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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Flow cytometry [1]
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- Product number
- FAB633P - Provider product page
- Provider
- R&D Systems
- Product name
- Human TRAILR4/TNFRSF10D PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human TRAIL R4/TNFRSF10D in ELISAs and Western blots. In sandwich immunoassays, less than 5% cross-reactivity with recombinant human (rh) TRAIL R1, rhTRAIL R2, TRAIL R3, rhTRAIL, rhTNF-alpha , and rhTNF-beta is observed.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
Q9UBN6- Isotype
- IgG
- Antibody clone number
- 104918
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells.
Targeting Apoptotic Activity Against Prostate Cancer Stem Cells.
TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis.
TRAIL-engineered bone marrow-derived mesenchymal stem cells: TRAIL expression and cytotoxic effects on C6 glioma cells.
Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma.
Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia.
TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-α-mediated antitumor reactivity.
Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients.
Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.
Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.
Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage.
Madsen SD, Russell KC, Tucker HA, Glowacki J, Bunnell BA, O'Connor KC
Stem cell research & therapy 2017 Sep 29;8(1):201
Stem cell research & therapy 2017 Sep 29;8(1):201
Targeting Apoptotic Activity Against Prostate Cancer Stem Cells.
Jaworska D, Szliszka E
International journal of molecular sciences 2017 Jul 29;18(8)
International journal of molecular sciences 2017 Jul 29;18(8)
TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis.
Singh HD, Otano I, Rombouts K, Singh KP, Peppa D, Gill US, Böttcher K, Kennedy PTF, Oben J, Pinzani M, Walczak H, Fusai G, Rosenberg WMC, Maini MK
Scientific reports 2017 Jul 17;7(1):5514
Scientific reports 2017 Jul 17;7(1):5514
TRAIL-engineered bone marrow-derived mesenchymal stem cells: TRAIL expression and cytotoxic effects on C6 glioma cells.
Tang XJ, Lu JT, Tu HJ, Huang KM, Fu R, Cao G, Huang M, Cheng LH, Dai LJ, Zhang L
Anticancer research 2014 Feb;34(2):729-34
Anticancer research 2014 Feb;34(2):729-34
Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma.
Kim SM, Woo JS, Jeong CH, Ryu CH, Jang JD, Jeun SS
Stem cells translational medicine 2014 Feb;3(2):172-82
Stem cells translational medicine 2014 Feb;3(2):172-82
Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia.
Gojo I, Tan M, Fang HB, Sadowska M, Lapidus R, Baer MR, Carrier F, Beumer JH, Anyang BN, Srivastava RK, Espinoza-Delgado I, Ross DD
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Apr 1;19(7):1838-51
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Apr 1;19(7):1838-51
TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-α-mediated antitumor reactivity.
Kalb ML, Glaser A, Stary G, Koszik F, Stingl G
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 15;188(4):1583-91
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 15;188(4):1583-91
Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients.
Stary G, Klein I, Kohlhofer S, Koszik F, Scherzer T, Müllauer L, Quendler H, Kohrgruber N, Stingl G
Blood 2009 Oct 29;114(18):3854-63
Blood 2009 Oct 29;114(18):3854-63
Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.
Secchiero P, Melloni E, Corallini F, Beltrami AP, Alviano F, Milani D, D'Aurizio F, di Iasio MG, Cesselli D, Bagnara GP, Zauli G
Stem cells (Dayton, Ohio) 2008 Nov;26(11):2955-63
Stem cells (Dayton, Ohio) 2008 Nov;26(11):2955-63
Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.
Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS
Cancer research 2008 Dec 1;68(23):9614-23
Cancer research 2008 Dec 1;68(23):9614-23
Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage.
Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, Das A, Lopes AR, Borrow P, Williams K, Humphreys E, Afford S, Adams DH, Bertoletti A, Maini MK
The Journal of experimental medicine 2007 Mar 19;204(3):667-80
The Journal of experimental medicine 2007 Mar 19;204(3):667-80
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of TRAIL R4/TNFRSF10D in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Mouse Anti-Human TRAIL R4/TNFRSF10D PE-conjugated Monoclonal Antibody (Catalog # FAB633P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
