15497-1-AP
antibody from Proteintech Group
Targeting: TNFRSF10B
CD262, DR5, KILLER, TRAIL-R2, TRAILR2, TRICK2A, TRICKB
Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 15497-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15497-1-AP, RRID:AB_2240702
- Product name
- DR5-Specific antibody
- Antibody type
- Polyclonal
- Description
- DR5-Specific antibody (Cat. #15497-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway.
Sanggenon C Suppresses Tumorigenesis of Gastric Cancer by Blocking ERK-Drp1-Mediated Mitochondrial Fission.
Andrographolide elevates tumor necrosis factor-related apoptosis-inducing ligand lethality through reactive oxygen species accumulation and gasdermin E cleavage in breast cancer cells.
A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism.
TRAIL produced by SAM-1-activated CD4(+) and CD8(+) subgroup T cells induces apoptosis in human tumor cells through upregulation of death receptors.
YM155 sensitizes HeLa cells to TRAIL-mediated apoptosis via cFLIP and survivin downregulation.
Luteolin enhances TRAIL sensitivity in non-small cell lung cancer cells through increasing DR5 expression and Drp1-mediated mitochondrial fission.
CRISPR-mediated upregulation of DR5 and downregulation of cFLIP synergistically sensitize HeLa cells to TRAIL-mediated apoptosis.
Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis.
Discovery and Characterization of 4-Hydroxy-2-pyridone Derivative Sambutoxin as a Potent and Promising Anticancer Drug Candidate: Activity and Molecular Mechanism.
A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure.
Pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer.
Li S, Liu H, Liu W, Shi N, Zhao M, Wanggou S, Luo W, Wang L, Zhu B, Zuo X, Xie W, Zhao C, Zhou Y, Luo L, Gao X, Jiang X, Ren C
International journal of biological sciences 2023;19(3):916-935
International journal of biological sciences 2023;19(3):916-935
Sanggenon C Suppresses Tumorigenesis of Gastric Cancer by Blocking ERK-Drp1-Mediated Mitochondrial Fission.
Chen XJ, Cui QX, Wang GL, Li XL, Zhou XL, Zhao HJ, Zhang MQ, Li MJ, He XJ, Zheng QS, Wang YL, Li D, Hong P
Journal of natural products 2022 Oct 28;85(10):2351-2362
Journal of natural products 2022 Oct 28;85(10):2351-2362
Andrographolide elevates tumor necrosis factor-related apoptosis-inducing ligand lethality through reactive oxygen species accumulation and gasdermin E cleavage in breast cancer cells.
Wang Y, Huang D, Song T, Qi X, Li M, Zhang H, Liu Y, Yang M
Medical oncology (Northwood, London, England) 2022 Nov 9;40(1):11
Medical oncology (Northwood, London, England) 2022 Nov 9;40(1):11
A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism.
Hussain M, Lu Y, Tariq M, Jiang H, Shu Y, Luo S, Zhu Q, Zhang J, Liu J
iScience 2022 Jul 15;25(7):104591
iScience 2022 Jul 15;25(7):104591
TRAIL produced by SAM-1-activated CD4(+) and CD8(+) subgroup T cells induces apoptosis in human tumor cells through upregulation of death receptors.
Zhang G, Xu M, Zhang X, Ma L, Zhang H
Toxicology and applied pharmacology 2021 Sep 15;427:115656
Toxicology and applied pharmacology 2021 Sep 15;427:115656
YM155 sensitizes HeLa cells to TRAIL-mediated apoptosis via cFLIP and survivin downregulation.
Chandrasekaran AP, Poondla N, Ko NR, Oh SJ, Ramakrishna S
Oncology letters 2020 Oct;20(4):72
Oncology letters 2020 Oct;20(4):72
Luteolin enhances TRAIL sensitivity in non-small cell lung cancer cells through increasing DR5 expression and Drp1-mediated mitochondrial fission.
Wu B, Xiong J, Zhou Y, Wu Y, Song Y, Wang N, Chen L, Zhang J
Archives of biochemistry and biophysics 2020 Oct 15;692:108539
Archives of biochemistry and biophysics 2020 Oct 15;692:108539
CRISPR-mediated upregulation of DR5 and downregulation of cFLIP synergistically sensitize HeLa cells to TRAIL-mediated apoptosis.
Poondla N, Chandrasekaran AP, Heese K, Kim KS, Ramakrishna S
Biochemical and biophysical research communications 2019 Apr 23;512(1):60-65
Biochemical and biophysical research communications 2019 Apr 23;512(1):60-65
Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis.
Hu J, Wang H, Gu J, Liu X, Zhou X
Acta biochimica et biophysica Sinica 2018 Oct 1;50(10):1018-1027
Acta biochimica et biophysica Sinica 2018 Oct 1;50(10):1018-1027
Discovery and Characterization of 4-Hydroxy-2-pyridone Derivative Sambutoxin as a Potent and Promising Anticancer Drug Candidate: Activity and Molecular Mechanism.
Li LN, Wang L, Cheng YN, Cao ZQ, Zhang XK, Guo XL
Molecular pharmaceutics 2018 Nov 5;15(11):4898-4911
Molecular pharmaceutics 2018 Nov 5;15(11):4898-4911
A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure.
Yao Y, Lu Q, Hu Z, Yu Y, Chen Q, Wang QK
Nature communications 2017 Jul 25;8(1):133
Nature communications 2017 Jul 25;8(1):133
Pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer.
Yang J, Li G, Zhang K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1078-1087
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1078-1087
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DR5-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human DR5-Specific. This antibody recognizes human antigen. The DR5-Specific antibody has been validated for the following applications: ELISA, WB analysis.