Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [4]
- Immunohistochemistry [1]
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- Product number
- ABIN2840669 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Sirtuin 3 (SIRT3) (AA 250-279), (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- AA 250-279, C-Term
- Antibody clone number
- RB01967
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots.
- Handling
- Avoid freeze-thaw cycles.
Submitted references Localization of sirtuins (SIRT1-7) in the aged mouse inner ear.
Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3.
Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity.
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
FoxO1 mediates an autofeedback loop regulating SIRT1 expression.
PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status.
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway.
Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.
Takumida M, Takumida H, Katagiri Y, Anniko M
Acta oto-laryngologica 2016;136(2):120-31
Acta oto-laryngologica 2016;136(2):120-31
Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3.
He J, Hu B, Shi X, Weidert ER, Lu P, Xu M, Huang M, Kelley EE, Xie W
Molecular and cellular biology 2013 May;33(10):2047-55
Molecular and cellular biology 2013 May;33(10):2047-55
Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity.
Parker JA, Vazquez-Manrique RP, Tourette C, Farina F, Offner N, Mukhopadhyay A, Orfila AM, Darbois A, Menet S, Tissenbaum HA, Neri C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Sep 5;32(36):12630-40
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Sep 5;32(36):12630-40
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Kamarajan P, Alhazzazi TY, Danciu T, D'silva NJ, Verdin E, Kapila YL
Cancer 2012 Dec 1;118(23):5800-10
Cancer 2012 Dec 1;118(23):5800-10
FoxO1 mediates an autofeedback loop regulating SIRT1 expression.
Xiong S, Salazar G, Patrushev N, Alexander RW
The Journal of biological chemistry 2011 Feb 18;286(7):5289-99
The Journal of biological chemistry 2011 Feb 18;286(7):5289-99
PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status.
Caton PW, Holness MJ, Bishop-Bailey D, Sugden MC
The Biochemical journal 2011 Aug 1;437(3):521-30
The Biochemical journal 2011 Aug 1;437(3):521-30
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
Alhazzazi TY, Kamarajan P, Joo N, Huang JY, Verdin E, D'Silva NJ, Kapila YL
Cancer 2011 Apr 15;117(8):1670-8
Cancer 2011 Apr 15;117(8):1670-8
Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway.
Pillai VB, Sundaresan NR, Kim G, Gupta M, Rajamohan SB, Pillai JB, Samant S, Ravindra PV, Isbatan A, Gupta MP
The Journal of biological chemistry 2010 Jan 29;285(5):3133-44
The Journal of biological chemistry 2010 Jan 29;285(5):3133-44
Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.
Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, Asano T, Kurihara Y, Kurihara H
The Journal of clinical investigation 2010 Aug;120(8):2817-28
The Journal of clinical investigation 2010 Aug;120(8):2817-28
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP
The Journal of clinical investigation 2009 Sep;119(9):2758-71
The Journal of clinical investigation 2009 Sep;119(9):2758-71
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.
Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP
Molecular and cellular biology 2008 Oct;28(20):6384-401
Molecular and cellular biology 2008 Oct;28(20):6384-401
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- Submitted by
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC