AF990

antibody from Novus Biologicals

Targeting: SIGIRR IL-1R8, TIR8

Western blot (Data presented on provider website)

Antibody Data

Product number

AF990

Provider

Novus Biologicals

Product name

Goat Polyclonal SIGIRR Antibody

Antibody type

Polyclonal

Description

Antigen Affinity-purified. Detects human SIGIRR in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant human (rh) IL-1 R9, rhIL-1 R1, rhIL-1 R2, rhIL-1 R3, rhIL-1 R6, rhIL-1 R7, rhIL-1 R8, and rhIL-18 R is observed.

Reactivity

Human

Host

Goat

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

References

Submitted references

Staphylococcus aureus intra-mammary infection affects the expression pattern of IL-R8 in goat.

Filipe J, Bronzo V, Curone G, Castiglioni B, Vigo D, Smith B, Herrera V, Roccabianca P, Moroni P, Riva F
Comparative immunology, microbiology and infectious diseases 2019 Oct;66:101339

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Lipopolysaccharide decreases single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR) expression by suppressing specificity protein 1 (Sp1) via the Toll-like receptor 4 (TLR4)-p38 pathway in monocytes and neutrophils.

Ueno-Shuto K, Kato K, Tasaki Y, Sato M, Sato K, Uchida Y, Sakai H, Ono T, Suico MA, Mitsutake K, Tokutomi N, Kai H, Shuto T
The Journal of biological chemistry 2014 Jun 27;289(26):18097-109

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The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells.

Khan MA, Steiner TS, Sham HP, Bergstrom KS, Huang JT, Assi K, Salh B, Tai IT, Li X, Vallance BA
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 1;184(5):2305-13