RA0750

antibody from Oursmab

Targeting: TNFRSF10B CD262, DR5, KILLER, TRAIL-R2, TRAILR2, TRICK2A, TRICKB

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0750

Provider

Oursmab

Product name

Conatumumab (Biosimilar Reference Antibody) (TNFRSF10B)

Antibody type

Monoclonal

Description

Conatumumab (also known as AMG 655) is an investigational fully human monoclonal antibody that was developed as a pro-apoptotic agent for the treatment of cancer. It functions as an agonist antibody, designed to activate a specific death receptor pathway that triggers programmed cell death in tumor cells. Clinical trials evaluated its efficacy, both as a monotherapy and in combination with chemotherapy or other targeted agents, in a range of solid tumors, including colorectal cancer, non-small cell lung cancer (NSCLC), pancreatic cancer, and soft tissue sarcoma. Despite initial promise, its development was ultimately discontinued after pivotal phase III trials failed to meet their primary survival endpoints.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.