692302

antibody from BioLegend
Targeting: MAFB KRML
Provider product page for 692302

Antibody data

Product number
692302 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#692302, RRID:AB_2632763
Product name
Purified anti-MAFB
Antibody type
Monoclonal
Description
MAFB belongs to the Maf transcription factor family, the members of which contain basic leucine zipper (bZIP) domains that bind to DNA. These bZIP domains are located within the Maf recognition element (MARE) and regulate the transcription by binding to acidic domains within the target genes. MAFB plays roles in differentiation processes, including the differentiation of macrophage, pancreatic alpha and beta cells, podocytes in the renal glomerulus, and rhombomeres in the embryonic brain. MAFB is also central to embryonic thymus development, parathyroid gland development, the creation of hair cuticles, and urethral masculinization. In the hematopoietic system, MAFB is important for myeloid lineage commitment of hematopoietic stem cells. MAFB was recently reported to have features of oncogene. It was viewed as a sensitive and specific marker for poor prognosis in multiple myeloma patients. Silencing of MAFB inhibited migration and invasion of nasopharyngeal carcinoma cells. In liver cancer, MAFB promotes cancer cell proliferation by transcriptionally targeting Cyclin D1.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
O91E9
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
MAFB protein structure - 692302 shown in red.