21379-1-AP

antibody from Proteintech Group

Targeting: CHRNA7

Provider product page for 21379-1-AP

Western blot

ELISA

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [17]
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Validations
Western blot [1]

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Product number: 21379-1-AP - Provider product page
Provider: Proteintech Group
Product name: CHRNA7 antibody
Antibody type: Polyclonal
Description: CHRNA7 antibody (Cat. #21379-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: FC, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CHRNA7 protein structure - 21379-1-AP shown in red.

Submitted references Sacral Nerve Stimulation Alleviates Intestinal Inflammation Through Regulating the Autophagy of Macrophages and Activating the Inflammasome Mediated by a Cholinergic Antiinflammatory Pathway in Colitis Rats.

Zhang S, Zhang C, Yan H, Yang L, Shi N, Liu C, Chen Y
Neuromodulation : journal of the International Neuromodulation Society 2024 Feb;27(2):302-311

KYNA Ameliorates Glutamate Toxicity of HAND by Enhancing Glutamate Uptake in A2 Astrocytes.

Chen J, Zou J, Huang P, Gao X, Lun J, Li Y, Gong Z, Cao H
International journal of molecular sciences 2024 Apr 12;25(8)

Nicotine plays a protective role in rats with induced viral pneumonia with polyinosinic-polycytidylic acid through α7nAChR.

Liu W, Zhu Y, Yan H, Ren L, Chen J
Heliyon 2023 Nov;9(11):e21667

CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease.

Guo L, Chen Q, Gao Y, Jiang H, Zhou F, Zhang F, Xu M
Biochemical pharmacology 2023 Nov;217:115845

Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.

Lun J, Li Y, Gao X, Gong Z, Chen X, Zou J, Zhou C, Huang Y, Zhou B, Huang P, Cao H
Journal of neuroinflammation 2023 Mar 30;20(1):87

Impaired autophagy flux by lncRNA NEAT1 is critical for inflammation factors production in human periodontal ligament stem cells with nicotine treatment.

Zhang T, Yang K, Chen Y, Jiang Y, Zhou Z, Liu J, Du Y, Wang L, Han X, Wu X, Wang X
Journal of periodontal research 2023 Feb;58(1):70-82

CHRNA5 Is Overexpressed in Patients with Psoriasis and Promotes Psoriasis-Like Inflammation in Mouse Models.

Wang J, Li X, Zhang P, Yang T, Liu N, Qin L, Ma G, Li X, Fan H, Huang S, Dang N
The Journal of investigative dermatology 2022 Nov;142(11):2978-2987.e6

α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function.

Ye Z, Zhu Y, Tang N, Zhao X, Jiang J, Ma J, Zhang H
Molecular medicine (Cambridge, Mass.) 2022 Jun 3;28(1):59

The Spinal α7-Nicotinic Acetylcholine Receptor Contributes to the Maintenance of Cancer-Induced Bone Pain.

Yang T, Zhou Y, Zhang W, Zhang L, Chen S, Chen C, Gao F, Yang H, Manyande A, Wang J, Tian Y, Tian X
Journal of pain research 2021;14:441-452

Activation of α7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson's Disease Rats.

Zhou L, Zheng LF, Zhang XL, Wang ZY, Yao YS, Xiu XL, Liu CZ, Zhang Y, Feng XY, Zhu JX
Frontiers in pharmacology 2021;12:793374

Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.

Xu ZQ, Zhang JJ, Kong N, Zhang GY, Ke P, Han T, Su DF, Liu C
Frontiers in pharmacology 2021;12:676589

Differential Expression of Nicotine Acetylcholine Receptors Associates with Human Breast Cancer and Mediates Antitumor Activity of αO-Conotoxin GeXIVA.

Sun Z, Zhangsun M, Dong S, Liu Y, Qian J, Zhangsun D, Luo S
Marine drugs 2020 Jan 17;18(1)

Alpha7 nAChR Expression Is Correlated with Arthritis Development and Inhibited by Sinomenine in Adjuvant-Induced Arthritic Rats.

Peng C, Shi QP, Liu JY, Lv YJ, Li J, Yi L, Bai SS, Liu L, Wang PX, Zhou H, Huang KE, Dong Y
Evidence-based complementary and alternative medicine : eCAM 2019;2019:3759304

Identification of nicotinic acetylcholine receptor subunits in different lung cancer cell lines and the inhibitory effect of alpha-conotoxin TxID on lung cancer cell growth.

Qian J, Liu YQ, Sun ZH, Zhangsun DT, Luo SL
European journal of pharmacology 2019 Dec 15;865:172674

Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets.

Liu Y, Qian J, Sun Z, Zhangsun D, Luo S
Marine drugs 2019 Apr 28;17(5)

Activation of α7 nicotinic acetylcholine receptor alleviates Aβ(1-42)-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways.

Chang KW, Zong HF, Ma KG, Zhai WY, Yang WN, Hu XD, Xu JH, Chen XL, Ji SF, Qian YH
Neurochemistry international 2018 Nov;120:238-250

Gx-50 Inhibits Neuroinflammation via α7 nAChR Activation of the JAK2/STAT3 and PI3K/AKT Pathways.

Shi S, Liang D, Bao M, Xie Y, Xu W, Wang L, Wang Z, Qiao Z
Journal of Alzheimer's disease : JAD 2016;50(3):859-71

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CHRNA7 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CHRNA7. This antibody recognizes human, mouse, rat antigen. The CHRNA7 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 21379-1-AP.pdf

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