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- References [9]
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- Product number
- 24063-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- DR4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DR4 antibody (Cat. #24063-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Combination of Compound Kushen Injection and cisplatin shows synergistic antitumor activity in p53-R273H/P309S mutant colorectal cancer cells through inducing apoptosis.
TRAIL produced by SAM-1-activated CD4+ and CD8+ subgroup T cells induces apoptosis in human tumor cells through upregulation of death receptors.
Luteolin enhances TRAIL sensitivity in non-small cell lung cancer cells through increasing DR5 expression and Drp1-mediated mitochondrial fission.
Fucoidan Induces Apoptosis of HT-29 Cells via the Activation of DR4 and Mitochondrial Pathway.
PDE3A inhibitor anagrelide activates death signaling pathway genes and synergizes with cell death-inducing cytokines to selectively inhibit cancer cell growth.
Jinfukang induces cellular apoptosis through activation of Fas and DR4 in A549 cells.
JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells.
Pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer.
Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study.
Wu X, Lu Y, Qin X
Journal of ethnopharmacology 2022 Jan 30;283:114690
Journal of ethnopharmacology 2022 Jan 30;283:114690
TRAIL produced by SAM-1-activated CD4+ and CD8+ subgroup T cells induces apoptosis in human tumor cells through upregulation of death receptors.
Zhang G, Xu M, Zhang X, Ma L, Zhang H
Toxicology and applied pharmacology 2021 Sep 15;427:115656
Toxicology and applied pharmacology 2021 Sep 15;427:115656
Luteolin enhances TRAIL sensitivity in non-small cell lung cancer cells through increasing DR5 expression and Drp1-mediated mitochondrial fission.
Wu B, Xiong J, Zhou Y, Wu Y, Song Y, Wang N, Chen L, Zhang J
Archives of biochemistry and biophysics 2020 Oct 15;692:108539
Archives of biochemistry and biophysics 2020 Oct 15;692:108539
Fucoidan Induces Apoptosis of HT-29 Cells via the Activation of DR4 and Mitochondrial Pathway.
Bai X, Wang Y, Hu B, Cao Q, Xing M, Song S, Ji A
Marine drugs 2020 Apr 20;18(4)
Marine drugs 2020 Apr 20;18(4)
PDE3A inhibitor anagrelide activates death signaling pathway genes and synergizes with cell death-inducing cytokines to selectively inhibit cancer cell growth.
An R, Liu J, He J, Wang F, Zhang Q, Yu Q
American journal of cancer research 2019;9(9):1905-1921
American journal of cancer research 2019;9(9):1905-1921
Jinfukang induces cellular apoptosis through activation of Fas and DR4 in A549 cells.
Lu J, Chen J, Kang Y, Wu J, Shi H, Fu Y, Jiao L, Dong C, Li X, Jin Y, Zhao W, Xu L, Zhao X
Oncology letters 2018 Oct;16(4):4343-4352
Oncology letters 2018 Oct;16(4):4343-4352
JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells.
Wang Q, Chen Q, Zhu L, Chen M, Xu W, Panday S, Wang Z, Li A, Røe OD, Chen R, Wang S, Zhang R, Zhou J
Oncogenesis 2017 Jul 3;6(7):e353
Oncogenesis 2017 Jul 3;6(7):e353
Pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer.
Yang J, Li G, Zhang K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1078-1087
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1078-1087
Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study.
Li HY, Zhang J, Sun LL, Li BH, Gao HL, Xie T, Zhang N, Ye ZM
Cell death & disease 2015 Jan 22;6:e1604
Cell death & disease 2015 Jan 22;6:e1604
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DR4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human DR4. This antibody recognizes human antigen. The DR4 antibody has been validated for the following applications: ELISA, WB analysis.
