AF1092

antibody from Novus Biologicals

Targeting: SIGIRR IL-1R8, TIR8

Western blot (Data presented on provider website)

Antibody Data

Product number

AF1092

Provider

Novus Biologicals

Product name

Goat Polyclonal SIGIRR Antibody

Antibody type

Polyclonal

Description

Antigen Affinity-purified. Detects mouse SIGIRR in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) SIGIRR is observed.

Reactivity

Mouse

Host

Goat

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

References

Submitted references

Vasoactive intestinal peptide downregulates proinflammatory TLRs while upregulating anti-inflammatory TLRs in the infected cornea.

Jiang X, McClellan SA, Barrett RP, Zhang Y, Hazlett LD
Journal of immunology (Baltimore, Md. : 1950) 2012 Jul 1;189(1):269-78

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The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.

Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Sass Bak-Jensen K, McGeachy MJ, Do JS, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, Cua DJ, Li X
Immunity 2010 Jan 29;32(1):54-66

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The Toll-IL-1R member Tir8/SIGIRR negatively regulates adaptive immunity against kidney grafts.

Noris M, Cassis P, Azzollini N, Cavinato R, Cugini D, Casiraghi F, Aiello S, Solini S, Cassis L, Mister M, Todeschini M, Abbate M, Benigni A, Trionfini P, Tomasoni S, Mele C, Garlanda C, Polentarutti N, Mantovani A, Remuzzi G
Journal of immunology (Baltimore, Md. : 1950) 2009 Oct 1;183(7):4249-60