22337-1-AP

antibody from Proteintech Group

Targeting: TCF4 bHLHb19, E2-2, ITF2, SEF2-1B

Provider product page for 22337-1-AP

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Antibody Data
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References [87]
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Western blot [1]
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Product number: 22337-1-AP - Provider product page
Provider: Proteintech Group
Product name: TCF4 antibody
Antibody type: Polyclonal
Description: KD/KO validated TCF4 antibody (Cat. #22337-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TCF4 protein structure - 22337-1-AP shown in red.

Submitted references The Impact of Targeting TRAF2 and NCK-Interacting Protein Kinase on Antitumor Effect and Tumor Immune Environment in c-MYC-High SCLC.

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Tcf4 Controls Neuronal Migration of the Cerebral Cortex through Regulation of Bmp7.

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Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons.

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Cell reports 2016 Apr 12;15(2):386-97

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse lung tissue were subjected to SDS PAGE followed by western blot with 22337-1-AP( TCF4 Antibody) at dilution of 1:600
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TCF4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TCF4. This antibody recognizes human, mouse antigen. The TCF4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 22337-1-AP.pdf

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