Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS2331 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS2331, RRID:AB_1662201
- Product name
- DBC 1 (Q455) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 420-476 of Human DBC-1.
- Description
- DBC1 (deleted in bladder cancer 1), also known as DBCCR1 or FAM5A, is a novel 761 amino acid cytoplasmic protein that functions as an essential regulator of tumorigenesis and mediates expression of components of the plasminogen pathway. Evolutionarily conserved and highly expressed in brain, DBC1 is found at weak levels in small intestine, lung, kidney, testis, prostate, thymus, heart and kidney. DBC1 contains one MACPF domain, belongs to the FAM5 family and inhibits cell proliferation at the G1S transition via negative regulation. DBC1 contains a 5' CpG island that, when hypermethylated, leads to silencing in 50 percent of bladder cancer cell lines.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of Siah-1/2 (Q210) pAb in extracts from A549 cells.