Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 14466-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14466-1-AP, RRID:AB_2231579
- Product name
- FECH antibody
- Antibody type
- Polyclonal
- Description
- FECH antibody (Cat. #14466-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TFPI from erythroblasts drives heme production in central macrophages promoting erythropoiesis in polycythemia.
Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
Autoregulatory control of mitochondrial glutathione homeostasis.
Cell senescence-associated porphyrin metabolism affects the efficacy of aminolevulinic acid-photodynamic diagnosis in bladder cancer.
A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson's disease.
Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC.
Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas.
Disruption of cellular iron homeostasis by IREB2 missense variants causes severe neurodevelopmental delay, dystonia and seizures.
NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins.
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells.
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Involvement of protoporphyrin IX accumulation in the pathogenesis of isoniazid/rifampicin-induced liver injury: the prevention of curcumin.
A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.
Heme levels are increased in human failing hearts.
MicroRNA-210 decreases heme levels by targeting ferrochelatase in cardiomyocytes.
Ma JK, Su LD, Feng LL, Li JL, Pan L, Danzeng Q, Li Y, Shang T, Zhan XL, Chen SY, Ying S, Hu JR, Chen XQ, Zhang Q, Liang T, Lu XJ
Nature communications 2024 May 10;15(1):3976
Nature communications 2024 May 10;15(1):3976
Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK
The Journal of biological chemistry 2023 Sep;299(9):105075
The Journal of biological chemistry 2023 Sep;299(9):105075
Autoregulatory control of mitochondrial glutathione homeostasis.
Liu Y, Liu S, Tomar A, Yen FS, Unlu G, Ropek N, Weber RA, Wang Y, Khan A, Gad M, Peng J, Terzi E, Alwaseem H, Pagano AE, Heissel S, Molina H, Allwein B, Kenny TC, Possemato RL, Zhao L, Hite RK, Vinogradova EV, Mansy SS, Birsoy K
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
Cell senescence-associated porphyrin metabolism affects the efficacy of aminolevulinic acid-photodynamic diagnosis in bladder cancer.
Lai HW, Yamamoto S, Fukuhara H, Ogura SI, Inoue K
Photodiagnosis and photodynamic therapy 2023 Jun;42:103581
Photodiagnosis and photodynamic therapy 2023 Jun;42:103581
A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson's disease.
Bharat V, Durairaj AS, Vanhauwaert R, Li L, Muir CM, Chandra S, Kwak CS, Le Guen Y, Nandakishore P, Hsieh CH, Rensi SE, Altman RB, Greicius MD, Feng L, Wang X
Cell reports 2023 Dec 26;42(12):113544
Cell reports 2023 Dec 26;42(12):113544
Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC.
Xue W, Jian W, Meng Y, Wang T, Cai L, Yu Y, Yu Y, Xia Z, Zhang C
Cell death & disease 2023 Aug 21;14(8):539
Cell death & disease 2023 Aug 21;14(8):539
Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas.
Mischkulnig M, Roetzer-Pejrimovsky T, Lötsch-Gojo D, Kastner N, Bruckner K, Prihoda R, Lang A, Martinez-Moreno M, Furtner J, Berghoff A, Woehrer A, Berger W, Widhalm G, Kiesel B
Frontiers in medicine 2022;9:907442
Frontiers in medicine 2022;9:907442
Disruption of cellular iron homeostasis by IREB2 missense variants causes severe neurodevelopmental delay, dystonia and seizures.
Maio N, Saneto RP, Steet R, Sotero de Menezes MA, Skinner C, Rouault TA
Brain communications 2022;4(3):fcac102
Brain communications 2022;4(3):fcac102
NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins.
Santana-Codina N, Del Rey MQ, Kapner KS, Zhang H, Gikandi A, Malcolm C, Poupault C, Kuljanin M, John KM, Biancur DE, Chen B, Das NK, Lowder KE, Hennessey CJ, Huang W, Yang A, Shah YM, Nowak JA, Aguirre AJ, Mancias JD
Cancer discovery 2022 Sep 2;12(9):2180-2197
Cancer discovery 2022 Sep 2;12(9):2180-2197
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.
Zhang T, Sun L, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H
Nature cancer 2022 Jan;3(1):75-89
Nature cancer 2022 Jan;3(1):75-89
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K
Nature 2021 Nov;599(7883):136-140
Nature 2021 Nov;599(7883):136-140
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Acoba MG, Alpergin ESS, Renuse S, Fernández-Del-Río L, Lu YW, Khalimonchuk O, Clarke CF, Pandey A, Wolfgang MJ, Claypool SM
Cell reports 2021 Mar 16;34(11):108869
Cell reports 2021 Mar 16;34(11):108869
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells.
Schwartz AJ, Goyert JW, Solanki S, Kerk SA, Chen B, Castillo C, Hsu PP, Do BT, Singhal R, Dame MK, Lee HJ, Spence JR, Lakhal-Littleton S, Vander Heiden MG, Lyssiotis CA, Xue X, Shah YM
Nature metabolism 2021 Jul;3(7):969-982
Nature metabolism 2021 Jul;3(7):969-982
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K
Molecular cell 2020 Feb 6;77(3):645-655.e7
Molecular cell 2020 Feb 6;77(3):645-655.e7
Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.
Palmieri EM, Gonzalez-Cotto M, Baseler WA, Davies LC, Ghesquière B, Maio N, Rice CM, Rouault TA, Cassel T, Higashi RM, Lane AN, Fan TW, Wink DA, McVicar DW
Nature communications 2020 Feb 4;11(1):698
Nature communications 2020 Feb 4;11(1):698
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Jing J, Ding N, Wang D, Ge X, Ma J, Ma R, Huang X, Jueraitetibaike K, Liang K, Wang S, Cao S, Zhao AZ, Yao B
Cell death & disease 2020 Aug 14;11(8):626
Cell death & disease 2020 Aug 14;11(8):626
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Maio N, Kim KS, Holmes-Hampton G, Singh A, Rouault TA
Haematologica 2019 Sep;104(9):1756-1767
Haematologica 2019 Sep;104(9):1756-1767
Involvement of protoporphyrin IX accumulation in the pathogenesis of isoniazid/rifampicin-induced liver injury: the prevention of curcumin.
He L, Guo Y, Deng Y, Li C, Zuo C, Peng W
Xenobiotica; the fate of foreign compounds in biological systems 2017 Feb;47(2):154-163
Xenobiotica; the fate of foreign compounds in biological systems 2017 Feb;47(2):154-163
A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.
Maio N, Kim KS, Singh A, Rouault TA
Cell metabolism 2017 Apr 4;25(4):945-953.e6
Cell metabolism 2017 Apr 4;25(4):945-953.e6
Heme levels are increased in human failing hearts.
Khechaduri A, Bayeva M, Chang HC, Ardehali H
Journal of the American College of Cardiology 2013 May 7;61(18):1884-93
Journal of the American College of Cardiology 2013 May 7;61(18):1884-93
MicroRNA-210 decreases heme levels by targeting ferrochelatase in cardiomyocytes.
Qiao A, Khechaduri A, Kannan Mutharasan R, Wu R, Nagpal V, Ardehali H
Journal of the American Heart Association 2013 Apr 22;2(2):e000121
Journal of the American Heart Association 2013 Apr 22;2(2):e000121
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FECH antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FECH. This antibody recognizes human,mouse,rat antigen. The FECH antibody has been validated for the following applications: ELISA, WB analysis.