Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations [0]
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- Product number
- AF990 - Provider product page
- Provider
- R&D Systems
- Product name
- Human SIGIRR Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human SIGIRR in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant human (rh) IL-1 R9, rhIL-1 R1, rhIL-1 R2, rhIL-1 R3, rhIL-1 R6, rhIL-1 R7, rhIL-1 R8, and rhIL-18 R is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q6IA17
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Lipopolysaccharide decreases single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR) expression by suppressing specificity protein 1 (Sp1) via the Toll-like receptor 4 (TLR4)-p38 pathway in monocytes and neutrophils.
The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells.
Ueno-Shuto K, Kato K, Tasaki Y, Sato M, Sato K, Uchida Y, Sakai H, Ono T, Suico MA, Mitsutake K, Tokutomi N, Kai H, Shuto T
The Journal of biological chemistry 2014 Jun 27;289(26):18097-109
The Journal of biological chemistry 2014 Jun 27;289(26):18097-109
The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells.
Khan MA, Steiner TS, Sham HP, Bergstrom KS, Huang JT, Assi K, Salh B, Tai IT, Li X, Vallance BA
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 1;184(5):2305-13
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 1;184(5):2305-13
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