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- References [21]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11685-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11685-1-AP, RRID:AB_2252364
- Product name
- PLEK2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PLEK2 antibody (Cat. #11685-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references [Integrative Analysis of Multi-source Public Databases to Screen Core Genes
for Constructing A Prognostic Risk Model in Lung Adenocarcinoma].
PLEK2 promotes migration and invasion in pancreatic ductal adenocarcinoma by MMP1 through IL-17 pathway.
PLEK2: a potential biomarker for metastasis and prognostic evaluation in uveal melanoma.
PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25.
Pleckstrin-2 Mediates the Activation of AKT in Prostate Cancer and Is Repressed by Androgen Receptor.
Unveiling the role of Pleckstrin-2 in tumor progression and immune modulation: insights from a comprehensive pan-cancer analysis with focus on lung cancer.
PLEK2 mediates metastasis and invasion via α5-nAChR activation in nicotine-induced lung adenocarcinoma.
Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer.
Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.
Fucoxanthin Inhibits Development of Sigmoid Colorectal Cancer in a PDX Model With Alterations of Growth, Adhesion, and Cell Cycle Signals.
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.
Pleckstrin-2 as a Prognostic Factor and Mediator of Gastric Cancer Progression.
TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2.
Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.
PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway.
microRNA-873 inhibits self-renewal and proliferation of pancreatic cancer stem cells through pleckstrin-2-dependent PI3K/AKT pathway.
PLEK2 mediates metastasis and vascular invasion via the ubiquitin-dependent degradation of SHIP2 in non-small cell lung cancer.
PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.
Human trophoblast epithelial-mesenchymal transition in abnormally invasive placenta.
Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.
Wang C, Zhang L, Zhang Y, Wang Y, Wang M
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2025 Oct 20;28(10):751-760
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2025 Oct 20;28(10):751-760
PLEK2 promotes migration and invasion in pancreatic ductal adenocarcinoma by MMP1 through IL-17 pathway.
Cheng K, Chen Q, Chen Z, Cai Y, Cai H, Wu S, Gao P, Cai Y, Wu Z, Zhou J, Peng B, Wang X
Molecular and cellular biochemistry 2025 Apr;480(4):2401-2412
Molecular and cellular biochemistry 2025 Apr;480(4):2401-2412
PLEK2: a potential biomarker for metastasis and prognostic evaluation in uveal melanoma.
Liu Y, Wang H, Zhang Q, Gao X, Ji Y, Zhu Y, Zhang J, Luo W
Frontiers in medicine 2024;11:1507576
Frontiers in medicine 2024;11:1507576
PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25.
Zhang W, Yu L, Xu C, Tang T, Cao J, Chen L, Pang X, Ren W
Cell biology international 2024 Sep;48(9):1285-1300
Cell biology international 2024 Sep;48(9):1285-1300
Pleckstrin-2 Mediates the Activation of AKT in Prostate Cancer and Is Repressed by Androgen Receptor.
Han X, Zhang A, Wang P, Bi H, Ren K, Li E, Yang X, Aydemir I, Tao K, Lin J, Abdulkadir SA, Yang J, Ji P
The American journal of pathology 2024 Oct;194(10):1986-1996
The American journal of pathology 2024 Oct;194(10):1986-1996
Unveiling the role of Pleckstrin-2 in tumor progression and immune modulation: insights from a comprehensive pan-cancer analysis with focus on lung cancer.
Yin E, Liu C, Yao Y, Luo Y, Yang Y, Tang X, Zheng S, Tian L, He J
Molecular biomedicine 2024 Nov 15;5(1):59
Molecular biomedicine 2024 Nov 15;5(1):59
PLEK2 mediates metastasis and invasion via α5-nAChR activation in nicotine-induced lung adenocarcinoma.
Li Q, Li J, Wang J, Wang J, Lu T, Jia Y, Sun H, Ma X
Molecular carcinogenesis 2024 Feb;63(2):253-265
Molecular carcinogenesis 2024 Feb;63(2):253-265
Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer.
Mao D, Zhou Z, Chen H, Liu X, Li D, Chen X, He Y, Liu M, Zhang C
Cancer letters 2023 Sep 28;572:216351
Cancer letters 2023 Sep 28;572:216351
Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.
Han X, Mei Y, Mishra RK, Bi H, Jain AD, Schiltz GE, Zhao B, Sukhanova M, Wang P, Grigorescu AA, Weber PC, Piwinski JJ, Prado MA, Paulo JA, Stephens L, Anderson KE, Abrams CS, Yang J, Ji P
The Journal of clinical investigation 2023 Mar 15;133(6)
The Journal of clinical investigation 2023 Mar 15;133(6)
Fucoxanthin Inhibits Development of Sigmoid Colorectal Cancer in a PDX Model With Alterations of Growth, Adhesion, and Cell Cycle Signals.
Terasaki M, Tsuruoka K, Tanaka T, Maeda H, Shibata M, Miyashita K, Kanemitsu Y, Sekine S, Takahashi M, Yagishita S, Hamada A
Cancer genomics & proteomics 2023 Dec;20(6suppl):686-705
Cancer genomics & proteomics 2023 Dec;20(6suppl):686-705
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.
Zhao X, Shu D, Sun W, Si S, Ran W, Guo B, Cui L
Cancer communications (London, England) 2022 Oct;42(10):987-1007
Cancer communications (London, England) 2022 Oct;42(10):987-1007
Pleckstrin-2 as a Prognostic Factor and Mediator of Gastric Cancer Progression.
Wang J, He Z, Sun B, Huang W, Xiang J, Chen Z, Li Z, Gu X
Gastroenterology research and practice 2021;2021:5527387
Gastroenterology research and practice 2021;2021:5527387
TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2.
Wang F, Zhang C, Cheng H, Liu C, Lu Z, Zheng S, Wang S, Sun N, He J
Cell death & disease 2021 Oct 2;12(10):901
Cell death & disease 2021 Oct 2;12(10):901
Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.
Feola M, Zamperone A, Moskop D, Chen H, Casu C, Lama D, Di Martino J, Djedaini M, Papa L, Martinez MR, Choesang T, Bravo-Cordero JJ, MacKay M, Zumbo P, Brinkman N, Abrams CS, Rivella S, Hattangadi S, Mason CE, Hoffman R, Ji P, Follenzi A, Ginzburg YZ
Communications biology 2021 May 3;4(1):517
Communications biology 2021 May 3;4(1):517
PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway.
Liu Y, Yang S, Wang F, Zhou Z, Xu W, Xie J, Qiao L, Gu Y
Oncology letters 2021 Jul;22(1):534
Oncology letters 2021 Jul;22(1):534
microRNA-873 inhibits self-renewal and proliferation of pancreatic cancer stem cells through pleckstrin-2-dependent PI3K/AKT pathway.
Yang XL, Ma YS, Liu YS, Jiang XH, Ding H, Shi Y, Jia CY, Lu GX, Zhang DD, Wang HM, Wang PY, Lv ZW, Yu F, Liu JB, Fu D
Cellular signalling 2021 Aug;84:110025
Cellular signalling 2021 Aug;84:110025
PLEK2 mediates metastasis and vascular invasion via the ubiquitin-dependent degradation of SHIP2 in non-small cell lung cancer.
Wu DM, Deng SH, Zhou J, Han R, Liu T, Zhang T, Li J, Chen JP, Xu Y
International journal of cancer 2020 May 1;146(9):2563-2575
International journal of cancer 2020 May 1;146(9):2563-2575
PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.
Shen H, He M, Lin R, Zhan M, Xu S, Huang X, Xu C, Chen W, Yao Y, Mohan M, Wang J
Journal of experimental & clinical cancer research : CR 2019 Jun 10;38(1):247
Journal of experimental & clinical cancer research : CR 2019 Jun 10;38(1):247
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.
Zhao B, Mei Y, Cao L, Zhang J, Sumagin R, Yang J, Gao J, Schipma MJ, Wang Y, Thorsheim C, Zhao L, Stalker T, Stein B, Wen QJ, Crispino JD, Abrams CS, Ji P
The Journal of clinical investigation 2018 Jan 2;128(1):125-140
The Journal of clinical investigation 2018 Jan 2;128(1):125-140
Human trophoblast epithelial-mesenchymal transition in abnormally invasive placenta.
DaSilva-Arnold SC, Zamudio S, Al-Khan A, Alvarez-Perez J, Mannion C, Koenig C, Luke D, Perez AM, Petroff M, Alvarez M, Illsley NP
Biology of reproduction 2018 Aug 1;99(2):409-421
Biology of reproduction 2018 Aug 1;99(2):409-421
Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.
Zhao B, Keerthivasan G, Mei Y, Yang J, McElherne J, Wong P, Doench JG, Feng G, Root DE, Ji P
Haematologica 2014 Jul;99(7):1157-67
Haematologica 2014 Jul;99(7):1157-67
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 11685-1-AP(PLEK2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PLEK2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PLEK2. This antibody recognizes human, mouse, rat antigen. The PLEK2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
