10-1002

antibody from ABEOMICS Inc.
Targeting: TNFRSF10A Apo2, CD261, DR4, TRAILR-1, TRAILR1
Provider product page for 10-1002

Antibody data

Product number
10-1002 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-DR4 Antibody
Antibody type
Monoclonal
Description
Death receptor 4 (DR4) or TRAIL-R1, a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. DR4 expression is enhanced by DNA damage whether induced by ionizing radiation or by chemotherapeutic agents. On binding DR4, TRAIL induces cell death via caspase-dependent apoptosis. DR4 mediate oligomeric Abeta induction of extrinsic apoptotic pathways in human microvascular cerebral endothelial cells with activation of both caspase-8 and caspase-9. It is considered a promising molecular target for cancer therapy.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant human
DR4 protein (amino acids 2-203 was
used as an immunogen for this antib
ody.
Isotype
IgG
Antibody clone number
ABM1B11
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
TNFRSF10A protein structure - 10-1002 shown in red.