60006-1-Ig

antibody from Proteintech Group

Targeting: CD38

Provider product page for 60006-1-Ig

Western blot

ELISA

Immunocytochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [24]
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Product number: 60006-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#60006-1-Ig, RRID:AB_716994
Product name: CD38 antibody
Antibody type: Monoclonal
Description: KD/KO validated CD38 antibody (Cat. #60006-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, WB, ELISA.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 3C6G4
Vial size: 20ul, 150ul

CD38 protein structure - 60006-1-Ig shown in red.

Submitted references Germ-free piglets display variable neuroinflammatory-like perturbations in prefrontal cortical microglia.

Lester BA, Kelly C, Henry SN, Elias IP, Cevenini SE, Hendrickson MR, Park T, Ashley TD, Beltz JM, Milner JP, Pickrell AM, Morton PD
bioRxiv : the preprint server for biology 2026 Mar 24;

Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway.

Sun F, She R, Yang T, Chen B, Liao Z, Liao J, Mei Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157928

REV-ERBα regulates brain NAD(+) levels and tauopathy via an NFIL3-CD38 axis.

Lee J, Kang R, Park S, Saliu IO, Son M, Voorhees JR, Dimitry JM, Quillin EI, Woodie LN, Lananna BV, Gan L, Goo YA, Zhao G, Lazar MA, Burris TP, Musiek ES
Nature aging 2025 Oct;5(10):2070-2085

The Sirt3-CD38 axis induces mitochondrial dysfunction in hypertrophied heart by regulating mitochondrial calcium overload.

Liu J, Liu N, Qi C, Dong D, Liu B
European journal of medical research 2025 Oct 14;30(1):967

The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity.

Wu H, Liu J, Zhang XH, Jin S, Li P, Liu H, Zhao L, Wang J, Zhao S, Tian HD, Lai JR, Hao Y, Liu GR, Hou K, Yan M, Liu SL, Pang D
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 May;80:101222

CD38 Coordinates with NF-κB to Promote Cochlear Inflammation in Noise-Induced Hearing Loss: the Protective Effect of Apigenin.

Liu D, Sai N, Zhou Y, Yu N, Jiang QQ, Sun W, Han WJ, Guo W
Molecular neurobiology 2025 May;62(5):6166-6178

ZDHHC9-mediated CD38 palmitoylation stabilizes CD38 expression and promotes pancreatic cancer growth.

Guo H, Lin Z, Zhang D, Qin Q, Li Z, Yin Y, Chen J, Guo W
Communications biology 2025 Mar 22;8(1):477

Pelargonidin-3-O-galactoside Alleviates Acute Lung Injury Induced by Klebsiella pneumoniae by Targeting CD38-Mediated Pyroptosis.

Jiang F, Jiang J, Sun Y, Meng L, Chen J, Liang L, Wang X, Zhang H, Meng M, Yuan B, He S, Li R
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13415-13426

Single-cell transcriptomics identifies the common perturbations of monocyte/macrophage lineage cells in inflammaging of bone marrow.

Liao P, Tong S, Du L, Mei J, Wang B, Lu Y, Yao M, Zhang C, Liu D, Zhong Z, Ye F, Gao J
Journal of orthopaedic translation 2025 Jan;50:85-96

The effect of tocilizumab treatment for skin fibrosis by inhibiting CD38(+) macrophages in systemic sclerosis.

Chen H, Yang D, Shi Y, Wu H, Zhu H, Jiang T, Liu S, Wang D
Cellular immunology 2025 Feb;408:104914

Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.

Zhou J, Zhang L, Peng J, Zhang X, Zhang F, Wu Y, Huang A, Du F, Liao Y, He Y, Xie Y, Gu L, Kuang C, Ou W, Xie M, Tu T, Pang J, Zhang D, Guo K, Feng Y, Yin S, Cao Y, Li T, Jiang Y
Cell metabolism 2024 Sep 3;36(9):2054-2068.e14

CD38 modulates cytokine secretion by NK cells through the Sirt1/NF-κB pathway, suppressing immune surveillance in colorectal cancer.

Wang X, Song X, Fang K, Chang X
Scientific reports 2024 Nov 20;14(1):28702

NAD(+) supplementation improves mitochondrial functions and normalizes glaucomatous trabecular meshwork features.

Liu Y, Bu Q, Hu D, Chen C, Zhu J, Zhou Q, Li Z, Pan X
Experimental cell research 2024 Jul 1;440(1):114137

Control of NAD(+) homeostasis by autophagic flux modulates mitochondrial and cardiac function.

Zhang Q, Li Z, Li Q, Trammell SA, Schmidt MS, Pires KM, Cai J, Zhang Y, Kenny H, Boudina S, Brenner C, Abel ED
The EMBO journal 2024 Feb;43(3):362-390

Targeting CD38/ ADP-ribosyl cyclase as a novel therapeutic strategy for identification of three potent agonists for leukopenia treatment.

Liu Y, Zhang L, Wang L, Tang X, Wan S, Huang Q, Ran M, Shen H, Yang Y, Chiampanichayakul S, Tima S, Anuchapreeda S, Wu J
Pharmacological research 2024 Feb;200:107068

The use of a systems approach to increase NAD(+) in human participants.

Henderson JD, Quigley SNZ, Chachra SS, Conlon N, Ford D
npj aging 2024 Feb 1;10(1):7

NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.

Zhan R, Meng X, Tian D, Xu J, Cui H, Yang J, Xu Y, Shi M, Xue J, Yu W, Hu G, Li K, Ge X, Zhang Q, Zhao M, Du J, Guo X, Xu W, Gao Y, Yao C, Chen F, Chen Y, Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E, Wang Y, Zheng L
Neuron 2023 Nov 15;111(22):3634-3649.e7

Both prolonged high-fat diet consumption and calorie restriction boost hepatic NAD+ metabolism in mice.

Wei X, Wei C, Tan Y, Dong X, Yang Z, Yan J, Luo X
The Journal of nutritional biochemistry 2023 May;115:109296

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.

Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690

Longitudinal analyses reveal distinct immune response landscapes in lung and intestinal tissues from SARS-CoV-2-infected rhesus macaques.

Zheng H, Chen Y, Li J, Li H, Zhao X, Li J, Yang F, Li Y, Liu C, Qin L, Zuo Y, Zhang Q, He Z, Shi H, Li Q, Liu L
Cell reports 2022 May 24;39(8):110864

CD38-mediated Inhibition of Bruton's Tyrosine Kinase in Macrophages Prevents Endotoxemic Lung Injury.

Farahany J, Tsukasaki Y, Mukhopadhyay A, Mittal M, Nepal S, Tiruppathi C, Malik AB
American journal of respiratory cell and molecular biology 2022 Feb;66(2):183-195

Targeting Lymphotoxin Beta and Paired Box 5: a potential therapeutic strategy for soft tissue sarcoma metastasis.

Huang R, Zeng Z, Yan P, Yin H, Zhu X, Hu P, Zhuang J, Li J, Li S, Song D, Meng T, Huang Z
Cancer cell international 2021 Jan 4;21(1):3

Activation of astrocytic sigma-1 receptor exerts antidepressant-like effect via facilitating CD38-driven mitochondria transfer.

Wang Y, Ni J, Gao T, Gao C, Guo L, Yin X
Glia 2020 Nov;68(11):2415-2426

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1(+)CD38(hi) cells and anti-PD-1 resistance.

Verma V, Shrimali RK, Ahmad S, Dai W, Wang H, Lu S, Nandre R, Gaur P, Lopez J, Sade-Feldman M, Yizhak K, Bjorgaard SL, Flaherty KT, Wargo JA, Boland GM, Sullivan RJ, Getz G, Hammond SA, Tan M, Qi J, Wong P, Merghoub T, Wolchok J, Hacohen N, Janik JE, Mkrtichyan M, Gupta S, Khleif SN
Nature immunology 2019 Sep;20(9):1231-1243

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