12-6238-42

antibody from Invitrogen Antibodies
Targeting: TNFRSF10C CD263, DcR1, LIT, TRAILR3, TRID
Provider product page for 12-6238-42

Antibody data

Product number
12-6238-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD263 (TRAIL-R3) Monoclonal Antibody (DJR3), PE, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The DJR3 monoclonal antibody reacts with human Decoy receptor 1 (DcR1), a glycophospholipid-anchored cell surface protein also known as TRAIL-R3, TRID, and LIT. DcR1 has an extracellular TRAIL binding domain and lacks the cytoplasmic death domain (DD) shared by several members of the TNF receptor superfamily. DcR1, along with DcR2, protects cells from TRAIL-mediated cytotoxicity. DcR1 binds to TRAIL and inhibits binding of TRAIL to DR4 or DR5. DcR1 is expressed broadly in many normal tissues at low level, but not in most tumors. Overexpression of DcR1 attenuates TRAIL-induced apoptosis. Applications Reported: The DJR3 antibody has been reported for use in flow cytometric analysis. Applications Tested: This DJR3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells and human DcR1-transfected cells. This can be used at 5 µL (1 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 µm post-manufacturing filtered.
Reactivity
Human
Host
Mouse
Conjugate
Yellow dye
Isotype
IgG
Antibody clone number
DJR3
Vial size
100 Tests
Concentration
5 µL/Test
Storage
4° C, store in dark, DO NOT FREEZE!
TNFRSF10C protein structure - 12-6238-42 shown in red.