu J, Ye Y, Lin L
British journal of pharmacology 2023 Mar;180(5):589-608
British journal of pharmacology 2023 Mar;180(5):589-608
Effects of Exercise Preconditioning on Doxorubicin-Induced Liver and Kidney Toxicity in Male and Female Rats.
Boeno FP, Patel J, Montalvo RN, Lapierre-Nguyen SS, Schreiber CM, Smuder AJ
International journal of molecular sciences 2023 Jun 16;24(12)
International journal of molecular sciences 2023 Jun 16;24(12)
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Koh YC, Chok D, Chang CH, Wei CC, Wu CT, Cheng KC, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
Wei Y, Xiao G, Xu H, Sun X, Shi Y, Wang F, Kang J, Peng J, Zhou F
The FEBS journal 2023 Jul;290(14):3629-3645
The FEBS journal 2023 Jul;290(14):3629-3645
SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.
Huang P, Zhao H, Pan X, Li J, Pan W, Dai H, Wang J, Xia C, Liu F
Biochemical pharmacology 2023 Jul;213:115592
Biochemical pharmacology 2023 Jul;213:115592
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Qin Y, Shi Y, Yu Q, Yang S, Wang Y, Dai X, Li G, Cheng Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114761
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114761
Resveratrol reverses TGF-β1-mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis.
Wang J, Huang P, Pan X, Xia C, Zhang H, Zhao H, Yuan Z, Liu J, Meng C, Liu F
Phytotherapy research : PTR 2023 Jan;37(1):211-230
Phytotherapy research : PTR 2023 Jan;37(1):211-230
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
Li Y, Shen B, Lv C, Zhu X, Naren Q, Xu D, Chen H, Wu F
International immunopharmacology 2023 Jan;114:109489
International immunopharmacology 2023 Jan;114:109489
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
Lin S, Yang F, Hu M, Chen J, Chen G, Hu A, Li X, Fu D, Xing C, Xiong Z, Wu Y, Cao H
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics.
Wang R, Xu H, Tan B, Yi Q, Sun Y, Xiang H, Chen T, Liu H, Xie Q, Wang L, Tian J, Zhu J
Free radical biology & medicine 2023 Feb 1;195:270-282
Free radical biology & medicine 2023 Feb 1;195:270-282
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, Wang H, Ji Y, Xie LP, Gu AH, Sun CQ, Wang QM, Wang LS
Archives of toxicology 2023 Dec;97(12):3209-3226
Archives of toxicology 2023 Dec;97(12):3209-3226
Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated m(6)A modification of SIRT3 mRNA.
Zhang Y, Wang R, Tan H, Wu K, Hu Y, Diao H, Wang D, Tang X, Leng M, Li X, Cai Z, Luo D, Shao X, Yan M, Chen Y, Rong X, Guo J
Journal of ethnopharmacology 2023 Dec 5;317:116766
Journal of ethnopharmacology 2023 Dec 5;317:116766
Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models.
Sanz-Alcázar A, Britti E, Delaspre F, Medina-Carbonero M, Pazos-Gil M, Tamarit J, Ros J, Cabiscol E
Cellular and molecular life sciences : CMLS 2023 Dec 21;81(1):12
Cellular and molecular life sciences : CMLS 2023 Dec 21;81(1):12
SIRT3 Regulates Levels of Deacetylated SOD2 to Prevent Oxidative Stress and Mitochondrial Dysfunction During Oocyte Maturation in Pigs.
Jiao L, Hu CX, Zhang Y, Zhang YX, Cai WW, Pan WL, Sun SC, Zhang Y
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 Dec 21;29(6):2149-2160
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 Dec 21;29(6):2149-2160
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Cong L, Liu X, Bai Y, Qin Q, Zhao L, Shi Y, Bai Y, Guo Z
Biological research 2023 Dec 2;56(1):62
Biological research 2023 Dec 2;56(1):62
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Wang Y, Chen X, Baker JS, Davison GW, Xu S, Zhou Y, Bao X
European journal of nutrition 2023 Apr;62(3):1453-1466
European journal of nutrition 2023 Apr;62(3):1453-1466
Combination of Perindopril Erbumine and Huangqi-Danshen Decoction Protects Against Chronic Kidney Disease via Sirtuin3/Mitochondrial Dynamics Pathway.
Wei X, Wang Y, Weng J, Lao Y, Deng R, Lu J, Yang S, Liu X
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5812105
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5812105
Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage.
Liao X, Lv X, Zhang Y, Han Y, Li J, Zeng J, Tang D, Meng J, Yuan X, Peng Z, Tao L, Xie Y
Oxidative medicine and cellular longevity 2022;2022:2453617
Oxidative medicine and cellular longevity 2022;2022:2453617
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Wang L, Wang J
Oxidative medicine and cellular longevity 2022;2022:1755608
Oxidative medicine and cellular longevity 2022;2022:1755608
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway.
Li Q, Tan JX, He Y, Bai F, Li SW, Hou YW, Ji LS, Gao YT, Zhang X, Zhou ZH, Yu Z, Fang M, Gao YQ, Li M
International journal of biological sciences 2022;18(4):1594-1611
International journal of biological sciences 2022;18(4):1594-1611
Mitochonic Acid-5 Inhibits Reactive Oxygen Species Production and Improves Human Chondrocyte Survival by Upregulating SIRT3-Mediated, Parkin-dependent Mitophagy.
Xin R, Xu Y, Long D, Mao G, Liao H, Zhang Z, Kang Y
Frontiers in pharmacology 2022;13:911716
Frontiers in pharmacology 2022;13:911716
Atractylon inhibits the tumorigenesis of glioblastoma through SIRT3 signaling.
Sun S, Shi J, Wang X, Huang C, Huang Y, Xu J, Jiang Y, Cao L, Xie T, Wang Y, Huang Z
American journal of cancer research 2022;12(5):2310-2322
American journal of cancer research 2022;12(5):2310-2322
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Peng Y, Liao K, Tan F, Liang Y, Sun X, Cui Z, Ye B, Chen Z, Tang S, Chen J
Experimental eye research 2022 Sep;222:109158
Experimental eye research 2022 Sep;222:109158
Fraxinellone inhibits progression of glioblastoma via regulating the SIRT3 signaling pathway.
Shi J, Sun S, Xing S, Huang C, Huang Y, Wang Q, Xue X, Chen Z, Wang Y, Huang Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113416
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113416
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350
Nature communications 2022 Oct 26;13(1):6350
[Effects of Long-Term Ethanol Consumption on Learning-Memory Functions in Mice and the Mechanisms Involved].
Zhou J, Wu W, Ji LW, Li Q, Liang Y, Li T, Yang L
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2022 Nov;53(6):1049-1054
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2022 Nov;53(6):1049-1054
Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway.
Yao Y, Ren Z, Yang R, Mei Y, Dai Y, Cheng Q, Xu C, Xu X, Wang S, Kim KM, Noh JH, Zhu J, Zhao N, Liu YU, Mao G, Sima J
Cell & bioscience 2022 Nov 4;12(1):180
Cell & bioscience 2022 Nov 4;12(1):180
Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling.
Gao S, Yang Q, Liu Z, Kong W, Chen J, Li X, Peng Y, Bao M, Bian X, Zhang Y, Jiang Q, Li Z, Zhang Y, Yan F, Ye J
Clinical science (London, England : 1979) 2022 Nov 30;136(22):1711-1730
Clinical science (London, England : 1979) 2022 Nov 30;136(22):1711-1730
Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation.
Hou T, Tian Y, Cao Z, Zhang J, Feng T, Tao W, Sun H, Wen H, Lu X, Zhu Q, Li M, Lu X, Liu B, Zhao Y, Yang Y, Zhu WG
Molecular cell 2022 Nov 3;82(21):4099-4115.e9
Molecular cell 2022 Nov 3;82(21):4099-4115.e9
SIRT3-AMPK signaling pathway as a protective target in endothelial dysfunction of early sepsis.
Yu H, Liu Q, Chen G, Huang L, Luo M, Lv D, Luo S
International immunopharmacology 2022 May;106:108600
International immunopharmacology 2022 May;106:108600
Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.
Head PE, Myung S, Chen Y, Schneller JL, Wang C, Duncan N, Hoffman P, Chang D, Gebremariam A, Gucek M, Manoli I, Venditti CP
Science translational medicine 2022 May 25;14(646):eabn4772
Science translational medicine 2022 May 25;14(646):eabn4772
Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin-induced acute kidney injury.
Yu C, Li T, Li J, Cui B, Liu N, Bayliss G, Zhuang S
Journal of cellular and molecular medicine 2022 Jul;26(14):4061-4075
Journal of cellular and molecular medicine 2022 Jul;26(14):4061-4075
Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3.
Zhang Q, Ren J, Wang F, Pan M, Cui L, Li M, Qu F
Free radical biology & medicine 2022 Jul;187:1-16
Free radical biology & medicine 2022 Jul;187:1-16
The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3.
Chen DK, Shao HY, Yang L, Hu JM
Natural products and bioprospecting 2022 Jan 27;12(1):1
Natural products and bioprospecting 2022 Jan 27;12(1):1
The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells.
Fu X, Li K, Niu Y, Lin Q, Liang H, Luo X, Liu L, Li N
Microbiology spectrum 2022 Feb 23;10(1):e0231021
Microbiology spectrum 2022 Feb 23;10(1):e0231021
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Zhang S, Wu X, Wang J, Shi Y, Hu Q, Cui W, Bai H, Zhou J, Du Y, Han L, Li L, Feng D, Ge S, Qu Y
Redox biology 2022 Aug;54:102390
Redox biology 2022 Aug;54:102390
Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis.
Zhang L, Shi J, Du D, Niu N, Liu S, Yang X, Lu P, Shen X, Shi N, Yao L, Zhang R, Hu G, Lu G, Zhu Q, Zeng T, Liu T, Xia Q, Huang W, Xue J
EBioMedicine 2022 Apr;78:103959
EBioMedicine 2022 Apr;78:103959
Antimelanoma Effects of Concomitant Inhibition of SIRT1 and SIRT3 in Braf(V600E)/Pten(NULL) Mice.
Chhabra G, Singh CK, Guzmán-Pérez G, Ndiaye MA, Iczkowski KA, Ahmad N
The Journal of investigative dermatology 2022 Apr;142(4):1145-1157.e7
The Journal of investigative dermatology 2022 Apr;142(4):1145-1157.e7
Honokiol improves endothelial function in type 2 diabetic rats via alleviating oxidative stress and insulin resistance.
He A, Yu H, Hu Y, Chen H, Li X, Shen J, Zhuang R, Chen Y, Sasmita BR, Luo M, Lv D
Biochemical and biophysical research communications 2022 Apr 16;600:109-116
Biochemical and biophysical research communications 2022 Apr 16;600:109-116
The Protective Effect of 1,25(OH)(2)D(3) on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism.
Yang J, Zhang Y, Pan Y, Sun C, Liu Z, Liu N, Fu Y, Li X, Li Y, Kong J
Frontiers in cell and developmental biology 2021;9:627135
Frontiers in cell and developmental biology 2021;9:627135
Jian-Pi-Yi-Shen Formula Alleviates Chronic Kidney Disease in Two Rat Models by Modulating QPRT/NAD(+)/SIRT3/Mitochondrial Dynamics Pathway.
Liu X, Liu S, Zhang B, Luo D, Huang S, Wang F, Zheng L, Lu J, Chen J, Li S
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6625345
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6625345
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Lv D, Luo M, Cheng Z, Wang R, Yang X, Guo Y, Huang L, Li X, Huang B, Shen J, Luo S, Yan J
Oxidative medicine and cellular longevity 2021;2021:5577019
Oxidative medicine and cellular longevity 2021;2021:5577019
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Liu X, Luo D, Huang S, Liu S, Zhang B, Wang F, Lu J, Chen J, Li S
Frontiers in physiology 2021;12:723690
Frontiers in physiology 2021;12:723690
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Pan J, Cao Z, Fang C, Lei Y, Sun J, Huang X, Han D
Frontiers in pharmacology 2021;12:722530
Frontiers in pharmacology 2021;12:722530
Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects.
Liu X, Deng R, Wei X, Wang Y, Weng J, Lao Y, Lu J, Xiong G, Li S
Bioscience reports 2021 Oct 29;41(10)
Bioscience reports 2021 Oct 29;41(10)
Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.
Sivalingam K, Doke M, Khan MA, Samikkannu T
Scientific reports 2021 Oct 29;11(1):21335
Scientific reports 2021 Oct 29;11(1):21335
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
Sun XC, Wang Y, Zeng HF, Xi YM, Lin H, Han ZY, Chen KL
Cell death discovery 2021 Oct 21;7(1):304
Cell death discovery 2021 Oct 21;7(1):304
The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.
Yue XF, Shen CX, Wang JW, Dai LY, Fang Q, Long L, Zhi Y, Li XR, Wang YW, Shen GF, Liu ZJ, Shi CM, Li WB
Asian journal of andrology 2021 May-Jun;23(3):249-258
Asian journal of andrology 2021 May-Jun;23(3):249-258
CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice.
Gan L, Liu D, Liu J, Chen E, Chen C, Liu L, Hu H, Guan X, Ma W, Zhang Y, He Y, Liu B, Tang S, Jiang W, Xue J, Xin H
Signal transduction and targeted therapy 2021 Jun 11;6(1):223
Signal transduction and targeted therapy 2021 Jun 11;6(1):223
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3.
Yang X, Li X, Luo M, Li C, Huang L, Li X, Huang B, Shen J, Luo S, Yan J
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):897-907
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):897-907
Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels.
Gombos Z, Koltai E, Torma F, Bakonyi P, Kolonics A, Aczel D, Ditroi T, Nagy P, Kawamura T, Radak Z
International journal of molecular sciences 2021 Jul 15;22(14)
International journal of molecular sciences 2021 Jul 15;22(14)
Endurance Exercise-Induced Autophagy/Mitophagy Coincides with a Reinforced Anabolic State and Increased Mitochondrial Turnover in the Cortex of Young Male Mouse Brain.
Kwon I, Jang Y, Lee Y
Journal of molecular neuroscience : MN 2021 Jan;71(1):42-54
Journal of molecular neuroscience : MN 2021 Jan;71(1):42-54
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Yang W, Liu J, Hou L, Chen Q, Liu Y
Life sciences 2021 Jan 15;265:118796
Life sciences 2021 Jan 15;265:118796
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Cui W, Wu X, Shi Y, Guo W, Luo J, Liu H, Zheng L, Du Y, Wang P, Wang Q, Feng D, Ge S, Qu Y
Cell proliferation 2021 Feb;54(2):e12964
Cell proliferation 2021 Feb;54(2):e12964
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.
Chen H, Zhang DM, Zhang ZP, Li MZ, Wu HF
Genes & genomics 2021 Dec;43(12):1433-1444
Genes & genomics 2021 Dec;43(12):1433-1444
Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling.
Chen Y, Zhang H, Ji S, Jia P, Chen Y, Li Y, Wang T
Free radical biology & medicine 2021 Dec;177:1-14
Free radical biology & medicine 2021 Dec;177:1-14
Proteomic analysis of lysine acetylation reveals that metabolic enzymes and heat shock proteins may be potential targets for DSS-induced mice colitis.
Wang JM, Lin SR, Zhu YB, Yuan J, Wang YM, Zhang Q, Xie LS, Li SH, Liu SQ, Yu SG, Wu QF
International immunopharmacology 2021 Dec;101(Pt B):108336
International immunopharmacology 2021 Dec;101(Pt B):108336
Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3.
Cheng Z, Lv D, Luo M, Wang R, Guo Y, Yang X, Huang L, Li X, Li C, Shang FF, Huang B, Shen J, Luo S, Yan J
European journal of pharmacology 2021 Aug 15;905:174186
European journal of pharmacology 2021 Aug 15;905:174186
Dioscin Protects against Aβ1-42 Oligomers-Induced Neurotoxicity via the Function of SIRT3 and Autophagy.
Zhang Z, Han K, Wang C, Sun C, Jia N
Chemical & pharmaceutical bulletin 2020;68(8):717-725
Chemical & pharmaceutical bulletin 2020;68(8):717-725
Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy.
Zhu Z, Li H, Chen W, Cui Y, Huang A, Qi X
Frontiers in pharmacology 2020;11:94
Frontiers in pharmacology 2020;11:94
SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels.
Han D, Jiang L, Gu X, Huang S, Pang J, Wu Y, Yin J, Wang J
Journal of cellular physiology 2020 Nov;235(11):8839-8851
Journal of cellular physiology 2020 Nov;235(11):8839-8851
Anomalous AMPK-regulated angiotensin AT(1)R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.
Chao YM, Wu KLH, Tsai PC, Tain YL, Leu S, Lee WC, Chan JYH
Journal of biomedical science 2020 May 23;27(1):68
Journal of biomedical science 2020 May 23;27(1):68
SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity.
Feng X, Wang Y, Chen W, Xu S, Li L, Geng Y, Shen A, Gao H, Zhang L, Liu S
Aging 2020 Mar 4;12(5):4178-4192
Aging 2020 Mar 4;12(5):4178-4192
RGD-PEG-PLA Delivers MiR-133 to Infarct Lesions of Acute Myocardial Infarction Model Rats for Cardiac Protection.
Sun B, Liu S, Hao R, Dong X, Fu L, Han B
Pharmaceutics 2020 Jun 21;12(6)
Pharmaceutics 2020 Jun 21;12(6)
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Xu LX, Hao LJ, Ma JQ, Liu JK, Hasim A
Molecular and cellular biochemistry 2020 Jan;464(1-2):11-20
Molecular and cellular biochemistry 2020 Jan;464(1-2):11-20
Activated PI3K/AKT Signaling Pathway Associates with Oxidative Stress and Impaired Developmental Potential of Vitrified-Thawed Oocytes.
Li J, Yang X, Liu F, Song Y, Liu Y
Reproductive sciences (Thousand Oaks, Calif.) 2020 Jan;27(1):404-410
Reproductive sciences (Thousand Oaks, Calif.) 2020 Jan;27(1):404-410
Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice.
Téglás T, Ábrahám D, Jókai M, Kondo S, Mohammadi R, Fehér J, Szabó D, Wilhelm M, Radák Z
Biogerontology 2020 Dec;21(6):807-815
Biogerontology 2020 Dec;21(6):807-815
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Dong D, Dong Y, Fu J, Lu S, Yuan C, Xia M, Sun L
Life sciences 2020 Aug 15;255:117846
Life sciences 2020 Aug 15;255:117846
Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock.
Tong Y, Dong Y, Feng Y, Li Z, Jia Y, Zhang X, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2019;2019:4929107
Oxidative medicine and cellular longevity 2019;2019:4929107
Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells.
Fan C, Ma Q, Xu M, Qiao Y, Zhang Y, Li P, Bi Y, Tang M
International journal of molecular sciences 2019 Oct 5;20(19)
International journal of molecular sciences 2019 Oct 5;20(19)
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J
Pharmacological research 2019 Aug;146:104276
Pharmacological research 2019 Aug;146:104276
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
Sun Y, Teng Z, Sun X, Zhang L, Chen J, Wang B, Lu F, Liu N, Yu M, Peng S, Wang Y, Zhao D, Zhao Y, Ren H, Cheng Z, Dong S, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats.
Chen L, He PL, Yang J, Yang YF, Wang K, Amend B, Stenzl A, Zhang YM, Wang ZL, Xing SS, Luo X
Molecular medicine reports 2019 Apr;19(4):2960-2968
Molecular medicine reports 2019 Apr;19(4):2960-2968
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Yang Y, Cao Y, Chen L, Liu F, Qi Z, Cheng X, Wang Z
Cancer medicine 2018 Sep;7(9):4610-4618
Cancer medicine 2018 Sep;7(9):4610-4618
Modulation of mitochondrial phenotypes by endurance exercise contributes to neuroprotection against a MPTP-induced animal model of PD.
Jang Y, Kwon I, Song W, Cosio-Lima LM, Taylor S, Lee Y
Life sciences 2018 Sep 15;209:455-465
Life sciences 2018 Sep 15;209:455-465
Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration.
Song Y, Li S, Geng W, Luo R, Liu W, Tu J, Wang K, Kang L, Yin H, Wu X, Gao Y, Zhang Y, Yang C
Redox biology 2018 Oct;19:339-353
Redox biology 2018 Oct;19:339-353
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Xing SS, Li J, Chen L, Yang YF, He PL, Li J, Yang J
Mechanisms of ageing and development 2018 Oct;175:1-6
Mechanisms of ageing and development 2018 Oct;175:1-6
Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.
Xu WY, Hu QS, Qin Y, Zhang B, Liu WS, Ni QX, Xu J, Yu XJ
World journal of gastroenterology 2018 Nov 21;24(43):4893-4905
World journal of gastroenterology 2018 Nov 21;24(43):4893-4905
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
Sun Y, Tian Z, Liu N, Zhang L, Gao Z, Sun X, Yu M, Wu J, Yang F, Zhao Y, Ren H, Chen H, Zhao D, Wang Y, Dong S, Xu C, Lu F, Zhang W
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, Wei X, Zhang Y, Sun Y, Zhou Z, Su H, Zhang C, Li N, Gao C, Peng J, Yi F
Nature communications 2017 Sep 4;8(1):413
Nature communications 2017 Sep 4;8(1):413
Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia.
Zhou X, Han TL, Chen H, Baker PN, Qi H, Zhang H
Experimental cell research 2017 Oct 1;359(1):195-204
Experimental cell research 2017 Oct 1;359(1):195-204
Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity.
Yoon SP, Kim J
Anatomy & cell biology 2016 Sep;49(3):165-176
Anatomy & cell biology 2016 Sep;49(3):165-176
Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells.
Jiao X, Li Y, Zhang T, Liu M, Chi Y
Biochemical and biophysical research communications 2016 Nov 18;480(3):387-393
Biochemical and biophysical research communications 2016 Nov 18;480(3):387-393
Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.
Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM
The Journal of biological chemistry 2016 Dec 30;291(53):27239-27251
The Journal of biological chemistry 2016 Dec 30;291(53):27239-27251
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SIRT3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIRT3. This antibody recognizes human,mouse,rat antigen. The SIRT3 antibody has been validated for the following applications: ELISA, WB analysis.
